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1.
Signal Transduct Target Ther ; 7(1): 7, 2022 01 04.
Artigo em Inglês | MEDLINE | ID: mdl-34983926

RESUMO

Activation-induced cytidine deaminase (AID) initiates class-switch recombination and somatic hypermutation (SHM) in antibody genes. Protein expression and activity are tightly controlled by various mechanisms. However, it remains unknown whether a signal from the extracellular environment directly affects the AID activity in the nucleus where it works. Here, we demonstrated that a deubiquitinase USP10, which specifically stabilizes nuclear AID protein, can translocate into the nucleus after AKT-mediated phosphorylation at its T674 within the NLS domain. Interestingly, the signals from BCR and TLR1/2 synergistically promoted this phosphorylation. The deficiency of USP10 in B cells significantly decreased AID protein levels, subsequently reducing neutralizing antibody production after immunization with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or human immunodeficiency virus type 1 (HIV-1) nanoparticle vaccines. Collectively, we demonstrated that USP10 functions as an integrator for both BCR and TLR signals and directly regulates nuclear AID activity. Its manipulation could be used for the development of vaccines and adjuvants.


Assuntos
Vacinas contra a AIDS/imunologia , Fator Ativador de Células B/imunologia , Vacinas contra COVID-19/imunologia , Citidina Desaminase/imunologia , HIV-1/imunologia , Nanopartículas , SARS-CoV-2/imunologia , Transdução de Sinais/imunologia , Ubiquitina Tiolesterase/imunologia , Ubiquitinação/imunologia , Vacinas contra a AIDS/genética , Animais , Fator Ativador de Células B/genética , Vacinas contra COVID-19/genética , Citidina Desaminase/genética , Células HEK293 , HIV-1/genética , Humanos , Camundongos , Camundongos Knockout , SARS-CoV-2/genética , Transdução de Sinais/genética , Ubiquitina Tiolesterase/genética
2.
Blood ; 2022 Jan 07.
Artigo em Inglês | MEDLINE | ID: mdl-34995350

RESUMO

Prophylactic high-dose methotrexate (HD-MTX) is often used for diffuse large B-cell lymphoma (DLBCL) patients at high risk of central nervous system (CNS) relapse, despite limited evidence demonstrating efficacy or the optimal delivery method. We conducted a retrospective, international analysis of 1,384 patients receiving HD-MTX CNS prophylaxis either intercalated (i-HD-MTX) (n=749) or at the end (n=635) of R-CHOP/R-CHOP-like therapy (EOT). There were 78 CNS relapses (3-year rate 5.7%), with no difference between i-HD-MTX and EOT; 5.7% vs 5.8%, p=0.98, 3-year difference: 0.04% (-2.0% to 3.1%). Conclusions were unchanged on adjusting for baseline prognostic factors or on 6-month landmark analysis (n=1,253). In patients with high CNS international prognostic index (n=600), 3-year CNS relapse rate was 9.1% with no difference between i-HD-MTX and EOT. On multivariable analysis, increasing age and renal/adrenal involvement were the only independent risk factors for CNS relapse. Concurrent intrathecal prophylaxis was not associated with reduction in CNS relapse. R-CHOP delays of ≥7 days were significantly increased with i-HD-MTX versus EOT, with 308/1573 (19.6%) i-HD-MTX treatments resulting in delay to subsequent R-CHOP (median 8 days). Increased risk of delay occurred in older patients when delivery was later than day 10 in the R-CHOP cycle. In summary, we found no evidence that EOT delivery increases CNS relapse risk versus i-HD-MTX. Findings in high-risk subgroups were unchanged. Rates of CNS relapse in this HD-MTX-treated cohort were similar to comparable cohorts receiving infrequent CNS prophylaxis. If HD-MTX is still considered for certain high-risk patients, delivery could be deferred until R-CHOP completion.

3.
Artigo em Inglês | MEDLINE | ID: mdl-34985600

RESUMO

Using a sample of 1338 families from 12 cultural groups in 9 nations, we examined whether retrospectively remembered Generation 1 (G1) parent rejecting behaviors were passed to Generation 2 (G2 parents), whether such intergenerational transmission led to higher Generation 3 (G3 child) externalizing and internalizing behavior at age 13, and whether such intergenerational transmission could be interrupted by parent participation in parenting programs or family income increases of > 5%. Utilizing structural equation modeling, we found that the intergenerational transmission of parent rejection that is linked with higher child externalizing and internalizing problems occurs across cultural contexts. However, the magnitude of transmission is greater in cultures with higher normative levels of parent rejection. Parenting program participation broke this intergenerational cycle in fathers from cultures high in normative parent rejection. Income increases appear to break this intergenerational cycle in mothers from most cultures, regardless of normative levels of parent rejection. These results tentatively suggest that bolstering protective factors such as parenting program participation, income supplementation, and (in cultures high in normative parent rejection) legislative changes and other population-wide positive parenting information campaigns aimed at changing cultural parenting norms may be effective in breaking intergenerational cycles of maladaptive parenting and improving child mental health across multiple generations.

4.
Food Chem ; 372: 131142, 2022 Mar 15.
Artigo em Inglês | MEDLINE | ID: mdl-34600193

RESUMO

To determine the glutathione (GSH) content in vegetables, an "on-off-on" fluorescence probe was developed by a synthesis of nitrogen and sulfur co-doped carbon dots (N,S-CDs) using the microwave pyrolysis considering citric acid and L-cysteine as precursors. The fluorescence of N,S-CDs was quenched by adding Cu2+ at a concentration of 20-200 µmol/L due to the inner filter effect. The quenched fluorescence of N,S-CDs@Cu2+ system was recovered by adding the GSH at a concentration of 10-150 µmol/L due to the sulfhydryl-metal compound mechanism. By observing the GSH concentrations measured by our N,S-CDs@Cu2+ system vs. a traditional fluorescent chelating method, the two measurements provided the GSH data with a good consistence by showing the RSD range of 1.86%-2.27%. This indicates the validation and novelty of our N,S-CDs@Cu2+ system as being a powerful fluorescent probe for effectively and efficiently determining the GSH in vegetables.


Assuntos
Glutationa , Pontos Quânticos , Carbono , Corantes Fluorescentes , Nitrogênio , Espectrometria de Fluorescência , Enxofre , Verduras
5.
Sci Total Environ ; 804: 150133, 2022 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-34509847

RESUMO

As one of the important components of PM2.5, elemental carbon (EC) particles could quickly mix with other organic or inorganic species after entering the atmosphere, which directly affected its climate and environmental effects and impact on human health. In order to study the mixture and evolution of EC particles in the atmosphere, this study used single particle aerosol mass spectrometry to measure the EC-containing particles in three winters (2016/17, 2018/19 and 2019/20) in Chengdu, one of the most polluted megacities in China. The results showed that the average mass concentrations of PM2.5 in the three winters were 121 ± 58 µg m-3, 90 ± 32 µg m-3 and 79 ± 38 µg m-3, respectively, and the mass ratios of PM2.5/PM10 were 0.71, 0.78 and 0.78, respectively. EC-containing particles accounted for 40.7%-54.7% of all particles and could be divided into six categories: EC-dust (EC-D), fresh EC (ECf), EC-organic carbon (EC-OC), EC-nitrate (EC-N), EC-sulfate (EC-S) and EC-sulfate-nitrate (EC-SN). From winter 2016/17 to 2019/20, the contributions of EC-N and EC-OC particles increased, while the contributions of EC-S and EC-SN particles decreased. Meanwhile, EC-N particles became increasingly important for the formation of heavy pollution. Photochemical and liquid-phase processes dominated the formation of EC-N and EC-S particles, respectively, while the dominant formation mechanism of EC-SN particles changed from photochemical to liquid-phase processes from winter 2016/17 to 2019/20. Total EC and EC-S particles in Chengdu were mainly transported from the east and southeast areas to Chengdu, while ECf particles mainly derived from local emissions. Compared with the previous two winters, the potential source areas of the EC-containing particles in winter 2019/20 reduced significantly. These findings provide new insight into the atmospheric behavior of urban particles and are important reference for the study of EC particles in other regions in the world, especially in urban areas.


