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1.
Nanoscale ; 11(46): 22475-22481, 2019 Nov 28.
Artigo em Inglês | MEDLINE | ID: mdl-31746908

RESUMO

Silver nanowires (AgNWs), as one of the most important plasmonic waveguides, can support several different plasmonic modes. These surface plasmon polariton (SPP) modes have different electric field distributions, effective mode areas, propagation lengths and losses and thus can be used for different applications, from efficiently collecting single photons to carrying quantum entanglement. Therefore, the excitation and analysis of these different SPP modes are of pivotal importance for the development of subwavelength optical devices. In this work, we investigate different SPP modes on a suspended AgNW adhered to a fiber taper. Theoretical simulations and experimental results show that the desired SPP modes can be selectively excited by adjusting either the polarization of the excitation light or the coupling length between the fiber taper and the AgNW. Moreover, fundamental and higher-order SPP modes can be distinguished by means of a far-field method. Our results not only enable convenient and controllable excitation of the desired SPP modes but also provide unique insight into the optical properties of plasmonic waveguides.

2.
Water Sci Technol ; 79(10): 1947-1955, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-31294711

RESUMO

Developing substrate with carbon release properties is helpful to enhance nitrogen removal in low C/N ratio wastewater treatment. In this study, substrates with and without adding carbon source and microorganism were prepared to treat the drainage effluent from a wastewater treatment plant (WWTP), the difference in nitrogen removal were investigated. The results showed that adding a carbon source and microorganism to substrates could not only increase the amount of chemical oxygen demand (COD) released, but also enhance the adsorption capacities of NH4+-N and NO3--N. The carbon release process followed the first-order kinetic equation. A nitrogen removal model consisting of four phases of diffusion, adsorption, assimilation and transformation was proposed. In the short term, nitrogen was mainly removed by adsorption; adding microorganism contributed to enhance nitrification and denitrification. In the long-term, nitrogen removal performances were similar whether microorganism was added or not, and microbial species on the surface of substrates were similar. This work suggested when using substrate to treat wastewater for nitrogen removal, preparing a substrate with excellent property for biofilm formation was the most important factor.


Assuntos
Nitrogênio , Eliminação de Resíduos Líquidos , Águas Residuárias , Biodegradação Ambiental , Carbono , Desnitrificação , Microbiologia da Água
3.
BMC Genomics ; 20(1): 514, 2019 Jun 21.
Artigo em Inglês | MEDLINE | ID: mdl-31226927

RESUMO

BACKGROUND: Polyploidization, pervasive among higher plant species, enhances adaptation to water deficit, but the physiological and molecular advantages need to be investigated widely. Long non-coding RNAs (lncRNAs) are involved in drought tolerance in various crops. RESULTS: Herein, we demonstrate that tetraploidy potentiates tolerance to drought stress in cassava (Manihot esculenta Crantz). Autotetraploidy reduces transpiration by lesser extent increasing of stomatal density, smaller stomatal aperture size, or greater stomatal closure, and reducing accumulation of H2O2 under drought stress. Transcriptome analysis of autotetraploid samples revealed down-regulation of genes involved in photosynthesis under drought stress, and less down-regulation of subtilisin-like proteases involved in increasing stomatal density. UDP-glucosyltransferases were increased more or reduced less in dehydrated leaves of autotetraploids compared with controls. Strand-specific RNA-seq data (validated by quantitative real time PCR) identified 2372 lncRNAs, and 86 autotetraploid-specific lncRNAs were differentially expressed in stressed leaves. The co-expressed network analysis indicated that LNC_001148 and LNC_000160 in autotetraploid dehydrated leaves regulated six genes encoding subtilisin-like protease above mentioned, thereby result in increasing the stomatal density to a lesser extent in autotetraploid cassava. Trans-regulatory network analysis suggested that autotetraploid-specific differentially expressed lncRNAs were associated with galactose metabolism, pentose phosphate pathway and brassinosteroid biosynthesis, etc. CONCLUSION: Tetraploidy potentiates tolerance to drought stress in cassava, and LNC_001148 and LNC_000160 mediate drought tolerance by regulating stomatal density in autotetraploid cassava.


