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1.
Chempluschem ; 85(3): 405-410, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-32118370

RESUMO

By virtue of an efficient rhodium(III)-catalyzed redox-neutral C-H activation/ring-opening of a strained ring/[4+2] annulation cascade of N-methoxybenzamides with propargyl cycloalkanols, diverse 3-acyl isoquinolin-1(2H)-ones were directly obtained in good yields and with excellent functional group compatibility. Additionally, their antitumor activities against various human cancer cells including HepG2, A549, MCF-7 and SH-SY5Y were evaluated and the action mechanism of the selected compound was also investigated in vitro. The results revealed that these products possessed a potent efficacy, by inhibiting proliferation and inducing apoptosis in a time-dependent and dose-dependent manner, suggesting that such compounds can serve as promising candidates for anti lung cancer drug discovery.

2.
Neural Netw ; 125: 281-289, 2020 Feb 26.
Artigo em Inglês | MEDLINE | ID: mdl-32151915

RESUMO

Rectified activation units make an important contribution to the success of deep neural networks in many computer vision tasks. In this paper, we propose a Parametric Deformable Exponential Linear Unit (PDELU) and theoretically verify its effectiveness for improving the convergence speed of learning procedure. By means of flexible map shape, the proposed PDELU could push the mean value of activation responses closer to zero, which ensures the steepest descent in training a deep neural network. We verify the effectiveness of the proposed method in the image classification task. Extensive experiments on three classical databases (i.e., CIFAR-10, CIFAR-100, and ImageNet-2015) indicate that the proposed method leads to higher convergence speed and better accuracy when it is embedded into different CNN architectures (i.e., NIN, ResNet, WRN, and DenseNet). Meanwhile, the proposed PDELU outperforms many existing shape-specific activation functions (i.e., Maxout, ReLU, LeakyReLU, ELU, SELU, SoftPlus, Swish) and the shape-adaptive activation functions (i.e., APL, PReLU, MPELU, FReLU).

3.
J Colloid Interface Sci ; 569: 140-149, 2020 Feb 17.
Artigo em Inglês | MEDLINE | ID: mdl-32105901

RESUMO

A bifunctional electrocatalyst with peculiarly hierarchical snowflake-like iron-doped CoP heterostructures self-assembled on copper foam (CoFeP/CF) was synthesized via a facile hydrothermal-phosphidation pathway. The excellent electrochemical performance of CoFeP/CF can be attributed to the synergistic effect of cobalt and iron atoms, tuneful interaction between metal atoms and phosphorus, and the large electrochemical active surface area origined from its peculiarly hierarchical snowflake-like heterostructures with high surface roughness. With the small Tafel slope values (of 73.0 mV dec-1 for OER and 90.4 mV dec-1 for HER), CoFeP/CF demands the diminutive overpotentials (of 277.9 mV for OER and 152.6 mV for HER) to desire the current density of 50 mA cm-2 in alkaline electrolyte. Furthermore, CoFeP/CF exhibits outstanding electrochemical performance for the overall water splitting with the cell potential of 1.495 V to attain 10 mA cm-2 in a two-electrode cell.

4.
Artigo em Inglês | MEDLINE | ID: mdl-32054588

RESUMO

As an important part of high-speed train (HST), the mechanical performance of bogies imposes a direct impact on the safety and reliability of HST. It is a fact that, regardless of the potential mechanical performance degradation status, most existing fault diagnosis methods focus only on the identification of bogie fault types. However, for application scenarios such as auxiliary maintenance, identifying the performance degradation of bogie is critical in determining a particular maintenance strategy. In this article, by considering the intrinsic link between fault type and performance degradation of bogie, a novel multiple convolutional recurrent neural network (M-CRNN) that consists of two CRNN frameworks is proposed for simultaneous diagnosis of fault type and performance degradation state. Specifically, the CRNN framework 1 is designed to detect the fault types of the bogie. Meanwhile, CRNN framework 2, which is formed by CRNN Framework 1 and an RNN module, is adopted to further extract the features of fault performance degradation. It is worth highlighting that M-CRNN extends the structure of traditional neural networks and makes full use of the temporal correlation of performance degradation and model fault types. The effectiveness of the proposed M-CRNN algorithm is tested via the HST model CRH380A at different running speeds, including 160, 200, and 220 km/h. The overall accuracy of M-CRNN, i.e., the product of the accuracies for identifying the fault types and evaluating the fault performance degradation, is beyond 94.6% in all cases. This clearly demonstrates the potential applicability of the proposed method for multiple fault diagnosis tasks of HST bogie system.

