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1.
Med Oral Patol Oral Cir Bucal ; 25(4): e468-e473, 2020 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-32388528

RESUMO

BACKGROUND: This study compared three different concentrations of EO (1.25%, 2.5% and 5%) for the treatment of oral vascular anomalies (OVAs). MATERIAL AND METHODS: This was a retrospective comparative analysis of patients with OVAs treated with EO. Anomalies smaller than 20 mm were included. The patients were treated with 1.25% (G1), 2.5% (G2), and 5% (G3) and clinical data were obtained. The number of sessions, the final volume and dose of EO were statistically analyzed to verify effectiveness and safety of the treatment. The different concentrations of EO were compared considering the number of sessions, the final volume and total dose of EO. Analysis of covariance (ANCOVA) was used to evaluate the influence of covariates on the outcomes. A p-value < 0.05 was considered significant. RESULTS: Nineteen women and 11 men with a median age of 54 years were included. The OVAs were most frequent in the lip (n=14) and cheek (n=9). All lesions exhibited complete clinical healing within 28 days. Patients of G3 required fewer sessions than those of G2 (p=0.017), a lower final volume compared to the other groups (p<0.001), and a lower total dose than G1 (p<0.001). Patients of G1 used a lower total dose than G2 (p=0.003). CONCLUSIONS: The concentration of 5% EO performed better than 1.25% and 2.5% for sclerotherapy of OVAs measuring up to 20 mm. This preliminary result should be the preferred concentration of EO to provide an effective and safe treatment of OVAs.


Assuntos
Soluções Esclerosantes/uso terapêutico , Escleroterapia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Ácidos Oleicos , Estudos Retrospectivos , Resultado do Tratamento
2.
Int J Oral Maxillofac Surg ; 48(5): 635-643, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-30459066

RESUMO

The aim of this study was to describe 40 cases of acquired oral syphilis (AOS) and to discuss the distribution of demographic characteristics, clinical features, and differential diagnosis of the disease. A retrospective study was conducted covering a 17-year period at a single institution in southern Brazil. Moreover, a literature review was performed through a search of the PubMed database for articles on AOS published between 1955 and March 2018. Data were analyzed descriptively. The predominant group within the case series was male patients in their twenties. The vast majority of cases (92.5%) were in the secondary stage of the disease. The lips were the most commonly affected site, with greyish-white mucous patches and reddish ulcers. In the literature review, the largest number of reported cases came from North America. Male patients in the third and fourth decades of life were most affected. AOS occurred more commonly as mucous patches and ulcers on the tongue and palate. Similarities regarding the distribution by sex, age, and anatomical location were found in the present study when compared to cases reported elsewhere. Clinicians, oral pathologists, and maxillofacial surgeons should familiarize themselves with the variable spectrum of signs and symptoms of AOS in their clinical practice to improve diagnosis and management.


Assuntos
Doenças da Boca , Sífilis , Doenças da Língua , Brasil , Humanos , Masculino , Estudos Retrospectivos
3.
Int J Oral Maxillofac Surg ; 47(7): 900-907, 2018 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-29329829

RESUMO

The aim of this study was to evaluate the effectiveness and safety of 5% ethanolamine oleate (EO) foam in the treatment of low-flow venous malformations in the head and neck region. Seventeen consecutive patients (six male, 11 female) and 34 low-flow venous malformations were enrolled. The vascular anomalies ranged between 20mm and 80mm in size. The typical clinical indication was a swelling (88.2%) with a purple colour (85.3%); the most frequent location was the tongue (23.5%). Ethanolamine oleate foam was produced via the Tessari method and applied at 10mg per 1cm to the vascular anomalies. This process resulted in the highest clinical healing score in 64.7% of cases, and half of the patients reported a high level of satisfaction (score >9). In the majority of cases (88.2%), the patients reported that the pain immediately postoperative was mild or moderate. There were direct relationships between vascular anomaly size and the volume of EO applied, the number of sessions, and healing (P<0.05). No recurrence was observed during 6 months of follow-up. This case series showed the effectiveness and safety of 5% EO foam for the treatment of venous malformations in the head and neck region.


Assuntos
Malformações Arteriovenosas/terapia , Cabeça/irrigação sanguínea , Pescoço/irrigação sanguínea , Ácidos Oleicos/uso terapêutico , Soluções Esclerosantes/uso terapêutico , Escleroterapia/métodos , Adolescente , Adulto , Idoso , Criança , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Resultado do Tratamento
4.
Arch Osteoporos ; 12(1): 26, 2017 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-28265896

RESUMO

The aim of this study is to correlate radiometric indices from cone beam computed tomography (CBCT) images and bone mineral density (BMD) in postmenopausal women. Quantitative CBCT indices can be used to screen for women with low BMD. PURPOSE: Osteoporosis is a disease characterized by the deterioration of bone tissue and the consequent decrease in BMD and increase in bone fragility. Several studies have been performed to assess radiometric indices in panoramic images as low-BMD predictors. The aim of this study is to correlate radiometric indices from CBCT images and BMD in postmenopausal women. METHODS: Sixty postmenopausal women with indications for dental implants and CBCT evaluation were selected. Dual-energy X-ray absorptiometry (DXA) was performed, and the patients were divided into normal, osteopenia, and osteoporosis groups, according to the World Health Organization (WHO) criteria. Cross-sectional images were used to evaluate the computed tomography mandibular index (CTMI), the computed tomography index (inferior) (CTI (I)) and computed tomography index (superior) (CTI (S)). Student's t test was used to compare the differences between the indices of the groups' intraclass correlation coefficient (ICC). RESULTS: Statistical analysis showed a high degree of interobserver and intraobserver agreement for all measurements (ICC > 0.80). The mean values of CTMI, CTI (S), and CTI (I) were lower in the osteoporosis group than in osteopenia and normal patients (p < 0.05). In comparing normal patients and women with osteopenia, there was no statistically significant difference in the mean value of CTI (I) (p = 0.075). CONCLUSIONS: Quantitative CBCT indices may help dentists to screen for women with low spinal and femoral bone mineral density so that they can refer postmenopausal women for bone densitometry.


Assuntos
Absorciometria de Fóton/métodos , Densidade Óssea , Tomografia Computadorizada de Feixe Cônico/métodos , Osteoporose Pós-Menopausa/diagnóstico por imagem , Idoso , Doenças Ósseas Metabólicas/diagnóstico por imagem , Estudos de Casos e Controles , Feminino , Humanos , Mandíbula/diagnóstico por imagem , Pessoa de Meia-Idade , Pós-Menopausa
5.
Oral Dis ; 23(4): 471-476, 2017 May.
Artigo em Inglês | MEDLINE | ID: mdl-28028908

RESUMO

BACKGROUND: The amalgam-associated oral lichenoid lesion (AAOLL) shows clinical and histopathological features similar to oral lichen planus (OLP). Molecular researches to improve knowledge of pathogenesis and clinical behavior of AAOLL are still scarce. OBJECTIVE: We investigated for the first time the use of loss of heterozygosity (LOH) as a molecular approach for genetic characterization of AAOLL in comparison with OLP and evaluated the cell proliferation index. MATERIALS AND METHODS: The sample comprised nine AAOLLs, 10 OLPs, and eight NOMs matched by patients' gender and age. LOH was assessed using polymorphic microsatellite markers at chromosomes 9p (D9S157, D9S162, D9S171), 11q (D11S1369), and 17p (TP53, AFM238WF2). Cell proliferation was assessed by immunohistochemical expression of Ki-67 (MIB-1). The association between LOH and Ki-67 was investigated. RESULTS: Loss of heterozygosity occurred in 5/9 AAOLLs and in 2/10 OLPs in at least one marker each, while NOM showed no LOH. Cell proliferation index in AAOLL ranged from 2 to 23%. There was no association between cell proliferation and LOH, independent of the marker. CONCLUSION: Our study shows that the profile of molecular changes in AAOLL and OLP, evaluated by LOH and Ki-67 expression, is similar. Additional studies including larger samples should be performed to confirm or to refute our findings.


Assuntos
Amálgama Dentário/efeitos adversos , Erupções Liquenoides/etiologia , Perda de Heterozigosidade , Doenças da Boca/etiologia , Mucosa Bucal/fisiopatologia , Adulto , Idoso , Estudos de Casos e Controles , Proliferação de Células , Feminino , Humanos , Imuno-Histoquímica , Antígeno Ki-67/metabolismo , Líquen Plano Bucal/genética , Líquen Plano Bucal/fisiopatologia , Erupções Liquenoides/genética , Erupções Liquenoides/fisiopatologia , Masculino , Repetições de Microssatélites , Pessoa de Meia-Idade , Doenças da Boca/genética , Doenças da Boca/fisiopatologia , Polimorfismo Genético
6.
Int J Oral Maxillofac Surg ; 44(11): 1383-9, 2015 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-26194769

