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1.
BMC Infect Dis ; 19(1): 408, 2019 May 10.
Artigo em Inglês | MEDLINE | ID: mdl-31077154

RESUMO

BACKGROUND: Diagnosis of tuberculosis (TB) in children is challenging. Epidemiological data of childhood pulmonary tuberculosis (PTB) are urgently needed. METHODS: We described trends in epidemiology, clinical characteristics, and treatment outcomes in seven cities of Shandong province, China, during 2005-2017. Data were collected from the China Information System for Disease Control and Prevention. RESULTS: Among 6283 (2.4% of all PTB) PTB cases aged < 18 years, 56.5% were male patients, 39.3% were smear-positive and 98.6% were new cases. The overall incidence of childhood PTB declined (7.62 to 3.74 per 100,000) during 2005-2017, with a non-significant change of annual percentage after 2010. While the incidence of smear-positive PTB (6.09 to 0.38 per 100,000 population) decreased significantly, but the incidence of smear-negative PTB (1.52 to 3.36 per 100,000 population) increased significantly during 2005-2017. The overall treatment success occurred among 94.2% childhood PTB. Ten children (0.2%) died. CONCLUSION: The overall incidence of childhood PTB declined significantly with the disease burden shifting from smear-positive PTB to smear-negative PTB. The discrepancies between notifications and estimations in both TB morbidity and mortality of children need to be addressed urgently.


Assuntos
Tuberculose Pulmonar/epidemiologia , Adolescente , Criança , Pré-Escolar , China/epidemiologia , Feminino , Humanos , Incidência , Lactente , Recém-Nascido , Masculino , Resultado do Tratamento , Tuberculose Pulmonar/diagnóstico , Tuberculose Pulmonar/tratamento farmacológico
2.
Medicine (Baltimore) ; 98(21): e15778, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-31124969

RESUMO

This study aimed to analyze the epidemiology of pulmonary tuberculosis (PTB) and gained insight into the future TB control plan in China.We extracted epidemiological, clinical, and geographic data from TB prevention and control institutions in 6 cities of Shandong province, China, during 2005 to 2017.Among 224,480 diagnosed PTB, rural residents accounted for 93%, smear-positive PTB 52%, and new cases 92%. The incidence rate of overall PTB declined from 40.8 to 26.25 per 100,000 during 2005 to 2017. Except smear-negative PTB (7.57-19.87 per 100,000), the incidence of smear-positive PTB and all that stratified by age, sex, and treatment history decreased. With 80% reduction, the incidence of smear-positive PTB (6.38 per 100,000) and relapse cases (1.01 per 100,000) were already very low in 2017.With persistent efforts to combat TB, the disease burden had shifted from smear-positive PTB to smear-negative PTB. While new cases need continuous attention, further reducing the incidence of smear-negative PTB and elderly patients may have a greater impact on future TB control.


Assuntos
Técnicas Bacteriológicas/estatística & dados numéricos , População Rural/estatística & dados numéricos , Tuberculose Pulmonar/epidemiologia , População Urbana/estatística & dados numéricos , Adolescente , Adulto , China/epidemiologia , Feminino , Humanos , Incidência , Masculino , Pessoa de Meia-Idade , Mycobacterium/crescimento & desenvolvimento , Estudos Retrospectivos , Escarro/microbiologia , Tuberculose Pulmonar/microbiologia , Adulto Jovem
3.
Acta Pharmacol Sin ; 2018 Jun 20.
Artigo em Inglês | MEDLINE | ID: mdl-29925918

