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1.
BMJ ; 368: l6775, 2020 01 31.
Artigo em Inglês | MEDLINE | ID: mdl-32005673

RESUMO

The studyDambha-Miller H, Day AJ, Strelitz J, et al. Behaviour change, weight loss and remission of Type 2 diabetes: a community-based prospective cohort study. Diabet Med 2019. doi:10.1111/dme.14122This project was funded by the NIHR Health Technology Assessment Programme (project number 08/116/300) as well as the Wellcome Trust (grant number: G061895), the Epidemiology Unit programme (MC_UU_12015/4), and the National Health Service R&D support funding.To read the full NIHR Signal, go to: https://discover.dc.nihr.ac.uk/content/signal-000841/weight-loss-after-type-2-diabetes-diagnosis-boosts-chance-of-remission.


Assuntos
Diabetes Mellitus Tipo 2 , Perda de Peso , Peso Corporal , Humanos , Estudos Prospectivos , Medicina Estatal
2.
BMJ ; 367: l4962, 2019 11 04.
Artigo em Inglês | MEDLINE | ID: mdl-31685480

RESUMO

The studyEveritt H, Landau G, Little P. Therapist telephone-delivered CBT and web-based CBT compared with treatment as usual in refractory irritable bowel syndrome: the ACTIB three-arm RCT. Health Technol Assess 2019;23:1-154.This project was funded by the NIHR Health Technology Assessment Programme (project number 11/69/02).To read the full NIHR Signal, go to https://discover.dc.nihr.ac.uk/content/signal-000784/irritable-bowel-syndrome-helped-by-telephone-or-internet-cbt.


Assuntos
Síndrome do Intestino Irritável , Humanos , Internet , Fonoterapia , Avaliação da Tecnologia Biomédica , Telefone
3.
BMJ ; 367: l4993, 2019 11 04.
Artigo em Inglês | MEDLINE | ID: mdl-31685481

RESUMO

The studyGilbert R, Brown M, Rainford N et al. Antimicrobial-impregnated central venous catheters for prevention of neonatal bloodstream infection (PREVAIL): an open-label, parallel-group, pragmatic, randomised controlled trial. Lancet Child Adolesc Health 2019;3:381-90.The study was funded by the NIHR Health Technology Assessment programme (project number 12/167/02).To read the full NIHR Signal, go to https://discover.dc.nihr.ac.uk/content/signal-000782/antimicrobial-central-venous-catheters-for-pre-term-babies-do-not-reduce-infections.


Assuntos
Anti-Infecciosos , Bacteriemia , Cateteres Venosos Centrais , Antibacterianos , Criança , Humanos , Lactente , Recém-Nascido , Avaliação da Tecnologia Biomédica
4.
BMJ ; 367: l5464, 2019 11 11.
Artigo em Inglês | MEDLINE | ID: mdl-31712247

RESUMO

The studyLyttle MD, Rainford NEA, Gamble C, et al. Levetiracetam versus phenytoin for second-line treatment of paediatric convulsive status epilepticus (EcLiPSE): a multicentre, open-label, randomised trial. Lancet 2019;393:2125-34.This trial was funded by the NIHR Health Technology Assessment Programme (project number 12/127/134).To read the full NIHR Signal, go to https://discover.dc.nihr.ac.uk/content/signal-000790/levetiracetam-vs-phenytoin-in-stopping-childrens-prolonged-epileptic-seizures.


Assuntos
Epilepsia , Estado Epiléptico , Criança , Humanos , Levetiracetam , Fenitoína , Convulsões
5.
BMJ ; 367: l5456, 2019 10 01.
Artigo em Inglês | MEDLINE | ID: mdl-31575520

RESUMO

The studyTaylor RS, Walker S, Ciani O, et al. Exercise-based cardiac rehabilitation for chronic heart failure: the EXTRAMATCH II individual participant data meta-analysis. Health Technol Assess 2019;23:1-98.This project was funded by the NIHR Health Technology Assessment Programme (project number 15/80/30).To read the full NIHR Signal, go to https://discover.dc.nihr.ac.uk/content/signal-000803/cardiac-rehabilitation-for-heart-failure-can-improve-quality-of-life-and-fitness.


Assuntos
Reabilitação Cardíaca , Insuficiência Cardíaca , Exercício , Terapia por Exercício , Humanos , Qualidade de Vida
6.
BMJ ; 367: l5462, 2019 10 09.
Artigo em Inglês | MEDLINE | ID: mdl-31597637

RESUMO

The studyPeden CJ, Stephens T, Martin G et al. Effectiveness of a national quality improvement programme to improve survival after emergency abdominal surgery (EPOCH): a stepped-wedge cluster-randomised trial. Lancet 2019;393:2213-21.This project was funded by the NIHR Health Services and Delivery Research Programme (project number 12/5005/10).To read the full NIHR Signal, go to https://discover.dc.nihr.ac.uk/content/signal-000789/national-quality-improvement-programmes-need-time-and-resources-to-have-impact.


Assuntos
Dor Abdominal/cirurgia , Procedimentos Cirúrgicos do Sistema Digestório , Tratamento de Emergência , Melhoria de Qualidade/organização & administração , Doença Aguda , Análise por Conglomerados , Procedimentos Clínicos , Procedimentos Cirúrgicos do Sistema Digestório/normas , Tratamento de Emergência/normas , Humanos , Avaliação de Programas e Projetos de Saúde , Melhoria de Qualidade/normas
7.
BMJ ; 366: l5453, 2019 09 27.
Artigo em Inglês | MEDLINE | ID: mdl-31562125

RESUMO

The studyTaylor S, Mallett S, Beare S et al. Diagnostic accuracy of whole-body MRI versus standard imaging pathways for metastatic disease in newly diagnosed colorectal cancer: the prospective Streamline C trial. Lancet Gastroenterol Hepatol 2019;4:529-37.This project was funded by the NIHR Health Technology Assessment Programme (project number 10/68/01).To read the full NIHR Signal, go to https://discover.dc.nihr.ac.uk/content/signal-000797/identifying-metastatic-disease-in-colorectal-cancer-with-whole-body-mri.


Assuntos
Neoplasias Colorretais , Segunda Neoplasia Primária , Humanos , Imagem por Ressonância Magnética , Estudos Prospectivos , Avaliação da Tecnologia Biomédica
8.
BMJ ; 366: l4915, 2019 08 27.
Artigo em Inglês | MEDLINE | ID: mdl-31455630

RESUMO

The studyA Rodger, V Cambiano, T Bruun, et al. Risk of HIV transmission through condomless sex in serodifferent gay couples with the HIV-positive partner taking suppressive antiretroviral therapy (PARTNER): final results of a multicentre, prospective, observational study. Lancet 2019;393:2428-38.This project was funded by the NIHR Research for Patient Benefit Programme (project number PB-PG-1013-32069).To read the full NIHR Signal, go to https://discover.dc.nihr.ac.uk/content/signal-000785/antiretroviral-treatment-can-reduce-the-risk-of-hiv-transmission-between-male-partners-to-zero.


Assuntos
Infecções por HIV , Minorias Sexuais e de Gênero , HIV , Humanos , Masculino , Estudos Prospectivos , Parceiros Sexuais
9.
BMJ ; 366: l4920, 2019 08 29.
Artigo em Inglês | MEDLINE | ID: mdl-31466942

RESUMO

The studyStory A, Aldridge R, Smith C, et al. Smartphone-enabled video-observed versus directly observed treatment for tuberculosis: a multicentre, analyst-blinded, randomised, controlled superiority trial. Lancet 2019;393:1216-24.The study was funded by the NIHR Programme Grants for Applied Research programme (project number RP-PG-0407-10340).To read the full NIHR Signal, go to https://discover.dc.nihr.ac.uk/content/signal-000777/smartphones-for-tb-treatment-observation.


Assuntos
Smartphone , Tuberculose , Humanos
10.
BMJ ; 366: l4912, 2019 08 23.
Artigo em Inglês | MEDLINE | ID: mdl-31444168

RESUMO

The studyFeatherstone K, Northcott A, Harden J, et al. Refusal and resistance to care by people living with dementia being cared for within acute hospital wards: an ethnographic study. Health Serv Deliv Res 2019;7.This study was funded by the National Institute for Health Research Health Services and Delivery Research Programme (project number 13/10/80).To read the full NIHR Signal, go to https://discover.dc.nihr.ac.uk/content/signal-000779/understanding-dementia-care-in-hospitals.


Assuntos
Demência/enfermagem , Demência/psicologia , Hospitalização , Cooperação do Paciente , Inglaterra , Humanos , Relações Profissional-Paciente , Medicina Estatal/normas , País de Gales
11.
BMJ ; 366: l4235, 2019 07 10.
Artigo em Inglês | MEDLINE | ID: mdl-31292128

RESUMO

The studyGazzard G, Konstantakopoulou G, Garway-Heath E, et al. Selective laser trabeculoplasty versus eye drops for first-line treatment of ocular hypertension and glaucoma (LiGHT): a multicentre randomised controlled trial. Lancet 2019; doi:10.1016/S0140-6736(18)32213-XThis project was funded by the NIHR Health Technology Assessment Programme (project number 09/104/40) and was sponsored by the Moorfields Eye Hospital NHS Foundation Trust.To read the full NIHR Signal, go to https://discover.dc.nihr.ac.uk/content/signal-000774/early-glaucoma-laser-eye-treatment-trabeculoplasty.


Assuntos
Glaucoma de Ângulo Aberto/cirurgia , Terapia a Laser/métodos , Hipertensão Ocular/cirurgia , Glaucoma de Ângulo Aberto/tratamento farmacológico , Humanos , Terapia a Laser/efeitos adversos , Hipertensão Ocular/tratamento farmacológico , Soluções Oftálmicas , Complicações Pós-Operatórias , Prostaglandinas Sintéticas/efeitos adversos , Prostaglandinas Sintéticas/uso terapêutico , Anos de Vida Ajustados por Qualidade de Vida , Resultado do Tratamento
12.
BMJ ; 366: l4230, 2019 07 02.
Artigo em Inglês | MEDLINE | ID: mdl-31266745

RESUMO

The studyFawsitt C, Thom H, Hunt L. Choice of prosthetic implant combinations in total hip replacement: cost-effectiveness analysis using UK and Swedish hip joint registries data. Value Health 2019;22:303-12.This study was funded by the NIHR Research for Patient Benefit Programme (project number PB-PG-0613-31032).To read the full NIHR Signal, go to https://discover.dc.nihr.ac.uk/content/signal-000771/a-traditional-hip-implant-is-as-effective-as-more-expensive-newer-types-for-older-people.


Assuntos
Artroplastia de Quadril , Desenho de Equipamento , Prótese de Quadril , Complicações Pós-Operatórias , Reoperação , Idoso , Artroplastia de Quadril/efeitos adversos , Artroplastia de Quadril/instrumentação , Artroplastia de Quadril/métodos , Cerâmica/uso terapêutico , Análise Custo-Benefício , Desenho de Equipamento/métodos , Desenho de Equipamento/normas , Feminino , Prótese de Quadril/classificação , Prótese de Quadril/normas , Humanos , Masculino , Próteses Articulares Metal-Metal , Osteoartrite do Quadril/cirurgia , Polietileno/uso terapêutico , Complicações Pós-Operatórias/etiologia , Complicações Pós-Operatórias/cirurgia , Falha de Prótese/efeitos adversos , Reoperação/métodos , Reoperação/estatística & dados numéricos , Reino Unido
13.
BMJ ; 365: l4223, 2019 Jun 20.
Artigo em Inglês | MEDLINE | ID: mdl-31221622

RESUMO

The studyClare L, Kudlicka A, Oyebode J R, et al. Goal-oriented cognitive rehabilitation for early-stage Alzheimer's and related dementias: the GREAT RCT. Health Technol Assess 2019;23:1-242.The trial was funded by the NIHR Health Technology Assessment Programme (project number11/15/04).To read the full NIHR Signal, go to: https://discover.dc.nihr.ac.uk/content/signal-000767/goal-setting-in-early-stage-dementia-can-improve-function.


Assuntos
Disfunção Cognitiva/economia , Disfunção Cognitiva/reabilitação , Demência/psicologia , Atividades Cotidianas , Disfunção Cognitiva/psicologia , Análise Custo-Benefício , Demência/economia , Demência/epidemiologia , Demência/reabilitação , Metas , Humanos , Estudos Multicêntricos como Assunto , Ensaios Clínicos Controlados Aleatórios como Assunto , Autoeficácia , Avaliação da Tecnologia Biomédica , Resultado do Tratamento , Reino Unido
14.
BMJ ; 365: l2036, 2019 May 10.
Artigo em Inglês | MEDLINE | ID: mdl-31076461

RESUMO

The studyHajek P, Phillips-Waller A, Przulj D, et al. A randomised trial of e-cigarettes versus nicotine-replacement therapy. N Engl J Med 2019;380:629-37.This trial was funded by the NIHR Health Technology Assessment Programme (12/167/135) and by Cancer Research UK.To read the full NIHR Signal, go to https://discover.dc.nihr.ac.uk/content/signal-000757/e-cigarettes-helped-more-smokers-quit-than-nicotine-replacement-therapy.


Assuntos
Sistemas Eletrônicos de Liberação de Nicotina/estatística & dados numéricos , Nicotina/uso terapêutico , Fumantes/estatística & dados numéricos , Abandono do Hábito de Fumar/métodos , Dispositivos para o Abandono do Uso de Tabaco/estatística & dados numéricos , Análise Custo-Benefício , Humanos , Fumantes/psicologia , Abandono do Hábito de Fumar/psicologia , Resultado do Tratamento
15.
BMJ ; 364: l1029, 2019 Mar 25.
Artigo em Inglês | MEDLINE | ID: mdl-30910804

RESUMO

The studyFOCUS Trial Collaboration. Effects of fluoxetine on functional outcomes after acute stroke (FOCUS): a pragmatic, double-blind, randomised, controlled trial. Lancet 2019;393:256-74.The study was funded by the UK Stroke Association and the NIHR Health Technology Assessment Programme project number 13/04/30.To read the full NIHR Signal, go to: https://discover.dc.nihr.ac.uk/content/signal-000729/a-commonly-used-antidepressant-doesnt-improve-recovery-after-stroke.

16.
BMJ ; 364: l1025, 2019 Mar 18.
Artigo em Inglês | MEDLINE | ID: mdl-30885906

RESUMO

The studyJolliffe D, Greenberg L, Hooper R, Mathyssen C, Rafiq R, de Jongh R, Camargo C, Griffiths C, Janssens W, Martineau A. Vitamin D to prevent exacerbations of COPD: systematic review and meta-analysis of individual participant data from randomised controlled trials. Thorax 2019. doi:10.1136/thoraxjnl-2018-212092This project was funded by the National Institute for Health Research Health Technology Appraisal programme (project number 13/03/25).To read the full NIHR Signal, go to: https://discover.dc.nihr.ac.uk/content/signal-000737/treating-vitamin-d-deficiency-may-reduce-exacerbations-of-copd.

17.
BMJ ; 364: k4259, 2019 Mar 04.
Artigo em Inglês | MEDLINE | ID: mdl-30833377

RESUMO

The studyA randomised trial of epinephrine in out-of-hospital cardiac arrestPerkins GD, Ji C, Deakin CD, Quinn T, Nolan JP, Scomparin C, Regan S, Long J, Slowther A, Pocock H, Black JJM, Moore F, Fothergill RT, Rees N, O'Shea L, Docherty M, Gunson I, Han K, Charlton K, Finn J, Petrou S, Stallard N, Gates S, Lall R for the PARAMEDIC2 CollaboratorsPublished on 18 July 2018 N Engl J Med 2018;379:711-21.This project was funded by the National Institute for Health Research HTA Programme (project number 12/127/126).To read the full NIHR Signal, go to: https://discover.dc.nihr.ac.uk/content/signal-000639/adrenaline-can-restart-the-heart-but-is-no-good-for-the-brain.


Assuntos
Epinefrina/administração & dosagem , Parada Cardíaca/tratamento farmacológico , Doenças do Sistema Nervoso/induzido quimicamente , Reanimação Cardiopulmonar/métodos , Epinefrina/efeitos adversos , Epinefrina/uso terapêutico , Parada Cardíaca/complicações , Humanos , Estudos Observacionais como Assunto , Taxa de Sobrevida , Simpatomiméticos/efeitos adversos , Simpatomiméticos/uso terapêutico , Reino Unido/epidemiologia
18.
BMJ ; 364: k4411, 2019 03 13.
Artigo em Inglês | MEDLINE | ID: mdl-30867157

RESUMO

The studyEffect of negative pressure wound therapy vs standard wound management on 12-month disability among adults with severe open fracture of the lower limb: the WOLLF randomised clinical trial.Costa ML, Achten J, Bruce J, et al; UK WOLLF CollaborationPublished on 9 October 2018 JAMA 2018;319:2280-8.This project was funded by the National Institute for Health Research Health Technology Assessment Programme (project number 10/57/20).To read the full NIHR Signal, go to: https://discover.dc.nihr.ac.uk/content/signal-000655/negative-pressure-dressings-are-no-better-than-standard-dressings-for-open-fractures.


Assuntos
Bandagens/tendências , Fraturas Expostas/terapia , Extremidade Inferior/lesões , Tratamento de Ferimentos com Pressão Negativa/métodos , Bandagens/normas , Avaliação da Deficiência , Pessoas com Deficiência/psicologia , Pessoas com Deficiência/estatística & dados numéricos , Fraturas Expostas/complicações , Fraturas Expostas/microbiologia , Fraturas Expostas/cirurgia , Humanos , Extremidade Inferior/patologia , Tratamento de Ferimentos com Pressão Negativa/instrumentação , Tratamento de Ferimentos com Pressão Negativa/normas , Qualidade de Vida , Avaliação da Tecnologia Biomédica , Ferimentos e Lesões/epidemiologia , Ferimentos e Lesões/patologia , Ferimentos e Lesões/terapia
19.
BMJ ; 364: l571, 2019 Feb 15.
Artigo em Inglês | MEDLINE | ID: mdl-30770340

RESUMO

The studySheppard JP, Stevens S, Stevens R, Martin U, Mant J, Hobbs R, McManus R. Benefits and harms of antihypertensive treatment in low-risk patients with mild hypertension.Published on 1 December 2018 JAMA Intern Med 2018;178:1626-34.This project was funded by a grant from the National Institute for Health Research (NIHR-RP-R2-12-O15) and the Medical Research Council (MRC) Strategic Skills Postdoctoral Fellowship.To read the full NIHR Signal, go to: https://discover.dc.nihr.ac.uk/content/signal-000713/lifestyle-changes-for-mild-hypertension-rather-than-drugs.


Assuntos
Anti-Hipertensivos/uso terapêutico , Hipertensão/prevenção & controle , Comportamento de Redução do Risco , Desprescrições , Gerenciamento Clínico , Seguimentos , Guias como Assunto , Humanos , Educação de Pacientes como Assunto , Estudos Retrospectivos , Resultado do Tratamento
20.
BMJ ; 364: k5339, 2019 02 19.
Artigo em Inglês | MEDLINE | ID: mdl-30782586

RESUMO

The studyHome treatment of COPD exacerbation selected by DECAF score: a non-inferiority, randomised controlled trial and economic evaluationEchevarria C, Gray J, Hartley T, Miller J, Simpson AJ, Gibson GJ, Bourke SCPublished on 24 April 2018 Thorax 2018;73:713-22This project was funded by the National Institute for Health Research-Research for Patient Benefit Programme (project number PB-PG-0213-30105).To read the full NIHR Signal, go to: https://discover.dc.nihr.ac.uk/content/signal-000691/hospital-at-home-treatment-for-copd-flare-ups.


Assuntos
Alta do Paciente , Doença Pulmonar Obstrutiva Crônica , Análise Custo-Benefício , Humanos
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