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1.
J Minim Access Surg ; 2020 Oct 11.
Artigo em Inglês | MEDLINE | ID: mdl-33047687

RESUMO

Background: The enhanced recovery after surgery (ERAS) programme is feasible and effective in reducing the length of hospital stay, overall complication rates and medical costs when applied to cases involving colonic and rectal resections. However, a recent prospective, randomised, open, parallel-controlled trial (Chinese Laparoscopic Gastrointestinal Surgery Study-01 trial), initiated by our team, indicated that under conventional peri-operative management, the reduction of the post-operative hospital stay of laparoscopic distal gastrectomy (LDG) is quite limited compared with open gastrectomy. Thus, if we could provide valuable clinical evidence for demonstrating the efficacy of the ERAS programme for gastric cancer patients undergoing LDG, it would significantly enhance the peri-operative management of gastrectomy and benefit the patients. Methods: In this prospective single-arm trial, patients who are 18-75 years of age with gastric adenocarcinoma diagnosed with cT1-4aN0-3M0 and expected to undergo curative resection through LDG, are considered eligible for this study. All participants underwent LDG with peri-operative management under the ERAS programme. The primary outcome measures included the post-operative hospital stays and rehabilitative rate of the post-operative day 4. The secondary outcome measures are morbidity and mortality (time frame: 30 days), post-operative recovery index (time frame: 30 days), post-operative pain intensity (time frame: 3 days) and the medical costs from surgery to discharge. Conclusion: With reasonable and scientific designing, the trial may be a great help to further discuss the benefit of ERAS programme and thus improving the peri-operative management of patients with gastrectomy.

2.
JAMA Psychiatry ; 2020 Oct 14.
Artigo em Inglês | MEDLINE | ID: mdl-33052393

RESUMO

Importance: Polygenic risk scores (PRS) are predictors of the genetic susceptibility to diseases, calculated for individuals as weighted counts of thousands of risk variants in which the risk variants and their weights have been identified in genome-wide association studies. Polygenic risk scores show promise in aiding clinical decision-making in many areas of medical practice. This review evaluates the potential use of PRS in psychiatry. Observations: On their own, PRS will never be able to establish or definitively predict a diagnosis of common complex conditions (eg, mental health disorders), because genetic factors only contribute part of the risk and PRS will only ever capture part of the genetic contribution. Combining PRS with other risk factors has potential to improve outcome prediction and aid clinical decision-making (eg, determining follow-up options for individuals seeking help who are at clinical risk of future illness). Prognostication of adverse physical health outcomes or response to treatment in clinical populations are of great interest for psychiatric practice, but data from larger samples are needed to develop and evaluate PRS. Conclusions and Relevance: Polygenic risk scores will contribute to risk assessment in clinical psychiatry as it evolves to combine information from molecular, clinical, and lifestyle metrics. The genome-wide genotype data needed to calculate PRS are inexpensive to generate and could become available to psychiatrists as a by-product of practices in other medical specialties. The utility of PRS in clinical psychiatry, as well as ethical issues associated with their use, should be evaluated in the context of realistic expectations of what PRS can and cannot deliver. Clinical psychiatry has lagged behind other fields of health care in its use of new technologies and routine clinical data for research. Now is the time to catch up.

3.
Behav Res Methods ; 2020 Oct 19.
Artigo em Inglês | MEDLINE | ID: mdl-33078362

RESUMO

Phishing emails constitute a major problem, linked to fraud and exploitation as well as subsequent negative health outcomes including depression and suicide. Because of their sheer volume, and because phishing emails are designed to deceive, purely technological solutions can only go so far, leaving human judgment as the last line of defense. However, because it is difficult to phish people in the lab, little is known about the cognitive and neural mechanisms underlying phishing susceptibility. There is therefore a critical need to develop an ecologically valid lab-based measure of phishing susceptibility that will allow evaluation of the cognitive mechanisms involved in phishing detection. Here we present such a measure based on a task, the Phishing Email Suspicion Test (PEST), and a cognitive model to quantify behavior. In PEST, participants rate a series of phishing and non-phishing emails according to their level of suspicion. By comparing suspicion scores for each email to its real-world efficacy, we find initial support for the ecological validity of PEST - phishing emails that were more effective in the real world were more effective at deceiving people in the lab. In the proposed computational model, we quantify behavior in terms of participants' overall level of suspicion of emails, their ability to distinguish phishing from non-phishing emails, and the extent to which emails from the recent past bias their current decision. Together, our task and model provide a framework for studying the cognitive neuroscience of phishing detection.

