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1.
PLoS One ; 15(7): e0228302, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32628668

RESUMO

Programmed death ligand 1 (PD-L1) has been recently shown to be a major obstacle to antiviral immunity by binding to its receptor programmed death 1 (PD-1) on specific IFN-γ producing T cells in chronic hepatitis B. Currently, IFN-α is widely used to treat hepatitis B virus (HBV) infection, but its antiviral effect vary greatly and the mechanism is not totally clear. We found that IFN-α/γ induced a marked increase of PD-L1 expression in hepatocytes. Signal and activators of transcription (Stat1) was then identified as a major transcription factor involved in IFN-α/γ-mediated PD-L1 elevation both in vitro and in mice. Blockage of the PD-L1/PD-1 interaction by a specific mAb greatly enhanced HBV-specific T cell activity by the gp96 adjuvanted therapeutic vaccine, and promoted HBV clearance in HBV transgenic mice. Our results demonstrate the IFN-α/γ-Stat1-PD-L1 axis plays an important role in mediating T cell hyporesponsiveness and inactivating liver-infiltrating T cells in the hepatic microenvironment. These data raise further potential interest in enhancing the anti-HBV efficacy of IFN-α and therapeutic vaccines.

2.
Chem Commun (Camb) ; 2020 Jul 03.
Artigo em Inglês | MEDLINE | ID: mdl-32618290

RESUMO

Herein, we develop a novel tripartite DNA probe to transport phosphorothioated substrate hairpins and an aptamer for the intramolecular CHA circuit, which achieves detection of a low amount of specific mRNA in living cells and mice. Our study provides an improved strategy to promote in vivo fluorescence imaging applications in early-stage clinical diagnosis.

3.
Cell Res ; 2020 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-32612200

RESUMO

Autophagy is a conserved process that delivers cytosolic substances to the lysosome for degradation, but its direct role in the regulation of antiviral innate immunity remains poorly understood. Here, through high-throughput screening, we discovered that CCDC50 functions as a previously unknown autophagy receptor that negatively regulates the type I interferon (IFN) signaling pathway initiated by RIG-I-like receptors (RLRs), the sensors for RNA viruses. The expression of CCDC50 is enhanced by viral infection, and CCDC50 specifically recognizes K63-polyubiquitinated RLRs, thus delivering the activated RIG-I/MDA5 for autophagic degradation. The association of CCDC50 with phagophore membrane protein LC3 is confirmed by crystal structure analysis. In contrast to other known autophagic cargo receptors that associate with either the LIR-docking site (LDS) or the UIM-docking site (UDS) of LC3, CCDC50 can bind to both LDS and UDS, representing a new type of cargo receptor. In mouse models with RNA virus infection, CCDC50 deficiency reduces the autophagic degradation of RIG-I/MDA5 and promotes type I IFN responses, resulting in enhanced viral resistance and improved survival rates. These results reveal a new link between autophagy and antiviral innate immune responses and provide additional insights into the regulatory mechanisms of RLR-mediated antiviral signaling.

4.
Scand J Gastroenterol ; : 1-8, 2020 Jun 22.
Artigo em Inglês | MEDLINE | ID: mdl-32568566

RESUMO

Background and aim: Accurate differentiation of patients with ulcerative colitis (UC) or Crohn's disease (CD) is important for appropriate therapy and prognosis. This study was designed to explore the utility of proteinase 3 anti-neutrophil cytoplasmic antibodies (PR3-ANCA) in the diagnosis of Chinese patients with inflammatory bowel disease (IBD).Methods: Blood samples were collected from 216 Chinese patients, including 175 IBD and 41 colorectal polyps (disease control). Clinical characteristics were extracted from electronic medical records.Results: Serum PR3-ANCA were increased in UC patients compared to those with CD or colorectal polyps (p < .0001). PR3-ANCA was negative in colorectal polyps and there was no significant difference between CD and colorectal polyps (p > .05). Using the cut-off value of 20 chemiluminescent units (CU) provided by manufacturer, the positive rate of PR3-ANCA was higher in UC than CD (41.7% vs. 1.1%; p < .0001). Receiver operating characteristic (ROC) analysis demonstrated an area under the curve (AUC) of 0.89 (95% CI: 0.84-0.95; p < .0001) for differentiating UC from CD and suggested an optimized cutoff of 7.3 CU which improved sensitivity from 41.7% to 57.1%, while maintaining a specificity of 98.9%. PR3-ANCA in severe UC patients were higher than those with moderate UC (p < .05), no difference was found between those in remission or with mild or moderate activity (p > .05).Conclusions: Serum PR3-ANCA is a potentially useful clinical biomarker in Chinese patients with IBD. A modified cut-off value of 7.3 CU improves the performance for distinguishing UC from CD.

5.
Spectrochim Acta A Mol Biomol Spectrosc ; 239: 118497, 2020 Oct 05.
Artigo em Inglês | MEDLINE | ID: mdl-32480273

RESUMO

A novel metal-organic complex (MOC) {[Eu2(HL)2(H2O)4]·3H2O}n (1) (H4L = 3,3',5,5'-azoxybenzenetetracarboxylic acid) has been successfully constructed, which exhibits a fascinating 2D bilayer network with the 1D open channels and has excellent water, pH and thermal stabilities. Luminescence studies reveal that 1 can detect TNP and CrO42- ions with high selectivity and sensitivity in aqueous solution, even if there are related interfering substances. And the mechanisms of luminescence recognitions are discussed on the basis of experiments and theoretical calculations. Furthermore, 1 shows excellent photostability and can be repeatedly used in the above two detection systems. Most importantly, 1 can detect TNP and CrO42- concentration with a good recovery rate in practical application. Therefore, 1 should be a potential dual-functional luminescent sensor for reliable sensing of TNP and CrO42- in the field.

6.
Nanotechnology ; 2020 Jun 29.
Artigo em Inglês | MEDLINE | ID: mdl-32599566

RESUMO

The separation of processing and memory units in the von Neumann architecture brings issues in energy consumption and speed mismatch, which is a huge obstacle on the road of integrated-circuits' development. Potentially, the excellent performance of two-dimensional (2D) materials field-effect transistor controlled by organic ferroelectric poly(vinylidene fluoride-trifluoroethylene) [P(VDF-TrFE)] polymer opens the way for the development of the next-generation microelectronics. Here, we combined P(VDF-TrFE) polymer and molybdenum disulfide (MoS2) nanoflakes to fabricate a horizontal dual-gate ferroelectric field-effect transistor (HDG-FeFET) device. For the first time, the fabricated HDG-FeFET can perform in-situ memory of the logic results while processing the AND logic function, which has great potential to remove the data movement. During the logic operations, the logic output state-1/state-0 current ratio approached 10e5. After 900 s, the corresponding non-volatile memory state-1/state-0 current ratio remains at 104. This type of transistor is expected to provide a promising in-memory computing solution for next-generation computing architecture that eliminates the Memory Wall.

7.
Mar Drugs ; 18(6)2020 Jun 18.
Artigo em Inglês | MEDLINE | ID: mdl-32570903

RESUMO

Marine-derived fungi are a significant source of pharmacologically active metabolites with interesting structural properties, especially terpenoids with biological and chemical diversity. In the past five years, there has been a tremendous increase in the rate of new terpenoids from marine-derived fungi being discovered. In this updated review, we examine the chemical structures and bioactive properties of new terpenes from marine-derived fungi, and the biodiversity of these fungi from 2015 to 2019. A total of 140 research papers describing 471 new terpenoids of six groups (monoterpenes, sesquiterpenes, diterpenes, sesterterpenes, triterpenes, and meroterpenes) from 133 marine fungal strains belonging to 34 genera were included. Among them, sesquiterpenes, meroterpenes, and diterpenes comprise the largest proportions of terpenes, and the fungi genera of Penicillium, Aspergillus, and Trichoderma are the dominant producers of terpenoids. The majority of the marine-derived fungi are isolated from live marine matter: marine animals and aquatic plants (including mangrove plants and algae). Moreover, many terpenoids display various bioactivities, including cytotoxicity, antibacterial activity, lethal toxicity, anti-inflammatory activity, enzyme inhibitor activity, etc. In our opinion, the chemical diversity and biological activities of these novel terpenoids will provide medical and chemical researchers with a plenty variety of promising lead compounds for the development of marine drugs.

8.
Biomed Res Int ; 2020: 1879640, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32509851

RESUMO

Allergic asthma is an inflammatory disease involving the Th1/Th2 cell imbalance in the peripheral blood. Repeated herbal acupoint sticking (RHAS) has been used for hundreds of years in China to relieve the recurrence of allergic asthma, and it is still practiced today. Thus, we explored the effect on allergic asthma relapse and the underlying immunoregulatory mechanism in this study. Here, we enrolled 50 allergic asthma participants, and 38 of them completed the treatment and follow-up (the allergic asthma group). In addition, 13 healthy participants (the control group) were enrolled. The recurrence number of allergic asthma participants and asthma control test (ACT) were used to evaluate the effect of treatment on relieving allergic asthma recurrence. Flow cytometry was performed to analyze the levels of Th1 and Th2 cells in the peripheral blood. The serum levels of IgE, IFN-γ, and IL-4 were detected by ELISA. (1) In the allergic asthma group, compared to before the first treatment, the recurrence number of allergic asthma participants decreased and the ACT score increased at end of the last treatment, 18 and 30 weeks of the trial (P < 0.05). At 18 and 30 weeks of the trial, the recurrence number of allergic asthma participants was less and the ACT score was higher than the ones from the same period last year in the allergic asthma group (P < 0.05). Compared to before the first treatment, the percentage of Th1 cell did not change significantly, the percentage of Th2 cell decreased, and the Th1/Th2 cell ratio increased in the allergic asthma group by the end of the last treatment (P < 0.05). Meanwhile, the release of IgE and IL-4 reduced (P < 0.05), and the release of IFN-γ did not significantly change in the allergic asthma group. (2) Compared with the control group, the serum levels of IgE and IL-4 and the percentage of Th2 cell were higher, and the Th1/Th2 cell ratio was lower in the allergic asthma group (P < 0.05). There was no significant difference between Th1 cell and IFN-γ before the first treatment. (3) Compared with the control group, the IgE levels and the percentage of Th2 cell were higher in the allergic asthma group (P < 0.01). Simultaneously, there was no significant difference between Th1 cell, the Th1/Th2 cell ratio, and the serum levels of IFN-γ and IL-4 by the end of the last treatment. The data suggested that RHAS reduced the amount of Th2 cell and elevated the Th1/Th2 cell ratio, thereby alleviating the inflammatory responses in the allergic asthma participants.

9.
J BUON ; 25(2): 1035-1041, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32521903

RESUMO

PURPOSE: This meta-analysis evaluated the potential influence of environmental radon exposure on childhood leukemia. METHODS: We searched comprehensive electronic databases from PubMed, EMBASE, and Cochrane Library to identify studies evaluating the association between radon and leukemia. RESULTS: Ten eligible studies published from 1995 to 2014 were enrolled. Of these 10 studies, 8 were case-control studies (involving 10803 cases and 16202 controls) and 2 were cohort studies (involving 1,428 cases). Overall results as odds ratio (OR) with the corresponding 95% confidence intervals (95%CI) for case-control studies and fully adjusted hazard ratio (HR) with corresponding 95%CI for cohort studies were identified. A positive but weak association was found between radon exposure and childhood leukemia in case-control studies (summary OR 1.22, 95%CI 1.01-1.42) rather than cohort studies (summary HR 0.97, 95%CI 0.81-1.15). Heterogeneity or publication bias was not observed. Moreover, overall ORs were not changed by removing any single study, suggesting the stability and reliability of conclusions. CONCLUSIONS: Future prospective studies with well-controlled confounders are needed to verify the conclusion.

10.
NPJ Biofilms Microbiomes ; 6(1): 20, 2020 Apr 29.
Artigo em Inglês | MEDLINE | ID: mdl-32350263

RESUMO

The perplexity of the complex multispecies community interactions is one of the many reasons why majority of the microorganisms are still uncultivated. We analyzed the entire co-occurrence networks between the OTUs of Tibet and Yunnan hot spring samples, and found that less abundant OTUs such as genus Tepidimonas (relative abundant <1%) had high-degree centricity (key nodes), while dominant OTUs particularly genus Chloroflexus (relative abundant, 13.9%) formed the peripheral vertexes. A preliminary growth-promotion assay determined that Tepidimonas sp. strain SYSU G00190W enhanced the growth of Chloroflexus sp. SYSU G00190R. Exploiting this result, an ameliorated isolation medium containing 10% spent-culture supernatant of Tepidimonas sp. strain SYSU G00190W was prepared for targeted isolation of Chloroflexi in the Tibet and Yunnan hot spring samples. 16S rRNA gene fingerprinting characterized majority of the colonies isolated from these media as previously uncultivated Chloroflexi, of which 36 are potential novel species (16S rRNA sequence identity <98.5%). Metabolomes studies indicated that the spent-culture supernatant comprises several low-molecular-weight organic substrates that can be utilized as potential nutrients for the growth of these bacteria. These findings suggested that limited knowledge on the interaction of microbes provide threshold to traditional isolation method.

11.
Diagn Pathol ; 15(1): 60, 2020 May 19.
Artigo em Inglês | MEDLINE | ID: mdl-32430068

RESUMO

BACKGROUND: Glioma-associated oncogene homolog 1 (Gli1), affects the progression and the stemness characteristics of malignant carcinoma. The aim of the present study was to identify the relation between Glioma-associated oncogene homolog 1 (Gli1) and stemness and determine its clinical significance in gastric adenocarcinoma (GA). We investigated Gli1 expression and its correlation with other stemness-associated proteins in 169 GA samples and 5 GA cell lines. METHODS: To elucidate the role of Gli1 in the clinicopathological significance and stemness of GA, tissues samples from 169 GA patients were collected for immunohistochemistry (IHC). Additionally, MKN74, MKN28, NCI-N87, SNU638, AGS cells were collected for western blotting, MKN28 cells were collected for spheroid formation assay. RESULTS: Results showed that Gli1 expression was closely related to tumor grade, primary tumor (pT) stage, distant metastasis, clinical stage, gross type, microvessel density, and shorter overall survival (OS). Cox regression analysis verified that Gli1 was an independent prognostic factor for OS. Furthermore, Gli1 expression correlated with the expression of stemness-related genes, CD44, LSD1, and Sox9. Gli1 inhibitor GANT61 significantly decreased the expression of CD44 and LSD1, and spheroid formation ability of the MKN28 cells. CONCLUSIONS: In conclusion, Gli1 may be a poor prognostic indicator and a potential cancer stemness-related protein in GA.

12.
J Int Med Res ; 48(5): 300060519894436, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-32374206

RESUMO

OBJECTIVE: To investigate ultrasonographic characteristics and diagnostic approaches of unruptured tubal pregnancy (UTP). METHODS: One hundred forty-six cases of early tubal pregnancy, which were confirmed surgically, were analyzed. RESULTS: Among 146 cases of UTP, 130 were diagnosed by ultrasonography. Furthermore, 16 cases of UTP were missed by ultrasonography. A total of 130 patients had a mass detected by ultrasonography, among whom the mass and ipsilateral ovary were distinguishable in 102. The embryo sac type was found in 40.00% (52/130), while the heterogeneous mass type was found in 60.00% (78/130) of patients. The maximum length and diameter of the ectopic pregnancy mass ranged from 10 to 68 mm (mean size, 26.42 ± 11.39 mm). No blood flow was observed in or around the mass in 67.69% (88/130) of patients. Lateral tubal thickening of the mass was found in 47.69% (62/130) of patients. Endometrial thickness was ≤10 mm in 67.80% (99/146) of patients. The intima was mostly hyperechoic in 72.60% (106/146) of patients. CONCLUSION: A paraovarian mass, thickened fallopian tube, uterine endometrium with a thickness of ≤10 mm, and high echo are important indicators of early UTP. Ultrasound examinations should focus on these indicators to help improve detection of early tubal pregnancy.

13.
Chem Biodivers ; 2020 May 30.
Artigo em Inglês | MEDLINE | ID: mdl-32472579

RESUMO

One new naphthalenone, didymelol A (1), and three new naphthols, didymelol B-D (5-7), together with three known naphthalenones, (3S,4R)-3,4,6,8-tetrahydroxy-3,4-dihydronaphthalen-1(2H)-one (2), (S)-4,6,8-trihydroxy-3,4-dihydronaphthalen-1(2H)-one (3), (S)-4,8-dihydroxy-3,4-dihydronaphthalen-1(2H)-one (4), were isolated from the Saussurea laniceps endophytic fungus Didymella glomerate X223. The structures of the isolates were elucidated based on extensive spectroscopic data analysis. The absolute configuration of didymelol A (1) was established through single-crystal X-ray diffraction data and didymelols B-D (5-7) were identified through comparisons of experimental and calculated ECD spectra. All compounds were evaluated for cytotoxic activity against human non-small cell lung cancer A549 cells and human breast carcinoma MDA-MB-435 cells.

14.
Anal Chem ; 92(11): 7462-7470, 2020 Jun 02.
Artigo em Inglês | MEDLINE | ID: mdl-32365292

RESUMO

Information about plant photosynthetic carbon assimilation, physiology, and biochemistry is locked in the 18O/16O ratios of the individual positions of higher plants carbohydrates but is under-utilized, because of the difficulty of making these determinations. We report the extension of the wet chemistry approach we used to access the 18O/16O ratio of O-3 of glucose with a novel GC/Pyrolysis/IRMS-based method, to determine the 18O/16O ratios of O-4, O-5, and O-6. The O atoms (OH groups) at positions 1, 2, 5, and 6 of glucose were protected by acetonation (converting to 1,2;5,6-di-O-isopropylidene-glucofuranose, DAGF). The DAGF was then converted to 6-bromo-6-deoxy-1,2;3,5-di-O-isopropylidene-glucofuranose (6-bromoDAGF) with the simultaneous removal of O-6 with N-bromosuccinimide and triphenylphosphine. The DAGF was also methylated at O-3 with CH3I under the catalysis of NaH to 3-methylDAGF, which was then deacetonated to 1,2-O-isopropylidene-3-O-methyl-glucofuranose (3-methylMAGF). O-5 and O-6 were then removed as a whole from 3-methylMAGF by I2 oxidization under the catalysis of Ph3P and imidazole. Isotope mass balance was then applied to calculate the 18O/16O of O-5 and O-6 as a whole and O-6, respectively. Sampling at different stages of substrate conversion to product and applying a Rayleigh-type fractionation model were employed, when quantitative conversion of substrate was unachievable to calculate the δ18O of the converted substrate. Quantitative conversion of glucose with phenylhydrazine to phenylglucosazone also allowed for the calculation of δ18O2 by applying isotope mass balance between the two. A C4 starch-derived glucose intramolecular δ18O profile is now determined: O-3 is relatively enriched (by 12.16 mUr), O-4 is relatively depleted (by 20.40-31.11 mUr), and O-2 is marginally enriched (by 2.40 mUr) against the molecular average.

15.
Environ Sci Technol ; 54(11): 6859-6868, 2020 Jun 02.
Artigo em Inglês | MEDLINE | ID: mdl-32421333

RESUMO

Nanoplastics (NPs; <0.1 µm) are speculated to be a bigger ecological threat due to their predicted wider distribution, higher concentrations, and bioavailability. Primary NPs are manufactured to be that size, while secondary NPs originate from fragmentation of bigger debris. To date, the long-term impact of NPs in freshwater systems, particularly secondary NPs, is not well-understood. Thus, we employed a freshwater invertebrate, Daphnia magna, to investigate the chronic effects of model primary NPs, fluorescent polystyrene nanospheres (PS-NPs; 20 nm), and water leachate of weathered single-use plastics that contained micro- and nanosized particles. In experiment 1, parent Daphnia (F0) were exposed to 1 and 50 mg/L PS-NPs until the production of the neonates (F1) followed by a two-generation recovery. PS-NPs were mainly detected in the intestine and brood chamber in F0 and transferred to F1 and F2. PS-NPs significantly decreased the appendage curling and heartbeat rate in F0 and reduced reproduction in F2. In experiment 2, the plastic leachate also reduced the appendage curling rate but increased growth and reproduction. The results suggest that the acute toxicity of primary and secondary plastic particles is low even at high concentrations, but their chronic and sublethal effects should not be overlooked.

16.
Food Chem ; 326: 126983, 2020 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-32413763

RESUMO

Confirmed to be a new type of food resource, quail egg can provide humans with high-quality protein and offer various nutrients that can promote growth and development. Post-translational modification of proteins can regulate their molecular structures and physiological functions. However, the understanding and related research of quail egg holoproteins and post-translationally modified proteins is not yet sufficient. This study provides an in-depth analysis of quail egg proteins using an omics strategy. A total of 175 proteins, 109 N-glycoproteins (293 N-glycosylation sites) and 23 phosphoproteins (84 phosphorylation sites) were identified. Motif analysis showed that N-glycosylation sites of quail eggs were classical sites. The main characteristic sequence of the phosphorylation site is "S-X-E" (77%). Functional analysis indicated that quail egg proteins, modified proteins were enriched in the regulation of enzyme activity. These results have significant reference value for understanding the structure, function of quail eggs, explaining the physicochemical reaction during the storage.

17.
Arch Pharm (Weinheim) ; : e2000025, 2020 May 08.
Artigo em Inglês | MEDLINE | ID: mdl-32383190

RESUMO

Cancer can invade or spread to almost all parts of the body. The increasing morbidity and high mortality of cancer create a great demand for the development of novel anticancer drugs. Coumarin derivatives are ubiquitous in nature and can readily interact with diverse enzymes and receptors in cancer cells via weak bond interactions; hence, coumarin is a highly privileged pharmacophore for the development of novel anticancer agents. This review will focus on the recent development of coumarin hybrids as potential anticancer agents covering articles published from 2019 to 2020.

18.
Nurs Health Sci ; 2020 May 27.
Artigo em Inglês | MEDLINE | ID: mdl-32462790

RESUMO

This study aimed to translate the Perspectives on Caring for Older Patients scale into Chinese, both the full and the shortened versions, and test its psychometric properties among Chinese nursing students. In this methodological research, the scale were translated and administered to 307 nursing students recruited from two universities in mainland China. The psychometric testing mainly included internal consistency reliability using Cronbach's alphas, 2-week test-retest reliability using the intraclass correlation coefficient, convergent validity with Kogan's Attitude toward Older People scale, and factorial validity using exploratory factor analysis. Cronbach's alphas for the full and the shortened version scales were 0.77 and 0.75, respectively. The intraclass correlation coefficient values of both versions exceeded 0.70 and their scores were moderately correlated with the Kogan's Attitude toward Older People scale's scores. While exploratory factor analyses revealed a six-factor structure for the full version with factor loadings of five items below 0.3, the shortened version identified two factors with all factor loadings above 0.3. This study concluded that the psychometric properties of the full version scale were adequate and similar to those of the shortened version except for factorial validity.

19.
J Agric Food Chem ; 68(22): 6104-6111, 2020 Jun 03.
Artigo em Inglês | MEDLINE | ID: mdl-32362125

RESUMO

Human milk contains several bioactive proteins, including lactoferrin (LF) and osteopontin (OPN). These two proteins have been shown to form a complex, which shows increased bioactivities. Bovine LF and OPN can also form such a complex. We assessed bioactivities of the bovine LF-OPN complex (at molar ratios of LF:OPN = 3:1, 5:1, or 8:1) in a formula protein matrix, including LF, OPN, bovine whey protein hydrolysate, and α-lactalbumin. Our results show that the bovine LF-OPN complex together with formula proteins is resistant to in vitro digestion, stimulates intestinal cell proliferation (by 15-50%) and differentiation (by 30-50%), increases antibacterial activity (by 25-50%), and enhances intestinal immunity. The 3:1 ratio of LF to OPN exhibits the most potent effects, as compared with the other two ratios. In conclusion, adding bovine LF and OPN to infant formulas may result in increased stability of the two components and enhanced bioactivities, possibly improving outcomes in formula-fed infants.

20.
J Affect Disord ; 274: 223-228, 2020 May 23.
Artigo em Inglês | MEDLINE | ID: mdl-32469808

RESUMO

BACKGROUND: A positive association between early-life famine exposure and depression has been demonstrated. However, the mechanisms by which famine exposure in early life leads to late-life depression remains unclear. The present study examines the impact of leukocyte telomere length (LTL) and/or religiosity on the relationship between early-life famine exposure and late-life depression in a Chinese minority sample. METHODS: A cross-sectional study of community-dwelling adults aged 55 or older was conducted in the Ningxia province of western China from 2013 to 2016. Multivariate ordinal logistic regression was used to examine the association between famine exposure and depression status, and a series mediation model was constructed to identify the mediation role of LTL and religiosity. RESULTS: Compared with famine exposure during adulthood, fetal famine exposure was associated with a higher risk of late-life depression (adjusted odds ratio of 3.17, 95% CI: 1.36-7.38). A cumulative effect of fetal famine exposure on the risk of late-life depression was observed. Participants born in 1961 (the third year of the famine) had the strongest association with late-life depression. LTL played a mediating role in the association between famine exposure and depression which accounted for 21% of the total effect. LIMITATIONS: The cross-sectional design prevents causal inferences regarding the relationships between famine and depression. CONCLUSIONS: Fetal famine exposure was associated with an increased risk of late-life depression in a Chinese minority community-dwelling population. Telomere shortening partially mediated this association.

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