Assuntos
Poluentes Atmosféricos , Material Particulado , Aerossóis/análise , Poluentes Atmosféricos/análise , Atmosfera , Carbono/análise , China , Monitoramento Ambiental , Humanos , Tamanho da Partícula , Material Particulado/análise , Estações do Ano
6.
World J Clin Cases ; 9(31): 9598-9606, 2021 Nov 06.
Artigo em Inglês | MEDLINE | ID: mdl-34877296

RESUMO

BACKGROUND: Spinal extradural arachnoid cysts (SEACs) are a rare cause of spinal cord compression. Typically, these cysts communicate with the intradural subarachnoid space through a small defect in the dural sac. For symptomatic SEACs, the standard treatment is to remove the cyst in total with a (hemi)laminectomy or laminoplasty. We present a rare case of bi-segmental non-communicating SEACs and describe our experience of using an endoscopic minimal access technique to remove bi-segmental non-communicating SEACs. CASE SUMMARY: A 79-year-old female presented with pain related to bi-segmental SEACs at the T11-L1 segments. She underwent sequential transforaminal percutaneous endoscopic thoracic cystectomy of the SEACs. Following her first procedure, spinal magnetic resonance imaging demonstrated complete excision of the cyst at the T12-L1 segment. However, the cyst at the T11-T12 segment was still present. Thus, a second procedure was performed to remove this lesion. The patient's right-sided lumbar and abdominal pain improved significantly postoperatively. Her Japanese Orthopaedic Association score increased from 11 to 25, her visual analogue scale score was reduced from 8 to 1. The physical and mental component summary of the 36-item short-form health survey (SF-36) were 15.5 and 34.375 preoperatively, and had increased to 79.75 and 77.275 at the last follow-up visit, respectively. CONCLUSION: Bi-segmental non-communicating SEACs are extremely rare. Endoscopic surgery is a safe, effective, and reliable method for treating these cysts. In the event of bi-segmental SEACs, it is important to identify whether both cysts are communicating before surgery, and if not, to remove both cysts separately during the index surgery to avoid re-operation.

7.
J Youth Dev ; 16(2-3): 379-401, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34888590

RESUMO

The current cross-cultural study aimed to extend research on parenting and children's prosocial behavior by examining relations among parental warmth, values related to family obligations (i.e., children's support to and respect for their parents, siblings, and extended family), and prosocial behavior during the transition to adolescence (from ages 9 to 12). Mothers, fathers, and their children (N = 1107 families) from 8 countries including 11 cultural groups (Colombia; Rome and Naples, Italy; Jordan; Kenya; the Philippines; Sweden; Thailand; and African Americans, European Americans, and Latin Americans in the United States) provided data over 3 years in 3 waves (Mage of child in wave 1 = 9.34 years, SD = 0.75; 50.5% female). Overall, across all 11 cultural groups, multivariate change score analysis revealed positive associations among the change rates of parental warmth, values related to family obligations, and prosocial behavior during late childhood (from age 9 to 10) and early-adolescence (from age 10 to 12). In most cultural groups, more parental warmth at ages 9 and 10 predicted steeper mean-level increases in prosocial behavior in subsequent years. The findings highlight the prominent role of positive family context, characterized by warm relationships and shared prosocial values, in fostering children's positive development in the transition to adolescence. The practical implications of these findings are discussed.

8.
Food Chem ; : 131666, 2021 Nov 25.
Artigo em Inglês | MEDLINE | ID: mdl-34848090

RESUMO

An optical detection platform based on laser induced spectroscopy and double integrating spheres techniques was developed to obtain absorption (µa), reduced scattering coefficients (µ's) and fluorescence intensity of oil. The validation experiment carried on liquid phantoms showed that the developed system could achieve high linearity, and the results of spectra analysis indicated that the fluorescence intensity has a significant negative correlation with both µa and µ's. A total of 1620 oils with six categories were detected. The reason for the difference of fluorescence and µa spectra was analyzed by comparing the measured chlorophyll, polyphenol and α-tocopherol contents. Linear discriminant analysis combined with principal component analysis based on fluorescence and µa spectra was employed, to calibrate the AFB1 classification models. The discrimination results manifested that by integrating µa with fluorescence signal, the correct classification rate could be improved by more than 10%, and the false negative rate was greatly reduced.

