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1.
J Environ Sci (China) ; 125: 266-276, 2023 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-36375913

RESUMO

An increasing divergence regarding fuel consumption (and/or CO2 emissions) between real-world and type-approval values for light-duty gasoline vehicles (LDGVs) has posed severe challenges to mitigating greenhouse gases (GHGs) and achieving carbon emissions peak and neutrality. To address this divergence issue, laboratory test cycles with more real-featured and transient traffic patterns have been developed recently, for example, the China Light-duty Vehicle Test Cycle for Passenger cars (CLTC-P). We collected fuel consumption and CO2 emissions data of a LDGV under various conditions based on laboratory chassis dynamometer and on-road tests. Laboratory results showed that both standard test cycles and setting methods of road load affected fuel consumption slightly, with variations of less than 4%. Compared to the type-approval value, laboratory and on-road fuel consumption of the tested LDGV over the CLTC-P increased by 9% and 34% under the reference condition (i.e., air conditioning off, automatic stop and start (STT) on and two passengers). On-road measurement results indicated that fuel consumption under the low-speed phase of the CLTC-P increased by 12% due to the STT off, although only a 4% increase on average over the entire cycle. More fuel consumption increases (52%) were attributed to air conditioning usage and full passenger capacity. Strong correlations (R2 > 0.9) between relative fuel consumption and average speed were also identified. Under traffic congestion (average speed below 25 km/hr), fuel consumption was highly sensitive to changes in vehicle speed. Thus, we suggest that real-world driving conditions cannot be ignored when evaluating the fuel economy and GHGs reduction of LDGVs.


Assuntos
Poluentes Atmosféricos , Gasolina , Gasolina/análise , Emissões de Veículos/análise , Automóveis , Dióxido de Carbono/análise , Poluentes Atmosféricos/análise , Veículos Automotores
2.
J Colloid Interface Sci ; 629(Pt A): 478-486, 2023 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-36088693

RESUMO

Novel phase change materials composed of polyethylene glycol (PEG), cellulose nanofibers (CNFs) and carbon nanotubes (CNTs) were developed by an efficient and environment friendly strategy. The CNFs were modified and cross-linked by chitosan to form three-dimensional network structure, which provides strong support for the resulting CNF/CNT/PEG composites. The structure and properties of CNF/CNT/PEG composites were characterized using scanning electron microscopy, spectrums, and differential scanning calorimeter. They exhibit high latent heat (158.3 J/g), low heat loss (0.75%) and excellent photo-thermal conversion (energy storage efficiency 85.6%), electro-thermal conversion (energy storage efficiency 92.3%) properties. Due to their excellent performances, CNF/CNT/PEG composites have great potential to be used as thermal management materials.


Assuntos
Quitosana , Nanofibras , Nanotubos de Carbono , Nanofibras/química , Celulose/química , Nanotubos de Carbono/química , Polietilenoglicóis
3.
J Colloid Interface Sci ; 629(Pt A): 766-777, 2023 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-36099844

RESUMO

The size of silver nanoparticles (Ag NPs) and loading amount of Ag NPs onto their substrate/carrier are two key factors for their efficient applications. Herein, we present a facile method for in situ synthesizing ultrafine and highly loaded Ag NPs on the surface of tannin-coated catechol-formaldehyde resin (TA-CFR) nanospheres. TA-CFR nanospheres act as green and highly efficient reducing agents for converting silver ions (Ag+) into Ag NPs, and the size of resultant Ag NPs is only âˆ¼ 7.5 nm, and the Ag NPs loading capacity of TA-CFR is as high as 61.5 wt%, both of which contribute to the very high specific surface area of Ag NPs. Consequently, the as-synthesized TA-CFR@Ag composites show high catalytic performance, and the catalytic rate for the reduction of 4-nitrophenol is almost 10 times higher than that of the control. Meanwhile, TA-CFR@Ag composites also possess high antibacterial activity, efficiently inhibiting the growth of Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). Furthermore, tannin coating (thickness: ∼ 15 nm) minimizes the aggregation of Ag NPs, and enhances the reusability and stability of resultant Ag NPs, because of their high surface charges (the zeta potential is up to -65.5 ± 1.9 mV) and strong coordination capability with Ag NPs. This work provides a new frontier to develop multifunctional nanomaterials focusing on the green catalyst synthesis and environmental-remedy applications.


