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1.
J Org Chem ; 2021 Oct 06.
Artigo em Inglês | MEDLINE | ID: mdl-34612634

RESUMO

Daphnenoids A-C (1-3), three unusual sesquiterpenes with distinctive ring skeletons, together with a biogenetically related daphnenoid D (4) were obtained from the herb of Daphne penicillata by molecular networking strategies. Daphnenoid A (1) possesses a unique caged tetracyclo [5.3.2.01,6.04,11] dodecane scaffold by unexpected cyclizations of C-1/C-11 and C-2/C-14. Daphnenoids B and C (2 and 3) were the first discovered natural sesquiterpenes with unique 5/5 spirocyclic systems in nature. Their structures were determined by NMR spectroscopic analysis, computer-assisted structure elucidation methods, quantum chemical calculations, and X-ray diffraction. A hypothetical biogenetic pathway begins with typical guaiane sesquiterpene (a), including a key intermediate (4) was proposed. Daphnenoids B and C (2 and 3) exhibited potential inhibitory activities on the production of NO against LPS-induced BV2 microglial cells.

2.
Appl Opt ; 60(26): 8088-8096, 2021 Sep 10.
Artigo em Inglês | MEDLINE | ID: mdl-34613071

RESUMO

Electromagnetic (EM) metasurface mantles afford an alternative avenue, allowing for the possibility of rendering arbitrary-shape objects unobservable. But the available mechanisms either depend on the states of polarization or the azimuth of wave incidence, or cannot dynamically manipulate cloaking responses without altering the structures. Herein, a three-dimensional closed-ring-based metasurface carpet cloak involving Ge2Sb2Te5 that circumvents current drawbacks of metasurface structures is proposed. By judiciously designing meta-atoms on the external surface of a spherical object, the scattered wavefront, including the distributions of EM fields and polarizations, can be reconstructed, resembling what is deflected from a flat plane. Enabled by the perfectly symmetric distribution of meta-atoms, the carpet cloak is demonstrated to work well under arbitrary states of polarization and arbitrary azimuthal angles of incident light. Meanwhile, by converting Ge2Sb2Te5 from the amorphous to crystalline state, the designed scheme is empowered with the ability to switch "ON" and "OFF" of stealth states. Furthermore, the unique design achieves invisibility over ±20∘ angular span in the mid-infrared range from 8800 to 9450 nm. The validated recipe empowers robust steps forward to achieve full-polarization, full-azimuth operation, and switchable cloaking in the real-world, showing great potential applications in stealth, camouflage, and illusion fields.

4.
Zhongguo Ying Yong Sheng Li Xue Za Zhi ; 37(3): 300-304, 2021 May.
Artigo em Chinês | MEDLINE | ID: mdl-34374244

RESUMO

Objective: To investigate the effect of different arterial occlusion pressure and intermittent time on KAATSU-loaded deep-squat exercise on the characteristics of thigh muscle activation, find out the suitable relative value of personal blood pressure limit causing the maximum activation, and to provide some theoretical basis and practical reference for athletes to carry on the KAATSU Training scientifically. Methods: Ten elite male players were recruited, four kinds of external pressure condition with 0% arterial occlusion pressure (AOP), 40%AOP, 50%AOP, 60%AOP, respectively, were performed with 30%1RM(One repetition maximum)intensity of intermittent and continuous KAASTU-loaded deep-squat exercise. Wave plus wireless surface electromyography instrument was used to collect the surface EMG signals of the lower thigh muscle group. Root mean square (RMS) calculation was used to estimate muscle activity level. The normalized RMS values of the anterior thigh group and posterior thigh group were calculated by RMS of MVC, two-factor ANOVA analysis of variance were used to explore the effect of the activation of various muscle on external express and intermittent mode, to analyze the discrepancy during different external pressure. Results: ①A two-factor analysis of variance showed that different %AOP had significant effect on the normalized values of RMS of muscle measured by KAATSU deep-squat exercise(P<0.05), but intermittent mode had no significant effect on the standard value of RMS of muscle(P>0.05). The interaction of external pressure and intermittent mode on muscle RMS was not significant(P>0.05); ②The normalized RMS values of Rectus Femoris, Vastus Medialis, Vastus Lateralis, Biceps Femoris, Semitendinosus were significantly increased (P<0.05)in 50% AOP pressure condition during intermittent and continuous exercise; ③ The normalized RMS values of RF and VL were significantly increased(P<0.05)in 50% AOP pressure condition during intermittent and continuous exercise. The %MVC values of Vastus Medialis and Semitendinosus were significantly increased(P<0.05)in 60% AOP pressure condition during intermittent exercise. Conclusion: This study further verified that 50% AOP pressure can significantly improve the optimal activation quadriceps and posterior thigh groups and produce the best training effect for the high level handball players. It can not only promote the coordinated development of the agonist and antagonist, but also avoid overloading and prevent hamstring injury. At the same time, the intermittent mode is recommended to adopt the decompression intermittent mode.