RESUMO

Aspirin can efficiently inhibit liver cancer growth, but the mechanism is poorly understood. In this study, we report that aspirin modulates glucose uptake through downregulating glucose transporter 1 (GLUT1), leading to the inhibition of hepatoma cell proliferation. Our data showed that aspirin significantly decreased the levels of reactive oxygen species (ROS) and glucose consumption in hepatoma cells. Interestingly, we identified that GLUT1 and HIF1α could be decreased by aspirin. Mechanically, we demonstrated that the -1008/-780 region was the regulatory element of transcriptional factor NF-κB in GLUT1 promoter by luciferase report gene assays. PDTC, an inhibitor of NF-κB, could suppress the expression of GLUT1 in HepG2 and H7402 cells, followed by affecting the levels of ROS and glucose consumption. CoCl2-activated HIF1α expression could slightly rescue the GLUT1 expression inhibited by aspirin or PDTC, suggesting that aspirin depressed GLUT1 through targeting NF-κB or NF-κB/HIF1α signaling. Moreover, we found that GLUT1 was highly expressed in clinical HCC tissues relating to their paired adjacent normal tissues. Importantly, we observed that high level of GLUT1 was significantly correlated with the poor relapse-free survival of HCC patients by analysis of public data. Functionally, overexpression of GLUT1 blocked the PDTC-induced or aspirin-induced inhibition of glucose metabolism in HepG2 cells. Conversely, aspirin failed to work when GLUT1 was stably knocked down in the cells. Administration of aspirin could depress the growth of hepatoma cells through controlling GLUT1 in vitro and in vivo. Thus, our finding provides new insights into the mechanism by which aspirin depresses liver cancer.

4.
Acta Pharmacol Sin ; 2018 Jun 20.
Artigo em Inglês | MEDLINE | ID: mdl-29925919

RESUMO

We have reported that hepatitis B X-interacting protein (HBXIP, also termed LAMTOR5) can act as an oncogenic transcriptional co-activator to modulate gene expression, promoting breast cancer development. Pyruvate kinase muscle isozyme M2 (PKM2), encoded by PKM gene, has emerged as a key oncoprotein in breast cancer. Yet, the regulatory mechanism of PKM2 is still unexplored. Here, we report that HBXIP can upregulate PKM2 to accelerate proliferation of estrogen receptor positive (ER+) breast cancer. Immunohistochemistry analysis using breast cancer tissue microarray uncovered a positive association between the expression of HBXIP and PKM2. We also discovered that PKM2 expression was positively related with HBXIP expression in clinical breast cancer patients by real-time PCR assay. Interestingly, in ER+ breast cancer cells, HBXIP was capable of upregulating PKM2 expression at mRNA and protein levels in a dose-dependent manner, as well as increasing the activity of PKM promoter. Mechanistically, HBXIP could stimulate PKM promoter through binding to the -779/-579 promoter region involving co-activation of E2F transcription factor 1 (E2F1). In function, cell viability, EdU, colony formation, and xenograft tumor growth assays showed that HBXIP contributed to accelerating cell proliferation through PKM2 in ER+ breast cancer. Collectively, we conclude that HBXIP induces PKM2 through transcription factor E2F1 to facilitate ER+ breast cancer cell proliferation. We provide new evidence for the mechanism of transcription regulation of PKM2 in promotion of breast cancer progression.

