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1.
Curr Med Sci ; 41(1): 77-83, 2021 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-33582909

RESUMO

The Coronavirus disease 2019 (COVID-19) outbreak has been brought under control through a nationwide effort, and now it has become a global pandemic and the situation seems grim. We summarized the measures taken in Wuhan and analyzed the effects to comprehensively describe the factors involved in controlling the COVID-19 in China. In China, several measures such as the lockdown of Wuhan, restriction of traffic and communities, increasing hospital beds, nationwide support from medical staff, epidemic prevention equipment and supplies, and establishment of makeshift shelter hospitals have been taken. The lockdown of Wuhan reduced the propagation of cases to other cities in Hubei province and throughout China, traffic and community restrictions reduced the flow of population and the spread of disease, increasing wards and beds and medical personnel reduced the incidence of severe cases and mortality, the establishment of the Fangcang shelter hospitals provided a good isolation and monitoring environment, and further reduced the spread and fatality of the disease. The fact that China was able to control the spread of COVID-19 within three months without a specific drug or vaccine suggests that these measures are more adequate and effective.


Assuntos
/prevenção & controle , Controle de Doenças Transmissíveis/métodos , Pandemias/prevenção & controle , /transmissão , China , Controle de Doenças Transmissíveis/instrumentação , Feminino , Humanos , Masculino
2.
Bioresour Technol ; 321: 124460, 2020 Dec 05.
Artigo em Inglês | MEDLINE | ID: mdl-33307482

RESUMO

An outdoor anaerobic fermentation reactor loses a significant amount of energy due to heat dissipation to the surrounding environment. The digester of direct absorption biogas can effectively utilize solar energy and scattering of the medium to enhance reaction temperature, which can promote anaerobic fermentation of microorganisms. A numerical model for the direct absorption methane digester was established to investigate the mechanism of photo biochemical transformation. The average relative values of simulated results were 4.1% and 9.6%, indicating that the model can effectively simulate the heat transfer process of biogas slurry under solar irradiation. Decreasing the albedo and increasing the effect of forward scattering of small particles can improve the regenerative performance and biogas production of digester. Increasing the backward scattering effect of small particles limited biogas fermentation. Scattering distribution had bigger effects on the rates of biogas and propionic acid production than those of albedo.

3.
Zhongguo Shi Yan Xue Ye Xue Za Zhi ; 28(6): 2039-2045, 2020 Dec.
Artigo em Chinês | MEDLINE | ID: mdl-33283739

RESUMO

OBJECTIVE: To compare the effect of Sheng-Xue-Xiao-Ban Capsule (SXXBC) and indirubin to the peripheral platelets of the Idiopathic thrombocytopenic purpura (ITP) model mouse. METHODS: The ITP mouse model was established by the method of passive immunization. SXXBC and indirubin were used for intervention treatment. Then the hemorrhagic phenomena of ITP mice were observed and the numbers of peripheral platelets, hemoglobin and white blood cells, bone marrow megakaryocytes and their classification and coagulation function were detected and compared. RESULTS: The improvement rate of hemorrhage in SXXBC group was 40% for small dose, 60% for medium dose and 80% for high dose, while the improvement rate of hemorrhage in indirubin group was 30% for small dose, 50% for medium dose and 60% for high dose. There was no statistically significant difference in the improvement rate of hemorrhage between the two groups (P>0.05). Compared with the model control group, PLT and Hb increased in different doses of SXXBC and indirubin group 4th-8th day after drug intervention (P<0.05, 0.01). However, there was no significant difference between the different doses of SXXBC group and indirubin group (P>0.05). Compared with the model control group, the WBC in each group was significantly lower (P<0.05, 0.01) on the 4th-8th day after drug intervention; However, there was no statistical significance between the two groups of SXXBC and indirubin (P>0.05). Compared with the model control group, the total number of megakaryocytes in each treatment group were decreased (P<0.05, P<0.01), in which the number of primary megakaryocytes in the large and medium dose groups of SXXBC and indirubin were decreased (P<0.05, 0.01), and the number of juvenile megakaryocytes in the large dose group of SXXBC and indirubin were also decreased (P<0.05). The number of granular megakaryocytes were decreased in each intervention groups (P<0.05, 0.01), and the number of thromocytogenic megakaryocyte was increased in the high and medium dose groups of SXXBC and indirubin (P<0.01). The time of prothrombin was shortened in the high and medium dose groups of SXXBC and indirubin (P<0.05), and the fibrinogen (FIB) content in the high and medium dose groups of SXXBC was close to that of the normal control group. CONCLUSION: Both of the SXXBC and the indirubin standard all show good hemostatic effects. Indirubin shows a positive effect on increasing the peripheral platelet and hemoglobin in ITP model mice, regulating the immune response, reducing the total number of bone marrow megakaryocytes, increasing the thromocytogenic megakaryocyte, and increasing coagulation function.

