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1.
Cien Saude Colet ; 25(3): 1119-1128, 2020 Mar.
Artigo em Português | MEDLINE | ID: mdl-32159679

RESUMO

The scope of this work was to identify the prevalence of domestic violence against non-institutionalized elderly individuals, and to establish if violence is an independent factor associated with the Physical Component (PC) and Mental Component (MC) scores of the Health-Related Quality of Life (HRQOL) of these elderly individuals. It is a cross-sectional epidemiologic and population-based investigation that is part of the SABE (Wellbeing, Health and Aging) study. A sample of 1,126 elderly individuals filled out the Short-Form 12 (SF-12) Health Survey, namely a generic instrument that assesses HRQOL through the Physical and Mental components. The prevalence of domestic violence against of the elderly was 10% (CI 95% 9.1-13.6). In the multiple analyses, violence against the elderly was significantly associated to the MC (ß = -3.03; p = 0.000) and to the PC (ß = -1.69; p = 0.017) of HRQOL, independently of the sociodemographic, health, family support, and functional incapacity covariables. The prevalence of domestic violence was high and compromised the physical and mental health of the elderly.

3.
Beilstein J Org Chem ; 15: 2644-2654, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31807199

RESUMO

This work describes a novel fluorescent 2,1,3-benzothiadiazole derivative designed to act as a water-soluble and selective bioprobe for plasma membrane imaging. The new compound was efficiently synthesized in a two-step procedure with good yields. The photophysical properties were evaluated and the dye proved to have an excellent photostability in several solvents. DFT calculations were found in agreement with the experimental data and helped to understand the stabilizing intramolecular charge-transfer process from the first excited state. The new fluorescent derivative could be applied as selective bioprobe in several cell lines and displayed plasma-membrane affinity during the imaging experiments for all tested models.

4.
Artigo em Inglês | MEDLINE | ID: mdl-31818054

RESUMO

Cognitive performance plays a key role in sports performance, especially in combat sports such as mixed martial arts (MMA). Studies with active and sedentary individuals showed either no change or decreased cognitive performance during or immediately after exercise. However, it is possible that elite MMA athletes would present preserved/improved cognitive performance after exhaustive exercise. In this series of cases studies, we tested this hypothesis by submitting three elite MMA athletes from the Bellator MMA® and UFC® to a cognitive assessment before, immediately after and 15 min after exhaustive exercise. A modified computerized version of the Stroop Test was used to test cognitive inhibition performance, from which reaction time (RT) and accuracy were obtained. The athletes performed an incremental exercise on a cycle simulator until volitional exhaustion. Immediately after exercise RT improved consistently in all three athletes (-6.5%; -8.0%; -15.0%), while accuracy presented a small increase (2.6%), decreases (-3.8%) or no change. Fifteen minutes after exercise, RT remained improved in two athletes (-9.1% and -15.5) or slightly increased (0.4%), while accuracy presented small increase in all athletes (0.5%; 1.3%; 2.1%) compared to pre-exercise. This result indicates that elite MMA athletes may present improved cognitive performance immediately after exhaustive exercise, which suggests that cognitive-motor training for MMA should be considered when planning a training program.

5.
J Neuroeng Rehabil ; 16(1): 141, 2019 Nov 15.
Artigo em Inglês | MEDLINE | ID: mdl-31730494

RESUMO

Transcranial Direct Current Stimulation (tDCS) is a non-invasive technique used to modulate neural tissue. Neuromodulation apparently improves cognitive functions in several neurologic diseases treatment and sports performance. In this study, we present a comprehensive, integrative review of tDCS for motor rehabilitation and motor learning in healthy individuals, athletes and multiple neurologic and neuropsychiatric conditions. We also report on neuromodulation mechanisms, main applications, current knowledge including areas such as language, embodied cognition, functional and social aspects, and future directions. We present the use and perspectives of new developments in tDCS technology, namely high-definition tDCS (HD-tDCS) which promises to overcome one of the main tDCS limitation (i.e., low focality) and its application for neurological disease, pain relief, and motor learning/rehabilitation. Finally, we provided information regarding the Transcutaneous Spinal Direct Current Stimulation (tsDCS) in clinical applications, Cerebellar tDCS (ctDCS) and its influence on motor learning, and TMS combined with electroencephalography (EEG) as a tool to evaluate tDCS effects on brain function.

6.
J Pain ; 2019 Sep 09.
Artigo em Inglês | MEDLINE | ID: mdl-31513934

RESUMO

This systematic review investigated the effectiveness and safety of botulinum toxin type A (BTX-A) for painful temporomandibular disorders. We searched for randomized controlled trials (RCTs) in 10 databases, from inception to February 12, 2019 (MEDLINE, EMBASE, CENTRAL, LILACS, BBO, Web of Science, Scopus, ClinicalTrials.gov, WHO and OpenGrey). We included 12 RCTs that compared BTX-A versus inactive or active interventions. BTX-A was slightly more effective than placebo for pain reduction at 1 month: mean difference -1.74 points (0-10 scale), 95% confidence interval -2.94 to -.54, 3 RCTs, 60 participants, I-square (I2) = 0%. However, there were no significant differences at 3 and 6 months. BTX-A was similar to no treatment for pain reduction at 3 and 6 months. BTX-A was more effective than conventional treatment and low-level laser therapy for pain reduction at 1, 6, and 12 months, but less effective than facial manipulation for pain reduction at 3 months. BTX-A was not associated with a significant increase in the risk of adverse events. The quality of the evidence was low, and results are insufficient to support the use of BTX-A for painful temporomandibular disorders. High-quality RCTs are needed to increase confidence in effect estimates. PERSPECTIVE: BTX-A for painful temporomandibular disorders appears to be well tolerated. For pain reduction, BTX-A is slightly more effective than placebo only at 1 month; conventional treatment and low-level laser at 1, 6, and 12 months. Low-quality evidence limits the applicability of these findings and precludes recommendations for practice.

7.
Rev Bras Ortop (Sao Paulo) ; 54(2): 165-170, 2019 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-31363262

RESUMO

Objective To determine if the sesamoids migrate laterally in the feet with hallux valgus or if they only appear to move, maintaining their relationship with the other forefoot structures. Methods Anteroposterior radiographs of 80 patients (94 feet, all weight-bearing), from the period between 2015 and 2016, were evaluated. Forty-eight had a valgus hallux angle greater than 15° (hallux valgus group) and 46 presented a hallux valgus angle lower than 15° (control group). The distances from the first metatarsus head and the lateral sesamoid bone to the second metatarsus axis were measured. Subsequently, the coefficients of these distances were determined by the length of the second metatarsus to adjust it for different foot sizes. Results Both the absolute and the relative measures from the first metatarsus head to the second metatarsus axis were significantly different between the groups, with a positive correlation with hallux valgus and intermetatarsal angles. However, neither the absolute nor the relative distance of the lateral sesamoid bone to the second metatarsus was different between the groups, as they did not correlate with hallux valgus or intermetatarsal angles. Conclusion Despite the medial deviation of the first metatarsus in hallux valgus, the sesamoid bone maintains its relationship with the second metatarsus in the transverse plane. This apparent lateral displacement may lead to misinterpretation of these radiographs. This fact is of paramount importance in the pre-, intra-, and postoperative period of patients with hallux valgus.

8.
Artigo em Inglês | MEDLINE | ID: mdl-31404425

RESUMO

Objective: Endometriosis has a complex and multifactorial pathology, and it is considered one of the main causes of infertility nowadays. The angiogenic process, which involves remodeling of extracellular matrix, is crucial for the development of this disease, mainly by the action of the matrix metalloproteinase 3 (MMP-3). It is known that genetic factors can influence endometriosis, thus; we investigated the role of MMP3 276G>A polymorphism as a risk factor for the development of the disease and its symptoms. Study Design: This case-control study included 283 women with endometriosis (cases) and 217 women without the disease (controls) who were submitted to laparoscopic or laparotomy surgery. Real-time polymerase chain reaction performed by TaqMan system was applied for all polymorphisms. A multivariate logistic regression was performed to evaluate the association between polymorphism and endometriosis or clinical and gynecological characteristics of the disease, using their respective odds ratios (OR) and 95% confidence intervals (CI). Results: The allelic frequency of the MMP3 276 G > A polymorphism was 33.6% in controls and 40.3% in endometriosis cases. The allelic distribution was significantly different between the two (P = 0.03). The variant genotype of MMP3 276AA was associated with increased endometriosis risk in the advanced endometriosis cases (OR: 2.08, 95% CI: 1.05 - 4.07 and OR: 1.87, 95% CI: 1.01 - 3.45). Regarding the symptoms, endometriosis-related infertile women had a positive association with the presence of MMP3 276 G > A polymorphism (OR: 3.13, 95% CI: 1.08-9.08 and OR: 3.30, 95% CI: 1.31 - 8.33). Conclusions: These findings suggest that the MMP3 276A polymorphism is involved with advanced endometriosis cases and infertility, and these associations may implicate in the behavior of disease.

9.
Mater Sci Eng C Mater Biol Appl ; 102: 405-414, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31147011

RESUMO

Graphene is one of the crystalline forms of carbon, along with diamond, graphite, carbon nanotubes, and fullerenes, and is considered as a revolutionary and innovating product. The use of a graphene-based nanolabels is one of the latest and most prominent application of graphene, especially in the field of diagnosis and, recently, in loco radiotherapy when coupled with radioisotopes. However, its biological behavior and mutagenicity in different cell or animal models, as well as the in vivo functional activities, are still unrevealed. In this study we have developed by a green route of synthesizing graphene quantum dots (GQDs) and characterized them. We have also developed a methodology for direct radiolabeling of GQDs with radioisotopes.Finally; we have evaluated in vivo biological behavior of GQDs using two different mice models and tested in vitro mutagenicity of GQDs. The results have shown that GQDs were formed with a size range of 160-280 nm, which was confirmed by DRX and Raman spectroscopy analysis, corroborating that the green synthesis is an alternative, environmentally friendly way to produce graphene. The radiolabeling test has shown that stable radiolabeled GQDs can be produced with a high yield (>90%). The in vivo test has demonstrated a ubiquitous behavior when administered to healthy animals, with a high uptake by liver (>26%) and small intestine (>25%). Otherwise, in an inflammation/VEGF hyperexpression animal model (endometriosis), a very peculiar behavior of GQDs was observed, with a high uptake by kidneys (over 85%). The mutagenicity test has demonstrated A:T to G:C substitutions suggesting that GQDs exhibits mutagenic activity.


Assuntos
Grafite/química , Química Verde/métodos , Mutagênicos/toxicidade , Pontos Quânticos/química , Compostos Radiofarmacêuticos/química , Tecnécio/química , Animais , Difusão Dinâmica da Luz , Feminino , Masculino , Camundongos Endogâmicos BALB C , Neovascularização Fisiológica , Fenômenos Ópticos , Tamanho da Partícula , Ratos Wistar , Análise Espectral Raman , Distribuição Tecidual , Difração de Raios X
10.
Rev. enferm. UFPE on line ; 13(5): 1444-1453, maio 2019. ilus, tab
Artigo em Português | BDENF - Enfermagem | ID: biblio-1024628

RESUMO

Objetivo: avaliar a qualidade e a duração do sono de enfermeiros pós-graduandos de mestrado e doutorado. Método: trata-se de um estudo quantitativo, descritivo, de natureza observacional e analítica, com amostra constituída por conveniência, com 32 estudantes que preencheram o questionário Índice de Qualidade do Sono de Pittsburgh (PSQI), a escala de Sonolência de Epworth (ESE), avaliando-se a atividade e a vigília pela actigrafia. Realizou-se o Teste t e de Wilcoxon para verificar se existiam diferenças entre a qualidade de sono, os níveis de sonolência excessiva e as medidas do actígrafo. Analisaram-se as diferenças significativas das variáveis qualitativas pelo teste Qui-quadrado e apresentaram-se os resultados em forma de tabelas. Resultados: exibiram-se, por 68,75% dos participantes, distúrbios do sono (PSQI> 5). Constatou-se o tempo total de sono com média de 368,8 minutos, sendo menor em quem faz uso de álcool (p=0.01). Conclusão: devem-se educar, a partir disso, os pós-graduandos sobre a importância da duração adequada do sono para a prevenção de riscos.(AU)


Objective: to evaluate the duration and quality of sleep of post-graduate nurses (Masters and Doctorate students). Method: this is a quantitative, descriptive, observational and analytical study with a convenience sample of 32 students who completed the Pittsburgh Sleep Quality Index (PSQI), and the Epworth Sleepiness Scale (ESS), evaluating the activity and wakefulness by the actigraphy. The Wilcoxon test and the Student's Ttest were performed to verify if there were differences among sleep quality, levels of excessive drowsiness and measures of the actigraph. It was analyzed the significant differences of the qualitative variables by the Chi-square test and presented the results in the form of tables. Results: sleep disorders (PSQI> 5) were present in 68.75% of the participants. The total time of sleep was 368.8 minutes, being lower in those who drank alcoholic beverages (p = 0.01). Conclusion: post-graduate students should be educated about the importance of adequate sleep duration for prevention of future problems.(AU)


Objetivo: evaluar la calidad y la duración del sueño de enfermeros post graduados de maestría y doctorado. Método: es un estudio cuantitativo, descriptivo, de naturaleza observacional y analítica, con muestra constituida por conveniencia, con 32 estudiantes que llenaron el cuestionario Índice de Calidad del Sueño de Pittsburgh (PSQI), la escala de Sonolencia de Epworth (ESE ), evaluándose la actividad y la vigilia por la actigrafía. Se realizó la prueba t y de Wilcoxon para verificar si existían diferencias entre la calidad del sueño, los niveles de somnolencia excesiva y las medidas del actígrafo. Se analizaron las diferencias significativas de las variables cualitativas por el test Chi-cuadrado y se presentaron los resultados en forma de tablas. Resultados: se exhibieron, por el 68,75% de los participantes, disturbios del sueño (PSQI> 5). Se constató el tiempo total de sueño con promedio de 368,8 minutos, siendo menor en quien hace uso de alcohol (p = 0.01). Conclusión: se debe educar, a partir de eso, a los postgraduados sobre la importancia de la duración adecuada del sueño para la prevención de riesgos. Descriptores: Sueño; Estudiantes de Enfermería; Trastornos del Sueño-Vigilia; actigrafía; Trastornos del inicio y del mantenimiento del sueño; Enfermería.(AU)


Assuntos
Humanos , Masculino , Feminino , Adulto , Sono , Transtornos do Sono-Vigília , Estudantes de Enfermagem , Educação de Pós-Graduação em Enfermagem , Distúrbios do Início e da Manutenção do Sono , Enfermeiras e Enfermeiros , Epidemiologia Descritiva , Actigrafia
11.
Org Biomol Chem ; 17(18): 4498-4511, 2019 05 08.
Artigo em Inglês | MEDLINE | ID: mdl-30990513

RESUMO

Herein we report the first systematic investigation of the tandem mercury(ii) catalysed transvinylation/Hurd-Claisen rearrangement of MBH adducts derived from alkyl acrylates. This is the first report of E-selectivity for MBH adducts with alkyl side chains and is complementary to the previously reported Johnson-Claisen and Eschenmoser-Claisen rearrangements. The rearrangement products were obtained in good yields and could be readily converted to 2-alkenyl δ-valerolactones. Combined DFT and F-SAPT studies demonstrate that reaction rates are primarily governed by non-covalent interactions dictating the relative stability of the transition states. Our F-SAPT calculations revealed that the hyperconjugative effects are not so significant, but that electrostatic interactions, instead, are the driving forces for the relative E : Z stereoselectivity.

12.
Rev. bras. ortop ; 54(2): 165-170, Mar.-Apr. 2019. tab, graf
Artigo em Inglês | LILACS | ID: biblio-1013694

RESUMO

Abstract Objective To determine if the sesamoids migrate laterally in the feet with hallux valgus or if they only appear to move, maintaining their relationship with the other forefoot structures. Methods Anteroposterior radiographs of 80 patients (94 feet, all weight-bearing), from the period between 2015 and 2016, were evaluated. Forty-eight had a valgus hallux angle greater than 15° (hallux valgus group) and 46 presented a hallux valgus angle lower than 15° (control group). The distances from the firstmetatarsus head and the lateral sesamoid bone to the secondmetatarsus axis weremeasured. Subsequently, the coefficients of these distances were determined by the length of the second metatarsus to adjust it for different foot sizes. Results Both the absolute and the relativemeasures from the firstmetatarsus head to the second metatarsus axis were significantly different between the groups, with a positive correlationwith hallux valgus and intermetatarsal angles. However, neither the absolute nor the relative distance of the lateral sesamoid bone to the second metatarsus was different between the groups, as they did not correlate with hallux valgus or intermetatarsal angles. Conclusion Despite the medial deviation of the first metatarsus in hallux valgus, the sesamoid bone maintains its relationship with the second metatarsus in the transverse plane. This apparent lateral displacement may lead to misinterpretation of these radiographs. This fact is of paramount importance in the pre-, intra-, and postoperative period of patients with hallux valgus.


Resumo Objetivo Determinar se os sesamoides migramlateralmente nos pés comhálux valgo ou se apenas aparentam deslocar-se, mantendo sua relação com as demais estruturas do antepé. Métodos Foram avaliadas radiografias na incidência anteroposterior com carga dos pés de 80 pacientes (94 pés) entre o período de 2015 e 2016. Dessas, 48 tinham ângulo de hálux valgo maior do que 15º (grupo hálux valgo) e 46 tinham ângulo de hálux valgo menor do que 15º (grupo controle). Foram medidas as distâncias da cabeça do primeiro metatarso e do sesamoide lateral ao eixo do segundo metatarso. Posteriormente, forammedidos os coeficientes dessas distâncias pelo comprimento do segundo metatarso, a fim de se ajustarem aos diferentes tamanhos de pés. Resultados Tanto a medida absoluta quanto a medida relativa da cabeça do primeiro metatarso ao segundo metatarso foram significativamente diferentes nos dois grupos, tiveram correlação positiva com os ângulos de hálux valgo e intermetatarsal. Contudo, nem a distância absoluta nem a relativa do sesamoide lateral ao segundo metatarso foram diferentes nos dois grupos, bem como não se correlacionaram com os ângulos de hálux valgo e inter-metatarsal. Conclusão Apesar do desvio medial do primeiro metatarso no hálux valgo, o sesamoide mantém sua relação com o segundo metatarso no plano transverso. Esse aparente deslocamento lateral pode levar a interpretação equivocada dessas radiografias. Tal fato é de suma importância no pré-, peri- e pós-operatório dos pacientes com hálux valgo.


Assuntos
Humanos , Masculino , Feminino , Adolescente , Adulto , Ossos do Metatarso , Hallux Valgus , Radiografia , Análise Estatística
13.
Physiol Behav ; 204: 234-240, 2019 05 15.
Artigo em Inglês | MEDLINE | ID: mdl-30826388

RESUMO

Interoception has been shown to influence self-regulation of effort and perceived exertion during exercise. However, whether interoceptive accuracy influences submaximal and maximal exercise performance, as well as psychophysiological responses to it, remains elusive. We assessed poor (n = 15) and good (n = 17) heartbeat perceivers young men accordingly with their interoceptive accuracy. Heart rate variability (HRV) and blood pressure were measured at rest, and peak power, ratings of perceived exertion (RPE), and HR during a maximal incremental test in a bicycle ergometer. Results: At rest, HR, diastolic and mean blood pressure was lower, and inter-beat intervals were longer for good heartbeat perceivers, with no difference in HRV. During exercise, good and poor heartbeat perceivers exhibited the same submaximal and maximal power, HR, RPE at submaximal intensity, and physical fitness. Interoceptive accuracy does not influence cardiac autonomic modulation perceptual responses and performance at submaximal and maximal intensities during maximal incremental exercise.

14.
Gigascience ; 8(4)2019 04 01.
Artigo em Inglês | MEDLINE | ID: mdl-30715293

RESUMO

BACKGROUND: The selection of bioengineering platform strains and engineering strategies to improve the stress resistance of Saccharomyces cerevisiae remains a pressing need in bio-based chemical production. Thus, a systematic effort to exploit genotypic and phenotypic diversity to boost yeast's industrial value is still urgently needed. RESULTS: We analyzed 5,400 growth curves obtained from 36 S. cerevisiae strains and comprehensively profiled their resistances against 13 industrially relevant stresses. We observed that bioethanol and brewing strains exhibit higher resistance against acidic conditions; however, plant isolates tend to have a wider range of resistance, which may be associated with their metabolome and fluxome signatures in the tricarboxylic acid cycle and fatty acid metabolism. By deep genomic sequencing, we found that industrial strains have more genomic duplications especially affecting transcription factors, showing that they result from disparate evolutionary paths in comparison with the environmental strains, which have more indels, gene deletions, and strain-specific genes. Genome-wide association studies coupled with protein-protein interaction networks uncovered novel genetic determinants of stress resistances. CONCLUSIONS: These resistance-related engineering targets and strain rankings provide a valuable source for engineering significantly improved industrial platform strains.


Assuntos
Estudo de Associação Genômica Ampla , Genômica , Metabolômica , Fenótipo , Saccharomyces cerevisiae/genética , Saccharomyces cerevisiae/metabolismo , Adaptação Biológica , Biologia Computacional , Variação Genética , Estudo de Associação Genômica Ampla/métodos , Genômica/métodos , Metaboloma , Metabolômica/métodos , Filogenia , Saccharomyces cerevisiae/classificação , Estresse Fisiológico
15.
Mol Cell Endocrinol ; 486: 1-10, 2019 04 15.
Artigo em Inglês | MEDLINE | ID: mdl-30753853

RESUMO

This study aimed to analyze galectin-3 importance in endometriotic lesions development and the effect of recombinant Gal-3 carbohydrate recognition domain (Gal3C) in experimental endometriosis treatment. Experimental endometriosis was induced in WT and Gal-3-/- mice. Initially developed lesions were macroscopically and histologically analyzed, including immunohistochemical analysis. Then, WT mice were treated with Gal3C for 15 days. Gal-3 deficiency and Gal3C treatment significantly impaired endometriosis development. A significant decrease in lesions implantation and size, VEGF and VEGFR-2 expression, vascular density and macrophage distribution were observed in Gal-3 absence or inhibition. A greater presence of iNOS positive cells was observed in knockout mice lesions, while the presence of Arginase positive cells was higher in the WT animal lesions. In addition, COX-2 and TGFb1 were reduced by Gal3C treatment. Data showed here indicate a relevant role of Gal-3 in endometriosis development and highlight a target of endometriosis treatment using Gal-3 inhibitor.


Assuntos
Endometriose/tratamento farmacológico , Endometriose/metabolismo , Galectina 3/metabolismo , Terapia de Alvo Molecular , Animais , Biomarcadores/metabolismo , Endométrio/efeitos dos fármacos , Endométrio/patologia , Feminino , Galectina 3/química , Inflamação/patologia , Macrófagos/efeitos dos fármacos , Macrófagos/metabolismo , Camundongos Endogâmicos BALB C , Camundongos Knockout , Neovascularização Patológica/tratamento farmacológico , Domínios Proteicos , Proteínas Recombinantes/química , Proteínas Recombinantes/farmacologia , Proteínas Recombinantes/uso terapêutico , Fator A de Crescimento do Endotélio Vascular/metabolismo , Receptor 2 de Fatores de Crescimento do Endotélio Vascular/metabolismo
16.
Brain Stimul ; 12(3): 593-605, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30630690

RESUMO

BACKGROUND: Transcranial direct current stimulation (tDCS) has been used to improve exercise performance, though the protocols used, and results found are mixed. OBJECTIVE: We aimed to analyze the effect of tDCS on improving exercise performance. METHODS: A systematic search was performed on the following databases, until December 2017: PubMed/MEDLINE, Embase, Web of Science, SCOPUS, and SportDiscus. Full-text articles that used tDCS for exercise performance improvement in adults were included. We compared the effect of anodal (anode near nominal target) and cathodal (cathode near nominal target) tDCS to a sham/control condition on the outcome measure (performance in isometric, isokinetic or dynamic strength exercise and whole-body exercise). RESULTS: 22 studies (393 participants) were included in the qualitative synthesis and 11 studies (236 participants) in the meta-analysis. The primary motor cortex (M1) was the main nominal tDCS target (n = 16; 72.5%). A significant effect favoring anodal tDCS (a-tDCS) applied before exercise over M1 was found on cycling time to exhaustion (mean difference = 93.41 s; 95%CI = 27.39 s-159.43 s) but this result was strongly influenced by one study (weight = 84%), no effect was found for cathodal tDCS (c-tDCS). No significant effect was found for a-tDCS applied on M1 before or during exercise on isometric muscle strength of the upper or lower limbs. Studies regarding a-tDCS over M1 on isokinetic muscle strength presented mixed results. Individual results of studies using a-tDCS applied over the prefrontal and motor cortices either before or during dynamic muscle strength testing showed positive results, but performing meta-analysis was not possible. CONCLUSION: For the protocols tested, a-tDCS but not c-tDCS vs. sham over M1 improved exercise performance in cycling only. However, this result was driven by a single study, which when removed was no longer significant. Further well-controlled studies with larger sample sizes and broader exploration of the tDCS montages and doses are warranted.


Assuntos
Exercício , Estimulação Transcraniana por Corrente Contínua , Desempenho Atlético , Humanos , Córtex Motor/fisiologia
17.
Rev. pesqui. cuid. fundam. (Online) ; 11(1): 205-210, jan.-mar. 2019. tab., graf.
Artigo em Inglês, Português | LILACS, BDENF - Enfermagem | ID: biblio-968494

RESUMO

Objetivos: Verificar el nivel de estrés en los enfermeros que actúan en unidad de terapia intensiva, e identificar las actividades del trabajo que son más estresantes. Métodos: Estudio cuantitativo, exploratorio y descriptivo, realizado en un Hospital Universitario de la ciudad de Rio de Janeiro. Los participantes fueron 25 enfermeros que prestan asistencia directa a los pacientes críticos en la unidad de terapia intensiva. El instrumento utilizado en la medición fue la Escala Bianchi de Stress. Resultados: El análisis de los 51 ítems relacionados con las actividades de trabajo resultó en un nivel bajo de estrés, entre los profesionales de enfermería. El análisis de los dominios demostró nivel medio de estrés referente a las condiciones de trabajo para el desempeño del enfermero y asistencia de enfermería prestada al paciente. Conclusión: Se concluye que las condiciones de trabajo contribuyen a un mayor nivel de estrés. Se hace necesaria la realización de nuevas investigaciones acerca de las condiciones de trabajo y sus relaciones con el estrés


Objectives: The study's purpose has been to verify the stress level of nurses who work in an intensive care unit, and also to identify working activities that are more stressful. Methods: It is a descriptive-exploratory study with a quantitative approach, which was performed at a University Hospital from the Rio de Janeiro city. The study participants were 25 nurses who provide direct care to critically ill patients in the intensive care unit. The instrument used in the measurement was the Bianchi Stress Scale. Results: The analysis of 51 items related to work activities resulted in a low level of stress among nursing professionals. The analysis of the domains showed middle stress levels related to the nurse's working conditions and the nursing care provided to patients. Conclusion: Therefore, working conditions contribute to a higher level of stress. It is necessary to carry out new research on working conditions and their relations with stress


Objetivos: Verificar o nível de estresse nos enfermeiros que atuam em unidade de terapia intensiva e identificar as atividades do trabalho que são mais estressantes.Método:Estudo quantitativo, exploratório e descritivo, realizado em um Hospital Universitário da Cidade do Rio de Janeiro. Os participantes foram 25 enfermeiros que prestam assistência direta aos pacientes críticos na unidade de terapia intensiva. O instrumento utilizado na mensuração foi a Escala Bianchi de Stress. Resultados: A análise dos 51 itens relacionados às atividades de trabalho resultou em um nível baixo de estresse entre os profissionais de enfermagem. A análise dos domínios demonstrou nível médio de estresse referente as condições de trabalho para o desempenho do enfermeiro e assistência de enfermagem prestada ao paciente. Conclusão: Conclui-se que as condições de trabalho contribuem para um maior nível de estresse. Faz se necessária realização de novas pesquisas acerca das condições de trabalho e suas relações com o estresse


Assuntos
Humanos , Masculino , Feminino , Adulto , Condições de Trabalho , Saúde do Trabalhador , Estresse Ocupacional , Unidades de Terapia Intensiva , Internato não Médico
18.
Eur J Sport Sci ; 19(2): 199-207, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30016192

RESUMO

OBJECTIVE: To analyse the effect of resistance training (RT) frequency on muscle mass, appendicular lean soft tissue, insulin-like growth factor 1 (IGF-1), testosterone, and their changes with detraining in older women. METHODS: Forty-five physically independent older women (≥ 60 years) were randomly assigned to perform RT either two (G2X, n = 21) or three times/week (G3X, n = 24), during 12 weeks (8 exercises, 1 set of 10-15 repetition maximum). Muscle mass and appendicular lean soft tissue, IGF-1, testosterone, and dietary intake were measured at pre-training, post-training, and after detraining (12 weeks). RESULTS: Muscle mass and appendicular lean soft tissue significantly increased post-training (G2X = +5.5% and G3X = +5.8%, P < .0001) with no differences between groups, and gains were retained after detraining (G2X = 100% and G3X = 99%, P < .0001). IGF-1 and dietary intake did not change for the groups during the study. Testosterone did not change post-training but significantly decreased after detraining (G2X = -21% and G3X = -50%, P < .0001). CONCLUSION: We conclude that lower RT frequency is as effective as higher frequency to improve muscle mass and appendicular lean soft tissue, and to maintain testosterone and IGF-1. Additionally, detraining may reduce testosterone regardless of RT frequency. These results are specifically for community-dwelling older women and may not be generalized to other populations.


Assuntos
Composição Corporal , Fator de Crescimento Insulin-Like I/análise , Músculo Esquelético/fisiologia , Treinamento de Resistência/métodos , Testosterona/sangue , Idoso , Feminino , Humanos , Pessoa de Meia-Idade
19.
Percept Mot Skills ; 126(1): 119-142, 2019 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-30463479

RESUMO

We assessed the short-term effects of varying the volume of high-intensity interval training (HIIT) on psychological and physiological responses of 23 healthy adult males ( M = 21 years; M peak oxygen uptake [VO2peak] = 47.2 ml·kg-1·min-1). Participants were randomly assigned to low- and very-low-volume HIIT groups and engaged in nine supervised exercise sessions over three weeks. The low-volume HIIT group performed 8-12 60-second work bouts on a cycle ergometer at the peak power output achieved during the incremental test, interspersed by 75 seconds of low-intensity active recovery. The very-low-volume HIIT performed 4-6 work bouts with the same intensity, duration, and rest intervals. During training, participants' ratings of perceived exertion (Borg Category Ratio-10 scale) and their affective responses (Feeling Scale -5/+5) during the last 15 seconds of each work bout were recorded. Physiological data were VO2peak, endurance, and anaerobic performance before and after the intervention. Throughout training, participants in the very-low-volume group (relative to the low-volume group) reported lower ratings of perceived exertion in Week 1 ( M = 4.1 vs. M = 6.3; p < .01) and Week 3 ( M = 4.0 vs. M = 6.2; p < .01), and higher affective response in these same two weeks (Week 1: M = 1.9 vs. M = 0.3; p = .04; Week 3: M = 2.1 vs. M = 0.9; p = .06). Regarding physical fitness, Wingate peak power increased significantly after training in the very-low-volume HIIT group ( M = 1,049 W vs. M = 1,222 W; p < .05), but not in the low-volume HIIT group ( M = 1,050 W vs. M = 1,076 W). No significant change was found after training in physiological variables of peak power output, VO2peak, and endurance performance. In summary, in this short-term training period, the very-low-volume HIIT enhanced anaerobic capacity and was perceived as less strenuous and more pleasurable than low-volume HIIT.


Assuntos
Afeto/fisiologia , Treinamento Intervalado de Alta Intensidade/métodos , Treinamento Intervalado de Alta Intensidade/psicologia , Consumo de Oxigênio/fisiologia , Resistência Física/fisiologia , Esforço Físico/fisiologia , Adulto , Limiar Anaeróbio/fisiologia , Humanos , Masculino , Adulto Jovem
20.
Mol Brain ; 12(1): 117, 2019 Dec 30.
Artigo em Inglês | MEDLINE | ID: mdl-31888677

RESUMO

Clinical and preclinical studies have shown that patients with Diabetic Neuropathy Pain (DNP) present with increased tumor necrosis factor alpha (TNF-α) serum concentration, whereas studies with diabetic animals have shown that TNF-α induces an increase in NaV1.7 sodium channel expression. This is expected to result in sensitization of nociceptor neuron terminals, and therefore the development of DNP. For further study of this mechanism, dissociated dorsal root ganglion (DRG) neurons were exposed to TNF-α for 6 h, at a concentration equivalent to that measured in STZ-induced diabetic rats that developed hyperalgesia. Tetrodotoxin sensitive (TTXs), resistant (TTXr) and total sodium current was studied in these DRG neurons. Total sodium current was also studied in DRG neurons expressing the collapsin response mediator protein 2 (CRMP2) SUMO-incompetent mutant protein (CRMP2-K374A), which causes a significant reduction in NaV1.7 membrane cell expression levels. Our results show that TNF-α exposure increased the density of the total, TTXs and TTXr sodium current in DRG neurons. Furthermore, TNF-α shifted the steady state activation and inactivation curves of the total and TTXs sodium current. DRG neurons expressing the CRMP2-K374A mutant also exhibited total sodium current increases after exposure to TNF-α, indicating that these effects were independent of SUMOylation of CRMP2. In conclusion, TNF-α sensitizes DRG neurons via augmentation of whole cell sodium current. This may underlie the pronociceptive effects of TNF-α and suggests a molecular mechanism responsible for pain hypersensitivity in diabetic neuropathy patients.

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