5.
Chin Med J (Engl) ; 131(6): 696-703, 2018 Mar 20.
Artigo em Inglês | MEDLINE | ID: mdl-29521293

RESUMO

Background: Paclitaxel (PTX) could inhibit the growth of fibroblasts, which occurs in proliferative cholangitis and leads to biliary stricture. However, its use has been limited due to poor bioavailability and local administration for short time. This study designed and synthesized a new PTX-conjugated chitosan film (N-succinyl-hydroxyethyl chitosan containing PTX [PTX-SHEC]) and evaluated its safety and efficiency using in vivo and in vitro experiments. Methods:: The SHEC conjugated with PTX was confirmed by nuclear magnetic resonance (NMR) and Fourier-transform infrared spectroscopy (FT-IR) measurements. Drug releases in vitro and in vivo were determined using high-performance liquid chromatography. Cell viability in vitro was measured using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide. Rabbit biliary stricture model was constructed. All rabbits randomly divided into five groups (n = 8 in each group): the sham-operated rabbits were used as control (Group A), Groups B received laparotomies and suture, Group C received laparotomies and covered SHEC suture without the PTX coating, Group D received laparotomies and covered PTX-SHEC suture, and Group E received laparotomies and 1000 µmol/L PTX administration. Liver function tests and residual dosage of PTX from each group were measured by enzyme-linked immunosorbent assay. Histological data and α-smooth muscle actin (SMA) immunohistochemical staining of common bile duct were examined. Results:: NMR and FT-IR indicated that PTX was successfully introduced, based on the appearance of signals at 7.41-7.99 ppm, 1.50 ppm, and 1.03 ppm, due to the presence of aromatic protons, methylene protons, and methyl protons of PTX, respectively. No bile leak was observed. The PTX-conjugated film could slowly release PTX for 4 weeks (8.89 ± 0.03 µg at day 30). The in vitro cell viability test revealed significantly different levels of toxicity between films with and without PTX (111.7 ± 4.0% vs. 68.1 ± 6.0%, P < 0.001), whereas no statistically significant difference was observed among the three sets of PTX-contained films (67.7 ± 5.4%, 67.2 ± 3.4%, and 59.1 ± 6.0%, P > 0.05). Histological examinations revealed that after 28 days of implantment, Groups D and E (but not Group C) had less granulation tissue and glandular hyperplasia in the site of biliary duct injury than Group B. The pattern was more obvious in Group D than Group E. Less α-SMA-positive cells were found in tissue from Groups D and E. Comparing with Group E, the liver function was improved significantly in Group D, including total bilirubin (2.69 ± 1.03 µmol/L vs. 0.81 ± 0.54 µmol/L, P = 0.014), alanine aminotransferase (87.13 ± 17.51 U/L vs. 42.12 ± 15.76 U/L, P = 0.012), and alkaline phosphatase (60.61 ± 12.31 U/L vs. 40.59 ± 8.78 U/L, P < 0.001). Conclusions: PTX-SHEC film effectively inhibites the myofibroblast proliferation and extracellular matrix over-deposition during the healing process of biliary reconstruction. This original film might offer a new way for reducing the occurrence of the benign biliary stricture.


Assuntos
Quitosana/química , Colangite/tratamento farmacológico , Membranas Artificiais , Paclitaxel/farmacologia , Paclitaxel/uso terapêutico , Animais , Linhagem Celular Tumoral , Proliferação de Células/efeitos dos fármacos , Portadores de Fármacos/química , Humanos , Espectroscopia de Ressonância Magnética , Paclitaxel/química , Coelhos , Espectroscopia de Infravermelho com Transformada de Fourier
6.
ACS Appl Mater Interfaces ; 9(44): 38950-38958, 2017 Nov 08.
Artigo em Inglês | MEDLINE | ID: mdl-29039907

RESUMO

Lithium-sulfur (Li-S) battery is an important candidate for next-generation energy storage. However, the reaction between polysulfide and lithium (Li) anode brings poor cycling stability, low Coulombic efficiency, and Li corrosion. Herein, we report a Li protection technology. Li metal was treated in crown ether containing electrolyte, and thus, treated Li was further used as the anode in Li-S cell. Due to the coordination between Li+ and crown ether, a Li+-permeable film can be formed on Li, and the film is proved to be able to block the detrimental reaction between Li anode and polysulfide. By using the Li anode pretreated in 2 wt % B15C5-containing electrolyte, Li-S cell exhibits significantly improved cycling stability, such as∼900 mAh g-1 after 100 cycles, and high Coulombic efficiency of>93%. In addition, such effect is also notable when high S loading condition is applied.

7.
Huan Jing Ke Xue ; 37(1): 288-92, 2016 Jan 15.
Artigo em Chinês | MEDLINE | ID: mdl-27078969

RESUMO

With acceleration of urbanization, water shortages will become a serious problem. Usage of reclaimed water for flushing and watering of the green areas will be common in the future. To study the heavy metal contamination of soils after green area irrigation using recycled wastewater from special industries, we selected sewage and laboratory wastewater as water source for integrated oxidation ditch treatment, and the effluent was used as irrigation water of the green area. The irrigation units included broad-leaved forest, bush and lawn. Six samples sites were selected, and 0-20 cm soil of them were collected. Analysis of the heavy metals including Cr, Mn, Ni, Cu, Zn, As, Cd and Pb in the soil showed no significant differences with heavy metals concentration in soil irrigated with tap water. The heavy metals in the soil irrigated with recycled water were mainly enriched in the surface layer, among which the contents of Cr, Ni, Cu, Zn and Pb were below the soil background values of Beijing. A slight pollution of As and Cd was found in the soil irrigated by recycled water, which needs to be noticed.


Assuntos
Irrigação Agrícola , Metais Pesados/análise , Reciclagem , Poluentes do Solo/análise , Água/química , Pequim , Monitoramento Ambiental , Poluição Ambiental , Esgotos , Solo/química
9.
PLoS One ; 10(5): e0128298, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26020921

RESUMO

BACKGROUND: Multidrug-resistant tuberculosis (MDR-TB) resulting from various factors has raised serious public health concerns worldwide. Identifying the ecological risk factors associated with MDR-TB is critical to its prevention and control. This study aimed to explore the association between the development of MDR-TB and the risk factors at the group-level (ecological risk factors) in China. METHODS: Data on MDR-TB in 120 counties were obtained from the National Tuberculosis Information Management System, and data on risk-factor variables were extracted from the Health Statistical Yearbook, provincial databases, and the meteorological bureau of each province (municipality). Partial Least Square Path Modeling was used to detect the associations. RESULTS: The median proportion of MDR-TB in new TB cases was 3.96% (range, 0-39.39%). Six latent factors were extracted from the ecological risk factors, which explained 27.60% of the total variance overall in the prevalence of MDR-TB. Based on the results of PLS-PM, TB prevention, health resources, health services, TB treatment, TB detection, geography and climate factors were all associated with the risk of MDR-TB, but socioeconomic factors were not significant. CONCLUSIONS: The development of MDR-TB was influenced by TB prevention, health resources, health services, TB treatment, TB detection, geography and climate factors. Such information may help us to establish appropriate public health intervention strategies to prevent and control MDR-TB and yield benefits to the entire public health system in China.


Assuntos
Tuberculose Resistente a Múltiplos Medicamentos/epidemiologia , Tuberculose Pulmonar/epidemiologia , China/epidemiologia , Clima , Bases de Dados Factuais , Geografia , Humanos , Análise dos Mínimos Quadrados , Prevalência , Fatores de Risco
10.
Sichuan Da Xue Xue Bao Yi Xue Ban ; 46(6): 811-5, 2015 Nov.
Artigo em Chinês | MEDLINE | ID: mdl-26867312

RESUMO

OBJECTIVE: To establish gene assays for determining (anti) estrogen effect of environmental chemicals; and to compare the reactivity and sensitivity of two assays with different estrogen subtype. METHODS: Human estrogen receptor a (hERalpha) and hERbeta mediated reporter gene assays employing firefly luciferase (Luc) were developed. The expression plasmid hERalpha or hERbeta was constructed and transiently co-transfected into LLC-MK2 cells with pERE-minP-Luc2P reporter plasmid and the control plasmid pGL4.74. Estradiol (E2) and diethylstilbestrol (DES) served as positive test substances to verify the performance of the assays. The effectiveness of the assays for detecting anti-estrogenic activity was tested using 10(-5) mol/L ICI 182, 780 under different concentrations of E2. The performance of the two subtype-mediated assays was verified and compared using bisphenol A (BPA) and genistein (GS). RESULTS: The hERalpha mediated assay found expression of reported gene at 1.9 x 10(-11) mol/L E2; and the largest luciferase activity was shown at 10(-8) mol/L E2, resulting in 30.7-fold of vehicle control. The hERbeta mediated assay found expression of reporter gene at 2.2 x 10(11) mol/L E2, and the largest luciferase activity was shown at 10(-8) mol/L E2, resulting in 14.4-fold of vehicle control. ICI 182, 780 inhibited estrogenic activity of E2 significantly. In both assays, E2 failed to induce luciferase activity without hER-pcDNA3.1. BPA and GS induced luciferase activity. CONCLUSION: Both assays have high sensitivity and reproducibility for detecting (anti) estrogen effect. The pGL4-based hERbeta has lower sensitivity than the hERalpha- mediated reporter gene assay. BPA shows stronger estrogenic activity than GS in hERalpha mediated reporter gene assay; whereas, GS shows stronger estrogenic activity than BPA in hERbeta mediated reporter gene assay.