4.
Biol Reprod ; 2020 Sep 21.
Artigo em Inglês | MEDLINE | ID: mdl-33106855

RESUMO

Actinomycin D (ActD) has been considered as one of the most effective and safe chemotherapeutic medications for treating a number of cancers. Although ActD has been used in the treatment of gynecological tumors and pediatric tumors for more than 50 years, the toxic effects of ActD on mammalian oocytes remain unknown. In this study, the influence of ActD on mouse and human oocyte maturation and the possible mechanisms were investigated. Notably, ActD inhibited oocyte maturation and arrested oocytes at the metaphase I (MI) stage in a dose-dependent manner. In addition, ActD arrested oocyte maturation when the oocytes were treated at different successive stages, including the germinal vesicle (GV), germinal vesicle breakdown, and MI stages. In ActD-treated oocytes, disordered chromosome condensation and irregular spindle assembly occurred, resulting in incomplete chromosome segregation and oocytes arresting at the MI phase; these results possibly occurred because ActD triggered the formation of reactive oxygen species, resulting in DNA damage and decreased ATP in mouse GV oocytes. Besides, in vivo treatment with ActD also inhibited mouse oocyte maturation. Similar effects were seen in human oocytes. Collectively, our results indicated that ActD exposure disrupted oocyte maturation by increasing DNA damage, which is a finding that might help with optimizing future methods for female fertility preservation before undergoing chemotherapy.

6.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao ; 42(3): 370-375, 2020 Jun 30.
Artigo em Chinês | MEDLINE | ID: mdl-32616134

RESUMO

Objective To investigate the computed tomographc(CT)features of mild/moderate and severe/critical cases of coronavirus disease 2019(COVID-19)in the recovery phase. Methods Totally 63 discharged patients in Wuhan,China,who underwent both chest CT and reverse transcription-polymerase chain reaction(RT-PCR)from February 1 to February 29,2020,were included.With RT-PCR as a gold standard,the performance of chest CT in diagnosing COVID-19 was assessed.Patients were divided into mild/moderate and severe/critical groups according to the disease conditions,and clinical features such as sex,age,symptoms,hospital stay,comorbidities,and oxygen therapy were collected.CT images in the recovery phase were reviewed in terms of time from onset,CT features,location of lesions,lobe score,and total CT score. Results There were 37 patients in the mild/moderate group and 26 in the severe/critical group. Compared with the mild/moderate patients,the severe/critical patients had older age [(43±16) years vs. (52±16) years; t=2.10, P=0.040], longer hospital stay [(15±6)d vs. (19±7)d; t=2.70, P=0.009], higher dyspnea ratio (5.41% vs. 53.85%; χ2=18.90, P<0.001), lower nasal oxygen therapy ratio (81.08% vs. 19.23%;χ2=23.66, P<0.001), and higher bi-level positive airway pressure ventilation ratio (0 vs. 57.69%; χ2=25.62, P<0.001). Time from onset was (23±6) days in severe/critical group, significantly longer than that in mild/moderate group [(18±7) days] (t=3.40, P<0.001). Severe/critical patients had significantly higher crazy-paving pattern ratio (46.15% vs.10.81%;χ2=4.24, P=0.039) and lower ground-glass opacities ratio (15.38% vs. 67.57%; χ2=16.74, P<0.001) than the mild/moderate patients. The proportion of lesions in peripheral lung was significantly higher in mild/moderate group than in severe/critical group (78.38% vs.34.61%; χ2=13.43, P<0.001), and the proportion of diffusely distributed lesions was significantly higher in severe/critical group than in mild/moderate group (65.38% vs.10.81%; χ2=20.47, P<0.001). Total CT score in severe/critical group was also significantly higher in severe/critical group than in mild/moderate group [11 (8,17) points vs. 7 (4,9) points; Z=3.81, P<0.001]. Conclusions The CT features in the recovery stage differ between mild/moderate and severe/critical COVID-19 patients.The lung infiltration is remarkably more severe in the latter.


Assuntos
Betacoronavirus , Infecções por Coronavirus , Pandemias , Pneumonia Viral , Adulto , Idoso , China , Infecções por Coronavirus/diagnóstico por imagem , Humanos , Pessoa de Meia-Idade , Pneumonia Viral/diagnóstico por imagem , Estudos Retrospectivos , Tomografia Computadorizada por Raios X
7.
Surg Today ; 50(9): 1113-1116, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-32700004

RESUMO

Managing patients with pulmonary contusion safely and effectively during the coronavirus disease 2019 (COVID-19) pandemic is challenging. This retrospective study analyzes the clinical data of 29 consecutive patients with pulmonary contusion, including two with COVID-19, at Tongji Hospital, Wuhan, China, in January and February, 2020. We analyzed the clinical manifestations, laboratory test results, computed tomography (CT) images, treatment, and clinical outcomes. The two patients with pulmonary contusion and COVID-19 had increased leukocyte and neutrophil counts, similar to the patients with pulmonary contusion alone. Interestingly, both these patients had subpleural ground glass opacity on CT images as a typical manifestation of COVID-19. All 29 patients were treated conservatively, including with closed thoracic drainage, instead of with thoracotomy. Six patients died of ARDS or craniocerebral injury, but the others stabilized. During the COVID-19 pandemic, patients with pulmonary contusion should be tested for SARS-CoV-2 and unless critical, thoracotomy should be avoided.


Assuntos
Betacoronavirus , Contusões/diagnóstico por imagem , Contusões/virologia , Infecções por Coronavirus/complicações , Infecções por Coronavirus/diagnóstico , Pneumonia Viral/diagnóstico por imagem , Adulto , Idoso , China , Contusões/terapia , Infecções por Coronavirus/terapia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Pandemias , Pneumonia Viral/complicações , Pneumonia Viral/diagnóstico , Pneumonia Viral/terapia , Pneumonia Viral/virologia , Estudos Retrospectivos , Adulto Jovem
8.
Oncol Rep ; 2020 Apr 02.
Artigo em Inglês | MEDLINE | ID: mdl-32364243

RESUMO

Estrogen promotes non­small cell lung cancer (NSCLC) metastasis via estrogen receptor ß (ERß)­mediated invasiveness­associated matrix metalloprotease 2 (MMP2) upregulation. However, how ERß increases the aggressiveness of NSCLC cells remains unclear. Recently, MMP2 was found to be upregulated by Toll­like receptor 4 (TLR4) signaling activation and to promote NSCLC metastasis. Our present study aimed to examine the role of ERß in the activation of TLR4 signaling and in tumor progression and metastasis, and to explore the synergistic metastatic effect of a combination of ERß and TLR4 activation on human NSCLC cells in vitro and in vivo. Here, we found that ERß is associated with TLR4 in metastatic lymph nodes. Western blot analysis and immunofluorescence revealed that ERß overexpression upregulated TLR4 protein expression and activated downstream targets, myeloid differentiation primary response 88 (myd88)/nuclear factor (NF)­κB/MMP2, enhancing NSCLC cell migration and invasion in vitro. A novel ERß­TLR4 interaction in cell plasma was identified by co­immunoprecipitation and confocal immunofluorescence. The combination of estradiol and specific TLR4 agonist lipopolysaccharide (LPS) synergistically promoted metastatic behaviors in NSCLC cells. In cell culture and murine lung metastasis models, exposure to estradiol and LPS induced increased matrix degradation and accelerated invadopodia and metastasis formation in NSCLC cells compared with that in cells treated with estradiol or LPS alone. Together, we showed that estrogen promoted NSCLC metastasis via ERß by upregulating TLR4 and activating its downstream signaling axis myd88/NF­κB/MMP2. The combined targeting of ERß and TLR4 may be a novel therapeutic strategy against advanced metastatic lung cancer.