5.
ISME J ; 2020 Jan 31.
Artigo em Inglês | MEDLINE | ID: mdl-32005978

RESUMO

Vertebrates' gut microbial communities can be altered by the hosts' parasites. Helminths inhabiting the gut lumen can interact directly with their host's microbiota via physical contact, chemical products, or competition for nutrients. Indirect interactions can also occur, for instance when helminths induce or suppress host immunity in ways that have collateral effects on the microbiota. If there is genetic variation in host immune responses to parasites, we would expect such indirect effects to be conditional on host genotype. To test for such genotype by infection interactions, we experimentally exposed Gasterosteus aculeatus to their naturally co-evolved parasite, Schistocephalus solidus. The host microbiota differed in response to parasite exposure, and between infected and uninfected fish. The magnitude and direction of microbial responses to infection differed between host sexes, and also differed between variants at autosomal quantitative trait loci. These results indicate that host genotype and sex regulate the effect of helminth infection on a vertebrate gut microbiota. If this result holds in other taxa, especially humans, then helminth-based therapeutics for dysbiosis might need to be tailored to host genotype and sex.

6.
Biomacromolecules ; 21(3): 1202-1213, 2020 Mar 09.
Artigo em Inglês | MEDLINE | ID: mdl-31895550

RESUMO

Regulating cell migration dynamics is of significance in tissue engineering and regenerative medicine. A 3D scaffold was created to provide various topographies based on a poly(ε-caprolactone) (PCL) self-induced nanohybrid shish-kebab structure, which consisted of aligned PCL nanofibers and spaced PCL crystal lamellae grown on the fibers. Electrospinning was applied followed by self-induced crystallization. The results resembled natural collagen fibrils in an extracellular matrix. This variable microstructure enabled control of cell adhesion and migration. The kebab size was controlled by initial PCL concentrations. The geometry of cells seeded on the fibers was less elongated, but the adhesion was more polarized with a higher nuclear shape index and faster migration speed. These results could aid in rapid endothelialization in tissue engineering.

7.
Chemosphere ; 246: 125786, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-31918097

RESUMO

The choice of anode materials has a significant influence on the electrocatalytic degradation of organics. Accordingly, the electrocatalytic activity of several active anodes (Ti/Ru-Ir, Ti/Ir-Ta, Ti/Pt) and non-active anodes (Ti/PbO2, Ti/SnO2, Si/BDD (boron-doped diamond)) was compared by electrocatalytic degradation of m-cresol. The results indicated Si/BDD electrode had the strongest mineralization ability and the lowest energy consumption. And the order of the activity of m-cresol degradation was as follows: Si/BDD > Ti/SnO2>Ti/PbO2>Ti/Pt > Ti/Ir-Ta > Ti/Ru-Ir. Also their intermediate products were compared. The effects of experimental parameters on electrocatalytic degradation of m-cresol with Si/BDD electrode showed m-cresol conversion was affected slightly by the electrode spacing and electrolyte concentration, but affected greatly by the temperature and current density. And smaller electrode spacing and current density, higher electrolyte concentration and temperature were beneficial to reduce energy consumption. Their degradation processes were all accord with the pseudo-first-order reaction kinetics completely. In addition, the results of electrocatalytic degradation of m, o, p-cresol indicated there was almost no significant difference on conversion rate between cresols isomers with the current density of 30 mA cm-2. However, the influence of group position was shown when the current density was reduced to 10 mA cm-2 and cresols conversion followed the sequence of m-cresol ≈ o-cresol > p-cresol.