4.
Dalton Trans ; 2020 Oct 12.
Artigo em Inglês | MEDLINE | ID: mdl-33043952

RESUMO

A new metal-organic framework (MOF), [Eu2(HBDPP)2(H2O)2(DMF)2](H2O)2 (H4BDPP = 3,5-bis(3,5-dicarboxylphenyl) pyridine; DMF = N,N-dimethylformamide) (Eu-MOF), has been successfully synthesized under solvothermal conditions. A 1D chain was formed by the adjacent Eu2(COO)24+ dinuclear cluster and HBDPP3-, and further connected by HBDPP3- to form an infinitely extended 3D structure. In order to further improve the proton conductivity of the Eu-MOF, imidazole was encapsulated in its pores to form a composite material named Im@Eu-MOF. AC impedance analysis shows that the highest proton conductivity of the Im@Eu-MOF reaches up to 4.53 × 10-4 S cm-1 at 348 K and 98% RH, which is about 10 times higher than that of the Eu-MOF. In addition, the Eu-MOF can be considered an excellent luminescence-based sensor with a high sensitivity and low detection limit (0.1 µM) for the detection of trace amounts of ascorbic acid.

5.
J Orthop Surg Res ; 15(1): 384, 2020 Sep 04.
Artigo em Inglês | MEDLINE | ID: mdl-32887611

RESUMO

BACKGROUND: The positional distribution and size of the weight-bearing area of the femoral head in the standing position as well as the direct active surface of joint force can directly affect the result of finite element (FE) stress analysis. However, the division of this area was vague, imprecise, and un-individualized in most studies related to separate FE models of the femur. The purpose of this study was to quantify the positional distribution and size of the weight-bearing area of the femoral head in standing position by a set of simple methods, to realize individualized reconstruction of the proximal femur FE model. METHODS: Five adult volunteers were recruited for an X-ray and CT examination in the same simulated bipedal standing position with a specialized patented device. We extracted these image data, calculated the 2D weight-bearing area on the X-ray image, reconstructed the 3D model of the proximal femur based on CT data, and registered them to realize the 2D weight-bearing area to 3D transformation as the quantified weight-bearing surface. One of the 3D models of the proximal femur was randomly selected for finite element analysis (FEA), and we defined three different loading surfaces and compared their FEA results. RESULTS: A total of 10 weight-bearing surfaces in 5 volunteers were constructed, and they were mainly distributed on the dome and anterolateral of the femoral head with a crescent shape, in the range of 1218.63-1,871.06 mm2. The results of FEA showed that stress magnitude and distribution in proximal femur FE models among three different loading conditions had significant differences, and the loading case with the quantized weight-bearing area was more in accordance with the physical phenomenon of the hip. CONCLUSION: This study confirmed an effective FE modeling method of the proximal femur, which can quantify the weight-bearing area to define a more reasonable load surface setting without increasing the actual modeling difficulty.

