Your browser doesn't support javascript.
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 24
Filtrar
Mais filtros










Tipo de estudo
Intervalo de ano de publicação
1.
J Clin Med ; 8(9)2019 Sep 04.
Artigo em Inglês | MEDLINE | ID: mdl-31487953

RESUMO

Type 2 diabetes (T2D) is a metabolic disorder characterized by hyperglycemia and insulin resistance in which oxidative stress is thought to be a primary cause. Considering that mitochondria are the main source of ROS, we have set out to provide a general overview on how oxidative stress is generated and related to T2D. Enhanced generation of reactive oxygen species (ROS) and oxidative stress occurs in mitochondria as a consequence of an overload of glucose and oxidative phosphorylation. Endoplasmic reticulum (ER) stress plays an important role in oxidative stress, as it is also a source of ROS. The tight interconnection between both organelles through mitochondrial-associated membranes (MAMs) means that the ROS generated in mitochondria promote ER stress. Therefore, a state of stress and mitochondrial dysfunction are consequences of this vicious cycle. The implication of mitochondria in insulin release and the exposure of pancreatic ß-cells to hyperglycemia make them especially susceptible to oxidative stress and mitochondrial dysfunction. In fact, crosstalk between both mechanisms is related with alterations in glucose homeostasis and can lead to the diabetes-associated insulin-resistance status. In the present review, we discuss the current knowledge of the relationship between oxidative stress, mitochondria, ER stress, inflammation, and lipotoxicity in T2D.

2.
Rev. argent. cardiol ; 86(6): 20-26, dic. 2018. graf
Artigo em Espanhol | LILACS-Express | ID: biblio-1003233

RESUMO

RESUMEN Introducción: La fracción de eyección es un parámetro débil para evaluar la función ventricular en la hipertrofia ventricular. Es de fundamental importancia analizar aspectos de la mecánica ventricular que podrían diferenciar una amiloidosis cardiaca de una miocardiopatía hipertrófica. Objetivo: Comparar el comportamiento del strain longitudinal y otros parámetros de la mecánica ventricular entre pacientes con miocardiopatía hipertrófica y amiloidosis cardíaca ambos con fracción de eyección conservada. Material y métodos: Estudio comparativo, prospectivo realizado en 15 pacientes con amiloidosis cardíaca (Grupo G 1) y 15 pacientes con miocardiopatía hipertrófica (G 2), ambos con fracción de eyección conservada (> 50%). Fueron analizados con ecocardiografía por seguimiento de marcas (speckle tracking), parámetros de strain y rotacionales del VI. El strain longitudinal se obtuvo a partir de planos apicales de 4, 3 y 2 cámaras. El strain circunferencial y la rotación ventricular a partir de planos transversales del VI. Se calculó el giro: suma de rotación apical y basal (°), torsión (giro / distancia base-ápex del VI (°/cm)) y los nuevos parámetros: producto de deformación (multiplicación entre el strain longitudinal global y el strain circunferencial apical); índice de deformación (°/%): (giro / strain longitudinal) y el cociente fracción de eyección / strain longitudinal global Resultados: Los pacientes con amiloidosis cardíaca presentaron valores significativamente menores de fracción de eyección (58,08% ± 6,16 vs. 67,15% ± 8,09; p = 0,012) y de strain longitudinal global (-12,61% ± 4,32 vs. -17,15% ± 3,95; p = 0,008) a expensas de los segmentos basales. No se constataron diferencias significativas con el giro, la torsión, el strain circunferencial y el radial. El producto entre strain longitudinal y el circunferencial apical resultó disminuido mientras que el cociente fracción de eyección / strain longitudinal global se encontró aumentado de manera significativa en los pacientes con amiloidosis. Conclusiones: El producto strain longitudinal x strain circunferencial apical y el cociente fracción de eyección / strain longitudinal global son parámetros útiles que permiten diferenciar pacientes con amiloidosis cardíaca de pacientes con miocardiopatía hipertrófica.


ABSTRACT Background: Ejection fraction is a poor parameter to assess left ventricular function in ventricular hypertrophy. It is highly important to analyze aspectis of ventricular mechanics that could differentiate cardiac amyloidosis from hypertrophic car-diomyopathy. Objective: The aim of this study was to compare longitudinal strain and other ventricular mechanical parameters between patientis with hypertrophic cardiomyopathy and cardiac amyloidosis, both with preserved ejection fraction. Methods: A comparative, prospective study was conducted in 15 patientis with cardiac amyloidosis Group (G) 1 and 15 pa-tientis with hypertrophic cardiomyopathy (G2), both presenting preserved ejection fraction (>50%). Patientis were analyzed with speckle tracking echocardiography and strain and left ventricular (LV) rotational parameters. Longitudinal strain was obtained from apical 4-, 3- and 2-chamber planes. Circumferential strain and ventricular rotation were obtained from LV transverse planes. Twist: algebraic sum of apical and basal rotation (°), torsion [twist/LV base-apex distance (º/cm)] and the new parameters: deformation product (global longitudinal strain × apical circumferential strain); deformation index: twist/ longitudinal strain (°/%) and ejection fraction/global longitudinal strain ratio were calculated. Resultis: Patientis with cardiac amyloidosis presented significantly lower ejection fraction (58.08%±6.16 vs. 67.15%±8.09; p=0.012) and global longitudinal strain values (-12.61%±4.32 vs. -17.15%±3.95; p=0.008) at the expense of basal segmentis. No significant differences were found for twist, torsion, and circumferential and radial strain. The product between longitudinal strain and apical circumferential strain decreased, while the ejection fraction/global longitudinal strain ratio was significantly increased in patientis with cardiac amyloidosis. Conclusions: The product of longitudinal strain × apical circumferential strain and the ejection fraction/global longitudinal strain ratio are useful parameters that allow differentiating cardiac amyloidosis from hypertrophic cardiomyopathy patientis.