10.
Bioresour Technol ; 306: 123154, 2020 Mar 06.
Artigo em Inglês | MEDLINE | ID: mdl-32172084

RESUMO

In the present study, activated carbon was prepared from corn cob. Corn cob by potassium hydroxide activation. SEM, BET, Raman, FTIR and XPS analysis methods were used to characterize the physical and chemical properties of activated carbon. The effects of adsorbent dosage, adsorption time, pH and initial Hg(II) concentration on mercury ion removal rate were studied. The specific surface area of this material is 1054.2 m2 g-1. The Langmuir and Freundlich adsorption models were used to verify the adsorption isotherms. The adsorption isotherms were simulated well by the Langmuir model, which implied that it is a monolayer adsorption process. The kinetic data conformed to the pseudo-second-order model, which implied that the predominant process is chemisorption.

11.
Cell Death Dis ; 11(2): 129, 2020 02 18.
Artigo em Inglês | MEDLINE | ID: mdl-32071294

RESUMO

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial hyperplasia, pannus formation, and cartilage and bone destruction. Nuclear receptor subfamily 1 group D member 1 (NR1D1) functions as a transcriptional repressor and plays a vital role in inflammatory reactions. However, whether NR1D1 is involved in synovial inflammation and joint destruction during the pathogenesis of RA is unknown. In this study, we found that NR1D1 expression was increased in synovial tissues from patients with RA and decreased in RA Fibroblast-like synoviocytes (FLSs) stimulated with IL-1ß in vitro. We showed that NR1D1 activation decreased the expression of proinflammatory cytokines and matrix metalloproteinases (MMPs), while NR1D1 silencing exerted the opposite effect. Furthermore, NR1D1 activation reduced reactive oxygen species (ROS) generation and increased the production of nuclear transcription factor E2-related factor 2 (Nrf2)-associated enzymes. Mitogen-activated protein kinase (MAPK) and nuclear factor κB (NF-κB) pathways were blocked by the NR1D1 agonist SR9009 but activated by NR1D1 silencing. NR1D1 activation also inhibited M1 macrophage polarization and suppressed osteoclastogenesis and osteoclast-related genes expression. Treatment with NR1D1 agonist SR9009 in collagen-induced arthritis (CIA) mouse significantly suppressed the hyperplasia of synovial, infiltration of inflammatory cell and destruction of cartilage and bone. Our findings demonstrate an important role for NR1D1 in RA and suggest its therapeutic potential.

12.
ACS Appl Mater Interfaces ; 12(4): 4463-4472, 2020 Jan 29.
Artigo em Inglês | MEDLINE | ID: mdl-31913599

RESUMO

The oxygen reduction reaction (ORR) is an extremely important reaction in many renewable energy-related devices. The sluggish kinetics of the ORR limits the development of many fuel cells. Design and synthesis of highly efficient nonprecious electrocatalysts are of vital importance for electrochemical reduction of oxygen. Herein, we develop a graphitic carbon nitride (g-C3N4)-derived bamboo-like carbon nanotubes/carbon-wrapped Co nanoparticles (BCNT/Co) electrocatalyst by a simple high-temperature pyrolysis and acid-leaching method. The catalytic performance of the as-designed electrocatalyst toward ORR outperforms the commercial Pt/C catalyst in alkaline solution. The onset potential of nonprecious BCNT/Co-800 catalyst was 1.12 V. The half-wave potential was 0.881 V. The result was superior to that of commercial Pt/C (0.827 V vs RHE). The Co nanoparticles, bamboo-like carbon nanotubes, defects, and Co-Nx active sites all result in the remarkable ORR activity, stability, and great methanol tolerance.

