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1.
Front Med (Lausanne) ; 8: 723167, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34646843

RESUMO

Previously, it was reported that multiple patients had hemolytic anemia associated with cimetidine administration, while only one patient who had received intravenous cimetidine was serologically diagnosed with drug-induced immune hemolytic anemia (DIIHA) caused by cimetidine-dependent antibodies. However, the ability of oral cimetidine intake to induce the production of antibodies has not been examined. In this study, we report a 44-year-old male patient in whom oral cimetidine administration resulted in cimetidine-dependent antibodies and drug-independent non-specific antibodies, leading to the development of DIIHA. Serological tests showed that the results of direct antiglobulin test (DAT) for anti-IgG (3+) and anti-C3d (1+) were positive. The IgM and IgG cimetidine-dependent antibodies (the highest total titer reached 4,096) were detected in the plasma incubated with O-type RBCs and 1 mg/mL cimetidine or the plasma incubated with cimetidine-coated RBCs. IgG-type drug-independent non-specific antibodies were detected in blood samples collected at days 13, 34, 41, and 82 post-drug intake. This is the first study to report that oral administration of cimetidine can elicit the production of cimetidine-dependent antibodies, leading to DIIHA, and the production of drug-independent non-specific antibodies, resulting in hemolytic anemia independent of cimetidine. Presence of pathogenic antibodies were detectable longer than 41 days. This suggests that patients with DIIHA caused by cimetidine need to be given necessary medical monitoring within 41 days after cimetidine intake.

2.
J Nanobiotechnology ; 19(1): 273, 2021 Sep 08.
Artigo em Inglês | MEDLINE | ID: mdl-34496881

RESUMO

The control of contagious or refractory diseases requires early, rapid diagnostic assays that are simple, fast, and easy-to-use. Here, easy-to-implement CRISPR/Cas12a-based diagnostic platform through Raman transducer generated by Raman enhancement effect, term as SERS-CRISPR (S-CRISPR), are described. The S-CRISPR uses high-activity noble metallic nanoscopic materials to increase the sensitivity in the detection of nucleic acids, without amplification. This amplification-free platform, which can be performed within 30-40 min of incubation time, is then used for detection of SARS-CoV-2 derived nucleic acids in RNA extracts obtained from nasopharyngeal swab specimens (n = 112). Compared with the quantitative reverse transcription polymerase chain reaction (RT-qPCR), the sensitivity and specificity of S-CRISPR reaches 87.50% and 100%, respectively. In general, the S-CRISPR can rapidly identify the RNA of SARS-CoV-2 RNA without amplification and is a potential strategy for nucleic acid point of care test (POCT).


Assuntos
Sistemas CRISPR-Cas/genética , Técnicas de Amplificação de Ácido Nucleico , SARS-CoV-2/genética , SARS-CoV-2/isolamento & purificação , Análise Espectral Raman , COVID-19/diagnóstico , COVID-19/virologia , Regulação Fúngica da Expressão Gênica , Genes Virais , Humanos , RNA Viral/análise , Sensibilidade e Especificidade
3.
Nanotechnology ; 32(50)2021 Oct 06.
Artigo em Inglês | MEDLINE | ID: mdl-34525468

RESUMO

Nanoscale mapping of electric polarizability in a heterogeneous dielectric material with surface irregularities is of scientific and technical significance, but remains challenging. Here, we present an approach based on intermodulation electrostatic force microscopy (EFM) in conjunction with finite element computation for precise and high-resolution mapping of polarizability in dielectric materials. Instead of using electrostatic force in conventional quantitative EFM approaches, the force gradient is acquired to achieve an unprecedented spatial resolution. In the meantime, the finite element model is applied to eliminate the interference from the heterogeneity and surface irregularity of the sample. This approach directly reveals the high polarization ability of the amorphous region in a ferroelectric, semi-crystalline polymer with significant surface roughness, i.e. poly (vinylidene fluoride-co-chlorotrifluoroethylene), in which the result is consistent with the predicted data in the latest research. This work presenting a quantitative approach to nanoscale mapping of electric polarizability with unprecedented spatial resolution may help to reveal the complex property-structure correlation in heterogeneous dielectric materials.

