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1.
J Nanobiotechnology ; 19(1): 280, 2021 Sep 20.
Artigo em Inglês | MEDLINE | ID: mdl-34544434

RESUMO

BACKGROUND: Electrostimulation (ES) therapy for wound healing is limited in clinical use due to barriers such as cumbersome equipment and intermittent delivery of therapy. METHODS: We adapted a human skin xenograft model that can be used to directly examine the nanogenerator-driven ES (NG-ES) effects on human skin in vivo-an essential translational step toward clinical application of the NG-ES technique for wound healing. RESULTS: We show that NG-ES leads to rapid wound closure with complete restoration of normal skin architecture within 7 days compared to more than 30 days in the literature. NG-ES accelerates the inflammatory phase of wound healing with more rapid resolution of neutrophils and macrophages and enhances wound bed perfusion with more robust neovascularization. CONCLUSION: Our results support the translational evaluation and optimization of the NG-ES technology to deliver convenient, efficient wound healing therapy for use in human wounds.

2.
Science ; 373(6552): 337-342, 2021 07 16.
Artigo em Inglês | MEDLINE | ID: mdl-34437153

RESUMO

Piezoelectric biomaterials are intrinsically suitable for coupling mechanical and electrical energy in biological systems to achieve in vivo real-time sensing, actuation, and electricity generation. However, the inability to synthesize and align the piezoelectric phase at a large scale remains a roadblock toward practical applications. We present a wafer-scale approach to creating piezoelectric biomaterial thin films based on γ-glycine crystals. The thin film has a sandwich structure, where a crystalline glycine layer self-assembles and automatically aligns between two polyvinyl alcohol (PVA) thin films. The heterostructured glycine-PVA films exhibit piezoelectric coefficients of 5.3 picocoulombs per newton or 157.5 × 10-3 volt meters per newton and nearly an order of magnitude enhancement of the mechanical flexibility compared with pure glycine crystals. With its natural compatibility and degradability in physiological environments, glycine-PVA films may enable the development of transient implantable electromechanical devices.


Assuntos
Materiais Biocompatíveis/química , Eletricidade , Glicina/química , Álcool de Polivinil/química , Animais , Sobrevivência Celular , Células Cultivadas , Cristalização , Teoria da Densidade Funcional , Elasticidade , Humanos , Ligação de Hidrogênio , Próteses e Implantes , Ratos , Ratos Sprague-Dawley , Estresse Mecânico
3.
ACS Nano ; 15(9): 14903-14914, 2021 09 28.
Artigo em Inglês | MEDLINE | ID: mdl-34405669

RESUMO

Three-dimensional (3D) ferroelectric materials are electromechanical building blocks for achieving human-machine interfacing, energy sustainability, and enhanced therapeutics. However, current natural or synthetic materials cannot offer both a high piezoelectric response and desired mechanical toughness at the same time to meet the practicality. Here, a lamellar ferroelectric metamaterial was created with a ceramic-like piezoelectric property and a bone-like fracture toughness through a low-voltage-assisted 3D printing technology. The one-step printed bulk structure, consisting of periodically intercalated soft ferroelectric and hard electrode layers, exhibited a significantly enhanced longitudinal piezoelectric charge coefficient (d33) of over 150 pC N-1, as well as a superior fracture resistance of ∼5.5 MPa·m1/2, more than three times higher than conventional piezo-ceramics. The excellent printability together with the combination of both high piezoelectric and mechanical behaviors allowed us to create a bone-like structure with tunable anisotropic piezoelectricity and bone-comparable mechanical properties, showing a potential of manufacturing practical, high-performance, and smart biological systems.


Assuntos
Biomimética , Humanos
4.
Org Lett ; 23(15): 6164-6168, 2021 08 06.
Artigo em Inglês | MEDLINE | ID: mdl-34292759

RESUMO

A Chan-Lam-type C-S coupling reaction using sodium aryl sulfinates has been developed to provide diaryl thioethers in up to 92% yields in the presence of a copper catalyst and potassium sulfite. Both electron-rich and electron-poor sodium aryl sulfinates and diverse organoboron compounds were tolerated for the synthesis of aryl and heteroaryl thioethers and dithioethers. The mechanistic study suggested that potassium sulfite was involved in the deoxygenation of sulfinate through a radical process.

5.
Proc Natl Acad Sci U S A ; 118(28)2021 Jul 13.
Artigo em Inglês | MEDLINE | ID: mdl-34260393

RESUMO

Electrostimulation has been recognized as a promising nonpharmacological treatment in orthopedics to promote bone fracture healing. However, clinical applications have been largely limited by the complexity of equipment operation and stimulation implementation. Here, we present a self-powered implantable and bioresorbable bone fracture electrostimulation device, which consists of a triboelectric nanogenerator for electricity generation and a pair of dressing electrodes for applying electrostimulations directly toward the fracture. The device can be attached to irregular tissue surfaces and provide biphasic electric pulses in response to nearby body movements. We demonstrated the operation of this device on rats and achieved effective bone fracture healing in as short as 6 wk versus the controls for more than 10 wk to reach the same healing result. The optimized electrical field could activate relevant growth factors to regulate bone microenvironment for promoting bone formation and bone remodeling to accelerate bone regeneration and maturation, with statistically significant 27% and 83% improvement over the control groups in mineral density and flexural strength, respectively. This work provided an effective implantable fracture therapy device that is self-responsive, battery free, and requires no surgical removal after fulfilling the biomedical intervention.

7.
Lupus ; 30(9): 1459-1468, 2021 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-34082592

RESUMO

OBJECTIVE: Osteonecrosis (ON), which can lead to physical disability, is a common complication of systemic lupus erythematosus (SLE). The purpose of this study was to determine the prevalence of ON and identify possible risk factors in Chinese SLE patients. METHODS: SLE patients who fulfilled the 1997 American College of Rheumatology SLE classification criteria were recruited from the Peking Union Medical College Hospital. The chi-square test (χ2 test) and multivariate regression analyses were used to evaluate risk factors. The Cox proportional-hazards model was used to construct the survival curves and estimate the simultaneous effects of prognostic factors on survival. RESULTS: We consecutively enrolled 1,158 patients, of which 88 patients (7.6%) developed ON. Among ON patients, 57.1% of patients had isolated femoral head necrosis and 42.9% had multiple joint involvement. The mean age of ON patients (24.62 ± 8.89 years) was significantly younger than SLE patients without ON (27.23 ± 10.16 years, p = 0.09). The ON group presented with a much longer disease course (10.68 ± 5.97 years, p < 0.001) and increased incidence of arthritis, kidney, and central nervous system (CNS) involvement (65.9% [p < 0.05], 57.6% [p < 0.05], and 16.5% [p < 0.05], respectively, in the ON group). ON patients were more likely to be treated with glucocorticoid (GC) and to receive a high dose of prednisolone at the initial stage of SLE (p < 0.05). The percentage of patients who received hydroxychloroquine was much higher in the control group (p < 0.001). Cox regression analysis suggested that CNS involvement and GC therapy were two independent risk factors for ON in SLE patients. The presence of anti-phospholipid antibodies (aPLs) was a risk factor for multiple joint necrosis (odds ratio: 6.28, p = 0.009). CONCLUSIONS: ON remains a serious and irreversible complication in SLE. In addition to glucocorticoid therapy, we found that CNS system involvement was a risk factor for ON, while the administration of hydroxychloroquine was a protective factor. The clinical characteristics of multiple site ON patients were distinct from isolated femoral head necrosis patients. The presence of aPLs was a risk factor for multiple site osteonecrosis.

8.
Adv Sci (Weinh) ; 8(8): 2004023, 2021 04.
Artigo em Inglês | MEDLINE | ID: mdl-33898184

RESUMO

Wearable and implantable electroceuticals (WIEs) for therapeutic electrostimulation (ES) have become indispensable medical devices in modern healthcare. In addition to functionality, device miniaturization, conformability, biocompatibility, and/or biodegradability are the main engineering targets for the development and clinical translation of WIEs. Recent innovations are mainly focused on wearable/implantable power sources, advanced conformable electrodes, and efficient ES on targeted organs and tissues. Herein, nanogenerators as a hotspot wearable/implantable energy-harvesting technique suitable for powering WIEs are reviewed. Then, electrodes for comfortable attachment and efficient delivery of electrical signals to targeted tissue/organ are introduced and compared. A few promising application directions of ES are discussed, including heart stimulation, nerve modulation, skin regeneration, muscle activation, and assistance to other therapeutic modalities.

9.
Appl Energy ; 283: 116339, 2021 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-33753961

RESUMO

With the coronavirus pandemic wreathing havoc around the world, power industry has been hit hard due to the proposal of lockdown policies. However, the impact of lockdowns and shutdowns on the power system in different regions as well as periods of the pandemic can hardly be reflected on the foundation of current studies. In this paper, a prediction-based analysis method is developed to point out the electricity consumption gap resulted from the pandemic situation. The core of this method is a novel optimized grey prediction model, namely Rolling IMSGM(1,1) (Rolling Mechanism combined with grey model with initial condition as Maclaurin series), which achieves better prediction results in the face of long-term emergencies. A novel initial condition is adopted to track data with various characteristics in the form of higher-order polynomials, which are then determined by intelligent algorithms to realize accurate fitting. Historical power consumption data in China are utilized to carry out the monthly forecasts during COVID-19. Compared with other competitive models' prediction results, the superiority of IMSGM(1,1) are demonstrated. Through analyzing the gap between predicted consumption values and the actual data, it can be found that the impact of the pandemic on electricity varies in different periods, which is related to its severity and the local lockdown policies. This study helps to understand the impact on power industry in the face of such an emergency intuitively so as to respond to possible future events.

10.
ACS Appl Mater Interfaces ; 13(12): 14275-14282, 2021 Mar 31.
Artigo em Inglês | MEDLINE | ID: mdl-33729760

RESUMO

Bioresorbable implantable electronics require power sources that are also bioresorbable with controllable electrical output and lifetime. In this paper, we report a bioresorbable zinc primary battery anode filament based on a zinc microparticle (MP) network coated with chitosan and Al2O3 double shells. When discharged in 0.9% NaCl saline, a Zn MP filament with a 0.17 × 2 mm2 cross-sectional area exhibited a stable voltage output of 0.55 V at a current of 0.01 mA. Covered by chitosan and Al2O3 double shells, the zinc MP filament exhibited a directional dissolution behavior with a tunable lifetime approximately linear to its length. A stable 200 h discharging time was achieved with a 15 mm Zn MP filament. The maximum output power was found to be 12 µW at 0.03 mA for one filament. The linearity relationship between the current output and the filament cross-sectional area suggested a facile strategy to raise the power output at constant discharging voltage. The filaments could also be connected in series and in parallel to boost its overall voltage and current output, demonstrating their excellent integration capability. This work presents a promising pathway toward bioresorbable transient batteries with controllable lifetime and power output, demonstrating a great potential for powering transient implantable biomedical devices.

11.
Clin Exp Rheumatol ; 39(4): 889-898, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33635227

RESUMO

Systemic lupus erythematosus (SLE) is a complex and challenging disorder. At present, abnormal T cells are considered to be the key point in the pathogenesis of SLE, including the losing central immune tolerance of self-reactive T cells in the thymus, breaking of regulatory T cell balances, and the overactivation of pro-inflammatory T cells. The alterations of T-cell receptor proteins are closely related to these abnormal changes. Glycosylation is one of the most ubiquitous steps of protein post-translational modification. Especially the modifications of N-glycans and O-glycans on T-cell surfaces have been found to regulate apoptosis and downstream signalling in SLE. Accordingly, this review summarises the aberrant modulate effects of T cell glycosylation in SLE and provides new insights into understanding the pathogenesis and some potential therapeutic targets of this chronic autoimmune disease.


Assuntos
Doenças Autoimunes , Lúpus Eritematoso Sistêmico , Glicosilação , Humanos , Polissacarídeos , Processamento de Proteína Pós-Traducional
12.
ACS Appl Mater Interfaces ; 13(4): 5133-5141, 2021 Feb 03.
Artigo em Inglês | MEDLINE | ID: mdl-33471495

RESUMO

Cellulose-based materials have gained increasing attention for the development of low-cost, eco-friendly technologies, and more recently, as functional materials in triboelectric nanogenerators (TENGs). However, the low output performance of cellulose-based TENGs severely restricts their versatility and employment in emerging smart building and smart city applications. Here, we report a high output performance of a commercial cellulosic material-based energy harvesting floor (CEHF). Benefiting from the significant difference in the triboelectric properties between weighing and nitrocellulose papers, high surface roughness achieved by a newly developed mechanical exfoliation method, and large overall contact area via a multilayered device structure, the CEHF (25 cm × 15 cm × 1.2 cm) exhibits excellent output performance with a maximum output voltage, current, and power peak values of 360 V, 250 µA, and 5 mW, respectively. It can be directly installed or integrated with regular flooring products to effectively convert human body movements into electricity and shows good durability and stability. Moreover, a wireless transmission sensing system that can produce a 1:1 footstep-to-signal (transmitted and received) ratio is instantaneously powered by a TENG based entirely on cellulosic materials for the first time. This work provides a feasible and effective way to utilize commercial cellulosic materials to construct self-powered wireless transmission systems for real-time sensing applications.

13.
Analyst ; 146(5): 1656-1662, 2021 Mar 08.
Artigo em Inglês | MEDLINE | ID: mdl-33514956

RESUMO

Triboelectric nanogenerators (TENGs) have attracted many research endeavors as self-powered sensors for force, velocity, and gas detection based on solid-solid or solid-air interactions. Recently, triboelectrification at liquid-solid interfaces also showed intriguing capability in converting physical contacts into electricity. Here, we report a self-powered triboelectric sensor for liquid chemical sensing based on liquid-solid electrification. As a liquid droplet passed across the tribo-negative sensor surface, the induced surface charge balanced with the electrical double layer charge in the liquid droplet. The competition between the double layer charge and surface charge generated characteristic positive and negative voltage spikes, which may serve as a "binary feature" to identify the chemical compound. The sensor showed distinct sensitivity to three amino acids including glycine, lysine and phenylalanine as a function of their concentration. The versatile sensing ability was further demonstrated on several other inorganic and organic chemical compounds dissolved in DI water. This work demonstrated a promising sensing application based on the triboelectrification principle for biofluid sensor development.

14.
Mod Rheumatol ; 31(4): 875-884, 2021 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-32946311

RESUMO

METHODS: Baseline and follow-up DECTs were performed under a standard ULT protocol. Monthly dissolution rates were calculated by simple and compound methods. Correlations with average SU were compared and analyzed. Best-fit regression model was identified. MSU dissolution times were plotted against SU at different endpoints. RESULTS: In 29 tophaceous gout patients, MSU volume reduced from baseline 10.94 ± 10.59 cm3 to 2.87 ± 5.27 cm3 on follow-up (p = .00). Dissolution rate had a stronger correlation with SU if calculated by compound method (Pearson's correlation coefficient r= -0.77, p = .00) and was independent of baseline MSU load. The ensuing dissolution model was logarithmic and explained real-life scenarios. When SU > 0.43 mmol/l, dissolution time approached infinity. It improved to 10-19 months at SU = 0.24 mmol/l. When SU approximated zero (as with pegloticase), dissolution flattened and still took 4-8 months. CONCLUSION: MSU dissolution is better described as a logarithmic function of SU, which explains, predicts, and facilitates understanding of the dissolution process.

15.
Hum Cell ; 33(4): 1142-1154, 2020 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-32776307

RESUMO

Long noncoding RNAs (lncRNAs) are abnormally expressed in many malignant tumors and involved in regulating the malignant phenotypes of cancer cells. However, the role of LINC00665 in colorectal cancer (CRC) and its regulatory mechanism remain unclear. In this study, real-time polymerase chain reaction (RT-PCR) was used to detect the expressions of LINC00665, miR-9-5p and activating transcription factor 1 (ATF1) mRNA in CRC tissues. The expression of ATF1 in CRC tissues was also detected by immunohistochemistry and Western blot. CCK-8 and colony formation assays were employed to detect cell proliferation. Cell cycle and apoptosis were detected by flow cytometry analysis. Scratch healing assay and Transwell test were exploited to detect cell migration and invasion. The targeting relationships between LINC00665 and miR-9-5p, and miR-9-5p and ATF1 were validated by dual luciferase reporter assay. We found that LINC00665 was significantly overexpressed in CRC tissues, and it was also negatively correlated with the expression of miR-9-5p and positively associated with the expression of ATF1. Besides, LINC00665 promoted the proliferation, migration and invasion of CRC cells, and inhibited cell apoptosis by sponging miR-9-5p. ATF1 was proved to be the downstream target of miR-9-5p and was indirectly regulated by LINC00665. Collectively, it is concluded that LINC00665 contributes to the progression of CRC by regulating miR-9-5p/ATF1 axis.


Assuntos
Fator 1 Ativador da Transcrição/genética , Fator 1 Ativador da Transcrição/metabolismo , Proliferação de Células/genética , Neoplasias Colorretais/genética , Neoplasias Colorretais/patologia , Regulação Neoplásica da Expressão Gênica/genética , Expressão Gênica/genética , MicroRNAs/genética , MicroRNAs/metabolismo , RNA Longo não Codificante/genética , RNA Longo não Codificante/fisiologia , Apoptose/genética , Ciclo Celular , Linhagem Celular Tumoral , Movimento Celular/genética , Neoplasias Colorretais/metabolismo , Progressão da Doença , Marcação de Genes , Humanos , Invasividade Neoplásica/genética , RNA Longo não Codificante/metabolismo
16.
Nano Lett ; 20(9): 6510-6519, 2020 09 09.
Artigo em Inglês | MEDLINE | ID: mdl-32786929

RESUMO

Hepatic ischemia-reperfusion injury (IRI), which mainly results from excessive reactive oxygen species (ROS) generated by a reperfusion burst of oxygen, has long been a major cause of liver dysfunction and failure after surgical procedures. Here, a monodispersed hydrophilic carbohydrate-derived nanoparticle (C-NP) was synthesized as a nanoantioxidant that could effectively prevent hepatic IRI. The spherical C-NPs had a size of ∼78 ± 11.3 nm covered with polar surface groups. They were well dispersible in water with good colloidal stability, nontoxicity, and good ROS scavenging capability. The C-NPs also exhibited good circulation lifetime, effective delivery to liver, and gradual degradability with an ability to assist the IRI group maintaining a normal and healthy liver status. The pathology mechanism of C-NPs in hepatic IRI was confirmed to be scavenging of excessive ROS by C-NPs. The effective therapeutic treatment of C-NPs in living animals revealed a great potential in clinical prevention for hepatic IRI.


Assuntos
Nanopartículas , Traumatismo por Reperfusão , Animais , Carboidratos , Fígado , Espécies Reativas de Oxigênio , Traumatismo por Reperfusão/tratamento farmacológico , Traumatismo por Reperfusão/prevenção & controle
17.
J Adolesc ; 83: 62-71, 2020 08.
Artigo em Inglês | MEDLINE | ID: mdl-32745793

RESUMO

INTRODUCTION: The present study calls attention to the longitudinal relations between mothers', fathers', and adolescents' emotion dysregulation and adolescents' internalizing problems. To this end, we tested the associations between family members' emotion dysregulation and adolescents' internalizing problems over time. METHODS: Over a 12-month period, 386 Chinese families from Hong Kong involving mothers, fathers, and adolescent children (children at 12-17 years of age; boys = 185, girls = 201) completed a set of questionnaires twice. RESULTS: Multi-group path analysis revealed unidirectional effects of mothers' emotion dysregulation on fathers' and adolescents' emotion dysregulation over time. Adolescents' emotion dysregulation was also related to their subsequent internalizing problems. The associations did not differ as a function of adolescents' gender. CONCLUSION: The present findings underscore the significance of mothers' emotion dysregulation on fathers' and adolescents' emotion dysregulation. As a risk factor, adolescents' emotion dysregulation was also predictive of their internalizing problems 12 months later. Taken together, this study serves to inform prevention and intervention efforts in promoting emotion regulation as a family asset associated with fewer adolescents' internalizing problems.


Assuntos
Comportamento do Adolescente/psicologia , Mecanismos de Defesa , Regulação Emocional , Relações Familiares/psicologia , Adolescente , Adulto , Criança , Pai/psicologia , Feminino , Hong Kong , Humanos , Estudos Longitudinais , Masculino , Mães/psicologia , Inquéritos e Questionários
18.
Zhongguo Zhong Yao Za Zhi ; 45(11): 2552-2559, 2020 Jun.
Artigo em Chinês | MEDLINE | ID: mdl-32627488

RESUMO

Scutellariae Radix(Huangqin) is a well-known traditional Chinese medicine(TCM) used for the treatment of clearing heat in clinical application. It is bitter-cold by using directly, but the bitter-cold property can be relieved after wine-frying. The study of taste changes before and after wine-frying of Scutellariae Radix is of great significance in identifying Scutellariae Radix and wine-processed Scutellariae Radix and clarifying the traditional theory of wine-processing. In this experiment, 10 batches of Scutellariae Radix and wine-processed Scutellariae Radix were prepared. The contents of 5 flavonoids were determined by high performance liquid chromatography(HPLC), and principal component analysis(PCA) was performed with 5 flavonoids as variables. As a result, the contents were different in different batches of Scutellariae Radix, but Scutellariae Radix and wine-processed Scutellariae Radix could not be distinguished. Five sensory attributes(sour, salty, fresh, sweet, and bitter) were evaluated by artificial tasting, and the response values of 7 sensors(AHS, AHS, PKS, CTS, NMS, CPS, ANS, SCS) representing the taste of pieces were detected by electronic tongue. The correlation between sensory evaluation and response values of the electronic tongue were analyzed, and the results showed that the sensory evaluation of sour, salty, fresh, sweet, bitter and AHS, CTS, NMS, ANS, SCS sensors had different degrees of correlation, indicating that the electronic tongue technology can be used as an alternative to artificial taste and can serve as a means for quantifying the taste, and it can be used to evaluate the taste of TCM pieces. The taste method was used to analyze the response values of the electronic tongue, and the results showed that the bitterness of wine-processed Scutellariae Radix decreased and the salty taste increased. PCA was used to analyze taste changes before and after wine-processed Scutellariae Radix, and the results showed that taste differences between 2 pieces were divided into 2 categories. PCA loading scattering plots showed that response of saltiness and bitterness were the major factors to affect overall taste in Scutellariae Radix and wine-processed Scutellariae Radix. Based on electronic tongue response values, the Fisher discriminant model for Scutellariae Radix and wine-processed Scutellariae Radix was established, which showed that it could effectively discriminate them with a recognition rate of 100%. The experimental results showed that the electronic tongue combined with multivariate statistical analysis can be used to evaluate taste of TCM, at the same time, it could provide a fast and simple method for identifying different processed products.


Assuntos
Scutellaria baicalensis , Vinho/análise , Cromatografia Líquida de Alta Pressão , Medicina Tradicional Chinesa , Paladar
19.
Sci Data ; 7(1): 233, 2020 07 13.
Artigo em Inglês | MEDLINE | ID: mdl-32661260

RESUMO

In the wake of the Fukushima nuclear disaster, Japan largely moved away from nuclear power generation and turned back towards an energy sector dominated by fossil fuels. As a result, the pace towards reaching emission reduction targets has largely slowed down. This situation indicates that higher emissions will continue to be generated if there is no appropriate and efficient measurement implemented to bridge the energy demand gap. To contribute adequate mitigation policies, a detailed inventory of both CO2 emissions and socioeconomic factors, both at the national and regional level, should be issued. Thereby, this work contributes to a time-series emission with a record of 47 prefectures in Japan as well as their associated socioeconomic features. The compiled emission inventory is based on three major fossil fuels and 26 sectors with careful emission allocations for regional electricity generation. This dataset is uniformly formatted and can be expected to provide vital information to set regional reduction allowances and sectoral reduction priorities.

20.
J Environ Manage ; 270: 110750, 2020 Sep 15.
Artigo em Inglês | MEDLINE | ID: mdl-32507735

RESUMO

Recent years, the energy consumption and carbon emissions released from the residential sector have increased rapidly due to the improvement of living standards. Japan, as one of the most developed countries worldwide, is found to be the fourth largest CO2 emitter in the world. Meanwhile, Japan is currently promoting social electrification from varied aspects. And this action further brings the household residential consumption to the vital place for overall energy conservation and emission reduction plans. Although electricity consumption and prediction analysis have been widely discussed. However, previous studies mainly focused on the estimation and analysis of energy consumption at the national level, without enough discussion from prefecture-level insights. To bridge this knowledge gap, this study established a factor-based bottom-up model to estimate the electricity consumption and carbon emissions during the 2015-2040 periods in the Japanese residential sector, considering the prefectural characteristics including per capita gross domestic product, population size, household size, residential floor space area, lifestyle, weather condition, and transition effect of appliance in the future. Nine scenarios that combine three levels of household size and three levels of growth of per capita gross domestic product are taken into account to estimate the electricity consumption for space heating and cooling, water heating, cooking, and appliances. Results indicate that the total residential electricity consumption will reach a peak during 2020s. The total carbon emissions will keep decreasing by 51.14-72.16 Mt between 2015 and 2040. Based on the results of this paper, policy recommendations are given for the Japanese government.


Assuntos
Dióxido de Carbono/análise , Eletricidade , Produto Interno Bruto , Calefação , Japão
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