8.
Anim Biotechnol ; : 1-3, 2020 Jan 16.
Artigo em Inglês | MEDLINE | ID: mdl-31944161

RESUMO

Toxoplasma gondii (T. gondii) and Neospora caninum (N. caninum) are protozoan parasites that cause severe disease in animals and significant economic losses for farmers worldwide. Neospora caninum is considered to be a serious parasite for dairy cows, while T. gondii infection is a serious parasitic disease that can infect people and livestock. The aim of the present study was to investigate the seroprevalence of T. gondii and N. caninum in dairy cows in Hebei province, China. A total of 723 dairy cow sera samples from three regions in Hebei were analyzed by enzyme-linked immunosorbent assays (ELISA). The results revealed that 19.92% (144/723) of the individual serum samples were seropositive for T. gondii, 37.34% (270/723) of the individual serum samples were seropositive for N. caninum, and 8.7% (63/723) of the individual serum samples were seropositive for mixed infection. A higher seroprevalence of N. caninum was found in the present study, when compared to previous data. To the best of the author's knowledge, the present study is the first to detect T. gondii and N. caninum antibodies in the vast areas of Hebei province, China.

9.
J Coll Physicians Surg Pak ; 30(1): 37-40, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31931930

RESUMO

OBJECTIVE: To determine the expression levels and clinical significance of serum N-terminal pro-brain natriuretic peptide (NT-proBNP), hydrogen sulfide (H2S) and interleukin-6 (IL-6) in children with Kawasaki disease (KD). STUDY DESIGN: Descriptive comparative study. PLACE AND DURATION OF STUDY: Department of Pediatric Medicine, Baoding Children's Hospital, from July 2017 to July 2018. METHODOLOGY: Ninety-five KD children were chosen as the case group, and were classified into CAL group (23 patients) and NCAL group (72 patients, according to the presence of a coronary artery lesion (CAL). Forty-six non-KD children with an upper respiratory infection in the same time period were chosen as the control group. Electrochemiluminescence method was used to detect serum NT-proBNP levels. The spectrophotometer method was used to test H2S levels, and an enzyme-linked immunosorbent assay was used to test serum IL-6 levels and to analyse the correlation. RESULTS: In the acute phase and recovery phase, serum NT-proBNP and IL-6 levels were higher in the case group than the control group, while H2S levels were lower than those in the control group (p<0.001). In both the acute and recovery phases, serum NT-proBNP and IL-6 levels were higher in the CAL group than in the NCAL group, while H2S levels were lower than those in the NCAL group (p<0.001). CONCLUSION: NT-proBNP and IL-6 levels rise and the H2S level decreases in the blood of KD children, indicating that these indicators may participate in the pathogenesis of KD and that their levels are related to CAL occurrence and the vascular inflammatory response.

10.
J Oral Pathol Med ; 2020 Jan 24.
Artigo em Inglês | MEDLINE | ID: mdl-31981240

RESUMO

BACKGROUND: Oral squamous cell carcinoma (OSCC) is a normal form of mouth cancer, comprising the majority of oral cancers. A large number of long non-coding RNAs (lncRNAs) have been reported due to their oncogenic function in cancers. Recent studies show that lncRNA CCHE1 is an oncogene in a wide range of cancers. Whether CCHE1 accelerates the progression of OSCC is still undiscovered. METHODS: The qRT-PCR analysis was used to determine CCHE1, miR-922 and PAK2 expression levels. CCK8 and colony formation assays were applied to evaluate OSCC cell proliferative ability. Transwell assay was performed to investigate the capability of cell migration and invasion. Cell apoptosis was assessed by flow cytometry analysis. The distribution of CCHE1 in OSCC cells was confirmed via subcellular fractionation assay. Luciferase reporter assay was used to verify the connection between miR-922 and CCHE1 or PAK2. RESULTS: qRT-PCR analysis identified the up-regulation of CCHE1 in OSCC cells. Knockdown of CCHE1 curbed the proliferation, migration and invasion and hastened the apoptosis in OSCC cell lines. Moreover, it was found that miR-922 could interact with CCHE1. Besides, PAK2 was identified as the target gene of miR-922 and its expression was negatively modulated by miR-922 and positively regulated by CCHE1. Restoration assay manifested that the suppressing influence of CCHE1 depletion on OSCC progression was rescued by amplified PAK2. CONCLUSIONS: CCHE1 increases the expression of PAK2 to promote the progression of OSCC by competitively binding to miR-922 in OSCC cells.

