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1.
Quant Imaging Med Surg ; 9(2): 230-237, 2019 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-30976547

RESUMO

Background: Grey matter volume (GMV) loss has been observed in patients with non-alcoholic cirrhosis, but the underlying mechanisms are unknown. Oxidative stress (OS) is a recognized feature and systemic phenomenon of cirrhosis. However, little is known about whether OS is associated with GMV loss in cirrhosis. This study aimed to assess the relationship between oxidative damage and GMV loss in patients with non-alcoholic cirrhosis. Methods: Thirty-four patients with non-alcoholic cirrhosis and 27 age- and sex-matched healthy controls were enrolled in this prospective study. All subjects underwent brain magnetic resonance imaging (MRI), and voxel-based morphometry (VBM) was performed to assess normalized global GMV. As an OS marker, serum malondialdehyde (MDA) levels were determined in all subjects. In the patient group, a correlation analysis was used to investigate the relationship between serum MDA levels and normalized global GMV. Results: Compared with healthy controls, cirrhotic patients displayed a significant decrease in normalized global GMV and a significant increase in serum MDA levels. In the patient group, serum MDA levels were negatively correlated with normalized global GMV adjusted for age, sex and Child-Pugh class. Conclusions: Increased serum MDA levels were associated with GMV loss in patients with non-alcoholic cirrhosis, suggesting that oxidative damage may be involved in GMV loss observed in cirrhotic patients.

2.
Huan Jing Ke Xue ; 39(9): 4096-4104, 2018 Sep 08.
Artigo em Chinês | MEDLINE | ID: mdl-30188050

RESUMO

Different combinations of low impact development (LID) technologies can be applied for control of urban non-point source pollution. There are currently few evaluations of urban non-point source pollution and pollution load reduction based on a combination of porous asphalt and bio-retention. Taking Shenzhen International Low Carbon City as an example, road-deposited sediments were collected prior to and after rainfall events. Runoff was monitored under six typical rainfall events, from porous asphalt and the inlet/outlet of bio-retention. Through analysis of changes in the process of "build-up-wash-off-transport" of pollutant loads, the average build-up of road-deposited sediments in the study area was found to be (15.80±3.79) g·m-2; the mass percentage of road-deposited sediments (size>250 µm) was approximately 65.14%. The average wash-off percentage of six different intensity rainfall events was 17.15%, and road-deposited sediments (size<105 µm) were carried by 62.71%-74.94%. The average pollution loads of surface runoff pollutants SS, TN, and TP were 2.02, 0.025, and 0.0013 g·m-2, respectively. The removal rates of SS, TN, and TP through porous asphalt under infiltration and filtration were 70.26%, 46.29%, and 19.27%, respectively. The secondary purification removal rates of runoff water in bio-retention were 85.25%, 20.22%, and 70.27%, respectively. Pollutant loads into Dingshan River totaled 0.08, 0.011, and 0.0003 g·m-2, representing 4.05%, 43.47%, and 24.39% of runoff. The combination thus had a significant effect on runoff purification. Through quantitative research on the formation of non-point source pollution, this paper provides a scientific basis for estimating pollution loads of urban non-point source pollution and evaluating the performance of LID projects. It makes suggestions for the popularization and application of LID and sponge city design in China.

3.
Discov Med ; 23(124): 27-39, 2017 01.
Artigo em Inglês | MEDLINE | ID: mdl-28245425

RESUMO

A superparamagnetic iron oxide (SPIO) nanoshell and polyvinyl alcohol (PVA) based chemoembolization system for anti-cancer drug doxorubicin (DOX) delivery has previously been presented. We have also previously confirmed the feasibility and safety of this multifunctional system for carrying both DOX and SPIO nanoparticles in vitro. However, the pharmacokinetic and the therapeutic efficacy of this novel drug-delivery system in vivo is not yet clear, and as such was the subject of this study. A rabbit liver tumor model was utilized, whereby the tumors were targeted by SPIO/DOX/PVA composite infused via a catheter into the hepatic arteries which supplying blood to the tumor. The result was compared to saline, DOX+PVA, or SPIO/DOX infusion alone. SPIO/DOX/PVA displayed sustained chemotherapeutic agent release into the tumor. In comparison to other treatment groups, tumor growth rate was significantly slowed down by SPIO/DOX/PVA with a smaller tumor volume and a prolonged survival time of the experimental rabbits. Liver function results demonstrated SPIO/DOX/PVA has no apparent toxicity to the normal liver. Pharmacokinetic studies and histological evaluations in SPIO/DOX/PVA group revealed that long-term retention and drug release within the tumor associated with SPIO/DOX/PVA therapy, and thereafter induced significantly enhanced tumor necrosis and apoptosis. We conclude SPIO/DOX/PVA provides a highly effective therapeutic strategy for management of liver tumors.


Assuntos
Compostos Férricos/química , Neoplasias Hepáticas/tratamento farmacológico , Nanoconchas/química , Álcool de Polivinil/química , Animais , Antineoplásicos/química , Antineoplásicos/uso terapêutico , Quimioembolização Terapêutica , Doxorrubicina/química , Doxorrubicina/uso terapêutico , Portadores de Fármacos/química , Imagem por Ressonância Magnética , Nanopartículas de Magnetita/química , Masculino , Coelhos
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