Intraoral primary syphilis mimicking lymphoproliferative disorder.

Syphilis can mimic, clinically and microscopically, many other diseases. By microscopy, typically syphilis presents with plasma cell infiltration, admixed with lymphocytes and macrophages, in lichenoid and/or perivascular/perineural distribution pattern. When exuberant, this inflammatory infiltrate can mimic a lymphoproliferative disorder (LPD), notably plasma cell neoplasia or lymphoma. To date, about 12 cases of secondary syphilis, all but one in extraoral location, suggesting initially a LPD, have been published. Here, to our knowledge, we report an unusual case of intraoral primary syphilis initially suggesting LPD, notably lymphoid hyperplasia (pseudolymphoma); however, mucosa-associated lymphoid tissue (MALT) lymphoma and follicular lymphoma could not be disregarded. Polyclonality of plasma cells on immunohistochemistry, in strict clinical correlation, was essential to arrive at the correct diagnosis.

Lip Granular Cell Tumor (GCT) in a Pediatric Patient: Critical Literature Review on Pediatric Intraoral GCT and Acquired and Congenital Intraoral Non-Neural GCT.

Granular cell tumor (GCT) is an uncommon benign neoplasm derived from Schwann cells, frequently affecting the oral cavity, skin, and gastrointestinal tract. On microscopy, pseudocarcinomatous squamous hyperplasia (PSH) and perineural involvement are potential diagnostic pitfalls. GCT should be differentiated from non-neural GCT (NN-GCT). A 13-year-old male patient was referred presenting a nodular lesion on the upper lip several months ago. After excisional biopsy, microscopy revealed GCT without PSH but presenting multifocal perineural involvement. By immunohistochemistry, ALK was negative, whereas Rb and INI1 expression was intact. Moreover, with few intraoral NN-GCTs being assessed, recent studies suggest that acquired dermal NN-GCT subgroup seems to correspond to ALK-rearranged variants of epithelioid fibrous histiocytoma. Accordingly, further research on this topic is strongly encouraged.

Radiolucent image in lower third molar: hidden caries or pre-eruptive resorption?: a case report / Imagem radiolucente em terceiro molar inferior: cárie oculta ou reabsorção pré-eruptiva?: um relato de caso

ABSTRACT Caries is a multifactorial disease due to the imbalance of the de/re-mineralization process. Complementary radiographic examinations are able to detect hidden caries. The purpose of this short communication was to investigate the radiolucent image suggestive of hidden caries in lower third molar. The extraction of the tooth, decalcification, inclusion and preparation were performed for histological analysis of the lesion. Histological findings revealed a pre-eruptive resorption, and the etiological factors of this coronary resorption were undefined. The professional should be aware of the occurrences of these lesions to early diagnose and propose appropriate treatment to avoid future complications to the patient.

RESUMO A cárie é conceituada como uma doença multifatorial condicionada ao desequilíbrio no processo de desmineralização e remineralização das estruturas dentárias. O propósito desse trabalho foi investigar a imagem radiolúcida sugestiva de cárie oculta em terceiro molar. Foi realizado a exodontia do elemento dentário, descalcificação e confecção de lâminas para posterior estudo histológico da lesão. O achado histológico conclui-se tratar de uma reabsorção pré-eruptiva. O profissional deve estar atento às ocorrências dessas lesões para diagnosticar precocemente e propor o tratamento adequado, evitando complicações futuras ao paciente.

Reabilitação Oral com Prótese Obturadora em Comunicação Buconasal após Ocorrência de Carcinoma de Células Escamosas: Relato de Caso / Oral Rehabilitation with Filling Prosthesis in Bucconasal Communication after the Occurrence of Squamous Cell Carcinoma: Case Report / Rehabilitación Oral con Prótesis Obturatriz en Comunicación Oral tras la Aparición de Carcinoma Epidermoide: Reporte de Caso