RESUMO

Fibrous hyperplasia is treated by surgical incision using a scalpel, together with removal of the source of chronic trauma. However, scalpel techniques do not provide the haemostasis that is necessary when dealing with highly vascular tissues. Diode laser surgery can be used in the management of oral tissues due to its high absorption by water and haemoglobin, and has provided good results in both periodontal surgery and oral lesions. The aim of the present study was to compare the effects of diode laser surgery to those of the conventional technique in patients with fibrous hyperplasia. A randomized clinical trial was performed in which surgical and postoperative evaluations were analyzed. On comparison of the laser-treated (study group) patients to those treated with a scalpel (control group), significant differences were observed in the duration of surgery and the use of analgesic medications. Over a 3-week period, clinical healing of the postoperative wound was significantly faster in the control group as compared to the study group. In conclusion, diode laser surgery proved to be more effective and less invasive when compared to scalpel surgery in the management of fibrous hyperplasia. However, wound healing proved to be faster when using scalpel surgery.


Assuntos
Lasers Semicondutores/uso terapêutico , Mucosa Bucal/lesões , Mucosa Bucal/cirurgia , Procedimentos Cirúrgicos Bucais , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Criança , Dentaduras/efeitos adversos , Feminino , Fibrose/etiologia , Fibrose/cirurgia , Humanos , Hiperplasia/etiologia , Hiperplasia/cirurgia , Masculino , Pessoa de Meia-Idade , Resultado do Tratamento
7.
Int J Oral Maxillofac Surg ; 41(12): 1527-31, 2012 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-22613811

RESUMO

This study evaluated the performance of an upgrading of the micro-marsupialisation technique for the management of mucus extravasation or retention phenomena. This study presents a prospective case series of management of ranulas and mucoceles, with a follow-up ranging from 6 to 18 months. Data included the age and gender of patients, as well as the type, size, and site of lesions, and number of punctures. The treatment performance was evaluated according to: postoperative pain, oedema, secondary infection, clinical healing, retreatment, and recurrence of the lesions. All patients showed clinical healing of the lesions within 30 days after the micro-marsupialisation technique. None of patients presented a recurrence or required retreatment, there was no oedema or infection. No pain, or mild pain was reported by the majority of patients (58.81%). Micro-marsupialisation proved to be a simple, low cost, relatively non-invasive, painless, effective, and low recurrence technique to treat mucus extravasation or retention phenomena. Micro-marsupialisation can be recommended primarily to treat oral ranulas and selected mucoceles.


Assuntos
Mucocele/cirurgia , Muco , Procedimentos Cirúrgicos Bucais/métodos , Rânula/cirurgia , Humanos , Estudos Prospectivos
8.
Minerva Stomatol ; 57(9): 453-7, 2008 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-18923380

RESUMO

Mucoepidermoid carcinomas (MECs) are the most common malignancy of the salivary glands demonstrating a wide range of histologic variants and behavior. However, the sclerosing mucoepidermoid carcinoma (SMEC), a morphologic variant of this tumor is extremely rare and has been described almost exclusively in the major glands. The prominent sclerosis observed may obscure its typical morphological feature resulting in a diagnostic challenge. We describe herein a case of SMEC in a 43-year-old-woman, occurring in the minor salivary glands of palate. To our knowledge only 13 cases have been reported until this moment, being only 2 in minor salivary glands. We also performed the immunohistochemical evaluation of c-erbB-2 and Ki-67, searching for an association with the histopathological findings and behavior.


Assuntos
Carcinoma Mucoepidermoide/patologia , Neoplasias das Glândulas Salivares/patologia , Glândulas Salivares Menores , Adulto , Feminino , Humanos , Imuno-Histoquímica
9.
Oral Dis ; 14(6): 510-3, 2008 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-18826382

RESUMO

AIM: To investigate the immunoexpression and diagnostic applicability of human erythrocyte-type glucose transporter protein (GLUT-1) in oral peripheral nerve sheath tumors. MATERIAL AND METHODS: Specimens diagnosed as oral peripheral nerve sheath tumors archived in the Oral Pathology Service of Universidade Federal de Minas Gerais from 1966 to 2006 were evaluated. Thirty-four lesions were included: 15 traumatic neuromas, 11 neurofibromas, four neurilemmomas, and four malignant peripheral nerve sheath tumors (MPNST). One case of neurofibroma was associated with neurofibromatosis type I. Immunohistochemistry for S-100 and GLUT-1 was performed. S-100 was immunopositive in all lesions. RESULTS: Benign lesions were immunopositive for GLUT-1 except in two (18.2%) cases of neurofibromas. In the traumatic neuroma, the perineuriums were immunopositive for GLUT-1. In the neurofibroma, the immunoreactivity was heterogeneous. Immunopositivity was observed at levels of 54.5% in the periphery of the lesion, 9.1% in the center, and 18.2% in both. The neurilemmoma demonstrated immunopositivity in the capsule. One case (25%) of MPNST presented GLUT-1 positive stain in occasional cells distributed homogeneously in all the tumor area. CONCLUSION: GLUT-1 is a useful marker for perineurial cells and should be included in the oral peripheral nerve sheath tumors immunophenotyping thus aiding in the correct diagnosis of these lesions.


Assuntos
Transportador de Glucose Tipo 1/análise , Neoplasias Bucais/patologia , Neoplasias da Bainha Neural/patologia , Biomarcadores Tumorais/análise , Núcleo Celular/patologia , Tecido Conjuntivo/patologia , Diagnóstico Diferencial , Humanos , Imuno-Histoquímica , Imunofenotipagem , Fibras Nervosas/patologia , Neurilemoma/patologia , Neurofibroma/patologia , Neurofibromatose 1/patologia , Neuroma/patologia , Proteínas S100/análise
10.
Minerva Stomatol ; 57(1-2): 59-63, 2008.
Artigo em Inglês | MEDLINE | ID: mdl-18427372

RESUMO

Inflammatory myofibroblastic tumor is a rare lesion composed of myofibroblastic spindle cells accompanied by inflammatory infiltrate. The objective of this paper is to report an uncommon case of inflammatory myofibroblastic tumor located in the alveolar mucosa of the mandible. A 33-year-old male presented an asymptomatic tumoral lesion, firm, pedunculated, pink-colored, covered by smooth mucosa, with focal ulceration, measuring 30x20x20 mm, located in the left posterior alveolar mucosa. Clinical diagnosis was soft tissue tumor. An excisional biopsy was made. Microscopic examination showed compact fascicular spindle cells proliferation with a diffuse inflammatory infiltrate of plasma cells, lymphocytes, and eosinophils. Large ganglion-like cells were observed. The lesional cells were immunopos-itive to vimentin, a-smooth muscle actin, muscle specific actin, and CD68. Negative immunostain was observed to S-100, Bcl-2, Ki-67, desmin, CD34, and cytokeratin. A diagnosis of inflammatory myofibroblastic tumor was performed. After 28 months of follow-up there was no recurrence. Although no evidence of oral inflammatory myofibroblastic tumor recurrence or malignant transformation has been reported, it has been observed that in inflammatory myofibroblastic tumor of other regions a prolonged follow-up is necessary after surgical excision.


Assuntos
Mucosa Bucal , Neoplasias Bucais/patologia , Neoplasias de Tecido Muscular/patologia , Adulto , Humanos , Masculino , Mandíbula
11.
Oral Dis ; 13(6): 564-9, 2007 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-17944673

RESUMO

OBJECTIVES: Plasmablastic lymphoma (PBL) of the oral cavity is an aggressive neoplasm derived from B cell, considered to be the second more common among human immunodeficiency virus (HIV)-associated malignancies. As Epstein-Barr virus (EBV) infection has been associated with this neoplasm, the aim of the present study was to assess the presence of EBV in 11 cases of oral HIV-related PBL and investigate the controversial issue of the presence of Human herpesvirus-8 (HHV-8) in these tumors. METHODS: DNA was extracted from nine cases of HIV-associated oral lymphomas, diagnosed as PBL, and genomic material was amplified by polymerase chain reaction to verify the presence of EBV. In situ hybridization (ISH) for EBV was performed in five cases. Immunohistochemical analysis was conducted to confirm previous diagnosis and verify HHV-8 infection. RESULTS: The 11 cases had diagnosis confirmed by immunohistochemical analysis. Only nine cases presented an adequate amount of DNA for analysis, and EBV was detected in seven of them. The five cases tested for EBV viral infection by ISH showed positive signals. All 11 cases were negative for HHV-8. CONCLUSION: The presence of EBV in all cases studied favors a direct role of this virus in the development of HIV-related PBL, and this finding could be considered when dealing with HIV patients.


