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1.
Sichuan Da Xue Xue Bao Yi Xue Ban ; 53(1): 49-53, 2022 Jan.
Artigo em Chinês | MEDLINE | ID: mdl-35048599

RESUMO

Among patients undergoing elective non-cardiac surgery (NCS), those with coronary stent implants are gradually becoming a patient group that cannot be easily overlooked. Previous history of heart disease, coronary stents and antiplatelet agents expose these patients to dual perioperative risks of thrombosis and bleeding. Formulating appropriate plans for perioperative antiplatelet therapy will help reduce the risks and ensure the safety of patients. We herein reviewed and analyzed various aspects of perioperative antiplatelet therapy for patients with coronary stent implants undergoing elective NCS, and discussed prospective research directions in the field.


Assuntos
Inibidores da Agregação Plaquetária , Stents , Procedimentos Cirúrgicos Eletivos , Hemorragia , Humanos , Inibidores da Agregação Plaquetária/uso terapêutico , Estudos Prospectivos
2.
Chem Commun (Camb) ; 58(5): 697-700, 2022 Jan 13.
Artigo em Inglês | MEDLINE | ID: mdl-34920448

RESUMO

We choose copper(II) ions to salinize maleic acid, then form a layered copper maleate hydrate and apply this as an anode material for LIBs for the first time. The as-prepared material exhibits admirable electrochemical performance (404.6 mA h g-1 at 0.2 A g-1). A new hypothesis is developed for a better understanding of the unusual in situ XRD results and reaction mechanism.

3.
J Orthop Traumatol ; 22(1): 52, 2021 Dec 10.
Artigo em Inglês | MEDLINE | ID: mdl-34890022

RESUMO

BACKGROUND: Intraarticular impacted fragment (IAIF) of posterior malleolar fractures has been reported by a few studies. However its location, morphology, and the correlation of posterior malleolar fractures have not been described in detail. The aim of this study was to describe the morphology of IAIF in posterior malleolar fractures, to analyze the related factors between IAIF and posterior malleolar fragments, and explore the treatment of IAIF. MATERIALS AND METHODS: Between January 2013 and December 2018, 108 consecutive patients with unilateral posterior malleolar fractures were managed in our hospital. Basic demographic and computed tomography (CT) data were collected and classified by Lauge-Hansen, OTA/AO, Haraguchi, and Mason classification. Additional radiographic data, including the length and area of posterior malleolar fragment, IAIF, and stable tibial plafond were measured. The location of IAIF was described, and involvement of the fibular notch and medial malleolus was also observed. Statistics were analyzed based on univariate analysis (Chi-square test, t-test, Mann-Whitney U test, Fisher's test) and Spearman's correlation test. RESULTS: Among the 108 cases of posterior malleolar fractures, 75 (69.4%) were with IAIF and 33 (30.6%) cases were without. There were 74 (68.5%) females and 34 (31.5%) males, and the average age of the patients was 49 years (18-89 years). The average LIFN/(LIFN + LSFN) [length of involving fibular notch/(length of involving fibular + length of stable notch fibular notch)] was 32.9% (11.6-64.9%). The APMF/(APMF + ASTP + AIAIF) [area of posterior malleolar fragment/(area of posterior malleolar fragment + area of IAIF + area of stable tibial plafond)] and AIAIF/APMF (area of IAIF/area of posterior malleolar fragment) were 13.1% (0.8-39.7%) and 52.6% (1.2-235.4%), respectively. Involvement of medial malleolus (fracture line extended to medial malleolus, P = 0.022), involvement of fibular notch (P = 0.021), LIFN/(LIFN + LSFN) (P = 0.037), LMPMF (P = 0.004), and APMF were significantly related to the occurrence of IAIF. CONCLUSION: Our research indicates a high incidence of IAIF in posterior malleolar fractures. All IAIFs were found in posterior malleolar, and the most common location was within the lateral area A. Posterior malleolar fracture lines that extend to medial malleolus or fibular notch herald the incidence of IAIF. LIFN/(LIFN + LSFN), LMPMF and APMF are also associated with the incidence of IAIF. CT scans are useful for posterior malleolar fractures to determine the occurrence of IAIF and make operational plans. Operation approach selection should be based on the morphology of posterior malleolar fragments and the location of IAIF. LEVEL OF EVIDENCE: Level III, retrospective case analysis.

