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1.
Artigo em Inglês | MEDLINE | ID: mdl-33466637

RESUMO

Ciclovía Recreativa is a program in which streets are closed off to automobiles so that people have a safe and inclusive space for recreation and for being physically active. The study aims were: (1) to compare participant's spatial trajectories in four Ciclovía Recreativa programs in Latin America (Bogotá, Mexico City, Santiago de Cali, and Santiago de Chile) according to socioeconomic characteristics and urban segregation of these cities; and (2) to assess the relationship between participants' physical activity (PA) levels and sociodemographic characteristics. We harmonized data of cross-sectional studies including 3282 adults collected between 2015 and 2019. We found the highest mobility for recreation in Bogotá, followed closely by Santiago de Cali. In these two cities, the maximum SES (socioeconomic status) percentile differences between the neighborhood of origin and the neighborhoods visited as part of the Ciclovía use were 33.58 (p-value < 0.001) and 30.38 (p-value < 0.001), respectively, indicating that in these two cities, participants were more likely to visit higher or lower SES neighborhoods than their average SES-of-neighborhood origin. By contrast, participants from Mexico City and Santiago de Chile were more likely to stay in geographic units similar to their average SES-of-origin, having lower overall mobility during leisure time: maximum SES percentile difference 1.55 (p-value < 0.001) and -0.91 (p-value 0.001), respectively. PA levels of participants did not differ by sex or SES. Our results suggest that Ciclovía can be a socially inclusive program in highly unequal and segregated urban environments, which provides a space for PA whilefacilitat physical proximity, exposure to new communities and environments, and interactions between different socioeconomic groups.

2.
Data Brief ; 32: 106287, 2020 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-32923550

RESUMO

This paper presents three data sets about the consequences of COVID-19 pandemic on mental health and subjective wellbeing in Colombia for three population subgroups: adults (+18 years old), college students, and informal workers. The data was gathered using three different online surveys in Colombia, South America. Each online survey had a different collection process. For adults and informal workers, we use a snowballing sampling strategy. For college students, we use social networks and students associations' platforms. In total 2253 individuals participated in the data collection. The surveys aims at informing policymakers and academics about the consequences of COVID-19 in the wellbeing of three population groups. The datasets available in this report includes sociodemographic variables, standardized measures of subjective wellbeing, questions concerning to the pandemic and the quarantine, and emotional closeness with friends and keen. Information of informal workers includes a wide range of information about economic outcomes, like job stability, alternative income, financial inclusion, government welfare, and consumption patterns. This paper presents descriptive and correlation analysis of the variables included in the surveys. The information of this report aims at contributing to a broader discussion, beyond the epidemiological side, of the consequences of the pandemic on the population health. This data in brief is valuable by contributing records from a country in the global South, a region where information for policymaking and academic research is usually scarce. Before the pandemic unfolded, there were reports of high subjective wellbeing in Latin America, by studying subjective wellbeing in the middle of a crisis, is possible to examine how a crisis of this dimension affects the population wellbeing and resilience.

3.
Behav Neurosci ; 134(2): 166-176, 2020 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-31971415

RESUMO

Chronic social stress in early puberty results in enhanced impulsive action-in particular, decreased action inhibition. We address possible effects of early stress on the capacity to wait to respond, the other form of impulsive action. Male golden hamsters were exposed daily to aggressive adults from postnatal Day 28 to Day 42. Later in adulthood, animals were trained in a variable delay to respond task to nose-poke into a lit opening that triggered the delivery of food pellet rewards in response to a house light. During testing, we introduced random and varying delays between the house light presentation and illumination in the openings and examined premature nose-poking responses as an indicator of impulsive action. As delays grew longer, animals performed more premature responses. However, previously stressed animals were 25% less likely to perform such actions by the longest delay. As a control for this experiment, we conducted a separate study in which we introduced varying delays between the nose-poking response in the lit openings and the delivery of the reward. In this case, there were no significant differences between groups in repeated nose-poking after a correct response (repetitive responses). In summary, early stress has differential effects in response to introduction of delays in conditioning procedures: enhanced tolerance to delays between conditioning cues but no effect on responses when rewards are delayed. These studies confirm that early stress impacts the maturation of the neural systems mediating impulsive responses and provide a new perspective on the neuropsychology of waiting. (PsycINFO Database Record (c) 2020 APA, all rights reserved).


Assuntos
Comportamento Impulsivo , Recompensa , Estresse Psicológico/psicologia , Animais , Condicionamento Operante , Feminino , Masculino , Mesocricetus , Tempo de Reação , Maturidade Sexual , Fatores de Tempo
4.
J Community Health ; 45(1): 133-140, 2020 02.
Artigo em Inglês | MEDLINE | ID: mdl-31429007

RESUMO

This study aims to identify factors associated with the probability of trash pickers feeling physically or mentally ill and assesses differences by gender. To achieve these, we estimated multivariate regression models by using data from a census' update of 3109 trash pickers in Cali-Colombia in 2015. Outcomes are defined by two binary variables for whether the trash picker reports 14 or more days during the last month with physical and mental illness. Factors included demographic, family, psychological, socioeconomic and job characteristics. We found gender differences in several risk factors. Also a strong link between physical and mental health was found. Trash picker women are more vulnerable than men, public policy interventions aimed at prevention and treatment of mental health problems will have a positive side effect on their physical and mental health.

5.
Data Brief ; 27: 104639, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31700956

RESUMO

This paper describes a dataset about institutional and interpersonal trust, life satisfaction and health in Cali, one of the major cities in Colombia, South America. Data was collected with the purpose of monitoring trust levels in the population and to serve as baseline information to monitor changes in population trust after the implementation of government interventions aimed at increasing institutional trust. Data was collected in 2017 with subsequent waves in 2018 and 2019, this manuscript presents data collected in 2017, which corresponds to the data analyzed in the paper related to this manuscript. The information was gathered through a population survey to over 1200 adults' city residents, randomly selected in face to face interviews. Data described also reports information on life satisfaction, physical and mental health, and socioeconomic characteristics. This information is useful for policy making purposes insofar as allow the monitoring of outcomes that are relevant for local and national governments that implement programs that affect trust, subjective well-being and health. Taken as a whole, data also allow to build composite indicators for interpersonal and institutional trust and social capital. This research was fully financed by Universidad Icesi through the Observatorio de Políticas Públicas -POLIS- to monitor citizens' perceptions of a different array of government interventions that affect the outcomes in which data was collected. Measures on trust, life satisfaction, and health follow international measurement standards set by the OEDC and Centers for Disease Control and Prevention to allow international comparisons.

6.
SSM Popul Health ; 8: 100423, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31321278

RESUMO

This paper assesses whether two factors of wellbeing, social capital (interpersonal trust and social networks) and subjective well-being are associated with frequent mental distress and if there are any mediating effects by gender in a city of high urban violence. This paper relies on data that comes from a sample of over 1300 people representative by gender, race/ethnicity, and socioeconomic breakdown of the city of Cali in Colombia, which was collected in 2017 through face-to-face surveys. Our study uses logistic regression with fixed-effects at the district level to control for unobserved time-invariant factors. At the individual level, our analyses account for social and demographic context variables. The dependent variable is mental distress, defined as having 14 or more days feeling mentally ill in the previous 30-day period. Independent variables of interest are "interpersonal trust in unknown people" measured in a scale 0-10 and, social networks measured using the number of family members and close friends and subjective well-being through a question about life satisfaction in a scale 0-10. We find risk factors for mental health distress were low trust in unknown people, low life satisfaction, high levels of depression, living in cohabitation, being female, not having children, and living in middle socio-economic status. The odds of feeling mentally ill decreased as trust in unknown people increased by each unit in the trust scale (OR: 0.92). There were gender differences, with women's mental health being less likely to be affected by lack of interpersonal trust (OR: 0.94) than men (OR: 0.76). Our study suggests that actions aimed at fostering interpersonal trust in unknown people could positively affect mental health distress for both males and females. In the context of high urban violence, our study shows that men are more likely to benefit from such actions.

7.
Data Brief ; 24: 103714, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-31049369

RESUMO

This paper presents data about the indebtedness of the poor, in particular, street vendors from Cali, Colombia. In Latin America, as in many other developing regions, the poor have no access to credit from regulated institutions. Bank fees, transaction costs and lack of durable assets to back up indebtedness, exclude the poor form the banking system and their only resort for credit are moneylenders who charge predatory interest rates. In order to assess the economic implications of payday loans, information about indebtedness was collected amongst street vendors in Cali, Colombia. A random sample of 300 street vendors was surveyed at two large street vending sites in the city in 2016. Respondents were inquired about income, expenses, household composition, and access to banking services, credit, and indebtedness. This data in brief presents the value of the gathered information, the general characteristics of this research and the methodology used. Data of this manuscript is associated with the publication Martinez, L., & Rivera-Acevedo, J. D. (2018).

8.
Data Brief ; 23: 103695, 2019 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-30788403

RESUMO

This data article describes two data sets about the socioeconomic conditions of recyclers in Cali, the third largest city in Colombia, South America. Data collected were aimed at understanding the social and economic conditions of this population in order to provide information for crafting policy alternatives for poverty alleviation. Information was collected in two waves in 2013 and in 2015. The first data collection (2013) was focused on a subgroup of recyclers and the second data collection (2015) was a census. In total, more than 3000 direct surveys to recyclers were conducted at individual and family level. In both data collection rounds, information about socioeconomic factors, health, working conditions, access to welfare programs and family composition was gathered. Both data rounds were financed by the local government as an input to design policy interventions to improve the recyclers' quality of life in the city. The data of this manuscript is associated with the publication (Estrada et al., 2017).

9.
Methods Mol Biol ; 1913: 119-131, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30666602

RESUMO

Characteristics of melanoma cells have been deciphered by studies carried out in two dimensional cell cultures growing as adherent monolayers on the bottom of plastic flasks. Melanoma cells can be cultured with a considerable degree of success, and, depending on the further use of the cells obtained in the culture, methodologies have to be adjusted to obtain reliable results. Although there are many melanoma continuous cell lines, in vitro 2D and 3D melanoma primary cell culture may be a more useful model to investigate interactions between cancer cells and immune system, as well as the effect of cytotoxic treatments and personalized medicine in environments more similar to the physiological conditions.Here, we described a protocol which employs many strategies to obtain primary 2D and 3D melanoma cultures as a model to study cell-cell and cell-microenvironment interactions that must be considered to properly design personalized cancer treatments, as well as for testing novel anticancer drugs and drug delivery vehicles.


Assuntos
Antineoplásicos/farmacologia , Ensaios de Seleção de Medicamentos Antitumorais/métodos , Melanoma/patologia , Cultura Primária de Células/métodos , Neoplasias Cutâneas/patologia , Antineoplásicos/uso terapêutico , Biópsia , Comunicação Celular/efeitos dos fármacos , Comunicação Celular/imunologia , Sobrevivência Celular/efeitos dos fármacos , Resistencia a Medicamentos Antineoplásicos/imunologia , Ensaios de Seleção de Medicamentos Antitumorais/instrumentação , Humanos , Melanoma/sangue , Melanoma/tratamento farmacológico , Melanoma/imunologia , Cultura Primária de Células/instrumentação , Neoplasias Cutâneas/sangue , Neoplasias Cutâneas/tratamento farmacológico , Neoplasias Cutâneas/imunologia , Manejo de Espécimes/instrumentação , Manejo de Espécimes/métodos , Esferoides Celulares , Microambiente Tumoral/efeitos dos fármacos , Microambiente Tumoral/imunologia
10.
Sci Rep ; 8(1): 14799, 2018 10 04.
Artigo em Inglês | MEDLINE | ID: mdl-30287878

RESUMO

Freshwater fungi are key decomposers of organic material and play important roles in nutrient cycling, bio-remediation and ecosystem functioning. Although aquatic fungal communities respond to pollution, few studies have quantitatively assessed the effect of freshwater contamination on fungal diversity and composition; and knowledge is scarcer for tropical systems. Here we help fill this knowledge gap by studying a heavily-contaminated South American river spanning a biodiversity hotspot. We collected 30 water samples scattered across a quality gradient over two seasons and analyzed them using Terminal Restriction Fragment Length Polymorphisms (T-RFLP) coupled with 454 Pyrosequencing. Using T-RFLP we identified 451 and 442 Operational Taxonomy Units (OTUs) in the dry and rainy seasons respectively, whereas Pyrosequencing revealed 48,553 OTUs from which 11% were shared between seasons. Although 68% of all identified OTUs and 51% of all identified phyla remained unidentified, dominant fungal phyla included the Ascomycota, Basidiomycota, Chytridiomycota, Glomeromycota, Zygomycota and Neocallimastigomycota, while Calcarisporiella, Didymosphaeria, Mycosphaerella (Ascomycota) and Rhodotorula (Basidiomycota) were the most abundant genera. Fungal diversity was affected by pH and dissolved iron, while community composition was influenced by dissolved oxygen, pH, nitrate, biological oxygen demand, total aluminum, total organic carbon, total iron and seasonality. The presence of potentially pathogenic species was associated with high pH. Furthermore, geographic distance was positively associated with community dissimilarity, suggesting that local conditions allowed divergence among fungal communities. Overall, our findings raise potential concerns for human health and the functioning of tropical river ecosystems and they call for improved water sanitation systems.


Assuntos
Fungos/classificação , Fungos/isolamento & purificação , Micobioma , Rios/microbiologia , Poluentes Químicos da Água/análise , Qualidade da Água , Análise da Demanda Biológica de Oxigênio , Sequenciamento de Nucleotídeos em Larga Escala , Concentração de Íons de Hidrogênio , Polimorfismo de Fragmento de Restrição , Estações do Ano , América do Sul , Clima Tropical
11.
J Urban Health ; 95(3): 391-400, 2018 06.
Artigo em Inglês | MEDLINE | ID: mdl-29204844

RESUMO

Obesity and frequent mental and physical distress are often associated with major health problems. The characteristics of the urban environment, such as homicide rates and public goods provision, play an important role in influencing participation in physical activity and in overall mental health. This study aimed to determine whether there was a relationship between homicide rates and public goods provision on the health outcomes of the citizens of Cali, Colombia, a city known for its high urban violence rate and low municipal investment in public goods. We used a linear probability model to relate homicide rates and public goods provision (lighted parks, effective public space per inhabitant, and bus stations) at the district level to health outcomes (obesity and frequent mental and physical distress). Individual data were obtained from the 2014 CaliBRANDO survey, and urban context characteristics were obtained from official government statistics. After controlling for individual covariates, results showed that homicide rates were a risk factor in all examined outcomes. An increase in 1.0 m2 of public space per inhabitant reduced the probability of an individual being obese or overweight by 0.2% (95% confidence interval (CI) = - 0.004 to - 0.001) and the probability of frequent physical distress by 0.1% (95% CI = - 0.002 to - 0.001). On average, the presence of one additional bus station increased the probability of being obese or overweight by 1.1%, the probability of frequent mental distress by 0.3% (95% CI = 0.001-0.004), and the probability of frequent physical distress by 0.02% (95% CI = 0.000-0.003). Living in districts with adequate public space and lighted parks lowers the probability of being obese and high homicide rates, which are correlated with poor health outcomes in Cali, Colombia. Investments in public goods provision and urban safety to reduce obesity rates may contribute to a better quality of life for the population.


Assuntos
Homicídio/estatística & dados numéricos , Saúde da População/estatística & dados numéricos , População Urbana/estatística & dados numéricos , Violência/estatística & dados numéricos , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Colômbia/epidemiologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Fatores de Risco , Fatores Socioeconômicos , Adulto Jovem
12.
Rev. salud bosque ; 8(2): 9-22, 2018. tab, graf, ilus
Artigo em Espanhol | LILACS, COLNAL | ID: biblio-1103328

RESUMO

Objetivo. El cáncer es un fenómeno complejo, se requiere reconocer las creencias y percepciones de pacientes y familiares o cuidadores, que in-fluyen sobre las formas de pensar, decidir y actuar frente a sí mismos y al entorno. Este trabajo tiene la finalidad de ser insumo para el diseño e implementación de programas para el control del cáncer que permitan fomentar la participación y cumplimiento del tratamiento.Materiales y métodos. Se llevó a cabo un estudio cualitativo en el que participaron pacientes con cáncer y familiares o cuidadores, atendidos en el Centro de Educación del Instituto Nacional de Cancerología. Se con-formaron nueve grupos focales. Los datos se sometieron a un análisis del discurso y se utilizó el Atlas.ti, versión 7.0.Resultados. Participaron 88 personas, 39 pacientes y 49 familiares o cui-dadores, de las cuales, el 71,5 % era del sexo femenino y el 85 % era de estrato socioeconómico bajo. Se identificaron creencias y percepciones en torno a la propensión y la gravedad de la enfermedad, así como los beneficios y las barreras frente a su manejo, además de elementos clave para actuar frente a la enfermedad. Entre estos hallazgos surgen, por un lado, aspectos relacionados con la percepción de factores de riesgo y la concepción inicial del cáncer como sinónimo de muerte, y, por otro, se evidencia la existencia de distintos tipos de barreras para la obtención de un diagnóstico temprano.Conclusión. Los programas de prevención y detección temprana del cán-cer deben incluir en sus estrategias las creencias y percepciones de los individuos frente al cáncer, mejorando las estrategias de información, educación y comunicación dirigidas a la comunidad, a fin de que sean reconocidas y legitimadas para lograr mejores resultados en salud pública.


Objective: Cancer is a complex phenomenon in which beliefs and perceptions of patients and carers are key in understanding ways of thinking and acting. This study aims at providing a star-ting point for further devising and implementing programs gea-red towards increasing patient participation and compliance to cancer-related treatments.Tools and methods: A qualitative study was conducted with the participation of cancer patients and carers seeking care at the education center of a Colombian institution providing health care to cancer patients (Instituto Nacional de Cancerología). Nine focus groups were carried out; Atlas Ti version 7.0 was used for data analysis. Further analysis was implemented with the use of discourse analysisResults: This study was carried out with 88 participants; 39 pa-tients and 49 carers. 71.5% of the sample accounted for women. Sociodemographic data indicated that 85% of the participants of this study were classified as having low or medium income. Throughout the present study, beliefs and perceptions about cancer-related susceptibility, benefits and perceived barriers we-re identified. The findings of this study highlight risk factor per-ceptions and various barriers related to early diagnosis access. Conclusion: Cancer ­ related prevention and early detection programs ought to include beliefs and perceptions within their scope, when devising information, education and communica-tion strategies targeting communities, thus allowing for better outcomes in public health.


Objetivo: O câncer é um fenômeno complexo que requer con-hecimento das crenças e percepções dos próprios pacientes e seus parentes cuidadores, para entender melhor suas formas de pensar, decidir e atuar. Este artigo busca se tornar um insumo na criação e implementação de programas para o controle de câncer que facilitem a participação e aderência ao tratamento. Materiais e métodos: Estudo qualitativo com participação de pacientes com câncer e seus parentes cuidadores do Centro de Educação do Instituto Nacional de Cancerología. Foram reali-zados 9 grupos focais, sua análise foi feita com Atlas Ti versão 7.0 e a análise de dados foi feito com análise de discurso.Resultados: Participaram 88 pessoas, 39 pacientes e 49 paren-tes cuidadores, dentre eles 71,5% mulheres e 85% de baixa renda. Foram identificadas crenças e percepções em torno da susceptibilidade e gravidade da doença, mesmo como proble-mas no tratamento e diagnóstico e outros elementos chave para agir perante a doença. Conclusão: Os programas de prevenção e detecção precoce do câncer devem incluir estratégias que aprofundem as crenças e percepções dos sujeitos perante o câncer, para melhorar as es-tratégias de informação, educação e comunicação e conseguir maior legitimidade do tratamento e melhora nos impactos da saúde pública.


Assuntos
Humanos , Masculino , Feminino , Detecção Precoce de Câncer , Neoplasias , Características Culturais , Cultura
13.
Data Brief ; 14: 132-137, 2017 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-28795089

RESUMO

This data brief describes data collected in Cali, Colombia about the economic dynamic and socioeconomic conditions of street vendors in the city. The study was conducted between 2014 and 2016 in two populated sites in terms of formal and informal commerce in the city. We present the methodology followed in the study, location of street vending sites and type of data collected to approximate to the economic dimension of street vending. Data collected contains information about sociodemographic characteristics, life satisfaction, business operation and characteristics, income and expenses, official license for operation. This information is linked to the publication (Martinez et al., 2017) [1].

14.
Data Brief ; 13: 600-604, 2017 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-28725662

RESUMO

This paper describes one large multi-annual research project-CaliBRANDO-about subjective wellbeing in a developing country. CaliBRANDO is a life satisfaction measurement system implemented in Cali, the third largest city in Colombia, South America. Data have been collected annually since 2014 and aim at collecting comprehensive temporal information about individual-level subjective wellbeing and its relationship with government performance. CaliBRANDO is the only study in Colombia that measures subjective wellbeing in a large city in this way. This paper presents the methodology followed in the study and discusses the relevance of the data collected.

15.
Behav Neurosci ; 131(3): 249-261, 2017 06.
Artigo em Inglês | MEDLINE | ID: mdl-28471223

RESUMO

In hamsters, individuals attacked by adults during puberty become aggressive adults. Perhaps, enhanced aggression observed as repeated attacks toward opponents is associated with a lack of impulse control. We examined impulsive action in male golden hamsters exposed daily to aggressive adults from postnatal Day 28 to 42. These animals were trained in conditioning chambers and tested during adulthood in a go-no-go task addressing action inhibition. Overall, previously stressed hamsters were less likely to inhibit a conditioned lever pressing response during no-go trials. Because this effect could be the result of an extinction impairment, additional animals were tested to evaluate their response to omission of reward associated with conditioned lever pressing. In this experiment, all animals were equally capable of inhibiting their conditioned response. The capacity to inhibit a conditioned response was further addressed by testing responses to a 60-s reward delay after lever pressing. In this case, previously stressed animals were faster to inhibit lever pressing and stopped showing a preference for the proximity of the lever. These studies show selective condition-dependent effects on lever pressing activity and support the possibility that stress in early puberty enhances impulsive action in adulthood. These experiments may be relevant to the study of mental disorders associated with early trauma in humans. (PsycINFO Database Record


Assuntos
Condicionamento Operante/fisiologia , Comportamento Impulsivo/fisiologia , Inibição Psicológica , Desempenho Psicomotor/fisiologia , Estresse Psicológico/fisiopatologia , Fatores Etários , Animais , Animais Recém-Nascidos , Comportamento de Escolha/fisiologia , Modelos Animais de Doenças , Extinção Psicológica , Privação de Alimentos , Mesocricetus , Tempo de Reação/fisiologia , Recompensa
16.
Arthritis Care Res (Hoboken) ; 69(6): 857-866, 2017 06.
Artigo em Inglês | MEDLINE | ID: mdl-27428176

RESUMO

OBJECTIVE: B cell-depletion therapy based on rituximab is a therapeutic option for refractory disease in patients with systemic lupus erythematosus (SLE). The aim of this observational study was to document long-term effects on B cell function by following serum immunoglobulin levels in patients with SLE treated with rituximab in routine clinical practice. METHODS: We included 57 consecutive patients with SLE treated with rituximab and concomitant/sequential immunosuppressants and measured serum total IgG, IgM, and IgA and IgG anti-dsDNA antibodies, over a median of 48 months most recent followup. Flow cytometry was used prospectively to assess B cell phenotypes in 17 of 57 patients. RESULTS: Twelve patients (21%) had persistent IgM hypogammaglobulinemia (<0.4 gm/liter), and 4 of 57 (5%) had low IgG (<7 gm/liter) at the most recent followup (range 12-144 months). This was not associated with serious adverse events or high anti-double-stranded DNA (anti-dsDNA) antibodies (>1,000 IU/ml; normal <50 IU/ml). Factors predictive of low serum IgM included baseline serum IgM ≤0.8 gm/liter (receiver operator curve analysis) and subsequent therapy with mycophenolate mofetil (MMF; odds ratio 6.8, compared with other immunosuppressants). In patients maintaining normal IgM levels (9 of 17), the frequency of circulating IgD+CD27+ B cells was significantly higher (P = 0.05). At 12 months after rituximab, 7 of 30 SLE patients with baseline anti-dsDNA ≤1,000 IU/ml had lost seropositivity. CONCLUSION: Lower baseline serum IgM levels and sequential therapy with MMF were predictive of IgM hypogammaglobulinemia after rituximab in SLE, but this was not associated with higher levels of anti-dsDNA antibodies or an increased risk of infections. This provides useful directions for clinicians regarding rituximab and sequential immunosuppressive treatment for patients with SLE.


