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1.
Head Neck Pathol ; 12(1): 75-81, 2018 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-28597210

RESUMO

Cellular neurothekeomas (CNs) are distinctive benign tumors of uncertain histogenesis, with predilection for the skin of the head and neck region. We describe the first case of multiple desmoplastic CNs (DCNs) affecting the oral cavity in a 9-year-old girl. Histopathologic evaluation showed a proliferation of spindle and epithelioid cells, forming nests and bundles, supported by exuberant fibrous stroma, as well as scattered multinucleated floret-like giant cells. The tumor cells were immunopositive for vimentin, CD63, CD56, whereas AE1/AE3, S100, CD34, α-SMA, GFAP, EMA, CD57 and NSE were negative. Ki-67 was <2%. Multiple DCNs should be considered in the differential diagnosis of oral nodular lesions.


Assuntos
Neoplasias Bucais/patologia , Neoplasias Primárias Múltiplas/patologia , Neurotecoma/patologia , Biomarcadores Tumorais/análise , Criança , Feminino , Humanos
2.
Head Neck Pathol ; 10(4): 533-537, 2016 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-27260217

RESUMO

A case of oral leishmaniasis without cutaneous involvement affecting the upper alveolar ridge mucosa/gingiva and the hard palate is reported in a 41-year-old Brazilian man. Microscopic examination disclosed scarce amastigotes and the definitive diagnosis was facilitated by immunohistochemical analysis. The clinical presentation of this lesion is unusual and underlies the importance of considering leishmaniasis in the differential diagnosis of oral lesions, especially in endemic areas. A literature review of the cases of mucosal leishmaniasis with exclusive primary lesions of the oral mucosa was also performed.


Assuntos
Leishmaniose/diagnóstico , Doenças da Boca/diagnóstico , Adulto , Humanos , Imuno-Histoquímica , Masculino , Mucosa Bucal/parasitologia , Palato Duro/parasitologia
3.
J. appl. oral sci ; 22(2): 131-137, Mar-Apr/2014. tab, graf
Artigo em Inglês | LILACS | ID: lil-704194

RESUMO

Central giant cell lesion (CGCL) and peripheral giant cell lesion (PGCL) are non-neoplastic proliferative processes of the jaws. PGCL is a reactive process induced by irritant local factors and CGCL is an intra-osseous lesion of unknown etiology. Both lesions exhibit similar histologic features showing abundant mononuclear cells, admixed with a large number of multinucleated giant cells and a rich vascularized stroma with extravasated erythrocytes, hemosiderin deposition, and blood-filled pools. Recent studies have linked fatty acid synthase (FASN) with angiogenesis. Objective: To evaluate angiogenesis and lymphangiogenesis and their relationship with FASN expression in CGCL and PGCL. Material and Methods: Thirteen CGCL and 14 PGCL of the jaws were selected for immunoexpression of FASN; CD34 and CD105 (to assess blood microvessel density [MVD] and microvessel area [MVA]); and D2-40 (to assess lymphatic MVD and MVA). Results: Within PGCL and CGCL, MVD-CD34 was signifcantly higher than MVD-CD10S, followed by MVD-D2-40. Moreover, a signifcantly higher number of FASN-positive multinucleated giant cells than mononuclear cells were observed. Between PGCL and CGCL, only MVD-CD34 and all MVA were signifcantly higher in PGCL. Positive correlation between MVA-CD10S with FASNpositive mononuclear cells in both lesions was observed. Conclusions: Our results show both lesions exhibiting similar levels of FASN expression and neoangiogenesis, suggesting constitutive processes that regulate tissue maintenance. .


Assuntos
Adolescente , Adulto , Feminino , Humanos , Masculino , Adulto Jovem , Ácido Graxo Sintase Tipo I/análise , Células Gigantes/patologia , Doenças Maxilomandibulares/patologia , Linfangiogênese/fisiologia , Neovascularização Patológica/patologia , Antígenos CD/análise , /análise , Biópsia , Imuno-Histoquímica , Microvasos/patologia , Estudos Retrospectivos , Receptores de Superfície Celular/análise , Estatísticas não Paramétricas
4.
J Appl Oral Sci ; 22(2): 131-7, 2014 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-24676584

RESUMO

UNLABELLED: Central giant cell lesion (CGCL) and peripheral giant cell lesion (PGCL) are non-neoplastic proliferative processes of the jaws. PGCL is a reactive process induced by irritant local factors and CGCL is an intra-osseous lesion of unknown etiology. Both lesions exhibit similar histologic features showing abundant mononuclear cells, admixed with a large number of multinucleated giant cells and a rich vascularized stroma with extravasated erythrocytes, hemosiderin deposition, and blood-filled pools. Recent studies have linked fatty acid synthase (FASN) with angiogenesis. OBJECTIVE: To evaluate angiogenesis and lymphangiogenesis and their relationship with FASN expression in CGCL and PGCL. MATERIAL AND METHODS: Thirteen CGCL and 14 PGCL of the jaws were selected for immunoexpression of FASN; CD34 and CD105 (to assess blood microvessel density [MVD] and microvessel area [MVA]); and D2-40 (to assess lymphatic MVD and MVA). RESULTS: Within PGCL and CGCL, MVD-CD34 was signifcantly higher than MVD-CD10S, followed by MVD-D2-40. Moreover, a signifcantly higher number of FASN-positive multinucleated giant cells than mononuclear cells were observed. Between PGCL and CGCL, only MVD-CD34 and all MVA were signifcantly higher in PGCL. Positive correlation between MVA-CD10S with FASNpositive mononuclear cells in both lesions was observed. CONCLUSIONS: Our results show both lesions exhibiting similar levels of FASN expression and neoangiogenesis, suggesting constitutive processes that regulate tissue maintenance.


Assuntos
Ácido Graxo Sintase Tipo I/análise , Células Gigantes/patologia , Doenças Maxilomandibulares/patologia , Linfangiogênese/fisiologia , Neovascularização Patológica/patologia , Adolescente , Adulto , Antígenos CD/análise , Antígenos CD34/análise , Biópsia , Endoglina , Feminino , Humanos , Imuno-Histoquímica , Masculino , Microvasos/patologia , Receptores de Superfície Celular/análise , Estudos Retrospectivos , Estatísticas não Paramétricas , Adulto Jovem
5.
J Cutan Pathol ; 40(9): 833-8, 2013 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-23782298

RESUMO

Antimalarials are commonly prescribed in medical practice for conditions such as rheumatoid arthritis, lupus erythematosus, as well as malaria. They are generally well-tolerated, but side effects, although infrequent, are well known. The antimalarial chloroquine diphosphate may be associated with a bluish-gray to black hyperpigmentation of the oral mucosa, mainly on the hard palate. In this report we described five additional cases of palate hyperpigmentation related to the chronic use of chloroquine diphosphate. Professionals must be aware of the adverse effects of antimalarials as chloroquine diphosphate in order to make the correct diagnosis and appropriate management of the patient. Early diagnosis of oral pigmentation by antimalarials may be of great relevance, because it might be an early sign of ocular involvement, and therefore it may be helpful to prevent further complications of antimalarial therapy for the patient.


Assuntos
Antimaláricos/efeitos adversos , Cloroquina/efeitos adversos , Hiperpigmentação , Palato Duro/patologia , Idoso de 80 Anos ou mais , Antimaláricos/administração & dosagem , Cloroquina/administração & dosagem , Feminino , Humanos , Hiperpigmentação/induzido quimicamente , Hiperpigmentação/patologia , Masculino , Pessoa de Meia-Idade
6.
Ann Diagn Pathol ; 13(6): 405-12, 2009 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-19917479

RESUMO

The central granular cell odontogenic tumor (CGCOT) is a rare lesion that usually affects the posterior region of the mandible of young adults. We present a case of CGCOT involving the mandible of a 20-year-old white woman, emphasizing the immunohistochemical characteristics using a large panel of antibodies. The lesion was removed surgically, and after 4 years of follow-up, there are no evidences of recurrences. The odontogenic epithelium (OE) showed positivity for cytokeratins (CKs) AE1/AE3, 34betaE12, CK5, CK7, CK8, CK14, CK19, E-cadherin, beta-catenin, CD138, and p63. The granular cells were positive for vimentin, CD68, lysozyme, muscle-specific actin, alpha-smooth muscle actin, calponin, neuron-specific enolase (NSE), CD138, and bcl-2. Dendritic-like cells surrounding the OE displayed positivity for vimentin, CD1a, S100, CD68, and bcl-2, but it was negative for factor XIIIa, supporting a Langerhans cell phenotype. Ki-67 labeling index was 1.8%, whereas p53 was negative. These data confirm the benign nature of CGCOT, the association of OE with Langerhans cells, and a variable phenotype of the granular cells.


Assuntos
Biomarcadores Tumorais/metabolismo , Tumor de Células Granulares/metabolismo , Neoplasias Mandibulares/metabolismo , Tumores Odontogênicos/metabolismo , Intervalo Livre de Doença , Feminino , Tumor de Células Granulares/patologia , Tumor de Células Granulares/cirurgia , Humanos , Imuno-Histoquímica , Neoplasias Mandibulares/patologia , Neoplasias Mandibulares/cirurgia , Tumores Odontogênicos/patologia , Tumores Odontogênicos/cirurgia , Adulto Jovem
7.
Rev. Fac. Odontol. Porto Alegre ; 44(1): 31-35, jul. 2003. ilus, tab
Artigo em Português | LILACS, BBO - Odontologia | ID: lil-400754

RESUMO

A proposta desse trabalho resultou da necessidade de reavaliar o potencial carcinogênico da uretana, em concentrações mais baixas, a partir do modelo experimental de carcinogênese bucal DMBA-induzida. Cem hamsters sírios dourados foram separados em cinco grupos experimentais. O grupo 1 recebeu aplicações tópicas de uretana 0,5 por cento na borda lateral da língua; grupo 2, uretana 6 por cento; grupo 3 uretana 0,5 por cento + DMBA, e o grupo 5- DMBA (controle positivo). Os dados obtidos mostraram que a uretana a 0,5 por cento e 6 por cento não induziu alterações histolíticas nos grupos 1 e 2. A formação de carcinomas nos animais tratados com uretana e DMBA ocorreu em proporções menores quando comparado com o grupo controle positivo (DMBA). A uretana a 0,5 por cento e 6 por cento reduziu a carcinogenicidade do DMBA, e não apresentou potencial carcinogênico de iniciação, promoção e/ou progressão


Assuntos
Animais , Carcinógenos , Neoplasias Bucais , Uretana
8.
BCI ; 9(34): 145-149, abr.-jun. 2002. ilus
Artigo em Português | LILACS, BBO - Odontologia | ID: lil-321856

RESUMO

Um caso clínico de neurilemoma em lábio inferior é descrito, destacando suas características clínicas, bem como seu aspecto microscópico. Terminologia, aspectos ultra-estruturais e estudos imunohistoquímicos realizados nesse tumor säo discutidos. A importância deste caso se deve à localizaçäo näo muito comum, no lábio inferior, e ao fato de que, apesar de ser raro, o neurilemoma deve ser lembrado no diagnóstico clínico diferencial dos tumores das glândulas salivares e do fibroma traumático


Assuntos
Humanos , Masculino , Adulto , Imuno-Histoquímica , Lábio , Neurilemoma , Cálculos das Glândulas Salivares
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