4.
Materials (Basel) ; 14(24)2021 Dec 16.
Artigo em Inglês | MEDLINE | ID: mdl-34947398

RESUMO

High lead-tin bronze is widely used in the selection of wear-resistant parts such as bearings, bearing bushes, aerospace pump rotors, turbines, and guide plates because of its excellent wear resistance, thermal conductivity, fatigue resistance, and strong load-bearing capacity. At present, high lead-tin bronze is used as a material for bimetal cylinders, which cannot meet the requirements of high-strength, anti-wear in actual working conditions under high temperature, high speed, and heavy load conditions, and is prone to de-cylinder, cylinder holding, copper sticking, etc. The reason for the failure of cylinder body parts is that the strength of copper alloy materials is insufficient, the proportion of lead in the structure is serious, and the wear resistance of the material is reduced. Therefore, it has important theoretical significance and application value to carry out research on the comprehensive properties of high-performance lead-tin bronze materials and reveal the strengthening and toughening mechanism. In this paper, The ZCuPb20Sn5 alloy is taken as the main research object, and the particle size, microstructure, mechanical properties, and friction of lead particles in ZCuPb20Sn5 alloy are systematically studied after single addition of B in ZCuPb20Sn5 alloy liquid. This paper takes ZCuPb20Sn5 alloy as the research object to study the effect of adding B on the morphology, microstructure, mechanical properties, and friction and wear properties of ZCuPb20Sn5 alloy lead particles, and discusses the strengthening and toughening mechanism of ZCuPb20Sn5 alloy under the action of B, and prepares a double high-performance lead-tin bronze alloy for metal cylinders. The main research results are as follows: The addition of B elements has an obvious refining effect on the α (Cu) equiaxed grains and lead particles in ZCuPb20Sn5 alloy. The average size of lead particles decreases from 30.0 µm to 24.8 µm as the B content increases from 0 wt.% to 0.1 wt.%. The reason for grain refinement is that B is easily concentrated at the grain boundary during the ZCuPb20Sn5 alloy solidification process, which affects the diffusion of solute atoms at the solidification interface, inhibits the grain growth, refines the grain, and hinders the sinking and homogenizes distribution between dendrites of lead; the tensile strength of the ZCuPb20Sn5 alloy improves. Relatively without B, when the addition of P is 0.1 wt.%, the tensile strength is the largest at 244.04 MPa, which enhances 13%; the maximum hardness gets 75.0 HB, which enhances 13.6%, as well as elongation get the maximum value at 17.2%. The main mechanism is that the addition of B forms a high melting point submicron Ni4B3 phase in the lead-tin bronze alloy. The Ni4B3 phase is dispersed in the matrix and strengthens the matrix. With the increase in B content (more than 0.1 wt.%), the Ni4B3 phase changes from sub-micron degree granular to micron degree block-like, and some defects such as shrinkage and porosity appear in the structure, resulting in a decrease in mechanical properties.

5.
Front Cell Infect Microbiol ; 11: 706970, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34926314

RESUMO

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can cause gastrointestinal symptoms in the patients, but the role of gut microbiota in SARS-CoV-2 infection remains unclear. Thus, in this study, we aim to investigate whether SARS-CoV-2 infection affects the composition and function of gut microbiota. In this study, we demonstrated for the first time that significant shifts in microbiome composition and function were appeared in both SARS-CoV-2-infected asymptomatic and symptomatic cases. The relative abundance of Candidatus_Saccharibacteria was significantly increased, whereas the levels of Fibrobacteres was remarkably reduced in SARS-CoV-2-infected cases. There was one bacterial species, Spirochaetes displayed the difference between patients and asymptomatic cases. On the genus level, Tyzzerella was the key species that remarkably increased in both symptomatic and asymptomatic cases. Analyses of genome annotations further revealed SARS-CoV-2 infection resulted in the significant 'functional dysbiosis' of gut microbiota, including metabolic pathway, regulatory pathway and biosynthesis of secondary metabolites etc. We also identified potential metagenomic markers to discriminate SARS-CoV-2-infected symptomatic and asymptomatic cases from healthy controls. These findings together suggest gut microbiota is of possible etiological and diagnostic importance for SARS-CoV-2 infection.


Assuntos
COVID-19 , Disbiose , Humanos , Metagenoma , Metagenômica , SARS-CoV-2
6.
CNS Neurosci Ther ; 2021 Nov 02.
Artigo em Inglês | MEDLINE | ID: mdl-34729936

RESUMO

AIMS: Peripheral nerve injury is a significant clinical problem with a substantial impact on quality of life, for which no optimal treatment has been found. This study aimed to analyze the effect and mechanism of Wnt5a-loaded fibrin hydrogel on a 10-mm rat sciatic nerve defect. METHODS: The Wnt5a-loaded fibrin hydrogel was synthesized by mixing a Wnt5a solution with thrombin and fibrinogen solutions. The loading capacity and release profile of Wnt5a-loaded fibrin hydrogel and the effect of Wnt5a on Schwann cells were evaluated in vitro. We also assessed the in vivo repair status via histological analysis of the regenerative nerve and gastrocnemius muscle, electrophysiological examination, gait analysis, and muscle wet weight. RESULTS: We developed a nerve conduit filled with Wnt5a-loaded fibrin hydrogel (Fn) as a sustained-release system to repair a 10-mm rat sciatic nerve defect. In vitro, Wnt5a could promote SC proliferation and the gene expression of vascular endothelial growth factor (VEGF), nerve growth factor (NGF), and cholinergic neurotrophic factor (CNTF), as well as the protein secretion of VEGF and NGF. In vivo, the Wnt5a/Fn group was superior to the hollow, fibrin hydrogel, and Wnt5a groups in terms of axonal growth, myelination, electrophysiological recovery, target organ innervation, and motor function recovery 12 weeks after the operation. CONCLUSION: The Wnt5a/Fn nerve conduit can promote peripheral nerve defect regeneration, with potential clinical applications. The mechanism for this may be the facilitation of multiple neurotrophin secretion, combining vascularization and neurotrophic growth cues.

7.
Biomater Sci ; 9(24): 8221-8234, 2021 Dec 07.
Artigo em Inglês | MEDLINE | ID: mdl-34739533

RESUMO

Peripheral nerve injury (PNI) remains an unresolved challenge in the medicine area. With the development of biomaterial science and tissue engineering, a variety of nerve conduits were widely applied for repairing long defect PNI. DNA materials are developing rapidly due to their multiple advantages. In the present study, we aim to combine a DNA hydrogel, vascular endothelial growth factor (VEGF) and nerve growth factor (NGF) to construct a new type of delivery system, which could achieve a biphasic release profile of VEGF and NGF by taking advantage of the different degradation rates between X- and T-type DNA. In vitro results showed that the DNA gel + VEGF/NGF system could promote proliferation, migration and myelination of Rat Schwann cells (RSC) while maintaining cell viability. In vivo results indicated a better effect of DNA gel + VEGF/NGF on promoting repair of long defect PNI than the hollow chitin conduits (CT), DNA gel or VEGF/NGF group. The new technology invention holds promising clinical application prospects for repairing PNI and may be used broadly after step-by-step improvement.

8.
Chem Biol Interact ; 351: 109746, 2021 Nov 13.
Artigo em Inglês | MEDLINE | ID: mdl-34780792

RESUMO

Human aldo-keto reductase family 1C1 (AKR1C1) is an important enzyme involved in human hormone metabolism, which is mainly responsible for the metabolism of progesterone in the human body. AKR1C1 is highly expressed and has an important relationship with the occurrence and development of various diseases, especially some cancers related to hormone metabolism. Nowadays, many inhibitors against AKR1C1 have been discovered, including some synthetic compounds and natural products, which have certain inhibitory activity against AKR1C1 at the target level. Here we briefly reviewed the physiological and pathological functions of AKR1C1 and the relationship with the disease, and then summarized the development of AKR1C1 inhibitors, elucidated the interaction between inhibitors and AKR1C1 through molecular docking results and existing co-crystal structures. Finally, we discussed the design ideals of selective AKR1C1 inhibitors from the perspective of AKR1C1 structure, discussed the prospects of AKR1C1 in the treatment of human diseases in terms of biomarkers, pre-receptor regulation and single nucleotide polymorphisms, aiming to provide new ideas for drug research targeting AKR1C1.

9.
Cogn Neurodyn ; 15(6): 987-997, 2021 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-34790266

RESUMO

This study aimed to find a good coupling feature extraction method to effectively analyze resting state EEG signals (rsEEG) of amnestic mild cognitive impairment(aMCI) with type 2 diabetes mellitus(T2DM) and normal control (NC) with T2DM. A method of EEG signal coupling feature extraction based on weight permutation conditional mutual information (WPCMI) was proposed in this research. With the WPCMI method, coupling feature strength of two time series in Alpha1, Alpha2, Beta1, Beta2 and Gamma bands for aMCI with T2DM and NC with T2DM could be extracted respectively. Then selected three frequency bands coupling feature matrix with the help of multi-spectral image transformation method to map it as spectral image characteristics. And finally classified these characteristics through the convolution neural network method(CNN). For aMCI with T2DM and NC with T2DM, the highest classification accuracy of 96%, 95%, 95% could be achieved respectively in the combination of three frequency bands (Alpha1, Alpha2, Gamma), (Beta1, Beta2 and Gamma) and (Alpha2, Beta1, Beta2). This WPCMI method highlighted the coupling dynamic characteristics of EEG signals, and its classification performance was better than all previous methods in aMCI with T2DM diagnosis field. WPCMI method could be used as an effective biomarker to distinguish EEG signals of aMCI with T2DM and NC with T2DM. The coupling feature extraction method used in this paper provided a new perspective for the EEG analysis of aMCI with T2DM.

10.
Chin J Traumatol ; 2021 Aug 12.
Artigo em Inglês | MEDLINE | ID: mdl-34509352

RESUMO

Intertrochanteric fractures have become a severe public health problem in elderly patients. Proximal femoral nail anti-rotation (PFNA) is a commonly used intramedullary fixation device for unstable intertrochanteric fractures. Pelvic perforation by cephalic screw is a rare complication. We reported an 84-year-old female who fell at home and sustained an intertrochanteric fracture. The patient underwent surgery with PFNA as the intramedullary fixation device. Routine postoperative examination revealed medial migration of the helical blade that eventually caused pelvic perforation. We performed a cemented total hip arthroplasty as the savage procedure. At the latest follow-up 12 months after total hip arthroplasty, the patient had no pain or loosening of the prosthesis in the left hip. Pelvic perforation should be considered when choosing PFNA as the intramedullary fixation device, especially in patients with severe osteoporosis wherein the helical blade can be easily inserted during the operation. The lack of devices to avoid oversliding of the helical blade in PFNA is an unreported cause of this complication and should be considered in such cases.

11.
Front Genet ; 12: 728563, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34567079

RESUMO

Bone mineral density (BMD) is a complex and highly hereditary trait that can lead to osteoporotic fractures. It is estimated that BMD is mainly affected by genetic factors (about 85%). BMD has been reported to be associated with both common and rare variants, and numerous loci related to BMD have been identified by genome-wide association studies (GWAS). We systematically integrated expression quantitative trait loci (eQTL) data with GWAS summary statistical data. We mainly focused on the loci, which can affect gene expression, so Summary data-based Mendelian randomization (SMR) analysis was implemented to investigate new genes and loci associated with BMD. We identified 12,477 single-nucleotide polymorphisms (SNPs) regulating 564 genes, which are associated with BMD. The genetic mechanism we detected could make a contribution in the density of BMD in individuals and play an important role in understanding the pathophysiology of cataclasis.

12.
Hum Vaccin Immunother ; : 1-7, 2021 Sep 14.
Artigo em Inglês | MEDLINE | ID: mdl-34520323

RESUMO

BACKGROUND: In mainland China, HPV vaccines have been available to the public. However, only a few related studies among health care providers, as the key information providers, were reported although public concerns on HPV vaccines still exist. In this study, we aim to assess the knowledge of HPV, its vaccines, and attitudes toward HPV vaccines among the three most important groups of health care providers in Western China. METHOD: This was a cross-sectional questionnaire-based study. Health care providers including obstetrician-gynecologists (OB-GYNs), pediatricians, and immunization service providers in Western China were investigated regarding their knowledge of HPV and its vaccines and their attitudes toward HPV vaccines. RESULTS: Of 1079 health care providers completing the survey, 1015 (94.1%) knew HPV infection is the primary cause of cervical cancer. However, lower knowledge levels of other HPV-related diseases were also found (43.2%). About three-quarters (74.1%) of practitioners interviewed would be willing to recommend HPV vaccination, which was found to be lower among the OB-GYNs (69.6%) and the pediatricians (73.2%). "Lack of relevant knowledge," "concerns on safety and efficacy" and price were the three most important concerns surrounding HPV vaccination. CONCLUSION: The interviewed practitioners did not have adequate knowledge of HPV and its vaccines in depth. Education interventions are highly recommended to the health care providers, especially for OB-GYNs and pediatricians, to increase the coverage of HPV vaccination among the population. For the currently high price of vaccines, a future co-sharing mechanism between the government, the providers, and the individuals might be a solution.

13.
Nanoscale ; 13(38): 16277-16287, 2021 Oct 08.
Artigo em Inglês | MEDLINE | ID: mdl-34549748

RESUMO

Developing cost-effective, highly-active and robust electrocatalysts is of vital importance to supersede noble-metal ones for both hydrogen evolution reactions (HERs) and oxygen reduction reactions (ORRs). Herein, a unique vanadium-mediated space confined strategy is reported to construct a composite structure involving Co/Co9S8 nanoparticles anchored on Co-N-doped porous carbon (VCS@NC) as bifunctional electrocatalysts toward HER and ORR. Benefitting from the ultrafine nanostructure, abundant Co-Nx active sites, large specific surface area and defect-rich carbon framework, the resultant VCS@NC exhibits unexceptionable HER catalytic activity, needing extremely low HER overpotentials in pH-universal media (alkaline: 117 mV, acid: 178 mV, neutral: 210 mV) at a current density of 10 mA cm-2, paralleling at least 100 h catalytic durability. Notably, the VCS@NC catalyst delivers high-efficiency ORR performance in alkaline solution, accompanied with a quite high half wave potential of 0.901 V, far overmatching the commercial Pt/C catalyst. Our research opens up novel insight into engineering highly-efficient multifunctional non-precious metal electrocatalysts by a metal-mediated space-confined strategy in energy storage and conversion system.

14.
Artigo em Inglês | MEDLINE | ID: mdl-34535393

RESUMO

BACKGROUND AND OBJECTIVE: Studies have reported an increased tuberculosis (TB) incidence among patients with end-stage renal disease (ESRD). This nationwide nested Case-control study investigated the risk of active TB due to nosocomial exposure and its correlation with the delay in TB treatment in hemodialysis patients. METHODS: Adult (aged ≥20 years) patients with incident ESRD over 2000-2010 were identified from Taiwan National Health Insurance Research Database; 2331 patients with incident active TB (Case) were matched with 11,655 patients without TB (control) by age, sex, year of ESRD onset, Charlson comorbidity index, chronic obstructive pulmonary disease, and diabetes mellitus, at a 1:5 case-to-control ratio. RESULTS: Compared with the control group, the Case group had greater nosocomial exposure to index patients with pulmonary TB (2.36 vs. 0.11 month of exposure, p < 0.001). Nosocomial exposure increased active TB risk (adjusted odds ratio [OR; 95% confidence interval, CI]: 1.60 [1.55-1.66] per month of exposure), particularly when the exposure time was either within 6 months before the index case was diagnosed or 6-15 months before the ESRD patient became an incident active TB case. For patients with active TB, cough-related medication prescriptions (proxy for cough symptoms) exponentially increased over 6 months before TB treatment. CONCLUSION: Nosocomial exposure attributed to delay in the diagnosis of index pulmonary TB is important in TB transmission among patients undergoing regular hemodialysis. Additional studies investigating how TB can be diagnosed and treated early are warranted. SUMMARY AT A GLANCE: Our study revealed that nosocomial exposure, attributed to delay in pulmonary TB diagnosis, is important in TB transmission among patients undergoing regular hemodialysis. Strategies to diagnose and treat TB early are crucial to infection control, and they warrant further investigations.

15.
J Nanobiotechnology ; 19(1): 234, 2021 Aug 06.
Artigo em Inglês | MEDLINE | ID: mdl-34362405

RESUMO

BACKGROUND: Pregnancy exposure to titanium dioxide nanoparticles (TiO2NPs) is a vital consideration due to their inadvertent ingestion from environmental contamination. The potential health effects of TiO2NPs on the neurodevelopmental process should be seriously concerned in health risk assessment, especially for the pregnant women who are susceptible to the neurodevelopmental toxicity of nano-sized particles. However, the available evidence of neurodevelopmental toxicity of TiO2NPs remains very limited. METHODS: In the present study, the pregnant mice were intragastric administered with 150 mg/kg TiO2NPs from gestational day (GD) 8 to 21, the maternal behaviors and neurodevelopment-related indicators in offspring were all assessed at different time points after delivery. The gut microbial community in both dams and their offspring were detected by using 16S ribosomal RNA (rRNA) gene sequencing. The gut-brain axis related indicators were also determined in the offspring. RESULTS: The results clearly demonstrated that exposure to TiO2NPs did not affect the maternal behaviors of pregnant mice, or cause the deficits on the developmental milestones and perturbations in the early postnatal development of offspring. Intriguingly, our data revealed that pregnancy exposure of TiO2NPs did not affect locomotor function, learning and memory ability and anxiety-like behavior in offspring at postnatal day (PD) 21, but resulted in obvious impairments on these neurobehaviors at PD49. Similar phenomena were obtained in the composition of gut microbial community, intestinal and brain pathological damage in offspring in adulthood. Moreover, the intestinal dysbiosis induced by TiO2NPs might be highly associated with the delayed appearance of neurobehavioral impairments in offspring, possibly occurring through disruption of gut-brain axis. CONCLUSIONS: This is the first report elucidated that pregnancy exposure to TiO2NPs caused delayed appearance of neurobehavioral impairments in offspring when they reached adulthood, although these perturbations did not happen at early life after delivery. These findings will provide valuable insights about neurodevelopmental toxicity of TiO2NPs, and call for comprehensive health risk assessment of TiO2NPs on the susceptible population, such as pregnant women.

16.
Dalton Trans ; 50(33): 11604-11609, 2021 Sep 07.
Artigo em Inglês | MEDLINE | ID: mdl-34355722

RESUMO

Designing cost-effective bifunctional catalysts with high-performance and durability is of great significance for renewable energy systems. Herein, typical Fe, Ni-codoped W18O49/NF was prepared via a simple solvothermal method. The incorporation of Fe ions enhanced the electronic interaction and enlarged the electrochemically active surface area. The increased W4+ leads to a high proportion of unsaturated W[double bond, length as m-dash]O bonds, thus enhancing the adsorption capacity of water. The valence configuration of nickel (Ni) sites in such dual-cation doping is well adjusted, realizing a high proportion of trivalent Ni ions (Ni3+). Due to the orbital interactions, the Fe3+/Ni3+ ions and OER reaction intermediates exhibit strong orbital overlap. The positions of the valence band and conduction band are well modulated. As a result, the Fe, Ni-codoped W18O49/NF shows improved electrocatalytic activity, and achieves a low decomposition voltage of 1.58 V at 10 mA cm-2 and retains long-time stability.

17.
Artigo em Inglês | MEDLINE | ID: mdl-34196772

RESUMO

INTRODUCTION: An intra-articular impacted fragment (IAIF) could lead to articular incongruity and malreduction in ankle fractures with posterior malleolar fractures (PMFs). No studies have been conducted to determine whether the presence of IAIF affects the outcome of ankle fractures with PMF. The aim of our retrospective study was to evaluate the effect of IAIF on postoperative outcomes in PMF and analyze the relationship between area of IAIF and outcomes. MATERIALS AND METHODS: We conducted a retrospective study of patients with a posterior malleolar fractures between June 2012 and January 2019 with a minimum follow-up of 2 years. Results of the Olerud-Molander ankle score (OMAS), EuroQol-5D (EQ-5D) index, EQ-5D visual analog scale (VAS), AOFAS (American orthopedic foot and ankle society ankle-hindfoot scale), visual analog scale (VAS) pain score and overall patient satisfaction scale were recorded. Outcomes of the PMF with IAIF group and PMF without IAIF group were compared. Sub-group analysis was given emphasis on the AIAIF > 40 mm2 group and AIAIF < 40 mm2 group in PMF with IAIF. RESULTS: A total of 128 patients were included in the study, consisting of 86 patients with IAIF and 42 patients without IAIF. Regarding the osteoarthritis grade (> 1, ≤ 1), the differences werestatistically significant between the two groups (P = 0.044). The risk of articular malreduction was higher in the PMF with IAIF group than in the PMF without IAIF group (P = 0.035). Osteoarthritis grade (> 1, ≤ 1) was closely related to articular malreduction (P < 0.001). There were 51 patients in the AIAIF > 40 mm2 group and 35 patients in the AIAIF < 40 mm2 group of 86 patients in PMF with IAIF. There were statistically significant differences in trimalleolar fracture (P = 0.004), malreduction (P = 0.022), osteoarthritis grade (> 1, ≤ 1; P = 0.027), EQ-5D VAS score (P = 0.031), and AOFAS score (P = 0.047) between the subgroups. CONCLUSION: The incidence of IAIF is associated with the area of the posterior malleolar fragment. Articular malreduction can lead to post-traumatic osteoarthritis, while IAIF is an important element for the quality of reduction, which is more likely to lead to articular malreduction. IAIF should be reduced if AIAIF is over 40 mm2. Otherwise, the patient will suffer a poor prognosis and post-traumatic osteoarthritis. Therefore, ankle fractures with PMF should undergo a CT scan preoperatively in order for providers to optimal treatment protocols. LEVEL OF EVIDENCE: Level III.

18.
Cancer Lett ; 520: 172-183, 2021 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-34265399

RESUMO

The UHRF1 and CDC6, oncogenes play critical roles in therapeutic resistance. In the present study, we found that UHRF1 mediates androgen receptor (AR)-regulated CDC6 transcription in prostate cancer cells. In prostate cancer tissues and cell lines, levels of UHRF1 and CDC6 were simultaneously upregulated, and this was associated with worse survival. UHRF1 silencing significantly promoted the cytotoxicity and anti-prostate cancer efficacy of bicalutamide in mouse xenografts by inhibiting CDC6 gene expression. UHRF1 promoted AR-regulated CDC6 transcription by binding to the CCAAT motif near the androgen response element (ARE) in the CDC6 promoter. We further found that UHRF1 promoted androgen-dependent chromatin occupancy of AR protein by recruiting the H3K9me2/3-specific demethyltransferase KDM4C and modifying the intense heterochromatin status. Altogether, we found for the first time that UHRF1 promotes AR-regulated CDC6 transcription through a novel chromatin modification mechanism and contributes to anti-AR drug resistance in prostate cancer. Targeting AR and UHRF1 simultaneously may be a novel and promising therapeutic modality for prostate cancer.

19.
Artigo em Inglês | MEDLINE | ID: mdl-34291410

RESUMO

Concomitant with the promotion of industrial transformation, sustainable development strategies, and accelerated urbanization, there has been an increase in the number of industrial relic restoration projects. However, there are many disputes over the value and development of such industrial relic restoration projects. In this work, we identified three evaluation indicators based on a study of 106 industrial relic restoration projects in China. A value assessment model composed of five parts combining the Delphi method and analytic hierarchy process was established. The results show that an effective assessment of the value of industrial relic restoration projects can enable the effective use of green technology, reduce construction costs, protect industrial heritage, and inherit historical culture. In addition, there are many uncertain factors in developing these projects, such as brownfield pollution and dilapidated buildings, and appropriate renewal strategies can reduce safety risks as well as maximize the heritage value. As there is limited research assessing the value of industrial relic restoration projects in China, our study can serve as a reference for the value assessment of existing building restoration projects including historical blocks and livable villages.

20.
PLoS One ; 16(7): e0254372, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34292979

RESUMO

China is currently designing a regional economic layout for high-quality urban development, shifting its focus from the primary stage of beautifying cities to the next stage of profound urbanization aiming at strengthening industry. This is of high importance given that the urbanization rate of permanent residents by the end of 2019 was 60.60%, according to the National Bureau of Statistics of China. In the face of various factors such as the need to economize the intensive use of resources, urban stock development, and the need for urban constructions to maintain harmony with the surrounding ecosystem, regeneration has emerged as an efficient means to repurpose old residential districts. It conforms to the policy of stock planning and is one of the important methods to ensure the sustainable development of a city. Prioritizing the right attributes in renovation is one of the critical steps in the regeneration of old residential districts-instead of merely focusing on their selection and scoring by experts, more attention should be paid to the resident satisfaction (or the lack thereof) arising from them. Therefore, in this study, we have proposed a collaborative approach that requires communities to prioritize the appropriate aspects in urban renewal. This study employed the three-factor theory of customer satisfaction, to investigate the five attributes namely geographical location, infrastructure, traffic, residential management, and living facilities, of satisfaction and dissatisfaction of residents in the old city. This includes 327 samples based on the residents of Yanta old town in Xi'an. The asymmetric impact-performance analysis technique was used to explore, and quantify the asymmetric relationship between the attributes of old residential districts, and residents' satisfaction. The results proved that attributes were divided into three: excitement factors, performance, and basic factors, based on the asymmetric influence of attributes on residents' satisfaction. Residential management was into excitement factors, living facilities were categorized into basic factors, and the remaining three attributes were categorized into performance factors. The satisfaction of the residents regarding the renovation was maximized by comprehensively considering the performance of given attributes, adjusting the improvement strategies of each attribute, and further determining the focus of the renovation of the old residential districts. Simultaneously, it helped planners make more rational choices in urban renewal and sustainable development.


Assuntos
Satisfação Pessoal , Reforma Urbana , Urbanização , China , Cidades , Humanos
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