Assuntos
Antagonistas de Estrogênios/análise , Genes Reporter , Receptores Estrogênicos/genética , Compostos Benzidrílicos/química , Linhagem Celular , Dietilestilbestrol/antagonistas & inibidores , Estradiol/química , Genisteína/química , Humanos , Luciferases de Vaga-Lume , Fenóis/química , Plasmídeos , Reprodutibilidade dos Testes , Transfecção
12.
Glob Health Action ; 7: 23620, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-24929074

RESUMO

BACKGROUND: The current prevalence of tuberculosis (TB) in the People's Republic of China (P. R. China) demonstrates geographical heterogeneities, which show that the TB prevalence in the remote areas of Western China is more serious than that in the coastal plain of Eastern China. Although a lot of ecological studies have been applied in the exploration on the regional difference of disease risks, there is still a paucity of ecological studies on TB prevalence in P. R. China. OBJECTIVE: To understand the underlying factors contributing to the regional inequity of TB burden in P. R. China by using an ecological approach and, thus, aiming to provide a basis to eliminate the TB spatial heterogeneity in the near future. DESIGN: Latent ecological variables were identified by using exploratory factor analysis from data obtained from four sources, i.e. the databases of the National TB Control Programme (2001-2010) in P. R. China, the China Health Statistical Yearbook during 2002-2011, the China Statistical Yearbook during 2002-2011, and the provincial government websites in 2013. Partial least squares path modelling was chosen to construct the structural equation model to evaluate the relationship between TB prevalence and ecological variables. Furthermore, a geographically weighted regression model was used to explore the local spatial heterogeneity in the relationships. RESULTS: The latent ecological variables in terms of 'TB prevalence', 'TB investment', 'TB service', 'health investment', 'health level', 'economic level', 'air quality', 'climatic factor' and 'geographic factor' were identified. With the exception of TB service and health levels, other ecological factors had explicit and significant impacts on TB prevalence to varying degrees. Additionally, each ecological factor had different impacts on TB prevalence in different regions significantly. CONCLUSION: Ecological factors that were found predictive of TB prevalence in P. R. China are essential to take into account in the formulation of locally comprehensive strategies and interventions aiming to tailor the TB control and prevention programme into local settings in each ecozone.


Assuntos
Ecologia , Tuberculose Pulmonar/epidemiologia , China/epidemiologia , Ecologia/estatística & dados numéricos , Geografia Médica , Humanos , Modelos Biológicos , Prevalência , Fatores de Risco
13.
Environ Sci Pollut Res Int ; 21(5): 3955-62, 2014 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-24297465

RESUMO

There is a lack of information on the interactive relationship of absorption and transformation between two inorganic arsenic (As) species and two inorganic selenium (Se) species in rice grown under hydroponic condition. Interactive effects of inorganic As (As(III)) and (As(V)) and Se (Se(IV)and Se(VI)) species on their uptake, accumulation, and translocation in rice (Oryza sativa L.) seedlings were investigated in hydroponic culture. The results clearly showed the interactive effects of inorganic As and Se on their uptake by rice. The presence of Se reduced the sum of As species in the rice shoots regardless of Se speciation. If Se is present as Se(IV), then is it is accompanied by a corresponding increase of the sum of As species, but if Se is present as Se(VI), then there is no change in the sum of As species in rice roots. These effects are observed regardless of initial As speciation. When the rice plants are exposed to Se(IV), the presence of As increases the sum of Se species in the roots, and decreases the sum of Se species in the corresponding shoots. This effect is more pronounced for As(III) than for As(V). There is no effect on Se during exposure to Se(VI). Co-existence of As also increased SeMet in rice roots.


Assuntos
Arsênico/farmacologia , Poluentes Ambientais/farmacologia , Oryza/metabolismo , Selênio/farmacologia , Interações de Medicamentos , Hidroponia , Raízes de Plantas/metabolismo , Brotos de Planta/metabolismo , Plântula/metabolismo
14.
Huan Jing Ke Xue ; 34(10): 4119-25, 2013 Oct.
Artigo em Chinês | MEDLINE | ID: mdl-24364339

RESUMO

A pot experiment was conducted to clarify the effect of selenium on the uptake and translocation of manganese (Mn), iron (Fe) , phosphorus (P) and selenium (Se) in rice ( Oryza sativa L.). The results showed that addition of Se led to the significant increase of Se concentration in iron plaque on the root surface, root, shoot, husk and brown rice, and significant decrease of Mn concentration in shoot, husk and brown rice. At the Se concentrations of 0.5 and 1.0 mg.kg-1 in soil, Mn concentrations in rice shoot decreased by 32. 2% and 35.0% respectively, in husk 22.0% and 42.6% , in brown rice 27.5% and 28.5% , compared with the Se-free treatment. There was no significant effect of Se on the P and Fe concentrations in every parts of rice, except for Fe concentrations in husk. The translocation of P and Fe from iron plaque, root, shoot and husk to brown rice was not significantly affected by Se addition, but Mn translocation from iron plaque and root to brown rice was significantly inhibited by Se addition. Addition of 1.0 mg.kg-1. Se resulted in the decrease of translocation factor from iron plaque and root to brown rice by 38.9% and 37.9%, respectively, compared with the control treatment. The distribution ratios of Mn, Fe, P and Se in iron plaque, root, shoot, husk and brown rice were also affected by Se addition. The results indicated that Mn uptake, accumulation and translocation in rice could be decreased by the addition of Se in soil, therefore, Se addition could reduce the Mn harm to human health through food chain.


Assuntos
Ferro/metabolismo , Manganês/metabolismo , Oryza/metabolismo , Fósforo/metabolismo , Selênio/farmacologia , Oryza/efeitos dos fármacos , Raízes de Plantas/metabolismo , Solo/química , Poluentes do Solo/metabolismo
15.
Huan Jing Ke Xue ; 34(4): 1357-62, 2013 Apr.
Artigo em Chinês | MEDLINE | ID: mdl-23798114

RESUMO

Three waste water treatment plants (WWTPs) in Beijing were selected as cases to study the occurrence and fate of phthalates. Contents of di-methyl phthalate (DMP), di-ethyl phthalate (DEP), di-butyl phthalate (DBP), butyl-benzyl phthalate (BBP), di-octyl phthalate (DOP) and di-(2-ehtylhexyl) phthalate (DEHP) in influent, effluent of secondary setting tank and excess sludge in those WWTPs were determined. The mean concentration of DMP, DEP, DBP and DEHP are 0.98, 0.21 x 10(2), 0.27 x 10(2) and 0.15 x 10(2) microg x L(-1) respectively. BBP and DOP were not found in those WWTPs. Only DBP and DEHP were detected in dewatered sludge with mean concentration of 0.37 microg x kg(-1) and 0.31 x 10(3) microg x kg(-1) DW. The removal efficiency of DMP, DEP, DBP and DEHP varied from 68.3% -82.6%, 94.5% - 98.2%, 74.7% -95.0% and 90.5% -90.7% respectively. The main removal mechanism should be biodegradation and volatilization to the air. Higher concentration of DBP and DEHP in effluent and dewatered sludge should be concerned.


Assuntos
Ácidos Ftálicos/química , Esgotos/química , Instalações de Eliminação de Resíduos , Eliminação de Resíduos Líquidos/métodos , Águas Residuárias/química , China , Cidades , Dibutilftalato/análise , Monitoramento Ambiental , Ácidos Ftálicos/análise
16.
Patholog Res Int ; 2012: 908206, 2012.
Artigo em Inglês | MEDLINE | ID: mdl-22482084

RESUMO

The aim of this study was to evaluate CD44v6 protein expression and its prognostic value of CD44v6 in ovarian carcinoma. The expression of CD44v6 was analyzed in 62 patients with ovarian carcinoma by immunohistochemical method. The data obtained were analyzed by univariate and multivariate analyses. The present study clearly demonstrates that tumor tissues from 41 (66.1%) patients showed positive expression with CD44v6. The expression of CD44v6 was significantly correlated with histological type, FIGO stage and histological grade of ovarian carcinomas. Concerning the prognosis, the survival period of patients with CD44v6 positive was shorter than that of patients with CD44v6 negative (36.6% versus 66.7%, 5-year survival, P < 0.05). Univariate analysis showed that CD44v6 expression, histological type, FIGO stage and histological grade were associated with 5-year survival, and CD44v6 expression was associated with histological type, FIGO stage and histological grade and 5-year survival. In multivariate analysis, using the COX-regression model, CD44v6 expression was important prognostic factor. In conclusion, these results suggest that CD44v6 may be related to histological type, FIGO stage and histological grade of ovarian carcinomas, and CD44v6 may be an important molecular marker for poor prognosis in ovarian carcinomas.

17.
Zhongguo Zhen Jiu ; 32(1): 26-30, 2012 Jan.
Artigo em Chinês | MEDLINE | ID: mdl-22295817

RESUMO

OBJECTIVE: To probe an effective therapeutic method for the treatment of shoulder periarthritis. METHODS: Ninety-six patients were randomly divided into an acupuncture group and an abdominal acupuncture group, 48 cases in each. According to clinical pathological staging, the disease was divided into pain stage and adhesion stage. In abdominal acupuncture group, 24 cases were in pain stage and treated with acupuncture at Zhongwan (CV 12), Shangqu (KI 17) on the healthy side, Huaroumen (ST 24) on the affected side and others; 24 cases were in adhesion stage and treated with acupuncture at Zhongwan (CV 12), Xiawan (CV 10), Qihai (CV 6), Guanyuan (CV 4) and others. In acupuncture group, there were 24 cases in either pain stage or adhesion stage, treated with acupuncture at Jianyu (LI 15), Jianliao (TE 14), Jianzhen (SI 9) and others on the affected side. In either group, the treatment was given three times a week, three weeks treatment made one session, 9 treatments totally. Before and after treatment, the Visual Analogue Scale (VAS) was adopted for pain assessment and functional activity score (Melle score) was for shoulder joint function assessment for all the patients. RESULTS: After one session treatment, the efficacy was compared between two groups. In abdominal acupuncture group, the total effective rates were 95.8% (23/24) and 91.7% (22/24) in pain stage and adhesion stage respectively. In acupuncture group, the total effective rates were 91.7% (22/24) and 79.2% (19/24) in pain stage and adhesion stage respectively. The efficacy in adhesion stage of abdominal acupuncture group was better than that in acupuncture group (P < 0.05). After treatment, VAS score and Melle score were all reduced as compared with those before treatment in either group (all P < 0.01), in which, the reducing ranges in abdominal acupuncture group were larger than those in acupuncture group (all P < 0.05). CONCLUSION: Abdominal acupuncture achieves a significant efficacy on shoulder periarthritis in stages. It is an effective therapy for shoulder periarthritis.


Assuntos
Terapia por Acupuntura , Periartrite/terapia , Dor de Ombro/terapia , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Resultado do Tratamento
18.
Ying Yong Sheng Tai Xue Bao ; 21(7): 1883-91, 2010 Jul.
Artigo em Chinês | MEDLINE | ID: mdl-20879551

RESUMO

Arsenic (As) is a ubiquitous chemical element in environment, and the increasingly serious As pollution is highly concerned all over the world. China has been considered as one of the countries and regions with serious As pollution in the world by the World Health Organization (WHO). Recent studies indicated that food is one of the major contributors of As in human diets. Edible plants are essential in the diet structure in human life, which often contain high level of As. However, the total As in food can not exactly reflect the toxicity of As, while As speciation closely relates to the As bio-toxicity. Inorganic arsenic is verified as the carcinogen based on human epidemiological data. This paper reviewed the As species in edible plants, their bio-toxicity, and analytical methods.


Assuntos
Arseniatos/análise , Arsênico/química , Arsenitos/análise , Contaminação de Alimentos/análise , Plantas Comestíveis/química , Arsênico/análise , Arsenicais/análise
19.
Bull Environ Contam Toxicol ; 85(2): 190-4, 2010 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-20652221

RESUMO

The present study characterized the distribution, sources as well as carcinogenic potency of PAHs in surface soil from metropolitan region of northern China. The total PAHs in topsoil ranged from 322.6 to 23244.7 microg kg(-1). The mean and median concentrations of 16 PAHs were 1040.8 and 626.7 microg kg(-1), respectively. Source analysis revealed that pyrogenic sources played a major role at the locations and pyrogenic PAHs were mainly from incomplete combustion of coal, biomass and petroleum. The calculated mean BaP-equivalent values for individual carcinogenic PAHs were 148.4 microg kg(-1).


Assuntos
Carcinógenos/análise , Hidrocarbonetos Policíclicos Aromáticos/análise , Poluentes do Solo/análise , China , Cidades , Monitoramento Ambiental , Medição de Risco
20.
Huan Jing Ke Xue ; 31(12): 3036-42, 2010 Dec.
Artigo em Chinês | MEDLINE | ID: mdl-21360896

RESUMO

Characteristics and concentrations of As in Chinese Herbal Medicines (CHMs) from Hebei province (including samples collected from fields and from medicine markets) were investigated, and the ADI (allowable daily intake) standard value from FAO/WHO was used for preliminary assessment of As risk on human health. The results showed that the average of As concentrations in different roots which were used as medicines, ranged from 0.14 mg/kg to 0.54 mg/kg,while for shoots which were used as medicines, average value of As concentrations in Dendranthema morifolium was 1.42 mg/kg, and the range in other species was from 0.09 mg/kg to 0.27 mg/kg. Based on Green Standards of Medicinal Plants and Preparations for Foreign Trade and Economy (2.0 mg/kg), the percentage of samples with As concentrations exceeding standard was 3.27% (n = 153) in roots and 9.09% (n = 44) in shoots,and 4.57% (n = 197) in total CHMs samples. As concentrations in CHMs from fields ranged from 0.03 mg/kg to 0.73 mg/kg,which were all lower than 2.0 mg/kg. However, As concentrations in CHMs from markets ranged from 0.05 mg/kg to 7.05 mg/kg, and the concentrations of As in 6.36% of samples exceeded the limited standard. Arsenic concentrations in samples from markets were significantly higher than those from fields (p < 0.05). As concentrations in Compositae were distributed widely from 0.08 mg/kg to 7.05 mg/kg,and the average at 0.87 mg/kg,while the average of As concentrations in other six families were between 0.21 mg/kg and 0.41 mg/kg, and As levels in 75% of samples for each family were below 0.5 mg/kg. Compared to Compositae samples, the CHMs from other families have higher security. ADI regulated by FAO/WHO was used to assess As risk in CHMs on human health in this study as well. As daily intake through CHMs from markets varied from 0.90 microg/d to 19.7 microg/d, and percentages of the daily intake of As in CHMs to ADI were in the range of 0.70% to 15.4%, which indicated that As in CHMs from markets had a potential risk on human health after intake.


Assuntos
Arsênico/análise , Contaminação de Medicamentos , Medicamentos de Ervas Chinesas/química , China , Medicamentos de Ervas Chinesas/análise , Humanos , Medição de Risco
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