3.
Cardiovasc Ultrasound ; 16(1): 16, 2018 Sep 18.
Artigo em Inglês | MEDLINE | ID: mdl-30223828

RESUMO

BACKGROUND: Left ventricular ejection fraction (LVEF) results from the combined action of longitudinal and circumferential contraction, radial thickening, and basal and apical rotation. The study of these parameters together may lead to an accurate assessment of the cardiac function. METHODS: Ninety healthy volunteers, categorized by gender and age (≤ 55 and >  55 years), were evaluated using two-dimensional speckle tracking echocardiography. Transversal views of the left ventricle (LV) were obtained to calculate circumferential strain and left ventricular twist, while three apical views were obtained to determine longitudinal strain (LS) and mitral annular plane systolic excursion (MAPSE). We established the integral myocardial function of the LV according to: 1. The Combined Deformation Parameter (CDP), which includes Deformation Product (DP) - Twist x LS (° x %) - and Deformation Index (DefI) -Twist / LS (° / %)-; and 2. the Torsion Index (TorI): Twist / MAPSE (° / cm). RESULTS: The mean age of our patients was 50.3 ± 11.1 years. CDP did not vary with gender or age. The average DP was - 432 ± 172 ° x %, and the average DefI was - 0.96 ± 0.36 ° / %. DP provides information about myocardial function (normal, pseudonormal, depressed), and the DefI quotient indicates which component (s) is/are affected in cases of abnormality. TorI was higher in volunteers over 55 years (16.5 ± 15.2 vs 13.1 ± 5.0 °/cm, p = 0.003), but did not vary with gender. CONCLUSIONS: The proposed parameters integrate values of twisting and longitudinal shortening. They allow a complete physiological assessment of cardiac systolic function, and could be used for the early detection and characterization of its alteration.


Assuntos
Ecocardiografia/métodos , Ventrículos do Coração/diagnóstico por imagem , Volume Sistólico/fisiologia , Função Ventricular Esquerda/fisiologia , Feminino , Voluntários Saudáveis , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Sístole
4.
J Cardiovasc Dev Dis ; 5(3)2018 Aug 09.
Artigo em Inglês | MEDLINE | ID: mdl-30096870

RESUMO

BACKGROUND: According to the ventricular myocardial band model, the diastolic isovolumetric period is a contraction phenomenon. Our objective was to employ speckle-tracking echocardiography (STE) to analyze myocardial deformation of the left ventricle (LV) and to confirm if it supports the myocardial band model. METHODS: This was a prospective observational study in which 90 healthy volunteers were recruited. We evaluated different types of postsystolic shortening (PSS) from an LV longitudinal strain study. Duration of latest deformation (LD) was calculated as the time from the start of the QRS complex of the ECG to the latest longitudinal deformation peak in the 18 segments of the LV. RESULTS: The mean age of our subjects was 50.3 ± 11.1 years. PSS was observed in 48.4% of the 1620 LV segments studied (19.8%, 13.5%, and 15.1% in the basal, medial, and apical regions, respectively). PSS was more frequent in the basal, medial septal, and apical anteroseptal segments (>50%). LD peaked in the interventricular septum and in the basal segments of the LV. CONCLUSIONS: The pattern of PSS and LD revealed by STE suggests there is contraction in the postsystolic phase of the cardiac cycle. The anatomical location of the segments in which this contraction is most frequently observed corresponds to the main path of the ascending component of the myocardial band. This contraction can be attributed to the protodiastolic untwisting of the LV.

5.
Rev. Eugenio Espejo ; 11(1): 57-63, Jun.-2017.
Artigo em Espanhol | LILACS | ID: biblio-980843

RESUMO

La esclerosis lateral amiotrófica es una enfermedad del sistema nervioso central. Se presenta el caso de un paciente masculino, raza blanca, de 50 años; el que acude a consulta en el Hos-pital Provincial General Docente "Mártires del 9 de abril" por presentar debilidad de los miembros inferiores. El examen físico mostró fasciculaciones musculares diseminadas, debi-lidad muscular próximo-distal (-2) en los cuatro miembros, atrofia muscular que afecta mus-culatura distal y proximal de las extremidades, sialorrea, lenguaje disártrico, reflejos osteo-tendinosos exaltados de forma generalizada y Babinski bilateral. Los exámenes complemen-tarios arrojaron patrón neurógeno dependiente de los miotomas de C6-C8 con signos de denervación. Diagnóstico nosológico: esclerosis lateral amiotrófica. El enfermo refiere histo-rial de esa patología por 14 años, lo que solo se observa en aproximadamente el 10% de los casos


