Your browser doesn't support javascript.
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 90
Filtrar
1.
J Acoust Soc Am ; 146(2): 1290, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31472535

RESUMO

A borehole multipole acoustic field in a pre-stressed formation is investigated. The pre-stressed formation is modeled as a transversely isotropic medium induced by uniaxial stress. The formation is assumed to be isotropic in absence of any static stress and then becomes anisotropic due to the applied stress parallel to the borehole axis. The approximate equivalent elastic constants of the stress-induced anisotropic medium are derived from the theory of acoustoelasticity. The nonlinear static stress-strain relation is used for both small and large static deformations. This problem can be solved analytically because of uniformity of deformation induced by static stress applied parallel to the borehole axis. The stress effects on the velocity of guided waves and amplitude of waveforms excited by monopole, dipole, and quadrupole sources are investigated. Numerical results show that the velocities of guided waves increase with uniaxial stress. The uniaxial stress affects both amplitude and arrival time of the acoustic waves in the borehole. The integral amplitude of full waveforms varies almost in a parabolic manner with the increasing stress level and thus shows sensitivity to the uniaxial stress. This result may be helpful for remote stress measurements in boreholes.

2.
Environ Sci Technol ; 53(15): 8672-8681, 2019 Aug 06.
Artigo em Inglês | MEDLINE | ID: mdl-31290654

RESUMO

Thermally activated persulfate is a promising oxidant for in situ remediation of perfluorooctanoic acid (PFOA), yet a comprehensive understanding of the degradation mechanism is still lacking. In this study, we used density functional theory (DFT) calculations and experimental data to map entire reaction pathways for the degradation of PFOA by persulfate, with specific considerations on the influence of pH. The DFT results showed that the rate-limiting step was the first electron abstraction from PFOA, yet the generation of SO4•- from the decomposition of persulfate contributed a large part of the free energy of activation (ΔG‡) for the overall reaction. The subsequent steps did not contribute to the ΔG‡. For the electron abstraction from PFOA, we investigated reactions using protonated and deprotonated species of PFOA and SO4•- and showed that the reaction of anionic PFOA with HSO4• was most favorable with a ΔG‡ of 7.2 kJ/mol. This explains why low pH (<3.5) is a sine qua non condition for the degradation of PFOA by persulfate. The overall ΔG‡ derived theoretically based on the pathway involved HSO4• was consistent with the ΔG‡ determined experimentally. This study provides valuable insight into remediation strategies that include persulfate as an oxidizing agent for perfluoroalkyl carboxylic acids.

3.
Neurosci Lett ; 707: 134312, 2019 08 10.
Artigo em Inglês | MEDLINE | ID: mdl-31163225

RESUMO

This study aimed to explore the relationship between autophagy and synaptic plasticity in the pathogenesis of vascular dementia (VD). The autophagy inhibitor 3-methyladenine (3-MA) and the autophagy agonist rapamycin (Rap) were injected into the lateral ventricles of rats, and a rat VD model was established using a modified four-vessel occlusion method. The expression of LC3-II, synaptophysin (Syn), and postsynaptic density protein 95 (PSD-95) in the CA1 area of the rat hippocampus were detected using western blotting. Decreased Syn and PSD-95 expression in the VD group was accompanied by an increased LC3-II/LC3-I ratio. The expression of Syn and PSD-95 increased after 3-MA application, but decreased following Rap application. The LC3-II/LC3-I ratio was negatively correlated with Syn and PSD-95 expression. These findings suggest that autophagy may regulate synaptic plasticity in the hippocampus in a VD model of rats. Inhibition of autophagy is beneficial to the remodeling of synapses in the hippocampal CA1 area of the VD rat model, and this may provide a theoretical basis for the treatment and prevention of VD.

