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1.
Medicine (Baltimore) ; 100(35): e27144, 2021 Sep 03.
Artigo em Inglês | MEDLINE | ID: mdl-34477170

RESUMO

ABSTRACT: This study aimed to evaluate the diagnostic performance of diffusion kurtosis imaging (DKI) and prostate-specific antigen (PSA) biomarkers in differentiating prostate cancer (PCa) and benign prostatic hyperplasia (BPH).A total of 43 cases of prostate diseases verified by pathology were enrolled in the present study. These cases were assigned to the BPH group (n = 20, 68.85±10.81 years old) and PCa group (n = 23, 74.13 ±â€Š7.37 years old). All patients underwent routine prostate magnetic resonance imaging and DKI examinations, and the mean diffusivity (MD), mean kurtosis (MK), and fractional anisotropy (FA) values were calculated. Three serum indicators (PSA, free PSA [fPSA], and f/t PSA) were collected. We used univariate logistic regression to analyze the above quantitative parameters between the 2 groups, and the independent factors were further incorporated into the multivariate logistic regression model. The area under the receiver operating characteristic curve (AUC) was used to evaluate the diagnostic efficacy of the single indicator and combined model.The difference in PSA, f/t PSA, MK, and FA between PCa and BPH was statistically significant (P < .05). The AUC for the combined model (f/t PSA, MK, and FA) of 0.972 (95% confidence interval [CI]: 0.928, 1.000) was higher than the AUC of 0.902 (95% CI: 0.801, 1.000) for f/t PSA, 0.833 (95% CI: 0.707, 0.958) for MK, and 0.807 (95% CI: 0.679, 0.934) for FA.The MK and FA values for DKI and f/t PSA effectively identify PCa and BPH, compared to the PSA indicators. Combining DKI and PSA derivatives can further improve the diagnosis efficiency and might help in the clinical setting.


Assuntos
Imageamento por Ressonância Magnética/métodos , Antígeno Prostático Específico/sangue , Hiperplasia Prostática/diagnóstico por imagem , Neoplasias da Próstata/diagnóstico por imagem , Idoso , Idoso de 80 Anos ou mais , Diagnóstico Diferencial , Humanos , Masculino , Pessoa de Meia-Idade , Hiperplasia Prostática/sangue , Neoplasias da Próstata/sangue , Estudos Retrospectivos
2.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi ; 38(9): 845-848, 2021 Sep 10.
Artigo em Chinês | MEDLINE | ID: mdl-34487527

RESUMO

OBJECTIVE: To assess the application value of mapping allele with resolved carrier status (MaReCs) technique for preimplantation genetic testing (PGT). METHODS: The characteristics of MaReCs for PGT and outcome of patients were retrospectively analyzed. RESULTS: Compared with those who could not use the technique, carriers who have used the MaReCs technique were younger, had significantly higher level of anti-Mullerian hormone, more antral follicles, occytes, mature occytes, biopsied embryos and euploid embryos, and lower risks for de novo chromosomal abnormality (P<0.05). It was necessary for couples with fewer oocytes, mature oocytes and balstocyst to preserve discarded embryos to facilitate the test. Carriers who have used the MaReCs technique had higher clinical pregnancy rate and abortion rate compared with those undergoing routine PGT, albeit no significant difference was found between the two groups (P> 0.05). Carriers undergoing MaReCs test could preferentially select embryos with normal chromosome structures for the transfer. CONCLUSION: Application of MaReCs has a prerequisite for having a minimum number of occytes and biopsied embryos and using discarded embryos sometimes. MaReCs is efficient for the detection of carrier status of embryos and attaining higher rate of pregnancy and live birth, which can significantly improve the outcome for couples carrying chromosomal translocations.