Amyotrophic lateral sclerosis is a disease of the central nervous system. The clinical case of a male patient, white race and 50 years old is presented. This one goes to consultation in the Provincial General Hospital "Mártires del 9 de April" for presenting weakness in lower limbs. The physical examination showed disseminated muscle twitching, proximal-distal muscular weakness (-2) in all four limbs, muscular atrophy affecting the distal and proximal muscles of the extremities, sialorrhea, disartic language, generalized extenuated osteotendi-nous reflexes and bilateral Babinski. The complementary tests showed a neurogenic pattern dependent on the C6-C8 myotomes with signs of denervation. Nosological diagnosis: amyo-trophic lateral sclerosis. The patient refers history of that pathology.


Assuntos
Humanos , Masculino , Pessoa de Meia-Idade , Quadriplegia , Sialorreia , Atrofia Muscular , Esclerose Amiotrófica Lateral , Imagem por Ressonância Magnética , Eletromiografia
6.
Rev. cuba. med ; 52(3)jul.-sept.. 2013. tab
Artigo em Espanhol | CUMED | ID: cum-57849

RESUMO

Se realizó un estudio descriptivo transversal para describir el comportamiento de la pielonefritis aguda recurrente en mujeres de 18 y más años de edad, que ingresaron en el Hospital Mártires del 9 de Abril de Sagua la Grande, de enero de 2004 a junio de 2007. El universo estuvo constituido por las 593 pacientes ingresadas con ese diagnóstico. Se realizó un muestreo no probabilístico por criterios y la muestra quedó constituida por 67 pacientes. Las edades fluctuaron entre 18 y 85 años. Las manifestaciones clínicas más comunes fueron: dolor lumbar, fiebre y síntomas urinarios bajos. En el examen físico se halló dolor a la palpación profunda de las fosas lumbares, prácticamente, en todos los casos. El diagnóstico de certeza se realizó por el urocultivo, en 104 ocasiones. Los gérmenes que con mayor frecuencia infectaron las vías urinarias altas fueron bacilos gramnegativos y E. Coli fue el más común. La mayor sensibilidad fue a la amikacina y la mayor resistencia, a ampicillina, ciprofloxacilo y ácido nalidíxico. Muchas de las pacientes con mayor cantidad de ingresos tenían anomalías estructurales de las vías urinarias. La enfermedad subyacente más frecuentemente asociada fue la diabetes mellitus(AU)


A descriptive cross-sectional study was conducted to describe the behavior of recurrent acute pyelonephritis in women of 18 years of age and older who were admitted to Mártires del 9 de Abril Hospital in Sagua La Grande, from January 2004 to June 2007. The universe was composed of the 593 patients who were admitted with this diagnosis. A non-probabilistic sampling criterion was performed and then, the sample was composed of 67 patients. The ages ranged from 18 to 85 years. The most common clinical manifestations were low back pain, fever and low urinary symptoms. On physical examination, pain on deep palpation of the lumbar fosses was found, practically, in all cases. The diagnosis of certainty was made by urine culture in 104 occasions. The most common germs that infected the upper urinary tracts were gram-negative bacilli, and E. coli was the most common. The greatest sensitivity was seen for Amikacin and the resistance was greater to Ampicillin, Ciprofloxacin and Nalidixic Acid. Many of the patients with the majority of admissions presented structural anomalies of the urinary tract. The most frequently associated underlying disease was diabetes mellitus(AU)


Assuntos
Humanos , Feminino , Adolescente , Adulto Jovem , Adulto , Pessoa de Meia-Idade , Idoso , Pielonefrite/epidemiologia , Resistência Microbiana a Medicamentos , Infecções por Bactérias Gram-Negativas/patologia , Escherichia coli/patogenicidade , Epidemiologia Descritiva , Estudos Transversais/métodos
7.
Rev. cuba. med ; 52(3): 161-172, jul.-set. 2013.
Artigo em Espanhol | CUMED | ID: cum-56580

RESUMO

Se realizó un estudio descriptivo transversal para describir el comportamiento de la pielonefritis aguda recurrente en mujeres de 18 y más años de edad, que ingresaron en el Hospital Mártires del 9 de Abril de Sagua la Grande, de enero de 2004 a junio de 2007. El universo estuvo constituido por las 593 pacientes ingresadas con ese diagnóstico. Se realizó un muestreo no probabilístico por criterios y la muestra quedó constituida por 67 pacientes. Las edades fluctuaron entre 18 y 85 años. Las manifestaciones clínicas más comunes fueron: dolor lumbar, fiebre y síntomas urinarios bajos. En el examen físico se halló dolor a la palpación profunda de las fosas lumbares, prácticamente, en todos los casos. El diagnóstico de certeza se realizó por el urocultivo, en 104 ocasiones. Los gérmenes que con mayor frecuencia infectaron las vías urinarias altas fueron bacilos gramnegativos y E. Coli fue el más común. La mayor sensibilidad fue a la amikacina y la mayor resistencia, a ampicillina, ciprofloxacilo y ácido nalidíxico. Muchas de las pacientes con mayor cantidad de ingresos tenían anomalías estructurales de las vías urinarias. La enfermedad subyacente más frecuentemente asociada fue la diabetes mellitus(AU)


