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1.
Rev Soc Bras Med Trop ; 49(2): 150-7, 2016 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-27192582

RESUMO

Approximately 90% of the world population is infected by Epstein-Barr virus (EBV). Usually, it infects B lymphocytes, predisposing them to malignant transformation. Infection of epithelial cells occurs rarely, and it is estimated that about to 10% of gastric cancer patients harbor EBV in their malignant cells. Given that gastric cancer is the third leading cause of cancer-related mortality worldwide, with a global annual incidence of over 950,000 cases, EBV-positive gastric cancer is the largest group of EBV-associated malignancies. Based on gene expression profile studies, gastric cancer was recently categorized into four subtypes; EBV-positive, microsatellite unstable, genomically stable and chromosomal instability. Together with previous studies, this report provided a more detailed molecular characterization of gastric cancer, demonstrating that EBV-positive gastric cancer is a distinct molecular subtype of the disease, with unique genetic and epigenetic abnormalities, reflected in a specific phenotype. The recognition of characteristic molecular alterations in gastric cancer allows the identification of molecular pathways involved in cell proliferation and survival, with the potential to identify therapeutic targets. These findings highlight the enormous heterogeneity of gastric cancer, and the complex interplay between genetic and epigenetic alterations in the disease, and provide a roadmap to implementation of genome-guided personalized therapy in gastric cancer. The present review discusses the initial studies describing EBV-positive gastric cancer as a distinct clinical entity, presents recently described genetic and epigenetic alterations, and considers potential therapeutic insights derived from the recognition of this new molecular subtype of gastric adenocarcinoma.


Assuntos
Adenocarcinoma/virologia , Infecções por Vírus Epstein-Barr/genética , Neoplasias Gástricas/virologia , Adenocarcinoma/genética , Epigênese Genética , Infecções por Vírus Epstein-Barr/complicações , Regulação Neoplásica da Expressão Gênica , Humanos , Neoplasias Gástricas/genética
2.
Rev. Soc. Bras. Med. Trop ; 49(2): 150-157, Mar.-Apr. 2016. tab, graf
Artigo em Inglês | LILACS-Express | ID: lil-782099

RESUMO

Abstract: Approximately 90% of the world population is infected by Epstein-Barr virus (EBV). Usually, it infects B lymphocytes, predisposing them to malignant transformation. Infection of epithelial cells occurs rarely, and it is estimated that about to 10% of gastric cancer patients harbor EBV in their malignant cells. Given that gastric cancer is the third leading cause of cancer-related mortality worldwide, with a global annual incidence of over 950,000 cases, EBV-positive gastric cancer is the largest group of EBV-associated malignancies. Based on gene expression profile studies, gastric cancer was recently categorized into four subtypes; EBV-positive, microsatellite unstable, genomically stable and chromosomal instability. Together with previous studies, this report provided a more detailed molecular characterization of gastric cancer, demonstrating that EBV-positive gastric cancer is a distinct molecular subtype of the disease, with unique genetic and epigenetic abnormalities, reflected in a specific phenotype. The recognition of characteristic molecular alterations in gastric cancer allows the identification of molecular pathways involved in cell proliferation and survival, with the potential to identify therapeutic targets. These findings highlight the enormous heterogeneity of gastric cancer, and the complex interplay between genetic and epigenetic alterations in the disease, and provide a roadmap to implementation of genome-guided personalized therapy in gastric cancer. The present review discusses the initial studies describing EBV-positive gastric cancer as a distinct clinical entity, presents recently described genetic and epigenetic alterations, and considers potential therapeutic insights derived from the recognition of this new molecular subtype of gastric adenocarcinoma.

4.
Rev. méd. Minas Gerais ; 3(3): 163-5, jul.-set. 1993. ilus
Artigo em Português | LILACS | ID: lil-129423

RESUMO

O adenocarcinoma de células claras de vagina é uma entidade rara, embora sua incidência tenha se elevado em decorrência da exposiçäo intra-uterina das pacientes ao hormônio Dietilestilbestrol. Na maioria dos casos relatados na literatura, o diagnóstico foi feito precocemente, o que concorreu para o bom prognóstico das pacientes. A recidiva, na maioria das vezes, ocorreu locorregionalmente. Näo há relato de acometimento de medula óssea pelo tumor. No presente trabalho, relatamos o caso de uma paciente de 52 anos que apresentou uma recorrência fulminante de um adenocarcinoma de células claras de vagina tratado satisfatoriamente com cirurgia e radioterapia, com acometimento maciço de medula ossea e pancitopenia, o que levou ao óbito por sangramento do SNC. A correlaçäo do aparecimento do tumor com a exposiçäo materna ao Dietilestilbestrol näo pode ser feita.


Assuntos
Humanos , Feminino , Pessoa de Meia-Idade , Adenocarcinoma/cirurgia , Neoplasias da Medula Espinal , Neoplasias Vaginais/cirurgia , Adenocarcinoma/complicações , Adenocarcinoma/radioterapia , Dietilestilbestrol/efeitos adversos , Pancitopenia , Recidiva , Neoplasias Vaginais/complicações , Neoplasias Vaginais/radioterapia
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