4.
Anal Chim Acta ; 1179: 338820, 2021 Sep 22.
Artigo em Inglês | MEDLINE | ID: mdl-34535251

RESUMO

The number of CD8+ T lymphocytes (CD8 cells) in peripheral blood can directly reflect the immune status of the body and is widely used for auxiliary diagnosis and prognostic evaluation of diseases. There is an urgent need to develop a simple CD8 cell-counting platform to meet clinical needs. Our group designed a paper-based cell-counting method based on a blocking competition strategy. In addition, we developed a time-resolved fluorescence-blocking competitive lateral flow immunoassay (TRF-BCLFIA) for point-of-care CD8 cell counting that functions by measuring europium nanoparticle (EuNP)-labeled CD8 antibody probes that are not captured by CD8 cells, and we indirectly calculated the concentration of CD8 cells in samples. Within 30 min, four operation steps can provide an accurate CD8 cell count for a 75-µL whole-blood sample, and this approach can be implemented on a handheld device. The TRF-BCLFIA reliably quantified CD8 cells in whole-blood samples, in which the assay exhibited a linear correlation (R2 = 0.989) readout for CD8 cell concentrations ranging from 137 to 821 cells/µL. To validate this approach, our newly developed CD8 cell-counting tool was used to assess 33 tumor patient blood samples. The results showed a high consistency with a flow cytometry-based absolute count. This analysis approach is a promising alternative for the costly standard flow cytometry-based tools for CD8 cell counting in tumor patients in community clinics, small hospitals, and low medical resource regions. This technology would deliver simple diagnostics to patients anywhere in the world, regardless of geography or socioeconomic status.


Assuntos
Európio , Nanopartículas Metálicas , Linfócitos T CD8-Positivos , Citometria de Fluxo , Fluorimunoensaio , Humanos
5.
Front Med (Lausanne) ; 8: 697192, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34485334

RESUMO

There has previously been a report of a patient developing haemolytic anaemia following exposure to cefoperazone. Another case has been reported involving the detection of cefoperazone-dependent antibodies in the absence of immune haemolytic anaemia. To date, no serological evidence has been reported to suggest that cefoperazone can lead to drug-induced immune haemolytic anaemia (DIIHA). This report aims to fill these gaps in knowledge by describing a case of DIIHA caused by cefoperazone-dependent antibodies. A 59-year-old man developed fatal haemolytic anaemia while receiving cefoperazone-tazobactam or cefoperazone-sulbactam for the treatment of a lung infection that occurred after craniocerebral surgery. This eventually led to renal function impairment. Prior to the discontinuation of cefoperazone treatment, the patient showed strong positive (4+) results for both anti-IgG and anti-C3d direct antiglobulin test (DAT), while cefoperazone-dependent IgM and IgG antibodies were detected. The patient's plasma and O-type RBCs were incubated with tazobactam or sulbactam solution at 37°C for 3 h, the results of DAT for anti-IgG and anti-C3d were both positive. Forty-three days after the discontinuation of cefoperazone, the results of DAT for anti-IgG and anti-C3d were negative. Meanwhile incubation of the patient's fresh serum and his own RBCs with cefoperazone at 37°C, gave rise to mild haemolysis, and the results of DAT for both anti-IgG and anti-C3d were positive. It is suggested that cefoperazone-dependent antibodies can activate complement, and the non-immunologic protein adsorption effect of tazobactam or sulbactam can enhance IgG and complement binding to RBCs. This may promote the formation of immunocomplexes and complement activation, thereby aggravating haemolysis.