A descriptive cross-sectional study was conducted to describe the behavior of recurrent acute pyelonephritis in women of 18 years of age and older who were admitted to Mártires del 9 de Abril Hospital in Sagua La Grande, from January 2004 to June 2007. The universe was composed of the 593 patients who were admitted with this diagnosis. A non-probabilistic sampling criterion was performed and then, the sample was composed of 67 patients. The ages ranged from 18 to 85 years. The most common clinical manifestations were low back pain, fever and low urinary symptoms. On physical examination, pain on deep palpation of the lumbar fosses was found, practically, in all cases. The diagnosis of certainty was made by urine culture in 104 occasions. The most common germs that infected the upper urinary tracts were gram-negative bacilli, and E. coli was the most common. The greatest sensitivity was seen for Amikacin and the resistance was greater to Ampicillin, Ciprofloxacin and Nalidixic Acid. Many of the patients with the majority of admissions presented structural anomalies of the urinary tract. The most frequently associated underlying disease was diabetes mellitus(AU)


Assuntos
Humanos , Feminino , Adolescente , Adulto Jovem , Adulto , Pessoa de Meia-Idade , Idoso , Idoso de 80 Anos ou mais , Pielonefrite/diagnóstico , Técnicas de Diagnóstico Urológico , Coleta de Urina/métodos , Epidemiologia Descritiva , Estudos Transversais
8.
Rev. cuba. med ; 52(3): 161-172, jul.-set. 2013.
Artigo em Espanhol | LILACS | ID: lil-686485

RESUMO

Se realizó un estudio descriptivo transversal para describir el comportamiento de la pielonefritis aguda recurrente en mujeres de 18 y más años de edad, que ingresaron en el Hospital Mártires del 9 de Abril de Sagua la Grande, de enero de 2004 a junio de 2007. El universo estuvo constituido por las 593 pacientes ingresadas con ese diagnóstico. Se realizó un muestreo no probabilístico por criterios y la muestra quedó constituida por 67 pacientes. Las edades fluctuaron entre 18 y 85 años. Las manifestaciones clínicas más comunes fueron: dolor lumbar, fiebre y síntomas urinarios bajos. En el examen físico se halló dolor a la palpación profunda de las fosas lumbares, prácticamente, en todos los casos. El diagnóstico de certeza se realizó por el urocultivo, en 104 ocasiones. Los gérmenes que con mayor frecuencia infectaron las vías urinarias altas fueron bacilos gramnegativos y E. Coli fue el más común. La mayor sensibilidad fue a la amikacina y la mayor resistencia, a ampicillina, ciprofloxacilo y ácido nalidíxico. Muchas de las pacientes con mayor cantidad de ingresos tenían anomalías estructurales de las vías urinarias. La enfermedad subyacente más frecuentemente asociada fue la diabetes mellitus


A descriptive cross-sectional study was conducted to describe the behavior of recurrent acute pyelonephritis in women of 18 years of age and older who were admitted to Mártires del 9 de Abril Hospital in Sagua La Grande, from January 2004 to June 2007. The universe was composed of the 593 patients who were admitted with this diagnosis. A non-probabilistic sampling criterion was performed and then, the sample was composed of 67 patients. The ages ranged from 18 to 85 years. The most common clinical manifestations were low back pain, fever and low urinary symptoms. On physical examination, pain on deep palpation of the lumbar fosses was found, practically, in all cases. The diagnosis of certainty was made by urine culture in 104 occasions. The most common germs that infected the upper urinary tracts were gram-negative bacilli, and E. coli was the most common. The greatest sensitivity was seen for Amikacin and the resistance was greater to Ampicillin, Ciprofloxacin and Nalidixic Acid. Many of the patients with the majority of admissions presented structural anomalies of the urinary tract. The most frequently associated underlying disease was diabetes mellitus


Assuntos
Humanos , Feminino , Adolescente , Adulto Jovem , Pessoa de Meia-Idade , Idoso de 80 Anos ou mais , Técnicas de Diagnóstico Urológico , Pielonefrite/diagnóstico , Coleta de Urina/métodos , Estudos Transversais , Epidemiologia Descritiva
9.
Rev Neurol ; 53(11): 673-6, 2011 Dec 01.
Artigo em Espanhol | MEDLINE | ID: mdl-22086429

RESUMO

INTRODUCTION: Cardiological complications are the most frequent cause of mortality in the epileptic status. Takotsubo cardio-myopathy is a recently reported condition that can appear in a number of medical emergencies, including epileptic status. CASE REPORT: We present a case of Takotsubo cardiomyopathy within the context of an epileptic status and we also review similar cases reported in the literature. Special attention is given to the semiology and aetiology of the epileptic seizures, patients' epidemiological data, the alterations noted in the electrocardiogram and the complications that occurred. The patient, a 43-year-old female, recovered completely both cardiologically and neurologically, and did not suffer any relapses during the one-year follow-up. CONCLUSION: Takotsubo cardiomyopathy is a severe, treatable complication that can occur in the epileptic status.


Assuntos
Epilepsia/complicações , Cardiomiopatia de Takotsubo/etiologia , Adulto , Anticonvulsivantes/uso terapêutico , Eletrocardiografia , Epilepsia/tratamento farmacológico , Feminino , Humanos , Cardiomiopatia de Takotsubo/patologia
10.
Med. segur. trab ; 55(216): 56-64, jul.-sept. 2009. tab
Artigo em Espanhol | IBECS | ID: ibc-88894

RESUMO

La indicación de la ergometría en determinados colectivos de personas trabajadoras está recogida con la categoría IIa (opinión a favor de su utilidad) de la American Hearth Association. Los protocolos de vigilancia en salud laboral (Ministerio de Sanidad y Consumo) no recogen la realización de ergometrías. Objetivo: analizar los datos de ergometrías realizadas a 31 bomberos mayores de 44 años. Método: Se aplicó protocolo BRUCE sobre tapiz rodante. Se analizaron los siguientes datos: edad, consumo de tabaco, frecuencia cardiaca basal, PR, eje QRS, frecuencia cardiaca submáxima, TAS/TAD basal, TAS/TAD máxima, capacidad funcional, tiempo de duración de la prueba, colesterol total, HDL, LDL y glucemia. Se analizó el riesgo cardiovascular. Resultados: La media de edad fue de 48,82 años. El 29,03% eran fumadores. Los datos analítico fueron: glucemia 85,37 mg/100 cc, colesterol total 205 mg/100 cc, HDL 53,03 mg/100 cc, LDL 151,07 mg/100 cc. Buena respuesta al ejercicio físico. La capacidad funcional fue de 12,87 Mets, y la duración de 11,46 minutos. Conclusión: Incluir la ergometría en los protocolos de vigilancia de la salud para determinados colectivos de trabajadores (AU)


The indication of the ergometry in certain groups of hard–working persons is gathered by the categoryIIa (opinion in favour of its utility) of the American Hearth Association. The protocols of alertness in labourhealth (Ministry of Health and Consumption) do not gather the accomplishment of ergometry.Objective: to analyze the information of ergometry realized to 31 44–year–old major firemen.Method: Applied protocol BRUCE on rolling tapestry. The following information was analyzed: age,consumption of tobacco, cardiac frequency basal, PR, axis(axle) QRS, cardiac submaximum frequency, TAS/TAD basal, maximum TAS/TAD, functional capacity, time of duration of the test(proof), total cholesterol,HDL, LDL and glucose. The cardiovascular risk was analyzedResults: The average of age was 48,82 years. 29,03 % was smoking. The information analytical was:glycemia 85,37 mg/100 cc, total cholesterol 205 mg/100 cc, HDL 53,03 mg/100 cc, LDL 151,07 mg/100 cc.Good response to the physical exercise(fiscal year). The functional capacity was 12,87 Mets, and the durationof 11,46 minutes.Conclusion: To include the ergometry in the protocols of alertness of the health for certain groupsof workers (AU)


Assuntos
Humanos , Adulto , Sistemas de Combate a Incêndio , Ergonomia , Saúde do Trabalhador , Bombeiros
15.
Rev Esp Cardiol ; 60(5): 510-6, 2007 May.
Artigo em Espanhol | MEDLINE | ID: mdl-17535762

RESUMO

INTRODUCTION AND OBJECTIVES: The plasma N-terminal probrain natriuretic peptide (NT-proBNP) level is a sensitive marker of ventricular dysfunction. The diagnostic and prognostic value of urinary NT-proBNP measurement has been demonstrated. The objective of this study was to determine the relationship between established parameters of ventricular function and the urinary NT-proBNP level. METHODS: The study involved 74 patients with heart failure (54 male, age 66 [12] years). A Doppler echocardiographic study was performed to measure atrioventricular plane displacement (AVPD), ejection fraction, mitral flow propagation velocity, and E/A. Urinary and plasma NT-proBNP levels, and the plasma aldosterone level were measured. RESULTS: In the whole group, the plasma NT-proBNP level was 948 (961) pg/mL, the urinary NT-proBNP level was 88.7 (17.8) pg/mL, and the aldosterone level, 165 (145) pg/mL. There were correlations between urinary NT-proBNP level and AVPD (r=-0.5; P< .0001), ejection fraction (r=-0.3; P< .01), and mitral flow propagation velocity (r=-0.24; P< .05). On dividing AVPD and ejection fraction measurements into quartiles, respectively, the urinary NT-proBNP levels for these quartiles were Q1: 103 (28) pg/mL, Q2: 89 (9) pg/mL, Q3: 86 (9) pg/mL, and Q4: 78 (9) pg/mL (P< .0001) and Q1: 101 (26) pg/mL, Q2: 85 (12) pg/mL, Q3: 83 (10) pg/mL, and Q4: 85 (11) pg/mL (P< .05), respectively. Multiple linear regression analysis showed that the plasma NT-proBNP level was an independent predictor of the urinary NT-proBNP level (P< .0001). When the plasma NT-proBNP level was excluded, AVPD and ejection fraction appeared as alternative independent predictors (P< .05). CONCLUSIONS: There is a correlation between the urinary NT-proBNP level and left ventricular function parameters. This study supports the use of the urinary NT-proBNP level as a biochemical marker of ventricular function in heart failure patients.


Assuntos
Baixo Débito Cardíaco/fisiopatologia , Peptídeo Natriurético Encefálico/urina , Fragmentos de Peptídeos/urina , Função Ventricular/fisiologia , Idoso , Aldosterona/sangue , Biomarcadores/sangue , Biomarcadores/urina , Baixo Débito Cardíaco/diagnóstico por imagem , Baixo Débito Cardíaco/urina , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Peptídeo Natriurético Encefálico/sangue , Fragmentos de Peptídeos/sangue , Ultrassonografia
16.
Rev. esp. cardiol. (Ed. impr.) ; 60(5): 510-516, mayo 2007. ilus, tab
Artigo em Espanhol | IBECS | ID: ibc-058027

RESUMO

Introducción y objetivos. La concentración plasmática de N-terminal propéptido natriurético cerebral (NT-proBNP) es un marcador sensible de disfunción ventricular. Se ha demostrado el valor diagnóstico y pronóstico de sus concentraciones urinarias. Nuestro objetivo es determinar la relación entre parámetros consolidados de la función ventricular y concentraciones urinarias de NT-proBNP. Métodos. Hemos estudiado 74 pacientes diagnosticados de insuficiencia cardiaca (54 varones, edad 66 ± 12 años). Se les realizó un estudio eco-Doppler y se determinaron el desplazamiento del plano auriculoventricular (DPAV) (mm), la fracción de eyección (FE), la velocidad de propagación del flujo mitral (Vp) (cm/s) y la relación E/A. Se midieron las concentraciones plasmáticas y urinarias de NT-proBNP y las de aldosterona (pg/ml). Resultados. Para toda la población, los valores plasmáticos de NT-proBNP fueron 948 ± 961 pg/ml, los urinarios 88,7 ± 17,8 pg/ml y los de aldosterona 165 ± 145 pg/ml. Correlacionamos las concentraciones urinarias de NT-proBNP con el DPAV (r = -0,5; p < 0,0001), la FE (r = -0,3; p < 0,01) y con Vp (r = -0,24; p < 0,05). Dividimos los valores de DPAV y FE en cuartiles y en cada uno calculamos el NT-proBNP urinario (C1: 103 ± 28, C2: 89 ± 9, C3: 86 ± 9, C4: 78 ± 9; p < 0,0001 y C1: 101 ± 26, C2: 85 ± 12, C3: 83 ± 10, C4: 85 ± 11; p < 0,05). Al realizar un análisis de regresión lineal múltiple se muestra que NT-proBNP plasmático es un factor pronóstico independiente de NT-proBNP urinario (p < 0,0001). Si excluimos el NT-proBNP plasmático surgen de manera alternativa, como factores pronóstico independientes, el DPAV y la FE (p < 0,05). Conclusiones. El NT-proBNP en la orina se correlaciona con parámetros de función del ventrículo izquierdo. Este estudio da soporte al papel del NT-proBNP urinario como marcador bioquímico de la función ventricular en pacientes con insuficiencia cardiaca (AU)


Introduction and objectives. The plasma N-terminal probrain natriuretic peptide (NT-proBNP) level is a sensitive marker of ventricular dysfunction. The diagnostic and prognostic value of urinary NT-proBNP measurement has been demonstrated. The objective of this study was to determine the relationship between established parameters of ventricular function and the urinary NT-proBNP level. Methods. The study involved 74 patients with heart failure (54 male, age 66 [12] years). A Doppler echocardiographic study was performed to measure atrioventricular plane displacement (AVPD), ejection fraction, mitral flow propagation velocity, and E/A. Urinary and plasma NT-proBNP levels, and the plasma aldosterone level were measured. Results. In the whole group, the plasma NT-proBNP level was 948 (961) pg/mL, the urinary NT-proBNP level was 88.7 (17.8) pg/mL, and the aldosterone level, 165 (145) pg/mL. There were correlations between urinary NT-proBNP level and AVPD (r=-0.5; P<.0001), ejection fraction (r=-0.3; P<.01), and mitral flow propagation velocity (r=-0.24; P<.05). On dividing AVPD and ejection fraction measurements into quartiles, respectively, the urinary NT-proBNP levels for these quartiles were Q1: 103 (28) pg/mL, Q2: 89 (9) pg/mL, Q3: 86 (9) pg/mL, and Q4: 78 (9) pg/mL (P<.0001) and Q1: 101 (26) pg/mL, Q2: 85 (12) pg/mL, Q3: 83 (10) pg/mL, and Q4: 85 (11) pg/mL (P<.05), respectively. Multiple linear regression analysis showed that the plasma NT-proBNP level was an independent predictor of the urinary NT-proBNP level (P<.0001). When the plasma NT-proBNP level was excluded, AVPD and ejection fraction appeared as alternative independent predictors (P<.05). Conclusions. There is a correlation between the urinary NT-proBNP level and left ventricular function parameters. This study supports the use of the urinary NT-proBNP level as a biochemical marker of ventricular function in heart failure patients (AU)


Assuntos
Masculino , Feminino , Idoso , Humanos , Insuficiência Cardíaca/urina , Peptídeo Natriurético Encefálico/urina , Insuficiência Cardíaca/diagnóstico , Biomarcadores , Aldosterona/urina , Função Ventricular , Peptídeo Natriurético Encefálico/metabolismo
17.
Pediatr. aten. prim ; 7(27): 377-393, jul.-sept. 2005. ilus, tab
Artigo em Espanhol | IBECS | ID: ibc-041921

RESUMO

Objetivos: a través de este estudio, se pretende conocer cuáles son los hábitos posturales y conocimientos ergonómicos sobre las diferentes formas que utilizan los adolescentes a la hora de sentarse. Además se pretenden establecer relaciones entre las diferentes posiciones adoptadas (de atención, de escritura y de descanso) y la aparición de dolores de espalda. Material y método: desarrollo y aplicación de un cuestionario dirigido a una población de 700 adolescentes (n = 700) Y realizado en cinco centros de Educación Secundaria Obligatoria de Ponferrada, Toreno y Cacabelos (pertenecientes a la provincia de León). Resultados: se obtienen datos sobre las posiciones más utilizadas por los escolares en tres situaciones: posición de atención (explicación del profesor), posición de escritura (tomar apuntes) y posición de descanso (tiempo de ocio sentados en sus casas). Asimismo, se comprueba el elevado número de horas que pasan en posición sedente a lo largo del día y si las diferentes posiciones adoptadas tienen alguna influencia en el padecimiento de algias vertebrales. Conclusiones: el número de horas que los alumnos pasan en posición sedente provoca el incremento de desequilibrios musculares. Este factor, unido a un mobiliario mal adaptado ya la adopción de posturas incorrectas, puede incrementar el número de algias vertebrales padecidas a lo largo de sus vidas


Objedives: Through this study, it is intended to know which are the postural habits and ergonomic knowledge on the different ways that the adolescents adopt when sitting down. It also seeks to settle down relationships among the different adopted positions (of attention, of writing and of rest) and the appearance of back pain Material and method: We developed and applied a questionnaire directed to a population of 700 adolescents (n = 700) and carried out in five Compulsory Secondary Education schools in Ponferrada, Toreno and Cacabelos (belonging to the province of León). Results: Data are obtained on the positions more often adopted by the students in three situations: position of attention (the teacher's explanation), writing position (taking notes) and position of rest (time of leisure sitting down in their houses). Also it is pro ven the high number of hours that they spend in seated position along the day and if the different adopted positions ha ve any influence in the suffering of vertebral pains. Conclusions: The number of hours which students spend in seated position causes the increment of muscular imbalances. This factor together to a not well adapted furniture and to the adoption of incorrect postures can in crease the number of vertebral pains suffered along their lives


Assuntos
Masculino , Feminino , Adolescente , Humanos , Traumatismos da Coluna Vertebral/etiologia , Postura , Inquéritos e Questionários , Serviços de Saúde Escolar , Dor nas Costas/epidemiologia , Hábitos , Ergonomia
18.
Rev Esp Cardiol ; 57(5): 396-402, 2004 May.
Artigo em Espanhol | MEDLINE | ID: mdl-15151773

RESUMO

INTRODUCTION: N-terminal pro-brain natriuretic peptide (NT-proBNP) is useful in the diagnosis of heart failure. We compared NT-proBNP levels in patients with and without a diagnosis of arterial hypertension. PATIENTS AND METHOD: Participants were recruited from a random sample of 999 inhabitants from the Community of Valencia (eastern Spain). Of these patients, 432 said they suffered from dyspnea and were referred to their hospital (10 hospitals involved), where blood samples were taken, an echo-Doppler study was performed, and the patients completed a questionnaire. Of the 432 participants with dyspnea, 215 gave informed consent for their inclusion in the study, and 202 completed the study. Hypertension was diagnosed in 72 participants and 130 were normotensive. RESULTS: For the whole population, NT-proBNP, expressed as the median and range, was 88 (0-2586) pg/mL. When we compared hypertensive with normotensive participants, we found higher NT-proBNP levels in the former group: median 123, range 0-2184 pg/mL, versus median 77, range 0-2586 pg/mL (P<.01). When we excluded subjects with systolic left ventricular dysfunction, we found higher levels in participants with hypertension: 119 (0-2184 pg/mL) vs 72 (0-997 pg/mL) (P<.01). When we also excluded subjects with diastolic dysfunction, we found (median 85, range 0-430 pg/mL) and (median 66, range 0-997 pg/mL), respectively (p = NS). CONCLUSION: In a population study of subjects with dyspnea, hypertensive patients have higher NT-proBNP levels than subjects with normal blood pressure. This difference disappeared when patients with diastolic dysfunction were excluded from the analysis. Hypertension can thus be a confounding factor that potentially decreases the specificity of NT-proBNP levels for the diagnosis of heart failure. These findings should be taken into account when conducting clinical and epidemiological studies in which patients with both heart failure and hypertension are included.


Assuntos
Insuficiência Cardíaca/diagnóstico , Hipertensão/sangue , Proteínas do Tecido Nervoso/sangue , Fragmentos de Peptídeos/sangue , Idoso , Ecocardiografia Doppler , Feminino , Humanos , Hipertensão/diagnóstico por imagem , Masculino , Pessoa de Meia-Idade , Peptídeo Natriurético Encefálico , Inquéritos e Questionários
19.
Rev Esp Cardiol ; 56(11): 1043-9, 2003 Nov.
Artigo em Espanhol | MEDLINE | ID: mdl-14622534

RESUMO

INTRODUCTION AND OBJECTIVES: NT-proBNP is useful in the diagnosis of heart failure and ventricular dysfunction. Left atrioventricular plane displacement (AVPD) is a consolidated index of ventricular function. Our objective was to carry out a multicenter population-based study to establish the relationship between plasma NT-proBNP levels with AVPD values. PATIENTS AND METHOD: We studied 215 subjects (age 66 9 years; 57.7% women) chosen from a random sample of 432 people from the Community of Valencia, who previously reported suffering from some degree of dyspnea. Doppler echocardiography was done, AVPD was calculated and plasma NT-proBNP concentrations were determined. All studies were completed in 194 patients. RESULTS: For the whole population NT-proBNP was 88 (0-2,586) pg/ml and AVPD was 11.9 1.6 mm. NT-proBNP concentration correlated well with AVPD (r = 0.44; p < 0.00001), and higher peptide levels were obtained in AVPD quartiles that indicated less displacement (p < 0.05). When NT-proBNP values were grouped according to their association with AVPD lower or higher than the 50th percentile AVPD, the difference was significant at p < 0.01. When AVPD values lower and higher than 10 mm were compared, NT-proBNP values were higher in persons with AVPD lower than 10 mm (p < 0.05). CONCLUSIONS: This population study found higher NT-proBNP concentrations in subjects with lower AVPD, and illustrates the potential diagnostic usefulness of NT-proBNP in clinical practice.


Assuntos
Insuficiência Cardíaca/sangue , Proteínas do Tecido Nervoso/sangue , Fragmentos de Peptídeos/sangue , Precursores de Proteínas/sangue , Disfunção Ventricular Esquerda/sangue , Idoso , Estudos Transversais , Ecocardiografia Doppler em Cores , Feminino , Insuficiência Cardíaca/diagnóstico por imagem , Humanos , Masculino , Peptídeo Natriurético Encefálico , Reprodutibilidade dos Testes , Sensibilidade e Especificidade , Disfunção Ventricular Esquerda/diagnóstico por imagem
20.
Rev. esp. cardiol. (Ed. impr.) ; 56(11): 1043-1049, nov. 2003.
Artigo em Espanhol | IBECS | ID: ibc-27964

RESUMO

Introducción y objetivos. El N-terminal propéptido natriurético cerebral (NT-proBNP) es útil en el diagnóstico de la insuficiencia cardíaca y la disfunción ventricular. El desplazamiento del plano auriculoventricular (DPAV) es un índice consolidado de la función ventricular. Nuestro objetivo es relacionar en un estudio multicéntrico poblacional los valores plasmáticos del NT-proBNP y los valores del DPAV. Pacientes y método. Estudiamos a 215 sujetos (edad, 66 ñ 9 años; un 57,7 por ciento, mujeres) obtenidos de una muestra aleatoria de 432 personas de la Comunidad Valenciana que previamente declararon sufrir algún grado de disnea. Se realizó un estudio con eco-Doppler, se midió el DPAV y se determinó el valor plasmático de NTproBNP. El estudio se completó en 194 pacientes. Resultados. Para toda la población, el valor de NTproBNP fue de 88 pg/ml (rango, 0-2.586 pg/ml) y el valor del DPAV fue de 11,9 ñ 1,6 mm. Las concentraciones del péptido natriurético muestran una correlación con los valores del DPAV (r = 0,44; p < 0,00001) y su valores más elevados se observan en los cuartiles del DPAV con menor desplazamiento (p < 0,05). Cuando agrupamos los valores del NT-proBNP en menor o mayor del percentil 50 del DPAV, obtuvimos un valor de p < 0,01. Si dividimos el DPAV en mayor o menor de 10 mm, los valores de NT-proBNP son más elevados en los sujetos con DPAV menor de 10 mm (p < 0,05).Conclusiones. Este estudio poblacional muestra valores más altos de NT-proBNP en sujetos con un desplazamiento menor del plano auriculoventricular, y pone de manifiesto su potencial diagnóstico en la práctica clínica (AU)


Assuntos
Idoso , Masculino , Feminino , Humanos , Sensibilidade e Especificidade , Reprodutibilidade dos Testes , Disfunção Ventricular Esquerda , Ecocardiografia Doppler em Cores , Fragmentos de Peptídeos , Proteínas do Tecido Nervoso , Precursores de Proteínas , Estudos Transversais , Insuficiência Cardíaca
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA