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1.
Assessment ; : 1073191120918010, 2020 May 21.
Artigo em Inglês | MEDLINE | ID: mdl-32436398

RESUMO

Objective: The Psychology Experiment Building Language (PEBL) Test Battery is a recent computerized software for the assessment of cognitive functioning in clinical and healthy populations. However, its applicability for the assessment of old adults and the role of level of familiarity with technology on performance have not been tested. Method: To verify if PEBL Test Battery is sensitive to aging cognitive decline, we assessed young and older adults' performance on the neuropsychological tests relative to the following domains: verbal and visuospatial short-term memory, selective attention, inhibition to interference, planning and problem-solving, set-shifting, and cognitive flexibility. The difference between the two groups was studied taking into account the self-reported level of familiarity with technology, measured through the Attitudes Toward Computers Questionnaire. Results: Old participants showed a lower level of cognitive performance compared with the younger group, in line with the traditional literature about cognitive function decline in aging. However, this difference was not related to the level of familiarity with technology. Conclusion: Our descriptive study seemed to support the applicability of PEBL Test Battery for testing old adults' cognitive functioning. However, some criticisms and future improvements about this computerized battery were discussed for its applicability in clinical, rehabilitative and research contexts.

2.
Neuropsychology ; 34(4): 479-492, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-32134282

RESUMO

OBJECTIVE: It was suggested that the bimanual coupling effect might be linked to motor intentionality and planning, which are the top-down components of motor execution. However, previous results in pathological and healthy individuals have also underlined the pivotal role of bottom-up sensorimotor information. METHOD: In this single-case study, the Circles-Lines Coupling Task was administered to a left-parietal-brain-damaged individual. The cerebral lesion caused a central proprioceptive loss, relative to the impaired right hand, when out of the visual control. For the 1st time in literature, we sought to investigate whether the movement of the unaffected hand induced an efficient coupling effect on the movement of the affected one. The bimanual task was performed in the presence and absence of visual input. The patient's performance was compared with that of healthy controls. RESULTS: We observed the traditional bimanual coupling effect in healthy controls. Moreover, we also replicated the effect when they performed the task blindfolded. In the case of the patient, both hands showed the typical ovalization of the line trajectory when the task was performed in visual modality. It is interesting that when the patient performed the task blindfolded, the trajectories of the impaired right hand seemed to be not influenced by the concomitant circular movement of the spared left hand. CONCLUSIONS: The movement of the unaffected hand induced a bimanual coupling effect on the movement of the affected one only when the visual input was available. In absence of a visual feedback, the aberrant proprioceptive information might preclude the emerging of bimanual coupling, even in the case of a preserved motor intentionality and planning. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

3.
Multisens Res ; : 1-15, 2020 Jan 23.
Artigo em Inglês | MEDLINE | ID: mdl-31978872

RESUMO

Preliminary evidence showed a reduced temporal sensitivity (i.e., larger temporal binding window) to audiovisual asynchrony in obesity. Our aim was to extend this investigation to visuotactile stimuli, comparing individuals of healthy weight and with obesity in a simultaneity judgment task. We verified that individuals with obesity had a larger temporal binding window than healthy-weight individuals, meaning that they tend to integrate visuotactile stimuli over an extended range of stimulus onset asynchronies. We point out that our finding gives evidence in support of a more pervasive impairment of the temporal discrimination of co-occurrent stimuli, which might affect multisensory integration in obesity. We discuss our results referring to the possible role of atypical oscillatory neural activity and structural anomalies in affecting the perception of simultaneity between multisensory stimuli in obesity. Finally, we highlight the urgency of a deeper understanding of multisensory integration in obesity at least for two reasons. First, multisensory bodily illusions might be used to manipulate body dissatisfaction in obesity. Second, multisensory integration anomalies in obesity might lead to a dissimilar perception of food, encouraging overeating behaviours.

4.
Neurol Sci ; 2019 Dec 05.
Artigo em Inglês | MEDLINE | ID: mdl-31807997

RESUMO

Clock drawing test (CDT) is a screening tool used in neuropsychological assessment for evaluating comprehensively multiple cognitive functions. Aberrant performance at CDT was observed in Parkinson's disease, due to impaired executive functioning as well as visuospatial difficulties. However, previous studies suffered from different limitations, such as reduced sample size as well as no comparison with healthy individuals. This retrospective study aimed to verify CDT accuracy in discriminating between 240 patients with idiopathic Parkinson's disease and 205 healthy subjects. We verified CDT accuracy in discriminating patients when classified according to their global cognitive functioning measured through the Mini-Mental State Examination and the Frontal Assessment Battery. Our results showed that affected individuals reported a worse performance in CDT than healthy controls. Instead, no difference was found between patients when categorized according to their performance at the Mini-Mental State Examination or Frontal Assessment Battery. We confirmed that patients with Parkinson's disease reported low performance at the CDT. We encouraged the use of CDT for early detection of possible cognitive difficulties in Parkinson's disease for clinical and research purposes.

5.
Multisens Res ; : 1-25, 2019 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-31722290

RESUMO

The Rubber Hand Illusion (RHI) is used widely to investigate the multisensory integration mechanisms that support bodily self-consciousness and, more specifically, body ownership and self-location. It has been reported that individuals affected by obesity show anomalous multisensory integration processes. We propose that these obesity-induced changes could lead to an unusual susceptibility to the RHI and anomalous bodily self-experience. To test this hypothesis, we administered a modified version of the RHI (using a picture of the participant's hand) to individuals affected by obesity and participants with a healthy weight. During synchronous and asynchronous stimulation, we compared the subjective experience of the illusion (using a questionnaire) and the effect of the illusion on self-location (i.e., proprioceptive drift). In accordance with the illusion phenomenology, both groups had a comparable subjective illusory experience after the synchronous stimulation. Nevertheless, individuals affected by obesity showed less recalibration of self-location than healthy weight participants. In light of a recent interpretation of the multisensory integration mechanisms that underpin the RHI, our findings suggest that in obesity visuo-tactile integration supporting the subjective experience of the illusion is preserved, whereas visuo-proprioceptive integration for self-location is reduced.

6.
Sensors (Basel) ; 19(21)2019 Nov 02.
Artigo em Inglês | MEDLINE | ID: mdl-31684020

RESUMO

The increment of the prevalence of neurological diseases due to the trend in population aging demands for new strategies in disease management. In Parkinson's disease (PD), these strategies should aim at improving diagnosis accuracy and frequency of the clinical follow-up by means of decentralized cost-effective solutions. In this context, a system suitable for the remote monitoring of PD subjects is presented. It consists of the integration of two approaches investigated in our previous works, each one appropriate for the movement analysis of specific parts of the body: low-cost optical devices for the upper limbs and wearable sensors for the lower ones. The system performs the automated assessments of six motor tasks of the unified Parkinson's disease rating scale, and it is equipped with a gesture-based human machine interface designed to facilitate the user interaction and the system management. The usability of the system has been evaluated by means of standard questionnaires, and the accuracy of the automated assessment has been verified experimentally. The results demonstrate that the proposed solution represents a substantial improvement in PD assessment respect to the former two approaches treated separately, and a new example of an accurate, feasible and cost-effective mean for the decentralized management of PD.

7.
Front Neurol ; 10: 998, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31620071

RESUMO

Objective: The object of the study was to evaluate the efficacy of Proprioceptive Focal Stimulation on Gait in middle-advanced Parkinson (PD) patients by a crossover, randomized, double Blind double dummy study using Equistasi®, a nano-technological device of the dimension of a plaster which generates High Frequency Vibration (FV). Background: The efficacy of Gait Analysis (GA) on evaluating gait modification on Parkinson's disease (PD) Patients is already well-known. Therefore, GA was recorded in a group of PD patients using Equistasi® device and its placebo. Methods: Forty PD patients on optimal therapy were enrolled in the study. Patients were randomly assigned to receive active or sham stimulation for 8 weeks and, following a wash-out period, switched to an additional 8-week period with the reverse intervention. GA was performed at baseline and at the end of both 8-weeks treatment periods Clinical state was monitored by MDUPDRS part III. Results: Active stimulation induced a significant improvement in Mean Velocity (Velocity), Stride Length (SL), Stance (STA), and Double Support (DST) percentage, both in left and right stride. The ANOVA analysis using H&Y stage as a factor, showed that DST and MDUPDRS III scores improved significantly more in the more severely affected subjects. Conclusions: The findings obtained in this randomized controlled study show the efficacy of mechanical focal vibration, as stimulation of the proprioceptive system, in PD and encourage further investigation. The effect of the device on more severe patients may open a new possibility to identify the most appropriate candidate for the management of gait disturbances and postural instability with FV delivered with Equistasi®.

8.
Sci Rep ; 9(1): 15508, 2019 Oct 29.
Artigo em Inglês | MEDLINE | ID: mdl-31664059

RESUMO

Temporal sensitivity to multisensory stimuli has been shown to be reduced in obesity. We sought to investigate the possible role of the pro-inflammatory state on such alteration, considering the effect of the expression of markers, such as leptin and IL6, which are notably high in obesity. The performance of 15 male individuals affected by obesity and 15 normal-weight males was compared using two audiovisual temporal tasks, namely simultaneity judgment and temporal order judgment. Analyses of serum levels of inflammatory markers of leptin and IL6, and of neurotrophic factors of BDNF and S100SB were quantified. At the behavioral level we confirmed previous evidence showing poorer temporal sensitivity in obesity compared to normal-weight participants. Furthermore, leptin, that is a cytokine overexpressed in obesity, represented the best predictor of behavioral differences between groups in both tasks. The hypothesis we put forward is that the immune system, rather than overall cerebral dysfunction, might contribute to explain the altered temporal sensitivity in obesity. The present finding is discussed within the context of the role of cytokines on the brain mechanisms supporting temporal sensitivity.

9.
NeuroRehabilitation ; 45(2): 247-254, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31498137

RESUMO

BACKGROUND: There are few evidences on safety of Constraint-Induced Movement Therapy (CIMT), as well as its effects in neurological conditions, including multiple sclerosis (MS). OBJECTIVE: To evaluate safety and effectiveness of a 2-week CIMT protocol on upper limb activity of progressive MS patients through a three-dimensional (3D) kinematic analysis. METHODS: In this randomized single-blind pilot study, we randomly allocated patients affected by progressive MS reporting a reduced use of one upper limb into two different groups: CIMT group (less affected limb blocked by a splint) and control group (undergoing bi-manual treatment). Primary outcome was CIMT safety. Furthermore, we assessed CIMT effects through clinical outcomes (hand grip strength, HGS, and 9 Hole Peg Test, 9HPT) and 3D kinematic analysis (normalized jerk, number of movement units, going phase duration, mean velocity, endpoint error). All evaluations were performed at baseline (T0) and after 2 weeks of treatment (T1) for both arms in both groups. RESULTS: Ten MS patients, mean aged 51.0±7.7 years, were randomly allocated in the 2 groups. After treatment, no differences were found in the blocked arm. Furthermore, CIMT group showed significant improvements in clinical and kinematic parameters. CONCLUSIONS: CIMT might be considered a safe and effective technique in MS patients.


Assuntos
Técnicas de Exercício e de Movimento/métodos , Terapia por Exercício/métodos , Esclerose Múltipla/reabilitação , Reabilitação Neurológica/métodos , Extremidade Superior/fisiopatologia , Adulto , Fenômenos Biomecânicos , Técnicas de Exercício e de Movimento/efeitos adversos , Terapia por Exercício/efeitos adversos , Feminino , Força da Mão , Humanos , Masculino , Pessoa de Meia-Idade , Movimento , Projetos Piloto , Método Simples-Cego
10.
J Clin Med ; 8(9)2019 Aug 28.
Artigo em Inglês | MEDLINE | ID: mdl-31466376

RESUMO

Background. The effective illusory ownership over an artificial body in modulating body representations in healthy and eating disorders population has been repeatedly reported in recent literature. In this study, we extended this research in the field of obesity: specifically, we investigated whether ownership over a virtual body with a skinny abdomen might be successfully experienced by participants affected by obesity. Methods. Fifteen participants with obesity and fifteen healthy-weight participants took part at this study in which the VR-Full-Body Illusion was adopted. The strength of illusion was investigated through the traditional Embodiment Questionnaire, while changes in bodily experience were measured through a body size estimation task. Results. Participants with obesity as well as healthy-weight participants reported to experience the illusion. About the body size estimation task, both groups reported changes only in the estimation of the abdomen's circumference after the experimental condition, in absence of any another difference. Discussion. Participants with obesity reported to experience the illusion over a skinny avatar, but the modulation of the bodily experience seems controversial. Future lines of research exploiting this technique for modulating body representations in obesity, specifically in terms of potential therapeutic use, were discussed.

11.
Exp Brain Res ; 237(10): 2505-2521, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31327026

RESUMO

Mixed findings characterize studies in Parkinson's disease (PD): some studies indicate a relationship between physical impairments and the ability to mentally represent the body, while others suggest spared abilities for this cognitive function. To clarify the matter, in the present study we explored the mental representations of the body in action in the same PD patients, taking also into account lateralization of symptoms and visual imagery skills. 10 PD patients with left- (lPD), 10 with right (rPD) lateralized symptoms (lPD), and 20 matched healthy controls have been recruited for the study. All patients were screened for neuropsychological impairments. To explore a more implicit component we used the hand laterality task (HLT), while the mental motor chronometry (MMC) was used to explore a more explicit one. Two control tasks, with objects instead of body parts, were administered to control for visual imagery skills. In the HLT, we detected the effects of biomechanical constraints effects in both controls and PD patients. In the latter group, importantly, this was true independently from lateralization of symptoms. In the MMC, we found the expected positive correlation between executed and imagined movements for both hands in controls only, while all PD patients, again independently form lateralization, only showed this effect for the left hand. In terms of visual imagery, only rPD patients differed from controls when asked to implicitly rotate letters, and in terms of accuracy only. However, this difference is explained by executive functions measured through the neuropsychological assessment rather than by a "pure" visual imagery impairment. In summary, our findings suggest that two different aspects of the mental representations of the body in action, one more implicit and the other more explicit, can be differently affected by PD. These impairments are unlikely explained by a basic visual imagery deficit. When present, impairments concern a higher dimension, related to motor functions and awareness, and not driven by sensory impairments, as shown by the independence of effects from physical laterality of symptoms.


Assuntos
Corpo Humano , Movimento/fisiologia , Doença de Parkinson/fisiopatologia , Doença de Parkinson/psicologia , Cognição/fisiologia , Feminino , Lateralidade Funcional/fisiologia , Mãos/fisiopatologia , Humanos , Imaginação/fisiologia , Masculino , Pessoa de Meia-Idade , Testes Neuropsicológicos
12.
Sleep Med ; 61: 57-62, 2019 09.
Artigo em Inglês | MEDLINE | ID: mdl-31307885

RESUMO

BACKGROUND: Sleep disorders are frequent in Parkinson's disease (PD). Apart from the occurrence of REM behavior disorders, in the early phase of the disease standard sleep macrostructure evaluation was inconclusive. OBJECTIVE: We analyzed non-rapid eye movement (NREM) sleep microstructure (CAP) in a group of PD patients to provide an objective measure of sleep disruption. METHODS: We recruited 31 PD patients [mean age 59.5 ± 12.4 years; mean Hoehn-Yahr (H-Y) stage: 3.4 ± 1.8] and 34 age-matched non-parkinsonian subjects (mean age 61.5 ± 15.2 years) as a control group. All patients underwent full-night laboratory polysomnography (PSG). Conventional sleep macro/microstructure analysis was performed. Patients were then divided into two groups: group 1 (H-Y stage ≤ 2) and group 2 (H-Y stage ≥ 3). RESULTS: In group 2 PD patients compared to controls, alterations of both sleep macrostructure and microstructure were found. The PD subgroup with milder disease (group 1) presented sleep macrostructure, movements and respiratory parameters not significantly different from controls, although their CAP rate was significantly higher and the proportion of the A1 phase of CAP was reduced (p = 0.03). Multivariate logistic regression showed that disease duration, disease severity, and arousal index emerged as independent predictive factors for CAP rate ≥55% and the A1 phase of CAP ≤40% (p < 0.05). CONCLUSION: The main result of our study consists in the disclosure of altered NREM sleep microstructure in PD even at an early stage of the disease, suggesting an early alteration of the central pathways involved in the NREM sleep building-up and stability.

13.
Biomech Model Mechanobiol ; 18(5): 1429-1442, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31079255

RESUMO

Objective of the work is to investigate stress and deformation that conrneal tissue and donor graft undergo during endothelial keratoplasty. In order to attach the donor graft to the cornea, different air bubble pressure profiles acting on the graft are considered. This study is carried out by employing a three-dimensional nonlinear finite element methodology, combined with a contact algorithm. The ocular tissues are treated as isotropic, hyper-elastic and nearly-incompressible materials. The contact algorithm, based on the penalty-based node-to-surface approach, is used to model the donor graft-corneal interface region. First, the proposed computational methodology is tested against benchmark data for bending of the plates over a cylinder. Then, the influence of geometrical and material parameters of the graft on the corneal contact-structural response is investigated. The results are presented in terms of Von Mises stress intensity, displacement and mean contact force. Results clearly indicate that the air bubble pressure plays a key role in the corneal stress and strain, as well as graft stiffness and thickness.


Assuntos
Transplante de Córnea , Modelos Biológicos , Análise Numérica Assistida por Computador , Algoritmos , Fenômenos Biomecânicos , Córnea/cirurgia , Humanos , Pressão , Estresse Mecânico
14.
Sensors (Basel) ; 19(5)2019 Mar 05.
Artigo em Inglês | MEDLINE | ID: mdl-30841656

RESUMO

A self-managed, home-based system for the automated assessment of a selected set of Parkinson's disease motor symptoms is presented. The system makes use of an optical RGB-Depth device both to implement its gesture-based human computer interface and for the characterization and the evaluation of posture and motor tasks, which are specified according to the Unified Parkinson's Disease Rating Scale (UPDRS). Posture, lower limb movements and postural instability are characterized by kinematic parameters of the patient movement. During an experimental campaign, the performances of patients affected by Parkinson's disease were simultaneously scored by neurologists and analyzed by the system. The sets of parameters which best correlated with the UPDRS scores of subjects' performances were then used to train supervised classifiers for the automated assessment of new instances of the tasks. Results on the system usability and the assessment accuracy, as compared to clinical evaluations, indicate that the system is feasible for an objective and automated assessment of Parkinson's disease at home, and it could be the basis for the development of neuromonitoring and neurorehabilitation applications in a telemedicine framework.


Assuntos
Extremidade Inferior/fisiopatologia , Doença de Parkinson/fisiopatologia , Idoso , Fenômenos Biomecânicos , Feminino , Humanos , Aprendizado de Máquina , Masculino , Pessoa de Meia-Idade , Equilíbrio Postural/fisiologia , Interface Usuário-Computador
15.
Sci Rep ; 9(1): 974, 2019 Jan 30.
Artigo em Inglês | MEDLINE | ID: mdl-30700766

RESUMO

Two-dimensional (2D) nanomaterials have received much attention in recent years, because of their unusual properties associated with their ultra-thin thickness and 2D morphology. Besides graphene, a new 2D material, molybdenum disulfide (MoS2), has attracted immense interest in various applications. On the other hand, ball-milling process provides an original strategy to modify materials at the nanometer scale. This methodology represents a smart solution for the fabrication of MoS2 nanopowders extremely-efficient in adsorbing water contaminants in aqueous solution. This work reports a comprehensive morphological, structural, and physicochemical investigation of MoS2 nanopowders treated with dry ball-milling. The adsorption performances of the produced nanopowders were tested using methylene blue (MB) dye and phenol in aqueous solution. The adsorption capacity as a function of ball-milling time was deeply studied and explained. Importantly, the ball-milled MoS2 nanopowders can be easily and efficiently regenerated without compromising their adsorption capacity, so to be reusable for dye adsorption. The eventual toxic effects of the prepared materials on microcrustacean Artemia salina were also studied. The present results demonstrate that ball-milling of MoS2 offers a valid method for large-scale production of extremely efficient adsorbent for the decontamination of wastewaters from several pollutants.

16.
Complement Ther Med ; 42: 233-239, 2019 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-30670247

RESUMO

BACKGROUND: A style of dance called tango translates clinical practice into a new philosophy and rehabilitative approach for individuals with Parkinson's disease (PD). The style of dance mixes music, self-generated and external cued strategies and social and emotional recovery. In recent years, there has been an increase in the number of studies reporting health benefits for people diagnosed with PD who dance tango. However, there are some organisational limitations to people participating in dance classes, including having trained Tango teachers, an appropriate space for dancing, and schedule that allows for participants with motor inabilities. METHODS: This pilot study involved the observation of PD patients who completed four days of home exercise plus a tango dance lesson each week for five weeks. RESULTS: Ten PD patients improved their quality of life, their motor score on the Unified Parkinson's Disease Rating Scale and their kinematic performances. CONCLUSIONS: We propose a protocol of exercises that has been derived from the tango dance and that can be performed in a patient's home.


Assuntos
Exercício Físico/fisiologia , Doença de Parkinson/fisiopatologia , Doença de Parkinson/terapia , Terapia através da Dança/métodos , Terapia por Exercício/métodos , Feminino , Marcha/fisiologia , Humanos , Masculino , Pessoa de Meia-Idade , Música , Projetos Piloto , Qualidade de Vida
17.
J Colloid Interface Sci ; 533: 369-374, 2019 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-30172147

RESUMO

HYPOTHESIS: If nanocrystals of such semiconductor as SnO2 and TiO2, which are not known as powerful adsorbents, have their surface modified by layer of V2O5, how will the adsorption properties be affected? Answering this question would provide a new set of surface properties to be designed by surface engineering of oxide nanocrystals. EXPERIMENTS: SnO2 and TiO2 colloidal nanocrystals were prepared by coupling sol-gel and solvothermal synthesis. By co-processing with V chloroalkoxide and subsequent heat-treatment at 400-500 °C, surface deposition of V2O5 layers was obtained. The methylene blue adsorption onto the prepared materials was tested and compared with the pure oxide supports. Cycling of the materials and analysis of the adsorption process was also investigated. FINDINGS: The V-modified nanocrystals extracted ∼80% methylene blue from 1.5 × 10-5 M aqueous solution after 15 min only, contrarily to pure materials, which took up only 30% of the dye even after 120 min. Comparison with pure commercial V2O5 showed that the peculiar adsorption properties were imparted by the surface deposition of the V2O5-like layers. This report demonstrates that new classes of adsorbing materials can be conceived by suitably coupling different metal oxides.

18.
Funct Neurol ; 34(3): 151-157, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-32453996

RESUMO

Multiple sclerosis (MS) is a chronic disease of the central nervous system, characterized by demyelinization and axonal loss resulting, in 66% of cases, in upper limb motor impairment. The effects of constraint-induced movement therapy (CIMT) have recently been investigated in MS patients. The aim of this randomized single-blind pilot study was to assess the effects of CIMT on upper limb activity, specifically smoothness of movement, in patients affected by progressive MS. Patients affected by MS, and reporting reduced use primarily of one upper limb, were enrolled and randomly allocated to two different groups: a CIMT group, where treatment was performed with the less affected limb immobilized by a splint, and a control group, submitted to intensive bi-manual treatment. All evaluations were performed at baseline (T0) and after two weeks of treatment (T1) by an operator unaware of the patients' allocation. The primary outcome was the difference in movement smoothness, measured by means of a bidimensional kinematic evaluation. Secondary outcomes were: endpoint error and arm trajectory mean speed. Furthermore, patients performed the Hand Grip Strength Test (HGS) and 9-Hole Peg Test (9HPT), for both arms, at both time points. Ten patients with MS (4 males, 6 females; mean age 51.0±7.7 years) were randomly allocated to the CIMT group (n=5) and control group (n=5). There were no significant differences between groups in any of the data assessed at baseline. In the CIMT group subjects, the treatment effect, in terms of movement smoothness, was significant at the more affected limb (p=0.0376). The CIMT group displayed statistically significant improvements, versus the baseline values, in muscle strength (HGS:22.4±8.3 vs 26.0±6.0; p<0.05) and dexterity (9HPT: 31.8±6.1 vs 27.4±4.9; p<0.05) of the more affected limb. A positive, although not significant, trend in terms of muscle strength and upper limb dexterity was observed, for both limbs, in the control group after the two-week treatment. Bi-dimensional kinematic evaluation demonstrated that the CIMT group showed a significant reduction of endpoint error and higher mean speed for the more affected arm; these data are in line with the significant improvements recorded on the HGS and 9HPT. Moreover, in the CIMT group, a non-significant worsening of muscle strength was recorded for the less affected upper limb.

19.
ACS Appl Mater Interfaces ; 10(46): 40100-40110, 2018 Nov 21.
Artigo em Inglês | MEDLINE | ID: mdl-30358979

RESUMO

The design of new hybrid nanocomposites based on poly(2-hydroxyethylmethacrylate) (pHEMA) graphene oxide (GO) cryosponges, wherein ZnO nanolayers have been deposited to induce photocatalytic properties, is reported here. Atomic layer deposition at low temperature is specifically selected as the deposition technique to stably anchor ZnO molecules to the pendant polymer OH groups. Furthermore, to boost the pHEMA cryogel adsorption capability versus organic dyes, GO is added during the synthetic procedure. The morphology, the crystallinity, and the chemical composition of the samples are deeply investigated by scanning electron microscopy, transmission electron microscopy, X-ray diffraction analyses, Fourier transform infrared spectroscopy, and thermogravimetric analysis. Swelling properties, mechanical performance, and adsorption kinetics models of the hybrid materials are also evaluated. Finally, the adsorption and photocatalytic performance are tested and compared for all of the samples using methylene blue as a dye. Particularly, the adsorption efficiency of ZnO/pHEMA and ZnO/pHEMA-GO nanocomposites, as well as their in situ regeneration via photocatalysis, renders such devices very appealing for advanced wastewater treatment technology.

20.
Sensors (Basel) ; 18(10)2018 Oct 18.
Artigo em Inglês | MEDLINE | ID: mdl-30340420

RESUMO

A home-based, reliable, objective and automated assessment of motor performance of patients affected by Parkinson's Disease (PD) is important in disease management, both to monitor therapy efficacy and to reduce costs and discomforts. In this context, we have developed a self-managed system for the automated assessment of the PD upper limb motor tasks as specified by the Unified Parkinson's Disease Rating Scale (UPDRS). The system is built around a Human Computer Interface (HCI) based on an optical RGB-Depth device and a replicable software. The HCI accuracy and reliability of the hand tracking compares favorably against consumer hand tracking devices as verified by an optoelectronic system as reference. The interface allows gestural interactions with visual feedback, providing a system management suitable for motor impaired users. The system software characterizes hand movements by kinematic parameters of their trajectories. The correlation between selected parameters and clinical UPDRS scores of patient performance is used to assess new task instances by a machine learning approach based on supervised classifiers. The classifiers have been trained by an experimental campaign on cohorts of PD patients. Experimental results show that automated assessments of the system replicate clinical ones, demonstrating its effectiveness in home monitoring of PD.


Assuntos
Autoavaliação Diagnóstica , Monitorização Fisiológica/instrumentação , Monitorização Fisiológica/métodos , Doença de Parkinson/fisiopatologia , Idoso , Idoso de 80 Anos ou mais , Automação , Fenômenos Biomecânicos/fisiologia , Calibragem , Vestuário , Estudos de Coortes , Desenho de Equipamento , Feminino , Dedos/fisiologia , Mãos/fisiologia , Humanos , Masculino , Pessoa de Meia-Idade , Índice de Gravidade de Doença , Software , Interface Usuário-Computador
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