Assuntos
Músculo Esquelético , Coxa da Perna , Eletromiografia , Exercício Físico , Humanos , Masculino , Músculo Quadríceps
5.
Nanomicro Lett ; 13(1): 109, 2021 Apr 13.
Artigo em Inglês | MEDLINE | ID: mdl-34138316

RESUMO

The current COVID-19 pandemic urges the extremely sensitive and prompt detection of SARS-CoV-2 virus. Here, we present a Human Angiotensin-converting-enzyme 2 (ACE2)-functionalized gold "virus traps" nanostructure as an extremely sensitive SERS biosensor, to selectively capture and rapidly detect S-protein expressed coronavirus, such as the current SARS-CoV-2 in the contaminated water, down to the single-virus level. Such a SERS sensor features extraordinary 106-fold virus enrichment originating from high-affinity of ACE2 with S protein as well as "virus-traps" composed of oblique gold nanoneedles, and 109-fold enhancement of Raman signals originating from multi-component SERS effects. Furthermore, the identification standard of virus signals is established by machine-learning and identification techniques, resulting in an especially low detection limit of 80 copies mL-1 for the simulated contaminated water by SARS-CoV-2 virus with complex circumstance as short as 5 min, which is of great significance for achieving real-time monitoring and early warning of coronavirus. Moreover, here-developed method can be used to establish the identification standard for future unknown coronavirus, and immediately enable extremely sensitive and rapid detection of novel virus.

6.
Zhongguo Zhong Yao Za Zhi ; 46(5): 1134-1140, 2021 Mar.
Artigo em Chinês | MEDLINE | ID: mdl-33787107

RESUMO

To establish the method for determining non-volatile ingredients of neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid, caffeic acid, isochlorogenic acid A, rosmarinic acid, ferulic acid, rutin, luteoloside, isoquercitrin, hesperidin, diosmin, diosmetin, luteolin, acacetin and linarin in Menthae Haplocalycis Herba formula granules and traditional herbal pieces by UPLC-MS/MS, and analyze the correlation of non-volatile ingredients in Menthae Haplocalycis Herba formula granules and traditional herbal pieces. Shim-pack GIST C_(18) column(2.1 mm×100 mm, 2 µm) was adopted with acetonitrile-0.1% formic acid aqueous solution as the mobile phase for gradient elution at the flow rate of 0.4 mL·min~(-1). The column temperature was set at 35 ℃. The quantitative analysis was performed using the electrospray ionization source and the multiple reaction monitoring. The linear relationship, resolution, repeatability and recovery of the 16 chemical components all met the requirements. The 16 non-volatile ingredients in traditional herbal pieces of Menthae Haplocalycis Herba could be tracked in formula granules. There were certain differences of the 16 chemical components among Menthae Haplocalycis Herba formula granules of different manufacturers and traditional herbal pieces of different producing areas. The UPLC-MS/MS method was simple, rapid and accurate, and could be used for the quality control of non-volatile ingredients in Menthae Haplocalycis Herba formula granules and traditional herbal pieces.


