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1.
Arq Bras Cardiol ; 109(3 Supl 1): 1-104, 2017 Jan-Feb.
Artigo em Inglês, Português | MEDLINE | ID: mdl-29044300
2.
Arq. bras. cardiol ; 109(3,supl.1): 1-104, Sept. 2017. tab, graf
Artigo em Inglês | LILACS-Express | ID: biblio-887936
5.
Clinics (Sao Paulo) ; 64(1): 5-10, 2009.
Artigo em Inglês | MEDLINE | ID: mdl-19142544

RESUMO

OBJECTIVE: Evaluate whether exhaled nitric oxide may serve as a marker of intraoperative bronchospasm. INTRODUCTION: Intraoperative bronchospasm remains a challenging event during anesthesia. Previous studies in asthmatic patients suggest that exhaled nitric oxide may represent a noninvasive measure of airway inflammation. METHODS: A total of 146,358 anesthesia information forms, which were received during the period from 1999 to 2004, were reviewed. Bronchospasm was registered on 863 forms. From those, three groups were identified: 9 non-asthmatic patients (Bronchospasm group), 12 asthmatics (Asthma group) and 10 subjects with no previous airway disease or symptoms (Control group). All subjects were submitted to exhaled nitric oxide measurements (parts/billion), spirometry and the induced sputum test. The data was compared by ANOVA followed by the Tukey test and Kruskal-Wallis followed by Dunn's test. RESULTS: The normal lung function test results for the Bronchospasm group were different from those of the asthma group (p <0.05). The median percentage of eosinophils in induced sputum was higher for the Asthma [2.46 (0.45-6.83)] compared with either the Bronchospasm [0.55 (0-1.26)] or the Control group [0.0 (0)] (p <0.05); exhaled nitric oxide followed a similar pattern for the Asthma [81.55 (57.6-86.85)], Bronchospasm [46.2 (42.0 -62.6] and Control group [18.7 (16.0-24.7)] (p< 0.05). CONCLUSIONS: Non-asthmatic patients with intraoperative bronchospasm detected during anesthesia and endotracheal intubation showed increased expired nitric oxide.


Assuntos
Anestesia/efeitos adversos , Espasmo Brônquico/induzido quimicamente , Expiração/efeitos dos fármacos , Mediadores da Inflamação/análise , Complicações Intraoperatórias/induzido quimicamente , Óxido Nítrico/análise , Adolescente , Adulto , Análise de Variância , Anestesia por Inalação , Asma/diagnóstico , Espasmo Brônquico/diagnóstico , Broncodilatadores/efeitos adversos , Broncodilatadores/análise , Estudos de Casos e Controles , Eosinófilos , Feminino , Humanos , Mediadores da Inflamação/efeitos adversos , Masculino , Pessoa de Meia-Idade , Óxido Nítrico/efeitos adversos , Espirometria , Escarro/química , Adulto Jovem
6.
Clinics ; 64(1): 5-10, 2009. ilus, tab
Artigo em Inglês | LILACS | ID: lil-501880

RESUMO

OBJECTIVE: Evaluate whether exhaled nitric oxide may serve as a marker of intraoperative bronchospasm. INTRODUCTION: Intraoperative bronchospasm remains a challenging event during anesthesia. Previous studies in asthmatic patients suggest that exhaled nitric oxide may represent a noninvasive measure of airway inflammation. METHODS: A total of 146,358 anesthesia information forms, which were received during the period from 1999 to 2004, were reviewed. Bronchospasm was registered on 863 forms. From those, three groups were identified: 9 non-asthmatic patients (Bronchospasm group), 12 asthmatics (Asthma group) and 10 subjects with no previous airway disease or symptoms (Control group). All subjects were submitted to exhaled nitric oxide measurements (parts/billion), spirometry and the induced sputum test. The data was compared by ANOVA followed by the Tukey test and Kruskal-Wallis followed by Dunn's test. RESULTS: The normal lung function test results for the Bronchospasm group were different from those of the asthma group (p <0.05). The median percentage of eosinophils in induced sputum was higher for the Asthma [2.46 (0.45-6.83)] compared with either the Bronchospasm [0.55 (0-1.26)] or the Control group [0.0 (0)] (p <0.05); exhaled nitric oxide followed a similar pattern for the Asthma [81.55 (57.6-86.85)], Bronchospasm [46.2 (42.0 -62.6] and Control group [18.7 (16.0-24.7)] (p< 0.05). CONCLUSIONS: Non-asthmatic patients with intraoperative bronchospasm detected during anesthesia and endotracheal intubation showed increased expired nitric oxide.


Assuntos
Adolescente , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Adulto Jovem , Anestesia/efeitos adversos , Espasmo Brônquico/induzido quimicamente , Expiração/efeitos dos fármacos , Mediadores da Inflamação/análise , Complicações Intraoperatórias/induzido quimicamente , Óxido Nítrico/análise , Análise de Variância , Anestesia por Inalação , Asma/diagnóstico , Espasmo Brônquico/diagnóstico , Broncodilatadores/efeitos adversos , Broncodilatadores/análise , Estudos de Casos e Controles , Eosinófilos , Mediadores da Inflamação/efeitos adversos , Óxido Nítrico/efeitos adversos , Espirometria , Escarro/química , Adulto Jovem
7.
J Vasc Surg ; 39(5): 967-75; discussion 975-6, 2004 May.
Artigo em Inglês | MEDLINE | ID: mdl-15111846

RESUMO

OBJECTIVES: This prospective, randomized, placebo-controlled, double-blind clinical trial was performed to analyze the effect of atorvastatin compared with placebo on the occurrence of a 6-month composite of cardiovascular events after vascular surgery. Cardiovascular complications are the most important cause of perioperative morbidity and mortality among patients undergoing vascular surgery. Statin therapy may reduce perioperative cardiac events through stabilization of coronary plaques. METHODS: One hundred patients were randomly assigned to receive 20 mg atorvastatin or placebo once a day for 45 days, irrespective of their serum cholesterol concentration. Vascular surgery was performed on average 30 days after randomization, and patients were prospectively followed up over 6 months. The cardiovascular events studied were death from cardiac cause, nonfatal myocardial infarction, unstable angina, and stroke. RESULTS: Fifty patients received atorvastatin, and 50 received placebo. During the 6-month follow-up primary end points occurred in 17 patients, 4 in the atorvastatin group and 13 in the placebo group. The incidence of cardiac events was more than three times higher with placebo (26.0%) compared with atorvastatin (8.0%; P =.031). The risk for an event was compared between the groups with the Kaplan-Meier method, as event-free survival after vascular surgery. Patients given atorvastatin exhibited a significant decrease in the rate of cardiac events, compared with the placebo group, within 6 months after vascular surgery (P =.018). CONCLUSION: Short-term treatment with atorvastatin significantly reduces the incidence of major adverse cardiovascular events after vascular surgery.


Assuntos
Doenças Cardiovasculares/prevenção & controle , Ácidos Heptanoicos/uso terapêutico , Inibidores de Hidroximetilglutaril-CoA Redutases/uso terapêutico , Complicações Pós-Operatórias/prevenção & controle , Pirróis/uso terapêutico , Procedimentos Cirúrgicos Vasculares , Idoso , Atorvastatina , LDL-Colesterol/sangue , Método Duplo-Cego , Feminino , Seguimentos , Humanos , Incidência , Masculino , Cooperação do Paciente , Estudos Prospectivos , Fatores de Risco , Fatores de Tempo
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