Assuntos
Diagnóstico Pré-Implantação , Translocação Genética , Alelos , Aneuploidia , Blastocisto , Feminino , Fertilização In Vitro , Testes Genéticos , Humanos , Gravidez , Estudos Retrospectivos
3.
Molecules ; 26(5)2021 Feb 25.
Artigo em Inglês | MEDLINE | ID: mdl-33669144

RESUMO

A broadband visible light-absorbing [70]fullerene-BODIPY-triphenylamine triad (C70-B-T) has been synthesized and applied as a heavy atom-free organic triplet photosensitizer for photooxidation. By attaching two triphenylmethyl amine units (TPAs) to the π-core of BODIPY via ethynyl linkers, the absorption range of the antenna is extended to 700 nm with a peak at 600 nm. Thus, the absorption spectrum of C70-B-T almost covers the entire UV-visible region (270-700 nm). The photophysical processes are investigated by means of steady-state and transient spectroscopies. Upon photoexcitation at 339 nm, an efficient energy transfer (ET) from TPA to BODIPY occurs both in C70-B-T and B-T, resulting in the appearance of the BODIPY emission at 664 nm. Direct or indirect (via ET) excitation of the BODIPY-part of C70-B-T is followed by photoinduced ET from the antenna to C70, thus the singlet excited state of C70 (1C70*) is populated. Subsequently, the triplet excited state of C70 (3C70*) is produced via the intrinsic intersystem crossing of C70. The photooxidation ability of C70-B-T was studied using 1,5-dihydroxy naphthalene (DHN) as a chemical sensor. The photooxidation efficiency of C70-B-T is higher than that of the individual components of C70-1 and B-T, and even higher than that of methylene blue (MB). The photooxidation rate constant of C70-B-T is 1.47 and 1.51 times as that of C70-1 and MB, respectively. The results indicate that the C70-antenna systems can be used as another structure motif for a heavy atom-free organic triplet photosensitizer.


Assuntos
Compostos de Anilina/química , Compostos de Boro/química , Fulerenos/química , Luz , Fármacos Fotossensibilizantes/química , Estrutura Molecular , Oxirredução , Processos Fotoquímicos , Fármacos Fotossensibilizantes/síntese química
4.
Front Psychol ; 10: 1849, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31496969

RESUMO

Humor has been a hot topic for social cognition in recent years. The present study focused on the social attribute of humor and showed different stories to participants, which were divided into four types according to the model of humor style, to explore the underlying neural mechanism of point-to-self aggressive humor and how individual differences modulated it. Measuring the degree of anger and funniness, results suggested that aggressive humor helped us in social communication by reducing the degree of anger. The neural activities showed that bilateral temporal lobes and frontal lobes played a synergistic role in the point-to-self aggressive humor processing, while point-to-self non-aggressive humor was dominant in the left-side brain. Results from the region of interest (ROI) analysis showed that the individual differences of the self-control level and the self-construal level may influence the neural processing of point-to-self aggressive humor by modulating the activated levels and patterns of the right inferior orbital frontal gyrus, the right superior temporal lobe, and the right superior frontal lobe.

5.
J Cancer ; 10(3): 672-681, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30719165

RESUMO

Cervical cancer is the most common and lethal gynaecological tumor. Long noncoding RNAs (lncRNAs) have critical roles in various cancers, including cervical cancer. However, few studies investigated the diagnostic value of lncRNAs for cervical cancer. In this study, we investigated the expression pattern of a recently identified lncRNA GIHCG in cervical cancer tissues, cell lines, and serums by qRT-PCR. Furthermore, we explored the roles of GIHCG in cervical cancer using gain-of-function and loss-of-function assays. Our results revealed that GIHCG is up-regulated in cervical cancer tissues and cell lines compared with adjacent normal tissues and normal cervical epithelial cell line, respectively. Furthermore, serum GIHCG is significantly up-regulated in cervical cancer patients compared with healthy controls. ROC curve analysis revealed that serum GIHCG could accurately discriminate cervical cancer patients from healthy controls. Functionally, we found that overexpression of GIHCG promotes cell proliferation, inhibits cell apoptosis, and promotes cell migration of cervical cancer cells. Conversely, depletion of GIHCG inhibits cell proliferation, induces cell apoptosis, and inhibits cell migration of cervical cancer cells. Mechanistically, we found that GIHCG represses the expression of miR-200b. The expression of miR-200b is inversely correlated with the expression of GIHCG in cervical cancer tissues. Moreover, overexpression of miR-200b attenuates the roles of GIHCG in promoting cervical cancer tumor growth in vivo. In summary, this study demonstrated that GIHCG functions as an oncogene in cervical cancer via repressing miR-200b. This study also suggested that GIHCG may be a non-invasive diagnostic biomarker and a potential therapeutic target for cervical cancer.

