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Mol Plant ; 2021 Mar 24.
Artigo em Inglês | MEDLINE | ID: mdl-33771698


Switch defective/sucrose non-fermentable (SWI/SNF) chromatin remodeling complexes are multi-subunit machines that play vital roles in the regulation of chromatin structure and gene expression. However, the mechanisms by which SWI/SNF complexes recognize their target loci in plants are not fully understood. Here, we show that the Arabidopsis thaliana bromodomain-containing proteins BRD1, BRD2, and BRD13 are core subunits of SWI/SNF complexes and critical for SWI/SNF genomic targeting. These three BRDs interact directly with multiple SWI/SNF subunits, including the BRAHMA (BRM) catalytic subunit. Phenotypic and transcriptomic analyses of the brd1 brd2 brd13 triple mutant revealed that these BRDs act largely redundantly to control gene expression and developmental processes that are also regulated by BRM. Genome-wide occupancy profiling demonstrated that these three BRDs extensively colocalize with BRM on chromatin. Simultaneous loss of function of three BRD genes results in reduced BRM protein levels and decreased occupancy of BRM on chromatin across the genome. Furthermore, we demonstrated that the bromodomains of BRDs are essential for genomic targeting of the BRD subunits of SWI/SNF complexes to their target sites. Collectively, these results demonstrate that BRD1, BRD2, and BRD13 are core subunits of SWI/SNF complexes and reveal their biological roles in facilitating genomic targeting of BRM-containing SWI/SNF complexes in plants.

BMC Med ; 18(1): 371, 2020 Dec 03.
Artigo em Inglês | MEDLINE | ID: mdl-33267887


BACKGROUND: Little is known about the inter-relationship among fruit and vegetable intake, gut microbiota and metabolites, and type 2 diabetes (T2D) in human prospective cohort study. The aim of the present study was to investigate the prospective association of fruit and vegetable intake with human gut microbiota and to examine the relationship between fruit and vegetable-related gut microbiota and their related metabolites with type 2 diabetes (T2D) risk. METHODS: This study included 1879 middle-age elderly Chinese adults from Guangzhou Nutrition and Health Study (GNHS). Baseline dietary information was collected using a validated food frequency questionnaire (2008-2013). Fecal samples were collected at follow-up (2015-2019) and analyzed for 16S rRNA sequencing and targeted fecal metabolomics. Blood samples were collected and analyzed for glucose, insulin, and glycated hemoglobin. We used multivariable linear regression and logistic regression models to investigate the prospective associations of fruit and vegetable intake with gut microbiota and the association of the identified gut microbiota (fruit/vegetable-microbiota index) and their related fecal metabolites with T2D risk, respectively. Replications were performed in an independent cohort involving 6626 participants. RESULTS: In the GNHS, dietary fruit intake, but not vegetable, was prospectively associated with gut microbiota diversity and composition. The fruit-microbiota index (FMI, created from 31 identified microbial features) was positively associated with fruit intake (p < 0.001) and inversely associated with T2D risk (odds ratio (OR) 0.83, 95%CI 0.71-0.97). The FMI-fruit association (p = 0.003) and the FMI-T2D association (OR 0.90, 95%CI 0.84-0.97) were both successfully replicated in the independent cohort. The FMI-positive associated metabolite sebacic acid was inversely associated with T2D risk (OR 0.67, 95%CI 0.51-0.86). The FMI-negative associated metabolites cholic acid (OR 1.35, 95%CI 1.13-1.62), 3-dehydrocholic acid (OR 1.30, 95%CI 1.09-1.54), oleylcarnitine (OR 1.77, 95%CI 1.45-2.20), linoleylcarnitine (OR 1.66, 95%CI 1.37-2.05), palmitoylcarnitine (OR 1.62, 95%CI 1.33-2.02), and 2-hydroglutaric acid (OR 1.47, 95%CI 1.25-1.72) were positively associated with T2D risk. CONCLUSIONS: Higher fruit intake-associated gut microbiota and metabolic alteration were associated with a lower risk of T2D, supporting the public dietary recommendation of adopting high fruit intake for the T2D prevention.

Am J Health Behav ; 43(6): 1171-1185, 2019 11 01.
Artigo em Inglês | MEDLINE | ID: mdl-31662175


Objectives: This paper reports on the first study in China that used nationally representative data to compare mental health and depressive feeling between empty-nest and non-empty-nest elderly people (over 60 years old), and examine whether the health disparities (if any) can be explained by differences in family, emotional, housework, and economic support. Methods: We used the 2010 China General Social Survey and multivariate regression models to examine mental health and depressive feeling of 556 non-empty-nest and 210 empty-nest elderly people in China. Results: After controlling for various socio-demographic characteristics, although the empty-nest elderly were significantly more likely to report depressive feeling and poor mental health than non-empty-nest elderly, the difference was only statistically significant for depressive feeling. Importantly, the disparity in both depressive feeling and mental health can be mediated by differences in family economic support and household economic pressure. Conclusions: Our results highlight the risks of depressive feeling arising from the empty-nest living arrangement of elderly people and suggest that a poorer economic situation may result from decreased mental health. Drawing upon these results, future public policies aimed at improving mental health of empty-nest elderly may need to be more targeted to improve their economic conditions such as ameliorating pension and social welfare system shortcomings.

