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Pediatr Hematol Oncol ; 27(3): 212-27, 2010 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-20367265


Interference with the molecular mechanisms that generate tumor supportive niches in the bone microenvironment is a rational approach to inhibit the growth of hematological malignancies. However, the advancement of knowledge in this area has been slowed down by the lack of in vitro models to facilitate the screening of potential candidate agents. The rare cases of acute lymphoblastic leukemia (ALL) in children presenting with extensive bone involvement may represent an exaggerated form of some aspects of the normal tumor-bone interactions. Thus, these cases can provide insight into processes that are otherwise challenging to uncover. The authors describe the case of a 6-year-old child who presented with severe osteopenia that resolved at the time of leukemic remission. Compared to control sera, serum taken at disease presentation contained increased levels of a group of osteolytic cytokines and was effective in activating preosteoclast cells in culture. Based on these findings, the authors describe an experimental model to identify agents that would interfere with leukemia mediated osteolytic process.

Doenças Ósseas Metabólicas/etiologia , Leucemia-Linfoma Linfoblástico de Células Precursoras/complicações , Pré-Escolar , Citocinas/sangue , Receptores ErbB/antagonistas & inibidores , Humanos , Masculino , Osteoclastos/fisiologia , Leucemia-Linfoma Linfoblástico de Células Precursoras/sangue , Leucemia-Linfoma Linfoblástico de Células Precursoras/tratamento farmacológico
Pediatr Dermatol ; 26(3): 338-41, 2009.
Artigo em Inglês | MEDLINE | ID: mdl-19706100


Discoid lupus erythematosus (DLE) is rare in childhood. We report the case of a 5-year-old girl who presented with erythematous scaly plaques, with scarring alopecia, involving approximately 40% of her scalp. Histopathology confirmed the diagnosis of DLE. Treatment with intravenous methylprednisolone, hydroxychloroquine, oral prednisone, topical corticosteroids, and sunscreen lead to reversal of scarring alopecia and re-growth of hair.

Corticosteroides/administração & dosagem , Anti-Inflamatórios/administração & dosagem , Hidroxicloroquina/administração & dosagem , Lúpus Eritematoso Discoide/tratamento farmacológico , Metilprednisolona/administração & dosagem , Dermatoses do Couro Cabeludo/tratamento farmacológico , Pré-Escolar , Cicatriz/patologia , Quimioterapia Combinada , Inibidores Enzimáticos , Feminino , Glucocorticoides/administração & dosagem , Cabelo/crescimento & desenvolvimento , Humanos , Lactente , Infusões Intravenosas , Lúpus Eritematoso Discoide/patologia , Lúpus Eritematoso Discoide/fisiopatologia , Prednisona/administração & dosagem , Dermatoses do Couro Cabeludo/patologia