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1.
Microb Pathog ; 136: 103721, 2019 Sep 05.
Artigo em Inglês | MEDLINE | ID: mdl-31494298

RESUMO

Acute lung Injury (ALI) is the clinical syndrome of parenchymal lung disease, leading to an extremely high mortality. The pathogenesis of ALI is suggested to be a consequence of uncontrolled inflammation. Lipopolysaccharide (LPS)-induced ALI mice model is often used for the mechanism. Studies show that TGF-beta activated kinase 1 (MAP3K7) binding protein 1/2 (TAB2) plays a crucial role in LPS-induced inflammation response. Furthermore, microRNA-142a-3p (miR-142a-3p) has been observed to be involved in inflammation-induced disease. Thus, we investigated the role of miR-142a-3p and TAB2 on LPS-induced ALI, which involved the TLR4/TAB2/NF-κB signaling. ALI and normal lung tissues were collected to access the relative expression of pro-inflammatory cytokines and miR-142a-3p. Histopathological examination and Wet to Dry weight ratios of lung tissues were used to access the establishment of ALI models. Raw264.7 cells were transfected with si-TAB2 or miR-142a-3p mimics to elucidate the role of TAB2 or miR-142a-3p in the inflammatory cascade in ALI. Additionally, the relationship between miR-142a-3p and TAB2 was validated by dual-luciferase report system. Our study discovered that miR-142-3p was up-regulated both in LPS-induced ALI mice model and RAW264.7 cells model. MiR-142a-3p mimics group experienced significant decrease in the secretion of pro-inflammatory cytokines as a result of the inhibition of NF-κB signaling pathway. Bioinformatics database showed that the adaptor protein, TAB2, was critical in this pathway and it is the target gene of miR-142a-3p. Their relation was first confirmed by us via dual-luciferase report system. Results of our study demonstrated that miR-142a-3p exerts as a protective role in LPS-induced ALI through down-regulation of NF-κB signaling pathway.

2.
Chemosphere ; 226: 907-914, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31509920

RESUMO

The isomorphous substitution in the structure of phyllosilicate minerals plays an important role in regulating of surface chemical properties. In this work, iron muscovite nanoparticles with various Al species were successfully prepared to explore the structural Fe and Al species on the capture of Cd(II) from solutions. The synthesized nanocrystals have irregular shapes with diameters of 10-50 nm. The incorporation of Al(III) into the iron muscovite nanostructure has slight effect on the species of Fe and the crystal phase of the products. The degree of Al(III) substituting Si(IV) in the tetrahedral sheets of the minerals obviously increased with increasing of Al doping levels. For the samples with low Al doping levels (5% and 10%), the adsorption capacity of the iron muscovite nanoparticles for Cd(II) increased slightly. With increasing of Al doping ratio to 15%, the obtained iron muscovite nanoparticles exhibited a maximal uptake of 41.4 mg g-1 for Cd(II), which is about two times that of the undoped samples (22.8 mg g-1). The solution pH had a slight effect on the Cd (II) capture at a wide pH range from 4 to 8. The adsorption of Cd(II) is very fast and reached a steady state within 5 min. Desorption results showed that the binding strength between Cd(II) and iron muscovite nanoparticles was obviously enhanced by incorporation of Al at a high level. The ion exchange and surface complexation are principal mechanisms in the Cd(II) capture by the iron muscovite nanomaterials with various structural Al species.

3.
J Cell Mol Med ; 2019 Sep 10.
Artigo em Inglês | MEDLINE | ID: mdl-31507078

RESUMO

The injury and dysfunction of the femoral head microvascular endothelial cells are associated with the pathogenesis of glucocorticoid-induced osteonecrosis of the femoral head (ONFH). Reports indicate that icariin (ICA) can enhance vascular roles and also inhibit endothelial cell dysfunction. However, it still remains unclear whether ICA can promote angiogenesis in glucocorticoid-induced ONFH. In this study, we investigate this hypothesis through in vitro and in vivo experiments. Results showed that 0.1 mg/mL hydrocortisone significantly suppressed bone microvascular endothelial cells (BMECs) proliferation while ICA at 10-5  mol/L reversed this inhibition. ICA significantly promoted BMECs migration, tube formation, the angiogenesis-related cytokines expression and the activation of Akt. Furthermore, ICA enhanced Bcl-2 expression but diminished Bax expression. According to in vivo results, rats with ICA treatment exhibited a lower ratio of empty lacunae, higher volume of blood vessels and more CD31-positive cells. This study revealed that ICA promotes angiogenesis of BMECs in vitro and improves femoral head blood vessel volume of rats treated with glucocorticoid, suggesting the efficacy of ICA in the prevention of glucocorticoid-induced ONFH.

4.
Clin Cardiol ; 2019 Sep 11.
Artigo em Inglês | MEDLINE | ID: mdl-31509271

RESUMO

BACKGROUND: In-hospital cardiac arrest (IHCA) may be preventable, with patients often showing signs of physiological deterioration before an event. Our objective was to develop and validate a simple clinical prediction model to identify the IHCA risk among cardiac arrest (CA) patients hospitalized with acute coronary syndrome (ACS). HYPOTHESIS: A predicting model could help to identify the risk of IHCA among patients admitted with ACS. METHODS: We conducted a case-control study and analyzed 21 337 adult ACS patients, of whom 164 had experienced CA. Vital signs, demographic, and laboratory data were extracted from the electronic health record. Decision tree analysis was applied with 10-fold cross-validation to predict the risk of IHCA. RESULTS: The decision tree analysis detected seven explanatory variables, and the variables' importance is as follows: VitalPAC Early Warning Score (ViEWS), fatal arrhythmia, Killip class, cardiac troponin I, blood urea nitrogen, age, and diabetes. The development decision tree model demonstrated a sensitivity of 0.762, a specificity of 0.882, and an area under the receiver operating characteristic curve (AUC) of 0.844 (95% CI, 0.805 to 0.849). A 10-fold cross-validated risk estimate was 0.198, while the optimism-corrected AUC was 0.823 (95% CI, 0.786 to 0.860). CONCLUSIONS: We have developed and internally validated a good discrimination decision tree model to predict the risk of IHCA. This simple prediction model may provide healthcare workers with a practical bedside tool and could positively impact decision-making with regard to deteriorating patients with ACS.

5.
J Biol Chem ; 2019 Sep 09.
Artigo em Inglês | MEDLINE | ID: mdl-31501242

RESUMO

Fungi of the genus Trichoderma are a rich source of enzymes, such as cellulases and hemicellulases, that can degrade lignocellulosic biomass and are therefore of interest for biotechnological approaches seeking to optimize biofuel production. The essential transcription factor ACE3 is involved in cellulase production in Trichoderma reesei; however, the mechanism by which ACE3 regulates cellulase activities is unknown. Here, we discovered that the nominal ace3 sequence in the T. reesei genome available through the Joint Genome Institute is erroneously annotated. Moreover, we identified the complete ace3 sequence, the ACE3 Zn(II)2Cys6 domain, and the ACE3 DNA-binding sites containing a 5'-CGGAN(T/A)3-3' consensus. We found that in addition to its essential role in cellulase production, ace3 is required for lactose assimilation and metabolism in T. reesei Transcriptional profiling with RNA-Seq revealed that ace3 deletion down-regulates not only the bulk of the major cellulase, hemicellulase, and related transcription factor genes, but also reduces the expression of lactose metabolism-related genes. Additionally, we demonstrate that ACE3 binds the promoters of many cellulase genes, the cellulose response transporter gene crt1, and transcription factor-encoding genes, including xyr1 We also observed that XYR1 dimerizes to facilitate cellulase production and that ACE3 interacts with XYR1. Together, these findings uncover how two essential transcriptional activators mediate cellulase gene expression in T. reesei On the basis of these observations, we propose a model of how the interactions between ACE3, Crt1, and XYR1 control cellulase expression and lactose metabolism in T. reesei.

6.
Artigo em Inglês | MEDLINE | ID: mdl-31495492

RESUMO

BACKGROUND: Bladder cancer (BCa) is one of the most common urological malignancies. While Inositol-3-phosphate synthase 1 (ISYNA1) expression and function were largely unknown in BCa. We aimed to study the expression and role of ISYNA1 in bladder cancer and investigate its potential mechanisms via ingenuity pathway analysis (IPA). METHODS: ISYNA1 expression was quantified by qRT-PCR in bladder cancer cell lines as well as normal urothelial cell line. Knocking down ISYNA1 gene in BCa T24 cells was achieved by shRNA lentivirus transfection. MTT and Celigo assay were used to assess cell proliferation. Flow cytometry was applied to test cell cycle and apoptosis. In addition, IPA was performed using PrimeView™ Human Gene Expression Array. Imunohistochemistry (IHC) was performed in BCa patient tissue microarray to verify the association between ISYNA1 expression and patients' clinicopathological features. RESULTS: ISYNA1 was significantly upregulated in BCa samples vs. para-tumor tissues. Higher expression were significantly associated with tumor T stage and lymph node metastasis of bladder cancer patients. Similarly, it was elevated in BCa cell lines (5637 and T24) compared with SVHUC cells. Knocking down ISYNA1 significantly decreased proliferation, induced apoptosis and cell cycle arrest in T24 cells. Furthermore, IPA indicated that ISYNA1 was an important regulatory factors and related networks were involved in multiple functional processes. CONCLUSION: Taken together, current study suggest ISYNA1 promotes proliferation and inhibit apoptosis in bladder cancer cells, and its expression correlated with BCa patients' clinicopathological features. Thus, ISYNA1 may serve as a potential biomarker and therapeutic target for BCa patients.

7.
Chem Asian J ; 2019 Aug 09.
Artigo em Inglês | MEDLINE | ID: mdl-31397073

RESUMO

Dye molecules pre-anchored on titanium oxo clusters (dye-TOCs) are attractive as model compounds of dye-sensitized titanium oxide. To investigate the effects of the dye ligand structures of the dye-TOCs on photocurrent conversion, a series of dye-TOCs with the same Ti6 core structure and different antenna ligands (L) was synthesized and characterized crystallographically. The TOCs have the same structural formula of [Ti6 O4 L2 (O3 PPh)2 (OiPr)10 ]. Two types of dyes with para- or meta-substituted structures were designed and used as the ligands. The results show that charge transfer from the donor group to the TiO core of the TOCs with the para-substituted ligands is stronger than those with the meta-substituted ligands. The steric effect of the ligands also greatly influences the photocurrent density. Larger branched structures of the dye ligands reduce the coverage density of the dye-TOCs on TiO2 electrodes and also weaken the effective covalent bonding of the dye-TOCs on the electrode, and consequently, the photocurrent is decreased.

8.
Int J Biol Macromol ; 139: 896-903, 2019 Aug 07.
Artigo em Inglês | MEDLINE | ID: mdl-31400416

RESUMO

Polysaccharides and flavan-3-ols from Cabernet Sauvignon wine were isolated and then characterized by high performance liquid chromatography coupled with diode array detector (HPLC-DAD), high performance size exclusion chromatography (HPSEC) and HPLC-MS. The influence of purified polysaccharides on the aggregation of flavan-3-ols-proteins were investigated using fluorescence spectroscopy, circular dichroism (CD) and sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) to evaluate the co-effect of polysaccharides on wine astringency. The results indicated that mannoproteins (MPs) and rhamnogalacturonans II (RG II) were the major polysaccharides to significantly alter the interaction of flavan-3-ols with bovine serum albumin (BSA). The interaction of polysaccharides-flavan-3-ols-BSA was enhanced with the concentration (from 0.2 to 0.6 g/L) of the studied polysaccharides. Furthermore, the reaction of BSA-flavan-3-ols was strengthened in the absence of polysaccharides when percentage of galloylation (%G) was higher (11.29). When mean degree of polymerization (mDP) of flavan-3-ols was from 5.14 to 6.88, the secondary structure of proteins was changed from mainly α-helix to random curl and the formation of protein precipitation increased. This work pointed out that the important property of polysaccharides and different structural characteristic flavan-3-ols are able to modulate wine astringency perception.

9.
ACS Appl Mater Interfaces ; 11(34): 31009-31017, 2019 Aug 28.
Artigo em Inglês | MEDLINE | ID: mdl-31368295

RESUMO

Thermal conversion of CO2 to value-added chemicals is challenging due to the extreme inertness of the CO2 molecule and the low selectivity of products. We reported a defect-rich MgH2/CuxO hydrogen storage composite from mechanochemical ball-milling for the catalytic hydrogenation of CO2 to lower olefins. The defect-rich MgH2/CuxO hydrogen storage composite achieves a C2=-C4= selectivity of 54.8% and a CO2 conversion of 20.7% at 350 °C under a low H2/CO2 ratio of 1:5, which increases the efficiency of H2 utilization by offering lattice H- species for hydrogenation. Density functional theory calculations show that the defective structure of MgH2/CuxO can promote CO2 molecule adsorption and activation, while the electronic structure of MgH2 is beneficial for offering lattice H- for CO2 molecule hydrogenation. The lattice H- can combine the C site of CO2 molecule to promote the formation of Mg formate, which can be further hydrogenated to lower olefins under a low H- concentration. This work for CO2 conversion by a defect-rich MgH2/CuxO hydrogen storage composite can inspire the catalysts design for the hydrogenation of CO2 to lower olefins.

10.
J Orthop Surg Res ; 14(1): 283, 2019 Aug 29.
Artigo em Inglês | MEDLINE | ID: mdl-31464637

RESUMO

BACKGROUND: During primary total knee arthroplasty (TKA), synovectomy as a part of the procedure has been recommended to relieve pain and inflammation of the synovium, but there is a controversy about it due to increased bleeding. In this meta-analysis, the aim is to answer whether synovectomy should be performed routinely during TKA for symptomatic knee osteoarthritis (KOA). METHODS: Relevant randomized controlled trials (RCTs) on synovectomy were retrieved through database searches of PubMed, Embase, Web of Science, and Cochrane Library up to February 2019. Studies that compared postoperative pain, clinical Knee Society Score (KSS), functional KSS, range of motion (ROM), drainage, pre- and postoperative hemoglobin difference, transfusion rate, operative time, and/or complications were included in the meta-analysis. Review Manager 5.3.0 was used for meta-analysis. RESULTS: We included 5 RCTs with 542 knees. Pooled results indicated that the synovectomy group was associated with more blood loss via drainage (WMD = - 99.41, 95% CI - 153.75 to - 45.08, P = 0.0003) and pre- and postoperative hemoglobin difference (WMD = - 0.93, 95% CI - 1.33 to - 0.5, P < 0.00001), compared with the non-synovectomy group. No statistically significant differences were demonstrated between both groups in postoperative pain, clinical KSS, functional KSS, ROM, transfusion rate, or complications (P > 0.05). CONCLUSIONS: The current evidence demonstrates that performing synovectomy in primary TKA for symptomatic KOA does not have any clinical benefit. It increases postsurgical blood loss. Surgeons routinely undertaking synovectomy should deliberate whether this is clinically indicated and consider limiting resection, if possible.

11.
Brain Res Bull ; 153: 1-7, 2019 Jul 29.
Artigo em Inglês | MEDLINE | ID: mdl-31369829

RESUMO

The study aimed to explore the molecular mechanism of fluoxetine as an adjunct to therapeutic exercise to improve motor recovery using a rat cerebral ischemic model with middle cerebral artery occlusion (MCAO). We hypothesized that the nucleus accumbens (NAc) may be one of the responding areas to fluoxetine where relevant elevations in 5-hydroxytryptamine (5-HT) and ΔFosB were associated with motor behavioral recovery. Male Sprague-Dawley rats were randomly divided into five groups: rats without intervention; rats that underwent MCAO without exercise or fluoxetine; rats that underwent MCAO treated only with fluoxetine; rats that underwent MCAO treated only with exercise; and rats that underwent MCAO treated with both exercise and fluoxetine. Motor function and motivation were assessed by the fault footsteps test and the forced swimming test. 5-HT level in the bilateral NAc and the expression of 5-HT2C receptor (5-HT2CR) and ΔFosB in the ipsilesional (left) NAc were measured. Correlation was explored by Pearson correlation analysis. Our results indicated that either treatment helped improve the grasp dexterity of the affected limb, motor motivation, and resilience to adverse environment in MCAO rats. The dual treatment with fluoxetine and exercise may hasten the recovery process. The dual treatment helped restore the balance of 5-HT level between the bilateral NAc by significantly increasing its level in the ipsilesional side. Either treatment could resume the expression of 5-HT2CR in the ipsilesional side of the NAc close to the normal level, which was correlated with motor recovery. The dual treatment significantly increased the expression of ΔFosB in the ipsilesional side of the NAc, which was correlated with the balance of 5-HT in the bilateral NAc, but not directly with motor recovery. In conclusion, the NAc may play an important role in driving physical motivation, which was possibly related to motor recovery after stroke. Fluoxetine may hasten the effectiveness of therapeutic exercise, possibly via regulating 5-HT and its receptors in the NAc.

12.
Opt Lett ; 44(16): 3988-3991, 2019 Aug 15.
Artigo em Inglês | MEDLINE | ID: mdl-31415529

RESUMO

We report a broadband optical parametric oscillator (OPO) pumped by a Yb-doped fiber laser system. By utilizing a 300 µm long magnesium-doped periodically poled LiNbO3 crystal as the parametric gain medium and configuring the OPO as a chirped-pulse oscillator, we obtained mid-infrared emission having an instantaneous bandwidth covering 3084-4466 nm. This result represents, to the best of our knowledge, the widest instantaneous bandwidth obtained from a Yb-fiber-laser-pumped singly resonant OPO, demonstrating the immense potential of chirped-pulse oscillation in scaling the instantaneous bandwidth of ultra-fast OPOs. Moreover, we performed a numerical simulation of chirped-pulse OPOs (CPOPOs) and revealed that the spectral profile of the output from a CPOPO was relevant to both the parametric gain profile of the nonlinear crystal and the intra-cavity high-order dispersion.

13.
J Exp Bot ; 2019 Jul 31.
Artigo em Inglês | MEDLINE | ID: mdl-31365744

RESUMO

Plant-parasitic nematodes secrete numerous effectors to facilitate parasitism, but detailed functions of nematode effectors and their plant targets remain largely unknown. Here, we characterized four macrophage migration inhibitory factors in Meloidogyne incognita resembling the MIFs secreted by human and animal parasites. Transcriptional data showed MiMIFs are upregulated in parasitism. Immunolocalization provided evidence that MiMIF proteins are secreted from the nematode hypodermis to the parasite surface, detected in plant tissues and giant cells. In plantaMiMIFs RNA interference in Arabidopsis decrease infection and nematode reproduction. Transient expression of MiMIF-2 could suppress Bax and RBP1/Gpa2 induced cell death. MiMIF-2 ectopic expression led to higher levels of Arabidopsis susceptibility, suppressed immune responses triggered by flg22 and impaired [Ca2+]cyt influx induced by H2O2. The immunoprecipitation of MiMIF-2-interacting proteins, followed by Co-IP and BiFC validations, revealed specific interactions between MiMIF-2 and two Arabidopsis annexins, AnnAt1 and AnnAt4, involved in the transport of calcium ions, stress responses and signal transduction. Suppression of expression or overexpression of these annexins modified nematode infection. Our results provide functional evidence that nematode effectors secreted from hypodermis to the parasite cuticle surface target host proteins and M. incognita uses MiMIFs to promote parasitism by interfering with the annexin-mediated plant immune responses.

15.
Infect Immun ; 87(9)2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31262980

RESUMO

Pneumonia due to Gram-negative bacteria is associated with high mortality. Acinetobacter baumannii is a Gram-negative bacterium that is associated with hospital-acquired and ventilator-associated pneumonia. Bacteria have been described to release outer membrane vesicles (OMVs) that are capable of mediating systemic inflammation. The mechanism by which A. baumannii OMVs mediate inflammation is not fully defined. We sought to investigate the roles that Toll-like receptors (TLRs) play in A. baumannii OMV-mediated pulmonary inflammation. We isolated OMVs from A. baumannii cultures and intranasally introduced the OMVs into mice. Intranasal introduction of A. baumannii OMVs mediated pulmonary inflammation, which is associated with neutrophil recruitment and weight loss. In addition, A. baumannii OMVs increased the release of several chemokines and cytokines in the mouse lungs. The proinflammatory responses were partially inhibited in TLR2- and TLR4-deficient mice compared to those of wild-type mice. This study highlights the important roles of TLRs in A. baumannii OMV-induced pulmonary inflammation in vivo.

16.
Stem Cell Res ; 39: 101501, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31344652

RESUMO

GA binding protein (GABP) is a ubiquitously expressed transcription factor that regulates the development of multiple cell types, including osteoblast, hematopoietic stem cells, B cells and T cells. However, so little is known about its biological function in the development of central nervous system. In this report, we show that GABP is highly expressed in neural stem/progenitor cells (NSPCs) and down-regulated in neurons, and that GABPß1 is required for the proper proliferation of NSPCs. Knockdown of GABPα resulted in an elevated expression level of GABPß1, and GABPß1 down-regulation significantly decreased the proliferation of NSPCs, whereas GABPß2 knockdown did not result in any changes in the proliferation of NSPCs. We observed that there was nearly a 21-fold increase of the GABPß1S mRNA level in GABPß1L KO NSPCs compared to WT cells, and knocking down of GABPß1S in GABPß1L KO NSPCs could further reduce their proliferation potential. We also found that knockdown of GABPß1 promoted neuronal and astrocytic differentiation of NSPCs. Finally, we identified dozens of downstream target genes of GABPß1, which are closely associated with the cell proliferation and differentiation. Collectively, our results suggest that both GABPß1L and GABPß1S play an essential role in regulating the proper proliferation and differentiation of NSPCs.

17.
Nat Commun ; 10(1): 3319, 2019 Jul 25.
Artigo em Inglês | MEDLINE | ID: mdl-31346162

RESUMO

Chromosome 17q21-ter is commonly gained in neuroblastoma, but it is unclear which gene in the region is important for tumorigenesis. The JMJD6 gene at 17q21-ter activates gene transcription. Here we show that JMJD6 forms protein complexes with N-Myc and BRD4, and is important for E2F2, N-Myc and c-Myc transcription. Knocking down JMJD6 reduces neuroblastoma cell proliferation and survival in vitro and tumor progression in mice, and high levels of JMJD6 expression in human neuroblastoma tissues independently predict poor patient prognosis. In addition, JMJD6 gene is associated with transcriptional super-enhancers. Combination therapy with the CDK7/super-enhancer inhibitor THZ1 and the histone deacetylase inhibitor panobinostat synergistically reduces JMJD6, E2F2, N-Myc, c-Myc expression, induces apoptosis in vitro and leads to neuroblastoma tumor regression in mice, which are significantly reversed by forced JMJD6 over-expression. Our findings therefore identify JMJD6 as a neuroblastoma tumorigenesis factor, and the combination therapy as a treatment strategy.

18.
J Craniofac Surg ; 30(5): e450-e453, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31299811

RESUMO

Chest wall ulcer induced by postmastectomy radiation therapy (PRMT) remains challenging for plastic surgeons because of the reduced blood supply, fibrosis, and impaired cellular potential in the irradiated area. In this study, chest wall ulcer was treated with negative pressure wound therapy (NPWT) and the latissimus dorsi myocutaneous (LDM) flap reconstruction in 2 stages. A retrospective study was performed on consecutive patients with chronic radiation-induced ulcers in chest wall from June 2012 to June 2017. Surgical debridement and NPWT were performed in the first stage and the chest wall reconstructed by the LDM flap transplantation after extensive debridement in the second stage. There were 10 female patients with chest wall ulcers with a mean age of 60.3 years. The average duration of the ulcers was 21.2 months and the ulcers varied from 1 × 2 to 5 × 7 cm. Histological examination denied any recurrent breast cancer or radiation-related malignancy. Negative pressure wound therapy was applied with 100 to 125 mm Hg negative pressure during a period of 5 to 7 days in the first stage. The LDM flap varied from 11 × 15 to 15 × 20 cm. The mean follow-up was 25.9 months. All the flaps survived well with satisfactory appearance and there was no donor-site morbidity or ulcer recurrence during the follow-up period. The staged treatment of the chest wall radiation ulcer incorporated the benefits of NPWT and LDM flap. It is beneficial in increasing the blood and nutrient supply to the irradiated tissue, enhancing the debridement and promoting tissue healing, thus improving the flap survival and decreasing the ulcer recurrence.

19.
Inorg Chem ; 58(14): 9246-9252, 2019 Jul 15.
Artigo em Inglês | MEDLINE | ID: mdl-31268320

RESUMO

Model studies on dye sensitized titanium oxides have attracted wide interest with respect to their importance in understanding photoelectric and photophysical processes. Ligand modified titanium oxo clusters (TOCs) have been considered as the most appropriate models for dye sensitized solar cells (DSSCs) on the basis of their atomically precise structures. However, the ligands used previously in TOC models were seldom the dyes that really applied in DSSCs due to the difficulty with which the crystals of the dye anchored TOCs are obtained. We report herein a series of TOCs with the popularly used arylamine-cyanoacrylate dyes. As the closest model of DSSCs, the TOCs were studied by DFT calculations based on their accurate structural information. They have also been applied to photoelectric conversion evaluation by a solar cell device. Both the theoretical and application results showed that the synergistic effect of intradye molecular charge transfer (ICT) and dye to TiO cluster charge transfer (LMCT) is important in increasing the power conversion efficiency.

20.
J Mol Cell Biol ; 2019 Jul 10.
Artigo em Inglês | MEDLINE | ID: mdl-31291646

RESUMO

High-throughput sequencing has facilitated the identification of many types of non-coding RNAs (ncRNAs) involved in diverse cellular processes. NcRNAs as epigenetic mediators play key roles in neuronal development, maintenance, and dysfunction by controlling gene expression at multiple levels. NcRNAs may not only target specific DNA or RNA for gene silence, but may also directly interact with chromatin-modifying proteins like Polycomb group (PcG) proteins to drive orchestrated transcriptional programs. Recent significant progress has been made in characterizing ncRNAs and PcG proteins involved in transcriptional, post-transcriptional, and epigenetic regulation. More importantly, dysregulation of ncRNAs, PcG proteins and interplay among them is closely associated with the pathogenesis of central nervous system (CNS) disorders. In this review, we focus on the interplay between ncRNAs and PcG proteins in CNS, and highlight the functional roles of the partnership during neural development and diseases.

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