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1.
Curr Oncol ; 29(9): 6035-6052, 2022 Aug 23.
Artigo em Inglês | MEDLINE | ID: mdl-36135044

RESUMO

Genomic instability facilitates the evolution of cells, tissues, organs, and species. The progression of human malignancies can be regarded as the accumulation of genomic instability, which confers a high evolutionary potential for tumor cells to adapt to continuous changes in the tumor microenvironment. Nasopharyngeal carcinoma (NPC) is a head-and-neck squamous-cell carcinoma closely associated with Epstein-Barr virus (EBV) infection. NPC progression is driven by a combination of accumulated genomic instability and persistent EBV infection. Here, we present a review of the key characteristics of genomic instability in NPC and the profound implications of EBV infection. We further discuss the significance of profiling genomic instability for the assessment of disease progression and treatment efficacy, as well as the opportunities and challenges of targeted therapies for NPC based on its unique genomic instability.


Assuntos
Carcinoma , Infecções por Vírus Epstein-Barr , Neoplasias Nasofaríngeas , Carcinoma/genética , Carcinoma/patologia , Infecções por Vírus Epstein-Barr/complicações , Infecções por Vírus Epstein-Barr/genética , Infecções por Vírus Epstein-Barr/patologia , Instabilidade Genômica , Herpesvirus Humano 4/genética , Humanos , Carcinoma Nasofaríngeo/genética , Neoplasias Nasofaríngeas/genética , Neoplasias Nasofaríngeas/patologia , Microambiente Tumoral
2.
Front Pharmacol ; 13: 949869, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36147339

RESUMO

The emergence of polymyxin B (PB) resistant Gram-negative bacteria poses an important clinical and public health threat. Antibiotic adjuvants development is a complementary strategy that fills the gap in new antibiotics. Here, we described the discovery of the enhancement capacity of compound 666-15, previously identified as an inhibitor of cyclic adenosine monophosphate response element-binding protein (CREB), on the activity of PB against Klebsiella pneumoniae in vitro and in vivo. Mechanistic studies showed that this compound reduced the transcription and translation levels of genes related to lipid A modification in the presence of PB. We also identified that 666-15 reduces the ATP hydrolyzation activity of CrrB, and P151L mutation mediates the resistance of bacteria to the enhancement of 666-15. Our results demonstrated the potential of 666-15 in clinical application and support the further development of a PB synergist based on this compound.

3.
Front Pharmacol ; 13: 966645, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36147345

RESUMO

Necroptosis was elevated in both tubulointerstitial and glomerular renal tissue in patients with diabetic kidney disease (DKD), and was most pronounced on glomerulus in the stage with macroalbuminuria. This study further explored whether paeoniflorin (PF) could affect podocyte necroptosis to protect kidney injure in vivo and in vitro. Our study firstly verified that there are obvious necroptosis-related changes in the glomeruli of DKD through bioinformatics analysis combined with clinicopathological data. STZ-induced mouse diabetes model and high-glucose induced podocyte injury model were used to evaluate the renoprotection, podocyte injury protection and necroptosis regulation of PF in DKD. Subsequently, the target protein-TNFR1 that PF acted on podocytes was found by computer target prediction, and then molecular docking and Surface plasmon resonance (SPR) experiments were performed to verify that PF had the ability to directly bind to TNFR1 protein. Finally, knockdown of TNFR1 on podocytes in vitro verified that PF mainly regulated the programmed necrosis of podocytes induced by high glucose through TNFR1. In conclusion, PF can directly bind and promote the degradation of TNFR1 in podocytes and then regulate the RIPK1/RIPK3 signaling pathway to affect necroptosis, thus preventing podocyte injury in DKD. Thus, TNFR1 may be used as a new potential target to treat DKD.

