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1.
Am J Cardiol ; 125(3): 475-481, 2020 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-31784053

RESUMO

Cardiac involvement in autoimmune diseases (AD) is common but underdiagnosed due to a lack of sensitive imaging methods. We aim to evaluate the characteristics of left ventricular (LV) systolic dysfunction in patients with AD using deformational parameters from 2-dimensional speckle-tracking echocardiography (STE). We retrospectively enrolled 86 AD patients and 71 healthy controls. All subjects underwent transthoracic echocardiography and STE to analyze LV strain and twist. A twist-radial displacement loop was constructed to investigate the relation between LV contractility and dimension. In AD patients, 68 had preserved LV ejection fraction (EF ≥ 50%), and 18 had reduced LVEF (EF < 50%). The patients with preserved LVEF exhibited significantly lower values of global longitudinal, circumferential, and radial strain than controls (-19.11 ± 4.18 vs -21.49 ± 2.53%, -25.17 ± 5.04% vs -27.37 ± 2.87%, 17.68 ± 5.69% vs 21.17 ± 6.44%, respectively; all p <0.01) and a marked attenuation in peak twist (14.24 ± 5.57 vs 18.10 ± 5.97, p <0.01) attributed to impaired apical rotation (9.03 ± 5.17 vs 12.79 ± 5.99, p <0.01). AD patients were more likely to present with abnormal loop types with flat ascending slope and delayed peak twist time. In conclusion, abnormal strain and twist precede deterioration in LVEF, suggesting early myocardial involvement in AD. STE can be used as a good alternative for early detection of myocardial dysfunction in AD patients.

2.
BMC Neurol ; 19(1): 266, 2019 Nov 04.
Artigo em Inglês | MEDLINE | ID: mdl-31684908

RESUMO

BACKGROUND: Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is an inflammatory disorder in the central nervous system (CNS) with distinct clinical, radiological, and pathological characteristics. The pathophysiology of CLIPPERS still remains unclear. Because a few cases about lymphoma mimicking the manifestations of CLIPPERS were reported and the prognosis of lymphoma is much worse, early identification of lymphoma is very important. CASE PRESENTATION: A 31-year-old woman was admitted with 3 months' history of diplopia, dizziness, gait ataxia, and right facial numbness. The diagnosis of CLIPPERS was established based on the finding of punctate enhancing lesions in the cerebellum, thalamus, pons, medulla, and midbrain region in magnetic resonance imaging (MRI), together with the favorable clinical and radiological responses to corticosteroids. However, she was diagnosed as peripheral T cell lymphoma, not otherwise specified (PTCL-NOS) by the pulmonary nodular and the skin biopsy almost 10 years later, and she got complete remission within 1 year after chemotherapy. CONCLUSION: We report the first case of CLIPPERS developing PTCL-NOS. This case proposes that when brain biopsy was difficult to achieve, biopsies in extra-cerebral lesions under the assisting examination of positron emission tomography-computed tomography (PET-CT) can be helpful in further identification.


Assuntos
Doenças do Sistema Nervoso Central , Inflamação , Linfoma de Células T Periférico , Adulto , Biópsia , Encéfalo/diagnóstico por imagem , Encéfalo/patologia , Encéfalo/fisiopatologia , Feminino , Humanos , Imagem por Ressonância Magnética , Esteroides/uso terapêutico
3.
Psychooncology ; 2019 Oct 26.
Artigo em Inglês | MEDLINE | ID: mdl-31654596

RESUMO

OBJECTIVES: This study aimed to examine the level of stigma and identify the correlates of stigma among lung cancer patients in China. METHODS: In total, 283 lung cancer patients were recruited from a tertiary cancer center in China by the convenience sampling method and completed a demographic, disease-related information and situational characteristics questionnaire and self-reported measures assessing stigma, state self-esteem, and coping self-efficacy. RESULTS: The mean stigma score was moderate (2.38 ± 0.45). Stigma was significantly and negatively associated with state self-esteem (r = -0.607, P < .001) and coping self-efficacy (r = -0.424, P < .001). Multivariable linear regression showed that age, cancer stage, negative changes (ie, in financial burden, body image, and family relationship), cancer disclosure, perceived blame, state self-esteem, and coping self-efficacy accounted for 49.9% of the variance in stigma. CONCLUSIONS: Stigma is a widespread psychosocial phenomenon among patients with lung cancer in China. Health care policy-makers and professionals should pay more attention to this issue and take effective measures to address stigma among lung cancer patients by improving their state self-esteem and coping self-efficacy, encouraging cancer disclosure and providing support for adjusting to negative changes after diagnosis.

