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1.
MethodsX ; 7: 101135, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33299802

RESUMO

Cell migration is the process by which cells move through tissues, and it is crucial to carry out a wide variety of physiological and pathological processes. The study methods to evaluate cell migration are very useful tools for biomedical research. Among these methods, the wound and healing assay is one of the simplest, most economical and is widely used in research. However, one of its disadvantages is that the width and shape of the wound can vary among experimental samples since the scraping is carried out manually, representing a difficult variable to control. In the present article a variant of the razor scrape assay is addressed, which eliminates this variation in the width of the wound, thus facilitating the measurement and comparison using the total area of cell migration.•A method that can be carried out under standard culture conditions.•Avoids the disadvantage of variation in width and shape of the wound.•It constitutes a simple, cheap option and multiple advantages over the traditional method.

2.
Rev. peru. med. exp. salud publica ; 32(4): 766-776, oct.-dic. 2015. ilus, tab
Artigo em Espanhol | LILACS, LIPECS, INS-PERU | ID: lil-790790

RESUMO

De acuerdo con la Organización Mundial de la Salud, cada año fallecen 3,4 millones de personas adultas por consecuencias del sobrepeso u obesidad. Personas con un índice de masa corporal superior a 30, presentan cierto aumento en la incidencia de algunas enfermedades entre las que se encuentran algunos tipos de cánceres. En esta revisión de tipo narrativa se aborda el papel que tiene el tejido adiposo como modulador del sistema endocrino y facilitador de la inflamación crónica subclínica. Se discute cómo la obesidad puede producir un microambiente favorable para el desarrollo de tumores, principalmente por el incremento del estrés oxidativo y en las concentraciones de diversas hormonas como la leptina, la insulina y la prolactina. Se concluye que, en conjunto, estos factores incrementan la probabilidad de desarrollar cáncer...


According to the World Health Organization, every year about 3.4 million adults die of consequences related to overweight or obesity. People with a Body Mass Index above 30 are more likely to express certain diseases, including some types of cancer. In this narrative review, we assess the role of adipose tissue as a modulator of the endocrine system and facilitator of chronic subclinical inflammation. We discuss how obesity can induce a suitable micro environment for the development of tumors, mainly by enhancing the levels of oxidative stress and the concentrations of hormones such as leptin, insulin and prolactin. We conclude that all together, these factors increase the probability of cancer development...


Assuntos
Humanos , Estresse Oxidativo , Fatores de Risco , Hormônios , Inflamação , Neoplasias , Obesidade
3.
Rev Peru Med Exp Salud Publica ; 32(4): 766-76, 2015 Oct.
Artigo em Espanhol | MEDLINE | ID: mdl-26732928

RESUMO

According to the World Health Organization, every year about 3.4 million adults die of consequences related to overweight or obesity. People with a Body Mass Index above 30 are more likely to express certain diseases, including some types of cancer. In this narrative review, we assess the role of adipose tissue as a modulator of the endocrine system and facilitator of chronic subclinical inflammation. We discuss how obesity can induce a suitable micro environment for the development of tumors, mainly by enhancing the levels of oxidative stress and the concentrations of hormones such as leptin, insulin and prolactin. We conclude that all together, these factors increase the probability of cancer development.


Assuntos
Neoplasias/epidemiologia , Obesidade , Tecido Adiposo , Humanos , Leptina , Fatores de Risco
4.
Clin Interv Aging ; 6: 53-9, 2011.
Artigo em Inglês | MEDLINE | ID: mdl-21472092

RESUMO

Alzheimer's disease (AD) is the most common neurodegenerative disorder, originating sporadically in the population aged over 65 years, and advanced age is the principal risk factor leading to AD development. In spite of the large amount of research going on around the globe and all the information now available about AD, there is still no origin or triggering process known so far. Drugs approved for the treatment of AD include tacrine, donepezil, rivastigmine, galantamine, and memantine. These may delay or slow down the degenerative process for a while, but they can neither stop nor reverse its progression. Because that this might be due to a lack of effect of these drugs on degenerating neurons, even when they are able to potentiate the brain in nondegenerative conditions, we propose here an alternative therapy consisting of initial repair of neuronal membranes followed by conventional drug therapies. The rehabilitation of neurons in a degeneration process would enable the drugs to act more effectively on them and improve the effects of treatment in AD patients.


Assuntos
Doença de Alzheimer/tratamento farmacológico , Doença de Alzheimer/reabilitação , Nootrópicos/uso terapêutico , Fitoterapia , Vitaminas/uso terapêutico , Idoso , Idoso de 80 Anos ou mais , Criança , Feminino , Humanos , Degeneração Neural/tratamento farmacológico , Degeneração Neural/reabilitação
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