4.
Front Cardiovasc Med ; 9: 943377, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36148074

RESUMO

Background: Sacubitril/valsartan therapy reduced the risks of death and of hospitalization for heart failure (HF). HF and cardiac arrhythmias have shared physiological mechanisems. Therefore, sacubitril/valsartan may exhibit anti-arrhythmic properties in HF. The purpose of this study was to evaluate the effect of sacubitril/valsartan on the occurrence of cardiac arrhythmias and the risk of sudden cardiac death (SCD) in HF. Methods: This meta-analysis was performed according to PRISMA guidelines. We searched PubMed and Embase (from inception up to 6 February 2022) to identify randomized control trials (RCTs) on the effect of sacubitril/valsartan on the occurrence of cardiac arrhythmias and the risk of SCD in HF. Primary outcomes were the occurrence of atrial arrhythmias, ventricular arrhythmias, and SCD. Risk ratios (RRs) with 95% confidence intervals (CIs) were pooled using a random-effects model for meta-analysis. Results: We included 9 RCTs (published between 2012 and 2021) with 18,500 patients (9,244 sacubitril/valsartan vs. 9,256 active control). Enalapril and valsartan were used as active control in six and two studies, respectively. Follow-up ranged from 2 to 35 months. The cumulative occurrence of events was 76, 13, and 48 per 1,000 patient-years for atrial arrhythmias, ventricular arrhythmias and SCD, respectively. There was no significant association between sacubitril/valsartan therapy and the occurrence of atrial arrhythmias (RR 1.06; 95% CI: 0.97-1.17; P = 0.19) and ventricular arrhythmias (RR 0.86; 95% CI 0.68-1.10; P = 0.24). However, sacubitril/valsartan therapy significantly reduced the risk of SCD (RR 0.79; 95% CI 0.70-0.90; P = 0.03) compared with control. Conclusion: No association between sacubitril/valsartan therapy and the occurrence of atrial and ventricular arrhythmias was found, but sacubitril/valsartan therapy significantly reduced the risk of SCD.

5.
Stem Cells ; 2022 Sep 25.
Artigo em Inglês | MEDLINE | ID: mdl-36153788

RESUMO

The inner ear is derived from the otic placode, one of numerous cranial sensory placodes that emerges from the pre-placodal ectoderm (PPE) along its anterior-posterior axis. However, the molecular dynamics underlying how the PPE is regionalized are poorly resolved. We used stem cell-derived organoids to investigate the effects of Wnt signaling on early PPE differentiation and found that modulating Wnt signaling significantly increased inner ear organoid induction efficiency and reproducibility. Alongside single-cell RNA sequencing, our data reveal that the canonical Wnt signaling pathway leads to PPE regionalization and, more specifically, medium Wnt levels during the early stage induce 1) expansion of the caudal neural plate border (NPB), which serves as a precursor for the posterior PPE, and 2) a caudal microenvironment that is required for otic specification. Our data further demonstrate Wnt-mediated induction of rostral and caudal cells in organoids and more broadly suggest that Wnt signaling is critical for anterior-posterior patterning in the PPE.

6.
Biomed Mater ; 2022 Sep 28.
Artigo em Inglês | MEDLINE | ID: mdl-36170861

RESUMO

Native bone tissue can be formed by developing collagen fibrils coated with hydroxyapatite (HA) and whitlockite (WH) nanoparticles after mineralization. WH has attracted much attention as the second most abundant bone mineral in human bones. It has a negatively charged surface, which can adsorb osteogenesis-related proteins such as bone sialoprotein(BSP) in vivo, thus having a stronger possibility to induce osteogenesis. However, due to its poor thermodynamic stability and intermediate phases, the preparation of WH is relatively tricky, so WH inorganic scaffolds are still rarely studied. Therefore, this study explored the preparation of WH inorganic scaffolds using the hydrothermal method and prepared pure inorganic WH scaffolds. The prepared scaffolds exhibited apparent WH crystal phases in the XRD characterization. In the SEM images, the WH scaffolds had an apparent hexagonal crystal form, which had a pronounced effect on promoting cell proliferation and differentiation in vitro experiments compared to the HA and HA/WH scaffolds. Furthermore, the scaffolds were used to verify the osteogenic properties of subcutaneous ectopic osteogenesis or repair of the calvarial defect in vivo and proved that the WH inorganic scaffolds have an excellent synergistic osteogenic ability.