4.
Int J Infect Dis ; 88: 141-148, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31442630

RESUMO

OBJECTIVES: The aim of this study was to investigate the efficacy of combination therapy of caspofungin and TMP/SMZ (trimethoprim/sulfamethoxazole) in moderate to severe pneumocystis jirovecii pneumonia (PJP) in patients without human immunodeficiency virus infection (HIV) and the relationship between therapeutic effect and plasma (1, 3) Beta-d-Glucan (BDG) levels. METHODS: We retrospectively reviewed HIV-negative patients with PJP diagnosed in our department, who were treated with combination therapy of caspofungin and TMP/SMZ or monotherapy of TMP/SMZ during a six and a half year period. RESULTS: A total of 126 moderate to severe PJP patients were enrolled in the study. In the multivariate analysis, low lymphocyte counts, high serum lactate dehydrogenase levels at the diagnosis of PJP and progression to shock were significant risk factors for death. In all patients, there was no significant difference in risk of death at 3 months. In the group of BDG≥800pg/m, patients receiving combination therapy was associated with a significantly decreased risk of death at 3 months, whereas in the group of BDG<800pg/ml, there were no statistically significant difference in survival rate between the two treatment regimens. CONCLUSION: High initial plasma (1, 3) Beta-d-Glucan concentration may be a predictor of satisfactory caspofungin response to HIV-negative patients with PJP. Based on our findings, we suggest the choice of combination therapy with caspofungin and TMP/SMZ as the initial treatment when BDG≥800pg/ml in moderate to severe HIV-negative patients with PJP.


Assuntos
Antifúngicos/uso terapêutico , Caspofungina/administração & dosagem , Pneumonia por Pneumocystis/tratamento farmacológico , Combinação Trimetoprima e Sulfametoxazol/uso terapêutico , beta-Glucanas/sangue , Adulto , Monitoramento de Medicamentos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Pneumocystis carinii/efeitos dos fármacos , Pneumocystis carinii/fisiologia , Pneumonia por Pneumocystis/sangue , Pneumonia por Pneumocystis/diagnóstico , Pneumonia por Pneumocystis/mortalidade , Estudos Retrospectivos , Fatores de Risco
5.
J Clin Neurosci ; 66: 156-164, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31088767

RESUMO

BACKGROUND: We studied patients with chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) associated with or without lymphoma and measured risk factors suggestive of an underlying lymphoma and follow-up outcomes. METHODS: CLIPPERS patients associated with or without lymphoma were included into this study. Clinical presentations were documented, risk factors suggestive of an underlying lymphoma were tested, and prognostic differences in terms of death were compared. RESULTS: Ten patients had a diagnosis of CLIPPERS associated with lymphoma, with 6 B-cell non-Hodgkin lymphoma, 2 T-cell non-Hodgkin lymphoma and 2 Hodgkin lymphoma. Using multivariate logistic analysis, the following 3 independent risk factors were found to be related to a final diagnosis of lymphoma: hyperreflexia (HR 16.56; 95% CI 1.03-265.29; p = 0.032), elevated protein in CSF (HR 11.59; 95% CI 1.24-108.39; p = 0.047), and recurrences between 2 months and 1 year after treatment (HR 29.27; 95% CI 2.09-409.58; p = 0.012). The model calibration was satisfactory (p = 0.392 with the Hosmer-Lemeshow test), and the discrimination power was good (area under the receiver operating characteristic curve 0.921; p < 0.001, 95% CI 0.826-1.000). Patients with CLIPPERS associated with lymphoma had higher mortality rate and lymphoma was a significant predictor of total mortality (HR 0.040; 95% CI 0.006-0.262; p = 0.001). CONCLUSIONS: Hyperreflexia, elevated protein in CSF and recurrences between 2 months and 1 year after treatment are risk factors suggesting an underlying lymphoma. Relapses during high-dose steroids maintenance therapy can be indicative of lymphoma, too. Patients having CLIPPERS associated with lymphoma have a worse prognosis than those without lymphoma.