Assuntos
Aclimatação/genética , Manihot/genética , RNA Longo não Codificante/fisiologia , RNA de Plantas/fisiologia , Secas , Perfilação da Expressão Gênica , Regulação da Expressão Gênica de Plantas , Manihot/fisiologia , Fotossíntese/genética , Estômatos de Plantas/genética , Estômatos de Plantas/fisiologia , Estresse Fisiológico , Tetraploidia
4.
Blood Adv ; 3(10): 1610-1621, 2019 May 28.
Artigo em Inglês | MEDLINE | ID: mdl-31126916

RESUMO

In chronic-phase chronic myeloid leukemia (CP-CML) patients treated with frontline imatinib, failure to achieve early molecular response (EMR; EMR failure: BCR-ABL1 >10% on the international scale at 3 months) is predictive of inferior outcomes. Identifying patients at high-risk of EMR failure at diagnosis provides an opportunity to intensify frontline therapy and potentially avoid EMR failure. We studied blood samples from 96 CP-CML patients at diagnosis and identified 365 genes that were aberrantly expressed in 13 patients who subsequently failed to achieve EMR, with a gene signature significantly enriched for stem cell phenotype (eg, Myc, ß-catenin, Hoxa9/Meis1), cell cycle, and reduced immune response pathways. We selected a 17-gene panel to predict EMR failure and validated this signature on an independent patient cohort. Patients classified as high risk with our gene expression signature (HR-GES) exhibited significantly higher rates of EMR failure compared with low-risk (LR-GES) patients (78% vs 5%; P < .0001), with an overall accuracy of 93%. Furthermore, HR-GES patients who received frontline nilotinib had a relatively low rate of EMR failure (10%). However, HR-GES patients still had inferior deep molecular response achievement rate by 24 months compared with LR-GES patients. This novel multigene signature may be useful for selecting patients at high risk of EMR failure on standard therapy who may benefit from trials of more potent kinase inhibitors or other experimental approaches.

5.
Nanotechnology ; 30(30): 305401, 2019 Jul 26.
Artigo em Inglês | MEDLINE | ID: mdl-30970328

RESUMO

Colloidal Au nanoparticles (NPs) were decorated on stainless steel for surface plasmon enhanced laser ablation. A comparative study of the laser ablation efficiency was carried out on stainless steel samples with and without the Au NPs decoration at a variable pulsed laser fluence and laser pulse number. Higher ablation efficiency was clearly demonstrated in the former as illustrated from the larger diameter, maximum depth and the cross-sectional area of the crater generated by the laser ablation under the same conditions. Additionally, both the maximum depth and efficiency enhancement were found to depend on the laser fluence and pulse number. The maximum enhanced ablation efficiency of 36% based on the cross-sectional area of the crater was obtained at 1 pulse number of laser fluence 1.53 J cm-2. The efficiency enhancement of laser ablation is attributed to the highly enhanced surface plasmon field at the interface between Au NPs and stainless steel.

6.
J Asian Nat Prod Res ; : 1-8, 2019 Mar 19.
Artigo em Inglês | MEDLINE | ID: mdl-30887830

RESUMO

A series of aromatic or long-chain chrysin derivatives (1-10) were synthesized by esterification of chrysin and acyl chloride. The chemical structures of these compounds were determined by mass spectrum (MS), 1H NMR, and 13C NMR spectra. Though aromatic chrysin derivatives (1-9) with a rigid structure were hard to dissolve in common organic solvents, the long-chain chrysin derivative (10) with a flexible structure had better solubility, and its anticancer activity (IC50 = 14.79 µmol/L) against liver cancer cell lines was 5.4 times better than chrysin (IC50 = 74.97 µmol/L), which showed superposition of pharmacological activity.