11.
ChemSusChem ; 13(2): 351-359, 2020 Jan 19.
Artigo em Inglês | MEDLINE | ID: mdl-31721453

RESUMO

Transition metal phosphides (TMPs) are regarded as highly active electrocatalysts for the hydrogen evolution reaction (HER). However, traditional synthetic routes usually use expensive and dangerous precursors as P donors. The development of a low-cost and ecofriendly method for the synthesis of TMPs is significant for sustainable energy development. Herein, cobalt phosphides anchored on or embedded in a spirulina-derived porous N-doped carbon matrix (Co2 P/NC) was fabricated by two-step hydrothermal treatment and carbonization method, which utilized the intrinsic C, N, and P of biomass cleverly as the sources of C, N, and P, respectively. As a result of the high surface area and porosity that enhance the mass-transfer dynamics, Co2 P/NC shows good electrocatalytic activity at all pH values in the HER. This work not only provides a facile and effective method for the fabrication of TMP nanoparticles loaded onto carbon materials but also opens a new strategy for the utilization of the intrinsic ingredients of biomass for the preparation of other functional electrocatalysts.


Assuntos
Hidrogênio/química , Nanopartículas Metálicas/química , Fosfinas/química , Spirulina/química , Concentração de Íons de Hidrogênio , Porosidade
12.
Eur J Pharm Sci ; 142: 105153, 2020 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-31740393

RESUMO

Both entecavir and crizotinib are substrates of organic cation transporter 2 (OCT2). The aim of present study was to investigate the mechanisms of drug interactions between these two drugs. Kinetic analysis of entecavir on crizotinib uptake was conduct. Plasma concentration of crizotinib in rats and lung cancer patients, uptake of crizotinib in kidney slices and OCT2 transfected cells, were determined by LC-MS/MS. The clinical pharmacokinetic interactions and impact on adverse reaction of crizotinib in lung cancer patients were investigated. Steady-state through concentration of crizotinib was measured. The crizotinib-related adverse reactions were recorded in lung cancer patients with and without entecavir. Entecavir and 1-methyl-4-phenylpyridinium iodide significantly inhibited the uptake of crizotinib in kidney slices. Kinetic constants for crizotinib uptake by OCT2 were Km 1.16 ± 0.26 µM, Vmax 12.05 ± 0.53 µmol/min mg-1 protein and Ki 9.711 nM. Entecavir can inhibit crizotinib transport by OCT2 in kidney. Co-administration of entecavir significantly reduced the elimination of crizotinib in rats. In lung cancer patients, the steady-state AUCss of crizotinib increased approximately 1.2 fold (p < 0.05) but clearance was decreased by approximately 15% in the presence of entecavir. Steady-state through concentration of crizotinib significantly increased 1.3-fold when co-administrated with entecavir (p>0.001). Co-medication of entecavir significantly (p < 0.05) increased the risks of vision disorders, diarrhea and vomiting 1.6-, 2.3- and 1.8-fold. Entecavir could increase the exposure and reduce the elimination of crizotinib in lung cancer patients. Moreover, the presence of entecavir could significantly increase the incidences of adverse reaction of crizotinib.

13.
Parasitol Res ; 119(1): 23-30, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31760499

RESUMO

The wide application of pyrethroids has led to the rapid development of insecticide resistance in mosquitoes, leading to a rise in mosquito-borne diseases. We previously identified five differentially expressed lipase family genes upon evaluating the transcriptomes of deltamethrin-resistant and deltamethrin-susceptible strains of Culex pipiens pallens. Herein, the gene expression levels were verified by quantitative real-time PCR, and two lipase family genes, lipase A and pancreatic triacylglycerol lipase A, were chosen for further investigations. Using cell viability assays and Centers for Disease Control and Prevention bottle bioassays, lipase A was found to increase the resistance of mosquitoes against deltamethrin both in vitro and in vivo. Our findings indicate that lipase A is involved in conferring deltamethrin resistance in Cx. pipiens pallens.

14.
J Ethnopharmacol ; 249: 112437, 2020 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-31794788

RESUMO

ETHNOPHARMACOLOGICAL RELEVANCE: Migraine is a disabling neurovascular disorder, which increases risk of cardiovascular events and is a social burden worldwide. The present first-line anti-migraine medications can cause overwhelming side-effects, of which one includes the onset of cardiovascular disease. As one of the marketed Tibetan drugs, Ru-yi-Zhen-bao Pills (RYZBP) have been clinically used to treat cardiovascular disorders and as anti-migraine medication. However, there is currently no research exploring the anti-migraine actions of RYZBP. AIM OF THE STUDY: The current research was designed to assess the anti-migraine roles of RYZBP and explore the underlying mechanisms in a nitroglycerin (NTG)-induced migraine rat model trial. MATERIALS AND METHODS: 120 rats were randomly divided into the following six groups of 20 rats each: normal control group, model control group, positive control group, and RYZBP high/medium/low-dose groups (Ru-yi-Zhen-bao Pills; TH 1.00 g/kg, TM 0.50 g/kg and TL 0.25 g/kg). All rats were administered intragastrically for 7 consecutive days, which were subcutaneously injected with the NTG (10 mg/kg) after the last gavage (except in the normal control group). 3min after NTG treatment, 30 rats (5 rats from each group) were anesthetized and devoted to electroencephalogram(EEG) testing, which was used to evaluate the analgesic effect of RYZBP. One hour after NTG treatment, the rest of the 90 rats (15 rats from each group) were anesthetized and midbrain tissue sample was dissected. The dissection was then washed with physiological saline and collected. The histopathological changes in the periaqueductal gray(PAG) of 5 tissue samples were determined by aematoxylin-eosin (H&E) staining, as well as an estimation of substance P (SP) and neurokinin 1 receptor (NK1R) expression through immunohistochemically staining(IHC). Another 5 midbrain preparations were carried out to evaluate calcitonin gene-related peptide (CGRP), proenkephalin (PENK), SP, and cholecystokinin (CCK) expressions by real-time quantitative polymerase chain reaction (RT-qPCR). The rest of the 5 brainstem tissues were then used to measure CCK, CGRP, and opioid peptide receptor (DORR) levels by western blotting(WB). RESULTS: In the EEG test, RYZBP (TM 0.50 g / kg) treatment transformed the EEG pain-wave of the NTG-induced migraine model rats in different time period. In the mechanism assay, compared with the model control group, RYZBP pretreatment reduced inflammatory cell infiltration, fibrosis and vacuolation of neuronal cells of PAG tissue seen by HE staining. IHC experiments further showed that RYZBPTM up-regulated SP expression levels and enhanced NK1R levels in the NTG-induced migraine rats (P < 0.05). Therapeutic administration of RYZBP also increased PENK mRNA expression and DORR protein level. Both RT-qPCR and western blotting trials indicated that RYZBP treatment significantly decreased CCK and CGRP expression levels (P < 0.01 or P < 0.05) in the NTG-induced migraine rats. CONCLUSIONS: RYZBP has the potential to be an effective anti-migraine treatment through suppressing the EEG pain-wave, increasing the levels of SP, PENK, DORR and reducing expression of CCK and CGRP. Mediating the PAG anti-nociceptive channel and inhibiting central sensitization were the two potential mechanisms, which offers further evidence for clinical therapy.

15.
Eur J Med Chem ; 187: 111913, 2020 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-31837501

RESUMO

In order to produce an effective and multi-targeted clinical drug that could prevent progressive neurodegeneration, a series of diosgenin carbamate derivatives were designed, synthesized and tested for their anti-inflammatory, antioxidant and anti-Aß activities. The results demonstrated that compound M15 was the most promising derivative against inflammatory (NO inhibition 22.7 ± 2.2%,10 µM) and cellular damage induced by H2O2 (SH-SY5Y cell protection = 75.3 ± 3.4%, 10 µM) or Aß (astrocytes protection = 70.2 ± 6.5%, 10 µM). Molecular docking studies revealed the strong binding affinity of M15 to the active site of nNOS, Aß42 and pro-inflammatory proteins. Western blot demonstrated that M15 decreased IL-1ß, IL-6 and TNF-α level, which may contribute to its anti-inflammatory effects. In addition, M15 maintained mitochondrial function as well as cell viability through reducing H2O2-induced ROS production. The results indicated that oral administration of M15 attenuated memory deficits and played a neuroprotective effect on subcutaneous (s.c.) D-gal aging mice. In summary, M15 could be considered as a potential multifunctional neuroprotective agent due to the effects of anti-inflammatory, antioxidant and anti-Aß activities.

16.
IEEE Trans Neural Netw Learn Syst ; 31(1): 66-75, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-30892241

RESUMO

This paper studies an adaptive neural network (NN) tracking control method for a class of uncertain nonlinear strict-feedback systems with time-varying full-state constraints. As we all know, the states are inevitably constrained in the actual systems because of the safety and performance factors. The main contributions of this paper are that: 1) in order to ensure that the states do not violate the asymmetric time-varying constraint regions, an adaptive NN controller is constructed by introducing the asymmetric time-varying barrier Lyapunov function (TVBLF) and 2) the amount of the learning parameters is reduced by introducing a TVBLF at each step of the backstepping. Based on the Lyapunov stability analysis, it can be proven that all the signals in the closed-loop system are the semiglobal ultimately uniformly bounded and the time-varying full-state constraints are never violated. Finally, a numerical simulation is given, and the effectiveness of this adaptive control method can be verified.

17.
Sci Total Environ ; 706: 136048, 2020 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-31864135

RESUMO

Methane (CH4) oxidation in well-aerated grassland soils is an important sink for atmospheric CH4, which can be largely modified by land-use changes. However, the impacts of land-use changes (i.e., from native grasslands to artificial grasslands (AG) and croplands (CL)) on soil CH4 uptake in China remain uncertain. Therefore, the 2-year CH4 flux was measured from 3 land-use types, including heavily grazed steppe (HG, control), AG, and CL, in the agro-pastoral ecotone of Northern China to elucidate this impact. Moreover, a meta-analysis was conducted to elucidate this effect across Chinese grasslands. The results showed that the land-use types could not change the seasonal patterns but significantly (p < 0.05) influenced the strength of soil CH4 uptake. The mean annual CH4 uptake followed the decreasing order of 14.7 ± 0.48 (mean ± 1 standard error) (CL), 3.28 ± 0.09 (AG), and 1.24 ± 0.07 kg CH4-C ha-1 yr-1 (HG) in 2012-2014. This spatial variation pattern was linear and negatively (n = 6, radj.2= 0.73, p < 0.05) associated with the annual mean soil water-filled pore space. Non-growing season CH4 uptake contributed 22-46% to the annual CH4 uptake across land-use types. The meta-analysis also confirmed that the land-use changes significantly (p < 0.05) promoted the annual soil CH4 uptake in temperate grasslands in China. This increased uptake is primarily related to the significant (p < 0.05) decrease in the soil water contents and the increase in the sand contents due to the land-use changes. Furthermore, nitrogen application not exceeding 100 kg N ha-1 yr-1 in these N-limited ecosystems significantly (p < 0.05) promoted soil CH4 uptake. Collectively, our study demonstrated that land-use changes combined with low N application promoted soil CH4 uptake in the temperate grasslands of China.

18.
J Cell Physiol ; 235(3): 3056-3068, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-31538341

RESUMO

Oral squamous cell carcinoma (OSCC) is one of the most common types of malignancies worldwide, and its morbidity and mortality have increased in the near term. Consequently, the purpose of the present study was to identify the notable differentially expressed genes (DEGs) involved in their pathogenesis to obtain new biomarkers or potential therapeutic targets for OSCC. The gene expression profiles of the microarray datasets GSE85195, GSE23558, and GSE10121 were obtained from the Gene Expression Omnibus (GEO) database. After screening the DEGs in each GEO dataset, 249 DEGs in OSCC tissues were obtained. Kyoto Encyclopedia of Genes and Genomes and Gene Ontology pathway enrichment analysis was employed to explore the biological functions and pathways of the above DEGs. A protein-protein interaction network was constructed to obtain a central gene. The corresponding total survival information was analyzed in patients with oral cancer from The Cancer Genome Atlas (TCGA). A total of six candidate genes (CXCL10, OAS2, IFIT1, CCL5, LRRK2, and PLAUR) closely related to the survival rate of patients with oral cancer were identified, and expression verification and overall survival analysis of six genes were performed based on TCGA database. Time-dependent receiver operating characteristic curve analysis yields predictive accuracy of the patient's overall survival. At the same time, the six genes were further verified by quantitative real-time polymerase chain reaction using samples obtained from the patients recruited to the present study. In conclusion, the present study identified the prognostic signature of six genes in OSCC for the first time via comprehensive bioinformatics analysis, which could become potential prognostic markers for OCSS and may provide potential therapeutic targets for tumors.

19.
J Hazard Mater ; 383: 121117, 2020 02 05.
Artigo em Inglês | MEDLINE | ID: mdl-31518802

RESUMO

Nitrous oxide (N2O) is an important ozone-depletion substance and greenhouse gas. Selective catalytic reduction (SCR) of N2O by CO is considered an effective method for N2O elimination. However, O2 exhibited a significant inhibition effect on the catalytic performance of N2O reduction by CO. A series of iron-based catalysts were prepared to investigate the effect of O2 in SCR of N2O by CO. The Fe-Z-pH2 (Fe-ZSM-5 ion-exchanged under pH of 2) catalyst manifested superior activity at low temperature and excellent O2 resistance in N2O reduction process. The characterization results from UV-vis DR spectra and XPS indicated that α-sites are the main active sites in Fe-Z-pH2, and they were inert to O2 but highly active to N2O. It could be concluded that the competition effect between N2O and O2 was very important over different catalysts. O2 is more prevalent over α-Fe2O3 catalyst, while N2O dominates over Fe-Z-pH2 catalyst. Moreover, in the presence of O2, Fe-Z-pH2 exhibited better performance for N2O removal than non-noble mixed oxide catalysts, which might broaden the application of low-temperature SCR of N2O by CO.

20.
J Hazard Mater ; 382: 121032, 2020 01 15.
Artigo em Inglês | MEDLINE | ID: mdl-31557576

RESUMO

The CeO2 catalysts grafted with heteropoly acid (i.e., HPA) could enhance their catalytic performance for selective catalytic reduction of NOx with NH3 (NH3-SCR). In comparison to HSiW/CeO2, HPMo/CeO2, and commercial V2O5-WO3/TiOx catalysts, HPW/CeO2 catalysts showed the best SCR performance. XPS and DRIFTS demonstrated that the amount of HPA on HPW/CeO2 was more than those on HSiW/CeO2 and HPMo/CeO2. H2-TPR results indicated that reducibility of HPMo/CeO2 was stronger than those of HSiW/CeO2 and HPW/CeO2, resulting in the high-temperature performance loss. According to kinetic results, below 250 °C, kSCR-ER and kSCR-LH of HPW/CeO2 were higher than those of HSiW/CeO2, meanwhile kside of both HSiW/CeO2 and HPW/CeO2 were low. Therefore, HPW/CeO2 had the better SCR performance than HSiW/CeO2. As NH3 was completely consumed, SCR activity depended on the ratio of SCR reaction in the consumption of NH3. The selectivity of SCR reaction, NSCR reaction, and C-O reaction of HSiW/CeO2 were almost the same as those of HPW/CeO2 above 250 °C, resulting in the NOx conversion of HPW/CeO2 was basically the same as that of HSiW/CeO2 above 250 °C. Due to the lowest kSCR-ER and kSCR-LH, and highest kside, NOx conversion of HPMo/CeO2 was the worst compared to HSiW/CeO2 and HPW/CeO2 catalysts.

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