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Sci Rep ; 8(1): 13526, 2018 09 10.
Artigo em Inglês | MEDLINE | ID: mdl-30201978


Wheat is an important staple that acts as a primary source of dietary energy, protein, and essential micronutrients such as iron (Fe) and zinc (Zn) for the world's population. Approximately two billion people suffer from micronutrient deficiency, thus breeders have crossed high Zn progenitors such as synthetic hexaploid wheat, T. dicoccum, T. spelta, and landraces to generate wheat varieties with competitive yield and enhanced grain Zn that are being adopted by farmers in South Asia. Here we report a genome-wide association study (GWAS) using the wheat Illumina iSelect 90 K Infinitum SNP array to characterize grain Zn concentrations in 330 bread wheat lines. Grain Zn phenotype of this HarvestPlus Association Mapping (HPAM) panel was evaluated across a range of environments in India and Mexico. GWAS analysis revealed 39 marker-trait associations for grain Zn. Two larger effect QTL regions were found on chromosomes 2 and 7. Candidate genes (among them zinc finger motif of transcription-factors and metal-ion binding genes) were associated with the QTL. The linked markers and associated candidate genes identified in this study are being validated in new biparental mapping populations for marker-assisted breeding.

Biofortificação , Grão Comestível/genética , Locos de Características Quantitativas , Triticum/genética , Zinco/análise , Mapeamento Cromossômico , Cromossomos de Plantas/genética , Grão Comestível/química , Genoma de Planta/genética , Estudo de Associação Genômica Ampla , Índia , México , Melhoramento Vegetal/métodos , Proteínas de Plantas/genética , Plantas Geneticamente Modificadas/química , Plantas Geneticamente Modificadas/genética , Polimorfismo de Nucleotídeo Único , Sementes/química , Sementes/genética , Triticum/química , Dedos de Zinco/genética
Theor Appl Genet ; 129(8): 1595-605, 2016 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-27170319


KEY MESSAGE: Predictability estimated through cross-validation approach showed moderate to high level; hence, genomic selection approach holds great potential for biofortification breeding to enhance grain zinc and iron concentrations in wheat. Wheat (Triticum aestivum L.) is a major staple crop, providing 20 % of dietary energy and protein consumption worldwide. It is an important source of mineral micronutrients such as zinc (Zn) and iron (Fe) for resource poor consumers. Genomic selection (GS) approaches have great potential to accelerate development of Fe- and Zn-enriched wheat. Here, we present the results of large-scale genomic and phenotypic data from the HarvestPlus Association Mapping (HPAM) panel consisting of 330 diverse wheat lines to perform genomic predictions for grain Zn (GZnC) and Fe (GFeC) concentrations, thousand-kernel weight (TKW) and days to maturity (DTM) in wheat. The HPAM lines were phenotyped in three different locations in India and Mexico in two successive crop seasons (2011-12 and 2012-13) for GZnC, GFeC, TKW and DTM. The genomic prediction models revealed that the estimated prediction abilities ranged from 0.331 to 0.694 for Zn and from 0.324 to 0.734 for Fe according to different environments, whereas prediction abilities for TKW and DTM were as high as 0.76 and 0.64, respectively, suggesting that GS holds great potential in biofortification breeding to enhance grain Zn and Fe concentrations in bread wheat germplasm.

Ferro/análise , Sementes/anatomia & histologia , Triticum/genética , Zinco/análise , DNA de Plantas/genética , Meio Ambiente , Genoma de Planta , Genótipo , Índia , México , Modelos Genéticos , Modelos Estatísticos , Fenótipo , Polimorfismo de Nucleotídeo Único , Triticum/química