4.
J Colloid Interface Sci ; 552: 719-727, 2019 Sep 15.
Artigo em Inglês | MEDLINE | ID: mdl-31176918

RESUMO

Membrane surface functionalization based on mussel-inspired polydopamine (PDA) deposition for enhancing antifouling ability has attracted considerable attention. However, high cost of dopamine (DA) and long-time of reaction during self-polymerization of DA in aqueous solution remain the major problems impeding its practical application. This study provided a first report on a low-cost and facile membrane modification approach based on inkjet printing of DA and sodium periodate (SP) to rapidly deposit PDA on polypropylene (PP) membrane. Compared with the pristine PP membrane and DA printed PP membrane, the PDA-SP coated PP membrane demonstrated superior hydrophilicity (67.2°), high pure water permeability (2156.8 L·m-2·h-1) and antifouling property, due to the improved oxidation degree of PDA. Moreover, the modified membrane possesses good chemical stability in aqueous solution over the wide range of pH 2-9. The inkjet printing integrated oxidant-induced mussel-inspired modification proposed in this study is substrate-independent, and can be applied to various geometries and materials, showing broad application prospects in membrane fabrication.

5.
Sci Total Environ ; 683: 480-488, 2019 Sep 15.
Artigo em Inglês | MEDLINE | ID: mdl-31141749

RESUMO

Betaine-based polyfluoroalkyl surfactants are major perfluoroalkyl and polyfluoroalkyl surfactants (PFASs) found in many aqueous film-forming foams (AFFF) impacted sites, while the transport behavior (i.e., mobility and adsorption) of PFAS-based betaines in groundwater and natural geosorbents interfaces remains unclear. To fill the knowledge gap, partitioning between of 15 AFFF-relevant PFASs, including 3 fluorotelomer sulfonates (FTSAs) and 3 polyfluoroalkyl betaines, and a model soil organic matter (SOM) were systematically assessed using a modified column chromatography approach. Results show that the retention of FTSAs (perfluoroalkyl chain-length of 4, 6, and 8) to SOM are similar to that of corresponding legacy perfluoroalkyl sulfonic acids (PFSAs) with the same chain length; FTSAs also respond to changes in solution chemistry similarly as PFSAs. At a solution pH of 5.9, based on the equilibrium speciation of the betaine-PFASs together with the experimental observations, the predominance of the neutral species over zwitterions gives rise to the relatively higher retention of polyfluoroalkyl betaines than perfluoroalkyl carboxylic acids (PFCAs) of equivalent chain-length. Sorption edges (minimal and maximal logKoc values over a defined pH range) determined for three polyfluoroalkyl betaines are: 1.90-3.81 for perfluorooctaneamide betaine (PFOAB), 2.03-2.65 for perfluoroctane sulfonamide betaine (PFOSB), and < 3.04 for 6:2 fluorotelomer sulfonamide betaine (6:2 FTAB). Moreover, the increase in pH reduces the sorption of all PFASs to SOM. Increasing calcium ion (concentration ranges from 0.5 to 50 mM) has enhanced the sorption of anionic PFASs to SOM but decreased the sorption of the polyfluoroalkyl betaines. These findings are expected to improve the ability to anticipate and predict the possible subsurface locations (i.e., predominantly in groundwater or sorbed to soil) of both novel and legacy PFASs.

6.
Pathol Res Pract ; 215(6): 152428, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-31064721

RESUMO

HCC (hepatocellular carcinoma) is a highly aggressive malignancy that cause a mass of deaths world widely. We chose gene expression datasets of GSE27635 and GSE28248 from GEO database to find out key genes and their interaction network during the progression and metastasis of HCC. GEO2R online tool was used to screen differentially expressed genes (DEGs) between tumor and peri-tumor tissues based on these two datasets. The identified differentially expressed genes were prepared for further analysis such as GO function, KEGG pathway, PPI network analysis using Database for Annotation, Visualization and Integrated Discovery (DAVID) and Retrieval of Interacting Genes (STRING). Two modules were constructed by MOCDE plugin in Cytoscape and 21 genes were selected as hub genes during this analysis. The expression heatmap and GO function of hub genes were performed using R pheatmap package and BiNGO plugin in Cytoscape respectively. Six hub genes including CDC25 A, CDK1, HMMR, MYBL2, TOP2A were recollected for survival analysis and their expression was validated using Kaplan Meier-plotter and GEPIA website. We also investigated the DEGs between metastasis and non-metastasis tissues and two genes (NQO1 and PTHLH) are highly associated with the metastasis in HCC. Further verification using woundhealing and transwell assay confirmed their ability to mediate cell migration and invasion. In summary, our results obtained by bioinformatic analysis and experimental validation revealed the dominant genes and their interaction networks that are associated with the progression and metastasis of HCC and might serve as potential targets for HCC therapy and diagnosis.