Assuntos
DNA Viral/análise , Herpesvirus Humano 4/isolamento & purificação , Linfoma Relacionado a AIDS/virologia , Neoplasias Bucais/virologia , Adulto , Infecções por Vírus Epstein-Barr/virologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade
12.
Minerva Stomatol ; 56(3): 115-9, 2007 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-17327815

RESUMO

AIM: The purpose of this study is to present data on a series of peripheral odontogenic fibroma, WHO (World Health Organization)-type (POF), in Brazilians and to compare the results with previously reported studies. METHODS: The study sample was made from the number of POF cases and its synonymies diagnosed from 1950 to 2004 at the Oral Pathology Service of the Federal University of Minas Gerais. The cases were reviewed in hematoxylin-eosin stain and the histological features were evaluated in accordance with the classification WHO. Patient's data about gender, age and race and the lesion's clinical data were obtained from the biopsy request forms, after the definite diagnosis of POF. RESULTS: Seventeen diagnoses of POF were found. Data showed that POF has a higher prevalence in females (88.2%), occurring in the second and fourth decades of life (29.4% each), and in Caucasians (64.7%). The most common location was the posterior region of the mandible (41.1%). It was an asymptomatic lesion (23.5%) with an average size of 1.1 to 2.0 cm (35.2%). The histological findings were: 1) fibroblastic tissue high cellularity (58.8%); 2) scarce odontogenic epithelium (64.7%); 3) inflammation (94.1%) and 4) absence of calcification (58.8%). CONCLUSIONS: Clinical and histological data of POF in Brazilians showed important characteristcs for its diagnosis. This epidemiological data will generate a substantial contribution to the clinical, histological diagnosis and behavior of this lesion.


Assuntos
Fibroma/patologia , Neoplasias Maxilomandibulares/patologia , Tumores Odontogênicos/patologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Brasil , Criança , Feminino , Fibroma/classificação , Humanos , Neoplasias Maxilomandibulares/classificação , Masculino , Pessoa de Meia-Idade , Tumores Odontogênicos/classificação , Estudos Retrospectivos
13.
Oral Dis ; 13(1): 51-5, 2007 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-17241430

RESUMO

AIM: To investigate the accuracy of histological diagnosis of oral hemangioma, oral vascular malformation and oral pyogenic granuloma according to immunohistochemical evaluation of the human erythrocyte-type glucose transporter protein (GLUT-1), and to observe the immunoexpression of this protein in oral varix. MATERIALS AND METHODS: Immunohistochemistry for GLUT-1 was performed in 93 histologically diagnosed cases of oral benign vascular lesions: 17 vascular malformations, 19 hemangiomas, nine varix, and 48 pyogenic granulomas. Descriptive analyses were performed. RESULTS: None of the cases of the oral benign vascular lesions evaluated were immunopositive to GLUT-1. The 19 cases histologically diagnosed as oral hemangioma that showed negative staining to GLUT-1 were reclassified as oral pyogenic granuloma or oral vascular malformations. The histological evaluation itself is not enough to obtain the correct diagnosis of oral HEM as none of the sample cases were true hemangioma. All sample cases with initial vascular malformation or pyogenic granulomas classification were negative to GLUT-1, demonstrating the accuracy of histological diagnosis of these lesions itself. Oral varix showed negative staining to GLUT-1 in blood vessels. CONCLUSIONS: GLUT-1 is an useful, effective and important auxiliary marker for the diagnosis of oral benign vascular lesions. CLINICAL RELEVANCE: This study showed that histological diagnosis alone is not sufficient to correct diagnoses of oral hemangioma. Moreover, immunohistochemistry to GLUT-1 is a useful and easy diagnostic method that may be used to avoid such misdiagnosis. Accurate diagnosis of these oral lesions has an important clinical relevance allowing: (1) correct management, (2) adequate communication among the multidisciplinary team (dentist, dermatologist, pediatrist, radiologist, pathologist, and surgeon), (3) understanding of the biological behavior of the lesions, and (4) facilitate the development of new therapeutic modalities. Thus, supporting the use of this marker in medical and dentistry communities is warranted.


Assuntos
Transportador de Glucose Tipo 1/análise , Doenças da Boca/diagnóstico , Neoplasias Bucais/diagnóstico , Biomarcadores/análise , Biomarcadores Tumorais/análise , Vasos Sanguíneos/anormalidades , Vasos Sanguíneos/patologia , Diagnóstico Diferencial , Granuloma Piogênico/diagnóstico , Granuloma Piogênico/patologia , Hemangioma/diagnóstico , Hemangioma/patologia , Humanos , Imuno-Histoquímica , Boca/irrigação sanguínea , Doenças da Boca/patologia , Neoplasias Bucais/patologia , Varizes/diagnóstico , Varizes/patologia
14.
Braz. j. phys. ther. (Impr.) ; 10(4): 387-392, out.-dez. 2006. graf
Artigo em Português | LILACS-Express | LILACS | ID: lil-448249

RESUMO

OBJETIVO: Verificar a influência dos exercícios perineais e dos cones vaginais, em associação aos exercícios posturais corretivos para a normalização estática da pelve, no tratamento da incontinência urinária feminina. MÉTODOS: Foram avaliadas 12 mulheres apresentando queixa de incontinência urinária, com idade média de 52,3 ± 9,7, submetidas a 10 sessões fisioterapêuticas, duas vezes na semana, divididas em dois grupos: Grupo A: n = 6, utilizando exercícios perineais e Grupo B: n = 6, utilizando cones vaginais. Ambos os grupos realizaram exercícios posturais para correção estática da pelve, conforme alterações de cada participante. Foram coletados os seguintes dados, antes e após intervenção: grau de contração muscular do períneo, pela Avaliação Funcional do Assoalho Pélvico (AFA); perda quantitativa de urina, mensurada pelo teste da almofada (Pad-Test), e sensações de umidade e desconforto, verificadas pelas Escalas Visuais Análogas (EVA). Os dados posturais foram coletados através do exame estático da pelve, exame de flexibilidade das cadeias musculares e avaliação postural. RESULTADOS: Na comparação dos dados pré e pós-intervenção, foi observado, para ambos os grupos, diminuição estatisticamente significativa da perda urinária (p < 0,05), ganho de contração muscular do assoalho pélvico e diminuição significativa da sensação de umidade. O grau de sensação de desconforto, pós-intervenção, foi significativamente menor para o grupo de exercícios perineais. O equilíbrio estático pélvico foi corrigido na maioria das voluntárias e houve ganho de flexibilidade das cadeias musculares. CONCLUSÃO: A correção estática da pelve, através dos exercícios posturais, constitui uma modalidade efetiva de intervenção na IU feminina, quando associada à reeducação perineal.


OBJECTIVE: To investigate the influence of perineal exercises and vaginal cones in association with corrective postural exercises for static normalization of the pelvis, on female urinary incontinence treatment. METHOD: Twelve women with urinary incontinence complaints (mean age: 52.3 ± 9.7) were assessed via 10 physical therapy sessions, twice a week. They were divided into two groups: Group A (n = 6) underwent perineal exercises, while Group B (n = 6) used vaginal cones. Both groups performed postural exercises for static correction of the pelvis, in accordance with each patient's abnormalities. The following data were collected before and after the intervention: degree of perineal muscle contraction, via functional evaluation of the pelvic floor (FEPF); quantitative urinary loss, using the pad test; and sensations of dampness and discomfort, via a visual analog scale (VAS). Postural data were collected using the static pelvic test, muscle chain flexibility test and postural evaluation. RESULTS: Comparing the data before and after the intervention, there were statistically significant decreases in urinary loss (p < 0.05) for both groups. There were gains in pelvic floor muscle contraction and significant decreases in the sensation of dampness. The degree of discomfort following the intervention was significantly lower for the group that did perineal exercises. The pelvic static balance was corrected in most of the volunteers and there were gains in muscle chain flexibility. CONCLUSIONS: Static correction of the pelvis by means of postural exercises is an efficient method for female urinary incontinence treatment when associated with perineal muscle training.

15.
Int J Paediatr Dent ; 16(5): 376-9, 2006 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-16879337

RESUMO

AIM: The present paper reports a case of peripheral odontogenic fibroma (POF) (WHO type) in a newborn. The differential diagnosis and treatment were discussed. BACKGROUND: POF is well described in the literature, but this is the first report in a newborn. PATIENT: A 4-month-old female newborn was referred to our department because of an exophytic, sessile, firm, and well-delimited lesion on the right upper alveolar ridge. The covering mucosa was apparently normal. The lesion measuring 10 x 3 mm was present since birth. The clinical diagnosis of congenital granular cell tumour (congenital epulis) or dental lamina cyst of the newborn was made. A conservative excisional biopsy was performed under local anaesthesia, and the specimen was submitted to histopathological examination. RESULTS: The microscopic examination revealed a pattern of POF (WHO type). Normal primary incisors teeth eruption, and no signs of recurrence were noted on 16 months follow-up. CONCLUSION: Despite the rarity of POF in a newborn, this lesion should be included as a possible diagnosis to focal gingival growth.


Assuntos
Processo Alveolar/patologia , Fibroma/patologia , Neoplasias Maxilares/patologia , Tumores Odontogênicos/patologia , Processo Alveolar/cirurgia , Diagnóstico Diferencial , Feminino , Fibroma/cirurgia , Humanos , Lactente , Neoplasias Maxilares/cirurgia , Tumores Odontogênicos/cirurgia
16.
Braz J Med Biol Res ; 39(5): 621-7, 2006 May.
Artigo em Inglês | MEDLINE | ID: mdl-16648900

RESUMO

The aim of the present investigation was to study the effect of acute swimming training with an anaerobic component on matrix metallopeptidase (MMP) activity and myosin heavy chain gene expression in the rat myocardium. Animals (male Wistar rats, weighing approximately 180 g) were trained for 6 h/day in 3 sessions of 2 h each for 1 to 5 consecutive days (N = 5 rats per group). Rats swam in basins 47 cm in diameter and 60 cm deep filled with water at 33 to 35 degrees C. After the training period a significant increase (P < 0.05) was observed in the heart weight normalized to body weight by about 22 and 35% in the groups that trained for 96 and 120 h, respectively. Blood lactate levels were significantly increased (P < 0.05) in all groups after all training sessions, confirming an anaerobic component. However, lactate levels decreased (P < 0.05) with days of training, suggesting that the animals became adapted to this protocol. Myosin heavy chain-beta gene expression, analyzed by real time PCR and normalized with GAPDH gene expression, showed a significant two-fold increase (P < 0.01) after 5 days of training. Zymography analysis of myocardium extracts indicated a single approximately 60-kDa activity band that was significantly increased (P < 0.05) after 72, 96, and 120 h, indicating an increased expression of MMP-2 and suggesting precocious remodeling. Furthermore, the presence of MMP-2 was confirmed by Western blot analysis, but not the presence of MMP-1 and MMP-3. Taken together, our results indicate that in these training conditions, the rat heart undergoes early biochemical and functional changes required for the adaptation to the new physiological condition by tissue remodeling.


Assuntos
Metaloproteinases da Matriz/metabolismo , Miocárdio/metabolismo , Cadeias Pesadas de Miosina/metabolismo , Natação/fisiologia , Remodelação Ventricular/fisiologia , Animais , Western Blotting , Peso Corporal , Regulação da Expressão Gênica , Ácido Láctico/sangue , Masculino , Metaloproteinases da Matriz/genética , Miocárdio/enzimologia , Cadeias Pesadas de Miosina/genética , Tamanho do Órgão , Condicionamento Físico Animal , Reação em Cadeia da Polimerase , RNA Mensageiro/análise , Ratos , Ratos Wistar , Fatores de Tempo
17.
Braz. j. med. biol. res ; 39(5): 621-627, May 2006. tab, graf
Artigo em Inglês | LILACS | ID: lil-425792

RESUMO

The aim of the present investigation was to study the effect of acute swimming training with an anaerobic component on matrix metallopeptidase (MMP) activity and myosin heavy chain gene expression in the rat myocardium. Animals (male Wistar rats, weighing approximately 180 g) were trained for 6 h/day in 3 sessions of 2 h each for 1 to 5 consecutive days (N = 5 rats per group). Rats swam in basins 47 cm in diameter and 60 cm deep filled with water at 33 to 35°C. After the training period a significant increase (P < 0.05) was observed in the heart weight normalized to body weight by about 22 and 35 percent in the groups that trained for 96 and 120 h, respectively. Blood lactate levels were significantly increased (P < 0.05) in all groups after all training sessions, confirming an anaerobic component. However, lactate levels decreased (P < 0.05) with days of training, suggesting that the animals became adapted to this protocol. Myosin heavy chain-ß gene expression, analyzed by real time PCR and normalized with GAPDH gene expression, showed a significant two-fold increase (P < 0.01) after 5 days of training. Zymography analysis of myocardium extracts indicated a single ~60-kDa activity band that was significantly increased (P < 0.05) after 72, 96, and 120 h, indicating an increased expression of MMP-2 and suggesting precocious remodeling. Furthermore, the presence of MMP-2 was confirmed by Western blot analysis, but not the presence of MMP-1 and MMP-3. Taken together, our results indicate that in these training conditions, the rat heart undergoes early biochemical and functional changes required for the adaptation to the new physiological condition by tissue remodeling.


Assuntos
Animais , Masculino , Ratos , Metaloproteinases da Matriz/metabolismo , Miocárdio/metabolismo , Cadeias Pesadas de Miosina/metabolismo , Natação/fisiologia , Remodelação Ventricular/fisiologia , Western Blotting , Peso Corporal , Regulação da Expressão Gênica , Ácido Láctico/sangue , Metaloproteinases da Matriz/genética , Miocárdio/enzimologia , Cadeias Pesadas de Miosina/genética , Tamanho do Órgão , Condicionamento Físico Animal , Reação em Cadeia da Polimerase , Ratos Wistar , RNA Mensageiro/análise , Fatores de Tempo
18.
Phytother Res ; 19(7): 652-4, 2005 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-16161031

RESUMO

The Brazilian commercial ethanol propolis extract, also formulated to ensure physical and chemical stability, was found to inhibit oral candidiasis in 12 denture-bearing patients with prosthesis stomatitis candidiasis association.


Assuntos
Antifúngicos/farmacologia , Candida albicans/efeitos dos fármacos , Candidíase Bucal/prevenção & controle , Fitoterapia , Própole/farmacologia , Adulto , Idoso , Animais , Antifúngicos/administração & dosagem , Antifúngicos/uso terapêutico , Abelhas , Brasil , Dentaduras , Feminino , Humanos , Masculino , Testes de Sensibilidade Microbiana , Pessoa de Meia-Idade , Própole/administração & dosagem , Própole/uso terapêutico , Estomatite/microbiologia
19.
Dentomaxillofac Radiol ; 34(4): 256-8, 2005 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-15961603

RESUMO

Two cases are presented of a nasolabial cyst (NC) on which a radiographic contrast medium was used in order to define the real extension of the lesion. Use of contrast is important for visualizing the definite extensions of NC primarily in cases when plain radiographs may not show any detectable changes and CT can not be used.


Assuntos
Meios de Contraste , Cavidade Nasal/diagnóstico por imagem , Cistos não Odontogênicos/diagnóstico por imagem , Doenças Nasais/diagnóstico por imagem , Adulto , Feminino , Seguimentos , Humanos , Pessoa de Meia-Idade , Intensificação de Imagem Radiográfica
20.
Int Endod J ; 38(7): 465-9, 2005 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-15946267

RESUMO

AIM: To investigate the occurrence of apoptotic cell death in the epithelium of radicular cysts and to compare its frequency in lesions presenting a distinct functional state. METHODOLOGY: Twenty radicular cysts were selected and arranged into two groups with 10 lesions in each group: atrophic (quiescent) and hyperplastic (active) epithelium. Morphologic investigations of apoptosis were conducted by means of optic microscopy in haematoxylin and eosin slides. Immunohistochemical techniques to detect the bcl-2 protein were carried out by streptavidin-biotin-peroxidase assay. In both instances, 30 sequential high-power microscopic fields were observed to determine apoptotic (AI) and bcl-2 immunostaining (bcl-2I) indexes. The presence of AI and bcl-2I within the two groups was compared using the t-test. Correlation between the AI and the bcl-2I was investigated using the Spearman test. RESULTS: Apoptosis was detected in the epithelium of all cysts. Higher AI levels were found in lesions with an atrophic (0.17 +/- 0.19) rather than a hyperplastic (0.10 +/- 0.10) epithelium. The same was found for the bcl-2I levels (0.06 +/- 0.03 vs. 0.04 +/- 0.01, respectively). However, these differences were not statistically significant. A positive and significant correlation was found between AI and bcl-2I. CONCLUSIONS: Apoptosis was always present in the epithelium of the lesions and was more frequent in lesions with atrophic (quiescent) epithelium.


Assuntos
Apoptose , Cisto Radicular/patologia , Células Epiteliais/patologia , Humanos , Imuno-Histoquímica , Proteínas Proto-Oncogênicas c-bcl-2/análise
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