6.
JAMA Psychiatry ; 2020 Sep 30.
Artigo em Inglês | MEDLINE | ID: mdl-32997097

RESUMO

Importance: Polygenic risk scores (PRS) are predictors of the genetic susceptibilities of individuals to diseases. All individuals have DNA risk variants for all common diseases, but genetic susceptibility differences between people reflect the cumulative burden of these. Polygenic risk scores for an individual are calculated as weighted counts of thousands of risk variants that they carry, where the risk variants and their weights have been identified in genome-wide association studies. Here, we review the underlying basic science of PRS, providing a foundation for understanding the potential clinical utility and limitations of PRS. Observations: Polygenic risk scores can be calculated for a wide range of diseases from a saliva or blood sample using genotyping technologies that are inexpensive. While genotyping only needs to be done once for each individual in their lifetime, the PRS can be recalculated as identification of risk variants improves. On their own, PRS will never be able to establish or definitively predict future diagnoses of common complex conditions because genetic factors only contribute part of the risk, and PRS will only ever capture part of the genetic contributions. Nonetheless, just as clinical medicine uses a multitude of other predictive measures, PRS either on their own or as part of multivariable predictive algorithms could play a role. Conclusions and Relevance: Utility of PRS in clinical medicine and ethical issues related to their use should be evaluated in the context of realistic expectations of what PRS can and cannot deliver. For different diseases, PRS could have utility in community settings (stratification to better triage people into established screening programs) or could contribute to clinical decision-making for those presenting with symptoms but where formal diagnosis is unclear. In principle, PRS could contribute to treatment choices, but more data are needed to allow development of PRS in this context.

7.
Bioorg Chem ; 102: 104101, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-32721778

RESUMO

Three new carbazole alkaloids, zanthoaustrones A-C (1-3), as well as nine known compounds 4-12, were isolated and characterized from the roots of Zanthoxylum austrosinense Huang (Rutaceae). Their chemical structures were elucidated on the basis of extensive and comprehensive spectroscopic methods, while the known alkaloids were identified by the comparison of their observed spectroscopic data including NMR data, MS data and optical rotation values with the data described in the literature. Furthermore, the antiproliferative activities as well as the anti-inflammatory effects of all isolated alkaloids in vitro were evaluated. All obtained alkaloids 1-12 displayed notable antiproliferative activities against diverse human cancer cell lines exhibiting IC50 values in range of 0.85 ± 0.06 to 29.56 ± 0.17 µM, which is equivalent to the positive control (cisplatin) showing IC50 values ranging from 1.58 ± 0.09 to 28.69 ± 0.21 µM. Moreover, compounds 1-12 exhibited pronounced inhibitory activities on nitric oxide (NO) production with IC50 values displaying IC50 values in range of 0.89 ± 0.05 to 9.62 ± 0.15 µM, which is comparable to the positive control (hydrocortisone) holding an IC50 value of 4.06 ± 0.11 µM. These findings indicate that the separation and characterization of these alkaloids displaying significant antiproliferative activities together with anti-inflammatory effects from the roots of Z. austrosinense could be meaningful to the research and development of new anti-cancer drugs as well as anti-inflammatory agents.

8.
Theranostics ; 10(17): 7545-7560, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32685004

RESUMO

Rationale: Peritoneal metastasis predicts poor prognosis of gastric cancer (GC) patients, and the underlying mechanisms are poorly understood. Methods: The 2-DIGE, MALDI-TOF/TOF MS and single-cell transcriptome were used to detect differentially expressed proteins among normal gastric mucosa, primary GC and peritoneal metastatic tissues. Lentiviruses carrying shRNA and transcription activator-like effector nuclease technology were used to knock down myosin heavy chain 9 (MYH9) expression in GC cell lines. Immunofluorescence, immune transmission electron microscopy, chromatin fractionation, co-immunoprecipitation, and assays for chromatin immunoprecipitation, dual luciferase reporter, agarose-oligonucleotide pull-down, flow cytometry and cell anoikis were performed to uncover nuclear MYH9-induced ß-catenin (CTNNB1) transcription in vitro. Nude mice and conditional transgenic mice were used to investigate the findings in vivo. Results: We observed that MYH9 was upregulated in metastatic GC tissues and was associated with a poor prognosis of GC patients. Mechanistically, we confirmed that MYH9 was mainly localized in the GC cell nuclei by four potential nuclear localization signals. Nuclear MYH9 bound to the CTNNB1 promoter through its DNA-binding domain, and interacted with myosin light chain 9, ß-actin and RNA polymerase II to promote CTNNB1 transcription, which conferred resistance to anoikis in GC cells in vitro and in vivo. Staurosporine reduced nuclear MYH9 S1943 phosphorylation to inhibit CTNNB1 transcription, Wnt/ß-catenin signaling activation and GC progression in both orthotropic xenograft GC nude mouse and transgenic GC mouse models. Conclusion: This study identified that nuclear MYH9-induced CTNNB1 expression promotes GC metastasis, which could be inhibited by staurosporine, indicating a novel therapy for GC peritoneal metastasis.