6.
J Biol Res (Thessalon) ; 28(1): 15, 2021 Jul 16.
Artigo em Inglês | MEDLINE | ID: mdl-34271975

RESUMO

E proteins are transcriptional regulators that regulate many developmental processes in animals and lymphocytosis and leukemia in Homo sapiens. In particular, E2A, a member of the E protein family, plays a major role in the transcriptional regulatory network that promotes the differentiation and development of B and T lymphocytes. E2A-mediated transcriptional regulation usually requires the formation of E2A dimers, which then bind to coregulators. In this review, we summarize the mechanisms by which E2A participates in transcriptional regulation from a structural perspective. More specifically, the C-terminal helix-loop-helix (HLH) region of the basic HLH (bHLH) domain first dimerizes, and then the activation domains of E2A bind to different coactivators or corepressors in different cell contexts, resulting in histone acetylation or deacetylation, respectively. Then, the N-terminal basic region (b) of the bHLH domain binds to or dissociates from a specific DNA motif (E-box sequence). Last, trans-activation or trans-repression occurs. We also summarize the properties of these E2A domains and their interactions with the domains of other proteins. The feasibility of developing drugs based on these domains is discussed.

7.
Nanomicro Lett ; 13(1): 124, 2021 May 11.
Artigo em Inglês | MEDLINE | ID: mdl-34138351

RESUMO

HIGHLIGHTS: Shape memory self-soldering tape used as conductive interconnecting material. Perfect shape and conductivity memory performance and anti-fatigue performance. Reversible strong-to-weak adhesion switched by temperature. With practical interest in the future applications of next-generation electronic devices, it is imperative to develop new conductive interconnecting materials appropriate for modern electronic devices to replace traditional rigid solder tin and silver paste of high melting temperature or corrosive solvent requirements. Herein, we design highly stretchable shape memory self-soldering conductive (SMSC) tape with reversible adhesion switched by temperature, which is composed of silver particles encapsulated by shape memory polymer. SMSC tape has perfect shape and conductivity memory property and anti-fatigue ability even under the strain of 90%. It also exhibits an initial conductivity of 2772 S cm-1 and a maximum tensile strain of ~ 100%. The maximum conductivity could be increased to 5446 S cm-1 by decreasing the strain to 17%. Meanwhile, SMSC tape can easily realize a heating induced reversible strong-to-weak adhesion transition for self-soldering circuit. The combination of stable conductivity, excellent shape memory performance, and temperature-switching reversible adhesion enables SMSC tape to serve two functions of electrode and solder simultaneously. This provides a new way for conductive interconnecting materials to meet requirements of modern electronic devices in the future.

8.
Nat Commun ; 12(1): 1406, 2021 Mar 03.
Artigo em Inglês | MEDLINE | ID: mdl-33658489

RESUMO

Oxidative dispersion has been widely used in regeneration of sintered metal catalysts and fabrication of single atom catalysts, which is attributed to an oxidation-induced dispersion mechanism. However, the interplay of gas-metal-support interaction in the dispersion processes, especially the gas-metal interaction has not been well illustrated. Here, we show dynamic dispersion of silver nanostructures on silicon nitride surface under reducing/oxidizing conditions and during carbon monoxide oxidation reaction. Utilizing environmental scanning (transmission) electron microscopy and near-ambient pressure photoelectron spectroscopy/photoemission electron microscopy, we unravel a new adsorption-induced dispersion mechanism in such a typical oxidative dispersion process. The strong gas-metal interaction achieved by chemisorption of oxygen on nearly-metallic silver nanoclusters is the internal driving force for dispersion. In situ observations show that the dispersed nearly-metallic silver nanoclusters are oxidized upon cooling in oxygen atmosphere, which could mislead to the understanding of oxidation-induced dispersion. We further understand the oxidative dispersion mechanism from the view of dynamic equilibrium taking temperature and gas pressure into account, which should be applied to many other metals such as gold, copper, palladium, etc. and other reaction conditions.

9.
Nano Lett ; 21(2): 1047-1055, 2021 Jan 27.
Artigo em Inglês | MEDLINE | ID: mdl-33404256

RESUMO

Thermoelectric (TE) technology provides a new way to directly harvest and convert the heat continuously released from the human body. The greatest challenge for TE materials applied in wearable TE generators is compatible with the constantly changing morphology of the human body while offering a continuous and stable power output. Here, a stretchable carboxylic single-walled carbon nanotube (SWNT)-based TE fiber is prepared by an improved wet-spinning method. The stable Seebeck coefficient of the annealed carboxylic SWNT-based TE fiber is 44 µV/K even under the tensile strain of ∼30%. Experimental results show that the fiber can continue to generate constant TE potential when it is changed to various shapes. The new stretchable TE fiber has a larger Seebeck coefficient and more stretchability than existing TE fibers based on the Seebeck effect, opening a path to using the technology for a variety of practical applications.

10.
ACS Appl Mater Interfaces ; 12(47): 53425-53434, 2020 Nov 25.
Artigo em Inglês | MEDLINE | ID: mdl-33174412

RESUMO

Heterogeneous dielectric materials such as dielectric polymer nanocomposites have attracted extensive attention because of their exceptional insulating and dielectric performance, which originates from the unique space charge dynamics associated with the various interfacial regions. However, the space charge distribution and transport in polymer nanocomposites remain elusive due to the lack of analytical methods that can precisely probe the charge profile at the nanoscale resolution. Although a few studies have explored the possibility of using scanning probe techniques for characterizing the local charge distribution, the interference from induced electrical polarization of the material has been unfortunately ignored, leading to inaccurate results. In this contribution, we report an open-loop Kelvin probe force microscopy (KPFM) method with nanoscale resolution for the direct detection of the space charge profile in dielectric polymer nanocomposites. Unlike the conventional studies where a vertical direct current (DC) voltage is applied on the sample through the probe to evoke the charge injection and transport in dielectric polymer nanocomposites, the present method is established based on a delicate electrode configuration where a lateral electric field is allowed to be applied on the sample during the KPFM test. This special testing configuration enables real-time charge injection and transport without inducing the electrical polarization of material along the vertical direction, which gives rise to clean mapping of space charges and reveals the interfacial charge trapping in polymer nanocomposites. This work provides a robust and reliable method for studying the sophisticated charge transport properties associated with the various interfacial regions in heterogeneous dielectric materials.

11.
Nat Commun ; 11(1): 3919, 2020 Aug 06.
Artigo em Inglês | MEDLINE | ID: mdl-32764558

RESUMO

Dielectric polymers for electrostatic energy storage suffer from low energy density and poor efficiency at elevated temperatures, which constrains their use in the harsh-environment electronic devices, circuits, and systems. Although incorporating insulating, inorganic nanostructures into dielectric polymers promotes the temperature capability, scalable fabrication of high-quality nanocomposite films remains a formidable challenge. Here, we report an all-organic composite comprising dielectric polymers blended with high-electron-affinity molecular semiconductors that exhibits concurrent high energy density (3.0 J cm-3) and high discharge efficiency (90%) up to 200 °C, far outperforming the existing dielectric polymers and polymer nanocomposites. We demonstrate that molecular semiconductors immobilize free electrons via strong electrostatic attraction and impede electric charge injection and transport in dielectric polymers, which leads to the substantial performance improvements. The all-organic composites can be fabricated into large-area and high-quality films with uniform dielectric and capacitive performance, which is crucially important for their successful commercialization and practical application in high-temperature electronics and energy storage devices.

12.
Nano Lett ; 20(8): 6176-6184, 2020 08 12.
Artigo em Inglês | MEDLINE | ID: mdl-32662654

RESUMO

Skin-mountable physical sensors that can individually detect mechanical deformations with high strain sensitivity within a broad working strain range and temperature variations with accurate temperature resolution are a sought-after technology. Herein, a stretchable temperature and strain dual-parameter sensor that can precisely detect and distinguish strain from temperature stimuli without crosstalk is developed, based on a printable titanium carbide (MXene)-silver nanowire (AgNW)-PEDOT:PSS-tellurium nanowire (TeNW) nanocomposite. With this dual-parameter sensor, strain and temperature are effectively transduced into electrically isolated signals through the electrically conductive MXene-AgNW and thermoelectric PEDOT:PSS-TeNW components, respectively. In addition, the synergistic effect between the MXene nanosheets and PEDOT:PSS also greatly enhances the stretchability and sensitivity of the sensing devices. These properties enable the nanocomposite to decouple responses between temperature and strain stimuli with an accurate temperature resolution of 0.2 °C and a gauge factor of up to 1933.3 in a working strain range broader than 60%.


Assuntos
Nanocompostos , Nanofios , Condutividade Elétrica , Prata , Temperatura
13.
Biosens Bioelectron ; 155: 112101, 2020 May 01.
Artigo em Inglês | MEDLINE | ID: mdl-32090873

RESUMO

A novel time-resolved fluorescence blocking lateral flow immunoassay (TRF-BLFIA) was developed for on-site differential diagnosis of pseudorabies virus (PRV)-infected and vaccinated pigs using europium nanoparticles (EuNPs)-labeled virion antigens and high titer PRV gE monoclonal antibodies (PRV gE-mAb). Upon application of a positive serum sample, the specific epitopes of gE protein on the EuNPs-PRV probe were blocked, inhibiting binding to the PRV gE-mAb on the T line, resulting in low or negligible fluorescence signal, whereas when a negative sample was applied, EuNPs-PRV probes would be able to bind the antibody at the T line, leading to high fluorescence signal. Under optimized conditions, TRF-BLFIA provided excellent sensitivity and selectivity. When testing swine clinical samples (n = 356), there was 96.1% agreement between this method and a most widely used commercial gE-ELISA kit. Moreover, our method was rapid (15 min), cost-efficient and easy to operate with simple training, allowing for on-site detection. Thus, TRF-BLFIA could be a practical tool to differentially diagnose PRV-infected and vaccinated pigs.


Assuntos
Antígenos Virais , Európio , Imunofluorescência , Herpesvirus Suídeo 1/imunologia , Nanopartículas Metálicas , Pseudorraiva/diagnóstico , Doenças dos Suínos/diagnóstico , Animais , Anticorpos Antivirais/sangue , Anticorpos Antivirais/imunologia , Antígenos Virais/imunologia , Pseudorraiva/imunologia , Reprodutibilidade dos Testes , Sensibilidade e Especificidade , Suínos , Doenças dos Suínos/imunologia
14.
ACS Nano ; 14(1): 1176-1184, 2020 Jan 28.
Artigo em Inglês | MEDLINE | ID: mdl-31904938

RESUMO

Lithium-iodine (Li-I2) batteries are promising candidates for next-generation electrochemical energy storage systems due to their high energy density and the excellent kinetic rates of I2 cathodes. However, dissolution of iodine and iodide has hindered their widespread adoption for practical applications. Herein, a Ti3C2Tx MXene foam with a three-dimensional hierarchical porous architecture is proposed as a cathode-electrolyte interface layer in Li-I2 batteries, enabling high-rate and ultrastable cycling performance at a high iodine content and loading mass. Theoretical calculations and empirical characterizations indicate that Ti3C2Tx MXene sheets with high metallic conductivity not only provide strong chemical binding with iodine species to suppress the shuttle effect but also facilitate fast redox reactions during cell cycling. As a result, the Li-I2 battery using a cathode with 70 wt % I2 cycled stably for over 1000 cycles at a rate of 2 C, even at an ultrahigh loading mass of 5.2 mg cm-2. To the best of the authors' knowledge, this is the highest reported loading at such a high iodine content. This work suggests that using a Ti3C2Tx MXene interface layer can enable the design and application of high-energy Li-I2 batteries.

15.
Adv Mater ; 32(3): e1805864, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-30941808

RESUMO

The rapid progression of portable and wearable electronics has necessitated the development of high-performing, miniaturized energy-storage devices with flexible form factors and high energy and power delivery. Printed micro-supercapacitors (MSCs), with in-plane interdigital configurations, is touted as a promising choice to fulfill these requirements. New printing technologies can assemble MSCs with fiscal and environmental benefits, large form factors, and at high throughputs, qualities not afforded with conventional microfabrication technologies. Here, recent progress in the preparation of functional ink systems for wearable MSCs, encompassing electrode materials, conductor materials, and electrolytes, is presented. First, a comprehensive background of the fundamentals of printing technology is introduced, with discussions focusing on methods of improving ink functionality while simultaneously retaining good printability. Second, various printing techniques to ensure manufacturable scaling of wearable MSCs with high areal electrochemical performance and small footprint are explored. Within the scope of these two topics, various issues that hinder the full materialization of widespread adoption of printed MSC and next steps to overcome these issues are discussed. Further deep dives in scientific and technical challenges are also presented, including limited functionality of the inks, low printing resolution, overlay accuracy, and complex encapsulation.

16.
Adv Sci (Weinh) ; 6(18): 1900943, 2019 Sep 18.
Artigo em Inglês | MEDLINE | ID: mdl-31559133

RESUMO

Lithium (Li) metal anodes have garnered increasing interest in recent years as its high theoretical capacity and low electrochemical potential promises a myriad of opportunities for various applications. However, one critical issue to overcome is the inhomogeneous deposition of Li+ during the plating and stripping process. This inhomogeneous deposition could result in uncontrollable dendrite growth, further leading to poor coulombic efficiency, shorter lifecycles, and safety concerns due to internal short circuit and thermal runaways. To address these issues, a 3D porous core-shell fiber scaffold is presented, comprising of well-dispersed SiO2, TiO2, and carbon, as superlithiophilic host materials for lithium anodes. The amorphous SiO2 and TiO2 allow for controllable nucleation and deposition of metal Li inside the porous core-shell fiber even at ultrahigh current densities of 10 mA cm-2. In addition, the interconnected conductive fiber with high porosity enables good electrical conductivity with fast ion transport and excellent mechanical strength to withstand massive Li loading during repeated cycles of stripping and plating. As a result, excellent cycling performance and high rate capability are observed in both symmetric cells and full cells, highlighting the feasibility of the proposed Li anode composite.

17.
ACS Cent Sci ; 5(8): 1352-1359, 2019 Aug 28.
Artigo em Inglês | MEDLINE | ID: mdl-31482117

RESUMO

Traditional covalent organic frameworks (COFs) are prepared via polymerization based on small molecular monomers. However, the employment of polymers as building blocks to construct COFs has not been reported yet. Herein, we create a new concept of polymer covalent organic frameworks (polyCOFs) formed by linear polymers as structural building blocks, which inherit the merits from both COFs and linear polymers. PolyCOFs represent a new category of porous COF materials that demonstrate good crystallinity and high stability. More importantly, benefiting from the flexibility and processability of a linear polymer, polyCOFs can spontaneously form defect-free, flexible, and freestanding membranes that exhibit excellent mechanical properties and undergo reversible mechanical transformation upon exposure to various organic vapors. For the first time, we demonstrated that polyCOF membranes can be used as artificial muscles to perform various complicated motions (e.g., lifting objects, doing "sit-ups") triggered by vapors. This study bridges the gap between one-dimensional amorphous linear polymers and crystalline polymer frameworks and paves a new avenue to prepare stimuli-responsive actuators using porous COF materials.

18.
J Am Chem Soc ; 141(30): 12064-12070, 2019 07 31.
Artigo em Inglês | MEDLINE | ID: mdl-31287954

RESUMO

Fabrication of hybrid membranes composed of porous materials embedded in polymer matrices is a subject of topical interest. Herein, we introduce a new class of hybrid membranes: hyper-cross-linked metal-organic polyhedra (HCMOPs). These membranes are based upon soluble MOPs that can serve as high-connectivity nodes in hyper-cross-linked polymer networks. HCMOPs spontaneously form macro-scale, defect-free, freestanding membranes, and, thanks to the covalent cross-linking of MOPs, the resulting membranes possess multiple functionalities: strong water permeability; self-healing ability; antimicrobial activity; and better separation and mechanical performance than pristine polyimine membranes. This study introduces a new concept for the design and fabrication of multifunctional membranes and also broadens the applications of MOPs.


Assuntos
Antibacterianos/farmacologia , Antifúngicos/farmacologia , Iminas/farmacologia , Estruturas Metalorgânicas/farmacologia , Polímeros/farmacologia , Antibacterianos/química , Antifúngicos/química , Cryptococcus neoformans/efeitos dos fármacos , Relação Dose-Resposta a Droga , Escherichia coli/efeitos dos fármacos , Iminas/química , Estruturas Metalorgânicas/química , Testes de Sensibilidade Microbiana , Polímeros/química , Saccharomyces cerevisiae/efeitos dos fármacos , Staphylococcus aureus/efeitos dos fármacos
19.
ACS Appl Mater Interfaces ; 11(28): 25330-25337, 2019 Jul 17.
Artigo em Inglês | MEDLINE | ID: mdl-31268659

RESUMO

MXene, a new class of two-dimensional materials, offers a unique combination of metallic conductivity and hydrophilicity. This material has shown great promise in numerous applications including electromagnetic interference shielding, sensing, energy storage, and catalysis. In this paper, we report on the fabrication of transparent, conductive, and flexible MXene/silver nanowire (AgNW) hybrid films, resulting in the highest figure of merit (162.49) in the reported literature to date regarding an MXene-based transparent electrode. The hybrid films, prepared via a simple and scalable solution-processed method, exhibit good electrical conductivity, high transmittance, low roughness, work function matching, and robust mechanical performance. Following film fabrication, the hybrid electrodes were demonstrated to function as transparent electrodes in fullerene molecule PTB7-Th:PC71BM and nonfullerene molecule PBDB-T:ITIC organic photovoltaics (OPVs). In an effort to further improve the performance of flexible OPVs, a ternary structure of PBDB-T:ITIC:PC71BM was demonstrated, resulting in a power conversion efficiency (PCE) of 8.30%. Mechanical properties were also quantified, with the flexible ternary organic solar cells capable of retaining 84.6% of the original PCE after 1000 bending and unbending cycles to a 5 mm bending radius. These optoelectronic and mechanical performance metrics represent a breakthrough in the field of flexible optoelectronics.

20.
ACS Nano ; 13(7): 8124-8134, 2019 Jul 23.
Artigo em Inglês | MEDLINE | ID: mdl-31244046

RESUMO

Skin-mountable and transparent devices are highly desired for next-generation electronic applications but are susceptible to unexpected ruptures or undesired scratches, which can drastically reduce the device lifetime. Developing wearable and transparent materials with healable function that can recover their original functionality after mechanical damage under mild and noninvasive repairing operation is thus imperative. Herein, we demonstrate that the incorporation of ultrasmall quantities of plasmonic silver nanoparticle (AgNP)@MXene nanosheet hybrids to serve as photothermal fillers in waterborne elastic polyurethane enables high transparency as well as effective light-triggered healing capabilities for wearable composite coatings. The AgNP@MXene hybrid functions as a highly effective photon captor, energy transformer, and molecular heater due to the amalgamation of (1) ultrahigh photothermal conversion efficiency, high thermal conductivity, and structural properties of MXene, (2) the outstanding plasmonic effect of AgNPs, and (3) the synergistic effects from their hybrids. The resulting wearable composite coating with ultralow loading of plasmonic AgNP@MXene hybrids (0.08 wt % or 0.024 vol %) can produce a significant temperature increase of ∼111 ± 2.6 °C after the application of 600 mW cm-2 light irradiation for 5 min, while maintaining a high optical transmittance of ∼83% at a thickness of ∼60 µm. This local temperature increase can rapidly heal the mechanical damage to the composite coating, with a healing efficiency above 97%.

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