Depressão/etiologia , Depressão/psicologia , Solidão , Saúde Mental , Características de Residência , Idoso , China/epidemiologia , Estudos Transversais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Medição de Risco , Inquéritos e Questionários
Clin Nutr ESPEN ; 33: 171-177, 2019 10.
Artigo em Inglês | MEDLINE | ID: mdl-31451256


BACKGROUND & AIMS: The association between dietary acid load and hypertension risk is inconclusive. We conducted a systematic review and meta-analysis to summarize effect of dietary acid load on blood pressure. METHODS: A comprehensively search was performed in electronic databases including EMBASE, PubMed, Web of Science and Chinese National Knowledge Infrastructure. Summary ORs and their corresponding 95% CIs were computed assuming a randomized model or fixed model. RESULTS: Ten publications comprising 4 cohort and 6 cross-sectional studies were eligible for meta-analysis. There were 8 studies about potential renal acid load (PRAL) and 4 about net endogenous acid production (NEAP). Essential hypertension was statistically associated with higher PRAL (OR = 1.14, 95% CI = 1.02-1.17). Our findings also demonstrated a positive impact of higher PRAL on elevating both diastolic pressure (WMD = 0.96, 95% CI = 0.67-1.26) and systolic pressure (WMD = 1.57, 95% CI = 1.12-2.03). A 35% increased risk of hypertension associated with higher NEAP was identified (OR = 1.35, 95% CI = 1.03-1.78). CONCLUSIONS: The current study suggests that dietary acid load might be potential risk factor of hypertension.

Ácidos/administração & dosagem , Dieta/efeitos adversos , Hipertensão/etiologia , Pressão Sanguínea , Bases de Dados Factuais , Humanos , Rim , Avaliação Nutricional , Fatores de Risco
Am J Health Behav ; 43(4): 866-876, 2019 07 01.
Artigo em Inglês | MEDLINE | ID: mdl-31239027


Objectives: Large-scale influxes of international immigrants into England have stimulated heated debate about whether the increasing ethnic diversity has undermined local residents' life satisfaction and wellbeing. In this paper, we provide the first nationally representative evidence on the relationship between international immigration and local residents' life satisfaction in England. Methods: We used multilevel linear regression models to analyze nationally representative data (2011-2012) from 23,143 respondents and neighborhood level data from the 2011 Census. Results: The results show that the local share of international immigrants who arrived in 2010-2011, in particular the non-white immigrants, has a significantly adverse impact on local people's life satisfaction. Further analysis shows that the adverse impact of migration is particularly pronounced for local residents who do not have a job or from intermediate social class. Conclusions: This study enables a better understanding of the link between international immigration and life satisfaction, highlighting the need of public policies to be more targeted to areas that experienced great influxes of international immigrants by facilitating positive interactions and communication between international immigrants and the local residents.

Diversidade Cultural , Emigrantes e Imigrantes/estatística & dados numéricos , Emigração e Imigração/estatística & dados numéricos , Emprego/estatística & dados numéricos , Satisfação Pessoal , Classe Social , Adulto , Censos , Inglaterra , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Análise Multinível
J Phys Condens Matter ; 29(14): 145801, 2017 Apr 12.
Artigo em Inglês | MEDLINE | ID: mdl-28248641


Using magnetization, dielectric constant, and neutron diffraction measurements on a high quality single crystal of YBaCuFeO5 (YBCFO), we demonstrate that the crystal shows two antiferromagnetic transitions at [Formula: see text] K and [Formula: see text] K, and displays a giant dielectric constant with a characteristic of the dielectric relaxation at T N2. It does not show the evidence of the electric polarization for the crystal used for this study. The transition at T N1 corresponds with a paramagnetic to antiferromagnetic transition with a magnetic propagation vector doubling the unit cell along three crystallographic axes. Upon cooling, at T N2, the commensurate spin ordering transforms to a spiral magnetic structure with a propagation vector of ([Formula: see text] [Formula: see text] [Formula: see text]), where [Formula: see text], [Formula: see text], and [Formula: see text] are odd, and the incommensurability δ is temperature dependent. Around the transition boundary at T N2, both commensurate and incommensurate spin ordering coexist.