13.
Nanotechnology ; 31(12): 125404, 2020 Mar 20.
Artigo em Inglês | MEDLINE | ID: mdl-31766041

RESUMO

Herein, we design a dual-template-assisted pyrolysis method to prepare ultra-small Fe3O4 nanoparticles anchored on Fe/N-doped hollow porous carbon spheres (0.010-Fe/NHPCS-800) for oxygen reduction reaction (ORR). The synthesized SiO2 nanospheres, which are selected as the hard template, contribute to forming macroporous structure. Pluronic ® F127 is employed to fabricate mesopores through high-temperature pyrolysis as a soft template. In this way, the 0.010-Fe/NHPCS-800 architecture represents an ordered hierarchically porous property with a large BET surface area (1812 m2 g-1), which can facilitate the mass transport of reactants and increase the electrochemically active area. The Fe3O4 nanoparticles wrapped by graphitic carbon layers provide more active sites, and the synergistic interaction between Fe3O4 nanoparticles and doping N has a positive effect on ORR performance. The 0.010-Fe/NHPCS-800 catalyst outperforms the most effective ORR activities among a series of Fe/NHPCS samples with onset potential of 0.95 V (versus reversible hydrogen potential) and half-wave potential of 0.81 V, which is almost the same as the commercial Pt/C (0.96 and 0.81 V, correspondingly) in 0.10 M KOH. However, both the stability and durability of 0.010-Fe/NHPCS-800 surpass those of commercial Pt/C. Given all these advantages, 0.010-Fe/NHPCS-800 is a promising candidate to take the place of Pt-based electrocatalysts for ORR in the future.

14.
ACS Sens ; 5(1): 258-264, 2020 01 24.
Artigo em Inglês | MEDLINE | ID: mdl-31876407

RESUMO

In this work, we fabricated a microbial biosensor with long-term stability, which relied on microbial activity. Activity of the microbe was commonly estimated by LIVE/DEAD assay and the propidium iodide (PI)-stained one was judged as dead. Herein, we proposed the utilization of a physiological state of microbes, which was neither live nor dead but between them. In this state, microbes represented a high PI-stained ratio but still had catalytic ability. This microbial state was obtained by forming the biofilm under the conditions of poor nutrition and low temperature. Thus, the dividing and proliferating ability of the microbes in the biofilm was weak, which was beneficial for long-term stability. This mechanism was further confirmed by the biosensors made from multifarious substrate materials, including graphene-based gel, biomass-based gel, graphite felt, and poly(vinyl chloride). This biosensor was applied to water pollution monitoring in the laboratory for 2 years and then was integrated into a multiparameter water quality monitoring station on a local lake for 2.5 years.

15.
Cells ; 8(9)2019 08 30.
Artigo em Inglês | MEDLINE | ID: mdl-31480268

RESUMO

Both 14-3-3 proteins (14-3-3s) and Rho proteins regulate cytoskeleton remodeling and cell migration, which suggests a possible interaction between the signaling pathways regulated by these two groups of proteins. Indeed, more and more emerging evidence indicates the mutual regulation of these two signaling pathways. However, all of the data regarding the interaction between Rac1 signaling pathways and 14-3-3 signaling pathways are through either the upstream regulators or downstream substrates. It is not clear if Rac1 could interact with 14-3-3s directly. It is interesting to notice that the Rac1 sequence 68RPLSYP73 is likely a 14-3-3 protein binding motif following the phosphorylation of S71 by Akt. Thus, we hypothesize that Rac1 directly interacts with 14-3-3s. We tested this hypothesis in this research. By using mutagenesis, co-immunoprecipitation (co-IP), Rac1 activity assay, immunoblotting, and indirect immunofluorescence, we demonstrate that 14-3-3s interact with Rac1. This interaction is mediated by Rac1 S71 in both phosphorylation-dependent and -independent manners, but the phosphorylation-dependent interaction is much stronger. Epidermal growth factor (EGF) strongly stimulates the phosphorylation of Rac1 S71 and the interaction between 14-3-3s and Rac1. Mutating S71 to A completely abolishes both phosphorylation-dependent and -independent interactions between 14-3-3s and Rac1. The interaction between 14-3-3s and Rac1 mostly serve to regulate the activity and subcellular localization of Rac1. Among the seven 14-3-3 isoforms, 14-3-3η, -σ, and -θ showed interactions with Rac1 in both Cos-7 and HEK 293 cells. 14-3-3γ also binds to Rac1 in HEK 293 cells, but not in Cos-7 cells. We conclude that 14-3-3s interact with Rac1. This interaction is mediated by Rac1 S71 in both phosphorylation-dependent and -independent manners. The interaction between 14-3-3 and Rac1 mostly serves to regulate the activity and subcellular localization of Rac1. Among the seven 14-3-3 isoforms, 14-3-3η, -γ, -σ, and -θ interact with Rac1.


Assuntos
Proteínas 14-3-3/metabolismo , Fator de Crescimento Epidérmico/metabolismo , Proteínas rac1 de Ligação ao GTP/metabolismo , Animais , Células COS , Chlorocebus aethiops , Ativação Enzimática , Células HEK293 , Humanos , Fosforilação , Ligação Proteica , Isoformas de Proteínas/metabolismo , Transdução de Sinais
16.
Bioresour Technol ; 293: 121962, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31449921

RESUMO

In this study, corn stalk (CS) was pretreated with furfural wastewater (FWW) for whole slurry anaerobic digestion (AD), which increased the degradability of CS components, changed the parameters in pretreatment slurry and improved the biochemical methane potential (BMP). The ultimate goal was to optimize the time and temperature for FWW pretreatment and evaluate whether FWW pretreatment is feasible from BMP and energy conversion. The results of path analysis suggested that lignocellulosic degradability (LD) was the main factor affecting methane production with the comprehensive decision of 0.7006. The highest BMP (166.34 mL/g VS) was achieved by the pretreatment at 35 °C for 6 days, which was 70.36% higher than that of control check (CK) (97.64 mL/g VS) and the optimal pretreatment condition was predicted at 40.69 °C for 6.49 days by response surface methodology (RSM). The net residual value (NRV) for the pretreatment of 35 °C and 6 days was the highest (0.6201), which was the most appropriate condition for AD in real application.


Assuntos
Águas Residuárias , Zea mays , Anaerobiose , Furaldeído , Metano
17.
Waste Manag ; 89: 303-312, 2019 Apr 15.
Artigo em Inglês | MEDLINE | ID: mdl-31079744

RESUMO

Energy utilization efficiency of heating for the operation process of biogas reactor is an important factor limiting its development and popularization. A novel mode of solar radiant heating combined with the conventional heating mode was proposed to reduce the power loss and improve the utilization cycle of heat exchanger. In present work, experimental and numerical researches about the anaerobic fermentation process under two heating modes were made to investigate the effect of temperature fluctuation on non-isothermal fermentation process under solar radiant heating. The results show that the methane production capacity of non-isothermal process under solar radiant heating reduces by up to 14% compared with the constant temperature condition in three seasons; increasing the total solid concentration of bioreactor is helpful for improving the effect of solar radiant heating; the effects of temperature fluctuation coefficient on acid and methane productions are bigger than the one on pH of slurry.


Assuntos
Reatores Biológicos , Calefação , Biocombustíveis , Metano , Luz Solar , Temperatura
18.
J Environ Manage ; 243: 411-418, 2019 Aug 01.
Artigo em Inglês | MEDLINE | ID: mdl-31103687

RESUMO

During the process of preparing furfural by straw depolymerization with dilute sulfuric acid, large amounts of high temperature sulfate-rich organic wastewater were produced. It cannot be treated directly by anaerobic digestion and converted to bioenergy due to high concentrations of sulfate. In this study, anaerobic co-digestion of sulfate containing wastewater and corn stalk was performed at thermophilic conditions to investigate the influences of total carbon (TC)/sulfate (6, 16, 35 and 110) on methane production and sulfate removal. The results showed that the highest methane production of 260.14 mL g-1 volatile solid (VS) was achieved at TC/sulfate of 35, which was significantly higher than 12.53 mL g-1 VS obtained at TC/sulfate of 6. Moreover, the results of sulfate balance analysis showed a maximum sulfate removal of 93.43% was achieved at TC/sulfate of 16, and sulfate concentration in biogas slurry was less than 0.1 g/L regardless of TC/sulfate after 28 days of co-digestion. The microbial community was analyzed using 16S rDNA sequencing technology, the results showed that methane was mainly produced by Methanoculleus and Methanosarcina, and sulfate was removed via Desulfotomaculum, and the relative abundance of methanogenic archaea (MA) and sulfate reducing bacteria (SRB) were significantly correlated with methane production and sulfate removal. It can concluded that higher methane production and sulfate removal can be obtained by anaerobic co-digestion of sulfate containing wastewater and corn stalk at properly TC/sulfate.


