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1.
J Colloid Interface Sci ; 606(Pt 2): 1627-1635, 2022 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-34500164

RESUMO

Poor cycling stability and low volumetric capacity of sulfur cathode prevents practical application of Lithium-sulfur (Li-S) batteries. Herein, we demonstrate a strategy to address the two drawbacks of sulfur cathode by synthesizing a compact and flexible film cathode with bilayer structure using a two-step vacuum filtration method. Two layers make up the sulfur cathode, active layer (sulfur-acethlene black (SC) spheres) and barrier layer (three dimensional MnO2-graphene oxide-multi-walled carbon nanotubes (MnO2-GO-CNTs) composites), which are integrated together by reduced graphene oxide (rGO) through self-binding. The rGO sheets provide an electrical conductive framework and a stable architecture to accommodate volume changes of sulfur. SC spheres stacked orderly between the rGO layers facilitate fast Li+ storage and energy release. Polar MnO2-GO-CNTs composites with large specific surface area have not only afforded efficient sites for chemically binding polysulfides, but also provided fast electron transfer for accelerating polysulfides redox reaction. Consequently, the integrated film cathode exhibits an unprecedented cycling stability of ~0.0279% capacity decay per cycle over more than 600 cycles at 1C and high volumetric capacity of 1021.9 Ah L-1 at 2C. Meanwhile, a foldable Li-S battery based on this flexible cathode is fabricated and shows excellent mechanical and electrochemical properties. The integrated flexible sulfur cathode of this study sheds light on the design strategies for application in flexible high volumetric capacity system.

2.
Food Chem ; 369: 130891, 2022 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-34507089

RESUMO

High-density lipoprotein (HDL) was extracted from hen eggs and enzymatic hydrolysates were formed by neutral protease, trypsin and alkaline protease, which were named as EHN, EHT and EHA, respectively. The solubility of hydrolysates was significantly higher than that of HDL, especially that of EHA significantly increased from 7.69% to 27.54% when it was hydrolyzed for 1.5 h. The emulsifying properties of EHT, EHA and EHN exhibited an increase trend as a function of hydrolysis time and reached the peak values at 3.5, 1.5 and 3.5 h, respectively. This improvement was attributed to the generation of soluble peptides fragments and the exposure of ionizable residues. At different pH, temperatures and ionic strengths, the stability of emulsions stabilized by hydrolysates was higher than that of HDL, especially for emulsions prepared by EHT. These findings might indicate feasible guidance to broaden the application of HDL and enzymatic hydrolysates in emulsions.


Assuntos
Gema de Ovo , Lipoproteínas HDL , Animais , Galinhas , Emulsões , Feminino , Hidrólise , Hidrolisados de Proteína
3.
Sci Total Environ ; 802: 149729, 2022 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-34454135

RESUMO

Atmospheric heavy metal deposition in agroecosystems has increased recently, especially in northern China, which poses serious risks to crop safety and human health via food chain. Wheat grains can accumulate high levels of Pb even when wheat is planted in soils with low levels of Pb. However, the influence of atmospheric deposition on the accumulation and distribution of Pb in wheat grain is still unclear. A field survey was conducted in three districts (A: a district with industrial and traffic pollution; B: a district with traffic pollution; and C: an unpolluted district) in Hebei Province, North China. The grain of wheat cultivated in district A accumulated more Pb from soil and atmospheric deposition than those in other districts, and the bran from district A contained 3.50 and 2.04 times more Pb than those from districts B and C, respectively. The Pb distribution pattern in wheat grain detected by laser ablation inductively coupled mass spectrometry (LA-ICP-MS) was characterized by accumulation mostly in the pericarp and seed coat rather than in the crease, embryo and endosperm. Furthermore, Pb isotopic data showed that airborne Pb was the major source (>50%) of Pb in wheat grain. Interestingly, average contributions of Pb from atmospheric deposition to white flour (78.22%) were higher than its contributions to bran (56.27%). In addition, wheat flag leaves were exposed to PbSO4 at the booting stage, and much greater Pb accumulation (0.33-0.48 mg/kg) was observed in exposed wheat grain than in the control (P < 0.05), PbSO4 constituted most (82.80-100%) of the Pb in the wheat grain. In summary, the results confirmed the efficient foliar Pb uptake and transfer from atmospheric deposition into wheat grain. It would be a new sight for understanding the contribution of airborne Pb to Pb accumulation in wheat grains.


Assuntos
Terapia a Laser , Metais Pesados , Poluentes do Solo , China , Grão Comestível/química , Monitoramento Ambiental , Humanos , Chumbo , Espectrometria de Massas , Solo , Poluentes do Solo/análise , Triticum
4.
Methods Mol Biol ; 2349: 41-64, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-34718990

RESUMO

Integral membrane proteins are embedded in biological membranes where various lipids modulate their structure and function. There exists a critical need to elucidate how these lipids participate in the physiological and pathological processes associated with the membrane protein dysfunction. Native mass spectrometry (MS), combined with ion mobility spectrometry (IM), is emerging as a powerful tool to probe membrane protein complexes and their interactions with ligands, lipids, and other small molecules. Unlike other biophysical approaches, native IM-MS can resolve individual ligand/lipid binding events. We have developed a novel method using native MS, coupled with a temperature-control apparatus, to determine the thermodynamic parameters of individual ligand or lipid binding events to proteins. This approach has been validated using several soluble protein-ligand systems wherein MS results are compared with those acquired from conventional biophysical techniques, such as isothermal titration calorimetry (ITC) and surface plasmon resonance (SPR). Using these principles, it is possible to elucidate the thermodynamics of individual lipid binding to integral membrane proteins. Herein, we use the ammonia channel (AmtB) from Escherichia coli as a model membrane protein. Remarkably, distinct thermodynamic signatures for AmtB binding to lipids with different headgroups and acyl chain configurations are observed. Additionally, using a mutant form of AmtB that abolishes a specific lipid binding site, distinct changes have been discovered in the thermodynamic signatures compared with the wild-type, implying that these signatures can identify key residues involved in specific lipid binding and potentially differentiate between specific lipid binding sites. This chapter provides procedures and findings associated with temperature-controlled native MS as a novel approach to interrogate membrane proteins and their interactions with lipids and other molecules.

5.
Energy (Oxf) ; 239: 122166, 2022 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-34608350

RESUMO

The COVID-19 pandemic affects all the aspects of modern society worldwide, especially in the power sector. Measures of flexibility enhancement are regarded as solutions to guarantee reliable and flexible electricity supply in such an emergency. This study aims at investigating the impact of flexibility enhancement measures (electricity storage and flexible demand) in different situations of the preliminary COVID-19 pandemic. Case studies in different regions (Denmark, the Netherlands, and the Sichuan province of China) are conducted and assessed using the hourly simulation tool EnergyPLAN. These regions own different electricity supply mix and level of renewable electricity. It is found that the flexible demand measure within one day or one week can hardly eliminate the electricity imbalance caused by either the pandemic or the increasing renewable electricity. The monthly flexible demand is effective for balancing, but its potential in these regions is not enough. However, electricity storage measure enhances the electricity balance even during the most extreme situation of the pandemic. From the economic perspective, electricity storage measure leads to an increase of up to 15% in total system costs, while flexible demand measure has a negligible effect on costs. This study serves as the first step to understand the performance of flexibility enhancement measures in the power sector under the shock of a pandemic.

6.
Sci Total Environ ; 806(Pt 4): 150962, 2022 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-34656593

RESUMO

The sensitivity of soil organic carbon (SOC) mineralization to temperature could affect the future atmospheric CO2 levels under global warming. Sieved soils are widely used to assess SOC mineralization and its temperature sensitivity (Q10) via laboratory incubation. However, sieved soils cause a temporary increase in mineralization due to the destruction of soil structure, which can affect estimates of SOC mineralization, especially in soils managed with no-till (NT). To identify the effects of soil sieving on SOC mineralization and Q10, soil was collected from an 11-year field experiment under a wheat-maize cropping system managed with a combination of tillage [NT and plow tillage (PT)] and residue [residue returning (RR) and residue removal (R0)]. Soil was either sieved or left in an undisturbed state and incubated at 15 °C and 25 °C. SOC mineralization in sieved soils at 25 °C was 47.28 g C kg-1 SOC, 160.1% higher than SOC mineralization in undisturbed soils (P < 0.05). Interestingly, Q10 values in sieved soils were 1.29, 77.6% lower than Q10 in undisturbed soils (P < 0.05). Highly significant correlations (P < 0.01) were observed between sieved and undisturbed soils for SOC mineralization (r = 0.85-0.98) and Q10 (r = 0.78-0.87). Soil macro-aggregates had lower SOC mineralization by 6.1-21.9%, but higher Q10 values by 4.7-6.5% compared with micro-aggregates, contributing to lower mineralization and higher Q10 under NT and RR. Furthermore, structure equation and random forest modelling showed that increased SOC contents in NT and RR could not only reduce SOC mineralization, but also constrained the improvement of Q10 in NT and RR. Overall, these results indicated that although sieved soils overestimated SOC mineralization and underestimated Q10 due to the destruction of macro-aggregates, the patterns between treatments were similar and sieving soil for incubation is considered as a suitable approach to evaluate the relative impacts of NT and RR on SOC mineralization and Q10.

7.
J Affect Disord ; 297: 314-320, 2022 01 15.
Artigo em Inglês | MEDLINE | ID: mdl-34715184

RESUMO

BACKGROUND: The COVID-19 pandemic has brought a lot of working stress to medical workers and has a certain impact on their mental health. Working stress is closely related to the increase in anxiety, but few studies have explored whether their relationship will be affected by positive psychological factors in the special situation. METHODS: 798 medical workers were investigated online after the outbreak of the COVID-19 (10 February to 1 March 2020) in China. The relevant questionnaires were used to evaluate working stress, anxiety, sense of control, and psychological capital. The moderated mediation model test was performed using the SPSS software and PROCESS macro program. RESULTS: Working stress could directly affect anxiety, and indirectly affect anxiety through sense of control. In addition, psychological capital moderated the direct effect of working stress on anxiety, which is more effective at high level of psychological capital. Psychological capital also moderated the second half of the indirect effect of working stress on anxiety, at low level of psychological capital, sense of control was more effective in predicting anxiety. LIMITATIONS: All the data in this study was collected through online questionnaire. The anxiety response measured in this study cannot be specific to the viral epidemic. CONCLUSIONS: Under the COVID-19 epidemic situation, for medical workers, low sense of control and low level of psychological capital may be important risk factors of anxiety caused by working stress. Thus, strengthening the sense of control and psychological capital of medical workers would be helpful to reduce their anxiety and maintain their mental health.

8.
Food Chem ; 370: 130899, 2022 Feb 15.
Artigo em Inglês | MEDLINE | ID: mdl-34509149

RESUMO

The oil-in-water high internal phase emulsions (HIPEs) could be stabilized by pea protein isolate nanoparticles (PPINs) induced by potassium metabisulfite (K2S2O5). Confocal laser scanning microscope proved that PPINs were attached on the oil-water interface, indicating characteristic of Pickering HIPEs. The HIPEs stabilized by PPINs of higher concentration had smaller droplet size, better storage and centrifugal stability than that of PPINs of low concentration because there were enough particles to constitute the thick interface film. The storage modulus was higher than loss modulus indicating that HIPEs exhibited gel-like structure. At different temperatures and ionic strengths, HIPEs exhibited flocculation but still maintained a stable gel-like structure. The strain curve of HIPEs showed Type III nonlinear behavior due to the flocculation of emulsion droplets. HIPEs stabilized by PPINs might be a potential alternative to partially hydrogenated oils to reduce intake of trans fatty acids.


Assuntos
Nanopartículas , Proteínas de Ervilha , Emulsões , Concentração Osmolar , Tamanho da Partícula , Temperatura
9.
J Hazard Mater ; 421: 126794, 2022 01 05.
Artigo em Inglês | MEDLINE | ID: mdl-34365236

RESUMO

Conversion of digestate into biochar-based catalysts is an effective strategy for disposal and resource utilization. The active sites on biochar correlated with reactive species formation in peroxymonosulfate (PMS) system directly. Clarifying the structure-performance relationship of digestate derived biochar in PMS system was essential for decomposition of contaminants. Herein, dairy manure digestate derived biochar (DMDB) was prepared for PMS activation and sulfamethoxazole (SMX) degradation. The higher pyrolysis temperature could promote effective sites generation. Especially, the DMDB-800 catalyst exhibited excellent performance for PMS activation, achieving 90.2% degradation of SMX within 60 min. Based on the correlation analysis between log (k) values and active sites, defects, graphite N and CO were identified as dominant sites for PMS activation. The 1O2 oxidation and surface electron transfer were critical routes for SMX degradation. Besides, the degradation pathways of SMX were proposed according to DFT calculations and intermediates determination. The cleavage of the sulfonamide bond, hydroxylation of the benzene ring and oxidation of the amino group mainly occurred during SMX degradation. Overall, this study provides deep insights into the enhanced mechanism of tunable active sites on DMDBs for PMS activation, boosting the application of digestate biochar for water treatment in advanced oxidation systems.


Assuntos
Biocombustíveis , Peróxidos , Domínio Catalítico , Carvão Vegetal , Sulfanilamida
10.
Sci Total Environ ; 805: 150355, 2022 Jan 20.
Artigo em Inglês | MEDLINE | ID: mdl-34818767

RESUMO

Post COVID-19, mucormycosis occurred after the SARS-CoV-2 has rampaged the human population and is a scorching problem among the pandemic globally, particularly among Asian countries. Invasive mucormycosis has been extensively reported from mild to severe COVID-19 survivors. The robust predisposing factor seems to be uncontrolled diabetes mellitus, comorbidity and immunosuppression acquired through steroid therapy. The prime susceptive reason for the increase of mucormycosis cases is elevated iron levels in the serum of the COVID survivors. A panoramic understanding of the infection has been elucidated based on clinical manifestation, genetic and non- genetic mechanisms of steroid drug administration, biochemical pathways and immune modulated receptor associations. This review lime-lights and addresses the "What", "Why", "How" and "When" about the COVID-19 associated mucormycosis (CAM) in a comprehensive manner with a pure intention to bring about awareness to the common public as the cases are inevitably and exponentially increasing in India and global countries as well. The article also unearthed the pathogenesis of mucormycosis and its association with the COVID-19 sequela, the plausible routes of entry, diagnosis and counter remedies to keep the infection at bay. Cohorts of case reports were analysed to spotlight the link between the pandemic COVID-19 and the nightmare-mucormycosis.


Assuntos
COVID-19 , Mucormicose , Comorbidade , Fungos , Humanos , Mucormicose/epidemiologia , Pandemias , SARS-CoV-2
11.
Sci Total Environ ; 805: 150335, 2022 Jan 20.
Artigo em Inglês | MEDLINE | ID: mdl-34818777

RESUMO

Organic acids play an important role in metal tolerance, uptake, and translocation in hyperaccumulators. Phytolacca americana is a rare earth element (REE) hyperaccumulator, but the underlying mechanisms on REE tolerance and accumulation mediated by organic acids are poorly understood. Here, we reported for the first time the strategy of P. americana to enhance REE tolerance and accumulation through organic acids from root external secretion to internal biosynthesis. Different from the exclusion of heavy metal by organic acid in the typical plants, the results showed that oxalate secretion (0.3-0.6 µmol h-1 g-1 root DW) induced by yttrium (Y) could not prevent Y from entering the roots, resulting in excess Y uptake by P. americana. Yttrium stress also stimulated the accumulation of malate and citrate by 1.4- and 2.0-folds in the root cortex. Exogenous malate and citrate promoted the redistribution of Y from the root cell walls to the shoot by 30% and 21%, respectively. Based on comparative transcriptome analysis, 6-fold up-regulation was observed in PaNIP1;2, whose homology AtNIP1;2 is responsible for the transport of Al-malate in Arabidopsis. These results suggested that the promoted formation of Y-malate complexes within the roots potentially accelerated the transport of Y from P. americana roots to shoots through PaNIP1;2. Our study revealed the potential mechanism of organic acids in the external exclusion and internal detoxification and translocation of REE in P. americana roots, which provided a basis for improving the efficiency of REE phytoextraction.


Assuntos
Arabidopsis , Metais Terras Raras , Phytolacca americana , Compostos Orgânicos , Raízes de Plantas
12.
Environ Pollut ; 292(Pt B): 118482, 2022 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-34763020

RESUMO

Living in walkable neighborhoods has been reported to be associated with a lower risk of cardiovascular disease. Features of walkable neighborhoods, however, may be related to particulate matter with an aerodynamic diameter ≤2.5 µm (PM2.5), which could increase risk of cardiovascular disease. The interaction effect between walkability and PM2.5 on risk of ischemic stroke remains to be elucidated. In this study, we recruited a total of 27,375 participants aged ≥40 years from Yinzhou District, Ningbo, Zhejiang Province, China to investigate the associations of walkability and PM2.5 with risk of ischemic stroke. We used amenity categories and decay functions to evaluate walkability and high-spatiotemporal-resolution land-use regression models to assess PM2.5 concentrations. We used Cox proportional hazards regression models to calculate hazard ratios (HRs) and 95% confidence intervals (CIs). During a median follow-up of 4.08 years, we identified a total of 637 incident cases of ischemic stroke in the entire cohort. Higher walkability was associated with a lower risk of ischemic stroke (quartile, Q4 vs. Q1 walkability: HR = 0.59, 95% CI: 0.47-0.75), whereas PM2.5 was positively associated with risk of ischemic stroke (Q4 vs. Q1 PM2.5: HR = 1.70, 95% CI: 1.29-2.25). Furthermore, we observed a significant interaction between walkability and PM2.5 on risk of ischemic stroke. Walkability was inversely associated with risk of ischemic stroke at lower PM2.5 concentrations, but this association was attenuated with increasing PM2.5 concentrations. Although walkable neighborhoods appear to decrease the risk of ischemic stroke, benefits may be offset by adverse effects of PM2.5 exposure in the most polluted areas. These findings are meaningful for future neighborhood design, air pollution control, and stroke prevention.


Assuntos
Isquemia Encefálica , AVC Isquêmico , Acidente Vascular Cerebral , Isquemia Encefálica/epidemiologia , China/epidemiologia , Estudos de Coortes , Humanos , Material Particulado/análise , Estudos Prospectivos , Acidente Vascular Cerebral/epidemiologia
13.
BMC Anesthesiol ; 21(1): 298, 2021 Nov 30.
Artigo em Inglês | MEDLINE | ID: mdl-34847868

RESUMO

BACKGROUND: The spread of spinal anesthesia was influenced by many factors, and the effect of body height on spinal anesthesia is still arguable. This study aimed to explore the impact of height on the spread of spinal anesthesia and the stress response in parturients. METHODS: A total of ninety-seven parturients were allocated into two groups according to their height: the shorter group (body height was shorter than 158 cm) and taller group (body height was taller than 165 cm). Spinal anesthesia was performed with the same amount of 12 mg plain ropivacaine in mothers of different heights. The primary outcome of the study was the success or failure of the spinal anesthesia. The secondary outcomes of the study were stress response, time to T6 sensory level, the incidence of hypotension, the satisfaction of abdominal muscle relaxation and patient VAS scores. RESULTS: The rate of successful spinal anesthesia in the shorter group was significantly higher than that in the taller group (p = 0.02). The increase of maternal cortisol level in the shorter group was lower than that in the taller group at skin closure (p = 0.001). The incidence of hypotension (p = 0.013), time to T6 sensory block (p = 0.005), the quality of abdominal muscle relaxation (p <  0.001), and VAS values in stretching abdominal muscles and uterine exteriorization (p <  0.001) in the shorter group were significantly different from those in the taller group. Multivariate analysis showed that vertebral column length (p <  0.001), abdominal girth (p = 0.022), amniotic fluid index (p = 0.022) were significantly associated with successful spinal anesthesia. CONCLUSIONS: It's difficult to use a single factor to predict the spread of spinal anesthesia. Patient's vertebral column length, amniotic fluid index and abdominal girth were the high determinant factors for predicting the spread of spinal anesthesia. TRIALS REGISTRATION: ChiCTR-ROC-17012030 ( Chictr.org.cn ), registered on 18/07/2017.

14.
Environ Pollut ; : 118585, 2021 Nov 27.
Artigo em Inglês | MEDLINE | ID: mdl-34848290

RESUMO

Chinese cabbage (Brassica rapa ssp. pekinensis) is one of the most popular and frequently consumed leafy vegetables. It was found that atmospheric PM2.5-Pb contributes to Pb accumulation in the edible leaves of Chinese cabbage via stomata in North China during haze seasons with high concentrations of fine particulate matter in autumn and winter. However, it is unclear whether both stomata and trichomes co-regulate foliar transfer of PM2.5-Pb from atmospheric deposition to the leaf of Chinese cabbage genotypes with trichomes. Field and hydroponic experiments were conducted to investigate the effects of foliar uptake of PM2.5-Pb on Pb accumulation in leaves using two genotypes of Chinese cabbage, one without trichomes and one with trichomes. It was verified that open stoma is a prominent pathway of foliar PM2.5-Pb transfer in the short-term exposure for 6 h, contributing 74.5% of Pb accumulation in leaves, whereas Pb concentrations in the leaves of with-trichome genotype in the rosette stage were 6.52- and 1.04-fold higher than that of without-trichome genotype in greenhouse and open field, respectively, which suggests that stomata and trichomes co-regulate foliar Pb uptake of from atmospheric PM2.5. Moreover, subcellular Pb in the leaves was distributed in the following order of cytoplasm (53.8%) > cell wall (38.5%)> organelle (7.8%), as confirmed through high-resolution secondary ion mass spectrometry (NanoSIMS). The Leadmium™ Green AM dye manifested that Pb in PM2.5 entered cellular space of trichomes and accumulated in the basal compartment, enhancing foliar Pb uptake in the edible leaves of cabbage. The results of these experiments are evidence that both stomata and trichomes are important pathways in the regulation of foliar Pb uptake and translocation in Chinese cabbage.