7.
Jpn J Clin Oncol ; 49(7): 646-655, 2019 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-30968933

RESUMO

BACKGROUND AND AIM: The impact of transarterial chemoembolization (TACE) and preventive antiviral therapy on the occurrence of hepatitis B virus (HBV) reactivation and subsequent hepatitis remains controversial. This meta-analysis aimed to evaluate the effect of TACE and preventive antiviral therapy on the risk of HBV reactivation and subsequent hepatitis. Meanwhile, we explored the role of HBeAg status in HBV reactivation after TACE. METHODS: We performed this meta-analysis with 11 included studies to assess the effect of TACE and preventive antiviral therapy on predicting clinical outcomes in HBV-related hepatocellular carcinoma (HCC). The pooled odds ratios (OR) were calculated using a random or fixed effects model. PUBMED, MEDLINE, EMBASE and the Cochrane Central Register of Controlled were searched for the included articles (from 2000 to December 2017). RESULTS: Our results showed that TACE significantly increased the risk of HBV reactivation (OR: 3.70; 95% CI 1.45-9.42; P < 0.01) and subsequent hepatitis (OR: 4.30; 95% CI 2.28-8.13; P < 0.01) in HCC patients. There was no significant difference in HBV reactivation after TACE between HBeAg positive and negative patients (OR: 1.28; 95% CI 0.31-5.34; P = 0.73). Preventive antiviral therapy could statistically reduce the rate of HBV reactivation (OR: 0.08; 95% CI 0.02-0.32; P < 0.01) and hepatitis (OR: 0.22; 95% CI 0.06-0.80; P = 0.02) in those with TACE treatment. CONCLUSIONS: The present study suggested that TACE was associated with a higher possibility of HBV reactivation and subsequent hepatitis. Preventive antiviral therapy is significantly in favor of a protective effect.


Assuntos
Antivirais/farmacologia , Carcinoma Hepatocelular/terapia , Carcinoma Hepatocelular/virologia , Quimioembolização Terapêutica , Vírus da Hepatite B/efeitos dos fármacos , Hepatite B/prevenção & controle , Neoplasias Hepáticas/terapia , Ativação Viral/efeitos dos fármacos , Adulto , Idoso , Feminino , Seguimentos , Humanos , Neoplasias Hepáticas/virologia , Masculino , Pessoa de Meia-Idade , Prognóstico , Viés de Publicação , Fatores de Risco
8.
Pathol Res Pract ; 215(6): 152386, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-30935762

RESUMO

AIM: To elucidate whether the interaction between Anxa2 and Stat3 could promote the progression of hepatocellular carcinoma (HCC) and that high co-expression of Anxa2 and Stat3 could predict poor prognosis in HCC patients. METHODS: We investigated Anxa2 and Stat3 expression using Western blot analysis in 4 HCC and adjacent nontumor tissues and using immunohistochemistry in 100 patients' paraffin sections. Then we assessed the expression of Stat3, Anxa2 and co-expression of Stat3 and Anxa2 with relevant clinical pathological parameters and their prognostic value in HCC patients. The recurrence and overall survival rates were estimated using the Kaplan-Meier method and compared with the log-rank test. The prognostic analysis was carried out with univariate and multivariate Cox regressions models. RESULTS: The incidence of high Stat3 expression in HCC tissues (35%) was significantly higher than that in non-HCC tissues (8%) (P < 0.001). The same result was observed in Anxa2 (P < 0.001). Also, the overexpression of Stat3 or Anxa2 showed a significant relationship with the recurrence of the 100 HCC patients (P = 0.012; P = 0.003). Additionally, tumor size >3 cm in diameter, multiple tumor number, and the presence of microvascular tumor thrombus were also significantly associated with recurrence in 100 patients. Then, all enrolled patients were divided into four groups according to IHC score of Stat3 and Anxa2, and the results indicated a significant difference in recurrence time between the subgroups (P < 0.001). What's more, co-highexpression of Stat3 and Anxa2 was related to the presence of microvascular tumor thrombus (P = 0.003) and poor tumor differentiation (P < 0.001), but not relevant with other clinical features (All P > 0.05). CONCLUSION: The expression of Stat3, Anxa2, or co-high-expression of the two proteins was associated with HCC recurrence and survival.

