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1.
Sci Total Environ ; 807(Pt 2): 150886, 2021 Oct 09.
Artigo em Inglês | MEDLINE | ID: mdl-34634341

RESUMO

Atmospheric aerosols play an important role in affecting clouds and precipitation by serving as condensation/ice nuclei. However, how to quantify the contribution of anthropogenic aerosols to the alteration of clouds and precipitation remains unknown. In this study, using a Weather Research and Forecasting-Chemistry (WRF-Chem) model, we quantified the impacts of anthropogenic aerosols on cloud water properties under different precipitation grades during a single rainfall event over eastern China. The results of this study show that anthropogenic aerosols have varying effects on hourly precipitation with heavy (greater than 1.04 mm/h), moderate (0.41-1.04 mm/h), and light (less than 0.41 mm/h) grades. Due to the presence of anthropogenic aerosols, heavy precipitation is intensified by 70.96%; however, moderate and light precipitation is further weakened by 24.87% and 86.43%, respectively. For heavy precipitation, the addition of anthropogenic aerosols induces an enhancement in upward motion, increases the cloud water path and effective radius through the aerosol-radiation interaction (ARI) effect, which is the main reason for the intensification of heavy-grade precipitation. In addition, the weakened upward motion and decreased ice water path caused by ARI and aerosol-cloud interaction (ACI) effects play common roles in reducing moderate and light precipitation. Studying anthropogenic aerosols' impacts on precipitation is of great importance for understanding the influence of anthropogenic pollution on the weather and climate and even for promoting precipitation forecasting and prediction.

2.
Biomed Pharmacother ; 144: 112298, 2021 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-34649219

RESUMO

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, and it is a liver manifestation of metabolic syndrome, with a histological spectrum from simple steatosis to non-alcoholic steatohepatitis (NASH). NASH can evolve into progressive liver fibrosis and eventually lead to liver cirrhosis. The pathological mechanism of NASH is multifactorial, involving a series of metabolic disorders and changes that trigger low-level inflammation in the liver and other organs. In the pathogenesis of NASH, the signal transduction pathway involving succinate and the succinate receptor (G-protein-coupled receptor 91, GPR91) regulates inflammatory cell activation and liver fibrosis. This review describes the mechanism of the succinate-GPR91 signalling pathway in NASH and summarizes the drugs that act on this pathway, with the aim of providing a new approach to NASH treatment.

3.
Analyst ; 146(20): 6202-6210, 2021 Oct 11.
Artigo em Inglês | MEDLINE | ID: mdl-34519726

RESUMO

Chloride ion (Cl-), the most common anion in animal brain, has been verified to play a vital role in maintaining normal physiological processes. Thus, development of a reliable platform to determine Cl- is of great significance for brain research involving Cl-. In this work, a ratiometric electrochemical microsensor (REM) for the in vivo measurement of cerebral Cl- was designed. To prepare REM, uniform Ag nanoparticles (Ag NPs) with nano-level sizes were synthesized via an adsorption-reduction process, which served as selective recognition elements for Cl- determination, while methylene blue (MB) was absorbed and acted as an inner reference unit to avoid the environmental interference of complicated brain systems. As a result, this developed REM exhibited high sensitivity and selectivity, as well as good stability, reproducibility and anti-biofouling. This reliable approach was established to monitor Cl- in mouse brain.


Assuntos
Técnicas Biossensoriais , Nanopartículas Metálicas , Animais , Cloretos , Técnicas Eletroquímicas , Camundongos , Reprodutibilidade dos Testes , Prata
4.
J Med Chem ; 64(15): 10557-10580, 2021 08 12.
Artigo em Inglês | MEDLINE | ID: mdl-34260235

RESUMO

The widespread use of antibiotics has made the problem of bacterial resistance increasingly serious, and the study of new drug-resistant bacteria has become the main direction of antibacterial drug research. Among antibiotics, the fully synthetic oxazolidinone antibacterial drugs linezolid and tedizolid have been successfully marketed and have achieved good clinical treatment effects. Oxazolidinone antibacterial drugs have good pharmacokinetic and pharmacodynamic characteristics and unique antibacterial mechanisms, and resistant bacteria are sensitive to them. This Perspective focuses on reviewing oxazolidinones based on the structural modification of linezolid and new potential oxazolidinone drugs in the past 10 years, mainly describing their structure, antibacterial activity, safety, druggability, and so on, and discusses their structure-activity relationships, providing insight into the reasonable design of safer and more potent oxazolidinone antibacterial drugs.


Assuntos
Antibacterianos/farmacologia , Bactérias/efeitos dos fármacos , Oxazolidinonas/farmacologia , Antibacterianos/síntese química , Antibacterianos/química , Humanos , Testes de Sensibilidade Microbiana , Estrutura Molecular , Oxazolidinonas/síntese química , Oxazolidinonas/química
5.
Eur J Med Chem ; 220: 113451, 2021 Aug 05.
Artigo em Inglês | MEDLINE | ID: mdl-33895500

RESUMO

All-trans-retinoic acid (ATRA) is effective for preventing cancer and treating skin diseases and acute promyelocytic leukaemia (APL). These pharmacological effects of ATRA are mainly mediated by retinoid X receptors (RXRs) and retinoic acid receptors (RARs). This article provides a comprehensive overview of the clinical progress on and the molecular mechanisms of ATRA in the treatment of APL. ATRA can promote the transcriptional activation of differentiation-related genes and regulate autophagy by inhibiting mTOR, which results in anti-APL effects. In detail, the structures, pharmacological effects, and clinical studies of 68 types of ATRA analogues are described. These compounds have excellent antitumour therapeutic potential and could be used as lead compounds for further development and research.


Assuntos
Antineoplásicos/farmacologia , Leucemia Promielocítica Aguda/tratamento farmacológico , Serina-Treonina Quinases TOR/antagonistas & inibidores , Tretinoína/farmacologia , Antineoplásicos/química , Proliferação de Células/efeitos dos fármacos , Humanos , Leucemia Promielocítica Aguda/metabolismo , Leucemia Promielocítica Aguda/patologia , Serina-Treonina Quinases TOR/metabolismo , Tretinoína/análogos & derivados , Tretinoína/química
6.
Biomed Pharmacother ; 137: 111313, 2021 May.
Artigo em Inglês | MEDLINE | ID: mdl-33556871

RESUMO

The SARS-CoV-2 outbreak and pandemic that began near the end of 2019 has posed a challenge to global health. At present, many candidate small-molecule therapeutics have been developed that can inhibit both the infection and replication of SARS-CoV-2 and even potentially relieve cytokine storms and other related complications. Meanwhile, host-targeted drugs that inhibit cellular transmembrane serine protease (TMPRSS2) can prevent SARS-CoV-2 from entering cells, and its combination with chloroquine and dihydroorotate dehydrogenase (DHODH) inhibitors can limit the spread of SARS-CoV-2 and reduce the morbidity and mortality of patients with COVID-19. The present article provides an overview of these small-molecule therapeutics based on insights from medicinal chemistry research and focuses on RNA-dependent RNA polymerase (RdRp) inhibitors, such as the nucleoside analogues remdesivir, favipiravir and ribavirin. This review also covers inhibitors of 3C-like protease (3CLpro), papain-like protease (PLpro) and other potentially innovative active ingredient molecules, describing their potential targets, activities, clinical status and side effects.


Assuntos
Antivirais , COVID-19 , Terapia de Alvo Molecular/métodos , SARS-CoV-2 , Antivirais/classificação , Antivirais/farmacologia , COVID-19/tratamento farmacológico , COVID-19/metabolismo , Inibidores Enzimáticos/farmacologia , Humanos , SARS-CoV-2/efeitos dos fármacos , SARS-CoV-2/enzimologia , Terapias em Estudo
7.
Environ Pollut ; 274: 116527, 2021 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-33508715

RESUMO

Polycyclic aromatic hydrocarbons (PAHs) and nitro-PAHs (NPAHs) in PM2.5 were first observed at a background site (Yuzhong site: YZ site) in the northwestern highlands of China in five seasonal campaigns. Compared with major northwestern cities, PAHs and NPAHs at the YZ site were at a lower level but showed consistent seasonal differences. The PAH and NPAH concentrations peaked in the winter campaigns, which were 36.11 ± 6.54 ng/m3 and 418.11 ± 123.55 pg/m3, respectively, in winter campaign 1 and 28.97 ± 10.07 ng/m3 and 226.89 ± 133.54 pg/m3, respectively, in winter campaign 2. These values were approximately a dozen times larger those in other campaigns. The diagnostic ratios indicate that vehicle emissions were the primary source of the PAHs throughout the five campaigns, and coal and biomass combustion also contributed during the winter, summer, and fall campaigns. Among NPAHs, 2-nitrofluoranthene and 2-nitropyrene were generated through OH radical-initiated reactions during atmospheric transport, while 1-nitropyrene came from combustion sources. There is an observation worth pondering, which is that the ratio between pyrene and fluoranthene increased abnormally in the spring and fall campaigns, which is presumably caused by the burning of Tibetan barley straw in the northwestern highlands. The backward trajectories over Tibetan areas in Qinghai and southwestern Gansu are consistent with this hypothesis. In addition, this study reported for the first time that the burning of Tibetan barley straw has become a seasonal contributor to air pollution in northwestern China and is participating in the atmospheric transport of air pollutants driven by the monsoon in East Asia, which urgently requires further research.


Assuntos
Poluentes Atmosféricos , Hidrocarbonetos Policíclicos Aromáticos , Poluentes Atmosféricos/análise , China , Cidades , Monitoramento Ambiental , Extremo Oriente , Material Particulado/análise , Hidrocarbonetos Policíclicos Aromáticos/análise , Estações do Ano
8.
Neurochem Res ; 46(3): 638-647, 2021 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-33394221

RESUMO

Alzheimer's disease (AD) is a common neurodegenerative disease associated with deposition of ß-amyloid peptide (Aß). Platycodin D (PLD), a triterpenesaponin, may possess neuro-protective effect. In the current study, we aimed to explore the effects of PLD on Aß-induced inflammation and oxidative stress in microglial BV-2 cells. Our study showed that PLD treatment improved cell viability in Aß-induced BV-2 cells. PLD attenuated Aß-induced inflammation with deceased production of TNF-α, IL-1ß and IL-6 in Aß-induced BV-2 cells. PLD also mitigated the oxidative stress in Aß-induced BV-2 cells, as evidenced by deceased production of ROS and MDA, and increased SOD activity. Furthermore, the increased expression levels of TLR4 and p-p65 and decreased IκBα expression in the Aß-stimulated BV-2 cells were attenuated by PLD treatment. Overexpression of TLR4 reversed the anti-inflammatory effect of PLD in Aß-stimulated BV-2 cells. In addition, PLD treatment enhanced the Aß-stimulated increase in the expression levels of Nrf2, HO-1, and NQO1 in BV-2 cells. Knockdown of Nrf2 abrogated the anti-oxidative effect of PLD in Aß-stimulated BV-2 cells. In conclusion, these findings indicated that PLD protected BV-2 cells from Aß-induced oxidative stress and inflammation via regulating the TLR4/NF-κB and Nrf2/HO-1 signaling pathways. Thus, PLD may be a potential candidate for the treatment of AD.


Assuntos
Inflamação/tratamento farmacológico , Estresse Oxidativo/efeitos dos fármacos , Saponinas/farmacologia , Transdução de Sinais/efeitos dos fármacos , Triterpenos/farmacologia , Peptídeos beta-Amiloides , Animais , Linhagem Celular , Sobrevivência Celular/efeitos dos fármacos , Técnicas de Silenciamento de Genes , Heme Oxigenase-1/metabolismo , Inflamação/induzido quimicamente , Proteínas de Membrana/metabolismo , Camundongos , Fator 2 Relacionado a NF-E2/genética , Fator 2 Relacionado a NF-E2/metabolismo , Subunidade p50 de NF-kappa B/metabolismo , Fragmentos de Peptídeos , Receptor 4 Toll-Like/metabolismo
10.
Water Sci Technol ; 82(9): 1961-1970, 2020 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-33201858

RESUMO

Among the different antibiotics, tetracycline hydrochloride (TCH) is one of the most commonly used. In this study, the activated sodium persulfate (SPS) process induced by microwave (MW) energy was used to treat TCH. The effect of different operational parameters of MW/SPS-treated TCH, such as SPS concentration, TCH concentration, initial pH, and MW power, was investigated. The concentration changes of TCH were determined using a spectrophotometer. The results of radical scavenger experiments indicated that the sulfate radical (SO4 ·-) was stronger than the hydroxyl radical (·OH). On the basis of high performance liquid chromatography-mass spectrometry (HPLC-MS) analysis, a possible degradation pathway of TCH was proposed. This research indicates that the MW/SPS system is a promising prospect for the treatment of TCH.


Assuntos
Tetraciclina , Poluentes Químicos da Água , Micro-Ondas , Oxirredução , Compostos de Sódio , Sulfatos , Poluentes Químicos da Água/análise
11.
Food Funct ; 11(10): 9129-9143, 2020 Oct 21.
Artigo em Inglês | MEDLINE | ID: mdl-33026011

RESUMO

Herein, a sturgeon skin gelatine film combined with esculin and ferric citrate was developed as an edible food packaging material to prevent Enterococcus faecalis (E. faecalis) contamination. E. faecalis is able to hydrolyse esculin in the film, and then the hydrolysed product, esculetin, combines with ferric citrate to form a brown-black phenol iron complex. This phenomenon can be observed easily after 48 h of contamination under visible light, and it can be determined under 365 nm ultraviolet light with high sensitivity. With the addition of esculin and ferric citrate, the film showed better mechanical properties and water vapour permeability than those of the unmodified gelatine. When an increased amount of esculin was added, an increase in thermal stability, antioxidant activity, and antioxidant stability of the film was observed. These physicochemical characteristics are beneficial for developing a packaging material for food storage that mitigates foodborne illness caused by E. faecalis.


Assuntos
Esculina/química , Compostos Férricos/química , Proteínas de Peixes/química , Embalagem de Alimentos/instrumentação , Gelatina/química , Pele/química , Animais , Antibacterianos/química , Antibacterianos/farmacologia , Antioxidantes/química , Antioxidantes/farmacologia , Enterococcus faecalis/efeitos dos fármacos , Enterococcus faecalis/fisiologia , Esculina/farmacologia , Peixes , Contaminação de Alimentos/prevenção & controle , Doenças Transmitidas por Alimentos/microbiologia , Doenças Transmitidas por Alimentos/prevenção & controle , Humanos
12.
Eur J Med Chem ; 206: 112711, 2020 Nov 15.
Artigo em Inglês | MEDLINE | ID: mdl-32810751

RESUMO

This review fully describes the coronavirus 3CLpro peptidomimetic inhibitors and nonpeptidic small molecule inhibitors developed from 2010 to 2020. Specifically, the structural characteristics, binding modes and SARs of these 3CLpro inhibitors are expounded in detail by division into two categories: peptidomimetic inhibitors mainly utilize electrophilic warhead groups to covalently bind the 3CLpro Cys145 residue and thereby achieve irreversible inhibition effects, whereas nonpeptidic small molecule inhibitors mainly interact with residues in the S1', S1, S2 and S4 pockets via hydrogen bonds, hydrophobic bonds and van der Waals forces. Based on the emerging PROTAC technology and the existing 3CLpro inhibitors, 3CLpro PROTAC degraders are hypothesised to be next-generation anti-coronavirus drugs.


Assuntos
Antivirais/farmacologia , Inibidores de Proteases/farmacologia , Proteínas não Estruturais Virais/antagonistas & inibidores , Antivirais/uso terapêutico , Proteases 3C de Coronavírus , Cisteína Endopeptidases , Humanos , Peptidomiméticos , Inibidores de Proteases/uso terapêutico
13.
Mediators Inflamm ; 2020: 3621261, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32684834

RESUMO

Inflammation is a key regulator in the progression of atherosclerosis (AS) which extremely affects people's health. Secoisolariciresinol diglucoside (SDG), a plant lignan, is relevant to angiogenesis and cardioprotection against ischemia-reperfusion injury and improves vascular disorders. However, the effect of SDG on cardiovascular disorder is not clear. In the present study, we aimed to investigate the effects of SDG on lipopolysaccharide- (LPS-) stimulated Human Umbilical Vein Endothelial Cells (HUVECs) and elucidate the underlying mechanism. The LPS-stimulated HUVEC cellular model was established. The cell viability, the cell tube formation activity, the nitric oxide (NO) release, the levels of inflammatory cytokine interleukin-1ß (IL-1ß), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), the activation of nuclear factor kappa-B (NF-κB) pathway, and the expression of protein kinase B (Akt) were determined using Cell Counting Kit-8, cell tube-formation assay, western blotting, and enzyme-linked immunosorbent assay. Our results revealed that SDG reduces the angiogenic capacity of HUVECs and inhibited LPS-mediated HUVEC injury and apoptosis. In addition, SDG increased NO release and decreased the levels of IL-1ß, IL-6, and TNF-α in LPS-treated HUVECs. Meanwhile, SDG inhibited the NF-κB pathway and downregulated Akt expression in LPS-induced HUVECs. Our results indicated that SDG relieves LPS-mediated HUVEC injury by inhibiting the NF-κB pathway which is partly dependent on the disruption of Akt activation. Therefore, SDG exerts its cytoprotective effects in the context of LPS-treated HUVECs via regulation of the Akt/IκB/NF-κB pathway and may be a potential treatment drug for cardiovascular disease.


Assuntos
Butileno Glicóis/farmacologia , Glucosídeos/farmacologia , Células Endoteliais da Veia Umbilical Humana/efeitos dos fármacos , Células Endoteliais da Veia Umbilical Humana/metabolismo , Proteínas I-kappa B/metabolismo , NF-kappa B/metabolismo , Proteínas Proto-Oncogênicas c-akt/metabolismo , Anti-Inflamatórios/farmacologia , Apoptose/efeitos dos fármacos , Humanos , Interleucina-1beta/metabolismo , Interleucina-6/metabolismo , Transdução de Sinais/efeitos dos fármacos , Fator de Necrose Tumoral alfa/metabolismo
14.
Eur J Med Chem ; 201: 112527, 2020 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-32563812

RESUMO

Remdesivir (GS-5734), a viral RNA-dependent RNA polymerase (RdRP) inhibitor that can be used to treat a variety of RNA virus infections, is expected to be an effective treatment for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. On May 1, 2020, The U.S. Food and Drug Administration (FDA) has granted Emergency Use Authorization (EUA) for remdesivir to treat COVID-19 patients. In light of the COVID-19 pandemic, this review presents comprehensive information on remdesivir, including information regarding the milestones, intellectual properties, anti-coronavirus mechanisms, preclinical research and clinical trials, and in particular, the chemical synthesis, pharmacology, toxicology, pharmacodynamics and pharmacokinetics of remdesivir. Furthermore, perspectives regarding the use of remdesivir for the treatment of COVID-19 are also discussed.


Assuntos
Monofosfato de Adenosina/análogos & derivados , Alanina/análogos & derivados , Antivirais/uso terapêutico , Betacoronavirus/efeitos dos fármacos , Infecções por Coronavirus/tratamento farmacológico , Pneumonia Viral/tratamento farmacológico , Monofosfato de Adenosina/uso terapêutico , Alanina/uso terapêutico , COVID-19 , Ensaios Clínicos como Assunto , Infecções por Coronavirus/virologia , Humanos , Pandemias , Pneumonia Viral/virologia , SARS-CoV-2
16.
ACS Appl Mater Interfaces ; 12(21): 24432-24441, 2020 May 27.
Artigo em Inglês | MEDLINE | ID: mdl-32342682

RESUMO

Biofouling is a worldwide problem from healthcare to marine exploration. Aggressive biofouling, wear, and corrosion lead to severe deterioration in function and durability. Here, micro- and nanostructured hierarchical diamond films mimicking the morphology of plant leaves were developed to simultaneously achieve superhydrophobicity, antibacterial efficacy, and marine antibiofouling, combined with mechanical and chemical robustness. These coatings were designed and successfully constructed on various commercial substrates, such as titanium alloys, silicon, and quartz glass via a chemical vapor deposition process. The unique surface structure of diamond films reduced bacteria attachment by 90-99%. In the marine environment, these biomimetic diamond films significantly reduced more than 95% adhesion of green algae. The structured diamond films retained mechanical robustness, superhydrophobicity, and antibacterial efficacy under high abrasion and corrosive conditions, exhibiting at least 20 times enhanced wear resistance than the bare commercial substrates even after long-term immersion in seawater.


Assuntos
Antibacterianos/farmacologia , Incrustação Biológica/prevenção & controle , Materiais Biomiméticos/farmacologia , Materiais Revestidos Biocompatíveis/farmacologia , Diamante/farmacologia , Antibacterianos/química , Materiais Biomiméticos/química , Adesão Celular/efeitos dos fármacos , Chlorella vulgaris/efeitos dos fármacos , Materiais Revestidos Biocompatíveis/química , Diamante/química , Escherichia coli/efeitos dos fármacos , Pseudomonas aeruginosa/efeitos dos fármacos , Molhabilidade
17.
ACS Omega ; 5(10): 5116-5125, 2020 Mar 17.
Artigo em Inglês | MEDLINE | ID: mdl-32201798

RESUMO

Magnetic nanomaterials are promising heterogeneous catalysts for environmental applications. According to X-ray diffraction, Brunauer-Emmett-Teller method, scanning electron microscopy, high-resolution transmission electron microscopy, and vibrating-sample magnetometer, a kind of copper-modified nanomagnetic material (Cu-nFe3O4) was successfully prepared by a one-step synthesis method. Among them, compared with the two-step synthesis method of Cu/Fe3O4 and Cu/nFe3O4, Cu-nFe3O4 has the best effect on chlortetracycline (CTC) removal. The batch study results indicate that the maximum removal of chlortetracycline is 99.0% at a dosage = 2.0 g L-1, copper loading = 0.8 mM, and C 0 = 100 mg L-1 at the optimum conditions within 90 min. The effects of humic acids (HA), NO3 -, Cl-, CO3 2-, and PO4 3- on the CTC removal by Cu-nFe3O4 are also investigated. Repeated experiments were performed on the prepared Cu-nFe3O4, indicating that Cu-nFe3O4 has good recyclability. The kinetics of the Cu-nFe3O4 removal of CTC was investigated, indicating that the reaction conformed to the double constant model and the reaction is mainly dominated by a chemical reaction with physical adsorption. Finally, the mechanism of the CTC removal by Cu-nFe3O4 in a heterogeneous environment was clarified. This study aims to provide an experimental basis for the environmental application of Cu-nFe3O4.

18.
Eur J Med Chem ; 192: 112163, 2020 Apr 15.
Artigo em Inglês | MEDLINE | ID: mdl-32109623

RESUMO

Herein, 11 general types of natural cannabinoids from Cannabis sativa as well as 50 (-)-CBD analogues with therapeutic potential were described. The underlying molecular mechanisms of CBD as a therapeutic candidate for epilepsy and neurodegenerative diseases were comprehensively clarified. CBD indirectly acts as an endogenous cannabinoid receptor agonist to exert its neuroprotective effects. CBD also promotes neuroprotection through different signal transduction pathways mediated indirectly by cannabinoid receptors. Furthermore, CBD prevents the glycogen synthase kinase 3ß (GSK-3ß) hyperphosphorylation caused by Aß and may be developed as a new therapeutic candidate for Alzheimer's disease.


Assuntos
Doença de Alzheimer/tratamento farmacológico , Produtos Biológicos/farmacologia , Canabidiol/uso terapêutico , Epilepsia/tratamento farmacológico , Fármacos Neuroprotetores/uso terapêutico , Doença de Alzheimer/metabolismo , Animais , Produtos Biológicos/química , Canabidiol/química , Cannabis/química , Epilepsia/metabolismo , Humanos , Fármacos Neuroprotetores/química
19.
Chemosphere ; 238: 124543, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31450109

RESUMO

Nano micro-electrolysis materials (nMETs) have been used to degrade refractory pollutants in batch experiments. The reasonable formation mechanism of nMETs was given through DMXY digital biomicroscopy. Based on the kinetic data of Chlortetracycline (CTC) removal by nMETs in batch experiments, combined with the binomial distribution equation of CTC reduction by nano materials an experimental-scale fluidized bed (ESFB) was designed. The effects of CTC removal performance, pH and iron ion concentration were investigated. Under pure CTC solution environment, the experimental data showed that the average removal rates of CTC by nMET and nano micro-electrolysis material with loading copper (Cu-nMET) are 90.0% and 95.7% in ESFB, respectively. In the presence of nitrate, although the consumption of two kinds of nano-materials increased, their removal efficiencies of pollutants have 2.2%, 0.2% increase compared with the nitrate-free ESFB. At the same time, the CTC degradation pathway and the enhanced removal mechanism by Cu-nMET was proposed. Through microelectrolysis reaction, complexation reaction and the active substances produced, the intermediate products can be degraded completely to NH4+, CO2, H2O and so on. This study aims to provide a theoretical basis for the environmental application of nMETs.


Assuntos
Clortetraciclina/isolamento & purificação , Cobre/química , Eletrólise/métodos , Ferro/química , Nitratos/química , Poluentes Químicos da Água/isolamento & purificação , Clortetraciclina/análise , Clortetraciclina/química , Poluentes Químicos da Água/análise , Poluentes Químicos da Água/química
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