15.
Cancer Manag Res ; 13: 8723-8736, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34849027

RESUMO

Objective: This study aimed to develop and validate a machine learning model for predicting bone metastases (BM) in prostate cancer (PCa) patients. Methods: Demographic and clinicopathologic variables of PCa patients in the Surveillance, Epidemiology and End Results (SEER) database from 2010 to 2017 were retrospectively analyzed. We used six different machine learning algorithms, including Decision tree (DT), Random forest (RF), Multilayer Perceptron (MLP), Logistic regression (LR), Naive Bayes classifiers (NBC), and eXtreme gradient boosting (XGB), to build prediction models. External validation using data from 644 PCa patients of the First Affiliated Hospital of Nanchang University from 2010 to 2016. The performance of the models was evaluated using the area under receiver operating characteristic curve (AUC), accuracy score, sensitivity (recall rate) and specificity. A web predictor was developed based on the best performance model. Results: A total of 207,137 PCa patients from SEER were included in this study. Of whom, 6725 (3.25%) developed BM. Gleason score, Prostate-specific antigen (PSA) value, T, N stage and age were found to be the risk factors of BM. The XGB model offered the best predictive performance among these 6 models (AUC: 0.962, accuracy: 0.884, sensitivity (recall rate): 0.906, and specificity: 0.879). An XGB model-based web predictor was developed to predict BM in PCa patients. Conclusion: This study developed a machine learning model and a web predictor for predicting the risk of BM in PCa patients, which may help physicians make personalized clinical decisions and treatment strategy for patients.

16.
Front Plant Sci ; 12: 730228, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34745163

RESUMO

High salinity causes ionic, osmotic, and oxidative stresses to plants, and the antioxidant enzyme Catalase2 (CAT2) plays a vital role in this process, while how CAT2 expression is regulated during plant response to high salinity remains elusive. Here, we report that phytohormone jasmonic acid (JA) impairs plant salt stress tolerance by repressing CAT2 expression in an MYC2-dependent manner. Exogenous JA application decreased plant salt stress tolerance while the jar1 mutant with reduced bioactive JA-Ile accumulation showed enhanced salt stress tolerance. JA enhanced salt-induced hydrogen peroxide (H2O2) accumulation, while treatment with H2O2-scavenger glutathione compromised such effects of JA on plant H2O2 accumulation and salt stress tolerance. In addition, JA repressed CAT2 expression in salt-stressed wild-type plant but not in myc2, a mutant of the master transcriptional factor MYC2 in JA signaling, therefore, the myc2 mutant exhibited increased salt stress tolerance. Further study showed that mutation of CAT2 largely reverted lower reactive oxygen species (ROS) accumulation, higher CAT activity, and enhanced salt stress tolerance of the myc2 mutant in myc2 cat2-1 double mutant, revealing that CAT2 functions downstream JA-MYC2 module in plant response to high salinity. Together, our study reveals that JA impairs Arabidopsis seedling salt stress tolerance through MYC2-mediated repression of CAT2 expression.

17.
Front Med (Lausanne) ; 8: 752556, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34746187

RESUMO

Objectives: Although acupuncture is often advocated for patients with rheumatoid arthritis (RA), its efficacy for type 2 diabetes mellitus (T2DM), a common metabolic disease among RA cohorts, has not yet been established. This retrospective cohort study aimed to determine the association between acupuncture use and the development of T2DM among them. Methods: Data were collected from 1999 through 2008 for individuals aged 20-70 years in the nationwide insurance database of Taiwan. From them, we extracted 4,941 subjects within newly diagnosed RA and being T2DM free at baseline. A total of 2,237 patients had ever received acupuncture, and 2,704 patients without receiving acupuncture were designated as a control group. All of them were followed to the end of 2013 to identify T2DM incidence. The Cox proportional hazards regression model was utilized to obtain the adjusted hazard ratio (HR) for acupuncture use. Results: Compared with the RA subjects without use of acupuncture, the incidence of T2DM was lower for those who received acupuncture, with the incidence rates of 24.50 and 18.00 per 1,000 person-years (PYs), respectively. After adjusting for potential confounders, use of acupuncture was significantly related to the lower T2DM risk, with the adjusted HR of 0.73 [95% confidence interval (CI) 0.65-0.86]. Those who used acupuncture for more than five sessions had the greatest benefit in lowering the susceptibility to T2DM. Conclusion: Adding acupuncture into conventional treatment for RA was found to be related to lower risk of T2DM among RA patients. Further clinical and mechanistic studies are warranted.