Introdução: O tratamento de neoplasia maligna pode consistir em ampla excisão cirúrgica. Em alguns casos, em razão do tratamento agressivo na remoção do tumor, há grande comprometimento das estruturas intrabucais. Assim, próteses são utilizadas para a obturação da cavidade maxilar, possibilitando a reconstrução da região afetada, juntamente com a reabilitação oral. Relato do caso: Paciente de 53 anos de idade, sexo feminino, ex-tabagista e ex-etilista, apresentou diagnóstico de carcinoma de células escamosas na região de palato mole, sendo necessária cirurgia de ressecção transoral associada à radioterapia. Após aproximadamente um ano, a paciente retornou com nova lesão em palato, que novamente evidenciou carcinoma de células escamosas, sendo necessária nova cirurgia de ressecção transoral. Após dois anos, a paciente retornou ao Departamento de Odontologia a fim de receber o tratamento reabilitador, pois a prótese parcial removível superior era provisória, não substituía todos os dentes ausentes e não obtinha adaptação adequada à comunicação buconasal. Foi realizado tratamento reabilitador definitivo com prótese parcial removível superior e com prótese total no rebordo residual inferior. Conclusão: A necessidade do acompanhamento odontológico nos casos de ocorrência de carcinoma de células escamosas oral bem como a importância do tratamento reabilitador e suas técnicas contribuem para a autoestima e a qualidade de vida do paciente

Introduction: The treatment of malignant neoplasm may consist in extensive surgical excision. In some cases, due to aggressive treatment in the removal of the tumor, intraoral structures are strongly compromised. Thus, prostheses are used to fill the maxillary cavity, allowing reconstruction of the affected region, together with oral rehabilitation. Case report: A 53-year-old female patient, ex-smoker and ex-alcoholic was diagnosed with squamous cell carcinoma in the soft palate region, requiring transoral resection surgery associated with radiotherapy. After approximately one year, the patient returned with a new palatal lesion, also diagnosed as squamous cell carcinoma, requiring further transoral resection surgery. After two years, the patient returned to the Dentistry Department to receive the rehabilitative treatment, as she had only a temporary removable upper partial denture, where all the missing teeth were not replaced and there was poor adaptation to bucconasal communication. A final rehabilitative treatment was performed with upper partial removable denture and total prosthesis in the inferior residual ridge. Conclusion: The need for dental follow-up in cases of oral squamous cell carcinoma as well as the importance of rehabilitation treatment and its techniques contribute for the patient's self-esteem and quality of life

Introducción: El tratamiento de las neoplasias malignas puede consistir en una exéresis quirúrgica extensa. En algunos casos, debido a un tratamiento agresivo para extirpar el tumor, existe un gran compromiso de las estructuras intraorales. Así, las prótesis se utilizan para rellenar la cavidad maxilar, permitiendo la reconstrucción de la región afectada, junto con la rehabilitación oral. Relato del caso: Paciente femenina de 53 años, exfumadora y exalcohólica, que presentó el diagnóstico de carcinoma epidermoide en la región del paladar blando, que requirió cirugía de resección transoral asociada a radioterapia. Después de aproximadamente un año, la paciente regresó con una nueva lesión en el paladar, en la que también se le diagnosticó un carcinoma epidermoide, requiriendo una nueva cirugía de resección transoral. A los dos años, la paciente volvió al Departamento de Odontología para recibir tratamiento rehabilitador, ya que la prótesis parcial superior removible era temporal, no reponía todos los dientes faltantes y no obtenía una adecuada adaptación a la comunicación bucconasal. El tratamiento de rehabilitación definitivo se realizó con una dentadura postiza parcial removible superior y una dentadura total en el reborde residual inferior. Conclusión: La necesidad de seguimiento odontológico en los casos de carcinoma epidermoide oral así como la importancia del tratamiento rehabilitador y sus técnicas contribuyen a la autoestima y calidad de vida del paciente

Multiple Desmoplastic Cellular Neurothekeomas in Child: Report of the First Oral Case and Review of the Literature.

Cellular neurothekeomas (CNs) are distinctive benign tumors of uncertain histogenesis, with predilection for the skin of the head and neck region. We describe the first case of multiple desmoplastic CNs (DCNs) affecting the oral cavity in a 9-year-old girl. Histopathologic evaluation showed a proliferation of spindle and epithelioid cells, forming nests and bundles, supported by exuberant fibrous stroma, as well as scattered multinucleated floret-like giant cells. The tumor cells were immunopositive for vimentin, CD63, CD56, whereas AE1/AE3, S100, CD34, α-SMA, GFAP, EMA, CD57 and NSE were negative. Ki-67 was <2%. Multiple DCNs should be considered in the differential diagnosis of oral nodular lesions.

Exclusive Primary Lesion of Oral Leishmaniasis with Immunohistochemical Diagnosis.

A case of oral leishmaniasis without cutaneous involvement affecting the upper alveolar ridge mucosa/gingiva and the hard palate is reported in a 41-year-old Brazilian man. Microscopic examination disclosed scarce amastigotes and the definitive diagnosis was facilitated by immunohistochemical analysis. The clinical presentation of this lesion is unusual and underlies the importance of considering leishmaniasis in the differential diagnosis of oral lesions, especially in endemic areas. A literature review of the cases of mucosal leishmaniasis with exclusive primary lesions of the oral mucosa was also performed.

FASN expression, angiogenesis and lymphangiogenesis in central and peripheral giant cell lesions

Central giant cell lesion (CGCL) and peripheral giant cell lesion (PGCL) are non-neoplastic proliferative processes of the jaws. PGCL is a reactive process induced by irritant local factors and CGCL is an intra-osseous lesion of unknown etiology. Both lesions exhibit similar histologic features showing abundant mononuclear cells, admixed with a large number of multinucleated giant cells and a rich vascularized stroma with extravasated erythrocytes, hemosiderin deposition, and blood-filled pools. Recent studies have linked fatty acid synthase (FASN) with angiogenesis. Objective: To evaluate angiogenesis and lymphangiogenesis and their relationship with FASN expression in CGCL and PGCL. Material and Methods: Thirteen CGCL and 14 PGCL of the jaws were selected for immunoexpression of FASN; CD34 and CD105 (to assess blood microvessel density [MVD] and microvessel area [MVA]); and D2-40 (to assess lymphatic MVD and MVA). Results: Within PGCL and CGCL, MVD-CD34 was signifcantly higher than MVD-CD10S, followed by MVD-D2-40. Moreover, a signifcantly higher number of FASN-positive multinucleated giant cells than mononuclear cells were observed. Between PGCL and CGCL, only MVD-CD34 and all MVA were signifcantly higher in PGCL. Positive correlation between MVA-CD10S with FASNpositive mononuclear cells in both lesions was observed. Conclusions: Our results show both lesions exhibiting similar levels of FASN expression and neoangiogenesis, suggesting constitutive processes that regulate tissue maintenance. .

FASN expression, angiogenesis and lymphangiogenesis in central and peripheral giant cell lesions.

UNLABELLED: Central giant cell lesion (CGCL) and peripheral giant cell lesion (PGCL) are non-neoplastic proliferative processes of the jaws. PGCL is a reactive process induced by irritant local factors and CGCL is an intra-osseous lesion of unknown etiology. Both lesions exhibit similar histologic features showing abundant mononuclear cells, admixed with a large number of multinucleated giant cells and a rich vascularized stroma with extravasated erythrocytes, hemosiderin deposition, and blood-filled pools. Recent studies have linked fatty acid synthase (FASN) with angiogenesis. OBJECTIVE: To evaluate angiogenesis and lymphangiogenesis and their relationship with FASN expression in CGCL and PGCL. MATERIAL AND METHODS: Thirteen CGCL and 14 PGCL of the jaws were selected for immunoexpression of FASN; CD34 and CD105 (to assess blood microvessel density [MVD] and microvessel area [MVA]); and D2-40 (to assess lymphatic MVD and MVA). RESULTS: Within PGCL and CGCL, MVD-CD34 was signifcantly higher than MVD-CD10S, followed by MVD-D2-40. Moreover, a signifcantly higher number of FASN-positive multinucleated giant cells than mononuclear cells were observed. Between PGCL and CGCL, only MVD-CD34 and all MVA were signifcantly higher in PGCL. Positive correlation between MVA-CD10S with FASNpositive mononuclear cells in both lesions was observed. CONCLUSIONS: Our results show both lesions exhibiting similar levels of FASN expression and neoangiogenesis, suggesting constitutive processes that regulate tissue maintenance.