6.
Scand J Psychol ; 57(4): 288-91, 2016 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-27153177

RESUMO

Recent research has shown that poverty directly impeded cognitive functions because the poor could be easily distracted by monetary concerns. We argue that this effect may be limited to functions relying on working memory. For functions that rely on proceduralized processes however, monetary concerns elicited by reminding of financial demands would be conducive rather than harmful. Our results supported this hypothesis by showing that participants with lower income reached the learning criterion of the information-integration categorization task faster than their more affluent counterparts after reminding of financial demands.


Assuntos
Aprendizagem , Pobreza/psicologia , Adulto , Comportamento de Escolha , Feminino , Humanos , Masculino , Memória de Curto Prazo , Fatores Socioeconômicos , Adulto Jovem
7.
BMJ Open ; 6(2): e008558, 2016 Feb 11.
Artigo em Inglês | MEDLINE | ID: mdl-26868940

RESUMO

OBJECTIVE: This study was designed to examine the prevalence of unilateral and bilateral diagonal earlobe creases (DELCs) with respect to the diagnosis of coronary heart disease (CHD). METHODS: A total of 558 consecutive participants (402 males and 156 females) aged 36-91 years who underwent coronary angiography were enrolled in this study. The participants were classified as being without a DELC, having a unilateral DELC and having bilateral DELCs; participants with either a unilateral DELC or bilateral DELCs were defined as participants with DELCs. Significant CHD was defined as at least one major vessel with >50% stenosis, and coronary atherosclerosis severity was defined using the Gensini scoring system. RESULTS: In the present study, bilateral DELCs were more frequently among male (p=0.001), CHD (p=0.000), older people (p=0.000) and those with more severe coronary artery atherosclerosis (p=0.000). The results of the multiple regression analyses indicated that DELCs (OR, 4.861; 95% CI 3.093 to 7.642, p=0.000) remained independently associated with a risk of CHD. It was assumed that participants without a DELC have a certain background risk for CHD (OR is assumed to be 1); the results of the multivariate logistic regression indicated that the relative risk of CHD among participants with bilateral DELCs was 5.690 among all participants (OR, 5.690; 95% CI 3.450 to 9.384, p=0.000), 5.436 among male participants (OR, 5.436; 95% CI 2.808 to 10.523, p=0.000) and 7.148 among female participants (OR, 7.148; 95% CI 3.184 to 16.049, p=0.000). Moreover, a positive association between DELC and age (SI=1.21, SIM=1.65, AP =0.132), gender (SI=2.09, SIM=0.81, AP=0.49) and smoking status (SI=1.49, SIM=0.73, AP=0.29) was found, respectively. CONCLUSIONS: The results of the present study indicated that DELCs are a simple and a feasible means of identifying CHD. However, the exact mechanism underlying the relationship between DELCs and CHD warrants further study.


Assuntos
Angiografia Coronária , Doença da Artéria Coronariana/diagnóstico , Orelha Externa/anatomia & histologia , Adulto , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Doença da Artéria Coronariana/diagnóstico por imagem , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Prevalência , Fatores de Risco , Índice de Gravidade de Doença , Fatores Sexuais
8.
Int J Psychophysiol ; 99: 121-4, 2016 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-26620929

RESUMO

Initial exertion of self-control impairs subsequent self-regulatory performance, which is referred to as the ego depletion effect. The current study examined how individual differences in dopamine level, as indexed by eye blink rate (EBR), would moderate ego depletion. An inverted-U-shaped relationship between EBR and subsequent self-regulatory performance was found when participants initially engaged in self-control but such relationship was absent in the control condition where there was no initial exertion, suggesting individuals with a medium dopamine level may be protected from the typical ego depletion effect. These findings are consistent with a cognitive explanation which considers ego depletion as a phenomenon similar to "switch costs" that would be neutralized by factors promoting flexible switching.


