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2.
Food Chem ; 370: 131069, 2022 Feb 15.
Artigo em Inglês | MEDLINE | ID: mdl-34536780

RESUMO

Wholegrains have been promoted for human consumption due to their various health benefits. However, different wholegrains vary in nutritional composition and their beneficial impact on health. In this study, we compared the in vitro starch and protein digestibility, as well as dietary fiber content of eight different wholegrains including barley, buckwheat, coix seed, foxtail millet, oat, proso millet, quinoa, and sorghum and their porridges. We found that boiling improved starch digestibility of all grains, and protein digestibility except proso millet and sorghum. Porridges made from oats, quinoa, or buckwheat are considered healthier than others due to their lower glycemic index and glycemic load, higher digestible protein content and amino acid bioaccessibility, and higher dietary fiber content (>12%). This study could provide a comprehensive nutritional composition and digestibility of the eight types of wholegrains and their porridges. Dietary recommendations were also given for different populations based on factor analysis.


Assuntos
Dieta , Digestão , Fibras na Dieta/análise , Grão Comestível/química , Humanos , Amido
3.
Ecotoxicol Environ Saf ; 222: 112460, 2021 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-34243113

RESUMO

Fungi were microorganisms that are ubiquitous in a variety of environments. Inhalation of fungi-contaminated organic dust led to hypersensitivity pneumonitis and might eventually cause irreversible pulmonary fibrosis. Studies showed that maintaining the homeostasis of epithelial cells was vital for defending the exogenous fungi invasion. HMGB1-dependent autophagy played a critical role in maintaining cell homeostasis in multiple inflammatory diseases. However, the actual role of HMGB1-dependent autophagy in hypersensitivity pneumonitis was unclear. In our study, mice were exposed to 0.3 mg/50 µL 1,3-ß-glucan solution by intratracheal instillation to set up the lung inflammation model. To investigate the role of HMGB1-dependent autophagy in 1,3-ß-glucan induced lung inflammation, AAV-sh-HMGB1 was intratracheally injected to silence HMGB1 in the lung. Our finding suggested that silencing HMGB1 could aggravate the 1,3-ß-glucan induced lung inflammation by inhibiting the autophagy of epithelial cells. And ubiquitination of Beclin1 contributed to decreasing the interaction of Beclin1 and Bcl2, which might be a key regulatory mechanism of HMGB1 on 1,3-ß-glucan induced autophagy.


Assuntos
Proteína HMGB1 , Pneumonia , Animais , Autofagia , Proteína Beclina-1/genética , Células Epiteliais , Glucanos , Proteína HMGB1/genética , Camundongos
4.
BMC Public Health ; 21(1): 1258, 2021 06 29.
Artigo em Inglês | MEDLINE | ID: mdl-34187444

RESUMO

BACKGROUND: Occupational noise exposure was related to cardiovascular disease, of which dyslipidemia was an important inducement. This study investigated the relationship between occupational noise exposure and dyslipidemia. METHODS: Four hundred ninety-two occupational noise-exposed workers and 664 non-exposed workers were recruited to conduct environmental noise tests and personal occupational physical examinations. A lasso-logistic regression model was used to estimate the relative risk of dyslipidemia. A restricted cubic spline was used to estimate the association between noise exposure years and dyslipidemia after adjusting for potential confounding factors. RESULTS: A crude association was observed between the occupational noise exposure (75-85 dB(A)) and dyslipidemia. After adjusting for confounding factors, there was a non-linear relationship between noise exposure years and dyslipidemia (P for non-linearity =0.01). Workers exposed to 75-85 dB(A) for 11 to 24.5 years had a higher risk of dyslipidemia than non-exposed workers. CONCLUSIONS: A positive and non-linear exposure-response relationship was found in workers exposed to 75-85 dB(A) whose exposure years were between 11 and 24.5. Workers had the highest risk of dyslipidemia when exposed for 13.5 years.


Assuntos
Dislipidemias , Perda Auditiva Provocada por Ruído , Ruído Ocupacional , Doenças Profissionais , Exposição Ocupacional , Estudos Transversais , Dislipidemias/epidemiologia , Humanos , Ruído Ocupacional/efeitos adversos , Exposição Ocupacional/efeitos adversos , Prevalência
5.
Immunol Lett ; 235: 15-21, 2021 07.
Artigo em Inglês | MEDLINE | ID: mdl-33951473

RESUMO

Repeated exposure to fungi-contaminated dust can lead to multiple adverse effects on the lung, such as hypersensitivity pneumonitis, granuloma even irreversible fibrosis. 1,3-ß-glucan, a major cell wall component of fungi, is considered as its exposure biomarker. Existing studies showed that a series of Th responses were involved in 1,3-ß-glucan induced hypersensitivity pneumonitis, in which macrophages, Treg, and IL-10 producing B cells were reported to participate. The reciprocal interaction among those critical immune cells in 1,3-ß-glucan induced inflammation was not investigated yet. To clarify the regulatory mechanism of IL-10 producing B cells on Th and Treg, the current study set up a primary cell co-culture system. The anti-CD22 antibody was injected intraperitoneally to generate IL-10 producing B cells deficiency mouse model. Cells were isolated and purified from C57BL∖6 mice in different groups. Flow cytometry was used to check the phenotype of different cell subtypes. CBA assay and real-time PCR were used to examine the levels of multiple cytokines. Our results indicated that IL-10 producing B cells could modulate the 1,3-ß-glucan induced inflammatory response. The modulation of IL-10 producing B cells on Th response after 1,3-ß-glucan treatment was cell contact independent. What's more, the modulation pattern of IL-10 producing B cells might be impaired without Treg response. IL-10-producing B cells regulated 1,3-ß-glucan induced Th responses in co-ordination with Treg cells.


Assuntos
Linfócitos B/imunologia , Linfócitos B/metabolismo , Comunicação Celular/imunologia , Interleucina-10/biossíntese , Linfócitos T Reguladores/imunologia , Linfócitos T Reguladores/metabolismo , beta-Glucanas/metabolismo , Animais , Biomarcadores , Citocinas/metabolismo , Suscetibilidade a Doenças , Feminino , Imunomodulação , Imunofenotipagem , Inflamação/etiologia , Inflamação/metabolismo , Inflamação/patologia , Camundongos , Modelos Biológicos , Linfócitos T Auxiliares-Indutores/imunologia , Linfócitos T Auxiliares-Indutores/metabolismo
6.
Lab Chip ; 21(2): 355-364, 2021 01 21.
Artigo em Inglês | MEDLINE | ID: mdl-33305767

RESUMO

Mobile microrobots that maneuver in liquid environments and navigate inside the human body have drawn a great interest due to their possibility for medical uses serving as an in vivo cargo. For this system, the effective self-propelling method, which should be powered wirelessly and controllable in 3-D space, is of paramount importance. This article describes a bubble-powered swimming microdrone that can navigate in 3-D space in a controlled manner. To enable 3-D propulsion with steering capability, air bubbles of three lengths are trapped in microtubes that are embedded and three-dimensionally aligned inside the drone body using two-photon polymerization. These bubbles can generate on-demand 3-D propulsion through microstreaming when they are selectively excited at their individual resonance frequencies that depend on the bubble sizes. In order to equip the drone with highly stable maneuverability, a non-uniform mass distribution of the drone body is carefully designed to spontaneously restore the drone to the upright position from disturbances. A mathematical model of the restoration mechanism is developed to predict the restoration behavior showing a good agreement with the experimental data. The present swimming microdrone potentially lends itself to a robust 3-D maneuverable microscale mobile cargo navigating in vitro and in vivo for biomedical applications.


Assuntos
Acústica , Natação , Ar , Humanos , Modelos Teóricos
7.
Toxicol Appl Pharmacol ; 394: 114959, 2020 05 01.
Artigo em Inglês | MEDLINE | ID: mdl-32201329

RESUMO

Arsenic is a ubiquitous environmental toxicant, found in high concentrations worldwide. Although abundant research has dealt with arsenic-induced cancers, studies on mechanisms of non-malignant lung diseases have not been complete. In addition, decades of research have mostly concentrated on high-dose arsenic exposure, which has very limited use in modeling the biological effects of today's low-dose exposures. Indeed, accumulated evidence has shown that low-dose arsenic exposure (i.e. ≤100 ppb) may also alter lung homeostasis by causing host susceptibility to viral infection. However, the underlying mechanism of this alteration is unknown. In this study, we found that low-dose sodium arsenite (As (III)) repressed major airway mucins-MUC5AC and MUC5B at both mRNA and protein levels. We further demonstrated that this repression was not caused by cellular toxicity or mediated by the reduction of a common mucin-inducing pathway-EGFR. Other established mucin activators- dsRNA, IL1ß or IL17 were not able to override As (III)-induced mucin repression. Interestingly, the suppressing effect of As (III) appeared to be partially reversible, and supplementation of all trans retinoic acid (t-RA) doses dependently restored mucin gene expression. Further analyses indicated that As (III) treatment significantly reduced the protein level of retinoic acid receptors (RARα, γ and RXRα) as well as RARE promoter reporter activity. Therefore, our study fills in an important knowledge gap in the field of low-dose arsenic exposure. The interference of RA signaling, and mucin gene expression may be important pathogenic factors in low-dose arsenic induced lung toxicity.


Assuntos
Arsênio/toxicidade , Mucinas/biossíntese , Mucosa Respiratória/metabolismo , Transdução de Sinais/efeitos dos fármacos , Tretinoína , Arsenitos/toxicidade , Linhagem Celular , Sobrevivência Celular/efeitos dos fármacos , Receptores ErbB/antagonistas & inibidores , Expressão Gênica/efeitos dos fármacos , Regulação da Expressão Gênica/efeitos dos fármacos , Humanos , Mucina-5AC/antagonistas & inibidores , Mucina-5AC/genética , Mucina-5B/antagonistas & inibidores , Mucina-5B/genética , Mucosa Respiratória/efeitos dos fármacos , Compostos de Sódio/toxicidade
8.
Cells ; 9(1)2020 01 04.
Artigo em Inglês | MEDLINE | ID: mdl-31947943

RESUMO

Silicosis is an occupational lung disease characterized by persistent inflammation and irreversible fibrosis. Crystalline silica (CS) particles are mainly phagocytized by alveolar macrophages (AMs), which trigger apoptosis, inflammation, and pulmonary fibrosis. Previously, we found that autophagy-lysosomal system dysfunction in AMs was involved in CS-induced inflammation and fibrosis. Induction of autophagy and lysosomal biogenesis by transcription factor EB (TFEB) nuclear translocation can rescue fibrotic diseases. However, the role of TFEB in silicosis is unknown. In this study, we found that CS induced TFEB nuclear localization and increased TFEB expression in macrophages both in vivo and in vitro. However, TFEB overexpression or treatment with the TFEB activator trehalose (Tre) alleviated lysosomal dysfunction and enhanced autophagic flux. It also reduced apoptosis, inflammatory cytokine levels, and fibrosis. Both pharmacologically inhibition of autophagy and TFEB knockdown in macrophages significantly abolished the antiapoptotic and anti-inflammatory effects elicited by either TFEB overexpression or Tre treatment. In conclusion, these results uncover a protective role of TFEB-mediated autophagy in silicosis. Our study suggests that restoration of autophagy-lysosomal function by Tre-induced TFEB activation may be a novel strategy for the treatment of silicosis.


Assuntos
Autofagia , Fatores de Transcrição de Zíper de Leucina e Hélice-Alça-Hélix Básicos/metabolismo , Lisossomos/metabolismo , Macrófagos Alveolares/patologia , Fibrose Pulmonar/induzido quimicamente , Fibrose Pulmonar/patologia , Dióxido de Silício/efeitos adversos , Trealose/farmacologia , Animais , Apoptose/efeitos dos fármacos , Autofagia/efeitos dos fármacos , Núcleo Celular/efeitos dos fármacos , Núcleo Celular/metabolismo , Cristalização , Citocinas/metabolismo , Modelos Animais de Doenças , Inflamação/patologia , Mediadores da Inflamação/metabolismo , Lisossomos/efeitos dos fármacos , Macrófagos Alveolares/efeitos dos fármacos , Macrófagos Alveolares/metabolismo , Masculino , Camundongos Endogâmicos C57BL , Transporte Proteico/efeitos dos fármacos , Especificidade por Substrato/efeitos dos fármacos
9.
Theranostics ; 9(17): 4993-5008, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31410197