Assuntos
Nanopartículas Metálicas , Prata , Prata/farmacologia , Antibacterianos/farmacologia , Staphylococcus aureus , Escherichia coli , Substâncias Redutoras , Catecóis , Taninos , Formaldeído , Testes de Sensibilidade Microbiana
4.
Spectrochim Acta A Mol Biomol Spectrosc ; 285: 121830, 2023 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-36179567

RESUMO

Rapid, sensitive and simultaneous detection of multiple bacteria in foodborne is still a major challenge in public health field. Here, a fluorescence immunoassay that can achieve high-throughput detection of three Gram-positive foodborne pathogenic bacteria simultaneously was proposed. Vancomycin and bovine serum albumin conjugate (Van-BSA) was immobilized on a polycarbonate chip to capture three Gram-positive foodborne pathogenic bacteria, Staphylococcus aureus (S. aureus), Bacillus cereus (B. cereus) and Listeria monocytogenes (L. monocytogenes). CdSe/ZnS quantum dot modified antibodies (Ab-QD) were prepared by carbodiimide coupling chemistry. Due to the affinity reaction between antibodies and proteins on the bacterial surface, the simultaneous detection of multiple Gram-positive bacteria was achieved by monitoring the fluorescence signal of quantum dot by a portable microfluidic chip analyzer. Under optimal conditions, low detection limits was 18 CFU/well, 3 CFU/well and 36 CFU/well for S. aureus, B. cereus and L. monocytogenes, respectively. With satisfactory accuracy and precision, the proposed fluorescence immunoassay holds good prospects to detect pathogens in real food samples.


Assuntos
Listeria monocytogenes , Infecções Estafilocócicas , Humanos , Animais , Leite , Microbiologia de Alimentos , Staphylococcus aureus , Imunoensaio
5.
J Hazard Mater ; 443(Pt A): 130156, 2023 02 05.
Artigo em Inglês | MEDLINE | ID: mdl-36252406

RESUMO

Formaldehyde scavenger microcapsules were introduced into particleboard to prepare an ecofriendly particleboard with a low pollution release in response to the problem of long-term unstable free formaldehyde release from particleboards. By analyzing key parameters of formaldehyde emission from particleboard, the effects of microcapsules on the diffusion, migration and inhibition of free formaldehyde in particleboard pore structures was discussed. The results showed that microencapsulated formaldehyde scavenger prepared by an emulsification cross-linking method with chitosan as the wall material and urea as the core material resulted in a good long-term controlled release effect on formaldehyde emission. Compared with that of the control panel, the formaldehyde emission of the particleboard with microcapsules decreased by 51.4 % and 25.8 % at 28 d and 180 d, respectively. The addition of formaldehyde scavenger microcapsules increased the particleboard macroscopic pore volume, which facilitated the conversion of adsorbed formaldehyde into free formaldehyde in the pore structure, thereby promoting its migration and diffusion in the particleboard pores. Moreover, the synergistic effect of the addition-condensation and nucleophilic cross-linking of the core and wall materials quickly captured the free formaldehyde in the panels and reduced the releasable concentration of formaldehyde in the material, thus achieving the long-term effective control of formaldehyde emission.


Assuntos
Formaldeído , Substâncias Perigosas , Cápsulas , Formaldeído/química , Ureia
6.
J Hazard Mater ; 443(Pt A): 130198, 2023 02 05.
Artigo em Inglês | MEDLINE | ID: mdl-36279648

RESUMO

Laccases are multicopper oxidases of significant importance for the degradation of phenolic pollutants. Because of the inherent defects of natural laccases in practical applications, herein, we discovered highly effective and non-cytotoxic laccase-like metallo-nanofibers based on the supramolecular assembly of single unnatural amino acid, benzophenone-alanine (BpA), in combination with copper ions. Structural analysis revealed that the catalytic BpA-Cu nanofibers possess a Cu(I)-Cu(II) electron transfer system similar to that in natural laccase. Our BpA-Cu nanofibers exhibit 4 times higher substrate affinity and 24% higher catalytic efficiency than the well-known high-performance industrialized laccase (Novozym 51003) in 2,4-dichlorophenol degradation. In addition, the BpA-Cu nanofibers were demonstrated to be stable (>75% residual activity) in long-term storage at a wide range of pH, ionic strength, temperature, ethanol, and water sample, and to be readily recovered for pollutant degradation, keeping 83% of the laccase activity after 10 catalytic recycles. Remarkably, the nanofibers displayed a wide substrate spectrum, detecting and degrading a variety of phenolic pollutants with high activity than other laccase mimics reported in the literature. Furthermore, the biocompatibility of the material was proved with cultured cells. These findings demonstrated the potential of BpA-Cu nanofibers in mimicking laccases for environmental remediation.


Assuntos
Poluentes Ambientais , Lacase , Lacase/metabolismo , Cobre/química , Alanina , Fenóis/química , Benzofenonas
7.
J Colloid Interface Sci ; 630(Pt B): 559-569, 2023 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-36335775

RESUMO

Designing efficient, stable, and low-cost bifunctional catalysts for overall water splitting is significant but challenging. In this work, Zn and F ions co-doped NiCoP nanoprism arrays grown directly on nickel foam (Zn/F-NiCoP/NF) was synthesized via hydrothermal method followed by phosphorization treatment. The resultant Zn/F-NiCoP/NF exhibits high electrocatalytic activity towards hydrogen evolution reaction (HER, η10 = 59 mV) and oxygen evolution reaction (OER, η50 = 285 mV). An alkaline electrolyzer using Zn/F-NiCoP/NF as both cathode and anode requires a low cell voltage of 1.568 V at a current density of 10 mA cm-2 with a high long-term stability of up to 40 h, which outperforms many reported Ni,Co-based catalysts. Density functional theory (DFT) calculations proof that simultaneous doping of NiCoP with Zn and F ions provides flexibility to regulate the electronic configuration and downshifts the transition metal d-band center, thereby optimizing adsorption energy between reactants and intermediates, which enhances the HER and OER catalytic activities. This work highlights that cation-anion co-doping strategy is an effective way to develop highly active transition metal phosphides electrocatalyst for water splitting.

8.
Sci Total Environ ; 855: 158956, 2023 Jan 10.
Artigo em Inglês | MEDLINE | ID: mdl-36150598

RESUMO

Nitrate is a common pollutant in the aquatic environment. Denitrification and dissimilatory nitrate reduction to ammonium (DNRA) are the main reduction processes of nitrate. In the relatively closed sediment environment, the competitive interaction of these two nitrate reduction determines whether the ecosystem removes or retains nitrogen. In the process of NO3--N bioreduction, Magnetite, which is a common mineral present in soil and other sediments can play a crucial role. However, it is still not clear whether magnetite promotes or inhibits NO3--N bioreduction. In this paper, the effect of magnetite on NO3--N bioreduction was studied by batch experiments. The results show that magnetite can increase the NO3--N reduction rate by 1.48 %, and can inhibit the DNRA process at the beginning of the reaction and then promote the DNRA process. Magnetite changed the microbial community structure in our experiment systems. The relative abundance of Sphingomonas, which mainly exists in a high carbon and low nitrogen environment, increased under sufficient carbon source conditions. The relative abundance of Fe-oxidizing and NO3--N reducing bacteria, such as Flavobacterium, increased in the absence of carbon sources but in the presence of magnetite. In addition, magnetite can significantly increase activity of the microbial electron transport system (ETS). the added microbial electronic activity of magnetite increased nearly two-fold under the same experiment conditions. The acid produced by the metabolisms of Pseudomonas and Acinetobacter further promotes the dissolution of magnetite, thus increasing the concentration of Fe (II) in the system, which is beneficial to autotrophic denitrifying bacteria and promote the reduction of NO3--N. These findings can enhance our understanding of the interaction mechanism between iron minerals and nitrate reducing bacteria during nitrate reduction under natural conditions.


Assuntos
Compostos de Amônio , Água Subterrânea , Microbiota , Nitratos/análise , Desnitrificação , Óxido Ferroso-Férrico , Compostos de Amônio/metabolismo , Óxidos de Nitrogênio/metabolismo , Nitrogênio/metabolismo , Carbono/metabolismo , Bactérias/metabolismo , Oxirredução
9.
Neural Regen Res ; 18(4): 708-715, 2023 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-36204826

RESUMO

Alzheimer's disease is characterized by sustained neuroinflammation leading to memory loss and cognitive decline. The past decade has witnessed tremendous efforts in Alzheimer's disease research; however, no effective treatment is available to prevent disease progression. An increasing body of evidence suggests that neuroinflammation plays an important role in Alzheimer's disease pathogenesis, alongside the classical pathological hallmarks such as misfolded and aggregated proteins (e.g., amyloid-beta and tau). Firstly, this review summarized the clinical and pathological characteristics of Alzheimer's disease. Secondly, we outlined key aspects of glial cell-associated inflammation in Alzheimer's disease pathogenesis and provided the latest evidence on the roles of microglia and astrocytes in Alzheimer's disease pathology. Then, we revealed the double-edged nature of inflammatory cytokines and inflammasomes in Alzheimer's disease. In addition, the potential therapeutic roles of innate immunity and neuroinflammation for Alzheimer's disease were also discussed through these mechanisms. In the final section, the remaining key problems according to the current research status were discussed.