9.
Genet Test Mol Biomarkers ; 23(3): 215-222, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30793953

RESUMO

Pancreatic cancer (PC) is a digestive system tumor that is highly malignant, with an increasing incidence rate, poor prognosis, and a low 5-year survival rate. The overwhelming majority of patients with PC are in an advanced stage at the time of diagnosis and have lost the opportunity for radical surgery. The efficacy of radiotherapy and chemotherapy for PC is very poor. Therefore, it is of great significance to explore the mechanisms of PC development and new therapeutic targets. Exosomes are extracellular vesicles that mediate the exchange of substances and information between cells. In recent years, exosomes have been shown to play a key role in the development and progression of PC and might be useful for both its diagnosis and treatment. This article reviews the composition and function of exosomes and their roles in the development, diagnosis, and treatment of PC.


Assuntos
Exossomos/fisiologia , Neoplasias Pancreáticas/diagnóstico , Neoplasias Pancreáticas/terapia , Biomarcadores Tumorais/genética , Progressão da Doença , Humanos
10.
Talanta ; 195: 533-542, 2019 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-30625579

RESUMO

The total oxidizable precursor (TOP) assay can be useful for integrating precursors to perfluoroalkyl acids (pre-PFAAs) into the assessment of sites contaminated by per- and polyfluoroalkyl substances (PFAS). Current research gaps include risks of instrumental matrix effects due to the complexity of post-oxidation extracts, potential reproducibility issues during TOP itself, and limited information for zwitterionic and cationic pre-PFAAs. We first investigated a suitable method for the analysis of groundwater samples, using liquid chromatography high-resolution mass spectrometry (UHPLC-HRMS). Initial sample pre-treatment through filtration could affect the dissolved PFAS concentrations and was therefore avoided. Amending the postoxidation samples with methanol allowed for improved precision and low instrumental matrix effects. We also documented the oxidation yields of 23 anionic, neutral, zwitterionic, and cationic precursor compounds of PFAAs. These precursor compounds were amenable to TOP conversion. The total oxidative yield of 6:2 fluorotelomer sulfonamidoalkyl betaine (6:2 FTAB), for instance, was 80 mol%, with C3-C5 PFCAs as major oxidation products (minor: C6-C7 PFCAs). The method was applied to determine a wide range of PFAS (n = 41) without oxidation as well as ΔPFCA via persulfate oxidation in AFFF-impacted groundwater samples from fire-equipment testing sites in Ontario and Newfoundland, Canada. Summed PFAS concentrations as high as 5 mg L-1 were reported before oxidation, and post-oxidation increases of PFCAs up to + 2300% were observed. A significant contribution of increases in individual PFCAs was attributed to precursors such as 6:2 FTAB, fluorotelomer sulfonates (6:2 FtS, 8:2 FtS), perfluorooctane sulfonamidoalkyl amine (PFOSAm), and perfluorohexane sulfonamide (FHxSA) at the active firefighting training site.

11.
Sci Total Environ ; 647: 690-698, 2019 Jan 10.
Artigo em Inglês | MEDLINE | ID: mdl-30092525

RESUMO

6:2 fluorotelomer sulfonamidoalkyl betaine (6:2 FTAB) is a major component of aqueous film-forming foams (AFFFs) used for firefighting and is frequently detected, along with one of its suspected transformation products, 6:2 fluorotelomer sulfonate (6:2 FTSA), in terrestrial and aquatic ecosystems impacted by AFFF usage. Biochemical processes underlying bacterial biodegradation of these compounds remain poorly understood due to a lack of pure culture studies. Here, we characterized the water-soluble and volatile breakdown products of 6:2 FTSA and 6:2 FTAB produced using Gordonia sp. strain NB4-1Y cultures over seven days under sulfur-limited conditions. After 168 h, 99.9% of 60 µM 6:2 FTSA was degraded into ten major breakdown products, with a mol% recovery of 88.2, while 70.4% of 60 µM 6:2 FTAB was degraded into ten major breakdown products, with a mol% recovery of 84.7. NB4-1Y uses two pathways for 6:2 FTSA metabolism, with 55 mol% of breakdown products assigned to a major pathway and <1.0 mol% assigned to a minor pathway. This work indicates that rapid transformation of 6:2 FTSA and 6:2 FTAB can be achieved under controlled conditions and improves the bacterial metabolism of these compounds.


Assuntos
Betaína/metabolismo , Fluorcarbonetos/metabolismo , Gordonia (Bactéria)/metabolismo , Enxofre/metabolismo , Poluentes Químicos da Água/metabolismo , Alcanossulfonatos , Biodegradação Ambiental
12.
Cancer Sci ; 2018 Nov 16.
Artigo em Inglês | MEDLINE | ID: mdl-30444001

RESUMO

Hepatocellular carcinoma (HCC) is a common and aggressive malignant tumor with poorly defined molecular mechanism. Cyclin-dependent kinase 2 (CDK2) and Septin2 (SEPT2) are two known oncogenic molecules but the mechanism of functional interactions remains unclear. Here, we interestingly found that CDK2 and SEPT2 show very similar dynamic expression during cell cycle. Both CDK2 and SEPT2 show highest protein level in G2/M phase, resulting in the fact that CDK2 interacts with SEPT2 and stabilizes SEPT2 in HCCs. In a panel of eight pairs of fresh HCC tissues and corresponding adjacent tissues, both WB and IHC assays demonstrate that CDK2 expression is highly correlated with SEPT2. HCCs with high expression of both CDK2 and SEPT2 are more likely to relapse. This observation is further demonstrated by a large panel of 100 HCC patients. In such large panel, high expression of both CDK2 and SEPT2 significantly correlates with tumor differentiation and microvascular invasion, which is an independent prognostic factor in HCC patients. In summary, our results reveal a cooperative function between CDK2 and SEPT2. HCCs with high expression of CDK2 and SEPT2 might be more aggressive and response poorly to current therapy. This article is protected by copyright. All rights reserved.

13.
Mol Biol Rep ; 2018 Oct 10.
Artigo em Inglês | MEDLINE | ID: mdl-30306507

RESUMO

Psychological stress has been recognized as a well-documented risk factor associated with ß2-adrenergic receptor (ß2-AR) in the development of pancreatic cancer. Aldo-keto reductase 1 member B1 (AKR1B1) is a potential interacting partner of ß2-AR, but the effect of their interaction on pancreatic cancer cells is not known at present. We found a positive correlation between AKR1B1 and ß2-AR expression in pancreatic cancer tissue samples, and co-localization of these proteins in the human pancreatic cancer BXPC-3 cell line. Compared to the controls, the CFPAC-1 and PANC-1 pancreatic cancer cells overexpressing ß2-AR and AKR1B1 respectively showed significantly higher proliferation rates, which is attributed to higher proportion of cells in the S phase and decreased percentage of early apoptotic cells. Furthermore, overexpression of ß2-AR led to a significant increase in the expression of AKR1B1 and phosphorylated extracellular signal-regulated kinase (p-ERK1/2). Overexpression of AKR1B1 significantly decreased ß2-AR levels and increased that of p-ERK1/2. Taken together, ß2-AR directly interacted with and up-regulated AKR1B1 in pancreatic cancer cells, and promoted their proliferation and inhibited apoptosis via the ERK1/2 pathway. Our findings also highlight the ß2-AR-AKR1B1 axis as a potential therapeutic target for pancreatic cancer.

14.
Anal Chim Acta ; 1034: 74-84, 2018 Nov 30.
Artigo em Inglês | MEDLINE | ID: mdl-30193642

RESUMO

The comprehensive analysis of aqueous film forming foam (AFFF) formulations has led in recent years to the discovery of novel classes of perfluoroalkyl and polyfluoroalkyl substances (PFASs). Whether the pre-existing analytical methods for historically monitored PFASs, including perfluorooctane sulfonate (PFOS), could be transferable to a large breadth of newly identified PFASs remains, however, an open question. Data from various lines of evidence indicate that current extraction procedures previously validated with anionic and neutral PFASs may seriously underperform for many cationic and zwitterionic PFASs. The extraction efficiency and instrumental response could be strongly matrix-dependent, which may preclude a robust analysis. The present study sought to investigate a suitable sample preparation procedure for the analysis of anionic, cationic, and zwitterionic PFASs in soil samples. In total, 86 PFASs, representing 24 chemical classes previously discovered in AFFF formulations or at AFFF-impacted sites, were evaluated. The merits and limitations of various extraction media were examined using an AFFF-impacted field-weathered loam soil, as well as a background loam soil amended with AFFFs in-house. Methanol with hydrochloric acid provided excellent recoveries for most cationic and zwitterionic PFASs, including fluorotelomer sulfonamidoalkyl betaines (e.g., 6:2 FTAB) and fluorotelomer betaines (e.g., 9:1:2 FTB), yet performed less satisfactorily for certain anionic PFASs, and may also cause conversion of some PFASs. Sequential extractions using methanol with ammonium acetate exhibited limited matrix effects and suitable recoveries of PFASs from soils of diverse textural classes and organic matter content. The newly-developed extraction method presented the best option for future in-depth characterization of PFASs at AFFF-impacted sites.

15.
Environ Health Perspect ; 126(8): 84502, 2018 08.
Artigo em Inglês | MEDLINE | ID: mdl-30235423

RESUMO

Per- and polyfluoroalkyl substances (PFASs) are man-made chemicals that contain at least one perfluoroalkyl moiety, [Formula: see text]. To date, over 4,000 unique PFASs have been used in technical applications and consumer products, and some of them have been detected globally in human and wildlife biomonitoring studies. Because of their extraordinary persistence, human and environmental exposure to PFASs will be a long-term source of concern. Some PFASs such as perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS) have been investigated extensively and thus regulated, but for many other PFASs, knowledge about their current uses and hazards is still very limited or missing entirely. To address this problem and prepare an action plan for the assessment and management of PFASs in the coming years, a group of more than 50 international scientists and regulators held a two-day workshop in November, 2017. The group identified both the respective needs of and common goals shared by the scientific and the policy communities, made recommendations for cooperative actions, and outlined how the science-policy interface regarding PFASs can be strengthened using new approaches for assessing and managing highly persistent chemicals such as PFASs. https://doi.org/10.1289/EHP4158.

16.
Biomed Res Int ; 2018: 3634563, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30148165

RESUMO

Exosomes are discrete populations of small (40-200 nm in diameter) membranous vesicles that are released into the extracellular space by most cell types, eventually accumulating in the circulation. As molecular messengers, exosomes exert a broad array of vital physiologic functions by transporting information between different cell types. Because of these functional properties, they may have potential as biomarker sources for prognostic and diagnostic disease. Recent research has found that exosomes have potential to be utilized as drug delivery agents for therapeutic targets. However, basic researches on exosomes and researches on their therapeutic potential both require the existence of effective and rapid methods for their separation from human samples. In the current absence of a standardized method, there are several methods available for the separation of exosomes, but very few studies have previously compared the efficiency and suitability of these different methods. This review summarized and compared the available traditional and novel methods for the extraction of exosomes from human samples and considered their advantages and disadvantages for use in clinical laboratories and point-of-care settings.

17.
Pathol Res Pract ; 214(9): 1356-1361, 2018 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-30049513

RESUMO

Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death worldwide. Therefore, the study of the precise molecular mechanism underlying hepatocarcinogenesis has profound significance. In this study, we found that the expression of ARP3 was significantly up-regulated in HCC tissues and cell lines. Studies in liver cancer specimens showed that the expression of ARP3 is closely related to the pathological grade, distant metastasis and vascular invasion of HCC. According to the results of multivariate analysis, ARP3 is an independent prognostic factor for HCC patients. In vitro, knockdown of ARP3 expression significantly inhibited the invasion and migration of HCC cells and altered the expression of EMT markers. Based on the above conclusions, we conclude that ARP3 may be a potential prognostic indicator and therapeutic target for HCC patients.


Assuntos
Proteína 3 Relacionada a Actina/biossíntese , Biomarcadores Tumorais/análise , Carcinoma Hepatocelular/patologia , Neoplasias Hepáticas/patologia , Proteína 3 Relacionada a Actina/análise , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Invasividade Neoplásica/patologia , Prognóstico
18.
Environ Sci Technol ; 52(11): 6300-6308, 2018 Jun 05.
Artigo em Inglês | MEDLINE | ID: mdl-29706067

RESUMO

The sorption of perfluoroalkyl acids (PFAAs), particularly perfluorooctanesulfonic acid (PFOS), to freshly synthesized nanoscale zerovalent iron (nZVI) and aged (oxidized) and sulfidated nZVI, was investigated under anaerobic conditions. The sorption of PFAAs to nZVI was 2-4 orders of magnitude higher than what has been reported for sediments, soils, and iron oxides. The hydrophobicity of the perfluorocarbon chain dominated the sorption, although FTIR spectra indicated specific interactions between sulfonate and carboxylate head groups and nZVI. The contributions from electrostatic interactions depended on the surface charge and pH. Humic acids influenced sorption only at concentrations above 50 mg/L. nZVI aged in deoxygenated water up to 95 days showed similar sorption isotherms for PFOS to fresh nZVI, because Fe(OH)2 was the predominant phase on the nZVI surface independent of aging time. Sulfidation of nZVI reduced sorption of PFOS by 1 log unit owing to the FeS deposited, but the sorption affinity was restored after aging because of formation of Fe(OH)2. Oxidation of nZVI by water and dissolved oxygen also resulted in similar sorption of PFOS as fresh nZVI at environmentally relevant concentrations. The results suggest that injection of nZVI could reduce PFAA concentrations in groundwater despite changes to its surface chemistry with aging.

19.
Sci Total Environ ; 616-617: 1089-1100, 2018 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-29100694

RESUMO

In the last decade or so, concerns have arisen with respect to the widespread occurrence of perfluoroalkyl acids (PFAAs) in the environment, food, drinking water, and humans. In this study, the occurrence and levels of a large range of perfluoroalkyl and polyfluoroalkyl substances (PFASs) were investigated in drinking water (bottled and tap water samples) from various locations around the world. Automated off-line solid phase extraction followed by ultra-high-performance liquid chromatography coupled to high-resolution mass spectrometry was used to analyze PFASs of various chain lengths and functional groups. In total, 29 target and 104 suspect-target PFASs were screened in drinking water samples (n=97) from Canada and other countries (Burkina Faso, Chile, Ivory Coast, France, Japan, Mexico, Norway, and the USA) in 2015-2016. Out of the 29 PFASs quantitatively analyzed, perfluorocarboxylates (PFCAs: C4/14), perfluoroalkane sulfonates (PFSAs: C4, C6, C8), and perfluoroalkyl acid precursors (e.g., 5:3 fluorotelomer carboxylate (5:3 FTCA)) were recurrently detected in drinking water samples (concentration range:

Assuntos
Água Potável/química , Monitoramento Ambiental , Fluorcarbonetos/análise , Poluentes Químicos da Água/análise , Poluição Química da Água/estatística & dados numéricos , Abastecimento de Água/estatística & dados numéricos , Alcanossulfonatos/análise , Ácidos Alcanossulfônicos/análise
20.
Zhongguo Fei Ai Za Zhi ; 20(9): 652-656, 2017 Sep 20.
Artigo em Chinês | MEDLINE | ID: mdl-28935021

RESUMO

Lung cancer is a common malignant tumor in clinic. Morbidity and mortality are the first place in cancer, which seriously threaten the health of human beings. Due to the lack of effective and specific screening methods, most patients were found already at an advanced stage, and often combined with bone, brain, liver, adrenal and other parts of the metastasis. Symptoms of patient resulted from the primary tumor, metastatic spread, or paraneoplastic syndrome commonly cause the medical attention. For the syndrome related to the distant metastatic spread as the first manifestation, diagnosis would be a challenge. Retinal metastasis is very rare as the first symptom of squamous cell carcinoma of the lung. This paper reviewed a case, in which a patient developed the retinal metastasis as the inital presentation. After systemic evaluation, our patient was managed in multidisciplinary treatments, including surgery and chemotherapy. Now, the patient has a good short-term prognosis and is still in fellow-up condition. Later, we summarized the characteristics of the diagnosis and treatment of this case and provided experience for clinicians. At the same time, reviewing the relevant literature on tumor metastasis provides a window for our understanding of the rare manifestations of lung cancer.


Assuntos
Carcinoma Pulmonar de Células não Pequenas/complicações , Neoplasias Pulmonares/complicações , Neoplasias da Retina/secundário , Carcinoma Pulmonar de Células não Pequenas/tratamento farmacológico , Carcinoma Pulmonar de Células não Pequenas/cirurgia , Feminino , Humanos , Neoplasias Pulmonares/tratamento farmacológico , Neoplasias Pulmonares/cirurgia , Pessoa de Meia-Idade , Neoplasias da Retina/tratamento farmacológico , Neoplasias da Retina/cirurgia , Tomografia de Coerência Óptica
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA