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Rev Med Suisse ; 17(748): 1453-1456, 2021 Sep 01.
Artigo em Francês | MEDLINE | ID: mdl-34468096


Treatment of hepatitis C has known major progress thanks to direct-acting antivirals resulting in the healing, defined by a viral clearance (sustained virological response [SVR]), in the vast majority of patients. However, there is a residual risk of progressive liver damage in a minority of patients, potentially leading to complications such as liver decompensation, hepatocellular carcinoma and/or death. This article discusses the current knowledge of residual liver disease after treatment, the impact of comorbidities and the factors potentially predicting patients at risk of complications and warranting surveillance.

Carcinoma Hepatocelular , Hepatite C Crônica , Hepatite C , Neoplasias Hepáticas , Antivirais/uso terapêutico , Carcinoma Hepatocelular/epidemiologia , Carcinoma Hepatocelular/etiologia , Hepacivirus , Hepatite C/complicações , Hepatite C/tratamento farmacológico , Hepatite C/epidemiologia , Hepatite C Crônica/complicações , Hepatite C Crônica/tratamento farmacológico , Hepatite C Crônica/epidemiologia , Humanos , Cirrose Hepática/tratamento farmacológico , Neoplasias Hepáticas/epidemiologia , Neoplasias Hepáticas/etiologia
Rev Med Suisse ; 16(704): 1560-1563, 2020 Sep 02.
Artigo em Francês | MEDLINE | ID: mdl-32880112


Foreign bodies ingestion is a common event, with a potential morbidity and mortality. In the majority of cases, the foreign bodies pass through the digestive tract without any complication. An endoscopy for removal of the foreign body is necessary in 10 to 20 % of cases and a surgical intervention is required in < 1 % of cases. In this article, we describe the clinical presentation, the potential complications, as well as the timing and endoscopic technics of foreign bodies retrieval, essentially based on the European Society of Gastrointestinal Endoscopy recommendations.

Endoscopia Gastrointestinal/métodos , Endoscopia Gastrointestinal/normas , Corpos Estranhos/cirurgia , Trato Gastrointestinal/cirurgia , Humanos , Guias de Prática Clínica como Assunto
Rev Med Suisse ; 15(660): 1478-1482, 2019 Aug 28.
Artigo em Francês | MEDLINE | ID: mdl-31496170


Digestive endoscopy has met an enormous progress over the last decade, both in terms of diagnosis and treatment of gastro-intestinal diseases. This review article presents the role of confocal endomicroscopy in the management of pancreatic cysts. Moreover, it resumes the most important novel therapeutic endoscopic techniques, some already available in expert centers such as G-POEM or biliary drainage by Axios stent system and spiral enteroscopy, as well as techniques undergoing validation such as the radiofrequency ablation of pancreatic tumors and the bariatric and metabolic endoscopy techniques.

Endoscopia Gastrointestinal/tendências , Gastroenteropatias , Drenagem , Gastroenteropatias/diagnóstico , Humanos , Laparoscopia , Neoplasias Pancreáticas/cirurgia , Stents
Cell Rep ; 19(3): 451-460, 2017 04 18.
Artigo em Inglês | MEDLINE | ID: mdl-28423309


Flavivirus infections by Zika and dengue virus impose a significant global healthcare threat with no US Food and Drug Administration (FDA)-approved vaccination or specific antiviral treatment available. Here, we present the discovery of an anti-flaviviral natural product named cavinafungin. Cavinafungin is a potent and selectively active compound against Zika and all four dengue virus serotypes. Unbiased, genome-wide genomic profiling in human cells using a novel CRISPR/Cas9 protocol identified the endoplasmic-reticulum-localized signal peptidase as the efficacy target of cavinafungin. Orthogonal profiling in S. cerevisiae followed by the selection of resistant mutants pinpointed the catalytic subunit of the signal peptidase SEC11 as the evolutionary conserved target. Biochemical analysis confirmed a rapid block of signal sequence cleavage of both host and viral proteins by cavinafungin. This study provides an effective compound against the eukaryotic signal peptidase and independent confirmation of the recently identified critical role of the signal peptidase in the replicative cycle of flaviviruses.

Produtos Biológicos/farmacologia , Vírus da Dengue/fisiologia , Lipopeptídeos/farmacologia , Replicação Viral/efeitos dos fármacos , Zika virus/fisiologia , Produtos Biológicos/química , Sistemas CRISPR-Cas/genética , Vírus da Dengue/efeitos dos fármacos , Técnicas de Silenciamento de Genes , Genoma Humano , Genômica , Células HCT116 , Humanos , Lipopeptídeos/química , Proteínas de Membrana , Subunidades Proteicas/metabolismo , Saccharomyces cerevisiae/efeitos dos fármacos , Saccharomyces cerevisiae/genética , Serina Endopeptidases , Proteínas Virais/metabolismo , Zika virus/efeitos dos fármacos