Assuntos
Águas Residuárias , Zea mays , Anaerobiose , Biocombustíveis , Reatores Biológicos , Carbono , Metano , Sulfatos
19.
Polymers (Basel) ; 11(3)2019 Mar 04.
Artigo em Inglês | MEDLINE | ID: mdl-30960402

RESUMO

Barium titanate (BT) and polyarylene ether nitrile (PEN) nanocomposites with enhanced dielectric properties were obtained by using carboxylatedzinc phthalocyanine (ZnPc-COOH) buffer as the plasticizer. Carboxylated zinc phthalocyanine, prepared through hydrolyzing ZnPc in NaOH solution, reacted with the hydroxyl groups on the peripheral of hydrogen peroxide treated BT (BT-OH) yielding core-shell structured BT@ZnPc. Thermogravimetric analysis (TGA), transmission electron microscopy (TEM), TEM energy dispersive spectrometer mapping, scanning electron microscopy (SEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and Fourier transform infrared (FTIR) demonstrated successful preparation of BT@ZnPc. The fabricated BT@ZnPc was incorporated into the PEN matrix through the solution casting method. Rheological measurements demonstrated that the ZnPc-COOH buffer can improve the compatibility between BT and PEN effectively. With the existence of the ZnPc-COOH buffer, the prepared BT@ZnPc/PEN nanocomposites exhibit a high dielectric constant of 5.94 and low dielectric loss (0.016 at 1000 Hz). BT@ZnPc/PEN dielectric composite films can be easily prepared, presenting great application prospects in the field of organic film capacitors.

20.
Mater Sci Eng C Mater Biol Appl ; 101: 232-242, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31029316

RESUMO

Polyetheretherketone (PEEK) has been used in orthopedic surgery for several decades. Numerous methods were invented to alter the properties of PEEK. By adding nanoparticles, fibers, etc., elastic modulus and strength of PEEK can be changed to meet certain demand. In this study, tantalum (Ta), a promising metal, was introduced to modify the properties of PEEK, in which PEEK was reinforced with different contents of tantalum nanoparticles (from 1 wt% to 9 wt%). Mechanical properties and biological functions (both in vitro and in vivo) were then investigated. The highest elastic modulus and compressive strength were observed in 3%Ta-PEEK. Cell experiments as cell adhesion, collagen secretion, biomineralization and osteogenesis related gene expression showed preferable results in 3%Ta-PEEK and 5%Ta-PEEK. Improved bone integration was shown in 3%Ta-PEEK and 5%Ta-PEEK in vivo. Above all, enhanced mechanical properties and promoted bone formation were proved for 3%Ta-PEEK and 5%Ta-PEEK compared to others groups both in vitro and in vivo, suggesting that the addition of tantalum nanoparticles modified the osseointegration ability of PEEK. This composite of tantalum and PEEK could have a clinical potential for orthopedic implants.


Assuntos
Cetonas/farmacologia , Nanopartículas/química , Osteogênese/efeitos dos fármacos , Polietilenoglicóis/farmacologia , Tantálio/farmacologia , Fosfatase Alcalina/metabolismo , Animais , Varredura Diferencial de Calorimetria , Adesão Celular/efeitos dos fármacos , Linhagem Celular , Colágeno/metabolismo , Regulação da Expressão Gênica/efeitos dos fármacos , Teste de Materiais , Camundongos , Minerais/metabolismo , Nanopartículas/toxicidade , Osseointegração/efeitos dos fármacos , Osteogênese/genética , Ratos Sprague-Dawley , Espectrometria por Raios X , Propriedades de Superfície , Termogravimetria
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