Assuntos
Piscadela/fisiologia , Dopamina/fisiologia , Ego , Eletroculografia/métodos , Individualidade , Estimulação Luminosa/métodos , Feminino , Humanos , Masculino , Autoimagem , Adulto Jovem
9.
Cogn Process ; 16 Suppl 1: 443-7, 2015 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-26224276

RESUMO

Subjective time of an event in the sub-second range is often compressed or dilated by the situational context created by preceding and succeeding stimuli. How such context distorts psychological time is still an open question. Here, we pursued this issue by examining whether the perceptual grouping among successive visual stimuli modulates the perceived duration. Using a duration comparison task, we asked observers to judge the relative duration of a target and a comparison item, and estimated the apparent duration of the target from the corresponding psychometric function. The target was temporally flanked by a preceding item and a succeeding item. In different conditions, the target was more similar to either the preceding or the succeeding item. Results showed that perceptual grouping based on similarity modulated perceived duration. Specifically, when the target was grouped with the preceding item, its subjective duration was shorter than when it was grouped with the succeeding item. Interestingly, this pattern was observed when the preceding and target items were kept constant while the succeeding item was manipulated, suggesting that the effect depends, to some degree, on the holistic perceptual grouping rather than on fragmented processes. These results demonstrate that the situational context is an important factor in shaping temporal codes, thus bridging the seemingly independent perceptual feature processes and temporal representation.


Assuntos
Reconhecimento Visual de Modelos/fisiologia , Percepção do Tempo/fisiologia , Adulto , Análise de Variância , Atenção/fisiologia , Feminino , Humanos , Masculino , Estimulação Luminosa , Psicometria , Tempo de Reação/fisiologia , Fatores de Tempo , Adulto Jovem
10.
Front Psychol ; 6: 521, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-25964774

RESUMO

Accumulated evidence has shown that the subjective time in the sub-second range can be altered by different factors; some are related to stimulus features such as luminance contrast and spatial frequency, others are processes like perceptual grouping and contextual modulation. These findings indicate that temporal perception uses neural signals involved in non-temporal feature processes and that perceptual organization plays an important role in shaping the experience of elapsed time. We suggest that the temporal representation of objects can be treated as a feature of objects. This new concept implies that psychological time can serve as a tool to study the principles of neural codes in the perception of objects like "reaction time (RT)." Whereas "RT" usually reflects the state of transient signals crossing decision thresholds, "apparent time" in addition reveals the dynamics of sustained signals, thus providing complementary information of what has been obtained from "RT" studies.

11.
12.
Scand J Psychol ; 56(2): 223-7, 2015 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-25491068

RESUMO

It has been consistently demonstrated that initial exertion of self-control had negative influence on people's performance on subsequent self-control tasks. This phenomenon is referred to as the ego depletion effect. Based on action control theory, the current research investigated whether the ego depletion effect could be moderated by individuals' action versus state orientation. Our results showed that only state-oriented individuals exhibited ego depletion. For individuals with action orientation, however, their performance was not influenced by initial exertion of self-control. The beneficial effect of action orientation against ego depletion in our experiment results from its facilitation for adapting to the depleting task.


Assuntos
Ego , Motivação , Personalidade , Autocontrole , Feminino , Humanos , Masculino , Teoria Psicológica , Análise e Desempenho de Tarefas , Adulto Jovem
13.
J Exp Psychol Gen ; 143(5): 1893-902, 2014 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-25000445

RESUMO

Event timing engages a distributed neural network including cortical and subcortical structures. However, it remains unclear whether the early visual cortex contributes to event timing. Here we showed that the processes of nontemporal visual features such as orientation and spatial location, which are coded by the early visual cortex, contribute to the temporal representation of a visual stimulus. Participants were presented with 2 successive Gabor patches (a prime and a target) with different orientations or spatial locations. The subjective duration of the target was significantly reduced when it was preceded by the prime compared with when presented alone. More important, this duration-compression effect varied systematically as a function of orientation similarity or spatial proximity between the prime and the target and was influenced by how the prime and the target were perceptually grouped. Our results suggest that repetition suppression of neural activity in response to orientation may contribute to the observed duration distortion and that neurons in the early visual cortex with small receptive fields and orientation selectivity may be involved in visual temporal perception. Our findings help to understand the functional role of early visual cortex in event timing in humans.


Assuntos
Orientação/fisiologia , Percepção do Tempo/fisiologia , Córtex Visual/fisiologia , Adulto , Feminino , Humanos , Masculino , Vias Neurais/fisiologia , Adulto Jovem
14.
Cancer Sci ; 105(6): 630-8, 2014 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-24703594

RESUMO

Calpain small subunit 1 (Capn4) plays a key role in tumor migration or invasion. In this study, expression and function of Capn4 was investigated in human nasopharyngeal carcinoma (NPC). Here we report that both mRNA and protein levels of Capn4 were elevated in NPC tissues when compared to normal NP tissues. Similarly, Capn4 was also highly expressed in multiple NPC cell lines, compared to immortalized human nasopharyngeal epithelial cell line NP69. Moreover, expression of Capn4 was significantly correlated with Epstein-Barr virus infection, advanced stages, and lymph node or distant metastasis (P < 0.001). The patients with NPC displaying higher Capn4 had a significantly shorter overall survival (P = 0.002) and progression-free survival (P = 0.003). Furthermore, siRNA knockdown of Capn4 suppressed cell migration and invasion in vitro and in vivo. These events resulted from Capn4 downregulation were associated with reduced expression of matrix metalloproteinase 2 (MMP2), Snail, and Vimentin. Finally, we demonstrated that Capn4 upregulated MMP2 via nuclear factor-κB (NF-κB) activation, manifested by increased phosphorylation of p65, a subunit of NF-κB. Together, these findings argue a novel function of Capn4 in invasion and metastasis of NPC, and thereby suggest that Capn4 may represent an independent prognostic factor and a potential therapeutic target in NPC.


Assuntos
Biomarcadores Tumorais/biossíntese , Calpaína/biossíntese , Metaloproteinase 2 da Matriz/biossíntese , Neoplasias Nasofaríngeas/patologia , Fator de Transcrição RelA/metabolismo , Animais , Biomarcadores Tumorais/genética , Caderinas/biossíntese , Calpaína/genética , Carcinoma , Linhagem Celular Tumoral , Movimento Celular/genética , Intervalo Livre de Doença , Ativação Enzimática , Infecções por Vírus Epstein-Barr/metabolismo , Feminino , Adesões Focais/metabolismo , Regulação Neoplásica da Expressão Gênica , Humanos , Masculino , Camundongos , Camundongos Endogâmicos BALB C , Camundongos Nus , Pessoa de Meia-Idade , Carcinoma Nasofaríngeo , Neoplasias Nasofaríngeas/mortalidade , Invasividade Neoplásica , Metástase Neoplásica , Fosforilação , Interferência de RNA , RNA Mensageiro/biossíntese , RNA Interferente Pequeno , Fatores de Transcrição da Família Snail , Fatores de Transcrição/biossíntese , Vimentina/biossíntese
15.
Neurosci Lett ; 564: 32-6, 2014 Apr 03.
Artigo em Inglês | MEDLINE | ID: mdl-24513232

RESUMO

The mind-reading hypothesis of humor and the inner eye theory of laughter both claim that readers' mentalizing about characters in jokes is essential for perceiving humor. On the basis of this notion, we hypothesized that point-to-other verbal jokes (in which one character said funny things about the other character) induced more theory of mind (ToM) processing than point-to-self verbal jokes (in which one character said funny things about him/herself to the other character). Our hypothesis was tested by comparing percent signal changes of these two conditions in six core components of the ToM neural network. A whole-brain analysis was also conducted. Results from both the region of interest (ROI) analysis and the whole-brain analysis show that theory of mind network is more activated when subjects read point-to-other jokes than when they read point-to-self jokes. Moreover, the whole-brain results provide support for the viewpoint that the right hemisphere, especially the right frontal lobe, is important in ToM and humor processing.


Assuntos
Encéfalo/fisiologia , Rede Nervosa/fisiologia , Teoria da Mente/fisiologia , Senso de Humor e Humor como Assunto , Adulto , Mapeamento Encefálico , Feminino , Humanos , Imageamento por Ressonância Magnética , Masculino , Adulto Jovem
16.
Zhongguo Zhong Xi Yi Jie He Za Zhi ; 33(9): 1191-5, 2013 Sep.
Artigo em Chinês | MEDLINE | ID: mdl-24273971

RESUMO

OBJECTIVE: To observe the efficacy of Danzhi Xiaoyao Pill (DXP) in anovulation infertility patients with polycystic ovary syndrome (PCOS) of pathogenic fire derived from stagnation of Gan-qi (PFDSG) complicated insulin resistance (IR). METHODS: Sixty PCOS patients were randomly assigned to two group, the integrative medical treatment group (Group A) and the Western medical treatment group (Group B), 30 cases in each group. All patients took Metformin and Diane-35. Those in Group A took DXP additionally. The therapeutic course for all was 3 menstrual cycles. After treatment the ovulation was induced by oral administration of letrozole or injection of menotropins (HMG). The therapeutic efficacy was compared between the two groups. RESULTS: The levels of insulin, luteinizing hormone, and testosterone were obviously lower after treatment than before treatment in the two groups (P < 0.05). There was no statistical difference between the two groups after treatment. There was no statistical difference in body mass index (BMI) between the two groups before and after treatment (P > 0.05). Better effects were obtained in Group A in improving symptoms such as agitation and irritability, fullness in the chest and hypochondrium, swollen pain in the breast before menstruation, bitter and dry mouth, oligomenorrhea, abnormal color and amount of menstruation, and pulse and tongue (P < 0.05, P < 0.01). The ovulation rate was 86.1% (93/108 cases) in Group A, obviously higher than that in Group B (65.5%, 74/113 cases). The clinical pregnancy rate was 60.0% (18/30 cases) in Group A, obviously higher than that in Group B (36.7%, 11/30 cases), showing statistical difference (P < 0.05). CONCLUSIONS: DXP could improve the ovulation rate and the pregnancy rate in anovulation infertility patients with PCOS complicated IR. It also could significantly improve Chinese medical syndromes, showing obvious advantages over using Western medicine alone.


Assuntos
Medicamentos de Ervas Chinesas/uso terapêutico , Fitoterapia/métodos , Síndrome do Ovário Policístico/tratamento farmacológico , Adulto , Feminino , Humanos , Medicina Tradicional Chinesa , Indução da Ovulação , Síndrome do Ovário Policístico/diagnóstico , Gravidez , Taxa de Gravidez , Adulto Jovem
17.
Conscious Cogn ; 22(3): 816-21, 2013 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-23742871

RESUMO

The resource-based model of self-regulation provides a pessimistic view of self-regulation that people are destined to lose their self-control after having engaged in any act of self-regulation because these acts deplete the limited resource that people need for successful self-regulation. The cognitive control theory, however, offers an alternative explanation and suggests that the depletion effect reflects switch costs between different cognitive control processes recruited to deal with demanding tasks. This account implies that the depletion effect will not occur once people have had the opportunity to adapt to the self-regulatory task initially engaged in. Consistent with this idea, the present study showed that engaging in a demanding task led to performance deficits on a subsequent self-regulatory task (i.e. the depletion effect) only when the initial demanding task was relatively short but not when it was long enough for participants to adapt. Our results were unrelated to self-efficacy, mood, and motivation.


Assuntos
Adaptação Fisiológica/fisiologia , Cognição , Ego , Controles Informais da Sociedade , Adulto , Feminino , Humanos , Masculino , Teoria Psicológica , Desempenho Psicomotor , Autoimagem , Adulto Jovem
18.
Nanotechnology ; 24(13): 135602, 2013 Apr 05.
Artigo em Inglês | MEDLINE | ID: mdl-23478290

RESUMO

We report herein the controllable generation of encodable multi-fluorescence CdTe@carbon nanoparticles (CdTe@C NPs) via the pyrolysis of quantum dot/photonic crystal (QD/PC) guest-host ensembles. The precursors of CdTe/poly(styrene-co-glycidylmethacrylate) (PS-co-PGMA) QD/PC guest-host ensembles were initially formed via the assembly of epoxy groups of PCs and carboxyl groups on the surface of CdTe QDs, followed by a pyrolysis process to generate CdTe@C NPs. The as-prepared CdTe@C NPs not only integrate the optical properties for both the carbon and CdTe QD constituents, but also enable an impressive enhancement of the fluorescence lifetime for CdTe QDs. The multifarious fluorescent spectra coding for CdTe@C NPs was further generated through regulating the embedded sizes or concentrations of CdTe QDs and the excitation wavelength, and their applications in DNA detection and luminescent patterns were achieved.


Assuntos
Compostos de Cádmio/química , Carbono/química , Corantes Fluorescentes/síntese química , Medições Luminescentes/métodos , Nanopartículas/química , Pontos Quânticos , Telúrio/química , Cristalização/métodos , Substâncias Macromoleculares/química , Teste de Materiais , Conformação Molecular , Nanopartículas/ultraestrutura , Tamanho da Partícula , Propriedades de Superfície
19.
Endocrine ; 43(3): 714-23, 2013 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-23008094

RESUMO

The roles of uncoupling protein-2 (UCP2) on the androgen synthesis of granulosa cells derived from patients with polycystic ovary syndrome (PCOS) and normal subjects were explored. Primary human granulosa cells from 18 patients who received in vitro fertilization (IVF) were examined; nine patients had PCOS with hyperandrogenism. Primary cultures were treated with genipin, a proton leak inhibitor, guanosine diphosphate (GDP), an UCP inhibitor, and triiodothyronine (T3), an inducer of UCP gene expression. Mitochondrial membrane potential was determined using the JC-1 assay. T3 induced P450scc and UCP2 expressions and testosterone synthesis in both normal and PCOS granulosa cells. Their expressions in response to T3 treatments were correlated in the PCOS group. Differences in testosterone synthesis were observed between normal and PCOS cells in response to genipin. Increased mitochondrial membrane potential was observed in response to genipin and GDP; while T3 decreased it. Increased ovarian UCP2 expression in response to T3 treatment in PCOS may alter pregnenolone synthesis by influencing P450scc expression, thus altering testosterone production. Further in vivo studies are necessary to fully elucidate the role of UCP2 in the hyperandrogenism commonly observed in PCOS.


Assuntos
Células da Granulosa/metabolismo , Hiperandrogenismo/metabolismo , Canais Iônicos/metabolismo , Proteínas Mitocondriais/metabolismo , Síndrome do Ovário Policístico/metabolismo , Testosterona/biossíntese , Adulto , Aromatase/genética , Aromatase/metabolismo , Células Cultivadas , Feminino , Células da Granulosa/efeitos dos fármacos , Células da Granulosa/patologia , Guanosina Difosfato/farmacologia , Humanos , Hiperandrogenismo/genética , Hiperandrogenismo/patologia , Canais Iônicos/genética , Iridoides/farmacologia , Potencial da Membrana Mitocondrial/efeitos dos fármacos , Proteínas Mitocondriais/genética , Síndrome do Ovário Policístico/genética , Síndrome do Ovário Policístico/patologia , Tri-Iodotironina/farmacologia , Proteína Desacopladora 2
20.
Soc Cogn Affect Neurosci ; 7(2): 222-9, 2012 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-21382966

RESUMO

Our recent work showed that close relationships result in shared cognitive and neural representations of the self and one's mother in collectivistic individuals (Zhu et al., 2007, Neuroimage, 34, 1310-7). However, it remains unknown whether close others, such as mother, father and best friend, are differentially represented in collectivistic brains. Here, using functional magnetic resonance imaging and a trait judgment task, we showed evidence that, while trait judgments of the self and mother generated comparable activity in the medial prefrontal cortex (MPFC) and anterior cingulate (ACC) of Chinese adults, trait judgments of mother induced greater MPFC/ACC activity than trait judgments of father and best friend. Our results suggest that, while neural representations of the self and mother overlapped in the MPFC/ACC, close others such as mother, father and best friend are unequally represented in the MPFC/ACC of collectivistic brains.


Assuntos
Giro do Cíngulo/fisiologia , Julgamento/fisiologia , Mães/psicologia , Córtex Pré-Frontal/fisiologia , Adulto , Encéfalo/fisiologia , Mapeamento Encefálico , Pai/psicologia , Feminino , Amigos/psicologia , Humanos , Processamento de Imagem Assistida por Computador , Imageamento por Ressonância Magnética , Masculino , Autoimagem , Adulto Jovem
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