7.
Org Lett ; 24(38): 6897-6902, 2022 Sep 30.
Artigo em Inglês | MEDLINE | ID: mdl-36112971

RESUMO

In this paper, in the presence of trimethylsilyl iodide, the direct ortho-C-H hydroxyalkylation/methylation of aryl iodines was effectively realized via palladium/norbornene cooperative catalysis when low-cost tetrahydrofuran and 1,2-dimethoxyethane were used as alkyl sources. Heck, Suzuki, and Sonogashira coupling and hydrogenation were all compatible with the reaction as termination steps. In addition, neuromuscular agents and cardiovascular agents were synthesized in one step by this method, showing their potential application value.

8.
Front Psychol ; 13: 982012, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36072035

RESUMO

Children's lying is a major concern for parents and teachers alike, not only because lying is an antisocial behavior but also because children's lying correlates with other behavior problems, such as aggression and delinquency. Despite considerable correlational evidence demonstrating the relation between children's lying and behavior problems, experimental evidence is scarce. This study uses a novel task to experimentally examine the relation between lying for personal reward and behavior problem symptoms among 9- to 11-year-old typically developed children (N = 275, 139 boys). Results revealed a positive correlation between children's lying for personal reward and their behavior problem symptoms, and this correlation increases with age. Overall, this study provides experimental evidence suggesting children's lying for personal reward is associated with behavior problems.

9.
Front Chem ; 10: 984652, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36072706

RESUMO

High strength polyvinyl alcohol (PVA)/soy protein isolate (SPI) composite hydrogels (EPSG) were constructed by the introduction of PVA into SPI through the crosslinking with epichlorohydrin (ECH) and a freezing-thawing process. The EPSG hydrogels were characterized by scanning electron microscopy, FTIR, X-ray diffraction and compressive test. The results revealed that chemical crosslinking interactions occurred for SPI and PVA during the fabrication process. The composite hydrogels exhibited a homogenous porous structure, indicating certain miscibility between PVA and SPI. The introduction of PVA increased the compressive strength of SPI hydrogels greatly, which could reach as high as 5.38 MPa with the water content ratio of 89.5%. Moreover, the water uptake ratio of completely dried SPI hydrogel (namely xerogel) decreased gradually from 327.4% to 148.1% with the incorporation of PVA, showing a better potential as implants. The cytocompatibility and hemocompatibility of the EPSG hydrogels were evaluated by a series of in vitro experiments. The results showed that the EPSG hydrogels had no cytotoxicity (cell viability values were above 86.7%), good biocompatibility and hemocompatibility, showing potential applications as a direct blood contact material in the field of tissue engineering.

10.
Front Pharmacol ; 13: 981766, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36081937

RESUMO

Background and Purpose: We have previously reported a cardioprotective effect with Xin-Ji-Er-Kang (XJEK) treatment in mice with myocardial infarction (MI)-induced heart failure, but no report about its potential functions in myocardial ischemia-reperfusion (MIR) injury. Here we studied the therapeutic effects of XJEK on MIR injury and investigated the mechanisms involved. Experimental Approach: MIR model of Balb/c mice induced by left anterior descending coronary artery ligation for half an hour, followed by reperfusion, was utilized to study the potential therapeutic effects of XJEK on MIR-induced cardiac injury. Ultra-performance liquid chromatography tandem Orbitrap mass spectrometry platform was used for studying serum lipid metabolic signatures. Key Results: MIR caused cardiac dysfunctions, cardiac injury, myocardial fibrosis, and increased inflammation, and all the observed abnormalities caused by MIR were largely corrected by XJEK treatment. Mechanistically, XJEK exerts its cardioprotective effect in the context of MIR injury by suppressing MIR-induced inflammation and dysregulation of serum lipid metabolism. Conclusion and Implications: We have demonstrated for the first time that XJEK protects heart from MIR injury by restoring dysregulated lipidomics. Our data provide new evidence to support a therapeutic effect for XIEK on MIR-induced cardiac injury, and pave the way for exploring the therapeutic potential of XJEK in large animal study and early clinical trial.

11.
Sci Total Environ ; : 158736, 2022 Sep 16.
Artigo em Inglês | MEDLINE | ID: mdl-36122720

RESUMO

Atmospheric nitrate (NO3-) produced by photochemical oxidation in the atmosphere has high oxygen isotope ratios (δ18O values). Recently, the primary NO3- emitted from combustion sources was found to have much lower δ18O values. However, it is unclear how and to what extents the low δ18O signatures were controlled by major O sources during the primary NO3- formation of combustion processes. Here, we first measured concentrations and δ18O values of NO3- from burning five biomass materials (bb-NO3- and δ18Obb-NO3-, respectively) in China. Distinctly higher concentration levels of the bb-NO3- emissions (42.1 ±â€¯8.1 µmol m-3) than ambient NO3- suggest it is a potential source of atmospheric NO3- pollution. Much lower δ18Obb-NO3- signatures (27.6 ±â€¯2.7 ‰) than ambient NO3- support it as a primary emission source with different O sources and formation mechanism from secondary NO3-. Isotope mass-balance modeling revealed that atmospheric O2 and the biomass O dominated the O of bb-NO3- (53 ±â€¯7 % and 40 ±â€¯4 %, respectively) over the aqueous vapor (7 ±â€¯3 %). Besides, we found increasing δ18Obb-NO3- values with the biomass N contents and relatively lower δ18Obb-NO3- values for biomasses with higher carbon (C) and lower O contents, indicating that biomass C, N, and O contents may influence the source O contributions of the bb-NO3-. This work provides a novel isotope analysis on the O source contribution of the bb-NO3-, which is useful for understanding the formation mechanism of combustion-related NO3- sources and evaluating the primary NO3- emissions.

12.
Ann Transl Med ; 10(16): 896, 2022 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-36111015

RESUMO

Background: Idiopathic pulmonary fibrosis (IPF) is a disease with a very poor prognosis. The search for new IPF biomarkers is particularly urgent due to the uncertainty of the mechanisms and treatment. Studies have shown that chromatin regulators (CRs) are involved in the development of IPF and are associated with tumor immunity. However, there are no studies on immune-related CRs in IPF. Therefore, we conducted a systematic study to analyze the expression levels and immune correlation of CRs in IPF tissues and normal tissues and to explore their potential as diagnostic biomarkers. Methods: GSE53845, GSE179781 and GSE24206 datasets from Gene Expression Omnibus (GEO) database were merged into an integrated dataset as the training set; GSE70866 was used as the validation dataset. The cr-related differentially expressed genes (DEGs) between normal and IPF tissues were identified using the "Limma" software package. Weighted gene co-expression network analysis (WGCNA) was performed using the "WGCNA" package to screen eigengenes, which were intersected with DEGs to identify hub genes. The "ggcorrplot" package was used to analyze the correlation between hub genes and immunity, and immune-related hub genes were defined as immHub. A logistic regression model was constructed using immHub as the independent variable and whether the diagnosis was IPF as the dependent variable. Results: One hundred and sixty-nine DEGs were identified between IPF and normal tissues. wGCNA identified 3 key modules in brown, green and yellow genes that were present in all 3 modules and met module membership (MM) >0.8 and gene significance (GS) >0.5 were called signature genes (n=390). Four intersecting genes were obtained by intersecting DEGs with signature genes (PADI4, IGFBP7, GADD45A, and SETBP1) all associated with immunity were defined as immHub genes Logistic regression models were constructed based on immHub genes. The area under the curve (AUC) of the ROC curve is used to evaluate the diagnostic accuracy of the logistic regression model for IPF. The AUC in the ROC analysis was 0.771 for the training dataset, and 0.759 for the validation dataset. Conclusions: PADI4, IGFBP7 and GADD45A may be biomarkers for IPF, which will provide assistance in the diagnosis, treatment and prognostic assessment of IPF patients, and provide an important basis for future studies on the relationship between CRs genes and IPF.

13.
Natl Sci Rev ; 9(9): nwac106, 2022 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-36128454

RESUMO

Nitrogen oxides (NOx, the sum of nitric oxide (NO) and N dioxide (NO2)) emissions and deposition have increased markedly over the past several decades, resulting in many adverse outcomes in both terrestrial and oceanic environments. However, because the microbial NOx emissions have been substantially underestimated on the land and unconstrained in the ocean, the global microbial NOx emissions and their importance relative to the known fossil-fuel NOx emissions remain unclear. Here we complied data on stable N isotopes of nitrate in atmospheric particulates over the land and ocean to ground-truth estimates of NOx emissions worldwide. By considering the N isotope effect of NOx transformations to particulate nitrate combined with dominant NOx emissions in the land (coal combustion, oil combustion, biomass burning and microbial N cycle) and ocean (oil combustion, microbial N cycle), we demonstrated that microbial NOx emissions account for 24 ± 4%, 58 ± 3% and 31 ± 12% in the land, ocean and global environment, respectively. Corresponding amounts of microbial NOx emissions in the land (13.6 ± 4.7 Tg N yr-1), ocean (8.8 ± 1.5 Tg N yr-1) and globe (22.5 ± 4.7 Tg N yr-1) are about 0.5, 1.4 and 0.6 times on average those of fossil-fuel NOx emissions in these sectors. Our findings provide empirical constraints on model predictions, revealing significant contributions of the microbial N cycle to regional NOx emissions into the atmospheric system, which is critical information for mitigating strategies, budgeting N deposition and evaluating the effects of atmospheric NOx loading on the world.

14.
Chem Asian J ; 2022 Sep 22.
Artigo em Inglês | MEDLINE | ID: mdl-36136743

RESUMO

Herein, we disclose the first versatile and expeditious modular approach for the rapid diversity-oriented synthesis (DOS) of the difunctionalized ß-fluoroalkylated arenes via Pd/norbornene cooperative catalysis. This protocol features an excellent functional group tolerance, as well as a broad ipso termination scope. Moreover, this methodology can be expanded to the late-stage modification of biorelevant molecules. Of particular note, this protocol could also streamline the rapid modular assembly of the 13 and 14-membered fluorinated macrolactones, which was extremely challenging otherwise and the resulted ß-fluoroalkylated phenylacetylenes could undergo diverse transformations to provide interesting scaffolds.

15.
16.
Foods ; 11(17)2022 Aug 24.
Artigo em Inglês | MEDLINE | ID: mdl-36076742

RESUMO

Most polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) and dioxin-like polychlorinated biphenyls (DL-PCBs) in the human body are acquired from dietary intake. The chronic exposure of humans to PCDD/Fs and DL-PCBs is a major health concern, and these compounds are strictly controlled in many areas. This study measured the levels of PCDD/Fs and DL-PCBs in Chinese mitten crab (Eriocheir sinensis) farms in Shanghai and determined potential sources. The mean concentrations of PCDD/Fs and DL-PCBs in the studied crab samples were 264.20 ± 260.14 and 506.25 ± 226.80 pg/g ww (wet weight), respectively. The range of the toxic equivalent (TEQ) for the total PCDD/Fs and DL-PCBs in the crab samples was 1.20-29.04 pg TEQ/g ww. Further analysis revealed that the TEQ input to crabs in aquacultural water was 1.6 times higher than the TEQ in edible crab parts. Aquatic plants, shore plants, and feed contributed about 0.05% of the total TEQ input to crabs. The TEQ contribution from sediment was 317 times that found in edible crab parts, and sediment may be the most prevalent source of PCDD/Fs and DL-PCBs in farm crabs. The evaluation of the Shanghai market crab revealed different levels of PCDD/Fs and DL-PCBs. The TEQs for the mean PCDD/F and DL-PCB levels were 1.55 ± 1.96 and 1.05 ± 0.55 pg TEQ/g ww, respectively. The tolerable daily intake (TDI) levels of adults and children were lower than the prescribed range (1-4 pg TEQ/kg (weight)·d), indicating no significant chronic or acute ingestion risk for adults and children.

17.
Foods ; 11(17)2022 Aug 25.
Artigo em Inglês | MEDLINE | ID: mdl-36076751

RESUMO

Shigella flexneri (Sh. flexneri), which can be found in food and the environment, is a widespread food-borne pathogen that causes human diarrhea termed "shigellosis". In this study, eugenol, a natural active substance, was investigated for its antibacterial activity against Sh. flexneri. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of eugenol against Sh. flexneri ATCC 12022 was 0.5 and 0.8 mg/mL. The growth curves and inhibitory effect in LB broth, PBS, vegetable juice, and minced pork showed that eugenol had a good activity against Sh. flexneri. Research findings indicated the superoxide dismutase activity of Sh. flexneri was inhibited after eugenol treatment, resulting in concentrations of intracellular reactive oxygen species and an increase in malondialdehyde. The flow cytometry analysis and field emission scanning electron microscopy results revealed obvious damage to cell membrane integrity and changes in the morphology of Sh. flexneri. In addition, the intracellular ATP concentration leaked from 0.5 µM to below 0.05 µM and the membrane potential showed a concentration-dependent depolarization after eugenol treatment. In summary, eugenol exerted strong antibacterial activity and has the potential to control Sh. flexneri in the food industry.

