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1.
ACS Appl Mater Interfaces ; 9(49): 42471-42481, 2017 Dec 13.
Artigo em Inglês | MEDLINE | ID: mdl-29140069

RESUMO

Four phosphorescent cyclometalated iridium(III) complexes containing benzimidazole moiety have been designed and synthesized. These Ir(III) complexes can effectively inhibit several cancerous processes, including cell migration, invasion, colony formation, and angiogenesis. Interestingly, they show a much higher singlet oxygen quantum yield in an acidic solution than in a neutral solution. Upon irradiation at 425 nm with low energy (1.2 J cm-2), they can induce apoptosis through lysosomal damage, evaluation of reactive oxygen species level, and activation of caspase-3/7. The highest phototoxicity index is >476, with almost no dark cytotoxicity observed for Ir4. Ir4 can also inhibit tumor growth effectively in nude mice in vivo after photodynamic therapy. An in vitro assay against 70 kinases indicates that maternal embryonic leucine zipper kinase (MELK), PIK3CA, and AMPK are the possible molecular targets. The half maximal inhibitory concentration of Ir4 toward MELK is 1.27 µM. Our study demonstrates that these Ir(III) complexes are promising anticancer agents with dual functions, including metastasis inhibition and lysosome-damaged photodynamic therapy.


Assuntos
Irídio/química , Animais , Complexos de Coordenação , Células HeLa , Humanos , Lisossomos , Camundongos , Camundongos Nus , Fotoquimioterapia
2.
Chem Commun (Camb) ; 51(39): 8353-6, 2015 May 14.
Artigo em Inglês | MEDLINE | ID: mdl-25882790

RESUMO

In this report, we designed a histone deacetylase-targeted phosphorescent Re(I) complex ReLMito. Colocalization studies suggested that ReLMito could specially localize to mitochondria. We also demonstrated that ReLMito could induce paraptosis in cancer cells. These features endowed the complex with potential to induce and monitor mitochondrial morphological changes during the paraptosis simultaneously.


Assuntos
Complexos de Coordenação/farmacologia , Inibidores de Histona Desacetilases/farmacologia , Mitocôndrias/metabolismo , Piridinas/farmacologia , Rênio/farmacologia , Amidas/química , Amidas/farmacologia , Apoptose/efeitos dos fármacos , Complexos de Coordenação/química , Células HeLa , Inibidores de Histona Desacetilases/química , Histona Desacetilases/metabolismo , Histonas/metabolismo , Humanos , Piridinas/química , Rênio/química
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