Assuntos
Encefalopatias/diagnóstico , Linfoma/diagnóstico , Ponte/patologia , Adulto , Encefalopatias/tratamento farmacológico , Encefalopatias/etiologia , Feminino , Humanos , Inflamação , Linfoma/complicações , Imagem por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Ponte/diagnóstico por imagem , Esteroides/uso terapêutico
6.
Medicine (Baltimore) ; 98(4): e14201, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-30681592

RESUMO

RATIONALE: Concomitant cryoglobulinemic vasculitis and cold agglutinin disease (CAD) is an extremely uncommon clinical scenario. The role of bortezomib in the treatment of cryoglobulinemic vasculitis needs further investigation. PATIENT CONCERNS: A 72-year-old Chinese woman presented with a 25-year history of cyanosis of the extremities after cold exposure, which worsened and was accompanied with purpuric skin lesions and proteinuria in recent years. Laboratory data demonstrated hemolysis. Cold agglutinin and cryoglobulin tests were positive. There was no evidence for malignancies after blood, image, and pathologic tests. DIAGNOSES: Concomitant cryoglobulinemic vasculitis and CAD. INTERVENTIONS: The patient was treated with bortezomib-based regimen, including bortezomib, cyclophosphamide, and dexamethasone. OUTCOMES: The patient responded well to the treatment. Both symptoms and laboratory tests significantly improved. The patient's condition was in a state of sustained remission in the 6-month follow-up. LESSONS: This rare case promotes further understanding of these 2 diseases and suggests that bortezomib is a promising treatment in type I cryoglobulinemic vasculitis.


Assuntos
Anemia Hemolítica Autoimune/tratamento farmacológico , Bortezomib/uso terapêutico , Crioglobulinemia/tratamento farmacológico , Vasculite/tratamento farmacológico , Idoso , Anemia Hemolítica Autoimune/complicações , Crioglobulinemia/complicações , Ciclofosfamida/uso terapêutico , Dexametasona/uso terapêutico , Feminino , Humanos , Resultado do Tratamento , Vasculite/complicações
7.
J Thorac Dis ; 10(7): 4156-4168, 2018 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-30174860

RESUMO

Background: Differences in short-term and 1-year outcomes of percutaneous edge-to-edge mitral repair between patients with functional and degenerative mitral regurgitation (MR) remain unclear. We performed a systematic review and meta-analysis to investigate the safety and efficacy of MitraClip (MC) in patients with different MR etiologies. Methods: This study systematically searched three common databases for studies on MC therapy until November 2017. The studies meeting the standard inclusion criteria were included. The data at baseline, short-term and 1-year clinical and echocardiographic outcomes were obtained and analyzed. All data were checked by another reviewer. Results: Thirteen studies totalling 2,351 patients investigating the short-term and 1-year outcomes of MC in patients with functional MR (FMR) versus degenerative MR (DMR) were included for further analysis. FMR patients presented a higher risk profile at baseline. There was no difference in short-term outcomes between DMR and FMR for post-procedural MR grade 0-2 (76.8% vs. 77.1%; P=0.428), mean trans-mitral gradient (3.92 vs. 3.50 mmHg; P=0.098), 30-day mortality rate (0.05% vs. 0.03%; P=0.118) and 30-day NYHA I-II (85.3% vs. 78.7%; P=0.211). FMR patients had a higher rate of acute procedural success compared to the DMR patient group (91.2% vs. 95.2%; P=0.016). A greater portion of DMR patients implanted two or more MCs than the FMR patients (41.4% vs. 35.7%; P=0.043). For the 1-year outcomes, no difference was found in the mortality rate (13.0% vs. 15.2%; P=0.268) and proportion of patients with post-procedural MR grades 0-2 (75.0% vs. 80.7%; P=0.106). Conclusions: Despite a higher risk profile in FMR patients, the short-term and 1-year outcomes were not significantly different. We conclude that MC therapy is similar between FMR and DMR patients until 1-year follow-up. Large randomized trials are warranted to fully and further assess the clinical impact of the procedure in these two MR etiologies over a longer period of time.

8.
Ying Yong Sheng Tai Xue Bao ; 29(1): 125-132, 2018 Jan.
Artigo em Chinês | MEDLINE | ID: mdl-29692020

RESUMO

A low temperature treatment in rice booting key period was executed on the north slope of Changbai Mountains to construct the impact model of low temperature on rice shell rate, and to reveal the effects of low temperature at different stages of rice young panicle on seed setting. The results showed that effects of low temperature in the young ear formation stage on rice shell rate generally followed the logarithmic function, the lower the temperature was, the greater the temperature influence coefficient was, and the longer the low temperature duration was, the higher rice shell rate was. The seed setting rate was most sensitive to low temperature in the middle time of booting stage (the period from formation to meiosis of the pollen mother cell), followed by the early and later stages. During the booting stage, with 1 ℃ decrease of daily temperature under 2-, 3- and 5-day low temperature treatments, the shell rate increased by 0.5, 1.7 and 4.3 percentage, respectively, and with 1 ℃ decrease of daily minimum temperature, the shell rate increased by 0.4,1.8 and 4.5 percentage, respectively. The impact of 2-day low temperature was smaller than that of 3 days or more. The impact of accumulative cold-temperature on the shell rate followed exponential function. In the range of harmful low temperature, rice shell rate increased about 8.5 percentage with the accumulative cold-temperature increasing 10 ℃·d. When the 3 days average temperature dropped to 21.6, 18.0 and 15.0 ℃, or the 5 days average temperature dropped to 22.0, 20.4 and 18.5 ℃, or the accumulative cold-temperature was more than 8, 19, 26 ℃·d, the light, moderate and severe booting stage chilling injury would occur, respectively. In Northeast China, low temperature within 2 d in rice booting stage might not cause moderate and severe chilling injury.


Assuntos
Temperatura Baixa , Oryza/crescimento & desenvolvimento , China , Sementes , Temperatura Ambiente
9.
Nanoscale ; 5(17): 8146-55, 2013 Sep 07.
Artigo em Inglês | MEDLINE | ID: mdl-23884249

RESUMO

Mesoporous silica (m-SiO2) coated gadolinium (Gd) ions-doped upconversion nanoparticles (UCNPs) are regarded as one of most attractive nano-platforms which hold great potential in future cancer theranostics. The current general synthetic strategy for such promising structures includes the extraction of surfactant molecules in the final step. Here, in this article, we focus our interest on probing the potential influence of hydrochloric acid extraction on lanthanide ions leakage, MR sensitivity over-estimation and the optical intensity weakening of m-SiO2 coated Gd-doped UCNPs. Control experiments provide evidence of inner core damage, Gd(3+) ion release and residual Gd(3+) ions "trapped" within the core@shell structures. Our investigation shows that: (1) the small Gd-doped UCNPs could be fragile and sensitive to the hydrochloric acid-extraction and thermal treatment processes; and (2) the presence of "trapped" Gd(3+) ions not only provokes the concerns of potential cytotoxicity but also interfere with the contrast imaging tests of Gd-doped UCNPs, providing possible erroneous information on the determination of the longitudinal relaxivities of given probes.


Assuntos
Gadolínio/química , Nanopartículas/química , Dióxido de Silício/química , Sobrevivência Celular/efeitos dos fármacos , Meios de Contraste/química , Meios de Contraste/toxicidade , Células HeLa , Humanos , Íons/química , Imagem por Ressonância Magnética , Microscopia Eletrônica de Transmissão , Nanopartículas/toxicidade , Porosidade
10.
J Urol ; 189(2): 447-53, 2013 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-23253956

RESUMO

PURPOSE: Accurate assessment of disease characteristics is a prerequisite for treatment decision making regarding small renal masses. In this study we evaluate the association between visceral obesity and Fuhrman grade in patients with cT1a renal cell carcinoma. MATERIALS AND METHODS: We retrospectively collected data on 186 patients with surgically treated cT1a renal cell carcinoma. Single slice computerized tomography was used to measure the area of visceral and subcutaneous adipose tissue. Visceral obesity was calculated as the proportion of visceral adipose tissue to overall adipose tissue. Other analyzed factors included clinical characteristics (age, gender, body mass index and tumor size) and anatomical features of the tumor defined by the R.E.N.A.L. nephrometry score. The association between predictors and high grade disease (Fuhrman grade III or IV) were assessed using logistic regression analyses. RESULTS: A total of 47 (25.3%) tumors were classified as high grade. The percentage of visceral adipose tissue was higher in male participants but did not correlate with body mass index, age or tumor size. In univariate analyses the percentage of visceral adipose tissue and tumor size were significantly associated with higher Fuhrman grade. Multivariate analysis showed that the percentage of visceral adipose tissue (OR 1.06, p = 0.0018) and tumor size (OR 1.91, p = 0.047) were independent predictors of high grade cancer. Addition of the percentage of visceral adipose tissue to a model including clinical characteristics and anatomical features of the tumor remarkably improved its discriminatory ability (p = 0.0010). CONCLUSIONS: Increased visceral obesity was found to be strongly associated with higher Fuhrman grade in patients with cT1a renal cell carcinoma. Further studies are needed to confirm these findings and discover the underlying biological mechanism.


Assuntos
Carcinoma de Células Renais/complicações , Carcinoma de Células Renais/patologia , Neoplasias Renais/complicações , Neoplasias Renais/patologia , Obesidade Abdominal/complicações , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Gradação de Tumores , Estadiamento de Neoplasias , Estudos Retrospectivos , Fatores de Risco , Adulto Jovem
11.
Zhonghua Yan Ke Za Zhi ; 49(11): 993-6, 2013 Nov.
Artigo em Chinês | MEDLINE | ID: mdl-24513000

RESUMO

OBJECTIVE: To measure and accumulate imaging anatomical data of lacrimal sac and medial canthal artery, and provide the knowledge for clinical diagnosis and therapy of lacrimal diseases. METHODS: 80 volunteers(80 eyes) who were eliminated the tearing related diseases by ophthalmologist were included. GE Voluson E8 ultrasound diagnostic apparatus with probe of high frequency 5-12 MHz was used, the probe of the three-dimensional ultrasound contacted eyes indirectly. The vertical diameter, anteroposterior diameter, width of lacrimal sac were measured, and vertical distance between top to bottom of lacrimal sac and medial canthus to skin, vertical distance between medial canthal artery and medial canthus to skin were also measured. RESULTS: The measurement results of adult male subjects of lacrimal sac cavity vertical diameter and anteroposterior diameter and diameter were (13.3 ± 2.0) mm, (6.2 ± 1.1) mm, (5.0 ± 0.9) mm; the measurement results of adult female subjects of lacrimal sac cavity vertical diameter and anteroposterior diameter and diameter were (13.1 ± 2.2) mm, (5.8 ± 1.0) mm, (4.8 ± 0.8) mm, the difference was not statistically significant(t = 1.63, 1.45, 1.41, P > 0.05). The measurement results of adult male subjects of lacrimal sac cavity (top, bottom) to the top of the skin surface and medial canthal were (6.5 ± 0.1) mm, (5.9 ± 0.1) mm, (6.8 ± 0.1) mm, (8.8 ± 0.1) mm; the adult female group measurements were (6.1 ± 0.1) mm, (5.7 ± 0.1) mm, (6.2 ± 0.1) mm, (8.6 ± 0.1) mm, the difference was not statistically significant(t = 1.30, 1.56, 1.45, 1.63, P > 0.05). The measurement results of adult male subjects vertex are angular artery to the skin surface and medial canthal were (7.7 ± 0.1) mm, (8.0 ± 0.0) mm; the adult female group measurements respectively (7.6 ± 0.1) mm, (7.9 ± 0.1) mm, the difference was not statistically significant(t = 1.38, 1.34, P > 0.05). CONCLUSIONS: Lacrimal sac and medial canthal artery can be showed clearly in three-dimensional ultrasound reconstruction, this can provide the guidance for clinical diagnosis and therapy of lacrimal diseases.


