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Artigo em Inglês | MEDLINE | ID: mdl-31940515


OBJECTIVE: Tactile brain-computer interface (BCI) systems can provide new communication and control options for patients with impairments of eye movements or vision. One of the most common modalities used in these BCIs is the P300 potential. Until now, tactile P300 BCIs have been successfully constructed by situating tactile stimuli at various parts of the human body. This study proposed a novel tactile P300 BCI paradigm for further expanding the tactile stimulation methods. METHODS: In our proposed paradigm, the spatial target vibrotactile stimuli were delivered to subject's left and right cheeks. To validate the feasibility of our proposed paradigm, a traditional tactile P300 BCI paradigm employing spatial target vibrotactile stimuli to subject's left and right wrists was used for comparison. RESULTS: The experimental results of nine healthy subjects demonstrated that the proposed paradigm could obtain significantly higher classification accuracy and information transfer rate than the traditional paradigm (both for p < 0.05). Furthermore, the subjective feedback showed that our proposed paradigm was more favored by the subjects compared to the traditional paradigm, and most subjects reported that the new paradigm helped them easily distinguish between targets and non-targets. CONCLUSION: The proposed tactile P300 BCI paradigm is feasible, and can bring about superior performance and use-evaluation. SIGNIFICANCE: The new paradigm might lead to many promising applications of such BCIs.

IEEE Trans Neural Syst Rehabil Eng ; 28(1): 3-12, 2020 01.
Artigo em Inglês | MEDLINE | ID: mdl-31794401


P300-based brain-computer interfaces (BCIs) provide an additional communication channel for individuals with communication disabilities. In general, P300-based BCIs need to be trained, offline, for a considerable period of time, which causes users to become fatigued. This reduces the efficiency and performance of the system. In order to shorten calibration time and improve system performance, we introduce the concept of a generic model set. We used ERP data from 116 participants to train the generic model set. The resulting set consists of ten models, which are trained by weighted linear discriminant analysis (WLDA). Twelve new participants were then invited to test the validity of the generic model set. The results demonstrated that all new participants matched the best generic model. The resulting mean classification accuracy equaled 80% after online training, an accuracy that was broadly equivalent to the typical training model method. Moreover, the calibration time was shortened by 70.7% of the calibration time of the typical model method. In other words, the best matching model method only took 81s to calibrate, while the typical model method took 276s. There were also significant differences in both accuracy and raw bit rate between the best and the worst matching model methods. We conclude that the strategy of combining the generic models with online training is easily accepted and achieves higher levels of user satisfaction (as measured by subjective reports). Thus, we provide a valuable new strategy for improving the performance of P300-based BCI.

Neural Netw ; 118: 262-270, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31326660


Multi-channel EEG data are usually necessary for spatial pattern identification in motor imagery (MI)-based brain computer interfaces (BCIs). To some extent, signals from some channels containing redundant information and noise may degrade BCI performance. We assume that the channels related to MI should contain common information when participants are executing the MI tasks. Based on this hypothesis, a correlation-based channel selection (CCS) method is proposed to select the channels that contained more correlated information in this study. The aim is to improve the classification performance of MI-based BCIs. Furthermore, a novel regularized common spatial pattern (RCSP) method is used to extract effective features. Finally, a support vector machine (SVM) classifier with the Radial Basis Function (RBF) kernel is trained to accurately identify the MI tasks. An experimental study is implemented on three public EEG datasets (BCI competition IV dataset 1, BCI competition III dataset IVa and BCI competition III dataset IIIa) to validate the effectiveness of the proposed methods. The results show that the CCS algorithm obtained superior classification accuracy (78% versus 56.4% for dataset1, 86.6% versus 76.5% for dataset 2 and 91.3% versus 85.1% for dataset 3) compared to the algorithm using all channels (AC), when CSP is used to extract the features. Furthermore, RCSP could further improve the classification accuracy (81.6% for dataset1, 87.4% for dataset2 and 91.9% for dataset 3), when CCS is used to select the channels.

Interfaces Cérebro-Computador , Eletroencefalografia/métodos , Máquina de Vetores de Suporte , Eletroencefalografia/normas , Humanos
Int J Mol Sci ; 18(11)2017 Nov 14.
Artigo em Inglês | MEDLINE | ID: mdl-29135934


With the avalanche of biological sequences in public databases, one of the most challenging problems in computational biology is to predict their biological functions and cellular attributes. Most of the existing prediction algorithms can only handle fixed-length numerical vectors. Therefore, it is important to be able to represent biological sequences with various lengths using fixed-length numerical vectors. Although several algorithms, as well as software implementations, have been developed to address this problem, these existing programs can only provide a fixed number of representation modes. Every time a new sequence representation mode is developed, a new program will be needed. In this paper, we propose the UltraPse as a universal software platform for this problem. The function of the UltraPse is not only to generate various existing sequence representation modes, but also to simplify all future programming works in developing novel representation modes. The extensibility of UltraPse is particularly enhanced. It allows the users to define their own representation mode, their own physicochemical properties, or even their own types of biological sequences. Moreover, UltraPse is also the fastest software of its kind. The source code package, as well as the executables for both Linux and Windows platforms, can be downloaded from the GitHub repository.

Biologia Computacional/métodos , Software , Análise por Conglomerados
J Environ Sci (China) ; 26(2): 307-14, 2014 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-25076522


We fabricated and characterized two hybrid adsorbents originated from hydrated ferric oxides (HFOs) using a polymeric anion exchanger D201 and calcite as host. The resultant adsorbents (denoted as HFO-201 and IOCCS) were employed for Sb(V) removal from water. Increasing solution pH from 3 to 9 apparently weakened Sb(V) removal by both composites, while increasing temperature from 293 to 313 K only improved Sb(V) uptake by IOCCS. HFO-201 exhibited much higher capacity for Sb(V) than for IOCCS in the absence of other anions in solution. Increasing ionic strength from 0.01 to 0.1 mol/L NaNO3 would result in a significant drop of the capacity of HFO-201 in the studied pH ranges; however, negligible effect was observed for IOCCS under similar conditions. Similarly, the competing chloride and sulfate pose more negative effect on Sb(V) adsorption by HFO-201 than by IOCCS, and the presence of silicate greatly decreased their adsorption simultaneously, while calcium ions were found to promote the adsorption of both adsorbents. XPS analysis further demonstrated that preferable Sb(V) adsorption by both hybrids was attributed to the inner sphere complexation of Sb(V) and HFO, and Ca(II) induced adsorption enhancement possibly resulted from the formation of HFO-Ca-Sb complexes. Column adsorption runs proved that Sb(V) in the synthetic water could be effectively removed from 30 microg/L to below 5 microg/L (the drinking water standard regulated by China), and the effective treatable volume of IOCCS was around 6 times as that of HFO-201, implying that HFO coatings onto calcite might be a more effective approach than immobilization inside D201.

Antimônio/isolamento & purificação , Compostos Férricos/química , Adsorção , Resinas de Troca de Ânions/química , Carbonato de Cálcio/química , Concentração de Íons de Hidrogênio , Concentração Osmolar