18.
Inorg Chem ; 2021 Nov 11.
Artigo em Inglês | MEDLINE | ID: mdl-34762802

RESUMO

Within Mn-activated phosphors, the oxidation state of Mn dopant strongly depends on the structural features of the host lattice. This paper reported a new polymorph of CsMg(PO3)3 (CMP) with a complicated three-dimensional (3D) framework of [Mg(PO3)3]∞ that is constructed by MgO6 octahedra and 1D infinite [PO3]∞ chains. Then we prepared a series of red phosphors CsMg1-x(PO3)3:xMn2+ (CMP:xMn2+) by high temperature solid state reactions in the open air. Powder X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and photoluminescence (PL) studies revealed the single Mn2+-oxidation. Under 404 nm light exciting, CMP:0.2Mn2+ can emit single-band emission at around 630 nm with full-width at half-maximum (fwhm) of 70 nm. Besides, CMP:0.2Mn2+ possesses excellent thermostability up to 450 K. These features indicate that CMP:0.2Mn2+ is suitable to be used for LED backlight display. Moreover, this work suggests that a host lattice with suitable structure feature can form single Mn2+-oxidation and is rigid enough to protect Mn2+ from being oxidized by O2 at high temperature.

19.
Mol Carcinog ; 2021 Nov 10.
Artigo em Inglês | MEDLINE | ID: mdl-34758156

RESUMO

To search for colorectal cancer (CRC) risk loci, Swedish samples were used for a genome-wide haplotype analysis. A logistic regression model was employed in 2663 CRC cases and 1642 controls in the discovery analysis. Three analyses were done, on all, familial-, and nonfamilial CRC samples and only results with odds ratio (OR) > 1 were analyzed. single nucleotide polymorphism (SNP) analysis did not generate any statistically significant results. Haplotype analysis suggested novel loci, on chromosome 2q36.1 (OR = 1.71, p value = 5.6924 × 10-8 ) in all CRC samples, chromosome 1q43 (OR = 4.04 p value = 3.24 × 10-8 ) in familial CRC samples, and two hits in nonfamilial CRC samples, chromosomes 2q36.1 (OR = 1.71 p value = 5.69 × 10-8 ) and 3p24.3 (OR = 1.62 p value = 6.21 × 10-9 ). Moreover, one locus on chromosome 20q13.33 was suggested in analyses of all samples, and five more novel loci were suggested on chromosomes 10q25.3, 15q,22.31, 17p11.2, 1p34.2, and 3q24. The haplotypes from the analysis of all samples were replicated in a second study of CRC cases and controls from the same part of Sweden. In summary, using haplotype analysis in Swedish CRC samples, the best hits were novel loci and the locus on chromosomes 2q36.1 and 20q13.33 suggested in the analysis of all samples were confirmed in a second cohort. The ORs were often higher than ORs from published genome-wide association study (GWAS). The study suggested it was possible that a risk locus could involve more than one gene, and that haplotypes could give information on the gene or genes possibly involved in the risk at specific locus.

20.
Artigo em Inglês | MEDLINE | ID: mdl-34797762

RESUMO

Video Anomaly detection in videos refers to the identification of events that do not conform to expected behavior. However, almost all existing methods cast this problem as the minimization of reconstruction errors of training data including only normal events, which may lead to self-reconstruction and cannot guarantee a larger reconstruction error for an abnormal event. In this paper, we propose to formulate the video anomaly detection problem within a regime of video prediction. We advocate that not all video prediction networks are suitable for video anomaly detection. Then, we introduce two principles for the design of video prediction network for video anomaly detection. Based on them, we elaborately design a video prediction network with appearance and motion constraints for video anomaly detection. Further, to promote the generalization of the prediction based video anomaly detection for novel scenes, we carefully investigate the usage of a meta learning within our framework, where our model can be fast adapted to a new testing scene with only a few staring frames. Extensive experiments on both a toy dataset and three real datasets validate the effectiveness of our method in terms of robustness to the uncertainty in normal events and the sensitivity to abnormal events.

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