18.
Cancers (Basel) ; 14(17)2022 Aug 30.
Artigo em Inglês | MEDLINE | ID: mdl-36077763

RESUMO

Lymph nodes metastases are common in patients with lung cancer. Additionally, those patients are often at a higher risk for death from lung tumor than those with tumor-free lymph nodes. Somatic DNA alterations are key drivers of cancer, and copy number alterations (CNAs) are major types of DNA alteration that promote lung cancer progression. Here, we performed genome-wide DNA copy number analysis, and identified a novel lung-cancer-metastasis-related gene, EFNA4. The EFNA4 genome locus was significantly amplified, and EFNA4 mRNA expression was significantly up-regulated in lung cancer compared with normal lung tissue, and also in lung cancer with lymph node metastases compared with lung cancer without metastasis. EFNA4 encodes Ephrin A4, which is the ligand for Eph receptors. The function of EFNA4 in human lung cancer remains largely unknown. Through cell line experiments we showed that EFNA4 overexpression contributes to lung tumor cells growth, migration and adhesion. Conversely, EFNA4 knockdown or knockout led to the growth suppression of cells and tumor xenografts in mice. Lung cancer patients with EFNA4 overexpression have poor prognosis. Together, by elucidating a new layer of the role of EFNA4 in tumor proliferation and migration, our study demonstrates a better understanding of the function of the significantly amplified and overexpressed gene EFNA4 in lung tumor metastasis, and suggests EFNA4 as a potential target in metastatic lung cancer therapy.

19.
Org Lett ; 24(36): 6566-6570, 2022 Sep 16.
Artigo em Inglês | MEDLINE | ID: mdl-36053062

RESUMO

Herein, we describe a novel and efficient photoredox catalytic radical addition/defluoroalkylation coupling reaction between primary amines and trifluoromethyl-substituted alkenes. A series of gem-difluoroalkenes were synthesized via C-N bond cleavage of α-3°, α-2°, and α-1° amines under visible light irradiation. This reaction is characterized by a broad substrate scope and good functional group tolerance.

20.
Front Oncol ; 12: 966529, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36059674

RESUMO

Background: The presence of lymphovascular space invasion (LVSI) has been demonstrated to be significantly associated with poor outcome in endometrial cancer (EC). No effective clinical tools could be used for the prediction of LVSI preoperatively in early-stage EC. A radiomics nomogram based on MRI was established to predict LVSI in patients with early-stage EC. Methods: This retrospective study included 339 consecutive patients with early-stage EC with or without LVSI from five centers. According to the ratio of 2:1, 226 and 113 patients were randomly assigned to a training group and a test group, respectively. Radiomics features were extracted from T1-weighted imaging (T1WI), T2-weighted imaging (T2WI), contrast-enhanced (CE), diffusion-weighted imaging (DWI), and apparent diffusion coefficient (ADC) maps. The radiomics signatures were constructed by using the Least Absolute Shrinkage and Selection Operator (LASSO) algorithm in the training group. The radiomics nomogram was developed using multivariable logistic regression analysis by incorporating radiomics signatures and clinical risk factors. The sensitivity, specificity, and AUC of the radiomics signatures, clinical risk factors, and radiomics nomogram were also calculated. Results: The individualized prediction nomogram was constructed by incorporating the radiomics signatures with the clinical risk factors (age and cancer antigen 125). The radiomics nomogram exhibited a good performance in discriminating between negative and positive LVSI patients with AUC of 0.89 (95% CI: 0.83-0.95) in the training group and of 0.85 (95% CI: 0.75-0.94) in the test group. The decision curve analysis indicated that clinicians could be benefit from the using of radiomics nomogram to predict the presence of LVSI preoperatively. Conclusion: The radiomics nomogram could individually predict LVSI in early-stage EC patients. The nomogram could be conveniently used to facilitate the treatment decision for clinicians.

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