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1.
Sci Rep ; 7(1): 9772, 2017 08 29.
Artigo em Inglês | MEDLINE | ID: mdl-28852170

RESUMO

To investigate the concentrations of rare earth elements in cereals and assess human health risk through cereal consumption, a total of 327 cereal samples were collected from rare earth mining area and control area in Shandong, China. The contents of 14 rare earth elements were determined by Inductively Coupled Plasma-Mass Spectrometry (ICP-MS). The medians of total rare earth elements in cereals from mining and control areas were 74.22 µg/kg and 47.83 µg/kg, respectively, and the difference was statistically significant (P < 0.05). The wheat had the highest rare earth elements concentrations (109.39 µg/kg and 77.96 µg/kg for mining and control areas, respectively) and maize had the lowest rare earth elements concentrations (42.88 µg/kg and 30.25 µg/kg for mining and control areas, respectively). The rare earth elements distribution patterns for both areas were characterized by enrichment of light rare earth elements. The health risk assessment demonstrated that the estimated daily intakes of rare earth elements through cereal consumption were considerably lower than the acceptable daily intake (70 µg/kg bw). The damage to adults can be neglected, but more attention should be paid to the effects of continuous exposure to rare earth elements on children.


Assuntos
Grão Comestível/química , Meio Ambiente , Metais Terras Raras/análise , Mineração , Medição de Risco , China , Humanos
2.
Ann Hum Biol ; 43(5): 469-79, 2016 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-26382012

RESUMO

BACKGROUND: Recently the G-105A promoter polymorphism in SEPS1 has been shown to increase pro-inflammatory cytokine expression and, thus, to be correlated with various types of human cancers and diseases. AIMS: This study examined whether this functional polymorphism was related to the risks of several human diseases by performing a meta-analysis. SUBJECTS AND METHODS: This study identified all published studies in MEDLINE, Science Citation Index, the Cochrane Library, PubMed, Embase, Current Contents Index and three Chinese databases. RESULTS AND CONCLUSIONS: Eleven case-control studies were incorporated into this meta-analysis. The results showed that carriers of the rs28665122 G > A polymorphism in the SEPS1 gene are at increased risk of developing diseases under five genetic models. According to the ethnicity-stratified sub-group analysis, SEPS1 rs28665122 polymorphism is significantly linked to increased risk of developing related diseases in Europeans under five genetic models; but not among Asians. This data indicates a statistical association between SEPS1 rs28665122 G > A variants and the development of various human diseases. Such findings suggest that SEPS1 may be a potential gene marker for disease diagnosis and prognosis.


Assuntos
Doença/genética , Predisposição Genética para Doença , Proteínas de Membrana/genética , Polimorfismo de Nucleotídeo Único/genética , Selenoproteínas/genética , Alelos , Bases de Dados como Assunto , Estudos de Associação Genética , Humanos , Modelos Genéticos , Análise Multivariada , Viés de Publicação , Análise de Regressão , Fatores de Risco
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