9.
Medicine (Baltimore) ; 99(24): e20549, 2020 Jun 12.
Artigo em Inglês | MEDLINE | ID: mdl-32541477

RESUMO

BACKGROUND: Despite rapid reports on the correlation between body mass index (BMI) and periprosthetic joint infection (PJI) after total joint arthroplasty, some have conducted regression tests or meta-analyses with controversial results. In this study, we systematically meta-analyzed relevant trials and carefully evaluated the correlation for verification. METHODS: Literature on the correlation between BMI and PJI following total joint arthroplasty was retrieved in PubMed, Embase and Cochrane Library due September 2019. Stata 13.0 software was adopted for data synthesis and analyses of publication bias and sensitivity. Random-effect models were used to summary the overall estimate of the multivariate adjusted odds ratio (OR)/hazard ratio/rate ratio with 95% confidence intervals (CIs). RESULTS: A total of 29 observational studies representing 3,204,887 patients were included. The meta-analysis revealed that the risk of postoperative PJI significantly increased by 1.51 times in the obese group (OR = 1.51; 95% CI = 1.30-1.74 for the obese group vs. the non-obese group), and by 3.27 times in the morbid obese group (OR = 3.27; 95% CI = 2.46-4.34 for the morbid obese group vs the non-morbid obese group). A significant association remained consistent, as indicated by subgroup analyses and sensitivity analyses. CONCLUSION: Our findings demonstrate that postoperative PJI is positively correlated with BMI, with obese patients showing a greater risk of developing PJI than non-obese patients. Similarly, morbid obese patients present a higher risk of PJI than non-morbid obese patients. However, this conclusion needs to be corroborated by more prospective studies.


Assuntos
Artrite Infecciosa/etiologia , Índice de Massa Corporal , Obesidade/complicações , Infecções Relacionadas à Prótese/etiologia , Humanos , Metanálise como Assunto , Revisões Sistemáticas como Assunto
10.
Oral Oncol ; 108: 104820, 2020 09.
Artigo em Inglês | MEDLINE | ID: mdl-32531741

RESUMO

OBJECTIVES: We investigated the survival impacts of various nodal characteristics and T-classification on nasopharyngeal carcinoma (NPC) patients with the 8th AJCC/UICC staging criteria N3. MATERIALS AND METHODS: Pretreatment MRIs from 110 staged N3 NPC patients were reviewed. There were 23 T1, 25 T2, 32 T3, and 30 T4, respectively. All except one patient belonged to WHO type II pathology. All patients received curative radiotherapy 68.0-76.8 Gy plus different chemotherapy, including induction, concurrent, adjuvant or any combination. Various endpoints, including OS (overall survival), DFS (disease-free survival), LRFFS (locoregional failure-free survival), DMFFS (distant metastasis failure-free survival) were compared between different nodal characteristics and T-classification. RESULTS: There were no statistically significant differences in all analyzed survival curves between various nodal characteristics, including unilateral N3 vs. bilateral N3, "large" nodes (>6 cm) alone vs. "low" nodes (below the caudal border of cricoid cartilage) alone vs. combined "large" and "low" nodes, risk score 1 vs. 2 vs. 3 vs. 4 (by counting the sum of "large" and "low" nodes in the same case), and radiologic extra-nodal extension. Patients with T4, compared with those of T1-3 have worse OS (5-year rates, 42.2% vs. 82.8%, P < 0.0001), DFS (5-year rates, 43.9% vs. 68.9%, P = 0.0037), LRFFS (5-year rates, 69.3% vs. 82.7%, P = 0.0432), and DMFFS (5-year rates, 57.2% vs. 77.7%, P = 0.0163). CONCLUSIONS: Our results support merging previous N3a and N3b as a N3 category in the 8th edition new staging system. Patients with T4N3 diseases have extremely poor outcome and deserve to strengthen the treatment intensity in future trials.

11.
Biomed Res Int ; 2020: 7348745, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32382569

RESUMO

The present study aimed to investigate the effect of microglia on simulated microgravity-induced hippocampal neurogenesis reduction and the possible mechanism underlying. Adult rats were treated with tail suspension for different times and the changes of neural stem cells (NSCs) were examined by immunohistochemistry. Then, minocycline was used to inhibit the activation of microglia, and the numbers of microglia and NSCs were detected after microgravity. Additionally, liquid protein chip analysis was applied to detect proinflammatory factors in hippocampus in order to find out the cytokines responsible for microglia activation after microgravity. The results revealed that microgravity increased the numbers of Iba1+ cells and decreased the numbers of BrdU+ and DCX+ cells in hippocampus but did not affect the ratio of NeuN+/BrdU+ cells to the total number of BrdU+ cells. After treated with minocycline, activated microglia were suppressed and the reduction of NSCs induced by microgravity recovered. Besides, compared with the control, higher concentrations of INF-γ and TNF-α were detected in the rats treated with microgravity. Our study provides the first evidence that microglia-mediated inflammation plays an important part in microgravity-induced neurogenesis reduction in hippocampus, and INF-γ and TNF-α secreted by microglia might be the key factors in this process.

12.
Sci Total Environ ; 727: 138408, 2020 Jul 20.
Artigo em Inglês | MEDLINE | ID: mdl-32335448

RESUMO

The occurrence and air-sea gas exchange of hexachlorocyclohexanes (HCHs), dichlorodiphenyltrichloroethanes (DDTs), and chlordanes were determined in the Northwest Pacific Ocean (NWP) in spring to elucidate their current pollution status and fate. ΣHCHs, ΣDDTs, and Σchlordanes in air (sum of gaseous and aerosol phase) ranged from 9.37 to 102, from 1.73 to 12.8, and from 0.24 to 14.9 pg/m3, respectively, with their dissolved levels being 30.7-518, 7.10-80.5, and 0.25-7.10 pg/L, respectively. HCHs, DDTs, and chlordanes cause substantial contamination of the air and seawater of the East China Sea (ECS), indicating significant OCP inputs from China. Isomer ratios of HCHs and DDTs provided a fingerprint of East Asian emissions of legacy OCPs, with the pollution profiles of HCHs and DDTs dominated by lindane and combined dicofol-type and weathered technical DDTs, respectively. The former result is consistent with the apparent decline in air α-HCH levels over the ECS. Different from still net deposition of gaseous α- and γ-HCH in the NWP, outgassing of trans-chlordane, cis-chlordane, and DDTs other than dicofol-sourced o,p'-DDT was indicated. This observation attributes to intensive historical usage of technical HCHs and the prevalence of lindane pollution in East Asia, and demonstrates the transitioning role of seawater as a source for residual OCPs in the East Asia-NWP region. Significant subcooled liquid vapor pressure-based relationships for legacy OCPs were identified mainly in marine air masses; these were different from land-sourced polybrominated diphenyl ethers, and suggested a heterogeneous role of ocean- and land-based sources in atmospheric partitioning of these pollutants.

13.
Nat Commun ; 11(1): 1647, 2020 04 02.
Artigo em Inglês | MEDLINE | ID: mdl-32242144

RESUMO

Vitamin D deficiency is a candidate risk factor for a range of adverse health outcomes. In a genome-wide association study of 25 hydroxyvitamin D (25OHD) concentration in 417,580 Europeans we identify 143 independent loci in 112 1-Mb regions, providing insights into the physiology of vitamin D and implicating genes involved in lipid and lipoprotein metabolism, dermal tissue properties, and the sulphonation and glucuronidation of 25OHD. Mendelian randomization models find no robust evidence that 25OHD concentration has causal effects on candidate phenotypes (e.g. BMI, psychiatric disorders), but many phenotypes have (direct or indirect) causal effects on 25OHD concentration, clarifying the epidemiological relationship between 25OHD status and the health outcomes examined in this study.