RESUMO

Silicosis is pneumoconiosis of the lung, usually resulting from prolonged exposure to crystalline silica (CS). The hallmark of silicosis is excessive extracellular matrix (ECM) deposition produced by activated fibroblasts. Recent work demonstrated that excessive ECM-forming mechanical cues play an essential role in promoting fibroblast activation and perpetuating fibrotic pathologies. However, the detailed molecular mechanism still needs to be uncovered. Methods: NIH-3T3 fibroblasts were cultured on either 1 kappa (soft) or 60 kappa (stiff) gel-coated coverslips. A series of knockdown and reverse experiments in vitro were performed to establish the signaling for mechanics-induced fibroblast activation. An experimental model of silicosis was established by one-time intratracheal instillation of CS suspension. The cluster of differentiation 44 (CD44) antibody (IM7), dihydrotanshinone I (DHI) and verteporfin (VP) were used to explore the effect of CD44-RhoA-YAP signaling blockade on mechanics-induced fibroblast activation and CS-induced pulmonary fibrosis. Results: Matrix stiffness could induce nuclear translocation of the Yes-associated protein (YAP) through CD44 in fibroblasts. This effect required RhoA activity and F-actin cytoskeleton polymerization but was independent of Hippo pathway kinases, Mst 1 and Lats 1, forming CD44-RhoA-YAP signaling pathway. Pharmacological upstream blocking by CD44 antibody or downstream blockade of YAP by DHI or VP could attenuate fibroblast migration, invasion, proliferation, and collagen deposition. Furthermore, CD44-RhoA-YAP signaling blockade could alleviate CS-induced fibrosis and improve pulmonary function in vivo. Conclusion: CD44-RhoA-YAP signaling mediates mechanics-induced fibroblast activation. Targeting this pathway could ameliorate crystalline silica-induced silicosis and provide a potential therapeutic strategy to mitigate fibrosis.


Assuntos
Proteínas Adaptadoras de Transdução de Sinal/metabolismo , Proteínas de Ciclo Celular/metabolismo , Fibroblastos/efeitos dos fármacos , Receptores de Hialuronatos/metabolismo , Transdução de Sinais , Silicose/metabolismo , Proteína rhoA de Ligação ao GTP/metabolismo , Células 3T3 , Actinas/metabolismo , Proteínas Adaptadoras de Transdução de Sinal/antagonistas & inibidores , Animais , Anticorpos/imunologia , Anticorpos/uso terapêutico , Proteínas de Ciclo Celular/antagonistas & inibidores , Movimento Celular , Proliferação de Células , Matriz Extracelular/efeitos dos fármacos , Matriz Extracelular/metabolismo , Fibroblastos/metabolismo , Fibroblastos/fisiologia , Furanos , Fator de Crescimento de Hepatócito/metabolismo , Receptores de Hialuronatos/imunologia , Masculino , Camundongos , Camundongos Endogâmicos C57BL , Fenantrenos/farmacologia , Fenantrenos/uso terapêutico , Proteínas Proto-Oncogênicas/metabolismo , Quinonas , Dióxido de Silício/toxicidade , Silicose/tratamento farmacológico , Verteporfina/farmacologia , Verteporfina/uso terapêutico
10.
ChemSusChem ; 12(10): 2195-2201, 2019 May 21.
Artigo em Inglês | MEDLINE | ID: mdl-31050182

RESUMO

The iron complex of tetradentate tris[2-(diphenylphosphino) ethyl]phosphine (PP3 ), [Fe(PP3 )(MeCN)2 ](BF4 )2 , was able to electrocatalytically reduce CO2 to formate with a Faradaic efficiency (FE) of approximately 97.3 % in acetonitrile. Upon addition of diethylamine as a cocatalyst, electrocatalytic reduction to methanol was achieved with an FE of 68.5 %, and other products were formamide and formate. A mechanistic study suggested that the [FeH(PP3 )](BF4 ) hydride complex was the active species in the electrocatalysis. Added amine as cocatalyst could react with CO2 to form carbamate, which could then be reduced to formamide and further to methanol. By contrast, free CO2 could only be reduced to formate as the end-product.