Assuntos
Medicamentos de Ervas Chinesas , Espectrometria de Massas em Tandem , Cromatografia Líquida de Alta Pressão , Cromatografia Líquida , Correlação de Dados
7.
ACS Appl Mater Interfaces ; 13(6): 7784-7791, 2021 Feb 17.
Artigo em Inglês | MEDLINE | ID: mdl-33533611

RESUMO

Recently, flexible neuromorphic devices have attracted extensive attention for the construction of perception cognitive systems with the ultimate objective to achieve robust computation, efficient learning, and adaptability to evolutionary changes. In particular, the design of flexible neuromorphic devices with data processing and arithmetic capabilities is highly desirable for wearable cognitive platforms. Here, an albumen-based protein-gated flexible indium tin oxide (ITO) ionotronic neuromorphic transistor was proposed. First, the transistor demonstrates excellent mechanical robustness against bending stress. Moreover, spike-duration-dependent synaptic plasticity and spike-amplitude-dependent synaptic plasticity behaviors are not affected by bending stress. With the unique protonic gating behaviors, neurotransmission processes in biological synapses are emulated, exhibiting three characteristics in neurotransmitter release, including quantal release, stochastic release, and excitatory or inhibitory release. In addition, three types of spike-timing-dependent plasticity learning rules are mimicked on the ITO ionotronic neuromorphic transistor. Most interestingly, algebraic arithmetic operations, including addition, subtraction, multiplication, and division, are implemented on the protein gated neuromorphic transistor for the first time. The present work would open a promising biorealistic avenue to the scientific community to control and design wearable "green" cognitive platforms, with potential applications including but not limited to intelligent humanoid robots and replacement neuroprosthetics.


Assuntos
Albuminas/química , Neurotransmissores/química , Óxidos/química , Compostos de Estanho/química , Plasticidade Neuronal , Tamanho da Partícula , Propriedades de Superfície , Transistores Eletrônicos
8.
Ann Agric Environ Med ; 27(3): 368-373, 2020 Sep 11.
Artigo em Inglês | MEDLINE | ID: mdl-32955216

RESUMO

INTRODUCTION: Chlorpyrifos (CPF) is a organophosphate insecticide widely used in agriculture with attendant adverse health outcomes. Chronic exposure to CPF induces oxidative stress and elicits harmful effects, including hepatic dysfunction. Molecular hydrogen has been identified as a novel antioxidant which could selectively scavenge hydroxyl radicals. OBJECTIVE: The aim of this study was to determine whether the intake of hydrogen-rich water (HRW) could protect rats from hepatotoxicity caused by sub-chronic exposure to CPF. MATERIAL AND METHODS: Rats were treated with hydrogen-rich water by oral intake for 8 weeks. Biochemical indicators of liver function, SOD and CAT activity, GSH and MDA levels were determined by the spectrophotometric method. Liver cell damage induced by CPF was evaluated by histopathological and electron microscopy analysis. PCR array analysis was performed to investigated the effects of molecular hydrogen on the regulation of oxidative stress related genes. RESULTS: Both the hepatic function tests and histopathological analysis showed that the liver damage induced by CPF could be ameliorated by HRW intake. HRW intake also attenuated CPF induced oxidative stress, as evidenced by restored SOD activities and MDA levels. The results of PCR Array identified 12 oxidative stress-related genes differentially expressed after CPF exposure, 8 of chich, including the mitochondrial Sod2 gene, were significantly attenuated by HRW intake. The electron microscopy results indicated that the mitochondrial damage caused by CPF was alleviated after HRW treatment. CONCLUSIONS: The results obtained suggest that HRW intake can protect rats from CPF induced hepatotoxicity, and the oxidative stress signaling and the mitochondrial pathway may be involved in the protection of molecular hydrogen.