10.
Food Chem ; 398: 133931, 2023 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-35986992

RESUMO

A comprehensive UPLC-MS/MS-based lipidomics analysis of egg yolk at different storage periods was performed. Through the analysis, 836 lipid species from 27 subclasses were detected, including 159 significantly different lipid species. Glycerolipids (GL) and glycerophospholipids (GP) were the most abundant lipids, followed by fatty acyls (FA), sphingolipids (SP), sterol lipids (ST), and prenol lipids (PR). PCA and OPLS-DA showed that egg yolk lipids changed significantly with prolonged storage. Moreover, glycerophospholipid metabolism and glycerolipid metabolism were key metabolic pathways, as phosphatidic acid (PA), lysophosphatidic acid (LPA), and diglyceride (DG) were key lipid metabolites in the related metabolic pathways of egg yolk during storage. Furthermore, egg yolk quality changed the most when stored up to 21 days. Our study establishes a foundation for the quality control and the lipid oxidation mechanism of eggs during storage.


Assuntos
Gema de Ovo , Lipidômica , Cromatografia Líquida de Alta Pressão , Cromatografia Líquida , Lipídeos , Espectrometria de Massas em Tandem
11.
Food Chem ; 400: 134055, 2023 Jan 30.
Artigo em Inglês | MEDLINE | ID: mdl-36075164

RESUMO

The structural foundation of texture changes in sea cucumber body wall (SCBW) during boiling was investigated using second harmonic generation (SHG) microscopy for the first time. The results from SHG signal imaging, light microscopy, scanning electron microscopy and transmission electron microscopy indicated the hierarchical structures of collagen in SCBW underwent progressive destruction with the prolongation of boiling time, including the depolymerization of collagen fibres, the uncoiling and disaggregation of collagen fibrils, the destruction of collagen microfibrils, the loosing of triple helix structure of collagen, and the degradation and gelatinization of collagen, which contributed to the progressive decline in texture indicators including shear force and hardness. SHG analysis also indicated that although collagen macromolecules such as collagen fibres, collagen fibrils and collagen microfibrils could be observed in 0.5 h-boiled and 2 h-boiled SCBW, monomeric collagen, the basic structural components of those macromolecules, has been already damaged.


Assuntos
Pepinos-do-Mar , Microscopia de Geração do Segundo Harmônico , Animais , Colágeno/química , Microscopia Eletrônica de Varredura , Microscopia Eletrônica de Transmissão , Pepinos-do-Mar/química
12.
Chemosphere ; 311(Pt 1): 137039, 2023 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-36342026

RESUMO

Limited information is available on the links between heavy metals' exposure and coronary heart disease (CHD). We aim to establish an efficient and explainable machine learning (ML) model that associates heavy metals' exposure with CHD identification. Our datasets for investigating the associations between heavy metals and CHD were sourced from the US National Health and Nutrition Examination Survey (US NHANES, 2003-2018). Five ML models were established to identify CHD by heavy metals' exposure. Further, 11 discrimination characteristics were used to test the strength of the models. The optimally performing model was selected for identification. Finally, the SHapley Additive exPlanations (SHAP) tool was used for interpreting the features to visualize the selected model's decision-making capacity. In total, 12,554 participants were eligible for this study. The best performing random forest classifier (RF) based on 13 heavy metals to identify CHD was chosen (AUC: 0.827; 95%CI: 0.777-0.877; accuracy: 95.9%). SHAP values indicated that cesium (1.62), thallium (1.17), antimony (1.63), dimethylarsonic acid (0.91), barium (0.76), arsenous acid (0.79), total arsenic (0.01) in urine, and lead (3.58) and cadmium (4.66) in blood positively contributed to the model, while cobalt (-0.15), cadmium (-2.93), and uranium (-0.13) in urine negatively contributed to the model. The RF model was efficient, accurate, and robust in identifying an association between heavy metals' exposure and CHD among US NHANES 2003-2018 participants. Cesium, thallium, antimony, dimethylarsonic acid, barium, arsenous acid, and total arsenic in urine, and lead and cadmium in blood show positive relationships with CHD, while cobalt, cadmium, and uranium in urine show negative relationships with CHD.


Assuntos
Arsênio , Doença das Coronárias , Poluentes Ambientais , Metais Pesados , Urânio , Adulto , Humanos , Inquéritos Nutricionais , Cádmio/urina , Antimônio , Exposição Ambiental/análise , Bário , Tálio , Cobalto/urina , Césio , Doença das Coronárias/epidemiologia , Aprendizado de Máquina
13.
Sci Total Environ ; 856(Pt 2): 159175, 2023 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-36191702

RESUMO

As an emerging green wastewater treatment technology, the microalgal-bacterial granular sludge (MBGS) process has attracted increasing interest under the current situation of global climate change. However, little information is available for its performance in treating municipal wastewater under outdoor conditions. Thus, this study evaluated the behaviors of MBGS for treating simulated and real municipal wastewater under natural diel conditions. The results showed that a significant accumulation of oxygen bubbles during daily operation led to the auto-floating of the conventional settable MBGS. The removal of organics was relatively stable during day-night cycles, while the removals of total nitrogen and total phosphorus were dependent on the saturated oxygen concentration over 10 mg/L in MBGS system. Furthermore, oxygen bubbles generated by photosynthesis of microalgae (Scenedesmaceae and Cyanobacteria) due to microalgae phototaxis were found to be attached onto the surface of granules, causing the auto-flotation of MBGS. The formation process of the auto-floating oxygenic MBGS was clarified and further analysis suggested that the non-aerated settable MBGS would be able to auto-float at an average outdoor light intensity of 140 µ mol/m2/s. Overall, the auto-floating oxygenic MBGS process was demonstrated to be feasible for real municipal wastewater treatment, even under rainy and cloudy days, advancing the knowledge and adding theoretical basis for its further applications.


Assuntos
Microalgas , Esgotos , Águas Residuárias/análise , Oxigênio/análise , Fósforo , Nitrogênio/análise , Reatores Biológicos
14.
J Colloid Interface Sci ; 631(Pt A): 143-154, 2023 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-36371823

RESUMO

Improving the lifetime and energy density of energy storage devices has always been a major challenge. Here, CoS2 with a hollow structure derived from zeolite-imidazolate framework-67 was reconstructed on Co(OH)F nanowires. Co(OH)F nanowires contribute to ion/electron transmission and reduce transmission resistance, thereby promoting the stability of the electrode. CoS2 with a hollow porous structure contributes to the full infiltration of electrolytes, shortens the ion transmission distance, accelerates the redox reactions, and alleviates the volume expansion, thus improving the pseudocapacitance. Therefore, the prepared Co(OH)F/CoS2 displayed excellent specific capacity (233 mAh g-1). The assembled HSC Co(OH)F/CoS2//activated carbon in KOH solution could achieve a considerable energy density (63.9 Wh kg-1). Surprisingly, the specific capacitance accounts for 107.0% of the primary capacitance (20,000 cycles), demonstrating great cycling stability. This work presents a conceptual approach for the construction of abundant and promising electrodes for HSCs.