9.
Ecotoxicol Environ Saf ; 229: 113059, 2021 Dec 08.
Artigo em Inglês | MEDLINE | ID: mdl-34894427

RESUMO

Perfluorinated compounds are emerging organic pollutants widely used in building materials, textiles, and electric equipment. Herein, silico analysis was conducted using bioinformatics approach to assess the potential relationship between bladder cancer and perfluorinated compounds. Transcriptome profiles and data of perfluorinated compounds were obtained from The Cancer Genome Atlas (TCGA) and the Genotype-Tissue Expression and Comparative Toxicogenomics databases. Gene Ontology (GO9 and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses showed that interactive genes were mainly enriched in bladder cancer (BC). Transcriptome profiles were used to verify the expression of m6A-related genes at the mRNA and protein levels. Most m6A-related genes predicted BC prognosis. Survival analysis and ROC curves demonstrated that the expression levels of m6A-related genes were associated with BC prognosis. Perfluorooctanoic acid (PFOA) significantly increased the cell proliferation ability and promoted cell invasion capacity. In addition, PFOA significantly increased the cell viability and cell invasion capacity of T24 and BIU-87 cell lines compared with the control group. Taken together, these results show that perfluorinated compounds could promote BC progression. DATA AVAILABILITY: Data and materials are available within the manuscript.

10.
Front Microbiol ; 12: 758889, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34899642

RESUMO

The mechanism of bacterial adaption to manganese-polluted environments was explored using 50 manganese-tolerant strains of bacteria isolated from soil of the largest manganese mine in China. Efficiency of manganese removal by the isolated strains was investigated using atomic absorption spectrophotometry. Bacillus safensis strain ST7 was the most effective manganese-oxidizing bacteria among the tested isolates, achieving up to 82% removal at a Mn(II) concentration of 2,200 mg/L. Bacteria-mediated manganese oxide precipitates and high motility were observed, and the growth of strain ST7 was inhibited while its biofilm formation was promoted by the presence of Mn(II). In addition, strain ST7 could grow in the presence of high concentrations of Al(III), Cr(VI), and Fe(III). Genome-wide analysis of the gene expression profile of strain ST7 using the RNA-seq method revealed that 2,580 genes were differently expressed under Mn(II) exposure, and there were more downregulated genes (n = 2,021) than upregulated genes (n = 559) induced by Mn stress. KAAS analysis indicated that these differently expressed genes were mainly enriched in material metabolisms, cellular processes, organism systems, and genetic and environmental information processing pathways. A total of twenty-six genes from the transcriptome of strain ST7 were involved in lignocellulosic degradation. Furthermore, after 15 genes were knocked out by homologous recombination technology, it was observed that the transporters, multicopper oxidase, and proteins involved in sporulation and flagellogenesis contributed to the removal of Mn(II) in strain ST7. In summary, B. safensis ST7 adapted to Mn exposure by changing its metabolism, upregulating cation transporters, inhibiting sporulation and flagellogenesis, and activating an alternative stress-related sigB pathway. This bacterial strain could potentially be used to restore soil polluted by multiple heavy metals and is a candidate to support the consolidated bioprocessing community.

11.
Mach Learn Med Imaging ; 12966: 615-623, 2021 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-34927174

RESUMO

Skull segmentation from three-dimensional (3D) cone-beam computed tomography (CBCT) images is critical for the diagnosis and treatment planning of the patients with craniomaxillofacial (CMF) deformities. Convolutional neural network (CNN)-based methods are currently dominating volumetric image segmentation, but these methods suffer from the limited GPU memory and the large image size (e.g., 512 × 512 × 448). Typical ad-hoc strategies, such as down-sampling or patch cropping, will degrade segmentation accuracy due to insufficient capturing of local fine details or global contextual information. Other methods such as Global-Local Networks (GLNet) are focusing on the improvement of neural networks, aiming to combine the local details and the global contextual information in a GPU memory-efficient manner. However, all these methods are operating on regular grids, which are computationally inefficient for volumetric image segmentation. In this work, we propose a novel VoxelRend-based network (VR-U-Net) by combining a memory-efficient variant of 3D U-Net with a voxel-based rendering (VoxelRend) module that refines local details via voxel-based predictions on non-regular grids. Establishing on relatively coarse feature maps, the VoxelRend module achieves significant improvement of segmentation accuracy with a fraction of GPU memory consumption. We evaluate our proposed VR-U-Net in the skull segmentation task on a high-resolution CBCT dataset collected from local hospitals. Experimental results show that the proposed VR-U-Net yields high-quality segmentation results in a memory-efficient manner, highlighting the practical value of our method.