Assuntos
Antirreumáticos/uso terapêutico , Imunoglobulina M/sangue , Lúpus Eritematoso Sistêmico/sangue , Lúpus Eritematoso Sistêmico/tratamento farmacológico , Rituximab/uso terapêutico , Adolescente , Adulto , Idoso , Biomarcadores/sangue , Estudos Transversais , Feminino , Seguimentos , Humanos , Lúpus Eritematoso Sistêmico/diagnóstico , Masculino , Pessoa de Meia-Idade , Rituximab/farmacologia , Fatores de Tempo , Resultado do Tratamento , Adulto Jovem
17.
Acta neurol. colomb ; 32(1): 2-8, ene.-mar. 2016. ilus, tab
Artigo em Espanhol | LILACS-Express | LILACS | ID: lil-779502

RESUMO

Introducción: el estado epiléptico (EE) es una emergencia neurológica con alta morbi-mortalidad asociada, el tratamiento se debe fundamentar en las guías internacionales. Objetivo: describir la frecuencia de uso de los anticonvulsivantes empleados en el manejo del EE en dos hospitales de cuarto nivel en Colombia. Materiales y métodos: serie de pacientes mayores de 14,5 años, con diagnóstico de EE establecido por el servicio de Neurología, tratados entre agosto de 2013 y julio de 2014. Resultados: se incluyeron 84 casos, con una mediana de edad de 52,5 años rango intercuartílico (RIQ 27-71,5); el 64,3% de los pacientes (n=54) tenían antecedentes de epilepsia. El tipo de estado epiléptico más frecuente fue tónico-clónico en el 57,1% (n=48) y la causa principal epilepsia no controlada en el 53,6% (n=46). Para el manejo de primera línea, la mitad de los pacientes recibieron combinaciones de benzodiazepinas con otro anticonvulsivante, los más usados fueron fenitoina y ácido valproico. Todos los fármacos antiepilépticos de primera línea se administraron por vía endovenosa. En 32 pacientes (38,1%) se requirió el manejo en la unidad de cuidados intensivos. El resultado, muerte de 17 pacientes (20,2%) y secuelas neurológicas sin muerte en 6 pacientes (7,2%). Conclusión: los fármacos antiepilépticos clásicos, entre los que se encuentran la fenitoina y el ácido valproico, continúan siendo la elección en la primera línea para el tratamiento del EE. La combinación de ácido valproico y levetiracetam puede ser efectiva en el EE refractario. Las medidas alternativas durante el tratamiento del EE no fueron observadas.


Introduction: Status Epilepticus (SE) is a neurological emergency associated with high morbidity and mortality; treatment should be based on international guidelines. Objective: To describe the frequency of application of anticonvulsants used for the treatment of SE in hospitals of level 4 in Colombia. Materials and methods: A series of patients over 14.5 years old, with the diagnosis of SE registered by the neurologist, treated between August 2013 and July 2014. Results: A series of 84 cases, with a median patient age of 52,5 years (IQR 27-71,5); 64.3% of patients (n=54) have featured the previous history of epilepsy. The most frequent type of epileptic status was tonic and clonic among 57,1% (n=48), and the main cause has been uncontrolled epilepsy among 53,6% (n=46). The first-line treatment of the patients was combinations of benzodiazepine with other anticonvulsants, among which the most applied were phenytoin and valproic acid. All anticonvulsants were administered intravenously. 32 patients (38,1%) have required management in intensive care unit. The outcomes were death in 17 cases (20,2%) and 6 patients (7,2%) had neurological sequels without death. Conclusion: The classical antiepileptic drugs, among which are phenytoin and valproic acid, remain the election in the first-line treatment of SE. The combination of valproic acid and levetiracetam may be effective in refractory SE. Alternative therapies of SE were not observed in hospitals of the study.

18.
Behav Brain Res ; 291: 60-66, 2015 Sep 15.
Artigo em Inglês | MEDLINE | ID: mdl-25986403

RESUMO

The object recognition task is a procedure based on rodents' natural tendency to explore novel objects which is frequently used for memory testing. However, in some instances novelty preference is replaced by familiarity preference, raising questions regarding the validity of novelty preference as a pure recognition memory index. Acute stress- and corticosterone administration-induced novel object preference disruption has been frequently interpreted as memory impairment; however, it is still not clear whether such effect can be actually attributed to either mnemonic disruption or altered novelty seeking. Seventy-five adult male Wistar rats were trained in an object recognition task and subjected to either acute stress or corticosterone administration to evaluate the effect of stress or corticosterone on an object recognition task. Acute stress was induced by restraining movement for 1 or 4h, ending 30 min before the sample trial. Corticosterone was injected intraperitoneally 10 min before the test trial which was performed either 1 or 24h after the sample trial. Four-hour, but not 1-h, stress induced familiar object preference during the test trial performed 1h after the sample trial; however, acute stress had no effects on the test when performed 24h after sample trial. Systemic administration of corticosterone before the test trial performed either 1 or 24h after the sample trial also resulted in familiar object preference. However, neither acute stress nor corticosterone induced changes in locomotor behaviour. Taken together, such results suggested that acute stress probably does not induce memory retrieval impairment but, instead, induces an emotional arousing state which motivates novelty avoidance.


Assuntos
Corticosterona/metabolismo , Reconhecimento Psicológico/fisiologia , Estresse Psicológico/metabolismo , Doença Aguda , Animais , Corticosterona/administração & dosagem , Modelos Animais de Doenças , Hormônios/administração & dosagem , Hormônios/metabolismo , Masculino , Atividade Motora/efeitos dos fármacos , Atividade Motora/fisiologia , Testes Neuropsicológicos , Distribuição Aleatória , Ratos Wistar , Reconhecimento Psicológico/efeitos dos fármacos , Restrição Física , Fatores de Tempo
19.
J Occup Environ Med ; 57(3): e26-9, 2015 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-25742544

RESUMO

The Occupational Medicine Forum is prepared by the ACOEM Occupational and Environmental Medical Practice Committee and does not necessarily represent an official ACOEM position. The Forum is intended for health professionals and is not intended to provide medical or legal advice, including illness prevention, diagnosis or treatment, or regulatory compliance. Such advice should be obtained directly from a physician and/or attorney.


Assuntos
Promoção da Saúde/organização & administração , Serviços de Saúde do Trabalhador/organização & administração , Saúde do Trabalhador , Humanos , Estados Unidos , Local de Trabalho
20.
Rev Chilena Infectol ; 31(5): 549-54, 2014 Oct.
Artigo em Espanhol | MEDLINE | ID: mdl-25491453

RESUMO

INTRODUCTION: During malaria infection, both parasite and host are under the effects of oxidative stress due to the increased production of reactive oxygen species, which can induce DNA damage by its genotoxic effects. OBJECTIVE: To evaluate genotoxic effects in human lymphocytes in a cohort of patients with malaria from Medellin and Quibdó. METHODS: We performed an observational cross sectional study in 100 individuals with malaria and 100 healthy controls. Patients infected with Plasmodium consulting the Institute Colombiano of Medicina Tropical of Medellin and the Hospital Ismael Roldán Valencia of Quibdó were included. Genotoxic effects (genetic damage) was analysed by electrophoresis using alkaline single cell gel (Commet assay). RESULTS: The average of tail length of malaria samples (26.9±9.8) was significantly higher than of controls (14.8±3.2) (p<0.01). CONCLUSION: In our study population, malaria infection was associated with increased genotoxicity, while other variables such as smoking, antimalarial treatment, and occupation were not.


Assuntos
Dano ao DNA/genética , Linfócitos/parasitologia , Malária Falciparum/genética , Malária Vivax/genética , Estresse Oxidativo/genética , Estudos de Casos e Controles , Colômbia , Estudos Transversais , Feminino , Humanos , Malária Falciparum/tratamento farmacológico , Malária Vivax/tratamento farmacológico , Masculino , Plasmodium falciparum , Plasmodium vivax , Fatores de Risco , Fumar
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