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1.
Food Sci. Technol (SBCTA, Impr.) ; 38(1): 13-18, Jan.-Mar. 2018. tab, graf
Artigo em Inglês | LILACS-Express | ID: biblio-892236

RESUMO

Abstract In the present study, the software Aspen Plus® was used to analyse two different systems for CO2 recycle in a SFE process for extraction of more polar compounds using ethanol as co-solvent, the most common co-solvent used due to its environment-friendly nature. The extraction process of β-ecdysone from Brazilian ginseng roots was considered as example in the computational simulations. The first CO2 recycle system, named Recycle A, considered the compression of the CO2 separated in the second flash to the recycle pressure assumed at the first flash tank, its cooling to 25 °C and recirculation, while the second recycle system, named Recycle B, considered the cooling and pumping of the CO2 separated in the second flash, its heating to 25 °C and recirculation. The best techno-economic condition to operate the recycling step would be using Recycle A at 40 bar and 30 °C considering a stand-alone SFE process; and using Recycle B at 40 bar and 40 °C, considering this process in close proximity of a hypothetical sugarcane biorefinery. Therefore, these results suggest that the selection where would be located the SFE plant should be taken into account during the first steps of the process design.

2.
Parasitol Int ; 56(2): 135-9, 2007 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-17306614

RESUMO

The branches and leaves of Tabernaemontana catharinensis were extracted with supercritical fluid using a mixture of CO(2) plus ethanol (SFE), and the indole alkaloid enriched fraction (AF3) was selected for anti-Leishmania activity studies. We found that AF3 exhibits a potent effect against intracellular amastigotes of Leishmania amazonensis, a causative agent of New World cutaneous leishmaniasis. AF3 inhibits Leishmania survival in a dose-dependent manner, and reached 88% inhibition of amastigote growth at 100 microg/mL. The anti-parasite effect was independent of nitric oxide (NO), since AF3 was able to inhibit NO production induced by IFN-gamma plus LPS. In addition, AF3 inhibited TGF-beta production, which could have facilitated AF3-mediated parasite killing. The AF3 fraction obtained from SFE was nontoxic for host macrophages, as assessed by plasma membrane integrity and mitochondrial activity. We conclude that SFE is an efficient method for obtaining bioactive indole alkaloids from plant extracts. Importantly, this method preserved the alkaloid properties associated with inhibition of Leishmania growth in macrophages without toxicity to host cells.


Assuntos
Alcaloides/farmacologia , Leishmania/efeitos dos fármacos , Macrófagos Peritoneais/parasitologia , Extratos Vegetais/farmacologia , Tabernaemontana/química , Alcaloides/isolamento & purificação , Animais , Dióxido de Carbono/química , Células Cultivadas , Etanol/química , Leishmania/crescimento & desenvolvimento , Camundongos , Testes de Sensibilidade Parasitária , Extratos Vegetais/isolamento & purificação
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