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1.
BMC Gastroenterol ; 21(1): 490, 2021 Dec 20.
Artigo em Inglês | MEDLINE | ID: mdl-34930143

RESUMO

BACKGROUND: To assess the association of HSD17B13 rs72613567:TA allelic variant with liver disease, we performed the current review and meta-analysis. METHODS: Seven studies were identified by a search of CNKI,CBM,MEDLINE, PubMed, EMBASE, and CENTRAL databases from inception to November 2021. Odds ratios (ORs) with 95% confidence interval (CI) were calculated using random effects model or fixed effects model based on the between-study heterogeneity. The Stata 14.0 software was employed for data analysis. RESULTS: Statistical analysis showed that the HSD17B13 rs72613567:TA allelic variant can decrease the risk of hepatocellular carcinoma(HCC) in nonalcoholic fatty liver disease (NAFLD) patients, alcoholic fatty liver disease (ALD) patients and viral hepatitis patients (TA vs T OR = 0.766, 95% CI = 0.682-0.860, P = 0.000; TATA + TAT vs TT OR = 0.755, 95% CI = 0.645-0.885, P = 0.001) or healthy controls(TA vs T OR = 0.649, 95% CI = 0.431-0.977, P = 0.038). Besides, the HSD17B13 rs72613567:TA allelic variant can also provide protection from nonalcoholic fatty liver disease (NAFLD) not only in entire population (TA vs T OR = 0.669, 95% CI = 0.524-0.856, P = 0.001) but also in healthy people (TA vs T OR = 0.600, 95% CI = 0.464-0.777, P = 0.000). No significant publication bias found in this airticle. CONCLUSION: The present findings suggest HSD17B13 rs72613567:TA allelic variant can reduce the risk of HCC and NAFLD in the entire population studied.


Assuntos
17-Hidroxiesteroide Desidrogenases/genética , Carcinoma Hepatocelular , Neoplasias Hepáticas , Hepatopatia Gordurosa não Alcoólica , Alelos , Carcinoma Hepatocelular/genética , Humanos , Neoplasias Hepáticas/genética , Hepatopatia Gordurosa não Alcoólica/genética , Razão de Chances
2.
Front Plant Sci ; 12: 649204, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34093612

RESUMO

Mixed-stand plantations are not always as beneficial for timber production and carbon sequestration as monoculture plantations. Systematic analyses of mixed-stand forests as potential ideal plantations must consider the physiological-ecological performance of these plantations. This study aimed to determine whether mixed moso bamboo (Phyllostachys pubescens (Pradelle) Mazel ex J. Houz.) and Chinese fir (Cunninghamia lanceolata (Lamb.) Hook.) stands exhibited better physiological-ecological performance than monoculture plantations of these species. We analyzed leaf photosynthesis, chlorophyll fluorescence, antioxidant enzyme activities, chlorophyll content and leaf chemistry in a moso bamboo stand, a Chinese fir stand and a mixed stand with both species. The results showed that both species in the mixed stand exhibited significantly higher leaf net photosynthesis rate (Amax), instantaneous carboxylation efficiency (CUE), chlorophyll content, maximum quantum yield of photosynthesis (Fv/Fm), photochemical quenching coefficient (qP), PSII quantum yield [Y(II)], leaf nitrogen content, and antioxidant enzyme activities than those in the monoculture plantations. However, the non-photochemical quenching (NPQ) in Chinese fir and 2-year-old moso bamboo was significantly lower in the mixed stand than in the monocultures. In addition, the water use efficiency (WUE) of Chinese fir was significantly higher in the mixed stand. The results suggest that the increase in leaf net photosynthetic capacity and the improved growth in the mixed stand could be attributed primarily to the (i) more competitive strategies for soil water use, (ii) stronger antioxidant systems, and (iii) higher leaf total nitrogen and chlorophyll contents in the plants. These findings suggest that mixed growth has beneficial effects on the leaf photosynthesis capacity and physiological resistance of moso bamboo and Chinese fir.

3.
Neural Plast ; 2020: 8853720, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33204250

RESUMO

Background. Clinically, electroacupuncture (EA) is the most common therapy for aging-related cognitive impairment (CI). However, the underlying pathomechanism remains unidentified. The aims of this study were to observe the effect of EA on cognitive function and explore the potential mechanism by which EA acts on the NLRP3/caspase-1 signaling pathway. Main Methods. Thirty male SAMP8 mice were randomly divided into the model, the 2 Hz EA and 10 Hz EA groups. Ten male SAMR1 mice were assigned to the control group. Cognitive function was assessed through the Morris water maze test. Hippocampal morphology and cell death were observed by HE and TUNEL staining, respectively. The serum IL-1ß, IL-6, IL-18, and TNF-α levels were measured by ELISA. Hippocampal NLRP3, ASC, caspase-1, GSDM-D, IL-1ß, IL-18, Aß, and tau proteins were detected by Western blotting. Key Findings. Cognitive function, hippocampal morphology, and TUNEL-positive cell counts were improved by both EA frequencies. The serum IL-1ß, IL-6, IL-18, and TNF-α levels were decreased by EA treatment. However, 10 Hz EA reduced the number of TUNEL-positive cells in the CA1 region and serum IL-1ß and IL-6 levels more effectively than 2 Hz EA. NLRP3/caspase-1 pathway-related proteins were significantly downregulated by EA, but 2 Hz EA did not effectively reduce ASC protein expression. Interestingly, both EA frequencies failed to reduce the expression of Aß and tau proteins. Significance. The effects of 10 Hz EA at the GV20 and ST36 acupoints on the NLRP3/caspase-1 signaling pathway may be a mechanism by which this treatment relieves aging-related CI in mice.


Assuntos
Envelhecimento/fisiologia , Cognição/fisiologia , Eletroacupuntura , Hipocampo/fisiologia , Transdução de Sinais , Animais , Caspase 1/fisiologia , Masculino , Camundongos , Proteína 3 que Contém Domínio de Pirina da Família NLR/fisiologia
4.
Talanta ; 219: 121173, 2020 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-32887095

RESUMO

Sensitive and specific detection of microRNAs (miRNAs) is of great significance for early cancer diagnosis. Here we report a simple and sensitive fluorescence signal amplification strategy that based on DSN/TdT recycling digestion for miRNA detection. DSN initiates DNA digestion on 3'-phosphate-primer/miRNA heteroduplex which causes miRNA recycle. The digested DNA strands with 3'-OH ends enable TdT to synthesize a polydeoxyguanylic tails on the 3'-end. The DNAs with polydeoxyguanylic tails are converted to double-stranded-DNA prior to initiation of DSN/TdT recycling digestion. With the cooperation of TdT and DSN, a new round of digestion and extension is triggered, leading to massive fluorophores separating and signal amplification. The amplification strategy produces large amounts of 3'-OH probes that can be used directly for dsDNA enrichment and DSN digestion. Moreover, both DSN digestion and TdT extension are sequence-independent reaction without the need of complex sequences design. In addition, this strategy is utilized to analyze miRNA samples from MCF-7 cell lysates and Cu (II) ion samples, indicating its potential application in actual sample analysis. The method shows a promising analytical platform for DNA nicking-related studies and tumor biomarkers measuring in clinical diagnostics.


Assuntos
Técnicas Biossensoriais , MicroRNAs , Sondas de DNA/genética , Digestão , Humanos , MicroRNAs/genética , Técnicas de Amplificação de Ácido Nucleico
5.
Front Plant Sci ; 11: 550, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32457783

RESUMO

As the most widely distributed giant running bamboo species in China, Moso bamboo (Phyllostachys edulis) can accomplish both development of newly sprouted culms and leaf renewal of odd-year-old culms within a few months in spring. The two phenological events in spring may together change water distribution among culms in different age categories within a stand, which may differ from our conventional understanding of the negative age effect on bamboo water use. Therefore, to explore the effect of spring shooting and leaf phenology on age-specific water use of Moso bamboo and potential water redistribution, we monitored water use of four culm age categories (newly sprouted, 1-, 2-, and 3-year-old; namely A0, A1, A2, A3) in spring from March to June 2018. For newly sprouting culms, the spring phenological period was classified into five stages (incubation, culm-elongation, branch-development, leafing, established). Over these phenological stages, age-specific accumulated sap flux density showed different patterns. The oldest culms, A3, were not influenced by leaf renewal and kept nearly constant and less water use than the other aged culms. However, A2, which did not renew their leaves, had the most water use at the two initial stages (incubation, culm-elongation) but consumed less water than A0 and A1 after the fourth stage (leafing). At the end of June, water use of the four age categories sorted in order of A0 > A1 > A2 > A3, which confirms the conventional thought and observations, i.e., a negative age effect. The results indicate that new leaf flushing may benefit younger culms (A1 and A0) more than older culms (A2 and A3), i.e., increasing their transpiration response to radiation and share of the stand transpiration. With the underground connected rhizome system, the bamboo stand as an integration seems to balance its water use among culms of different ages to support the water use of freshly sprouted culms during their developing period.

6.
Front Pharmacol ; 11: 601977, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33408631

RESUMO

Background: To evaluate the efficacy, safeness and cost of ultrasound-guided local lauromacrogol injection (USG-LLI) combined with curettage and hysteroscopy for cesarean scar pregnancy (CSP). Methods: This was a retrospective study included 151 CSP patients diagnosed with CSP from June 2017 to December 2019, and treated by USG-LLI (n = 86) or uterine artery embolization (UAE) (n = 65) combined with curettage and hysteroscopy. Clinical data and outcome were analyzed. Results: There were no significant differences in basic clinical characteristics in the two groups. Two groups showed the similar success rates. USG-LLI group, compared with UAE group had significantly lower complication rates (9.30 vs. 44.62%), lower total costs (both medical and non-medication cost) (p < 0.05). Conclusions: USG-LLI combined with curettage and hysteroscopy is a feasible method to treat CSP with minimal invasion and high efficacy. Moreover, compared with curettage after UAE, USG-LLI exhibited lower complication rate and required fewer expenses.

7.
Artigo em Inglês | MEDLINE | ID: mdl-31781266

RESUMO

Sagacious Confucius' Pillow Elixir (SCPE) is a traditional Chinese medicine that is mainly used for cognitive impairment in aging; however, the underlying mechanisms remain unclear. Aging is one of the most important pathogenic factors leading to inflammation and pyroptosis in the hippocampus, which may be a potential mechanism in elderly patients with cognitive impairment. Here, we examined whether SCPE could improve cognitive impairment in SAMP8 mice by reducing hippocampal inflammation and pyroptosis. Seven-month-old senescence-accelerated P8 mice (SAMP8) received SCPE (2.3 g/kg/day; 4.6 g/kg/day; 9.2 g/kg/day) for 28 days. Cognitive function and morphometric examinations were performed followed by water maze testing, hematoxylin-eosin staining, Congo red staining, toluidine blue staining, and TUNEL analysis of hippocampal CA1 and CA3 regions. Escape latency increased and times across platforms decreased in SAMP8 mice; however, both of them were normalized by SCPE after 28 days. Aging caused significant pyroptosis in hippocampal CA1 and CA3 regions, as evidenced by neuronal degeneration and necrosis, amyloid deposition, and decreased Nissl body amounts after cognitive impairment, which were greatly improved by SCPE. SCPE reduced serum IL-1ß, IL-6, IL-18, and TNF-α levels and reduced hippocampal NLRP3, ASC, caspase-1, GSDM-D, IL-1ß, IL-6, IL-18, and Aß expression. Thus, SCPE exerts an antipyroptotic effect in aging, mainly by suppressing the NLRP3/caspase-1 signaling pathway.

8.
BMC Cancer ; 19(1): 1128, 2019 Nov 21.
Artigo em Inglês | MEDLINE | ID: mdl-31752753

RESUMO

BACKGROUND: Hepatocellular carcinoma (HCC) is the sixth-most common malignancy worldwide. Multiple previous studies have assessed the relationship between TM6SF2 gene polymorphism and the risk of developing HCC, with discrepant conclusions reached. To assess the association of TM6SF2 rs58542926 T/C gene polymorphism with liver cancer, we performed the current meta-analysis. METHODS: This study queried the MEDLINE, PubMed, EMBASE, and CENTRAL databases from inception to April 2019. Case-control studies assessing the relationship between TM6SF2 rs5854292 locus polymorphism and liver cancer were selected according to inclusion and exclusion criteria. The Stata 12.0 software was employed for data analysis. RESULTS: A total of 5 articles, encompassing 6873 patients, met inclusion criteria and were included in the meta-analysis. Statistical analysis showed that the TM6SF2 gene polymorphism was significantly associated with liver cancer in the allele contrast, dominant, recessive and over dominant models (T vs C, OR = 1.621, 95%CI 1.379-1.905; CT + TT vs CC. OR = 1.541, 95%CI 1.351-1.758; TT vs CT + CC, OR = 2.897, 95%CI 1.690-4.966; CC + TT vs TC, OR = 0.693, 95%CI 0.576-0.834). The Egger's test revealed no significant publication bias. CONCLUSION: The present findings suggest a significant association of TM6SF2 gene polymorphism with HCC risk in the entire population studied.


Assuntos
Carcinoma Hepatocelular/genética , Neoplasias Hepáticas/genética , Proteínas de Membrana/genética , Polimorfismo de Nucleotídeo Único , Estudos de Associação Genética , Predisposição Genética para Doença , Humanos
9.
Biosens Bioelectron ; 144: 111692, 2019 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-31522099

RESUMO

A highly flexible electrochemical assay based on target-triggered DNAzyme spiders was proposed for the detection of telomerase. The DNAzyme-telomerase substrate primers (D-TSP) containing Cu2+-dependent DNAzymes serve as recognition elements, and primers of telomerase. Telomerase extracted from Hela cells recognize the D-TSP and elongated with DNA sequence repeats. A synthetic telomerase product hybridized with scaffold sequences of two DNAzyme-tethered probes on the basis of the mechanism of the proximity-ligation assay. The three-leg DNAzyme spiders has been assembled and initiated the autonomous hybridization/nicking/displacement cycles on substrate modified surface. The cleaved ferrocene-labeled fragements are adsorbed on gold surface leading to an increase in the electrochemical signal. As a result, the one input target, telomerase, release large amount of ferrocene-labeled DNA strands, achieving an exponential signal amplification and an excellent improvement in sensitivity over single molecule or two-component 'sandwich' binding complexes. Our proposed biosensor showed a nonlinear dependence with Hela cell numbers, ranging from 25 to 2000 with a detection limit of 10 cells. Telomerase activities from different cell lines were also successfully evaluated. Our electrochemical strategy based on target-triggered DNAzyme spiders was enzyme-free, PCR-free, simple in operation which indicated that it expected to expand the scope of DNA nanotechnology in the areas of clinical diagnosis.


Assuntos
Técnicas Biossensoriais , DNA Catalítico/química , Hibridização de Ácido Nucleico , Telomerase/isolamento & purificação , DNA/química , DNA/genética , Ouro/química , Células HeLa , Humanos , Telomerase/química
10.
BMC Gastroenterol ; 19(1): 81, 2019 May 30.
Artigo em Inglês | MEDLINE | ID: mdl-31146697

RESUMO

BACKGROUND: Ambulatory surgery maintains the advantages of a more rapid return to work and overall reduced hospital costs. The specific impact of ambulatory surgery for anal fistula using the LIFT procedure (ligation of the intersphincteric fistula tract) is presented. METHODS: A total of 218 consecutive patients with anal fistula who underwent ambulatory LIFT surgery were retrospectively compared with 386 cases managed as in-patients. Patient demographics, comorbidities, postoperative morbidity and pain as well as readmission rates within 30 days and satisfaction ratings were compared between the two groups. RESULTS: When compared with patients undergoing in-patient surgery, those in the ambulatory group were younger with a better level of education (P < 0.05). Ambulatory cases returned to work after shorter postoperative periods (P < 0.01) but experienced more frequent postoperative external hemorrhoidal thrombosis and more reported postoperative pain (P < 0.05). There were no differences in the overall rate of complications or readmissions between the two groups. Ambulatory patients reported higher satisfaction ratings than in-patients (P < 0.05). CONCLUSIONS: The LIFT procedure for anal fistula can be safely performed in the ambulatory setting resulting in an acceptable level of satisfaction and a more rapid return to work when compared with in-patient fistula management.


Assuntos
Procedimentos Cirúrgicos Ambulatórios , Hemorragia Pós-Operatória/etiologia , Fístula Retal/cirurgia , Adolescente , Adulto , Procedimentos Cirúrgicos Ambulatórios/efeitos adversos , Estudos de Viabilidade , Feminino , Humanos , Infecções/etiologia , Ligadura , Masculino , Pessoa de Meia-Idade , Dor Pós-Operatória/etiologia , Satisfação do Paciente , Estudos Retrospectivos , Retorno ao Trabalho , Cicatrização , Adulto Jovem
11.
Front Plant Sci ; 10: 786, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31249586

RESUMO

Bamboo culms are connected to neighboring culms via rhizomes, which enable resource exchange between culms. We assessed water transfer between established and neighboring, freshly sprouted culms by thermal dissipation probes (TDP) inserted into culms and the connecting rhizome. During the early phase of sprouting, highest sap flux densities in freshly sprouted culms were observed at night, whereas neighboring established culms had high sap flux densities during daytime. After leaf flushing on freshly sprouted culms, the nighttime peaks disappeared and culms switched to the diurnal sap flux patterns with daytime maxima as observed in established culms. TDP in rhizomes indicated water flowing from the established to the freshly sprouted culms. When the established culms of a clump were cut, freshly sprouted culms without leaves reduced sap flux densities rates by 79%. Our findings thus suggest that bamboos exchange water via rhizomes and that nighttime fluxes are highly important for the support of freshly sprouted culms. The (water) resource support may facilitate the very fast growth of the bamboo shoots, and enable the colonizing of new places.

12.
Sci Rep ; 7(1): 14001, 2017 10 25.
Artigo em Inglês | MEDLINE | ID: mdl-29070868

RESUMO

We propose a scheme for nonreciprocal light propagation in two coupled cavities system, in which a two-level quantum emitter is coupled to one of the optical microcavities. For the case of parity-time ([Formula: see text]) symmetric system (i.e., coupled active-passive cavities system), the cavity gain can significantly enhance the optical nonlinearity induced by the interaction between a quantum emitter and cavity field beyond weak-excitation approximation. The increased optical nonlinearity results in the non-lossy nonreciprocal light propagation with high isolation ratio in proper parameters range. In addition, our calculations show that nonreciprocal light propagation will not be affected by the unstable output field intensity caused by optical bistability, and we can even switch directions of nonreciprocal light propagation by appropriately adjusting the system parameters.

13.
J Phys Chem A ; 121(34): 6510-6516, 2017 Aug 31.
Artigo em Inglês | MEDLINE | ID: mdl-28787163

RESUMO

The geometrical structure and electronic properties of the neutral RhBn and singly negatively charged RhBn- clusters are obtained in the range of 3 ≤ n ≤ 10 using the unbiased CALYPSO structure search method and density functional theory (DFT). A combination of the PBE0 functional and the def2-TZVP basis set is used for determining global minima on potential energy surfaces of the Rh-doped Bn clusters. The photoelectron spectra of the anions are simulated using the time-dependent density functional theory (TD-DFT) method. Good agreement between our simulated and experimentally obtained photoelectron spectra for RhB9- provides support to the validity of our theoretical method. The relative stabilities of the ground-state RhBn and RhBn- clusters are estimated using the calculated binding energies, second-order total energy differences, and HOMO-LUMO gaps. It is found that RhB7 and RhB8- are the most stable species in the neutral and anionic series, respectively. The chemical bonding analysis reveals that the RhB8-cluster possesses two sets of delocalized σ and π bonds. In both cases, the Hückel 4N + 2 rule is fulfilled and this cluster possesses both σ and π aromaticities.

14.
ACS Nano ; 10(10): 9695-9702, 2016 Oct 25.
Artigo em Inglês | MEDLINE | ID: mdl-27704783

RESUMO

Utilizing individual atoms or molecules as functional units in electronic circuits meets the increasing technical demands for the miniaturization of traditional semiconductor devices. To be of technological interest, these functional devices should be high-yield, consume low amounts of energy, and operate at room temperature. In this study, we developed nanodevices called quantized conductance atomic switches (QCAS) that satisfy these requirements. The QCAS operates by applying a feedback-controlled voltage to a nanoconstriction within a stretched nanowire. We demonstrated that individual metal atoms could be removed from the nanoconstriction and that the removed metal atoms could be refilled into the nanoconstriction, thus yielding a reversible quantized conductance switch. We determined the key parameters for the QCAS between the "on" and "off" states at room temperature under a small operating voltage. By controlling the applied bias voltage, the atoms can be further completely removed from the constriction to break the nanowire, generating single-atom nanogaps. These atomic nanogaps are quite stable under a sweeping voltage and can be readjusted with subangstrom accuracy, thus fulfilling the requirement of both reliability and flexibility for the high-yield fabrication of molecular devices.

15.
Front Plant Sci ; 6: 1202, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26779233

RESUMO

Bamboos are grasses (Poaceae) that are widespread in tropical and subtropical regions. We aimed at exploring water use patterns of four tropical bamboo species (Bambusa vulgaris, Dendrocalamus asper, Gigantochloa atroviolacea, and G. apus) with sap flux measurement techniques. Our approach included three experimental steps: (1) a pot experiment with a comparison of thermal dissipation probes (TDPs), the stem heat balance (SHB) method and gravimetric readings using potted B. vulgaris culms, (2) an in situ calibration of TDPs with the SHB method for the four bamboo species, and (3) field monitoring of sap flux of the four bamboo species along with three tropical tree species (Gmelina arborea, Shorea leprosula, and Hevea brasiliensis) during a dry and a wet period. In the pot experiment, it was confirmed that the SHB method is well suited for bamboos but that TDPs need to be calibrated. In situ, species-specific parameters for such calibration formulas were derived. During field monitoring we found that some bamboo species reached high maximum sap flux densities. Across bamboo species, maximal sap flux density increased with decreasing culm diameter. In the diurnal course, sap flux densities in bamboos peaked much earlier than radiation and vapor pressure deficit (VPD), and also much earlier than sap flux densities in trees. There was a pronounced hysteresis between sap flux density and VPD in bamboos, which was less pronounced in trees. Three of the four bamboo species showed reduced sap flux densities at high VPD values during the dry period, which was associated with a decrease in soil moisture content. Possible roles of internal water storage, root pressure and stomatal sensitivity are discussed.

16.
Nanoscale ; 6(22): 13396-401, 2014 Nov 21.
Artigo em Inglês | MEDLINE | ID: mdl-25271483

RESUMO

A series of fresh molecular junctions at a single molecule level were created and the current fluctuations were studied as electrons passed through them. Our results indicate that telegraph-like current fluctuations at room temperature neither originate from electron trapping/detrapping processes nor from molecule re-conformation. Our results will be helpful in better understanding the mechanism of current fluctuations.

17.
Ying Yong Sheng Tai Xue Bao ; 23(4): 979-84, 2012 Apr.
Artigo em Chinês | MEDLINE | ID: mdl-22803463

RESUMO

Based on the validation of Granier's empirical formula for calculating tree stem sap flux density, a comparative study was conducted on the measurement of Bambusa chungi sap flow by using different lengths of thermal dissipation probe (TDP), aimed to approach the applicability of TDP in measuring the sap flow of B. chungii. The difference in the daily change of the sap flow between B. chungii and nearby growing Schima superb was also analyzed. Because of the thinner bamboo wall and the heterogeneous anatomy, the sap flux density of B. chungii measured by 10 mm long probe could be underestimated, but that measured by 8 and 5 mm long probes could be relatively accurate. The comparison of the sap flow between B. chungii and nearby growing S. superba revealed that both the mean sap flux density and its daily change pattern' s skewness of B. chungii were higher than those of S. superba, but the nighttime sap flow of B. chungii was less than that of S. superba, indicating that the water recharge of B. chungii during nighttime was less active than that of S. superba. It was suggested that using TDP to investigate the sap flow of bamboo would be feasible, but careful calibration would be required before the TDP was put into application on different bamboo species.


Assuntos
Bambusa/fisiologia , Técnicas de Química Analítica/instrumentação , Transpiração Vegetal/fisiologia , Água/metabolismo , Bambusa/metabolismo , Caules de Planta/metabolismo , Caules de Planta/fisiologia
18.
J Nurs Res ; 19(3): 220-9, 2011 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-21857329

RESUMO

BACKGROUND: : Nursing shortage is a critical problem worldwide. Using nurse aides (NAs) within a skill mix model has been applied in the healthcare delivery system as a strategy to improve nursing workforce shortages. PURPOSE: : The purpose of this study was to investigate changes in nurse perceptions of their role functions under the skill mix model in Taiwan. METHODS: : This was a cross-sectional designed study that employed a structured questionnaire. Participants included 38 registered nurses from three medical wards in three hospitals that had implemented the skill mix model for 6 months. The questionnaire gathered data on participant demographics, perceptions on the role functions, role and job satisfaction of nurses, and patient care quality. Nurses' role functions were grouped into independent, dependent, and interdependent categories. RESULTS: : Results demonstrate that nurses' perceptions of independent and interdependent role function have changed since the implementation of the skill mix model. The most significant role changes in the independent function category included the nurse as educator of NAs, supervisor for patient care, and evaluator for nursing care outcomes. The most significant role changes in the interdependent function category included the nurse as integrator of nursing work and coordinator of the healthcare team. Nurses' perceived changes increase in repetitive confirmation of patient conditions and patient care quality. CONCLUSIONS: : This study revealed that nurses working in skill mix model environments need more authority to delegate and educate NAs and to supervise and integrate nursing care. Study results may serve as a reference for hospital nursing practice in Taiwan.


Assuntos
Competência Clínica , Modelos de Enfermagem , Papel do Profissional de Enfermagem , Estudos Transversais , Taiwan
19.
Ying Yong Sheng Tai Xue Bao ; 21(10): 2457-64, 2010 Oct.
Artigo em Chinês | MEDLINE | ID: mdl-21328929

RESUMO

The eigenvalues of continuous sap flow pattern, i. e. , skewness and kurtosis, were used to investigate the water usage of Schima superba with different diameter at breast height (DBH), and the method of normalization was firstly applied to eliminate the effects of strong affecting factor (photosynthetic active radiation, PAR) to explore the possible relationship between weak affecting factor (soil moisture) and sap flow. Generally, the trees with larger DBH had smaller skewness of sap flux density and later-appeared but larger peak values, suggesting that much more water was transpired, and the larger trees showed smaller skewness and later-appeared larger peak values in wet season than in dry season, suggesting that more water was transpired in wet season. On the other hand, smaller trees had lesser differences in the skewness between dry and wet seasons, suggesting that there was no significant difference in the transpiration between the two seasons. The relationship between individual tree's transpiration and soil moisture was significant and positive after the two parameters being normalized with PAR peak values. When the soil moisture content was higher, the transpiration of the trees with larger DBH was steadily increasing with soil moisture, while that of the trees with moderate or smaller DBH had opposite trend, presumably due to their transpiration and water absorption were approached to the limit.


Assuntos
Caules de Planta/anatomia & histologia , Transpiração Vegetal , Solo/análise , Theaceae/metabolismo , Água/análise , Matemática , Theaceae/anatomia & histologia
20.
Hu Li Za Zhi ; 56(3): 66-71, 2009 Jun.
Artigo em Chinês | MEDLINE | ID: mdl-19472114

RESUMO

For many years assistant personnel have been an integral part of Taiwan's healthcare system, assisting nurses to take care of patients and helping out with various aspects of unit work. The skill-mixed model was discussed during the period of greatest SARS risk in Taiwan, when the tradition of family accompaniment in hospitals presented a real and present risk of nosocomial cross-infection. Since 2003, health care authorities have continued to attempt to implement an appropriate nursing model to improve overall delivery of healthcare. The nursing model implementation in Taiwan is similar to the skill-mixed model deployed in Western countries. Therefore, this article introduces the origin, definition, purpose and categories of the skill-mixed model, as well as related studies on the impact of the skill-mixed model on nursing and patient care outcomes. The article will further explore the current situation and difficulties of applying the skill-mixed model in Taiwan. This article can serve as a reference for health policy makers and be used to help improve Taiwan's healthcare delivery system.


Assuntos
Modelos de Enfermagem , Papel do Profissional de Enfermagem , Assistentes de Enfermagem/educação , Taiwan
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