Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 17 de 17
Filtrar
Mais filtros










Base de dados
Intervalo de ano de publicação
1.
Environ Sci Technol ; 2020 Dec 08.
Artigo em Inglês | MEDLINE | ID: mdl-33290056

RESUMO

Nitrous acid (HONO) plays an important role in the budget of hydroxyl radical (•OH) in the atmosphere. Vehicular emissions are a crucial primary source of atmospheric HONO, yet remain poorly investigated, especially for diesel trucks. In this study, we developed a novel portable online vehicular HONO exhaust measurement system featuring an innovative dilution technique. Using this system coupled with a chassis dynamometer, we for the first time investigated the HONO emission characteristics of 17 light-duty diesel trucks (LDDTs) and 16 light-duty gasoline vehicles in China. Emissions of HONO from LDDTs were found to be significantly higher than previous studies and gasoline vehicles tested in this study. The HONO emission factors of LDDTs decrease significantly with stringent control standards: 1.85 ± 1.17, 0.59 ± 0.25, and 0.15 ± 0.14 g/kg for China III, China IV, and China V, respectively. In addition, we found poor correlations between HONO and NOx emissions, which indicate that using the ratio of HONO to NOx emissions to infer HONO emissions might lead to high uncertainty of HONO source budget in previous studies. Lastly, the HONO emissions are found to be influenced by driving conditions, highlighting the importance of conducting on-road measurements of HONO emissions under real-world driving conditions. More direct measurements of the HONO emissions are needed to improve the understanding of the HONO emissions from mobile and other primary sources.

2.
Front Oncol ; 10: 585288, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33194731

RESUMO

One common and reversible type of post-translational modification (PTM) is the addition of O-linked ß-N-acetylglucosamine (O-GlcNAc) modification (O-GlcNAcylation), and its dynamic balance is controlled by O-GlcNAc transferase (OGT) and glycoside hydrolase O-GlcNAcase (OGA) through the addition or removal of O-GlcNAc groups. A large amount of research data confirms that proteins regulated by O-GlcNAcylation play a pivotal role in cells. In particularly, imbalanced levels of OGT and O-GlcNAcylation have been found in various types of cancers. Recently, increasing evidence shows that imbalanced O-GlcNAcylation directly or indirectly impacts the process of cancer metastasis. This review summarizes the current understanding of the influence of O-GlcNAc-proteins on the regulation of cancer metastasis. It will provide a theoretical basis to further elucidate of the molecular mechanisms underlying cancer emergence and progression.

3.
Bioorg Med Chem Lett ; 30(21): 127504, 2020 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-32827631

RESUMO

25-OH ginsenosides are potent and rare prodrugs in natural sources. However current strategies for such modification always end up in undesirable side products and unsatisfied yield that hinders them from further applications. Herein, ginsenoside Rg1 was thoroughly converted into 20(S/R)-Rh1 and 25-OH-20(S/R)-Rh1 by Cordyceps Sinensis in an optimum medium. The chemical correctness of either 25-OH-20(S/R)-Rh1 epimers was validated by LC-IT-TOF-MSn and 13C NMR spectrometry. The biocatalytic pathway was established as Rg1 â†’ 20(S/R)-Rh1 â†’ 25-OH-20(S/R)-Rh1. The molar bioconversion rate for total 25-OH-20(S/R)-Rh1 was calculated to be 82.5%, of which S-configuration accounted for 43.2% while R-configuration 39.3%. These two 25-OH derivatives are direct hydration products from 20(S/R)-Rh1 without other side metabolites, suggesting this is a highly regioselective process. In conclusion, this biocatalytic system could be harnessed to facilitate the preparation of diversified 25-OH ginsenosides with high yields of the target compound and simple chemical background in the reaction mixture.

4.
Zhongguo Zhong Yao Za Zhi ; 45(13): 3233-3237, 2020 Jul.
Artigo em Chinês | MEDLINE | ID: mdl-32726034

RESUMO

This paper introduces the application and financing of programs of efficacy material base of traditional Chinese medicine funded by the National Natural Science Foundation of China(NSFC), the Youth Science Fund and the Regional Science Fund from 2016 to 2019, and conducts analysis and summary in terms of research objects and analysis methods, with the aim to provide reference for applicants for programs of efficacy material base of traditional Chinese medicine.


Assuntos
Administração Financeira , Disciplinas das Ciências Naturais , China , Fundações , Medicina Tradicional Chinesa
5.
J Food Sci Technol ; 57(6): 2283-2292, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-32431354

RESUMO

In this study, the saponin-rich fractions of five individual (two Red and three Black) sea cucumbers (Apostichopus japonicus) in South Korea were investigated for their antiproliferative effect against HL-60, B16F10, MCF-7, and Hep3B tumor cell lines. The red sea cucumber saponin-rich fraction (SSC) from Jeju Island (JRe) decreased the growth of HL-60 with an IC50 value of 23.55 ± 3.40 µg/mL, which represented the strongest anticancer activity among the extracts. Further, SSC downregulated B-cell lymphoma extra-large (Bcl-xL), while upregulating, to different degrees, Bcl-2-associated X protein (Bax), caspase-9, caspase-3, PARP cleavage, and apoptotic bodies in cancer cells. Evidence for SSC inducing apoptosis via the mitochondria-mediated pathway was found. The contents of SSCs were determined using ultra high-performance liquid chromatography coupled with a quadrupole orbitrap mass spectrometry to comparatively evaluate the regional influence. In West Sea, the total SSC content of A. japonicus was 15.5 mg/g, representing the highest content, while A. japonicus in the South Sea yielded the lowest content at 8 mg/g. The major saponin constituent in SSC was identified as Holotoxin A1, which may the anti-tumor compound in A. japonicus.

6.
Int J Biol Macromol ; 2020 May 10.
Artigo em Inglês | MEDLINE | ID: mdl-32437814

RESUMO

Panax ginseng glycoproteins (PGG) has been shown biological activity, but researches in this field are rarely reported. In this paper, PGG were prepared by reflux and then purified with macroporous resin column. Further separation and purification of PGG using high performance liquid chromatography (HPLC) and two major components (PGG-1, PGG-2) were obtained. The molecular weights were calculated by gel permeation chromatography (GPC), and the results are 1.5 KDa and 8.2 KDa respectively. The MTT assay was used to study the cytoprotective effects of PGG, the results exhibited that PGG had significant effect (P < 0.01), and showed an obvious dose-effect relationship. Anti-apoptosis experiment results showed that PGG and PGG-2 can inhibit Aß-induced apoptosis in SH-SY5Y cells (P < 0.05), and PGG-2 displayed better activity. The structures of N- and O-glycan were determined by combination of LC-MS/MS and methylation analysis. The computed parameters of PGG determined by MS including the theoretical isoelectric point (pI), instability index, aliphatic index and grand average of hydropathicity (GRAVY) were summarized systematically. The distinct differences between two parts would affect the behavior of PGG in vivo. The results of activity test and bioinformatics analysis would guide the study of PGG in pharmacokinetics and mechanism.

7.
Int J Biol Macromol ; 150: 695-704, 2020 May 01.
Artigo em Inglês | MEDLINE | ID: mdl-32061699

RESUMO

Protein from Panax ginseng can improve learning, memory, and analgesia. Here, we investigated a fluorescence labeling method that can be used to determine the in vivo distribution of P. ginseng protein (PGP). High-performance liquid chromatography (HPLC) was used to define the amino acid composition and molecular weight of PGP; LC-MS/MS was used to identify the PGP structure, which was fluorescently-labeled using a fluorescein isothiocyanate (FITC) probe. The connection form of the PGP fluorescent marker (PGP-FITC) was identified by ultraviolet and infrared spectrophotometry. The in vivo distribution of PGP was observed by fluorescence imaging, and tissue content was determined. Results showed that PGP was enriched in the brain and that vascular epithelial cells showed specific uptake. We provide an experimental method to label and identify the in vivo distribution of PGP, which forms the basis for future studies to determine whether PGP can penetrate the blood-brain barrier (BBB) and elucidate the transport mechanism.

8.
Nanomaterials (Basel) ; 9(10)2019 Oct 16.
Artigo em Inglês | MEDLINE | ID: mdl-31623247

RESUMO

Nanophononic materials have recently arisen as a promising way for controlling heat transport, mirroring the results in macroscopic phononic materials for sound transmission, filtering and attenuation applications. Here we present a Finite Element numerical simulation of the transient propagation of an acoustic Wave-Packet in a 2D nanophononic material, which allows to identify the effect of the nanostructuration on the acoustic attenuation length and thus on the transport regime for the vibrational energy. Assuming elastic behavior in the matrix and in the inclusions, we find that the rigidity contrast between them not only tunes the apparent attenuation length of the wave packet along its main trajectory, but gives rise to different behaviours, from weak to strong scattering, and waves pinning. As a consequence, different energy transport regimes can be identified in the three-parameter space of the excitation frequency, inclusions size and rigidity contrast, leading to the identification of a combination of parameters allowing for the shortest attenuation distance. These results could have applications both in the field of acoustic insulation, and for the control of heat transfer.

