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1.
Nat Med ; 29(1): 158-169, 2023 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-36624313

RESUMO

Richter syndrome (RS) arising from chronic lymphocytic leukemia (CLL) exemplifies an aggressive malignancy that develops from an indolent neoplasm. To decipher the genetics underlying this transformation, we computationally deconvoluted admixtures of CLL and RS cells from 52 patients with RS, evaluating paired CLL-RS whole-exome sequencing data. We discovered RS-specific somatic driver mutations (including IRF2BP2, SRSF1, B2M, DNMT3A and CCND3), recurrent copy-number alterations beyond del(9p21)(CDKN2A/B), whole-genome duplication and chromothripsis, which were confirmed in 45 independent RS cases and in an external set of RS whole genomes. Through unsupervised clustering, clonally related RS was largely distinct from diffuse large B cell lymphoma. We distinguished pathways that were dysregulated in RS versus CLL, and detected clonal evolution of transformation at single-cell resolution, identifying intermediate cell states. Our study defines distinct molecular subtypes of RS and highlights cell-free DNA analysis as a potential tool for early diagnosis and monitoring.

2.
Heliyon ; 8(12): e11934, 2022 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-36483304

RESUMO

Studies have found that Westerners recognize own-race faces with left visual lateralization (from the viewer's perspective), but whether subjects recognize own- and other-race faces with similar degrees of left visual lateralization is unclear. In the present study, two experiments were conducted to clarify this issue. In Experiment 1, faces were divided into left and right sides to ascertain whether Chinese subjects scanned the left side of Chinese and Western faces more often than the right side. In Experiment 2, facial features were divided into six areas of interest along the midline of the face (specifically, the left and right eyes, sides of the nose, and sides of the mouth) to determine whether Chinese subjects scanned facial features on the left side of Chinese and Western faces more often than on the right side. The results of Experiment 1 showed that the fixation counts and scanning duration for the left side of the face were greater than those for the right side of the face, with no significant effect from the race of the face. The results of Experiment 2 showed that the fixation counts and scanning duration of the left eye and left side of the mouth were greater than those of the right eye and right side of the mouth, respectively, whereas no significant effect was found between the left and right sides of the nose for either Chinese or Western faces. The results indicate that Chinese subjects recognize own- and other-race faces with similar left visual lateralization, which is mainly reflected in scanning of the eyes and mouth.

3.
Psych J ; 2022 Dec 13.
Artigo em Inglês | MEDLINE | ID: mdl-36513391

RESUMO

In real life, we are often motivated to plan things to be performed at specific times in the future. Some of these intended actions help other individuals, and thus involve time-based prospective memory (TBPM) under prosocial motivational conditions. Children's social development is very rapid, and they have relatively stable prosocial motivation during school age. Few studies have paid attention to this issue. This study focuses on three aspects of this issue: (1) the impact of prosocial motivation on the TBPM of school-age children, (2) whether there are sex differences in this effect, and, for the first time, (3) the processing mechanism by which prosocial motivation affects TBPM in school-age children in the framework of the motivation cognitive model. A total of 112 elementary school students, aged between 8 and 12, participated in the experiment, using a 2 (group: prosocial motivation, control) × 2 (sex: boy, girl) between-subjects design. The results showed that prosocial motivation can significantly reduce children's time difference of TBPM. However, we found no sex differences in the effect of prosocial motivation on TBPM in the above two indicators. With regard to the processing mechanism, we found that the prosocial motivation group paid more attention to external time information throughout the experiment. However, their internal attention and the effectiveness of attention did not improve. These results partially support the motivation cognitive model. Overall, this study found that prosocial motivation relies mainly on external attention to improve the TBPM performance of school-age children.

4.
Sci Rep ; 12(1): 18896, 2022 Nov 07.
Artigo em Inglês | MEDLINE | ID: mdl-36344573

RESUMO

People more accurately remember faces of their own racial group compared to faces of other racial groups; this phenomenon is called the other-race effect. To date, numerous researchers have devoted themselves to exploring the reasons for this other-race effect, and they have posited several theoretical explanations. One integrated explanation is the categorization-individuation model, which addresses two primary ways (categorization and individuation) of racial face processing and emphasizes the emergence of these two ways during the encoding stage. Learning-recognition and racial categorization tasks are two classical tasks used to explore racial face processing. Event-related potentials can facilitate investigation of the encoding differences of own- and other-race faces under these two typical task demands. Unfortunately, to date, results have been mixed. In the current study, we investigated whether categorization and individuation differ for own- and other-race faces during the encoding stage by using racial categorization and learning-recognition tasks. We found that task demands not only influence the encoding of racial faces, but also have a more profound effect in the encoding stage of recognition tasks for other-race faces. More specifically, own-race faces demonstrate deeper structural encoding than other-race faces, with less attentional involvement. Moreover, recognitions tasks might ask for more individual-level encoding, requiring more attentional resources in the early stage that may be maintained until relatively late stages. Our results provide some evidence concerning task selection for future racial face studies and establish a groundwork for a unified interpretation of racial face encoding.


Assuntos
Reconhecimento Facial , Humanos , Reconhecimento Psicológico , Potenciais Evocados , Grupos Raciais , Reconhecimento Visual de Modelos
5.
J Phys Chem Lett ; 13(37): 8783-8792, 2022 Sep 22.
Artigo em Inglês | MEDLINE | ID: mdl-36103381

RESUMO

Coherent longitudinal acoustic phonon (CAP) generation in epitaxial Dirac semimetal Cd3As2 films with different thicknesses was investigated by a time-resolved reflectance technique. The short-lived weak CAP oscillations can be observed only in the thicker Cd3As2 films, and their central frequency of 0.039 THz has no dependence on sample thickness, but is nearly inversely proportional to the probe wavelength. For the 20 nm thin film, the observed long-lived CAP with a central frequency of 0.049 THz is generated in the GaAs(111)B substrate underneath. A sound velocity of 3800 m/s for the Cd3As2 film and 5360 m/s for the GaAs(111)B substrate is thus deduced. In addition, the opposite CAP amplitude and lifetime dependence on temperature further confirms the electronic and thermal stress origination of CAP generated in GaAs(111)B and Cd3As2 film, respectively, based on the propagating strain pulse model. The central frequency of CAP is found to be stable with increasing pumping fluence and temperature, which makes Cd3As2 a potential material for thermoelectric device applications.

6.
Comput Intell Neurosci ; 2022: 1787369, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35655495

RESUMO

Keywords are usually one or more words or phrases that describe the subject information of the document. The traditional automatic keywords extraction methods cannot obtain the keywords which do not appear in the document, and the semantic information is not considered in the extraction process. In this paper, we introduce a novel Keyword Generation Model based on Topic-aware and Title-guide (KGM-TT). In the KGM-TT, the neural topic model is used to identify the latent topic words, and a hierarchical encoder technology with attention mechanism is able to encode the title and its content, respectively. The keywords are generated by the recurrent neural network with attention and replication mechanism in our model. This model can not only generate the keywords which do not appeared in the source document but also use the topic information and the highly summative word meaning in the title to assist the generation of keywords. The experimental results show that the F1 value of this model is about 10% higher than that of CopyRNN and CopyCNN.


Assuntos
Redes Neurais de Computação , Semântica
7.
J Healthc Eng ; 2022: 6938506, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35028123

RESUMO

Syndrome differentiation is the most basic diagnostic method in traditional Chinese medicine (TCM). The process of syndrome differentiation is difficult and challenging due to its complexity, diversity, and vagueness. Recently, artificial intelligent methods have been introduced to discover the regularities of syndrome differentiation from TCM medical records, but the existing DM algorithms failed to consider how a syndrome is generated according to TCM theories. In this paper, we propose a novel topic model framework named syndrome differentiation topic model (SDTM) to dynamically characterize the process of syndrome differentiation. The SDTM framework utilizes latent Dirichlet allocation (LDA) to discover the latent semantic relationship between symptoms and syndromes in mass of Chinese medical records. We also use similarity measurement method to make the uninterpretable topics correspond with the labeled syndromes. Finally, Bayesian method is used in the final differentiated syndromes. Experimental results show the superiority of SDTM over existing topic models for the task of syndrome differentiation.


Assuntos
Inteligência Artificial , Medicina Tradicional Chinesa , Algoritmos , Teorema de Bayes , Humanos , Medicina Tradicional Chinesa/métodos , Síndrome
8.
Nanoscale ; 14(6): 2383-2392, 2022 Feb 10.
Artigo em Inglês | MEDLINE | ID: mdl-35088779

RESUMO

Dirac semimetal (DSM) Cd3As2 has drawn great attention for exploring the novel quantum phenomena and high-speed optoelectronic applications. The circular photogalvanic effect (CPGE) current, resulting from the optically-excited spin orientation transport, was theoretically predicted to vanish in an ideal Dirac system due to the symmetric photoexcitation about the Dirac point. Here, we reported the observation of the CPGE photocurrent in epitaxial Cd3As2 thin films grown on a GaAs(111)B substrate. The signature of the CPGE is confirmed by its sign reversal upon switching the helicity of optical radiation, as well as its dependence on the excitation incident angle and power. By comparison of the CPGE response between the films with different thicknesses, it is suggested that the observed CPGE results from the reduced structure symmetry and substantially modified electronic band structure of the Cd3As2 thin film that undergoes large epitaxial strain. Our experimental findings provide a valuable reference for the band engineering and exotic helicity-dependent photocurrent phenomena in DSMs towards their potential opto-spintronic device applications.

9.
Q J Exp Psychol (Hove) ; 75(4): 742-753, 2022 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-34507499

RESUMO

The enactment effect refers to a phenomenon in which the memory performance for action phrases is enhanced by performing the described action (e.g., sharpen a pencil) compared with simply reading the action phrase. This produced effect can result in improved motor processing. This study investigated the contribution of semantic integration to the enactment effect by contrasting well-integrated phrases, such as "blow up the balloon," with poorly integrated phrases, such as "sew the toothpick," and analysing the N400 component of event-related potentials (ERPs). The subjects encoded action phrases with different degrees of semantic integration by either pretending to perform or reading action phrases. They then completed a phrase recognition test, while electroencephalographic signals were simultaneously recorded. The behavioural results showed that semantic integration improved memory performance under the motor encoding condition but not under the verbal encoding condition. The ERP results revealed that, regardless of whether it was an old (memorised) or new (distractor) phrase, a larger N400 component was elicited under the motor encoding condition than under the verbal encoding condition. In the motor encoding condition, poorly integrated phrases elicited a larger N400 component than well-integrated phrases; in the verbal encoding condition, this effect was not observed. The N400 effect associated with semantic processing was enhanced by semantic integration under the motor encoding condition rather than the verbal encoding condition. These results supported a deep semantic processing mechanism under the motor encoding condition, and a semantic feedback processing mechanism for the enactment effect was partially supported.


Assuntos
Eletroencefalografia , Semântica , Cognição , Potenciais Evocados , Retroalimentação , Feminino , Humanos , Masculino
10.
Front Immunol ; 12: 727464, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34899689

RESUMO

Background: PD-1/PD-L1 inhibitor immunotherapy has showed impressive activity in various cancers, especially relapsed/refractory (r/r) classical Hodgkin lymphoma (cHL). However, acquired resistance is inevitable for most patients. Sometimes severe side effects also lead to treatment termination. When immunotherapy failed, alternative treatment options are limited. In the past few years, we have used the anti-angiogenic agent apatinib and PD-1 inhibitor camrelizumab to treat cHL patients who failed prior immunotherapy. In this study, we analyzed the data of these patients. Patients and Methods: Patients with r/r cHL who had failed immunotherapy and subsequently received apatinib-camrelizumab (AC) combination therapy were included in this study. Patient data were collected from medical records and follow-up system. The efficacy and safety of AC therapy were analyzed. Results: Seven patients who failed immunotherapy were identified in our database, of which five patients acquired immunotherapy resistance and two patients experienced severe side effects. They received a combination of camrelizumab (200 mg every four weeks) and apatinib (425 mg or 250 mg per day). As of the cut-off date, these patients had received a median of 4 cycles (range, 2 - 31) of treatment. Two (2/7) patients achieved complete response, four (4/7) partial response, and one (1/7) stable disease. The median progression-free survival was 10.0 months (range, 2.0 - 27.8). Low-dose apatinib (250 mg) plus camrelizumab was well tolerated and had no unexpected side effects. Besides, no reactive cutaneous capillary endothelial proliferation was observed in AC-treated patients. Conclusions: Low dose apatinib plus camrelizumab might be a promising treatment option for r/r cHL patients who have failed immunotherapy. This combination treatment is worthy of further investigation in more patients including solid cancer patients who have failed immunotherapy.


Assuntos
Anticorpos Monoclonais Humanizados/administração & dosagem , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Doença de Hodgkin/tratamento farmacológico , Piridinas/administração & dosagem , Adulto , Inibidores da Angiogênese/administração & dosagem , Resistencia a Medicamentos Antineoplásicos/efeitos dos fármacos , Feminino , Humanos , Inibidores de Checkpoint Imunológico/administração & dosagem , Masculino , Recidiva Local de Neoplasia/tratamento farmacológico , Estudos Retrospectivos , Adulto Jovem
11.
Front Oncol ; 11: 735817, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34722284

RESUMO

PURPOSE: To identify whether chemoradiotherapy improves survival of stage I nasopharyngeal carcinoma (NPC). MATERIALS AND METHODS: NPC patients were extracted from the Surveillance, Epidemiology, and End Results database between 2010 and 2015. Pathologically confirmed stage T1N0M0 (the 7th edition AJCC) were investigated. Overall survival (OS) and cancer-specific survival (CSS) were compared between the radiotherapy and chemoradiotherapy groups using the Kaplan-Meier method and propensity score matching (PSM) analyses. RESULTS: This study included 91 (40.27%) patients in the chemoradiotherapy group and 135 (59.73%) patients in the radiotherapy group. Before PSM, chemoradiotherapy was associated with worse 3-year OS (74.31 vs 87.23%; P = 0.025) and 5-year OS (64.28 vs 83.12%; P = 0.001) compared to those associated with radiotherapy. Similarly, chemoradiotherapy showed worse 3-year CSS (87.01 vs 96.97%; P = 0.028) and 5-year CSS (80.39 vs. 96.97%; P = 0.002) than those of radiotherapy. After PSM, chemoradiotherapy revealed worse 5-year OS (63.10 vs. 82.49%; P = 0.031) and CSS (80.95 vs. 93.70%; P = 0.016) than radiotherapy. The multivariate regression analysis revealed that chemoradiotherapy was an independent risk prognostic factor for OS and CSS before and after PSM. CONCLUSION: Radiotherapy alone is recommended for stage I NPC patients.

12.
Nanoscale ; 13(24): 10712-10725, 2021 Jun 24.
Artigo em Inglês | MEDLINE | ID: mdl-34128524

RESUMO

Tip-Enhanced Raman Spectroscopy (TERS) provides very high spatial resolution and detection sensitivity, so it has important applications in nano-scale molecular analysis. Plexciton is a polarization mode caused by a strongly coupled interaction between plasma excitons and excitons. It is a hot topic in plasma photonics research. We introduce the characteristics, production methods, observation methods and some applications of TERS. The electric field gradient (EFG) is an important factor affecting TERS resolution. The electron-phonon interaction is a fundamental inelastic interaction and plays an important role in current-carrying single-molecular junctions. This article summarizes the characteristics and applications of these three parts for readers to gain a preliminary understanding.

13.
Front Pharmacol ; 12: 651976, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33967793

RESUMO

Breast cancer is the most common malignancy in women and is a molecularly heterogeneous disease. Signal transducer and activator of transcription 3 (Stat3) is overexpressed and hyperactivated in a variety of human tumours, including breast cancer, thus representing a promising target for breast cancer treatment. In the present study, we evaluated the activities of a novel Stat3 inhibitor named Statmp-151 in the human breast cancer cell lines MCF-7 and MDA-MB-231 and the murine mammary carcinoma cell line 4T1. The in vitro results showed that Statmp-151 inhibited the proliferation of breast cancer cell lines in a dose- and time-dependent manner and suppressed the phosphorylation of Stat3 in a dose-dependent manner. Flow cytometry (FCM) assays revealed that Statmp-151 affected mitochondrial membrane potential and reactive oxygen species (ROS) production. Furthermore, Statmp-151 inhibited cell migration, as shown by analysis of the matrix metalloproteinases MMP2 and MMP9. Finally, in a 4T1 tumour-bearing mouse model, intraperitoneal injection of 30 mg/kg/day Statmp-151 significantly suppressed the growth of tumours without obvious toxicity. These results indicated that Statmp-151 might be a potential candidate for the treatment of breast cancer.

14.
J Phys Condens Matter ; 33(31)2021 Jun 14.
Artigo em Inglês | MEDLINE | ID: mdl-34020432

RESUMO

The magneto-transport properties of cubic NiMnAs film epitaxied on the GaAs (110) substrate are investigated. The x-ray diffraction measurements reveal that the NiMnAs (111) crystal plane is parallel to the GaAs (110) crystal plane. The temperature dependence of resistivity at high temperature can be described by a thermal activation model, from which the thermal activation energy is obtained and found to be comparable with many other Heusler alloys. By fitting the temperature dependence of resistivity at low temperature, the coefficient of the quadratic temperature term is determined to be 1.34 × 10-3µΩ cm K-2. This value suggests the possible presence of single-magnon scattering in the NiMnAs film. The negative magnetoresistance is attributed to the suppression of the spin-dependent scattering, which would not take place in a half-metal. The angle dependence of the anisotropic magnetoresistance (AMR) is measured, and the AMR ratios are positive even at low temperature. These magneto-transport properties indicate that the predicted half-metallicity is destroyed in the NiMnAs film. The absence of the half-metallicity may be attributed to the atomic disorder in the NiMnAs lattice, which needs to be confirmed by further experimental and theoretical studies.

15.
Mitochondrial DNA B Resour ; 5(1): 614-615, 2020 Jan 14.
Artigo em Inglês | MEDLINE | ID: mdl-33366671

RESUMO

Calophaca sinica Rehd. is a tree species with high economic value, whose resource has been declining due to unreasonable exploitation. In this study, we sequenced, assembled, and annotated the complete chloroplast genome of C. sinica. The whole chloroplast genome size is 129,345 bp, it lacks an inverted repeat (IR) region. The GC content of the whole chloroplast genome is 34.51%. The chloroplast genome comprises 112 unique genes, including 77 protein-coding genes (PCGs), 30 transfer RNA (tRNA) genes, and 5 ribosomal RNA (rRNA) genes. Phylogenetic analyses of chloroplast genomes derived from 15 species indicated that C. sinica is close to Caragana and Tibetia species in Papilionoideae.

16.
ACS Omega ; 5(48): 30849-30857, 2020 Dec 08.
Artigo em Inglês | MEDLINE | ID: mdl-33324794

RESUMO

Artemisinin and its derivatives are of great research value in biology. In this work, we study their chiral and optical properties. The multidimensional multifunction analysis method is used to analyze the linear and nonlinear optical processes (one-photon and two-photon absorption: OPA and TPA), electronic circular dichroism (ECD), and Raman optical activity (ROA) mechanisms under light excitation. Transition dipole moments (TDMs) and charge difference density (CDD) are used to describe the electromagnetic interaction between ECD and ROA when a substance is excited by light. The theoretical research results of the study show that the dioxygen atoms provide an intermediary for the transfer between charges and also enhance the role of the TDMs. This generalized chiral theory can not only explain the traditional sources of chirality but also distinguish whether the molecule has chirality when the chiral center is not obvious. By analyzing ROA and different vibration modes, we can clearly observe that each part of the molecule responds differently when excited.

17.
Biomark Res ; 8: 33, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32864130

RESUMO

BACKGROUND: Early progression after the first-line R-CHOP treatment leads to a very dismal outcome and necessitates alternative treatment for patients with diffuse large B-cell lymphoma (DLBCL). This study aimed to develop a genetic predictive model for early progression and evaluate its potential in advancing alternative treatment. METHODS: Thirty-two hotspot driver genes were examined in 145 DLBCL patients and 5 DLBCL cell lines using next-generation sequencing. The association of clinical features, cell-of-origin, double expression, positive p53 protein, and gene alterations with early progression was analyzed, and the genetic predictive model was developed based on the related independent variables and assessed by the area under receiver operating characteristic. The potential of novel treatment based on the modeling was investigated in in-vitro DLBCL cell lines and in vivo xenograft mouse models. RESULTS: The frequency of CD79B (42.86% vs 9.38%, p = 0.000) and PIM1 mutations (38.78% vs 17.71%, p = 0.005) showed a significant increase in patients with early progression. CD79B and PIM1 mutations were associated with complex genetic events, double expression, non-GCB subtype, advance stage and unfavorable prognosis. A powerful genetic predictive model (AUROC = 0.771, 95% CI: 0.689-0.853) incorporating lactate dehydrogenase levels (OR = 2.990, p = 0.018), CD79B mutations (OR = 5.970, p = 0.001), and PIM1 mutations (OR = 3.021, p = 0.026) was created and verified in the other cohort. This modeling for early progression outperformed the prediction accuracy of conventional International Prognostic Index, and new molecular subtypes of MCD and Cluster 5. CD79B and PIM1 mutations indicated a better response to inhibitors of BTK (ibrutinib) and pan-PIM kinase (AZD 1208) through repressing activated oncogenic signaling. Since the two inhibitors failed to decrease BCL2 level, BCL2 inhibitor (venetoclax) was added and demonstrated to enhance their apoptosis-inducing activity in mutant cells with double expression. CONCLUSIONS: The genetic predictive model provides a robust tool to identify early progression and determine precision treatment. These findings warrant the development of optimal alternative treatment in clinical trials.

18.
Evol Bioinform Online ; 16: 1176934320925752, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32565674

RESUMO

Pseudouridine (Ψ) is the first discovered and the most prevalent posttranscriptional modification, which has been widely studied during the past decades. Pseudouridine was observed in almost all kinds of RNAs and shown to have important biological functions. Currently, the time-consuming and high-cost procedures of experimental approaches limit its uses in real-life Ψ site detection. Alternatively, by taking advantage of the explosive growth of Ψ sequencing data, the computational methods may provide a more cost-effective avenue. To date, the existing mouse Ψ site predictors were all developed based on sequence-derived features, and their performance can be further improved by adding the domain knowledge derived feature. Therefore, it is highly desirable to propose a genomic feature-based computational method to increase the accuracy and efficiency of the identification of Ψ RNA modification in the mouse transcriptome. In our study, a predictive framework PSI-MOUSE was built. Besides the conventional sequence-based features, PSI-MOUSE first introduced 38 additional genomic features derived from the mouse genome, which achieved a satisfactory improvement in the prediction performance, compared with other existing models. Moreover, PSI-MOUSE also features in automatically annotating the putative Ψ sites with diverse types of posttranscriptional regulations (RNA-binding protein [RBP]-binding regions, miRNA-RNA interactions, and splicing sites), which can serve as a useful research tool for the study of Ψ RNA modification in the mouse genome. Finally, 3282 experimentally validated mouse Ψ sites were also collected in a database with customized query functions. For the convenience of academic users, a website was built to provide a user-friendly interface for the query and analysis on the database. The website is freely accessible at www.xjtlu.edu.cn/biologicalsciences/psimouse and http://psimouse.rnamd.com. We introduced the genome-derived features to mouse for the first time, and we achieved a good performance in mouse Ψ site prediction. Compared with the existing state-of-art methods, our newly developed approach PSI-MOUSE obtained a substantial improvement in prediction accuracy, marking the reliable contributions of genomic features for the prediction of RNA modifications in a species other than human.

19.
Int J Psychol ; 55(3): 456-464, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-31187498

RESUMO

Recently, cross-cultural facial-expression recognition has become a research hotspot, and a standardised facial-expression material system can significantly help researchers compare and demonstrate the results of other studies. We developed a facial-expression database of Chinese Han, Hui and Tibetan ethnicities. In this study, six basic human facial expressions (and one neutral expression) were collected from 200 Han, 220 Hui and 210 Tibetan participants who lived in these regions. Four experts on each ethnicity evaluated the facial-expression images according to the expressions, and only those achieving inter-rater agreement were retained. Subsequently, 240 raters evaluated these images according to the seven emotions and rated the intensity of the expressions. Consequently, 2980 images were included in the database, including 930 images of Han individuals, 962 images of Hui individuals and 1088 images of Tibetan individuals. In conclusion, the facial-expression database of Chinese Han, Hui and Tibetan people was representative and reliable with a recognition rate of over 60%, making it well-suited for cross-cultural research on emotions.


Assuntos
Expressão Facial , Adulto , China/etnologia , Feminino , Humanos , Masculino , Tibet/etnologia , Adulto Jovem
20.
J Biomed Nanotechnol ; 16(10): 1504-1517, 2020 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-33422162

RESUMO

Tenofovir (TFV), an acyclic nucleoside analog, exhibits potent anti-HBV activity. However, poor bioavailability, nephrotoxicity and bone toxicity limit its further clinical application. In this work, a novel tenofovir-loaded glycyrrhetinic acidmodified cationic liposome (TGCL) was prepared for targeted therapy of HBV. The TGCL had an average particle size of 107.39 ± 1.21 nm and an entrapment efficiency of 89.83 ± 2.70% with a positive zeta potential of 37.63 ± 1.22 mV. The results of in vitro indicated that the inhibitory effects on HBsAg, HBeAg and HBV cccDNA of TGCL in HepG2.2.15 cells were significantly better than that of free TFV and non-targeted cationic liposome. In the DHBV-infected duck model, TGCL showed remarkably suppression on DHBV DNA than that of free TFV. Overall, TGCL is a promising formulation of TFV for targeted therapy of HBV.


Assuntos
Antivirais , Ácido Glicirretínico , Hepatite B , Animais , DNA Viral/uso terapêutico , Ácido Glicirretínico/uso terapêutico , Vírus da Hepatite B , Lipossomos , Tenofovir/uso terapêutico
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