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1.
Adv Mater ; : e1907604, 2020 Feb 05.
Artigo em Inglês | MEDLINE | ID: mdl-32022965

RESUMO

Morphology tuning of the blend film in organic solar cells (OSCs) is a key approach to improve device efficiencies. Among various strategies, solid additive is proposed as a simple and new way to enable morphology tuning. However, there exist few solid additives reported to meet such expectations. Herein, chlorine-functionalized graphdiyne (GCl) is successfully applied as a multifunctional solid additive to fine-tune the morphology and improve device efficiency as well as reproductivity for the first time. Compared with 15.6% efficiency for control devices, a record high efficiency of 17.3% with the certified one of 17.1% is obtained along with the simultaneous increase of short-circuit current (Jsc ) and fill factor (FF), displaying the state-of-the-art binary organic solar cells at present. The redshift of the film absorption, enhanced crystallinity, prominent phase separation, improved mobility, and decreased charge recombination synergistically account for the increase of Jsc and FF after introducing GCl into the blend film. Moreover, the addition of GCl dramatically reduces batch-to-batch variations benefiting mass production owing to the nonvolatile property of GCl. All these results confirm the efficacy of GCl to enhance device performance, demonstrating a promising application of GCl as a multifunctional solid additive in the field of OSCs.

2.
Med Sci Monit ; 26: e919103, 2020 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-31937750

RESUMO

BACKGROUND The function of long non-coding RNA (lncRNA) BMP/OP-responsive gene (BORG) has only been studied in breast cancer. We analyzed the role of BORG in colorectal cancer (CRC). MATERIAL AND METHODS BORG in CRC tissues and non-cancer tissues from 66 CRC patients was detected by performing quantitative reverse-transcription PCR (RT-qPCR). BORG in plasma of CRC patients was detected at 3 times-points: before treatment and at 3 and 6 months after treatment. p53 expression in tumor tissues was also detected by RT-qPCR. QPCR was performed to confirm the overexpression of p53 in cells of both CRC cell lines. RESULTS We found that BORG expression was upregulated in CRC tissues and was inversely correlated with p53. With application of carboplatin-based treatment, the expression level of BORG was further upregulated. In CRC cells, carboplatin upregulated the expression of BORG and BORG negatively regulated p53. Under carboplatin treatment, BORG positively regulated the viability of CRC cells. In addition, p53 overexpression attenuated the effects of BORG overexpression. CONCLUSIONS BORG promotes the development of chemoresistance of CRC cells to carboplatin.

3.
Fitoterapia ; 140: 104441, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31778760

RESUMO

In the present work, we reported the triterpenoids isolated from n-butanol fraction of Kadsura heteroclita which is a Tujia ethnomedicine with trivial name "Xuetong". This effort resulted in the isolation of six unpresented triterpenoids xuetongsu A-F (1-6), along with five known triterpenoids (7-11). The structures of the reported compounds were established on the 1D, and 2D NMR and HRESIMS spectra, along with CD spectroscopic analysis. Moreover, the absolute stereochemistry of compound 7 was determined by X-ray diffraction analysis. Antioxidant and cytotoxic activities were evaluated for all isolated compounds, compound 7 shown weak cytotoxic activity against HL-60 with IC50 value of 50.0 µM.


Assuntos
Kadsura/química , Caules de Planta/química , Triterpenos/química , China , Células HL-60 , Humanos , Estrutura Molecular , Compostos Fitoquímicos/química , Compostos Fitoquímicos/isolamento & purificação , Triterpenos/isolamento & purificação
4.
Chemosphere ; 242: 125165, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-31698211

RESUMO

Bisphenol S (BPS), regarded as a valid alternative to Bisphenol A (BPA), has been found to induce acute toxicity, genotoxicity. In this paper, BPS pollution was repaired by corn straw biochar, and the effect of dissolved organic matter (DOM) on the remediation mechanism was investigated. Different DOMs were obtained by decomposing corn straw in red soil, yellow soil and brown soil. The DOMs were characterized by Elemental analysis, Fourier infrared spectroscopy (FT-IR), ultraviolet-visible spectroscopy (Uv-vis) spectroscopy, Three-dimensional excitation-emission matrix (3D-EEM). Different kinds of DOMs were added into the biochar adsorption system to determine the optimal pH, optimal dosage, equilibrium adsorption capacity, adsorption kinetics, adsorption isotherms, thermodynamic characteristics, and explore the influence mechanism of DOM on the adsorption of BPS by biochar. The results of the adsorption experiments showed that DOM would suppress the BPS adsorption capacity on biochar. In addition, the DOM, produced by decomposition of corn straw with brown soil, had the strongest inhibitory effect on adsorption, and red soil was the soil with the lowest inhibitory effect on organic pollution removal by biochar.

5.
J Neuroinflammation ; 16(1): 249, 2019 Dec 03.
Artigo em Inglês | MEDLINE | ID: mdl-31796106

RESUMO

BACKGROUND: Inflammation can induce cognitive dysfunction in patients who undergo surgery. Previous studies have demonstrated that both acute peripheral inflammation and anaesthetic insults, especially isoflurane (ISO), are risk factors for memory impairment. Few studies are currently investigating the role of ISO under acute peri-inflammatory conditions, and it is difficult to predict whether ISO can aggravate inflammation-induced cognitive deficits. HDACs, which are essential for learning, participate in the deacetylation of lysine residues and the regulation of gene transcription. However, the cell-specific mechanism of HDACs in inflammation-induced cognitive impairment remains unknown. METHODS: Three-month-old C57BL/6 mice were treated with single versus combined exposure to LPS injected intraperitoneally (i.p.) to simulate acute abdominal inflammation and isoflurane to investigate the role of anaesthesia and acute peripheral inflammation in cognitive impairment. Behavioural tests, Western blotting, ELISA, immunofluorescence, qRT-PCR, and ChIP assays were performed to detect memory, the expressions of inflammatory cytokines, HDAC2, BDNF, c-Fos, acetyl-H3, microglial activity, Bdnf mRNA, c-fos mRNA, and Bdnf and c-fos transcription in the hippocampus. RESULTS: LPS, but not isoflurane, induced neuroinflammation-induced memory impairment and reduced histone acetylation by upregulating histone deacetylase 2 (HDAC2) in dorsal hippocampal CaMKII+ neurons. The hyperexpression of HDAC2 in neurons was mediated by the activation of microglia. The decreased level of histone acetylation suppressed the transcription of Bdnf and c-fos and the expressions of BDNF and c-Fos, which subsequently impaired memory. The adeno-associated virus ShHdac2, which suppresses Hdac2 after injection into the dorsal hippocampus, reversed microglial activation, hippocampal glutamatergic BDNF and c-Fos expressions, and memory deficits. CONCLUSIONS: Reversing HDAC2 in hippocampal CaMKII+ neurons exert a neuroprotective effect against neuroinflammation-induced memory deficits.

6.
Artigo em Inglês | MEDLINE | ID: mdl-31873892

RESUMO

As the shortage of non-renewable fossil fuels, the renewable fuels should be further developed. Biomass energy has emerged the great utilization potential, and liquefaction of biomass is a typical technology. This paper studied the effect of the operation parameters on the hydrothermal liquefaction of corn straw using a batch reactor, including liquefaction temperature, initial pressure, retention time, solvent, and catalyst. The optimal liquefaction conditions for corn straw were 300 °C under 4 MPa for 15 min using the mixture of water and methanol as the solvent. After the addition of catalyst, NKC-11 catalyst showed the excellent performance, and the primary components were phenol and derivatives, alkane, furan, and the low concentration of organic acids. Lastly, the life cycle assessment on the hydrothermal liquefaction of corn straw for bio-oil production was executed. The results of LCA suggested that a net 1.31 kg of CO2 equivalent was produced for 1 kg of bio-oil product without considering syngas, while the value changed to 13.03 kg with considering syngas. Moreover, the results of sensitivity analysis further suggested that the syngas was a key factor on the environmental impacts in the hydrothermal liquefaction of corn straw process.

7.
BMC Plant Biol ; 19(1): 514, 2019 Nov 25.
Artigo em Inglês | MEDLINE | ID: mdl-31767006

RESUMO

BACKGROUND: Plant defense against herbivores begins with perception. The earlier plant detects the harm, the greater plant will benefit in its arm race with the herbivore. Before feeding, the larvae of the rice pest Cnaphalocrocis medinalis, initially spin silk and fold up a leaf. Rice can detect and protect itself against C. medinalis feeding. However, whether rice could perceive C. medinalis leaf rolling behavior is currently unknown. Here, we evaluated the role of leaf rolling by C. medinalis and artificial leaf rolling in rice plant defense and its indirect effect on two important C. medinalis parasitoids (Itoplectis naranyae and Apanteles sp.) through a combination of volatile profiling, gene-transcriptional and phytohormonal profiling. RESULTS: Natural leaf rolling by C. medinalis resulted in an increased attraction of I. naranyae when compared to the undamaged plant after 12 h. Volatile analysis revealed that six out of a total 22 components significantly increased in the headspace of C. medinalis rolled plant when compared to undamaged plant. Principal component analysis of these components revealed similarities in the headspace of undamaged plant and artificially rolled plant while the headspace volatiles of C. medinalis rolled plant deferred significantly. Leaf rolling and feeding by C. medinalis up-regulated the plant transcriptome and a series of jasmonic acid (JA) and salicylic acid (SA) related genes. While feeding significantly increased JA level after 12 to 36 h, rolling significantly increased SA level after 2 to 12 h. Compared to artificial rolling, natural rolling significantly increased JA level after 36 h and SA level after 2 and 12 h. CONCLUSIONS: Our findings suggest that natural leaf rolling by C. medinalis can be perceived by rice plant. The detection of this behavior may serve as an early warning signal in favor of the rice plant defenses against C. medinalis.

8.
Front Mol Neurosci ; 12: 246, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31708739

RESUMO

Brain-derived neurotrophic factor (BDNF) is essential for cognitive and memory functions. Abnormal BDNF expression in the central nervous system may impair these functions. Anaesthesia and surgery can induce perioperative neurocognitive disorders (PND). Clinical studies show that BDNF expression is decreased in patients presenting with cognitive impairment after anaesthesia and surgery. However, the molecular mechanism is still unclear. Epigenetic regulation plays an important role in cognition. The hypermethylation of H3K9 is crucial for transcriptional silencing and the onset of cognitive disorders. Here, we hypothesised that H3K9 trimethylation repressed BDNF expression and impaired memory formation or recall during anaesthesia and surgery. Laparotomy under isoflurane inhalation anaesthesia, behavioural tests, Western blotting, quantitative real-time reverse-transcription polymerase chain reaction (qRT-PCR), chromatin immunoprecipitation (ChIP), and immunohistochemistry were used in this study. BDNF expression was decreased in the hippocampus after anaesthesia and surgery. Cognitive impairment affected memory formation but not recall. The trimethylation of H3K9 downregulated BDNF expression. The overexpression of BDNF or use of exogenous BDNF improved the impairment of memory formation caused by anaesthesia and surgery. Therefore, inhibiting H3K9 trimethylation and increasing the expression of BDNF may help prevent PND in the clinical setting.

9.
Nat Commun ; 10(1): 5286, 2019 Nov 21.
Artigo em Inglês | MEDLINE | ID: mdl-31754107

RESUMO

Understanding spatial distribution difference and reaction kinetics of the electrode is vital for enhancing the electrochemical reaction efficiency. Here, we report a total internal reflection imaging sensor without background current interference to map local current distribution of the electrode in a vanadium redox flow battery during cyclic voltammetry (CV), enabling mapping of the activity and reversibility distribution with the spatial resolution of a single fiber. Three graphite felts with different activity are compared to verify its feasibility. In long-term cyclic voltammetry, the oxygen evolution reaction is proved to enhance activity distribution, and homogeneity of the electrode and its bubble kinetics with periodic fluctuation is consistent with the cyclic voltammetry curve, enabling the onset oxygen evolution/reduction potential determination. Higher activity and irreversibility distribution of the electrode is found in favor of the oxygen evolution reaction. This sensor has potential to detect in situ, among other processes, electrochemical reactions in flow batteries, water splitting, electrocatalysis and electrochemical corrosion.

10.
Curr Biol ; 29(16): 2604-2615.e2, 2019 Aug 19.
Artigo em Inglês | MEDLINE | ID: mdl-31402300

RESUMO

Since the Late Paleozoic, forests have become distributed worldwide and significantly changed the Earth's climate and landscapes, but the record of forests is rare in the Devonian (419-359 Ma in age) when they first appeared. From the Upper Devonian (Famennian with the age of 372-359 Ma) of Xinhang, Anhui, China, we report a very large in situ forest, which includes locally dense stands of lycopsid plants. The Xinhang forest is monospecific with a small tree lycopsid Guangdedendron gen. nov., probably dioecious with monocarpic reproduction. The plant shows the earliest stigmarian rooting system typical of giant tree lycopsids dominating Carboniferous forests. It colonizes coastal clastic wetlands that were influenced by floods. This significantly increases the paleogeographical coverage of in situ Devonian forests, and contributes to our understanding of atmospheric CO2 decline and coastal consolidation.

11.
Biomed Pharmacother ; 118: 109198, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31336342

RESUMO

ω-3 fish oil fat emulsions contain a considerable quantity of unsaturated carbon-carbon double bonds, which undergo lipid peroxidation to yield low-dose aldehydes. These aldehydes may stimulate the production of antioxidant enzymes, thereby mitigating myocardial oxidative damage. This study aims to (1) verify the cardioprotective effect of ω-3 fish oil fat emulsion in vivo and in vitro, and (2) determine whether aldehyde stress is a protective mechanism. For modeling purposes, we pretreated rats with 2 ml/kg of a 10% ω-3 fish oil fat emulsion for 5 days in order to generate a sufficient aldehyde stress response to trigger the production of antioxidant enzymes, and we obtained similar response with H9C2 cells that were pretreated with a 0.5% ω-3 fish oil fat emulsion for 24 h. ω-3 fish oil fat emulsion pretreatment in vivo reduced the myocardial infarct size, decreased the incidence of arrhythmias, and promoted the recovery of cardiac function after myocardial ischemia/reperfusion injury. Once the expression of nuclear factor E2-related factor 2 (Nrf2) was silenced in H9C2 cells, aldehydes no longer produced enough antioxidant enzymes to reverse the oxidative damage caused by tert-butyl hydroperoxide (TBHP). Our results demonstrated that ω-3 fish oil fat emulsion enhanced the inhibition of oxidation and production of free radicals, and alleviated myocardial oxidative injury via activation of the Nrf2 signaling pathway.

12.
Adv Sci (Weinh) ; 6(11): 1802046, 2019 Jun 05.
Artigo em Inglês | MEDLINE | ID: mdl-31179207

RESUMO

Photovoltaic devices employing lead halide perovskites as the photoactive layer have attracted enormous attention due to their commercialization potential. Yet, there exists challenges on the way to the practical use of perovskite solar cells (PSCs), such as light stability and current-voltage (J-V ) hysteresis. Inorganic perovskite nanocrystals (IPNCs) are promising candidates for high-performance photovoltaic devices due to their simple synthesis methods, tunable bandgap, and efficient photon downshifting effect for ultraviolet (UV) light blocking and conversion. In this work, CsPbBr3 IPNCs modification could give rise to the vapor phase and solution-processed PSCs with a power conversion efficiency (PCE) of 16.4% and 20.8%, respectively, increased by 11.6% and 5.6% compared to the control devices for more efficient UV utilization and carrier recombination suppression. As far as is known, 11.6% is the most effective enhanced factor for PSCs based on photon downshifting effect inside of devices. The CsPbBr3 layer could also significantly retard light-induced degradation, leading to the lifetime over 100 h under UV illumination for PSCs. Additionally, the modified PSCs exhibit weak hysteresis and multiple colors of fluorescence. These results shed light on the future design of combining a photon downshifting layer and carrier interfacial modification layer in the applications of perovskite optoelectronic devices.

13.
Molecules ; 24(12)2019 Jun 17.
Artigo em Inglês | MEDLINE | ID: mdl-31212889

RESUMO

The liquefaction of biomass is an important technology to converse the biomass into valuable biofuel. The common technologies for liquefaction of biomass are indirect liquefaction and direct liquefaction. The indirect liquefaction refers to the Fischer-Tropsch (F-T) process using the syngas of biomass as the raw material to produce the liquid fuel, including methyl alcohol, ethyl alcohol, and dimethyl ether. The direct liquefaction of biomass refers to the conversion biomass into bio-oil, and the main technologies are hydrolysis fermentation and thermodynamic liquefaction. For thermodynamic liquefaction, it could be divided into fast pyrolysis and hydrothermal liquefaction. In addition, this review provides an overview of the physicochemical properties and common upgrading methods of bio-oil.


Assuntos
Biomassa , Óleos Vegetais/química , Polifenóis/química , Biocombustíveis , Parede Celular/química , Celulose/química , Etanol/metabolismo , Fermentação , Hidrólise , Células Vegetais , Temperatura Ambiente , Termodinâmica
14.
Front Immunol ; 10: 1324, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31249571

RESUMO

Disordered intestinal flora and discordant immune response are associated with the development of ulcerative colitis (UC). Recent work has described the ability of macrophages to undergo repolarization toward a proinflammatory M1 or anti-inflammatory M2 phenotype in response to particular bacterium-derived signals. Fusobacterium nucleatum (F. nucleatum, Fn) is a species of intestinal commensal bacteria with potential pathogenicity, but its association with UC and how it may contribute to progression of UC is largely unknown. In this study, we provide new evidence that F. nucleatum accumulated heavily in the intestine of UC patients and was accompanied by the secretion of IFN-γ and the skewing of M1 macrophages. Mechanistically, our data showed that F. nucleatum aggravated dextran sodium sulfate (DSS)-induced colitis in the production of Th1-related cytokines IFN-γ through the AKT2 signaling pathway in vitro and in vivo. To further confirm the disease-relevance of these shifts in macrophage repolarization in response to F. nucleatum, stimulated bone marrow-derived macrophages (BMDMs) were transferred into recipient mice with DSS colitis. This transfer resulted in increased disease activity and inflammatory cytokine production. Taken together, we show clearly that F. nucleatum can promote the progression of UC via proinflammatory M1 macrophage skewing, and targeting F. nucleatum or AKT2 signaling may be a viable means of blocking development of UC.

15.
BMC Plant Biol ; 19(1): 164, 2019 Apr 27.
Artigo em Inglês | MEDLINE | ID: mdl-31029105

RESUMO

BACKGROUND: Circular RNAs (circRNAs) are 3'-5' head-to-tail covalently closed non-coding RNA that have been proved to play essential roles in many cellular and developmental processes. However, no information relate to cucumber circRNAs is available currently, especially under salt stress condition. RESULTS: In this study, we sequenced circRNAs in cucumber and a total of 2787 were identified, with 1934 in root and 44 in leaf being differentially regulated under salt stress. Characteristics analysis of these circRNAs revealed following features: most of them are exon circRNAs (79.51%) and they prefer to arise from middle exon(s) of parent genes (2035/2516); moreover, most of circularization events (88.3%) use non-canonical-GT/AG splicing signals; last but not least, pairing-driven circularization is not the major way to generate cucumber circRNAs since very few circRNAs (18) contain sufficient flanking complementary sequences. Annotation and enrichment analysis of both parental genes and target mRNAs were launched to uncover the functions of differentially expressed circRNAs induced by salt stress. The results showed that circRNAs may be paly roles in salt stress response by mediating transcription, signal transcription, cell cycle, metabolism adaptation, and ion homeostasis related pathways. Moreover, circRNAs may function to regulate proline metabolisms through regulating associated biosynthesis and degradation genes. CONCLUSIONS: The present study identified large number of cucumber circRNAs and function annotation revealed their possible biological roles in response to salt stress. Our findings will lay a solid foundation for further structure and function studies of cucumber circRNAs.


Assuntos
Cucumis sativus/genética , Cucumis sativus/fisiologia , RNA de Plantas/genética , RNA/genética , Estresse Salino/genética , Sequência de Bases , Biomassa , Cucumis sativus/crescimento & desenvolvimento , Éxons/genética , Regulação da Expressão Gênica de Plantas , Ontologia Genética , Redes Reguladoras de Genes , Genes de Plantas , Transporte de Íons , MicroRNAs/genética , MicroRNAs/metabolismo , Anotação de Sequência Molecular , Raízes de Plantas/genética , Raízes de Plantas/fisiologia , RNA/metabolismo , RNA Mensageiro/genética , RNA Mensageiro/metabolismo , RNA de Plantas/metabolismo
16.
J Agric Food Chem ; 67(15): 4355-4366, 2019 Apr 17.
Artigo em Inglês | MEDLINE | ID: mdl-30919632

RESUMO

The crystal structure of Dextranase from the marine bacterium Arthrobacter oxidans KQ11 (Aodex) was determined at a resolution of 1.4 Å. The crystal structure of the conserved Aodex fragment (Ala52-Thr638) consisted of an N-terminal domain N and a C-terminal domain C. The N-terminal domain N was identified as a ß-sandwich, connected to a right-handed parallel ß-helix at the C-terminus. Sequence comparisons, cavity regions, and key residues of the catalytic domain analysis all suggested that the Aodex was an inverting enzyme, and the catalytic acid and base were Asp439 and Asp420, respectively. Asp440 was not a general base in the Aodex catalytic domain, and Asp396 in Dex49A may not be a general base in the catalytic domain. The thermostability of the S357F mutant using semirational design based on B-factors was clearly better than that of wild-type Aodex. This process may promote the aromatic-aromatic interactions that increase the thermostability of mutant Phe357.


Assuntos
Arthrobacter/enzimologia , Proteínas de Bactérias/química , Proteínas de Bactérias/metabolismo , Dextranase/química , Dextranase/metabolismo , Arthrobacter/química , Arthrobacter/genética , Proteínas de Bactérias/genética , Catálise , Domínio Catalítico , Cristalografia por Raios X , Estabilidade Enzimática , Temperatura Alta , Modelos Moleculares
17.
ACS Appl Mater Interfaces ; 11(12): 11481-11487, 2019 Mar 27.
Artigo em Inglês | MEDLINE | ID: mdl-30839191

RESUMO

Organic-inorganic lead halide perovskite solar cells (PSCs) exhibit spectacular changes in the photovoltaic area, but they still face the challenges of full spectral utilization and photostability under continuous light irradiation. The ultraviolet (UV) part in sunlight could induce oxygen vacancy in the mesoporous TiO2 (m-TiO2) layer, resulting in the degradation of perovskite photoactive films and the rapidly decreased device performance. In this work, we demonstrate that an effective luminescent downconversion material, Eu(TTA)2(Phen)MAA (ETPM), can be used as an interfacial modifier between the m-TiO2 layer and the perovskite photoactive layer to improve the power conversion efficiency (PCE) from 17.00 to 19.07%. The improved device performance can be ascribed to the effective utilization of incident UV light and reduced carrier recombination. Meanwhile, the conversion of the UV light by ETPM could inhibit the stability loss of the device under irradiation. As a result, the modified PSCs can maintain 86% of their initial value under continuous light soaking for 100 h, higher than that of 40% for the control device. This work indicates that the introduction of the luminescent downconversion material ETPM can successfully improve the PCE and photostability of PSCs.

18.
Artigo em Inglês | MEDLINE | ID: mdl-30832410

RESUMO

Bisphenol S (BPs) has been found in a variety of common consumer products surrounding human living, despite the fact that it could damage the human digestive system and genital system. In China, straw-returning to the field is a common soil improvement technology used to increase the concentration of dissolved organic matter (DOM), which plays an important role in the natural environment as a microreactor of contaminants. Additionally, the biochar obtained by the straw is an effective soil conditioner. DOM is a key influencing factor when biochar is employed as the conditioner of BPs contaminated soil. However, the BPs adsorption behavior on the Ferralsol affected by DOM and biochar is also unclear. Hence, DOM was prepared and the effect of DOM on the BPs adsorption behavior on soil and biochar modified soil was investigated. DOM was characterized by Elemental analysis, Fourier transforming infrared spectra (FT-IR), and three-dimensional excitation-emission matrix spectra (3D-EEM). The results of the adsorption experiments indicated that both biochar and DOM could improve the BPs adsorption capacity in Ferralsol, while DOM suppressed the BPs adsorption capacity of biochar modified soil, indicating that DOM and BPs could not be applied at the same time for BPs adsorption.


Assuntos
Carvão Vegetal/química , Recuperação e Remediação Ambiental/métodos , Compostos Orgânicos/química , Fenóis/química , Poluentes do Solo/química , Solo/química , Sulfonas/química , Adsorção , China
19.
Neuro Oncol ; 21(6): 800-808, 2019 06 10.
Artigo em Inglês | MEDLINE | ID: mdl-30726976

RESUMO

BACKGROUND: Dysembryoplastic neuroepithelial tumors (DNETs) are uncommon neural tumors presenting most often in children and young adults and associated with intractable seizures. Rare midline neoplasms with similar histological features to those found in DNETs have been described near the septum pellucidum and termed "DNET-like neoplasms of the septum pellucidum." Due to their rarity, these tumors have been described in just a few reports and their genetic alterations sought only in small series. METHODS: We collected 20 of these tumors for a comprehensive study of their clinical, radiological, and pathological features. RNA sequencing or targeted DNA sequencing was undertaken on 18 tumors, and genome-wide DNA methylation profiling was possible with 11 tumors. Published cases (n = 22) were also reviewed for comparative purposes. RESULTS: The commonest presenting symptoms and signs were related to raised intracranial pressure; 40% of cases required cerebrospinal fluid diversion. Epilepsy was seen in approximately one third of cases. All patients had an indolent disease course, despite metastasis within the neuraxis in a few cases. Radiologically, the septum verum/septal nuclei were involved in all cases and are the proposed site of origin for septal DNET (sDNET). Septal DNET showed a high frequency (~80%) of mutations of platelet derived growth factor receptor A (PDGFRA), and alterations in fibroblast growth factor receptor 1 (FGFR1) and neurofibromatosis type 1 (NF1) were also identified. In a genomic DNA methylation analysis alongside other neural tumors, sDNETs formed a separate molecular group. CONCLUSIONS: Genetic alterations that are different from those of cerebral DNETs and a distinct methylome profile support the proposal that sDNET is a distinct disease entity.

20.
Behav Brain Res ; 364: 75-84, 2019 05 17.
Artigo em Inglês | MEDLINE | ID: mdl-30753876

RESUMO

Chronic stress is an important factor for depression. Most individuals recover from stress, while some develop into depression. The pathogenesis of resilience or susceptibility remains unclear. Stress activates the hypothalamic-pituitary-adrenal (HPA) axis and releases stress hormones to regulate individual response to stress. Hence, we assessed the effects of chronic social defeat stress (CSDS) on susceptible behaviors, plasma corticosterone (CORT) concentration, glucocorticoid receptor (GR) expressions in hippocampus and medial prefrontal cortex (mPFC). Mice that plasma CORT concentration is increased 2 h after single social defeat stress developed into susceptible mice after 10 d social defeat stress. The plasma CORT concentration was still higher than that of resilient mice 48 h after the last defeat stress. Mice administered CORT via drinking water showed susceptibility. Mifepristone, a GR antagonist improved susceptibility to chronic stress. Single dose ketamine treatment improved depressive-like behaviors, decreased plasma CORT concentration, rescued GR expression and nuclear translocation in the hippocampus of susceptible mice. These results suggested that abnormal CORT concentration after stress may predict susceptibility to depression in clinic. Ketamine may exert the antidepressant effect via normalizing HPA axis response and have significance in the clinic.

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