9.
Clin Rehabil ; 33(9): 1479-1491, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31081365

RESUMO

OBJECTIVE: The aim of this study was to validate a novel pictorial-based Longshi Scale for evaluating a patient's disability by healthcare professionals and non-professionals. DESIGN: Prospective study. SETTING: Rehabilitation departments from a grade A, class 3 public hospital, a grade B, class 2 public hospital, and a private hospital and seven community rehabilitation centers. SUBJECTS: A total of 618 patients and 251 patients with functional disabilities were recruited in a two-phase study, respectively. MAIN MEASURES: Outcome measure: pictorial scale of activities of daily living (ADLs, Longshi Scale). Reference measure: Barthel Index. The Spearman correlation coefficient was used to analyze the validity of Longshi Scale against Barthel Index. RESULTS: In phase 1 study, from March 2016 to August 2016, the results demonstrated that the Longshi Scale was both reliable and valid (intraclass correlation coefficient based on two-way random effect (ICC2,1) = 0.877-0.974 for intra-rater reliability; ICC2,1 = 0.928-0.979; κ = 0.679-1.000 for inter-rater reliability; intraclass correlation coefficient based on one-way random effect (ICC1,1) = 0.921-0.984 for test-retest reliability and Spearman correlation coefficient = 0.836-0.899). In the second phase, in March 2018, results further demonstrated that the Longshi Scale had good inter-rater and intra-rater reliability among healthcare professionals and non-professionals including therapists, interns, and personal care aids (ICC1,1 = 0.822-0.882 on Day 1; ICC1,1 = 0.842-0.899 on Day 7 for inter-rater reliability). In addition, the Longshi Scale decreased assessment time significantly, compared with the Barthel Index assessment (P < 0.01). CONCLUSION: The Longshi Scale could potentially provide an efficient way for healthcare professionals and non-professionals who may have minimal training to assess the ADLs of functionally disabled patients.


Assuntos
Avaliação da Deficiência , China , Feminino , Pessoal de Saúde , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Psicometria , Reprodutibilidade dos Testes
10.
Biomed Res Int ; 2019: 2561828, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30941359

RESUMO

The changes of brain metabolism in mice after injection of ginseng glycoproteins (GPr) were analyzed by gas chromatography mass spectrometry- (GC/MS-) based metabolomics platform. The relationship between sedative and hypnotic effects of ginseng glycoproteins and brain metabolism was discussed. Referring to pentobarbital sodium subthreshold test, we randomly divided 20 mice into two groups: control and ginseng glycoproteins group. The mice from the control group were treated with normal saline by i.p and GPr group were treated with 60 mg/kg of GPr by i.p. The results indicated that GPr could significantly improve the sleep quality of mice. Through multivariate statistical analysis, we found that there were 23 differential metabolites in whole brain tissues between the control group and the GPr group. The pathway analysis exhibited that GPr may be involved in the regulation of the pathway including purine metabolism, nicotinate and nicotinamide metabolism, glycine, serine and threonine metabolism, arginine and proline metabolism, alanine, aspartate and glutamate metabolism, and steroid hormone biosynthesis. This work is helpful to understand the biochemical mechanism of GPr on promoting sleep and lay a foundation for further development of drugs for insomnia.


Assuntos
Glicoproteínas/farmacologia , Metabolômica/métodos , Panax/química , Sono/efeitos dos fármacos , Animais , Análise Discriminante , Cromatografia Gasosa-Espectrometria de Massas , Análise dos Mínimos Quadrados , Masculino , Metaboloma , Camundongos , Pentobarbital/farmacologia , Análise de Componente Principal , Extratos de Tecidos/química
11.
Front Pharmacol ; 10: 9, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30837865

RESUMO

Coptis, a traditional medicinal plant, has been used widely in the field of traditional Chinese medicine for many years. More recently, the chemical composition and bioactivity of Coptis have been studied worldwide. Berberine is a main component of Rhizoma Coptidis. Modern medicine has confirmed that berberine has pharmacological activities, such as anti-inflammatory, analgesic, antimicrobial, hypolipidemic, and blood pressure-lowering effects. Importantly, the active ingredient of berberine has clear inhibitory effects on various cancers, including colorectal cancer, lung cancer, ovarian cancer, prostate cancer, liver cancer, and cervical cancer. Cancer, ranked as one of the world's five major incurable diseases by WHO, is a serious threat to the quality of human life. Here, we try to outline how berberine exerts antitumor effects through the regulation of different molecular pathways. In addition, the berberine-mediated regulation of epigenetic mechanisms that may be associated with the prevention of malignant tumors is described. Thus, this review provides a theoretical basis for the biological functions of berberine and its further use in the clinical treatment of cancer.

12.
Molecules ; 23(6)2018 May 31.
Artigo em Inglês | MEDLINE | ID: mdl-29857514

RESUMO

Panax ginseng is well known for its medicinal functions. As a class of important compound of ginseng, ginsenoside is widely studied around the world. In addition, ginseng glycopeptides also showed good biological activity, but researches in this field are rarely reported. In this study, ginseng glycopeptides (Gg) were first prepared from Panax ginseng by reflux extracted with 85% ethanol and the following purification with Sephadex G-15 column. Then, the inflammatory pain models induced by carrageenan and the rat pain models induced by Faure Marin were established for research on mechanism of analgesic activities. It is showed that Gg had an obvious inhibiting effect on inflammation and a significant reduction on the Malondialdehyde (MDA) of inflammatory foot tissue. And there were significant differences between moderate to high dose of Gg and model group in Interleukin 1ß (IL-1ß), Interleukin 2 (IL-2), Interleukin 4 (IL-4), Tumor necrosis factor α (TNF-α) and Histamine. The two models can be preliminarily determined that the analgesic effect of Gg may be peripheral, which mechanism may be related to the dynamic balance between proinflammatory cytokines (TNF-α, IL-1ß) and anti-inflammatory cytokines (IL-2, IL-4, and Interleukin 10 (IL-10)). A series of methods were used to study Gg in physical-chemical properties and linking mode of glycoside. The high-resolution mass spectrometry was used for identification of the structure of Gg. Moreover, the structure of 20 major Gg were investigated and identified. The structural analysis of Gg was benefit for the next study on structure-activity relationship.


Assuntos
Analgésicos/química , Analgésicos/farmacologia , Anti-Inflamatórios/química , Anti-Inflamatórios/farmacologia , Glicopeptídeos/química , Glicopeptídeos/farmacologia , Panax/química , Animais , Carragenina/química , Carragenina/farmacologia , Citocinas/metabolismo , Modelos Animais de Doenças , Mediadores da Inflamação/metabolismo , Masculino , Metilação , Estrutura Molecular , Dor/etiologia , Manejo da Dor , Ratos , Relação Estrutura-Atividade , Espectrometria de Massas em Tandem
13.
J Pharm Pharmacol ; 70(8): 1048-1058, 2018 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-29770446

RESUMO

OBJECTIVES: To investigate the antitumour property of tetrandrine by inducing autophagy and apoptosis in human gastric cancer cells, and to explore the potential molecular mechanisms. METHODS: The antitumour activity of tetrandrine was assessed through MTT assay. Apoptosis was measured by flow cytometry and microscopic examination of cellular morphology. The mitochondrial membrane potential was detected by staining with Rh-123. Induction of autophagy was monitored by transmission electron microscopy observation, using GFP-LC3 transfection. KEY FINDINGS: The results revealed that tetrandrine exhibits significant antitumour activity against gastric human cancer cell and the antigastric tumour activity was depended on inducing autophagy and apoptosis through upregulating the apoptosis-related protein (cleaved PARP, cleaved caspase-3 and cleaved caspase-9) and autophagy-related protein (Beclin-1, LC3-II and p62), and decreasing the phosphorylation of AKT/mTOR, PS6K and P-4EBP1. Adding the inhibitor of autophagy, 3-MA or Baf-A1, increased the viability of tetrandrine-exposed gastric cancer cells, which confirmed the role of autophagy played in the gastric cancer cell death induced by tetrandrine. CONCLUSIONS: These results demonstrated that the antitumour effects of tetrandrine by inducing autophagy and apoptosis involving Akt/mTOR pathway. Thus, tetrandrine may be a promising lead compound to be further developed in future for cancer therapy.


Assuntos
Antineoplásicos Fitogênicos/farmacologia , Apoptose/efeitos dos fármacos , Autofagia/efeitos dos fármacos , Benzilisoquinolinas/farmacologia , Proliferação de Células/efeitos dos fármacos , Neoplasias Gástricas/patologia , Antineoplásicos Fitogênicos/isolamento & purificação , Benzilisoquinolinas/isolamento & purificação , Técnicas de Cultura de Células , Linhagem Celular Tumoral , Sobrevivência Celular/efeitos dos fármacos , Relação Dose-Resposta a Droga , Humanos , Estrutura Molecular , Proteínas Proto-Oncogênicas c-akt/metabolismo , Stephania tetrandra/química , Serina-Treonina Quinases TOR/metabolismo
14.
Int J Biol Macromol ; 113: 607-615, 2018 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-29408615

RESUMO

The root of Panax ginseng C. A. Mey (Araliaceae) has medicinal value in complex system of Traditional Chinese medicines for its use in improving cognitive function. A glycoproteins named PGL-1 was extracted from ginseng which subjected to through a macroporous resin, hollow-fiber ultrafiltration and dialyzed. The glycoproteins has a molecular weight in the range from 0.4 to 4.4kDa, with an average molecular mass of 1.6kDa. HPLC analysis revealed that the compositions of glycoproteins included fucose, mannose, rhamnose, glucose, galacturonic acid, N-acetylglucosamine and N-acetylgalactosamine. Glycan of PGL-1 has a backbone of →4)-Rha-(1→, →4)-Fuc -(1→, →6)-Gal-(1→, →4)-GalA-(1→, →4)-GlcNAc-(1→ and →4)-GalNAc-(1→,and (→3,6)-Man-(1→) was distributed in branches. The (1→)-Fuc, (1→)-Glc and (1→)-GlcNAc or (1→)-GalNAc were regarded as a terminal residue. The Morris water maze test revealed that the PGL-1 can effectively alleviate the memory impairment symptoms of rats induced by Aß25-35. All dose groups showed significant activity of protective effect on apoptosis SH-SY5Y induced by Aß25-35, and obviously inhibited the S phase arrest. Compared with Aß25-35 treatment alone, a significant reduction in NO concentration and NOS activity was detected in cells co-administered with glycoproteins. Thus, glycoproteins derived from ginseng might be a promising anti-AD reagent.


Assuntos
Glicoproteínas/farmacologia , Fármacos Neuroprotetores/farmacologia , Panax/química , Peptídeos beta-Amiloides/química , Peptídeos beta-Amiloides/toxicidade , Animais , Apoptose/efeitos dos fármacos , Apoptose/efeitos da radiação , Ciclo Celular/efeitos dos fármacos , Ciclo Celular/efeitos da radiação , Linhagem Celular Tumoral , Sobrevivência Celular/efeitos dos fármacos , Sobrevivência Celular/efeitos da radiação , Feminino , Humanos , Masculino , Memória/efeitos dos fármacos , Memória/efeitos da radiação , Óxido Nítrico/metabolismo , Óxido Nítrico Sintase/metabolismo , Fragmentos de Peptídeos/química , Fragmentos de Peptídeos/toxicidade , Agregados Proteicos , Ratos , Ratos Wistar
15.
J Ethnopharmacol ; 148(3): 946-50, 2013 Jul 30.
Artigo em Inglês | MEDLINE | ID: mdl-23747537

RESUMO

ETHNOPHARMACOLOGICAL RELEVANCE: The root of Panax ginseng C.A. Mey has various beneficial pharmacological effects. The present study aimed to evaluate the analgesic activities of glycoproteins from the root of Panax ginseng C.A. Mey in mice. MATERIALS AND METHODS: Glycoproteins were isolated and purified from the root of Panax ginseng C.A. Mey. Physicochemical properties and molecular mass were determined by chemical assay and HPLC. Acetic acid-induced writhing and hot-plate tests were employed to study the analgesic effect of glycoproteins and compared with that of aspirin or morphine. The locomotor activity was tested in mice by using actophometer. RESULTS: Four glycoproteins were obtained. The glycoproteins which protein content was the highest (73.04%) displayed dose-dependent analgesic effect. In writhing test, the glycoproteins significantly inhibited writhes (P<0.001) at the dose of 20 mg/kg by intraperitoneal injection. In hot-plate test, only at the dose of 20 mg/kg prolong the hot-plate latency (P<0.05, at 30 min). In the locomotor activity test, the glycoproteins were significant decrease of motility counts at the dose of 20 and 40 mg/kg. CONCLUSION: These findings collectively indicate that the glycoproteins from the root of Panax ginseng C.A. Mey exhibited significant analgesic activities and the proteins were the active site, providing evidence for its pharmacal use.


Assuntos
Analgésicos/uso terapêutico , Glicoproteínas/uso terapêutico , Dor/tratamento farmacológico , Panax , Ácido Acético , Analgésicos/isolamento & purificação , Analgésicos/farmacologia , Animais , Feminino , Glicoproteínas/isolamento & purificação , Glicoproteínas/farmacologia , Temperatura Alta , Masculino , Camundongos , Morfina/farmacologia , Atividade Motora/efeitos dos fármacos , Dor/induzido quimicamente , Dor/fisiopatologia , Fitoterapia , Extratos Vegetais/química , Raízes de Plantas
16.
Molecules ; 17(4): 3609-17, 2012 Mar 23.
Artigo em Inglês | MEDLINE | ID: mdl-22447024

RESUMO

The body of tremella were decocted with water, and hydrolyzed with 0.1 mol/L hydrochloric acid for different times, giving tremella polysaccharides with six molecular mass values. The structures of all the tremella polysaccharides had non-reducing terminals of ß-D-pyranglucuronide, the backbone was composed of (1 → 3)-linked ß-D-manno-pyranoside, and the side chain composed of (1 → 6)-linked ß-D-xylopyranoside was attached to the C(2) of the backbone mannopyranoside. Immunomodulatory effect studies indicated that tremella polysaccharides increased the counts of leukocytes in the peripheral blood which were significantly lowered by cyclophosphamide, and the lower the molecular mass of the tremella polysaccharide, the better this effect was.


Assuntos
Antineoplásicos Alquilantes/toxicidade , Basidiomycota/química , Ciclofosfamida/toxicidade , Leucopenia/induzido quimicamente , Polissacarídeos/química , Animais , Células da Medula Óssea/efeitos dos fármacos , Feminino , Contagem de Leucócitos , Leucócitos/efeitos dos fármacos , Leucopenia/tratamento farmacológico , Masculino , Metilação , Peso Molecular , Polissacarídeos/administração & dosagem , Polissacarídeos/farmacologia , Ratos
17.
Yao Xue Xue Bao ; 45(7): 813-20, 2010 Jul.
Artigo em Chinês | MEDLINE | ID: mdl-20931776

RESUMO

Heat shock protein 90 is a new target of antitumor drug, the inhibitor of Hsp90 fight against tumor by destroy and degrade the structure of protein. In recent years, looking for Hsp90 inhibitor is not only via structure modifying of natural products, but also via high throughput screening and computer aided drug design to find and synthesize new kinds of Hsp90 inhibitor. Anyway, Hsp90 inhibitor has considered as an important biology target and to pay more and more attention. This review describes recent developments of small molecule Hsp90 inhibitors.


Assuntos
Antineoplásicos/química , Proteínas de Choque Térmico HSP90/antagonistas & inibidores , Adenina/análogos & derivados , Adenina/química , Adenina/farmacologia , Animais , Anisóis/química , Anisóis/farmacologia , Antineoplásicos/farmacologia , Antineoplásicos/uso terapêutico , Benzoquinonas/química , Benzoquinonas/uso terapêutico , Catequina/análogos & derivados , Catequina/química , Catequina/farmacologia , Linhagem Celular Tumoral , Cristalização , Proteínas de Choque Térmico HSP90/química , Compostos Heterocíclicos com 2 Anéis/química , Compostos Heterocíclicos com 2 Anéis/farmacologia , Humanos , Lactamas Macrocíclicas/química , Lactamas Macrocíclicas/uso terapêutico , Macrolídeos/química , Macrolídeos/farmacologia , Estrutura Molecular , Neoplasias/tratamento farmacológico , Neoplasias/patologia , Pirazóis/química , Pirazóis/farmacologia , Relação Estrutura-Atividade
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA