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1.
Wiad Lek ; 72(11 cz 1): 2082-2084, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31860850

RESUMO

OBJECTIVE: Introduction: Hyperuricemia is an independent risk factor for high-normal blood pressure (BP) both in men and women. The effect of uric acid (UA) on erythrocyte morphology in normotensive patients needs further study. The aim - to evaluate the impact of serum UA level on erythrocyte morphology in normotensive patients. PATIENTS AND METHODS: Materials and methods: Patients were divided into two group according to the UA level: the first group - 38 patients with UA level < 400 mcmol/L; the second group - 42 patients with UA level ≥ 400 mcmol/L. Studies on erythrocyte morphology were conducted using cytological analysis and scanning electron microscopy. RESULTS: Results: Patients of the 1st group had poikilocytosis level of 4,6%, while type I echinocytes were 3,2%, type II echinocytes - 1,1%, stomatocytes - 1,3%. In the 2nd group, poikilocytosis exceeding 5% was observed in 12 patients with mean values of altered shapes of 12,8±1,2%. In the 2nd group, type I echinocytes was 6,2% (9,4±0,9%) more, type II echinocytes - 1,3% (2,4±0,5%) more, stomatocytes - 0,3% (1,0±0,2%) more. In the study correlation between UA and poikilocytosis was found: in the 1st group - r = +0,21 and in the second group - r = +0,42. In the 1st group, correlation between UA and BP was moderate for SBP - r = +0,34 and weak for DBP - r = +0,29; in the 2nd group: SBP - r = +0,49 and r = +0,35 for DBP. CONCLUSION: Conclusions: Direct correlation between uric acid level and poikilocytosis level becomes more intensive when uric acid level exceeds ≥ 400 mcmol/L.


Assuntos
Eritrócitos , Pressão Sanguínea , Feminino , Humanos , Hipertensão , Hiperuricemia , Masculino , Ácido Úrico
2.
Wiad Lek ; 72(9 cz 2): 1723-1726, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31622254

RESUMO

OBJECTIVE: Introduction: Chronic hyperglycemia as the main link in DM pathogenesis leads to systemic vessels and nerves lesion with chronic bone complications development consequently. The aim: To evaluate influence of hyperglycemia on reparative osteogenesis after perforated tibial fracture in rats. PATIENTS AND METHODS: Materials and methods: A total of 30 white adult rats were subdivided into two groups: 15 healthy rats in Group 1 (control) and 15 rats with alloxan induced hyperglycemia in Group 2 (investigated) and were carried out of experiment on the 10th, 20th and 30th day after the fracture. Hyperglycemia in rats was verificated as the postprandial glycemic rate ≥ 8,0 mmol/l. Tibia diaphysis fracture was modeled by a cylindrical defect with a diameter of 2 mm with portable frezer. Morphological evaluation. A complex morphological studies included histological, morphometric and immunohistochemical examination. RESULTS: Results: This is confirmed by an increase in MMP-9 expression in connective tissue, a decrease in TGF-ß expression in all phases, an increase in the expression of CD3 and CD20 and a marked decrease in the expression of all vascular markers. During hyperglycemia, incomplete blood supply to the tissues occurs, necrosis of bone and soft tissues develop in the area of the fracture, the reparative reaction slows down considerably and manifests itself in the development of fibrous and, less commonly, cartilage tissue. CONCLUSION: Conclusions: In hyperglycemia rats, there was a delay in the callus formation, a decrease in proliferation and ossification, and a slowdown in the processes of angiogenesis.


Assuntos
Diabetes Mellitus/fisiopatologia , Osteogênese , Fraturas da Tíbia/complicações , Animais , Antígenos CD20/metabolismo , Osso e Ossos , Calo Ósseo , Complexo CD3/metabolismo , Modelos Animais de Doenças , Metaloproteinase 9 da Matriz/metabolismo , Neovascularização Fisiológica , Ratos , Fator de Crescimento Transformador beta/metabolismo
3.
Wiad Lek ; 71(7): 1310-1315, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30448802

RESUMO

OBJECTIVE: Introduction: Uric acid (UA) is the risk factors for the development of arterial hypertension (AH). Development of alternative methods of UA level reduction becomes relevant. The aim - to determine the correlation between UA and endothelial dysfunction and blood pressure level (BP), and to evaluate the effectiveness of low level laser therapy (LLLT). PATIENTS AND METHODS: Material and methods: Patients were divided according to the BP level: the first group included 30 patients with the hyperuricemia and normal BP; the second group - 34 patients with hyperuricemia and AH. Endothelium function was evaluated by test with reactive hyperemia. LLLT was provided by using of the apparatus "Mustang-2000" with wavelength 635 nm. RESULTS: Results: There is a mean value negative correlation on the Chaddock's scale r = - 0,6209 between UA and ED; a mean value positive correlation r = 0,48 between UA and daySBP; a weak positive correlation r = 0,33 between UA and DayDBP. LLLT reduces UA level by 4,7% more effective in patients with hyperuricemia without AH than in patients with AH combined with hyperuricemia. LLLT can increase EDVD by 9,87%, reduce UA level by 15,4%, DaySBP and DayDBP - about 7% in patients with AH combined with hyperuricemia than in patients with hyperuricemia along. CONCLUSION: Conclusion: Decreasing of DayDBP in hyperuricemia group and both DaySBP and DayDBP in the group of patients with AH combined with hyperuricemia demonstrated the influence of UA on EDVD and AH and the possibility to correct these cardiovascular risk factors with the using of LLLT.


Assuntos
Hipertensão/terapia , Hiperuricemia/terapia , Terapia com Luz de Baixa Intensidade , Humanos , Fatores de Risco , Ácido Úrico/sangue
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