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1.
Allergy ; 2022 Sep 29.
Artigo em Inglês | MEDLINE | ID: mdl-36176042

RESUMO

BACKGROUND: Little is known about the association between maternal use of heated tobacco products (HTPs) during pregnancy and the onset of allergy among offspring. This study aimed to determine whether maternal HTP smoking is associated with allergy in their offspring and to evaluate the potential dose-response association. METHODS: In this web-based, cross-sectional survey conducted in July and August 2021 in Japan, we investigated 5688 pairs of postpartum women and infants (<3 years). Clinical diagnoses of infant asthma, rhinitis, conjunctivitis, or atopic dermatitis were reported. Using multilevel Poisson regression, we estimated the prevalence ratios (PRs) and 95% confidence intervals (CIs) of allergy in infants with HTP smoking categories cross-classified by pregnancy periods, and adjusted for potential covariates including maternal cigarette smoking and partner's smoking status. Non-smokers served as the reference group. RESULTS: In total, 2.4% women smoked HTPs during pregnancy. Allergy occurred in 7.8% of the infants. The prevalence of allergy increased among the offspring of current HTP smokers during pregnancy at 15.2% (PR = 1.98, 95% CI 1.28-3.05); this association was the most pronounced during the first trimester but attenuated before pregnancy and postpartum. Dose-response associations were observed, for example a one-unit increase in daily maternal HTP use during pregnancy was associated with a 5% increase in allergy onset. Sub-group analyses excluding cigarette smokers during pregnancy and sensitivity analyses using the International Study of Asthma and Allergies in Childhood questionnaire showed a similar pattern. CONCLUSIONS: Maternal HTP smoking during pregnancy is associated with allergy in the offspring.

4.
Gan To Kagaku Ryoho ; 49(5): 589-592, 2022 May.
Artigo em Japonês | MEDLINE | ID: mdl-35578941

RESUMO

Oral uracil and tegafur plus Leucovorin(UFT/LV)therapy is one of the standard adjuvant chemotherapies for colorectal cancer, and is widely used without any serious adverse events. Herein, we describe a case of UFT/LV-induced acute liver failure in a 75-year-old woman who underwent laparoscopic sigmoidectomy for sigmoid colon cancer. She was diagnosed with advanced colon cancer and lymph node metastasis by postoperative histopathological analysis, and adjuvant chemotherapy was initiated. After 30 days of commencing the therapy, the patient visited our hospital with complaints of severe diarrhea and difficulty in food intake. The apparent cause of these symptoms was unclear on computed tomography(CT), and mild liver damage was revealed in blood test results. The hepatic disorder gradually progressed after the hospitalization, and the condition was diagnosed as acute hepatic insufficiency. Additionally, obvious atrophy of the liver parenchyma and significant ascites were confirmed on CT. Two months later, the platelet count decreased markedly, but fortunately, no bleeding occurred. There has been no recurrence since 2 years after the surgery without any additional adjuvant therapy.


Assuntos
Falência Hepática Aguda , Neoplasias do Colo Sigmoide , Idoso , Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos , Feminino , Humanos , Leucovorina/uso terapêutico , Falência Hepática Aguda/tratamento farmacológico , Neoplasias do Colo Sigmoide/tratamento farmacológico , Neoplasias do Colo Sigmoide/patologia , Neoplasias do Colo Sigmoide/cirurgia , Tegafur/efeitos adversos , Uracila/efeitos adversos
5.
ACS Omega ; 7(15): 12971-12977, 2022 Apr 19.
Artigo em Inglês | MEDLINE | ID: mdl-35474795

RESUMO

Nowadays, the increase in plastic waste is causing serious environmental problems. Catalytic cracking has been considered a promising candidate to solve these problems. Catalytic cracking has emerged as an attractive process that can produce valuable products from plastic wastes. Solid acid catalysts such as zeolites decompose the plastic waste at a lower temperature. The lower decomposition temperature may be desirable for practical use. Herein, we synthesized both Zr- and Al-incorporated Beta zeolite using amorphous ZrO2-SiO2. The optimized Zr content in the dry gel allowed the enhancement of Lewis acidity without a significant loss of Brønsted acidity. The enhancement of Lewis acidity was mainly due to Zr species incorporated into the zeolite framework. Thanks to the enhanced Lewis acidity without any significant loss of Brønsted acidity, higher polymer decomposition efficiency was achieved than a conventional Beta zeolite.

8.
Health Sci Rep ; 4(3): e379, 2021 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-34557596

RESUMO

BACKGROUND AND OBJECTIVES: Using a lung sound analysis, the prognosis of asthma was investigated in infants with risk factors for asthma development by a long-term observation. METHODS: A total of 268 infants were included (median age: 8 months old). The lung sound parameters (the ratio of the third and fourth area to the total area under the curve [A3/AT and B4/AT], and the ratio of power and frequency at 50% and 75% of the highest frequency [RPF50 and RPF75]) were evaluated at the first visit. At 3 years old, using a questionnaire, we examined the relationship between the lung sound parameters and risk factors of asthma development. RESULTS: Among the 268 infants, 175 infants were in good health and 93 had a history of acute respiratory infection (ARI) within 7 days at the first visit. Among the 3- to 12-month-old infants with an ARI, the A3/AT, B4/AT values in those with a history of asthma/asthmatic bronchitis, atopic dermatitis, and atopy were smaller than in the infants without such histories. Among the 13- to 24-month-old infants with an ARI, the A3/AT and B4/AT values in those with a wheezing history were larger than in the infants without such a history. CONCLUSIONS: The characteristics of the lung sounds in infants with risk factors for asthma development were demonstrated over long-term follow-up. Lung sound analyses may be useful for assessing the airway condition of infants.