12.
Artigo em Inglês | MEDLINE | ID: mdl-34927176

RESUMO

Virtual orthognathic surgical planning involves simulating surgical corrections of jaw deformities on 3D facial bony shape models. Due to the lack of necessary guidance, the planning procedure is highly experience-dependent and the planning results are often suboptimal. A reference facial bony shape model representing normal anatomies can provide an objective guidance to improve planning accuracy. Therefore, we propose a self-supervised deep framework to automatically estimate reference facial bony shape models. Our framework is an end-to-end trainable network, consisting of a simulator and a corrector. In the training stage, the simulator maps jaw deformities of a patient bone to a normal bone to generate a simulated deformed bone. The corrector then restores the simulated deformed bone back to normal. In the inference stage, the trained corrector is applied to generate a patient-specific normal-looking reference bone from a real deformed bone. The proposed framework was evaluated using a clinical dataset and compared with a state-of-the-art method that is based on a supervised point-cloud network. Experimental results show that the estimated shape models given by our approach are clinically acceptable and significantly more accurate than that of the competing method.

13.
Eur J Ophthalmol ; : 11206721211065218, 2021 Dec 17.
Artigo em Inglês | MEDLINE | ID: mdl-34918576

RESUMO

BACKGROUND: There are no systematic reviews yet that evaluated the effects of PE/IA in patients with optic neuritis (ON) in demyelinating diseases. A meta-analysis of available study is needed to further explore the value of plasma exchange (PE) or immunoadsorption (IA) in treating ON in demyelinating diseases. METHODS: All relevant articles published on PubMed, Web of Science, Cochrane Library, Embase, China National Knowledge Infrastructure (CNKI), VIP Database, Wanfang, Sinomed and ophthalmology professional websites were searched. Study characteristics, demographic characteristics, clinical features and outcome measures were extracted. Response rate, adverse events (AE) rate, serious adverse event (SAE) rate, the log of the minimum angle of resolution (logMAR), visual outcome scale (VOS) and expanded disability status scales (EDSS) were evaluated using a random-effects model. RESULTS: 35 studies were included between 1985 and 2020, containing 1191 patients. The response rates of PE and IA in acute attack of ON were 68% and 82% respectively. LogMAR (-0.60 to - 1.42) and VOS (-1.10 to -1.82) had been significantly improved from within 1 month to more than 1 month after PE treatment. Besides, we found that logMAR improved 1.78, 0.95 and 0.38, respectively ,when the time from symptom onset to the first PE/IA was less than 21 days, 21-28 days, and more than 28 days. The pooled mean difference of EDSS was -1.14.Adverse effects rate in patients with PE or IA were 0.20 and 0.06, respectively. CONCLUSION: The meta-analysis provided evidence that PE/IA treatment was an effective and safe intervention, and it is recommended that early initiation of PE/IA treatment is critical.

14.
Radiother Oncol ; 167: 195-202, 2021 Dec 27.
Artigo em Inglês | MEDLINE | ID: mdl-34968471

RESUMO

BACKGROUND AND PURPOSE: The preoperative lymph node (LN) status is important for the treatment of colorectal cancer (CRC). Here, we established and validated a deep learning (DPL) model for predicting lymph node metastasis (LNM) in CRC. MATERIALS AND METHODS: A total of 423 CRC patients were divided into cohort 1 (training set, n = 238, testing set, n = 101) and cohort 2 (validation set, n = 84). Among them, 84 patients' tumour tissues were collected for RNA sequencing. The DPL features were extracted from enhanced venous-phase computed tomography of CRC using an autoencoder. A DPL model was constructed with the least absolute shrinkage and selection operator algorithm. Carcinoembryonic antigen and carbohydrate antigen 19-9 were incorporated into the DPL model to construct a combined model. The model performance was assessed by receiver operating characteristic curves, calibration curves and decision curves. The correlations between DPL features, which have been selected, and genes were analysed by Spearman' correlation, and the genes correlated with DPL features were used to transcriptomic analysis. RESULTS: The DPL model, integrated with 20 DPL features, showed a good discrimination performance in predicting the LNM, with areas under the curves (AUCs) of 0.79, 0.73 and 0.70 in the training set, testing set and validation set, respectively. The combined model had a better performance, with AUCs of 0.81, 0.77 and 0.73 in the three sets, respectively. Decision curve analysis confirmed the clinical application value of the DPL model and combined model. Furthermore, catabolic processes and immune-related pathways were identified and related with the selected DPL features. CONCLUSION: This study presented a DPL model and a combined model for LNM prediction. We explored the potential genomic phenotypes related with DPL features. In addition, the model could potentially be utilized to facilitate the individualized prediction of LNM in CRC.

15.
Sci Total Environ ; 814: 152572, 2021 Dec 23.
Artigo em Inglês | MEDLINE | ID: mdl-34954175

RESUMO

Upon environmental weathering, plastic materials form smaller sized microplastics, of which the contamination in agricultural fields is of significant importance and increasing social concern. Plastic mulch films are considered a major source of agricultural soil microplastic pollution. However, the mechanism and kinetics of microplastic formation from plastic mulch films were rarely understood. In this study, the rate of microplastic generation from typical mulch films, such as oxodegradable, biodegradable, and conventional non-degradable (polyethylene, PE) mulch films, were quantified in soil under simulated UV irradiation. Results showed that microplastic formation was more rapid from biodegradable mulch film, followed sequentially by oxodegradable mulch film, white PE mulch film, and black PE mulch film. The kinetics of microplastic generation strictly followed the Schwarzchild's law, with exponential growth at indexes between 1.6309 and 2.0502 in the microplastic generation model. At a cumulative UV irradiation of 2.1 MJ/m2, the average quantity of microplastics released from biodegradable, oxodegradable, and white and black non-degradable mulch films were 475, 266, 163, 147 particles/cm2, respectively; with particle sizes largely distributed within 0.02-0.10 mm range. Concurrent increase in crystallinity and surface erosion of the mulch films were observed upon UV irradiation, which further determined the accessibility and activity of the materials to photo-oxidation (reflected as HI indexes), therefore played a critical role on the quantity and size ranges of microplastic debris.

16.
Mach Learn Med Imaging ; 12966: 606-614, 2021 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-34964046

RESUMO

Accurate bone segmentation and landmark detection are two essential preparation tasks in computer-aided surgical planning for patients with craniomaxillofacial (CMF) deformities. Surgeons typically have to complete the two tasks manually, spending ~12 hours for each set of CBCT or ~5 hours for CT. To tackle these problems, we propose a multi-stage coarse-to-fine CNN-based framework, called SkullEngine, for high-resolution segmentation and large-scale landmark detection through a collaborative, integrated, and scalable JSD model and three segmentation and landmark detection refinement models. We evaluated our framework on a clinical dataset consisting of 170 CBCT/CT images for the task of segmenting 2 bones (midface and mandible) and detecting 175 clinically common landmarks on bones, teeth, and soft tissues. Experimental results show that SkullEngine significantly improves segmentation quality, especially in regions where the bone is thin. In addition, SkullEngine also efficiently and accurately detect all of the 175 landmarks. Both tasks were completed simultaneously within 3 minutes regardless of CBCT or CT with high segmentation quality. Currently, SkullEngine has been integrated into a clinical workflow to further evaluate its clinical efficiency.

17.
Artigo em Inglês | MEDLINE | ID: mdl-34966912

RESUMO

Facial appearance changes with the movements of bony segments in orthognathic surgery of patients with craniomaxillofacial (CMF) deformities. Conventional bio-mechanical methods, such as finite element modeling (FEM), for simulating such changes, are labor intensive and computationally expensive, preventing them from being used in clinical settings. To overcome these limitations, we propose a deep learning framework to predict post-operative facial changes. Specifically, FC-Net, a facial appearance change simulation network, is developed to predict the point displacement vectors associated with a facial point cloud. FC-Net learns the point displacements of a pre-operative facial point cloud from the bony movement vectors between pre-operative and simulated post-operative bony models. FC-Net is a weakly-supervised point displacement network trained using paired data with strict point-to-point correspondence. To preserve the topology of the facial model during point transform, we employ a local-point-transform loss to constrain the local movements of points. Experimental results on real patient data reveal that the proposed framework can predict post-operative facial appearance changes remarkably faster than a state-of-the-art FEM method with comparable prediction accuracy.

18.
Curr Med Sci ; 41(6): 1178-1186, 2021 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-34918176

RESUMO

Stent implantation has been proven to be safe and has become the first-line intervention for May-Thurner syndrome (MTS), with satisfactory mid-term patency rates and clinical outcomes. Recent research has demonstrated that catheter-directed thrombolysis is the preferred strategy when MTS is combined with deep vein thrombosis after self-expanding stent placement. However, the stent used for the venous system was developed based on the experience obtained in the treatment of arterial disease. Consequently, relatively common corresponding complications may come along later, which include stent displacement, deformation, and obstruction. Different measures such as adopting a stent with a larger diameter, improving stent flexibility, and increasing stent strength have been employed in order to prevent these complications. The ideal venous stent is presently being evaluated and will be introduced in detail in this review.

19.
J Environ Pathol Toxicol Oncol ; 40(4): 73-85, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34936302

RESUMO

BACKGROUND: Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-related death. However, the molecular mechanism of its pathogenesis is still unclear. This study analyzed the pathophysiology of HCC based on the perspective of lncRNAs and mRNAs expression to find effective diagnostic strategies and prognostic markers. METHODS: Data for HCC patients and normal controls were downloaded from the GEO and TCGA databases. LncRNAs and mRNAs differentially expressed in HCC patients were screened by R language (3.6.0). The ROC curves of the ten lncRNAs with the most significant expression differences were drawn, and survival analysis was conducted. Then, the differentially expressed mRNAs were annotated by using GO and KEGG databases. The protein-protein interactions in the lncRNA-mRNA coexpression network were analyzed with the STRING database. Tissue and cell experiments were performed to verify the results of bioinformatics analysis. RESULTS: A large number of differentially expressed lncRNAs and mRNAs in HCC were correlated. Four lncRNAs were significantly associated with the prognosis of HCC patients. These differentially expressed lncRNAs mainly regulated the proliferation and lipid metabolism of HCC. Cell experiments confirmed that lnc-MMADHC-5 could inhibit the development of HCC. CONCLUSION: lncRNAs regulated the proliferation and lipid metabolism of HCC. Lnc-APBB1-1, lnc-FBXO42-1, lnc-JAKMIP2-1, and lnc-MMADHC-5 might be prognostic markers for HCC. Lnc-MMADHC-5 could inhibit the development of HCC.


Assuntos
Carcinoma Hepatocelular/genética , Regulação Neoplásica da Expressão Gênica , Neoplasias Hepáticas/genética , MicroRNAs/genética , RNA Longo não Codificante/genética , Carcinoma Hepatocelular/metabolismo , Perfilação da Expressão Gênica , Neoplasias Hepáticas/metabolismo , MicroRNAs/metabolismo , RNA Longo não Codificante/metabolismo , Análise de Sobrevida
20.
Dev Psychopathol ; : 1-16, 2021 Dec 13.
Artigo em Inglês | MEDLINE | ID: mdl-34895387

RESUMO

Prior to the COVID-19 pandemic, adolescents (N = 1,330; Mages = 15 and 16; 50% female), mothers, and fathers from nine countries (China, Colombia, Italy, Jordan, Kenya, Philippines, Sweden, Thailand, United States) reported on adolescents' internalizing and externalizing problems, adolescents completed a lab-based task to assess tendency for risk-taking, and adolescents reported on their well-being. During the pandemic, participants (Mage = 20) reported on changes in their internalizing, externalizing, and substance use compared to before the pandemic. Across countries, adolescents' internalizing problems pre-pandemic predicted increased internalizing during the pandemic, and poorer well-being pre-pandemic predicted increased externalizing and substance use during the pandemic. Other relations varied across countries, and some were moderated by confidence in the government's handling of the pandemic, gender, and parents' education.

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