15.
J Surg Res ; 281: 264-274, 2023 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-36219938

RESUMO

INTRODUCTION: Persistent lung inflammation is a characteristic of sepsis-induced lung injury. Matrine, the active ingredient from Sophora flavescens, has exhibited anti-inflammatory activities. This study investigated the effects of prophylactic administration of matrine on macrophage polarization, apoptosis, and tissue injury in a cecal ligation and puncture (CLP)-induced murine lung injury model. METHODS: Mice were randomly allocated into four groups: Sham, CLP, Sham + Matrine, and CLP + Matrine. Lung tissues were collected at 24 h post-CLP. Histopathology and immunofluorescence analysis were performed to evaluate lung injury and macrophage infiltration in the lung, respectively. Caspase-3 activities, TUNEL staining, and anti-apoptotic proteins were examined to assess apoptosis. To determine the mechanism of action of matrine, protein levels of Sirtuin 1 (SIRT1), nuclear factor κB (NF-κB), p53 and the messenger RNA levels of p53-mediated proapoptotic genes were examined to elucidate the associated signaling pathways. RESULTS: Histopathological evaluation showed that matrine prophylaxis attenuated sepsis-induced lung injury. Matrine prophylaxis attenuated sepsis-induced infiltration of the total population of macrophages in the lung. Matrine inhibited M1 macrophage infiltration, but increased M2 macrophage infiltration, thus resulting in a decrease in the proportion of M1 to M2 macrophages in septic lung. Sepsis-induced lung injury was associated with apoptotic cell death as evidenced by increases in caspase-3 activity, TUNEL-positive cells, and decreases in antiapoptotic proteins, all of which were reversed by matrine prophylaxis. Matrine restored sepsis-induced downregulation of SIRT1 and deacetylation of NF-κB p65 subunit and p53, thus inactivating NF-κB pathway and suppressing p53-induced proapoptotic pathway in septic lung. CONCLUSIONS: In summary, this study demonstrated that matrine exhibited pro-M2 macrophage polarization and antiapoptotic effects in sepsis-induced lung injury, which might be, at least partly, due to the modulation of SIRT1/NF-κB and SIRT1/p53 pathways.


Assuntos
Lesão Pulmonar , Sepse , Camundongos , Animais , Sirtuína 1/metabolismo , NF-kappa B/metabolismo , Lesão Pulmonar/complicações , Caspase 3/metabolismo , Proteína Supressora de Tumor p53 , Sepse/complicações , Sepse/tratamento farmacológico , Sepse/metabolismo , Apoptose , Macrófagos/metabolismo
16.
Bioact Mater ; 19: 690-702, 2023 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-35600978

RESUMO

Osteosarcoma (OS) therapy faces many challenges, especially the poor survival rate once metastasis occurs. Therefore, it is crucial to explore new OS treatment strategies that can efficiently inhibit OS metastasis. Bioactive nanoparticles such as zinc oxide nanoparticles (ZnO NPs) can efficiently inhibit OS growth, however, the effect and mechanisms of them on tumor metastasis are still not clear. In this study, we firstly prepared well-dispersed ZnO NPs and proved that ZnO NPs can inhibit OS metastasis-related malignant behaviors including migration, invasion, and epithelial-mesenchymal transition (EMT). RNA-Seqs found that differentially expressed genes (DEGs) in ZnO NP-treated OS cells were enriched in wingless/integrated (Wnt) and hypoxia-inducible factor-1 (HIF-1) signaling pathway. We further proved that Zn2+ released from ZnO NPs induced downregulation of ß-catenin expression via HIF-1α/BNIP3/LC3B-mediated mitophagy pathway. ZnO NPs combined with ICG-001, a ß-catenin inhibitor, showed a synergistic inhibitory effect on OS lung metastasis and a longer survival time. In addition, tissue microarray (TMA) of OS patients also detected much higher ß-catenin expression which indicated the role of ß-catenin in OS development. In summary, our current study not only proved that ZnO NPs can inhibit OS metastasis by degrading ß-catenin in HIF-1α/BNIP3/LC3B-mediated mitophagy pathway, but also provided a far-reaching potential of ZnO NPs in clinical OS treatment with metastasis.

17.
Artigo em Inglês | MEDLINE | ID: mdl-36318563

RESUMO

In recent years a vast amount of visual content has been generated and shared from many fields, such as social media platforms, medical imaging, and robotics. This abundance of content creation and sharing has introduced new challenges, particularly that of searching databases for similar content - Content Based Image Retrieval (CBIR) - a long-established research area in which improved efficiency and accuracy are needed for real-time retrieval. Artificial intelligence has made progress in CBIR and has significantly facilitated the process of instance search. In this survey we review recent instance retrieval works that are developed based on deep learning algorithms and techniques, with the survey organized by deep feature extraction, feature embedding and aggregation methods, and network fine-tuning strategies. Our survey considers a wide variety of recent methods, whereby we identify milestone work, reveal connections among various methods and present the commonly used benchmarks, evaluation results, common challenges, and propose promising future directions.

18.
J Pain Res ; 15: 3413-3422, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36320225

RESUMO

Purpose: The conventional lateral approach is widely used to treat radial head fractures with screws. However, the traditional incision may have shortcomings, including excessive exposure and significant scarring. We propose an innovative method - a mini-open lateral approach of less than 2.5 cm for surgical treatment of radial head fractures with screws. Methods: From Jan 2017 to Dec 2020, 34 patients diagnosed with closed radial head fracture were treated with open reduction and internal fixation (ORIF) in this study. The novel group (mini-open group) included 15 patients, and the other 19 patients were in the traditional group. The time of operation and the blood loss during operation were recorded. Postoperative clinical outcomes and radiographic results were recorded and compared between the two groups. The range of motion (ROM) in the elbow, the Visual Analogue Scale (VAS), the Mayo Elbow Performance Score (MEPS), Rating Scale of the American Shoulder and Elbow Surgeons (ASES), and the Shortened Disabilities of the Arm, Shoulder and Hand Questionnaire (Q-DASH) score and complications, such as wound infection, vascular and nerve damage, and fragment redisplacement were observed in the two groups. Results: In the comparison between the two groups, there was no significant difference in age, sex, cause of radial head fracture, or other basic information. The operation time, intraoperative blood loss, and VAS score at 3 days postoperation were significantly reduced in the novel group (p < 0.05). The follow-up results showed that there was no significant difference in MEPS, ASES, or Q-DASH scores between the two groups. Conclusion: The mini-open approach reduced intraoperative blood loss, shortened operation time, relieved patient pain, and achieved a satisfactory postoperative clinical result, which demonstrates that the novel approach is a safe and effective option for treating radial head fractures.

19.
Chem Sci ; 13(39): 11614-11622, 2022 Oct 12.
Artigo em Inglês | MEDLINE | ID: mdl-36320387

RESUMO

All-organic symmetric lithium-ion batteries (LIBs) show promising prospects in sustainable energy storage systems, due to their environmental friendliness, structural diversity and low cost. Nevertheless, it remains a great challenge to explore suitable electrode materials and achieve excellent battery performance for all-organic symmetric LIBs. Herein, a squaraine-anthraquinone polymer (PSQ) electrode material was designed through rational molecular engineering. The well-designed extended π-conjugated system, donor-acceptor structure, abundant redox-active sites and rational manipulation of weak inter-/intramolecular interactions endow the PSQ electrode with outstanding electrochemical performance. The capacity of the PSQ cathode can be optimized to 311.5 mA h g-1 by in situ carbon-template polymerization. Impressively, PSQ-based all-organic symmetric LIBs displayed high reversible capacity (170.8 mA h g-1 at 50 mA g-1), excellent rate performance (64.9% capacity retention at 4000 mA g-1 vs. 50 mA g-1), ultralong cycle life up to 30 000 cycles at 2000 mA g-1 and 97% capacity retention after 2500 cycles at 500 mA g-1, which is one of the best comprehensive battery performances among the all-organic LIBs reported thus far.

20.
ACS Nano ; 2022 Nov 04.
Artigo em Inglês | MEDLINE | ID: mdl-36331255

RESUMO

The high-efficiency transition metal-free electrocatalytic nitrate reduction reaction (NO3-RR) for ammonia synthesis has received more attention because of its green and environmentally friendly characteristics. Here, we report an efficient electrochemical NH3 synthesis directly from purely organic macrocyclic compounds α-, ß-, and γ-cyclodextrins (CDs)-catalyzed transition metal-free electroreduction of nitrate under ambient conditions. In comparison with α-, and ß-CDs, parent γ-CD presented uncommon catalytic performance with a relatively higher NH3 yield that can reach up to 2.28 mg h-1 cm-2 with a Faradaic efficiency (FE) of 63.2% at -0.9 V versus a reversible hydrogen electrode in alkaline medium, and the potassium ion-coordinated γ-CD complex can achieve a maximum NH3 production rate up to 4.66 mg h-1 cm-2 with an NH3 FE of 79.3%. Further comparison with permethyl-γ-CD, d-glucose, and poly(vinyl alcohol) for the NO3-RR indicated that the typical torus-shaped cyclic conformation and edge hydroxyl groups of parent CDs play important roles in the electrocatalytic process. The K+-mediated 3D γ-CD-K+ frameworks containing six CDs as nanoreactors greatly strengthen the enrichment effect of nitrate through hydrogen-bonding interaction and electrostatic interaction and promote the mass transfer, thus leading to the efficient NO3-RR in an alkaline electrolyte. This work provides a convenient, green, and economic method for high-performance NO3-RR, which has potential applications in the fields of environment, energy, and industry.

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