12.
J Dermatol ; 48(4): 481-485, 2021 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-33523542

RESUMO

Vascular-type Ehlers-Danlos syndrome (vEDS) is an autosomal-dominant inherited disorder caused by a deficit in collagen III. It results from heterogeneous mutations in the α1 collagen III gene (COL3A1) and is associated with life-threatening complications, even in younger patients. However, the details of the pathogenesis underlying the COL3A1 mutation causing vEDS remain unclear. Here, we focus on anomalies in collagen fiber size and the endoplasmic reticulum (ER) stress response in patients with vEDS using electron microscopy (EM). We discovered that although the infants did not have vEDS, collagenous formations were similar to their samples in vEDS. Moreover, we examined the expression of activating transcription factor 6 (ATF6) as an ER stress marker and cartilage oligomeric matrix protein (COMP) as a binding partner protein for collagen fibrils in the dermis and COL3A1. The expression levels of ATF6 in the vEDS group were significantly higher than in infants and controls; COMP and COL3A1 levels were significantly lower. The fragile collagen fibrils in vEDS might form as a result of ER stress and that small, newly formed collagen fibrils may appear. This research revealed a novel prospect regarding an issue that has been unclear for a long time, which is the reason for the abnormal sizes of collagenous fibrils in vEDS.


Assuntos
Síndrome de Ehlers-Danlos , Colágeno Tipo III/genética , Síndrome de Ehlers-Danlos/diagnóstico , Síndrome de Ehlers-Danlos/genética , Estresse do Retículo Endoplasmático , Humanos , Microscopia Eletrônica , Mutação
14.
RSC Adv ; 11(12): 6667-6681, 2021 Feb 04.
Artigo em Inglês | MEDLINE | ID: mdl-35423191

RESUMO

Extensive effort has been focused on the advancement of an efficient catalyst for CO2 reforming of CH4 to achieve optimum catalytic activity together with cost-effectiveness and high resistance to catalyst deactivation. In this study, for the first time, a new catalytic support/catalyst system of bifunctional NiO/dolomite has been synthesized by a wet impregnation method using low-cost materials, and it shows unique performance in terms of amphoteric sites and self-reduction properties. The catalysts were loaded into a continuous micro-reactor equipped with an online GC-TCD system. The reaction was carried out with a gas mixture consisting of CH4 and CO2 in the ratio of 1 : 1 flowing 30 ml min-1 at 800 °C for 10 h. The physicochemical properties of the synthesized catalysts were determined by various methods including X-ray diffraction (XRD), N2 adsorption-desorption, H2 temperature-programmed reduction (H2-TPR), temperature-programmed desorption of CO2 (TPD-CO2), and temperature-programmed desorption of NH3 (TPD-NH3). The highest catalytic performance of the DRM reaction was shown by the 10% NiO/dolomite catalyst (CH4 & CO2 conversion, χCH4; χCO2 ∼ 98% and H2 selectivity, S H2 = 75%; H2/CO ∼ 1 : 1 respectively). Bifunctional properties of amphoteric sites on the catalyst and self-reduction behaviour of the NiO/dolomite catalyst improved dry reforming of the CH4 process by enhancing CH4 and CO2 conversion without involving a catalyst reduction step, and the catalyst was constantly active for more than 10 h.

16.
Exp Ther Med ; 19(2): 1091-1094, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-32010274

RESUMO

Childhood Guillain-Barré syndrome (GBS) occasionally leads to respiratory failure early after onset, requiring long-term ventilation management after tracheal intubation. However, patients requiring tracheostomy management are rare. In the present study, a case of a 12-year-old boy with GBS who required artificial respiration management due to rapid progression of respiratory muscle paralysis is reported. Intravenous immunoglobulin (IVIg) and pulse steroid therapy were provided; however, both were ineffective and tracheostomy was necessary 26 days after onset. A second course of IVIg and pulse steroid therapy was administered on day 34. With continued rehabilitation, the patient was able to walk long distances on day 74 and was subsequently discharged on day 89. In cases of severe GBS, when IVIg and pulse steroid therapy do not improve the respiratory muscle strength of the patient, early tracheostomy may improve the patient's quality of life during artificial respiration management.

18.
Int Arch Allergy Immunol ; 181(3): 183-190, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31822011

RESUMO

INTRODUCTION: Component-resolved diagnostics is used to diagnose food allergies. However, few reports have evaluated the severity of peach fruit allergy using peach allergen components, including Pru p 7. OBJECTIVE: This study aimed to predict peach fruit allergy severity based on the presence of specific IgE (sIgE) antibodies (Abs) to peach allergenic components. METHODS: Twenty-seven patients with peach fruit allergy were enrolled and classified into two groups: the local reaction (LR) group, including 12 patients with only oral or throat mucosal symptoms, and the systemic reaction (SR) group, including 15 patients, 10 of whom experienced anaphylaxis. Serum sIgE Abs against crude peach extract - Pru p 1, 2, 3, 4, and 7 - and tree pollen were measured. RESULTS: sIgE Ab titers of Pru p 1 and 4 and alder pollen in the LR group were significantly higher than those in the SR group. sIgE against Pru p 7 was significantly higher in the SR group than in the LR group. The frequencies of sIgE Abs against Pru p 1, 4, and 7 in the LR group were 91.7, 66.7, and 16.7%, respectively, while in the SR group these were 80, 20, and 60%. Sensitization to Pru p 2 and 3 was detected but limited in all patients. CONCLUSIONS: These findings suggest that sensitization to Pru p 1 and Pru p 4 is associated with local symptoms, and sensitization to Pru p 7 is associated with SR and anaphylaxis. To predict the severity of peach fruit allergy, it is useful to assess sIgE Ab reactions combining Pru p 1, 4, and 7.


Assuntos
Alérgenos/imunologia , Anafilaxia/diagnóstico , Antígenos de Plantas/imunologia , Hipersensibilidade Alimentar/diagnóstico , Proteínas de Plantas/imunologia , Adolescente , Adulto , Criança , Feminino , Frutas , Humanos , Imunoglobulina E/metabolismo , Japão , Masculino , Valor Preditivo dos Testes , Prognóstico , Prunus persica/imunologia , Adulto Jovem
19.
Pediatr Allergy Immunol Pulmonol ; 33(3): 147-154, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-35922027

RESUMO

Background: The parameters of lung sounds have been suggested as biomarkers of airway changes. Using a commercially available lung sound analyzer, we investigated the characteristics of the lung sounds in infants with acute respiratory infection (ARI). Methods: Infants with ARI who were 6 to 18 months of age were included in this study. The lung sound parameters, the ratio of the third area and fourth areas to the total area under the curve of the sound spectrum (A3/AT and B4/AT), and the ratio of power and frequency at 75% and 50% of the highest frequency of the power spectrum (RPF75 and RPF50) were evaluated. With an original Japanese questionnaire based on American Thoracic Society-Division of Lung Disease, the risk factors of asthma development in infants were examined. Results: One hundred ten infants with ARI and 248 infants in good health for comparison were included. All infants were completely analyzed, and then divided into 2 age groups for a stratification analysis (6-12 and 13-18 months). In the overall analysis, among infants with a history of wheezing, recurrent wheezing, allergy, and atopic dermatitis, the values of RPF50 of infants with ARI were significantly lower compared with those without ARI. In the 6- to 12-month-old group, the RPF50 values of atopy-positive infants with ARI were lower compared with those without ARI (P = 0.003). Conclusions: The lung sounds of the infants with asthma-developing risk factors were more affected by ARI than those of infants without risk factors. Analyzing the changes in the lung sounds induced by ARI may be useful for evaluating the characteristics of the airways in infants.

20.
Pediatr Int ; 61(10): 956-961, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31449704

RESUMO

BACKGROUND: To evaluate the frequency of wheezing in infants, the presence of wheezing was examined in normal infants using a breath sound analyzer, METHODS: A total of 443 infants (age range, 3-24 months) were included in the present study. The existence of audible wheezing and faint wheezing/inaudible wheezing-like noises (FW) was confirmed on chest auscultation and a sound spectrogram. The breath sound parameters of the sound spectrum, frequency limiting 99% of power spectrum (F99 ), roll-off from 600 to 1,200 Hz (slope) and spectrum curve indices, total area under the curve of dB data (A3 /AT and B4 /AT ), and ratio of power and frequency at 50% and 75% of the highest frequency of the power spectrum (RPF50 and RPF75 ) were calculated. Using an original Japanese questionnaire, we examined the characteristics of the airway condition of all infants. RESULTS: Finally, a total of 398 infants were analyzed in the present study, and 283 were in good health while 115 had acute respiratory infection (ARI) in the last 7 days. No infants had audible wheezing on auscultation. Three infants without ARI (1.1%) and 10 infants with ARI (8.7%) had FW. In the evaluation of breath sound parameters, there were no marked differences between the infants with and without FW. CONCLUSIONS: Using a breath sound analyzer, wheezing and FW were recognized in only a few infants in good health. Infants recognized to have audible wheezing in daily practice may be at risk of developing recurrent wheezing/asthma.


Assuntos
Sons Respiratórios/diagnóstico , Asma/diagnóstico , Asma/epidemiologia , Asma/etiologia , Estudos de Casos e Controles , Pré-Escolar , Feminino , Humanos , Lactente , Japão/epidemiologia , Masculino , Infecções Respiratórias/diagnóstico , Infecções Respiratórias/epidemiologia , Infecções Respiratórias/fisiopatologia , Medição de Risco
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