Assuntos
Doença Hepática Induzida por Substâncias e Drogas/tratamento farmacológico , Clorpirifos/toxicidade , Hidrogênio/farmacologia , Inseticidas/toxicidade , Fígado/efeitos dos fármacos , Estresse Oxidativo/efeitos dos fármacos , Substâncias Protetoras/farmacologia , Animais , Doença Hepática Induzida por Substâncias e Drogas/etiologia , Relação Dose-Resposta a Droga , Masculino , Estresse Oxidativo/genética , Ratos , Ratos Wistar
9.
Opt Lett ; 45(18): 4964-4967, 2020 Sep 15.
Artigo em Inglês | MEDLINE | ID: mdl-32932428

RESUMO

We present a scheme to realize topological slow-light state with low group velocity and vanishing group velocity dispersion. By harnessing the strong interactions between two regular co-propagating topological photonic states in a magneto-optical photonic crystal waveguide, the energy flux transport of light exhibits a peculiar eight-shaped flowing loop within each unit cell of the waveguide. This permits the broadband pulse transporting with low group velocity (ng=13.26), broad bandwidth with a relative bandwidth of 3.08%, large normalized delay-bandwidth product (about 0.409), and vanishing group velocity dispersion. More importantly, they are robust against backscattering from obstacles. Our scheme paves the way to dig into the concept and physics of topology for solving the difficult problems of signal distortion and scattering loss in slow-light systems.

10.
Aging (Albany NY) ; 12(13): 13338-13353, 2020 07 08.
Artigo em Inglês | MEDLINE | ID: mdl-32644049

RESUMO

Circular RNAs (circRNAs) play an important role in cancer development and progression by regulating gene expression. The present study aimed to investigate the function of circRNA_100859 in colon cancer. circRNA expression profiles from a human circRNAs chip were analyzed. The effects of circRNA_100859 on cell proliferation and apoptosis were assessed in vitro and interactions between circRNA_100859 and its micro (mi)RNA and target genes were analyzed. The diagnostic and prognostic significance of circRNA_100859 was also investigated. It was identified that circRNA_100859 was overexpressed in colon cancer tissues and promoted cell proliferation and inhibited cell apoptosis. Additionally, bioinformatics and a dual-luciferase reporter assay confirmed that circRNA_100859 acted as a miR-217 sponge, and miR-217 directly targeted hypoxia-inducible factor (HIF)-1α. Rescue assays demonstrated that HIF-1α protein and mRNA expression levels and cell proliferation were regulated by the circRNA_100859/miR-217 axis (P<0.05). Furthermore, statistical analysis showed that the circRNA_100859-miR-217-HIF-1α axis was associated with Tumor-Node-Metastasis (TNM) stage, histological grade, and KRAS mutations, and also showed high diagnostic and prognostic value for patients with colon cancer (P<0.05). Therefore, it was concluded that circRNA_100859 functions as an oncogene in colon cancer by sponging the miR-217-HIF-1α pathway. In addition, the circRNA_100859-miR-217-HIF-1α axis may serve as a novel diagnostic and prognostic biomarker for patients with colon cancer.


Assuntos
Carcinogênese/genética , Neoplasias do Colo/genética , Subunidade alfa do Fator 1 Induzível por Hipóxia/genética , MicroRNAs/metabolismo , RNA Circular/metabolismo , Apoptose/genética , Biomarcadores Tumorais/genética , Biomarcadores Tumorais/metabolismo , Proliferação de Células/genética , Colectomia , Colo/patologia , Colo/cirurgia , Neoplasias do Colo/diagnóstico , Neoplasias do Colo/mortalidade , Neoplasias do Colo/cirurgia , Perfilação da Expressão Gênica , Regulação Neoplásica da Expressão Gênica , Células HCT116 , Humanos , Estimativa de Kaplan-Meier , Estadiamento de Neoplasias , Análise de Sequência com Séries de Oligonucleotídeos , Oncogenes , Prognóstico , Intervalo Livre de Progressão
11.
Theor Appl Genet ; 133(10): 2825-2837, 2020 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-32613264

RESUMO

KEY MESSAGE: Ogura CMS fertility-restored materials, with 18 chromosomes, normal seed setting, stable fertility and closer genetic background to the parent Chinese kale, were successfully developed in B. oleracea via a triploid strategy for the first time. Ogura cytoplasmic male sterility (CMS) is the most widely used sterile type in seed production for commercial hybrids of Brassica oleracea vegetables. However, the natural Ogura CMS restorer line has not been found in B. oleracea crops. In this study, the triploid strategy was used with the aim to create euploid B. oleracea progenies with the Rfo gene. The allotriploid AAC hybrid YL2 was used as a male parent to backcross with Ogura CMS Chinese kale. After successive backcrosses, the BC2 Rfo-positive individual 16CMSF2-11 and its BC3 progenies, with 18 chromosomes, were developed, which were morphologically identical to the parent Chinese kale. Compared with F1 and BC1 plants, it showed stable fertility performance, and regular meiosis behavior and could produce seeds normally under natural pollination. The genomic composition analysis of Rfo-positive progenies by using molecular markers showed that more than 87% of the C-genome components of BC3 Rfo-progenies recovered to the parent Chinese kale, while most or all of the An-genome segments were lost in 16CMSF2-11 and its progenies. The results suggested that the genetic background of Rfo-positive individuals was closer to that of the parent Chinese kale along with backcrossing. Hereof, the Ogura CMS fertility-restored materials of Chinese kale were successfully created via triploid strategy for the first time, providing a bridge for utilizing the Ogura CMS B. oleracea germplasm in the future. Moreover, our study indicates that the triploid strategy is effective for transferring genes from B. napus into B. oleracea.


Assuntos
Brassica napus/genética , Brassica/fisiologia , Fertilidade/genética , Triploidia , Cruzamentos Genéticos , Marcadores Genéticos , Mutação INDEL , Melhoramento Vegetal , Infertilidade das Plantas/genética
12.
Fish Physiol Biochem ; 46(5): 1743-1757, 2020 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-32514853

RESUMO

Gonadotropin-releasing hormone (GnRH) is a key neuropeptide of the reproductive system. However, little is known about the role of GnRH in the spotted scat (Scatophagus argus). Here, three GnRH subtypes (cGnRH-II, sGnRH, and sbGnRH) were identified in the spotted scat. cGnRH-II and sGnRH were only expressed in the brains and gonads of both male and female fish, exhibiting a tissue-specific expression pattern, while sbGnRH was expressed at different transcription levels in all examined tissues. During ovarian maturation, hypothalamus-associated sbGnRH was upregulated, while the expression of sGnRH was variable and cGnRH-II first increased and then decreased. In vivo experiments showed that sbGnRH significantly promoted the expression of fsh and lh genes in a dose-dependent manner and exhibited a desensitization effect on lh expression at high concentrations. For sGnRH and cGnRH-II, only high concentrations could induce fsh and lh expression. Furthermore, treatment with highly concentrated sbGnRH peptide also induced fsh and lh expression, whereas the sGnRH and cGnRH-II peptides only induced fsh expression in vitro. 17ß-Estradiol (E2) significantly inhibited the expression of sbGnRH mRNA in a dose-dependent manner and did not impact sGnRH and cGnRH-II mRNA levels in vivo or in vitro. The inhibitory effect of E2 on sbGnRH expression was attenuated by the estrogen receptor (ER) broad-spectrum antagonist (fulvestrant) and the ERα-specific antagonist (methyl-piperidinopyrazole), respectively, implying that the feedback regulation on sbGnRH is mediated via ERα. This study provides a theoretical basis for the reproductive endocrinology of the spotted scat by studying GnRH.


Assuntos
Estrogênios/metabolismo , Peixes/fisiologia , Hormônio Liberador de Gonadotropina/metabolismo , Sequência de Aminoácidos , Animais , Clonagem Molecular , DNA Complementar , Estradiol , Feminino , Hormônio Foliculoestimulante/metabolismo , Regulação da Expressão Gênica no Desenvolvimento/efeitos dos fármacos , Hormônio Liberador de Gonadotropina/genética , Hipotálamo , Hormônio Luteinizante/metabolismo , Ovário/crescimento & desenvolvimento , Filogenia , Receptores de Estrogênio/antagonistas & inibidores , Transcriptoma/efeitos dos fármacos
13.
Light Sci Appl ; 9: 75, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32377337

RESUMO

Advanced kirigami/origami provides an automated technique for modulating the mechanical, electrical, magnetic and optical properties of existing materials, with remarkable flexibility, diversity, functionality, generality, and reconfigurability. In this paper, we review the latest progress in kirigami/origami on the microscale/nanoscale as a new platform for advanced 3D microfabrication/nanofabrication. Various stimuli of kirigami/origami, including capillary forces, residual stress, mechanical stress, responsive forces, and focussed-ion-beam irradiation-induced stress, are introduced in the microscale/nanoscale region. These stimuli enable direct 2D-to-3D transformations through folding, bending, and twisting of microstructures/nanostructures, with which the occupied spatial volume can vary by several orders of magnitude compared to the 2D precursors. As an instant and direct method, ion-beam irradiation-based tree-type and close-loop nano-kirigami is highlighted in particular. The progress in microscale/nanoscale kirigami/origami for reshaping the emerging 2D materials, as well as the potential for biological, optical and reconfigurable applications, is briefly discussed. With the unprecedented physical characteristics and applicable functionalities generated by kirigami/origami, a wide range of applications in the fields of optics, physics, biology, chemistry and engineering can be envisioned.

14.
J Pain Res ; 12: 2999-3012, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31807057

RESUMO

Purpose: The purpose of this study was to explore the central analgesia mechanism of moxibustion for chronic inflammatory visceral pain (CIVP). Methods: A CIVP rat model was established by 2,4,6-trinitrobenzene sulfonic acid (TNBS) plus 50% ethanol via enema. The analgesic effect of moxibustion was evaluated using the abdominal withdrawal reflex (AWR), mechanical withdrawal threshold (MWT), and thermal withdrawal latency (TWL). The expression profile of phosphorylated proteins of the mitogen-activated protein kinase (MAPK) signaling pathway in the spinal cord was assayed by protein microarray. The differentially expressed proteins were examined by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) for functional clusters and corresponding signaling pathways. Results: Moxibustion exerted a significant analgesic effect for CIVP rats, mainly presenting as a decrease in the AWR score (all P<0.01) under different levels of distending pressure and an increase in MWT and TWL thresholds (all P<0.05). Compared with the normal group, 76 proteins were upregulated while 15 were downregulated, and MAPK signaling pathway was activated in the model group. Compared with the model group, there were 53 downregulated and 38 upregulated proteins in the moxibustion group, and MAPK signaling pathway was inhibited. Fold change (FC)>1.3 or <0.77 was taken as the screening standard to define the differentially expressed proteins. Fifteen differentially expressed proteins upregulated in the model group were downregulated in the moxibustion group. GO analysis showed that the differentially expressed proteins mainly controlled cellular metabolism regulation, transportation, and stress reactions. KEGG analysis revealed that these differentially expressed proteins were mostly involved in the ERK, JNK, and p38 pathways, and the ERK pathway was predominant. Conclusion: Moxibustion mitigates CIVP in rats and inhibits the phosphorylation of proteins in the spinal MAPK signaling pathway. The analgesic effect of moxibustion may be associated with the regulation of the spinal MAPK signaling pathway.

15.
J Geriatr Cardiol ; 16(10): 764-774, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31700516

RESUMO

Background: Qishen (QS) capsules, a Traditional Chinese Medicine, has been widely used to treat coronary heart disease in China. However, evidence of its effectiveness remains unclear. Methods: To explore whether QS has cardioprotective efficacy and/or promotes angiogenesis after myocardial infarction (MI), we performed experiments in a preclinical rat MI model. One month after left anterior descending coronary artery ligation, the rats received either QS solution (0.4 g/kg/day) or the same volume of saline by intragastric injection for four weeks. Results: Echocardiographic and hemodynamic analyses demonstrated relatively preserved cardiac function in MI rats administered QS. Indeed, QS treatment was associated with reduced infarct scar size and heart weight index, and these beneficial effects were responsible for enhancing angiogenesis. Mechanistically, QS treatment increased phosphorylation of protein kinase B (Akt) and downregulated phosphorylation of mitogen-activated protein kinase/extracellular-regulated kinase (MEK/ERK). Conclusions: QS therapy can improve the cardiac function of rats after MI by an underlying mechanism involving increased angiogenesis, at least partially via activation of the Akt signaling pathway and inhibition of MEK/ERK phosphorylation.

16.
Opt Express ; 27(17): 24738-24746, 2019 Aug 19.
Artigo em Inglês | MEDLINE | ID: mdl-31510358

RESUMO

We theoretically study the topological transition of dispersion types and propose a tunable planar lens based on graphene hyperbolic metamaterials (HMMs). By tuning the chemical potential (µc) of graphene, the dispersion relation of the HMM is topologically switchable between ellipse (µc<0.6 eV) and hyperbola (µc>0.6 eV) where positive and negative refractions occur respectively. Especially, for µc>0.6 eV, a Gaussian light beam is negatively refracted twice and focuses at a far-field point finally, acting well as a planar lens. Furthermore, its focal length l can be sensitively tuned by controlling µc, and Δl reaches 260 µm (from 528 to 268 µm) while µc varies with only 0.05 eV (from 0.65 to 0.7 eV). The physical reason is attributed to the different anisotropy degrees of EFCs for different µc. Such a compact, high-speed, and sensitively tunable planar lens holds great promise in photonic integration, photonic imaging, and directional coupling applications.

17.
Micromachines (Basel) ; 10(10)2019 Sep 21.
Artigo em Inglês | MEDLINE | ID: mdl-31546605

RESUMO

It is highly desirable to design optical devices with diverse optomechanical functions. Here, we investigate lateral optical force exerted on subwavelength-diameter (SD) optical fibers harnessed by input light modes with different polarizations. It is interesting to find that input light modes of circular or elliptical polarizations would bring about lateral optical force in new directions, which has not been observed in previous studies. By means of finite-difference time-domain (FDTD) simulations, detailed spatial distributions of the asymmetric transverse force density are revealed, meanwhile dependence of optical force on input light polarizations, fiber diameters, and inclination angles of fiber endfaces are all carefully discussed. It is believed that polarization-sensitive reflection, refraction, and diffraction of optical fields occur at the interface, i.e., fiber oblique endfaces, resulting in asymmetrically distributed optical fields and thereafter non-zero transverse optical force. We believe our new findings could be helpful for constructing future steerable optomechanical devices with more flexibility.

18.
Blood ; 133(16): 1720-1728, 2019 04 18.
Artigo em Inglês | MEDLINE | ID: mdl-30760451

RESUMO

Idiopathic multicentric Castleman disease (iMCD) is a rare lymphoproliferative disorder. The anti-interleukin 6 (IL-6) therapy siltuximab is not available everywhere, and is not effective for over one-half of patients. Alternative treatment approaches are urgently needed. In the first iMCD clinical trial directed against a target other than IL-6 signaling, we investigated a thalidomide-cyclophosphamide-prednisone (TCP) regimen in newly diagnosed iMCD patients. This single-center, single-arm, phase 2 study enrolled 25 newly diagnosed iMCD patients between June 2015 and June 2018. The TCP regimen (thalidomide 100 mg daily for 2 years; oral cyclophosphamide 300 mg/m2 weekly for 1 year; prednisone 1 mg/kg twice a week for 1 year) was administered for 2 years or until treatment failure. The primary end point was durable tumor and symptomatic response for at least 24 weeks. Twelve patients (48%) achieved the primary end point with no relapse, 3 patients (12%) demonstrated stable disease, and 10 patients (40%) were evaluated as treatment failure. Even when considering all patients, there were significant (P < .05) improvements in median symptom score, IL-6 level, hemoglobin, erythrocyte sedimentation rate, albumin, and immunoglobulin G. Among responders, the median levels of all evaluated parameters significantly improved, to the normal range, after treatment. The regimen was well tolerated. One patient died of pulmonary infection and 1 patient had a grade 3 adverse event (rash); 2 patients died following disease progression. Estimated 1-year progression-free survival and overall survival were 60% and 88%, respectively. The TCP regimen is an effective and safe treatment of newly diagnosed iMCD patients, particularly when siltuximab is unavailable. This trial was registered at www.clinicaltrials.gov as #NCT03043105.


Assuntos
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Hiperplasia do Linfonodo Gigante/tratamento farmacológico , Adulto , Idoso , Hiperplasia do Linfonodo Gigante/mortalidade , Ciclofosfamida/administração & dosagem , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Prednisona/administração & dosagem , Análise de Sobrevida , Talidomida/administração & dosagem , Resultado do Tratamento
19.
Int J Ophthalmol ; 12(1): 66-72, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30662842

RESUMO

AIM: To evaluate whether the level of thrombospondin-1 (TSP-1) in aqueous humor can predict the prognosis of trabeculectomy in patients with primary angle-closure glaucoma (PACG). METHODS: This case-control study involved 26 patients with PACG who experienced a failed trabeculectomy (case group) and 78 age- and sex-matched patients with PACG who underwent successful trabeculectomy (control group). Aqueous humor was collected at the time of trabeculectomy and tested for TSP-1 and TGF-ß2 levels with an enzyme-linked immunosorbent assay method. Logistic regression modeling was used to assess the risk factors for failed trabeculectomy. RESULTS: The mean TSP-1 aqueous concentrations were significantly higher in the case group (20.67±9.79 ng/mL) than the control group (5.17±2.29 ng/mL) (P<0.001). The transforming growth factor-ß2 (TGF-ß2) aqueous concentrations were significantly different between the case and control group, at 3633.25 and 1090.24 pg/mL, respectively (P<0.001). Logistic regression analysis revealed TSP-1 level as an independent risk factor for a failed trabeculectomy (OR=3.540; 95%CI=1.092-11.482). CONCLUSION: The aqueous humor TSP-1 and TGF-ß2 levels are higher in PACG eyes with failed trabeculectomy than with successful trabeculectomy at one year. The aqueous humor TSP-1 level is an independent risk factor associated with failed trabeculectomy.

20.
Nanoscale ; 10(35): 16630-16637, 2018 Sep 13.
Artigo em Inglês | MEDLINE | ID: mdl-30155531

RESUMO

Chiral metamaterials with versatile designs can exhibit orders of magnitude enhancement in chiroptical responses compared with that of the natural chiral media. Here, we propose an ease-of-fabrication three-dimensional (3D) chiral metamaterial consisting of vertical asymmetric plate-shape resonators along a planar air hole array with extraordinary optical transmission. It is theoretically shown that such chiral metamaterials simultaneously support five-fold plasmonic Fano resonance states and exhibit significant bisignate circular dichroism (CD) with amplitude as large as 0.8 due to the distinctive local electric field distributions. More interestingly, a "bridge" in the proposed double-plate-based architectures can act as a flipped ruler that is able to continuously manipulate optical chirality including the handedness-selective enhancement and the switching of CD signals. Importantly, the proposed designs have been readily fabricated by using a focused-ion-beam irradiation-induced folding technique and they consistently exhibited five-fold Fano resonances with strong CD effects in experiments. The studies are helpful for the understanding, designing and improvement of chiral optical systems towards potential applications such as ultrasensitive biosensing, polarimetric imaging, quantum information processing, etc.

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