Assuntos
Imagem Tridimensional , Aparelho Lacrimal/diagnóstico por imagem , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Aparelho Lacrimal/anatomia & histologia , Masculino , Pessoa de Meia-Idade , Ducto Nasolacrimal/anatomia & histologia , Ducto Nasolacrimal/diagnóstico por imagem , Ultrassonografia , Adulto Jovem
12.
Zhonghua Yi Xue Za Zhi ; 92(8): 512-5, 2012 Feb 28.
Artigo em Chinês | MEDLINE | ID: mdl-22490151

RESUMO

OBJECTIVE: To retrospectively analyze the clinical value of diffusion-weighted magnetic resonance imaging (MRDWI) in the detection of prostate cancer in suspected patients. METHODS: Between January 2009 and December 2010, 141 patients with suspected prostate cancer underwent MRDWI and transrectal ultrasound (TRUS) guided prostate biopsy. They were divided into 4 groups by prostate surface antigen (PSA) < 10 µg/L, 10 µg/L ≤ PSA < 20 µg/L, 20 µg/L ≤ PSA < 50 µg/L and PSA ≥ 50 µg/L. Then the diagnostic accuracy of MRDWI was tested. RESULTS: The diagnostic rate of patients with PSA < 10 µg/L, 10 µg/L ≤ PSA < 20 µg/L, 20 µg/L ≤ PSA < 50 µg/L and PSA ≥ 50 µg/L were 23.7%, 35.5%, 66.7% and 96.3% respectively. The sensitivity of MRDWI was significantly better than TRUS. In patients with PSA < 10 µg/L, 10 µg/L ≤ PSA < 20 µg/L, 20 µg/L ≤ PSA < 50 µg/L and PSA ≥ 50 µg/L, the patient-based sensitivities were 85.7%, 72.7%, 97.8%, 100.0% respectively; when based by segment of specimen, the sensitivities were 85.5%, 71.9%, 91.5% and 94.4% respectively. CONCLUSION: The sensitivity of MDWI is significantly better than TRUS in the diagnosis of prostate cancer. The combined use of MDWI and TRUS has the benefit of guiding the biopsy of cancer foci in patients with suspected prostate cancer.


Assuntos
Biópsia/métodos , Imagem de Difusão por Ressonância Magnética , Neoplasias da Próstata/diagnóstico , Humanos , Masculino , Próstata/diagnóstico por imagem , Próstata/patologia , Neoplasias da Próstata/diagnóstico por imagem , Neoplasias da Próstata/patologia , Reto/diagnóstico por imagem , Estudos Retrospectivos , Sensibilidade e Especificidade , Ultrassonografia
13.
Zhonghua Wai Ke Za Zhi ; 50(1): 35-8, 2012 Jan 01.
Artigo em Chinês | MEDLINE | ID: mdl-22490288

RESUMO

OBJECTIVE: To retrospectively analyze the clinical value of diffusion-weighted MR imaging in the detection of prostate cancer in suspected patients. METHODS: Between January 2009 and December 2010, the 551 patients suspected as prostate cancer underwent prostate biopsy. Patients in group A were accepted to a transrectal ultrasound (TRUS) guided transrectal prostate biopsy (n = 410), while patients in group B were accepted to a diffusion weighted imaging (DWI) and TRUS jointly guided transrectal prostate biopsy (n = 141). The two groups were divided into 4 subgroups by prostate specific antigen (PSA) < 10 µg/L, 10 µg/L ≤ PSA < 20 µg/L, 20 µg/L ≤ PSA < 50 µg/L and PSA ≥ 50 µg/L. Then, the diagnostic rates of prostate biopsy guided by combination of DWI and TRUS with only TRUS were compared. RESULTS: The diagnostic rate of patients with PSA < 10 µg/L, 10 µg/L ≤ PSA < 20 µg/L, 20 µg/L ≤ PSA < 50 µg/L and PSA ≥ 50 µg/L were 12.1%, 31.1%, 48.0%, 91.2% in group A, and 23.7%, 35.5%, 66.7%, 96.3% in group B, respectively. In the patients with PSA less than 10 µg/L, there were significant differences in diagnostic rate between the two biopsy techniques (χ(2) = 4.405, P < 0.05). CONCLUSION: The combination of DWI and TRUS showed the potential to guide biopsy to cancer foci in patients suspected as prostate cancer. For patients with PSA < 10 µg/L, a DWI and TRUS jointly guided transrectal prostate biopsy was recommended.


Assuntos
Biópsia por Agulha/métodos , Imagem por Ressonância Magnética , Próstata/patologia , Neoplasias da Próstata/diagnóstico , Endossonografia , Humanos , Masculino , Próstata/diagnóstico por imagem , Neoplasias da Próstata/patologia , Estudos Retrospectivos
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