Assuntos
Deficiência de Vitamina D/genética , Vitamina D/análogos & derivados , Adulto , Idoso , Grupo com Ancestrais do Continente Europeu/genética , Feminino , Estudo de Associação Genômica Ampla , Humanos , Masculino , Análise da Randomização Mendeliana , Pessoa de Meia-Idade , Polimorfismo de Nucleotídeo Único , Reino Unido , Vitamina D/sangue , Deficiência de Vitamina D/sangue
14.
Environ Pollut ; 263(Pt B): 114426, 2020 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-32224384

RESUMO

As emerging pollutants, the occurrence and risks of organophosphate esters (OPEs) in mariculture farms should be concerned; however, information is limited. Beibu Gulf is one of the essential mariculture zones in China. This study aimed to investigate the occurrence of OPEs in mariculture farms of the Beibu Gulf, their phase distribution and bioaccumulation among sediment, organisms (shrimp, crab, and oyster), water, and feed. Human exposure to OPEs through seafood consumption was also assessed. The total concentrations of the 11 target OPEs (∑11OPEs) in the water samples ranged 32.9-227 ng L-1. It was significantly higher in water from the culture ponds (mean 122 ng L-1) than in water from the estuaries and nearshore areas (mean 51.1 ng L-1) (nonparametric test, p < 0.05). ∑11OPEs in the feeds averaged 46.0 (range 21.7-84.5) ng g-1 dw, which is similar to the level in the organism samples (mean 55.5, range 21.3-138 ng g-1 dw) and 4.4 times higher than that in the sediment (mean 10.9, range 35-22.1 ng g-1 dw). The ∑11OPEs released from the feeds to the culture ponds was estimated to be 49 µg m-2 per three-month period. In the aquaculture ponds, the sediment-water distribution coefficient (log KOC), and the bioaccumulation factors from the water (log BWAFs) or the feed (log BFAFs) to the organisms, depend linearly on the hydrophobicity (log KOW) of OPEs. The log BWAFs and log BFAFs increased with increasing log KOW within the log KOW range of 1-7. The human exposure to OPEs through consumption of shrimp, crab, and oysters from the mariculture farms does not pose a health risk at present.


Assuntos
Monitoramento Ambiental , Poluentes Químicos da Água/análise , Aquicultura , Bioacumulação , China , Ésteres , Humanos , Organofosfatos , Medição de Risco
15.
Cell Death Dis ; 11(3): 202, 2020 Mar 23.
Artigo em Inglês | MEDLINE | ID: mdl-32205841

RESUMO

Tumor microenvironment plays vital roles in shaping cancer diversity, and CD73 (ecto-5'-nucleotidase; NT5E) is an emerging immune checkpoint in modulating cancer progression via conversion of immunostimulatory ATP into immunosuppressive adenosine. However, how the CD73 is regulated and how it functions in the progression of cancer are largely unknown. Here, we showed that CD73 was overexpressed and correlated with poor prognosis of gastric cancer. CD73 links adenosinergic signaling in microenvironment switching to induction of epithelial-to-mesenchymal transition phenotype in gastric cancer during metastasis. Further pathway and gene set enrichment analysis of transcriptome data revealed the modulation role of CD73 in RICS/RhoA signaling by its extracellular function in adenosinergic pathway, which subsequently inhibited phosphorylation of LIMK/cofilin and promoted ß-catenin activation. Pharmacological inhibition of CD73 adenosinergic signaling was found to induce RICS dysfunction. Dissemination and hematogenous metastasis model showed that targeting CD73 in gastric cancer could suppress experimental metastasis. To conclude, it substantiates CD73 as a target for treatment of gastric cancer metastasis and verifies RICS as an intracellular functional molecule linking CD73/adenosinergic signaling switching to RhoA/LIMK/cofilin pathway.

16.
BMC Cancer ; 20(1): 220, 2020 Mar 14.
Artigo em Inglês | MEDLINE | ID: mdl-32171265

RESUMO

BACKGROUND: To retrospectively investigate the clinical characteristics, initial treatment, relapse, therapy outcome, and prognosis of Chinese patients with primary testicular lymphoma (PTL) through analysis of the cases of our institute. METHODS: From December 2008 to July 2018, all patients with PTL were included in this study. Kaplan-Meier method was used to estimate PFS and OS. The Cox proportional hazards model was used to compare the survival times for groups of patients differing in terms of clinical and laboratory parameters. RESULTS: All 28 PTL patients (24 DLBCL, three NK/T lymphomas, and one Burkkit's lymphoma) with a median age of 65.5 years were included in this study. Six patients were observed recurrence among all the 22 individuals evaluated. Following orchiectomy and systemic chemotherapy, with or without intrathecal prophylaxis, complete response was achieved in 15 (68%) patients. For DLBCL patients, the median progression-free survival (PFS) was 44.63 months (95% CI 17.71-71.56 months), and the median overall survival (OS) was 77.02 months (95% CI, 57.35-96.69 months). For all the DLBCL patients, the 5-year PFS and 5-year OS were 35.4% (95%CI, 14.8-56.0%) and 53.4% (95%CI, 30.1-76.7%). Without further chemotherapy following orchiectomy (HR = 3.4, P = 0.03) were associated with inferior PFS of DLBCL patients. Advanced Ann Arbor stage (HR =5.9, P = 0.009) and high (international prognostic index, IPI) score: 3-5 (HR =3.9, P = 0.04) were correlated with shorter OS of DLBCL patients. CONCLUSION: This study confirms that PTL is an aggressive malignant with a poor prognosis. Limited Ann Arbor stage, further chemotherapy following orchiectomy, and low IPI score (less than 2) are correlated with superior survival for DLBCL patients.

17.
Environ Pollut ; 262: 114139, 2020 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-32120253

RESUMO

We investigated the levels and distributions of organochlorine pesticides (OCPs) in 159 background soil samples collected from 30 forested mountain sites across China. The sum of DDT was the most abundant OCP, with the concentrations of 0.197-207 ng/g and 0.033-122 ng/g in the O-horizon and A-horizon, respectively. High concentrations of OCPs usually occur near agricultural regions or high consumption areas. The spatial distribution was mainly influenced by the emission sources and soil total organic contents (TOC). The chiral compounds were generally nonracemic in the soils and showed preferential degradation of (-) o,p'- dichlorodiphenyltrichloroethane, (+) trans-chlordane, and (-) cis-chlordane in both the O- and A-horizons. The enantiomeric fraction (EF) distributions of chiral OCPs displayed no differences across the forest sites in the O-horizon or the A-horizon. Comparing the deviation of EFs from racemic (DEVrac = absolute value of 0.500 - EF) with environmental parameters, we found that DEVrac of cis-chlordane demonstrated a strong positive correlation with TOC (p < 0.05) and the C/N ratio (p < 0.01). This relationship suggests that these factors could affect the microbial activity and significantly impact the extent of enantioselective degradation of chiral compounds in the soils. Fresh and historical applications of DDT and historical chlordane and endosulfan uses may be prominent sources of OCP accumulation in Chinese forest soils.


Assuntos
Hidrocarbonetos Clorados/análise , Praguicidas/análise , Poluentes do Solo/análise , China , Monitoramento Ambiental , Florestas , Solo , Estereoisomerismo
18.
Environ Pollut ; 263(Pt A): 114391, 2020 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-32213363

RESUMO

Per- and polyfluoroalkyl substances (PFASs) contamination in the Bohai Sea and its surrounding rivers has attracted considerable attention in recent years. However, few studies have been conducted regarding the distribution of PFASs in multiple environmental media and their distributions between the suspended particles and dissolved phases. In this study, surface water, surface sediment, and air samples were collected at the Bohai Sea to investigate the concentration and distribution of 39 targeted PFASs. Moreover, river water samples from 35 river estuaries were collected to estimate PFAS discharge fluxes to the Bohai Sea. The results showed that total ionic compound (Σi-PFASs) concentrations ranged from 19.3 to 967 ng/L (mean 125 ± 152 ng/L) in the water and 0.70-4.13 ng/g dw (1.78 ± 0.76 ng/g) in surface sediment of the Bohai Sea, respectively. In the estuaries, Σi-PFAS concentrations were ranged from 10.5 to 13500 ng/L (882 ± 2410 ng/L). In the air, ΣPFAS (Σi-PFASs + Σn-PFASs) concentrations ranged from 199 to 678 pg/m3 (462 ± 166 pg/m3). Perfluorooctanoic acid (PFOA) was the predominant compound in the seawater, sediment, and river water; in the air, 8:2 fluorotelomer alcohol was predominant. Xiaoqing River discharged the largest Σi-PFAS flux to the Bohai Sea, which was estimated as 12,100 kg/y. Some alternatives, i.e., 6:2 fluorotelomer sulfonate acid (6:2 FTSA), hexafluoropropylene oxide dimer acid (HFPO-DA), and chlorinated 6:2 polyfluorinated ether sulfonic acid (Cl-6:2 PFESA), showed higher levels than or comparable concentrations to those of the C8 legacy PFASs in some sampling sites. The particle-derived distribution coefficient in seawater was higher than that in the river water. Using high resolution mass spectrometry, 29 nontarget emerging PFASs were found in 3 river water and 3 seawater samples. Further studies should be conducted to clarify the sources and ecotoxicological effects of these emerging PFASs in the Bohai Sea area.


Assuntos
Fluorcarbonetos/análise , Poluentes Químicos da Água/análise , China , Monitoramento Ambiental , Rios , Água do Mar , Água
19.
Bioorg Chem ; 97: 103699, 2020 04.
Artigo em Inglês | MEDLINE | ID: mdl-32146173

RESUMO

The phytochemical study on the stems of Clausena lenis resulted in the isolation of three new prenylated coumarins, clauselenins A-C (1-3), together with nine known prenylated coumarins (4-12). The chemical structures of new prenylated coumarins (1-3) were elucidated by means of comprehensive spectral analyses and the known compounds (4-12) were determined by means of comparing their experimental spectral data with those described data in the literatures. All isolated prenylated coumarins were assessed for their anti-inflammatory effects together with anti-HIV activities in vitro. Prenylated coumarins 1-12 displayed remarkable inhibitory effects against nitric oxide (NO) production induced by lipopolysaccharide in mouse macrophage RAW 264.7 cells in vitro with the IC50 values which are comparable to hydrocortisone. Meanwhile, prenylated coumarins 1-12 exhibited considerable anti-HIV-1 reverse transcriptase (RT) activities possessing EC50 values in the range of 0.17-9.08 µM. These findings indicate that the isolation and identification of these prenylated coumarins with pronounced anti-inflammatory effects as well as anti-HIV activities separated from the stems of C. lenis could be of great significance to the development of new anti-inflammatory and anti-HIV agents and their potential applications in the pharmaceutical industry.

20.
Int J Mol Sci ; 21(3)2020 Feb 03.
Artigo em Inglês | MEDLINE | ID: mdl-32028746

RESUMO

Acute kidney injury (AKI) causes over 1 million deaths worldwide every year. AKI is now recognized as a major risk factor in the development and progression of chronic kidney disease (CKD). Diabetes is the main cause of CKD as well. Renal fibrosis and inflammation are hallmarks in kidney diseases. Various cytokines contribute to the progression of renal diseases; thus, many drugs that specifically block cytokine function are designed for disease amelioration. Numerous studies showed IL-20 functions as a pro-inflammatory mediator to regulate cytokine expression in several inflammation-mediated diseases. In this review, we will outline the effects of pro-inflammatory cytokines in the pathogenesis of AKI and CKD. We also discuss the role of IL-20 in kidney diseases and provide a potential therapeutic approach of IL-20 blockade for treating renal diseases.

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