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Dalton Trans ; 48(16): 5144-5148, 2019 Apr 16.
Artigo em Inglês | MEDLINE | ID: mdl-30919864


A microporous metal-organic framework functionalized with in situ generated NHC-CuCl units (1) has been successfully synthesized from a novel imidazolium-containing ligand. In particular, the MOF 1 can catalyze ß-boration of α,ß-unsaturated carbonyl compounds, while the isoreticular version of 1 (1-im) modified with only imidazolium moiety cannot. This work demonstrates for the first time the heterogeneous catalysis of NHC-Cu(i)Cl within a MOF solid.

PLoS One ; 13(5): e0196668, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-29723230


BACKGROUND: China has a high rate of antibiotic use. The Chinese Ministry of Health (MOH) established the Center for Antibacterial Surveillance (CAS) to monitor the use of antibacterial agents in hospitals in 2005. The purpose of this study was to identify trends, pattern changes and regional differences in antibiotic consumption in 151 public general tertiary hospitals across China from 2011-2014. MATERIALS AND METHODS: Valid data for antibiotic use were collected quarterly, and the antibiotic consumption data were expressed as the defined daily dose (DDD) per 100 inpatient days (ID). We compared the patterns of antibiotic use in different classes and geographical clusters. RESULTS: Total antibiotic use significantly decreased (P = 0.018) from 75.86 DDD/100 ID in 2011 to 47.03 DDD/100 ID in 2014. The total consumption of flomoxef sodium and cefminox increased from 1.31 DDD/100 BD in 2011 to 8.6 DDD/100 BD in 2014. Cephalosporins were the most frequently used antibiotics in all regions. Third-generation cephalosporins accounted for more than 45% of the cephalosporins used. Carbapenem use substantially increased (P = 0.043). Penicillin combinations with inhibitors accounted for 50% of the penicillin used, and prescribed meropenem accounted for most of the carbapenems used in all regions in 2014. The subclasses in each antibiotic group were used differently between the seven regions, and the total hospital antibiotic use in 2014 differed significantly by region (P = 0.014). CONCLUSION: Although the volume and intensity of total antibiotic use decreased, the antibiotic use patterns were not optimal, and broad-spectrum antibiotics were still the main classes. The aggregate data obtained during the study period reveal similar antibiotic consumption patterns in different regions. These findings provide useful information for improving the rational use of antibiotics. More detailed data on antibiotics linked to inpatient diseases need to be collected in future studies.

Antibacterianos/uso terapêutico , Hospitais Gerais/estatística & dados numéricos , Hospitais Públicos/estatística & dados numéricos , Padrões de Prática Médica/estatística & dados numéricos , Centros de Atenção Terciária/estatística & dados numéricos , Antibacterianos/economia , Gestão de Antimicrobianos , China , Uso de Medicamentos/tendências , Humanos , Motivação , Padrões de Prática Médica/economia
Exp Ther Med ; 15(6): 4629-4636, 2018 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-29805479


The aim of the present study was to identify the effect of heme oxygenase (HO)-1 gene on cerebral ischemia-reperfusion injury. Sprague-Dawley rats were divided randomly into four groups: Sham group, vehicle group, empty adenovirus vector (Ad) group and recombinant HO-1 adenovirus (Ad-HO-1) transfection group. Rats in the vehicle, Ad and Ad-HO-1 groups were respectively injected with saline, Ad or Ad-HO-1 for 3 days prior to cerebral ischemia-reperfusion injury. Subsequently, the middle cerebral artery occlusion method was used to establish the model of cerebral ischemia-reperfusion injury. Following the assessment of neurological function, rats were sacrificed, and the infarction volume and apoptotic index in rat brains were measured. Furthermore, the protein expression levels of HO-1 in brain tissues were detected using western blot analysis. Results indicated that the neurological score of the Ad-HO-1 group was significantly increased compared with the Ad or vehicle groups, respectively (P<0.001). The volume of cerebral infarction and the index score of neuronal apoptosis in the vehicle and Ad groups was significantly increased compared with the Ad-HO-1 group (P<0.01). The death of neuronal cells following cerebral ischemia-reperfusion injury reduced remarkably induced by over-expression of HO-1. These findings suggest a neuroprotective role of HO-1 against brain injury induced by transient cerebral ischemia-reperfusion injury.

Phys Rev Lett ; 119(5): 056601, 2017 Aug 04.
Artigo em Inglês | MEDLINE | ID: mdl-28949739


We present a study of electric, thermal and thermoelectric response in noncollinear antiferromagnet Mn_{3}Sn, which hosts a large anomalous Hall effect (AHE). Berry curvature generates off-diagonal thermal (Righi-Leduc) and thermoelectric (Nernst) signals, which are detectable at room temperature and invertible with a small magnetic field. The thermal and electrical Hall conductivities respect the Wiedemann-Franz law, implying that the transverse currents induced by the Berry curvature are carried by Fermi surface quasiparticles. In contrast to conventional ferromagnets, the anomalous Lorenz number remains close to the Sommerfeld number over the whole temperature range of study, excluding any contribution by inelastic scattering and pointing to the Berry curvature as the unique source of AHE. The anomalous off-diagonal thermo-electric and Hall conductivities are strongly temperature dependent and their ratio is close to k_{B}/e.

Neurosci Lett ; 641: 8-14, 2017 02 22.
Artigo em Inglês | MEDLINE | ID: mdl-28115238


Both nerve growth factor (NGF) and heme oxygenases-1 (HO-1) promotes neuron survival from cerebral ischemic lesions. NGF protects neurons from oxygen-glucose deprivation (OGD), and HO-1 expression can be induced by some growth factors like NGF. This work attempted to identify the contribution of HO-1 on the neuroprotection role of NGF in OGD model, which is an injury simulation of ischemic neuron in vitro. The viability of cortical neurons cells treated with OGD restored significantly by pretreatment with NGF in a dose dependent manner. Moreover, NGF provided obvious protective effects against OGD-induced neurons apoptosis. It identified that NGF could prevent apoptosis and ROS (reactive oxygen species) accumulation in the primary cortical neurons exposed to OGD. NGF could up-regulate the expression level of HO-1, and then afford neuroprotection against OGD insult. In addition, we found that MEK/ERK pathway participated NGF-induced over-expression of HO-1, and was involved in the transcriptional activity or neuroprotection effect of NGF.

Apoptose , Glucose/deficiência , Heme Oxigenase-1/metabolismo , Fatores de Crescimento Neural/metabolismo , Neurônios/metabolismo , Estresse Oxidativo , Oxigênio/metabolismo , Animais , Hipóxia Celular , Sobrevivência Celular , Sistema de Sinalização das MAP Quinases , Fatores de Crescimento Neural/farmacologia , Neurônios/citologia , Neuroproteção , Cultura Primária de Células , Ratos Sprague-Dawley , Espécies Reativas de Oxigênio/metabolismo , Regulação para Cima