11.
Theranostics ; 9(7): 1878-1892, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31037145

RESUMO

Occupational exposure to crystalline silica (CS) particles leads to silicosis, which is characterized by chronic inflammation and abnormal tissue repair. Alveolar macrophages (AMs) play a crucial role in the process of silicosis. Previously, we demonstrated positive effect of dioscin on silicosis through modulating macrophage-elicited innate immune response. However, the concrete molecular mechanism remains to be discovered. Methods: We established experimental model of silicosis with wildtype and Atg5flox/floxDppa3Cre/+ mice and oral administrated dioscin daily to explore the effects of dioscin on macrophages and pulmonary fibrosis. AM cell line MH-S with Atg5 silence was used to explore specific function of dioscin on macrophage-derived inflammation and the underlying molecular mechanism. Results: Dioscin could promote autophagy in macrophages. Dioscin-triggered AMs autophagy limited mitochondrial reactive oxygen species (mtROS) mass stimulated by CS, reduced mitochondria-dependent apoptosis pathway activation and facilitated cell survival. Relieved oxidative stress resulted in decreased secretion of inflammatory factors and chemokines. Dioscin treatment alleviated macrophage-derived inflammation and subsequent abnormal collagen repair. All the dioscin's protective effects were diminished in Atg5flox/floxDppa3Cre/+ mice. Conclusion: Dioscin promoting autophagy leads to reduced CS-induced mitochondria-dependent apoptosis and cytokine production in AMs, which may provide concrete molecular mechanism for the therapy of silicosis.


Assuntos
Autofagia/efeitos dos fármacos , Diosgenina/análogos & derivados , Macrófagos Alveolares/efeitos dos fármacos , Pneumonia/induzido quimicamente , Pneumonia/tratamento farmacológico , Fibrose Pulmonar/tratamento farmacológico , Dióxido de Silício/farmacologia , Animais , Apoptose/efeitos dos fármacos , Linhagem Celular , Sobrevivência Celular/efeitos dos fármacos , Diosgenina/farmacologia , Feminino , Macrófagos/efeitos dos fármacos , Macrófagos/metabolismo , Macrófagos Alveolares/metabolismo , Camundongos , Camundongos Endogâmicos C57BL , Mitocôndrias/efeitos dos fármacos , Mitocôndrias/metabolismo , Estresse Oxidativo/efeitos dos fármacos , Pneumonia/metabolismo , Fibrose Pulmonar/metabolismo , Espécies Reativas de Oxigênio/metabolismo , Silicose/tratamento farmacológico , Silicose/metabolismo
12.
IEEE Trans Biomed Eng ; 66(11): 3231-3237, 2019 11.
Artigo em Inglês | MEDLINE | ID: mdl-30843793

RESUMO

OBJECTIVE: The purpose of this paper is to demonstrate the ultrasound tracking strategy for the acoustically actuated bubble-based microswimmer. METHODS: The ultrasound tracking performance is evaluated by comparing the tracking results with the camera tracking. A benchtop experiment is conducted to capture the motion of two types of microswimmers by synchronized ultrasound and camera systems. A laboratory developed tracking algorithm is utilized to estimate the trajectory for both tracking methods. RESULTS: The trajectory reconstructed from ultrasound tracking method compares well with the conventional camera tracking, exhibiting a high accuracy and robustness for three different types of moving trajectories. CONCLUSION: Ultrasound tracking is an accurate and reliable approach to track the motion of the acoustically actuated microswimmers. SIGNIFICANCE: Ultrasound imaging is a promising candidate for noninvasively tracking the motion of microswimmers inside the body in biomedical applications and may further promote the real-time control strategy for the microswimmers.


Assuntos
Acústica , Engenharia Biomédica/instrumentação , Microtecnologia/instrumentação , Ultrassonografia/métodos , Algoritmos , Sistemas de Liberação de Medicamentos , Desenho de Equipamento , Microbolhas , Movimento (Física) , Imagens de Fantasmas , Gravação em Vídeo
13.
J Diabetes Investig ; 10(1): 154-162, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-29683557

RESUMO

AIMS/INTRODUCTION: Pregnant women with gestational diabetes mellitus (GDM) are at a higher risk of adverse pregnancy outcomes. The aim of the present study was to estimate the pooled prevalence of GDM in mainland China according to International Association of Diabetes and Pregnancy Study Groups criteria. MATERIALS AND METHODS: We carried out a systematic review by searching both English and Chinese literature databases. Random effects models were used to summarize the prevalence of GDM in mainland China. Subgroup and sensitivity analyses were carried out to address heterogeneity. Publication bias was evaluated using Egger's test. RESULTS: A total of 25 papers were included in the meta-analysis, involving 79,064 Chinese participants. The total incidence of GDM in mainland China was 14.8% (95% confidence interval 12.8-16.7%). Subgroup analysis showed that the age, bodyweight and family history of diabetes mellitus could significantly increase the incidence of GDM. CONCLUSIONS: To the best of our knowledge, this systematic review is the first to estimate the pooled prevalence of GDM among women in mainland China according to International Association of Diabetes and Pregnancy Study Groups criteria. The results of our systematic review suggest a high prevalence of GDM in mainland China, indicating that this country might have the largest number of GDM patients worldwide.


Assuntos
Diabetes Gestacional/epidemiologia , China/epidemiologia , Feminino , Humanos , Gravidez , Prevalência , Fatores de Risco
14.
Front Immunol ; 9: 1848, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30250465

RESUMO

Silicosis is caused by exposure to crystalline silica (CS). We have previously shown that blocking 4-1BB signaling attenuated CS-induced inflammation and pulmonary fibrosis. However, the cells that express 4-1BB, which plays a vital role in promoting fibrosis, are still unknown. In this study, we demonstrated that the expression of 4-1BB is elevated in alveolar macrophages (AMs) in the lungs of CS-injured mice. CS exposure also markedly enhanced the expression of 4-1BB in macrophage-like, MH-S cells. In these cells, activation of the 4-1BB signaling with an agonist antibody led to upregulated secretion of pro-fibrotic mediators. Consistently, blocking 4-1BB downstream signaling or genetic deletion of 4-1BB alleviated pro-fibrotic responses in vitro, while treatment with a 4-1BB fusion protein promoted pro-fibrotic responses. In vivo experiments showed that blocking 4-1BB signaling decreased the expressions of pro-fibrotic mediators and fibrosis. These data suggest that 4-1BB signaling plays an important role in promoting AMs-mediated pro-fibrotic responses and pulmonary fibrosis. Our findings may provide a potential molecular target to reduce CS-induced fibrotic responses in occupational lung disease.


Assuntos
Macrófagos Alveolares/metabolismo , Transdução de Sinais , Silicose/etiologia , Silicose/metabolismo , Membro 9 da Superfamília de Receptores de Fatores de Necrose Tumoral/metabolismo , Animais , Citocinas/metabolismo , Modelos Animais de Doenças , Feminino , Fibrose , Macrófagos Alveolares/patologia , Camundongos , Interferência de RNA , RNA Interferente Pequeno/genética , Dióxido de Silício/efeitos adversos , Silicose/patologia , Membro 9 da Superfamília de Receptores de Fatores de Necrose Tumoral/genética
15.
Zhonghua Nan Ke Xue ; 24(4): 311-316, 2018 Apr.
Artigo em Chinês | MEDLINE | ID: mdl-30168949

RESUMO

Objective: To investigate the relationship of the levels of serum androgens with lipid metabolism in middle-aged and elderly men in Zunyi, Guizhou. METHODS: Using the stratified cluster sampling method, we conducted a questionnaire investigation and physical examinations among 437 men in Zunyi City. We divided the subjects into a middle-aged (40-64 ï¼»53.20 ± 7.41ï¼½ years, n = 269) and an elderly group (=≥65 ï¼»70.63 ± 4.66ï¼½ years, n = 168) and collected fasting elbow venous blood samples from them for measuring the levels of total testosterone (TT), sex hormone-binding globulin (SHBG), luteinizing hormone (LH), total cholesterol (TCH), triglyceride (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), calculated free testosterone (cFT), free testosterone index (FTI), and testosterone secretion index (TSI). RESULTS: Compared with the elderly group, the middle-aged males showed significantly lower SHBG, LH, HDL and LDL, and higher cFT, FTI, TSI, TG and TCH (all P < 0.05). TT and SHBG were negatively correlated with TG, TCH, HDL and LDL, while cFT was positively correlated with TCH, and so was FTI with TG, TCH with LDL, and TSI with TCH, HDL and LDL (all P < 0.05), but LH was negatively correlated with TG, TCH and LDL (all P < 0.05). Multivariate linear regression analysis showed that TT and SHBG were negatively correlated with TG, TCH, HDL and LDL, and so was LH with TCH, HDL and LDL (all P < 0.05). CONCLUSIONS: In the middle-aged and elderly men in Zunyi, low concentrations of TT, SHBG and LH were associated with the increased risk of high-TCH and -LDL dyslipidemia, low concentrations of TT and SHBG with that of high-TG dyslipidemia, while high concentrations of TT, SHBG and LH with that of low-HDL dyslipidemia.


Assuntos
Androgênios/sangue , Dislipidemias/etiologia , Metabolismo dos Lipídeos , Adulto , Idoso , China , Colesterol/sangue , Humanos , Lipoproteínas HDL/sangue , Lipoproteínas LDL/sangue , Hormônio Luteinizante , Masculino , Pessoa de Meia-Idade , Análise Multivariada , Globulina de Ligação a Hormônio Sexual , Testosterona/sangue , Triglicerídeos/sangue
16.
Open Med (Wars) ; 13: 196-202, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-29770358

RESUMO

Background Both sex hormone-binding globulin and central obesity have been found to be associated with metabolic and cardiovascular diseases. However, the direct relation between sex hormone-binding globulin and central obesity has not been demonstrated. Methodology We performed a cross-sectional study of 1166 male participants from Zunyi, Guizhou, western China, in 2013. Each participant completed a questionnaire and had a brief clinical exam with a fasting blood sample taken. All blood samples underwent standard laboratory testing for sex hormone-binding globulin. Level of serum sex hormone-binding globulin was compared by demographic characteristics, and multiple linear regression was used to evaluate the independent association of variables and sex hormone-binding globulin level. Results The mean serum level of sex hormone-binding globulin was increased in old-aged men (older than 40 years; mean 44.68±20.58 nmol/L), low diastolic blood pressure (<90mmHg; 43.76±20.50 nmol/L), waist-to-height ratio <0.5 (48.73±20.59 nmol/L), no education (52.36±22.91 nmol/L), farm occupation (43.58±20.60nmol/L), non-alcohol or former user (44.78±20.94 nmol/L) and long-term medication history (44.79±21.50 nmol/L). Factors independently associated with sex hormone binding globulin level on multiple regression were waist-to-height ratio (ß=- 11.84 [95% confidence interval -13.96,-9.72]), age(ß=12.40 [9.63,15.17]) and diastolic blood pressure (ß=-5.07 [-7.44,-2.71]). Conclusions Central obesity has an independent inverse relation with serum level of sex hormone binding globulin among western Chinese men.

17.
ChemSusChem ; 11(10): 1656-1663, 2018 May 25.
Artigo em Inglês | MEDLINE | ID: mdl-29577653

RESUMO

An imino bipyridine cobalt(II) complex was developed for the electrocatalytic reduction of CO2 to formate in acetonitrile with a faradaic efficiency of approximately 80 %. For comparison, a symmetric bis-imino pyridine complex showed lower catalytic activity because of less conjugation in the system. Cyclic voltammetry, electron paramagnetic resonance and IR spectroscopy studies provided mechanistic details and the structures of the key intermediates. DFT calculations confirmed the role of large π-conjugated groups for stabilizing key intermediates through electronic conjugation.

18.
Chronobiol Int ; 35(4): 573-577, 2018 04.
Artigo em Inglês | MEDLINE | ID: mdl-29341791

RESUMO

The objective of this study is to determine whether human body odors undergo seasonal modulation. We utilized google trends search volume from the United States of America from January 1, 2010 to June 24, 2017 for a number of predetermined body odors. Regression modeling of time series data was completed. Our primary outcome was to determine the proportion of the variability in Internet searches for each unpleasant odor (about the mean) that is explained by a seasonal model. We determined that the seasonal (sinusoidal) model provided a significantly better fit than the null model (best straight line fit) for all searches relating to human body odors (P <.0001 for each). This effect was easily visible to the naked eye in the raw time series data. Seasonality explained 88% of the variability in search volume for flatulence (i.e. R2 = 0.88), 65% of the variability in search volume for axillary odor, 60% of the variability in search volume for foot odor, and 58% of the variability in search volume for bad breath. Flatulence and bad breath tended to peak in January, foot odor in February, and Axillary odor in July. We conclude that searching by the general public for information on unpleasant body odors undergoes substantial seasonal variation, with the timing of peaks and troughs varying with the body part involved. The symptom burden of such smells may have a similar seasonal variation, as might the composition of the commensal bacterial microflora that play a role in creating them.


Assuntos
Flatulência/microbiologia , Halitose/microbiologia , Microbiota , Odorantes , Estações do Ano , Humanos , Internet , Saúde da População , Ferramenta de Busca , Fatores de Tempo
19.
Sci Total Environ ; 615: 253-261, 2018 Feb 15.
Artigo em Inglês | MEDLINE | ID: mdl-28972901

RESUMO

Di (ethylhexyl) phthalate (DEHP) is a commonly used phthalates (PAEs) compound as plasticizer and becomes a severe environmental pollutant worldwide. Studies show that DEHP, as an environmental endocrine disruptor, has potential adverse effects on human. Epidemiologic studies indicate that DEHP is positively correlated to allergic diseases. Maternal exposure to DEHP may contribute to the increasing incidence of allergic diseases in offspring. However, the role of DEHP and its detailed mechanism in allergic disease of the offspring are still unclear. The aim of our study is to investigate whether DEHP maternal exposure could aggravate the allergic responses in offspring and its mechanism. Pregnant Wistar rats were randomly divided into three groups and exposed to different doses of DEHP. Half of the offspring were challenged with OVA after birth. All the pups of each group were sacrificed at postnatal day (PND)14, PND21 and PND28. The number of inflammatory cells in bronchoalveolar lavage was counted, lung pathological changes were observed, Th2 type cytokines expressions were checked, and the expression of TSLP signaling pathway were examined. Our results showed that maternal exposure to DEHP during pregnancy and lactation aggravated the eosinophils accumulation and the pathological inflammatory changes in pups' lung after OVA challenge. And maternal exposure to DEHP during pregnancy and lactation also elevated the levels of typical Th2 cytokines in OVA-challenged rats. What's more, maternal exposure to DEHP during pregnancy and lactation increased the levels of TSLP, TSLPR and IL-7R in the offspring after OVA challenge. Our study suggested that DEHP maternal exposure could aggravate the OVA-induced asthmatic responses in offspring. And this adjuvant effect of DEHP was related with the TSLP/TSLPR/IL-7R and its downstream signal pathways.


Assuntos
Asma/induzido quimicamente , Dietilexilftalato/efeitos adversos , Exposição Materna/efeitos adversos , Plastificantes/efeitos adversos , Animais , Asma/patologia , Citocinas/imunologia , Feminino , Inflamação/patologia , Ovalbumina , Gravidez , Efeitos Tardios da Exposição Pré-Natal , Ratos , Ratos Wistar , Receptores de Interleucina-7/imunologia , Serina Endopeptidases/imunologia
20.
Appl Microbiol Biotechnol ; 102(1): 509, 2018 01.
Artigo em Inglês | MEDLINE | ID: mdl-29164290

RESUMO

The published online version contains editing mistake in Table 2. See below for the corrected Table.

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