7.
Plant Dis ; 103(5): 868-873, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-30856075

RESUMO

Resistance to maize rough dwarf disease (MRDD), a major cause of crop losses, depends on external conditions such as the virus transmission period and the rate of viruliferous small brown planthoppers, Laodelphax striatellus. The precise identification of MRDD contributes to the utilization of resistant germplasm and the cloning of resistant genes. In this study, eight maize varieties were artificially inoculated in a greenhouse with viruliferous planthoppers. The viral titers in maize seedlings were detected by quantitative fluorescence RT-PCR, and the viral replication curves were analyzed by regression. A logistic model fit the Rice black-streaked dwarf virus (RBSDV) replication data for five susceptible varieties well, whereas a linear model fit the data for three resistant varieties. Among the five susceptible varieties, the time points with the maximum replication rates (tIP) of the highly susceptible Ye478 and XH6 were significantly earlier than those of the three susceptible varieties, Mo17, Zheng58, and Zhengdan958. P138, the most highly resistant variety, had the lowest slope of the best fit line, followed by moderately resistant Chang7-2 and Dan 340. The RBSDV replication curve model developed in this study can accurately identify the resistance of maize germplasm to MRDD at the molecular level. Our results also suggested that tIP and the slope of the RBSDV replication curve can be considered new criteria to evaluate maize resistance to MRDD.


Assuntos
Resistência à Doença , Hemípteros , Modelos Teóricos , Replicação Viral , Zea mays , Animais , Resistência à Doença/genética , Hemípteros/virologia , Doenças das Plantas/genética , Doenças das Plantas/virologia , Reoviridae/fisiologia , Replicação Viral/fisiologia , Zea mays/virologia
8.
Pest Manag Sci ; 75(6): 1726-1733, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-30525307

RESUMO

BACKGROUND: Insecticides act as toxins, inhibitors of digestion and deterrents, and affect the expression of many genes in insects. To assess key genes associated with the detoxification or regulation of imidacloprid in greenbug, Schizaphis graminum (Rondani), the transcriptome and digital gene expression (DGE) profile were analyzed using Illumina sequencing. RESULTS: In total, 48 763 494 clean reads were obtained by sequencing. Expression profile analysis showed that 2782 unigenes were differently expressed between the imidacloprid treatment and control groups. After exposure to imidacloprid, the expression levels of 1846 unigenes were upregulated and 936 were downregulated in comparison with controls. Expression patterns of the top 20 highly expressed genes show that they could be involved in the detoxification of imidacloprid. Silencing of multidrug resistance-associated gene (MRA), GATA-binding gene (GAT) and takeout-like precursor gene (TLP) resulted in increasing susceptibility to imidacloprid. CONCLUSIONS: The differentially expressed genes in S. graminum have potential regulatory or detoxification roles in response to imidacloprid. These results should be useful in understanding the molecular mechanisms of greenbug adaption to imidacloprid. © 2018 Society of Chemical Industry.


Assuntos
Hemípteros/efeitos dos fármacos , Hemípteros/genética , Inseticidas/farmacologia , Neonicotinoides/farmacologia , Nitrocompostos/farmacologia , Interferência de RNA , Transcriptoma/efeitos dos fármacos , Animais , Hemípteros/metabolismo , Inativação Metabólica , Proteínas de Insetos/deficiência , Proteínas de Insetos/genética
9.
Oncotarget ; 9(78): 34735-34747, 2018 Oct 05.
Artigo em Inglês | MEDLINE | ID: mdl-30410673

RESUMO

TKI resistance remains a major impediment to successful treatment of CML. In this study, we investigated the emerging modes of ponatinib resistance in TKI-naïve and dasatinib resistant BCR-ABL1+ cell lines. To investigate potential resistance mechanisms, ponatinib resistance was generated in BCR-ABL1+ cell-lines by long-term exposure to increasing concentrations of ponatinib. Two cell lines with prior dasatinib resistance demonstrated BCR-ABL1 kinase domain (KD) mutation(s) upon exposure to ponatinib. In one of these cell lines the T315I mutation had emerged during dasatinib exposure. When further cultured with ponatinib, the T315I mutation level and BCR-ABL1 mRNA expression level were increased. In the other cell line, compound mutations G250E/E255K developed with ponatinib exposure. In contrast, the ponatinib resistant cell lines that had no prior exposure to other TKIs (TKI-naïve) did not develop BCR-ABL1 KD mutations. Rather, both of these cell lines demonstrated Bcr-Abl-independent resistance via Axl overexpression. Axl, a receptor tyrosine kinase, has previously been associated with imatinib and nilotinib resistance. Ponatinib sensitivity was restored following Axl inhibition or shRNA-mediated-knockdown of Axl, suggesting that Axl was the primary driver of resistance and a potential target for therapy in this setting.

10.
IEEE Trans Cybern ; 48(10): 2962-2971, 2018 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-28976329

RESUMO

This paper investigates the adaptive output regulation problem for heterogeneous linear multiagent systems under randomly switching communication topologies. The switching mechanism is governed by a time-homogeneous Markov process, whose states correspond to all possible communication topologies among agents. A novel distributed adaptive cooperative controller is presented, where the dynamic compensators are utilized to estimate the exogenous signal for all the agents in mean square sense. The distributed control law is based upon the local information of agents, without using the global information of the communication topologies. Finally, illustrative examples are put forward to demonstrate the effectiveness of the given control scheme.

11.
IEEE Trans Cybern ; 47(8): 1820-1829, 2017 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-28541918

RESUMO

This paper studies the consensus problem of heterogeneous linear multiagent systems with arbitrarily large constant, time-varying, or distributed communication delays. Novel distributed dynamic controllers are proposed for such multiagent systems with fixed and switching directed communication topologies, respectively. It is shown that the controlled heterogeneous linear multiagent system can reach consensus for arbitrarily large constant, time-varying, and distributed communication delays under some sufficient conditions. Simulation examples are provided to demonstrate the effectiveness of the proposed controllers.

12.
Acta Pharmacol Sin ; 38(9): 1236-1247, 2017 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-28552908

RESUMO

Xyloketal B (Xyl-B) is a novel marine compound isolated from mangrove fungus Xylaria sp. We previously demonstrated that pretreatment with Xyl-B exerted neuroprotective effects and attenuated hypoxic-ischemic brain injury in neonatal mice. In the present study we investigated the neuroprotective effects of pre- and post-treatment with Xyl-B in adult mice using a transient middle cerebral artery occlusion (tMCAO) model, and explored the underlying mechanisms. Adult male C57 mice were subjected to tMCAO surgery. For the pre-treatment, Xyl-B was given via multiple injections (12.5, 25, and 50 mg·kg-1·d-1, ip) 48 h, 24 h and 30 min before ischemia. For the post-treatment, a single dose of Xyl-B (50 mg/kg, ip) was injected at 0, 1 or 2 h after the onset of ischemia. The regional cerebral perfusion was monitored using a laser-Doppler flowmeter. TTC staining was performed to determine the brain infarction volume. We found that both pre-treatment with Xyl-B (50 mg/kg) and post-treatment with Xyl-B (50 mg/kg) significantly reduced the infarct volume, but had no significant hemodynamic effects. Treatment with Xyl-B also significantly alleviated the neurological deficits in tMCAO mice. Furthermore, treatment with Xyl-B significantly attenuated ROS overproduction in brain tissues; increased the MnSOD protein levels, suppressed TLR4, NF-κB and iNOS protein levels; and downregulated the mRNA levels of proinflammatory cytokines, including IL-1ß, TNF-α, IL-6 and IFN-γ. Moreover, Xyl-B also protected blood-brain barrier integrity in tMCAO mice. In conclusion, Xyl-B administered within 2 h after the onset of stroke effectively protects against focal cerebral ischemia; the underlying mechanism may be related to suppressing the ROS/TLR4/NF-κB inflammatory signaling pathway.


Assuntos
Infarto Cerebral/tratamento farmacológico , Modelos Animais de Doenças , Infarto da Artéria Cerebral Média/tratamento farmacológico , Inflamação/tratamento farmacológico , Piranos/farmacologia , Transdução de Sinais/efeitos dos fármacos , Acidente Vascular Cerebral/tratamento farmacológico , Animais , Infarto Cerebral/metabolismo , Infarto da Artéria Cerebral Média/metabolismo , Inflamação/metabolismo , Masculino , Camundongos , Camundongos Endogâmicos C57BL , NF-kappa B/metabolismo , Piranos/administração & dosagem , Piranos/química , Espécies Reativas de Oxigênio/metabolismo , Receptor 4 Toll-Like/metabolismo
13.
Haematologica ; 102(5): 843-853, 2017 05.
Artigo em Inglês | MEDLINE | ID: mdl-28154092

RESUMO

Imatinib is actively transported by organic cation transporter-1 (OCT-1) influx transporter, and low OCT-1 activity in diagnostic chronic myeloid leukemia blood mononuclear cells is significantly associated with poor molecular response to imatinib. Herein we report that, in diagnostic chronic myeloid leukemia mononuclear cells and BCR-ABL1+ cell lines, peroxisome proliferator-activated receptor γ agonists (GW1929, rosiglitazone, pioglitazone) significantly decrease OCT-1 activity; conversely, peroxisome proliferator-activated receptor γ antagonists (GW9662, T0070907) increase OCT-1 activity. Importantly, these effects can lead to corresponding changes in sensitivity to BCR-ABL kinase inhibition. Results were confirmed in peroxisome proliferator-activated receptor γ-transduced K562 cells. Furthermore, we identified a strong negative correlation between OCT-1 activity and peroxisome proliferator-activated receptor γ transcriptional activity in diagnostic chronic myeloid leukemia patients (n=84; P<0.0001), suggesting that peroxisome proliferator-activated receptor γ activation has a negative impact on the intracellular uptake of imatinib and consequent BCR-ABL kinase inhibition. The inter-patient variability of peroxisome proliferator-activated receptor γ activation likely accounts for the heterogeneity observed in patient OCT-1 activity at diagnosis. Recently, the peroxisome proliferator-activated receptor γ agonist pioglitazone was reported to act synergistically with imatinib, targeting the residual chronic myeloid leukemia stem cell pool. Our findings suggest that peroxisome proliferator-activated receptor γ ligands have differential effects on circulating mononuclear cells compared to stem cells. Since the effect of peroxisome proliferator-activated receptor γ activation on imatinib uptake in mononuclear cells may counteract the clinical benefit of this activation in stem cells, caution should be applied when combining these therapies, especially in patients with high peroxisome proliferator-activated receptor γ transcriptional activity.


Assuntos
Proteínas de Fusão bcr-abl/antagonistas & inibidores , Mesilato de Imatinib/farmacologia , Leucemia Mielogênica Crônica BCR-ABL Positiva/metabolismo , Leucócitos Mononucleares/efeitos dos fármacos , PPAR gama/metabolismo , Antineoplásicos/farmacocinética , Antineoplásicos/farmacologia , Linhagem Celular Tumoral , Células Cultivadas , Proteínas de Fusão bcr-abl/genética , Proteínas de Fusão bcr-abl/metabolismo , Regulação Leucêmica da Expressão Gênica , Células HL-60 , Humanos , Mesilato de Imatinib/farmacocinética , Células K562 , Leucemia Mielogênica Crônica BCR-ABL Positiva/genética , Leucemia Mielogênica Crônica BCR-ABL Positiva/patologia , Leucemia Mieloide de Fase Crônica/genética , Leucemia Mieloide de Fase Crônica/metabolismo , Leucemia Mieloide de Fase Crônica/patologia , Leucócitos Mononucleares/metabolismo , Transportador 1 de Cátions Orgânicos/genética , Transportador 1 de Cátions Orgânicos/metabolismo , PPAR gama/agonistas , PPAR gama/antagonistas & inibidores
14.
IEEE Trans Cybern ; 47(8): 1914-1924, 2017 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-28113390

RESUMO

This paper addresses the output consensus problem of heterogeneous linear multi-agent systems. We first propose a novel distributed event-triggered control scheme. It is shown that, with the proposed control scheme, the output consensus problem can be solved if two matrix equations are satisfied. Then, we further propose a novel self-triggered control scheme, with which continuous monitoring is avoided. By introducing a fixed timer into both event- and self-triggered control schemes, Zeno behavior can be ruled out for each agent. The effectiveness of the event- and self-triggered control schemes is illustrated by an example.

15.
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi ; 29(5): 651-655, 2017 Jul 06.
Artigo em Chinês | MEDLINE | ID: mdl-29469372

RESUMO

The monitoring and control of malaria depends largely on the spatial analysis technology and mathematical models. Visualization of malaria situation is the most popular way to present how malaria transmits. In this paper, the malaria epidemic situation and the application of spatial epidemiology of malaria in China are summarized, so as to provide the systematic epidemiological information for malaria elimination in China.


Assuntos
Malária/epidemiologia , China/epidemiologia , Epidemias , Humanos , Malária/prevenção & controle , Modelos Teóricos , Análise Espacial
16.
Pharmazie ; 72(4): 205-208, 2017 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-29441988

RESUMO

BACKGROUND: It has been previously demonstrated that conjugation of paclitaxel to a linear poly(l-γ-glutamylglutamine) backbone can enhance water solubility of paclitaxel. However, intratumoral penetration of the nanoscale poly(l-γ-glutamylglutamine)-paclitaxel conjugate (PGG-PTX) was still limited due to dysfunctional tumor blood vessels as well as high interstitial pressure in the tumor microenvironment. PURPOSE: The objective of the present research was to investigate the feasibility of co-administration of a tumor penetration enhancing peptide tLyp-1 for improving intratumoral accumulation and consequent anti-tumor efficacy of PGG-PTX. METHODS: The influence of co-administration of tLyP-1 with PGG-PTX on intratumoral accumulation (via HPLC-MS/MS) and anti-tumor efficacy (by monitoring the change in the tumor volume) was investigated using a breast cancer (4T1) tumor-bearing mouse model. In addition, the systemic toxicity of co-administration of tLyP-1 with PGG-PTX was assessed by monitoring the change in the animal body weight. RESULTS: It was observed that co-administration of tLyP-1 with PGG-PTX dramatically improved PGG-PTX accumulation in the tumors, resulting in improved inhibition efficiency against tumor growth. Moreover, co-administration of tLyP-1 with PGG-PTX did not change the systemic toxicity profile of PGG-PTX. CONCLUSION: Co-administration of tLyp-1 may be a promising strategy for improving the passive tumortargeting performance of polymeric drug conjugates.


Assuntos
Antineoplásicos Fitogênicos/administração & dosagem , Neoplasias da Mama/tratamento farmacológico , Paclitaxel/análogos & derivados , Peptídeos Cíclicos/química , Proteínas/administração & dosagem , Animais , Antineoplásicos Fitogênicos/farmacocinética , Antineoplásicos Fitogênicos/farmacologia , Linhagem Celular Tumoral , Cromatografia Líquida de Alta Pressão/métodos , Estudos de Viabilidade , Feminino , Camundongos , Camundongos Endogâmicos BALB C , Paclitaxel/administração & dosagem , Paclitaxel/farmacocinética , Paclitaxel/farmacologia , Peptídeos Cíclicos/administração & dosagem , Proteínas/farmacocinética , Proteínas/farmacologia , Espectrometria de Massas em Tandem/métodos , Carga Tumoral/efeitos dos fármacos , Microambiente Tumoral
17.
PLoS One ; 11(1): e0146659, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-26756336

RESUMO

BACKGROUND: Reports on antiretroviral therapy (ART) adherence are scare in China; we performed this meta-analysis to estimate ART adherence rates in different populations at high risk for HIV transmission in China. METHODS: We searched PubMed, Chinese Biomedical Literature Database (Chinese), China National Knowledge Infrastructure (Chinese), and Wanfang (Chinese) to identify studies published from January 1985 to May 2015. We used random-effects meta-analysis to calculate weighted mean estimates across studies and 95% CIs. Data were pooled with proportions transformed prior to pooling using the Freeman-Tukey double arcsine transformation and then back transformed to the original scale. We calculated the I2 (and its 95% confidence intervals) and tau2 to assess between-study heterogeneity. RESULTS: We identified 36 eligible articles, including 6885 HIV-positive individuals, reporting ART adherence. Pooled analysis produced an estimate of 77.61% (95% CI = 71.63-83.08) of patients with HIV with adequate adherence; however, high heterogeneity was observed between studies (I2 = 96.60%, 95%CI = 96.00%-97.20%; tau2 = 0.16). Three studies, which included 149 old HIV-infected patients, reported the highest ART adequate adherence rate (89.39%, 95% CI = 72.01-99.26) with high heterogeneity between the studies (I2 = 86.20%, 95%CI = 60.00-95.20%; tau2 = 0.13). While, only two studies, which included 143 heterosexual transmission group (HTG) patients, reported the lowest ART adequate adherence rate (51.55%, 95% CI = 41.33-61.71) with low heterogeneity between the studies (I2 = 31.3%, tau2 = 0.007). In the multivariable meta-regression model, high-risk populations was the main factor explaining heterogeneity (variance explained 28.14%). CONCLUSIONS: ART adherence in some high-risk populations (e.g., heterosexual transmission group) is below the recommended levels for maintaining virologic suppression. It is crucial to develop comprehensive intervention strategies to promote ART adherence in high-risk populations and effectively prevent the spread of HIV/AIDS in China.


Assuntos
Terapia Antirretroviral de Alta Atividade , Adesão à Medicação , China , Infecções por HIV/tratamento farmacológico , Humanos , Viés de Publicação , Análise de Regressão , Fatores de Risco
18.
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi ; 28(2): 120-124, 2016 Mar 09.
Artigo em Chinês | MEDLINE | ID: mdl-29469285

RESUMO

OBJECTIVE: To study the spatial and temporal characteristics of Oncomelania hupensis in Eryuan County, Yunnan Province from 2005 to 2012, so as to provide the scientific evidence for snail surveillance and control. METHODS: Based on the geographic database of O. hupensis snail distribution from 2005 to 2012, the spatial and local autocorrelation analysis and "hot spots" analysis were applied to analyze the spatial and temporal characteristics of the snails. RESULTS: Percent of frames with O. hupensis snails in Eryuan County decreased as a whole from 2005 to 2012. The spatial clustering of global autocorrelation (Moran's I) was increasing from 2007 to 2012 and all Moran's I values showed statistically significance. The local spatial autocorrelation analysis indicated that the number of villages of High-High type of correlation model increased from 2 in 2005 to 7 in 2012, which mainly clustered in plateau canyon areas. The infected snails with High-High type mainly distributed in plateau basin region in 2007. Further "hot spot" analysis found that the living snails gathered in Xinzhuang, Liantie, Xipo and Taiping nearby areas. CONCLUSIONS: The snail distribution in Eryuan has global and local spatial autocorrelations. The number of villages of High-High type of correlation increased. These findings provide the basis for target control of O.hupensis in the future.


Assuntos
Caramujos/fisiologia , Distribuição Animal , Animais , China , Reservatórios de Doenças/estatística & dados numéricos , Caramujos/crescimento & desenvolvimento , Análise Espaço-Temporal
19.
Zhongguo Zhong Yao Za Zhi ; 40(16): 3142-6, 2015 Aug.
Artigo em Chinês | MEDLINE | ID: mdl-26790282

RESUMO

The factors impacting the pregnancy rate and the live birth rate mainly include ovary function disorder and low endometrial receptivity, which can cause the difficulty in embryo implantation, early miscarriage and pregnancy failure. In recent years, researchers of the traditional Chinese medicine (TCM) have made active efforts in assisting IVF-ET, so as to achieve a great advance in improving the ovary reaction, treating the ovarian hyperstimulation syndrome (OHSS), improving the follicle, embryo quality and endometrial receptivity and protecting the fetus, which had been summarized in this article.


Assuntos
Medicamentos de Ervas Chinesas/administração & dosagem , Infertilidade Feminina/tratamento farmacológico , Transferência Embrionária , Feminino , Fertilização In Vitro/efeitos dos fármacos , Humanos , Infertilidade Feminina/terapia , Gravidez
20.
Chemistry ; 20(39): 12394-8, 2014 Sep 22.
Artigo em Inglês | MEDLINE | ID: mdl-25112517

RESUMO

A new ligand can be easily prepared, and its intramolecular dinuclear zinc complexes act as a high performance catalyst for the asymmetric alternating copolymerization of cyclohexene oxide and CO2 under very mild conditions (1 atm CO2 , room temperature), affording completely alternating polycarbonates with up to 93.8 % enantiomeric excess (ee) and 98 % yield. A high Mn value of 28 600 and a relatively narrow polydispersity (Mw /Mn ratio) of 1.43 were also achieved.

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