Hard palate hyperpigmentation secondary to chronic chloroquine therapy: report of five cases.

Antimalarials are commonly prescribed in medical practice for conditions such as rheumatoid arthritis, lupus erythematosus, as well as malaria. They are generally well-tolerated, but side effects, although infrequent, are well known. The antimalarial chloroquine diphosphate may be associated with a bluish-gray to black hyperpigmentation of the oral mucosa, mainly on the hard palate. In this report we described five additional cases of palate hyperpigmentation related to the chronic use of chloroquine diphosphate. Professionals must be aware of the adverse effects of antimalarials as chloroquine diphosphate in order to make the correct diagnosis and appropriate management of the patient. Early diagnosis of oral pigmentation by antimalarials may be of great relevance, because it might be an early sign of ocular involvement, and therefore it may be helpful to prevent further complications of antimalarial therapy for the patient.

Central granular cell odontogenic tumor: a histopathologic and immunohistochemical study.

The central granular cell odontogenic tumor (CGCOT) is a rare lesion that usually affects the posterior region of the mandible of young adults. We present a case of CGCOT involving the mandible of a 20-year-old white woman, emphasizing the immunohistochemical characteristics using a large panel of antibodies. The lesion was removed surgically, and after 4 years of follow-up, there are no evidences of recurrences. The odontogenic epithelium (OE) showed positivity for cytokeratins (CKs) AE1/AE3, 34betaE12, CK5, CK7, CK8, CK14, CK19, E-cadherin, beta-catenin, CD138, and p63. The granular cells were positive for vimentin, CD68, lysozyme, muscle-specific actin, alpha-smooth muscle actin, calponin, neuron-specific enolase (NSE), CD138, and bcl-2. Dendritic-like cells surrounding the OE displayed positivity for vimentin, CD1a, S100, CD68, and bcl-2, but it was negative for factor XIIIa, supporting a Langerhans cell phenotype. Ki-67 labeling index was 1.8%, whereas p53 was negative. These data confirm the benign nature of CGCOT, the association of OE with Langerhans cells, and a variable phenotype of the granular cells.

Estudo das alterações morfológicas causadas pela uretana em modelo de carcinogênese bucal DMBA-induzida / The study of morphologic changes induced by urethana in an oral chemical carcinogenesis DMBA-induced model

A proposta desse trabalho resultou da necessidade de reavaliar o potencial carcinogênico da uretana, em concentrações mais baixas, a partir do modelo experimental de carcinogênese bucal DMBA-induzida. Cem hamsters sírios dourados foram separados em cinco grupos experimentais. O grupo 1 recebeu aplicações tópicas de uretana 0,5 por cento na borda lateral da língua; grupo 2, uretana 6 por cento; grupo 3 uretana 0,5 por cento + DMBA, e o grupo 5- DMBA (controle positivo). Os dados obtidos mostraram que a uretana a 0,5 por cento e 6 por cento não induziu alterações histolíticas nos grupos 1 e 2. A formação de carcinomas nos animais tratados com uretana e DMBA ocorreu em proporções menores quando comparado com o grupo controle positivo (DMBA). A uretana a 0,5 por cento e 6 por cento reduziu a carcinogenicidade do DMBA, e não apresentou potencial carcinogênico de iniciação, promoção e/ou progressão

Neurilemoma no lábio inferior / Neurilemmoma in lower lip

Um caso clínico de neurilemoma em lábio inferior é descrito, destacando suas características clínicas, bem como seu aspecto microscópico. Terminologia, aspectos ultra-estruturais e estudos imunohistoquímicos realizados nesse tumor säo discutidos. A importância deste caso se deve à localizaçäo näo muito comum, no lábio inferior, e ao fato de que, apesar de ser raro, o neurilemoma deve ser lembrado no diagnóstico clínico diferencial dos tumores das glândulas salivares e do fibroma traumático