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1.
Eur J Pharmacol ; 863: 172701, 2019 Nov 15.
Artigo em Inglês | MEDLINE | ID: mdl-31568784

RESUMO

Myocardial ischemia/reperfusion (IR) injury is caused by the restoration of the coronary blood flow following an ischemic episode. Accumulating evidence suggests that galectin-3, a ß-galactoside-binding lectin, acts as a biomarker in heart disease. However, it remains unclear whether manipulating galectin-3 affects the susceptibility of the heart to IR injury. In this study, RNA sequencing (RNA-seq) analysis identified that Lgals3 (galecin-3) plays an indispensable role in IR-induced cardiac damage. Immunostaining and immunoblot assays confirmed that the expression of galectin-3 was markedly increased in myocardial IR injury both in vivo and in vitro. Echocardiographic analysis showed that cardiac dysfunction in experimental IR injury was significantly attenuated by galectin-3 inhibitors including pectin (1%, i.p.) from citrus and binding peptide G3-C12 (5.0 mg/kg, i.p.). Galectin-3 inhibitor-treated mice exhibited smaller infarct sizes and decreased tissue injury. Furthermore, TUNEL staining showed that galectin-3 inhibition suppressed IR-mediated cardiomyocyte apoptosis. Mitochondrial membrane potential (MMP) and mitochondrial permeability transition pore (mPTP) levels were well-preserved and IR-induced changes of mitochondrial cyto c, cytosol cyto c, caspase-9, caspase-3, Bcl-2 and Bax in the galectin-3 inhibitor-treated groups were observed. Our findings indicate that the pathological upregulation of galectin-3 contributes to IR-induced cardiac dysfunction and that galectin-3 inhibition ameliorates myocardial injury, highlighting its therapeutic potential.

2.
Drug Des Devel Ther ; 13: 2769-2776, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31496653

RESUMO

Objective: This study aimed to investigate the changes in inflammatory biomarkers between newly diagnosed type 2 diabetes (T2DM) patients under one-year acarbose treatments and those under metformin managements. Methods: Seventy patients with newly diagnosed T2DM and 32 volunteers with normal glucose tolerance (normal controls, NCs) were enrolled. Seventy patients with T2DM were randomly assigned to two subgroups and treated with acarbose (n=34) or metformin (n=36) for 1 year. Blood glucose, insulin, glycosylated hemoglobin (A1C), triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and inflammatory biomarker levels (interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), interleukin-1ß (IL-1ß), interleukin-2 (IL-2), and ferritin) were detected at 0, 6 and 12 months. Results: After adjusting for sex, the waist-to-hip ratio (WHR) and body mass index (BMI), higher fasting plasma glucose (FPG), standard meal test 1/2 hr and 2 hr glucose, TG, TC, LDL-C, IL-6, TNF-α, IL-2 and ferritin levels were observed in T2DM group than in NCs (P<0.05). After 6 months of treatment, TNF-α levels were significantly decreased in both subgroups, and IL-6 and ferritin levels were significantly decreased after 12 months (P<0.05). However, no significant differences in the IL-6, TNF-α and ferritin levels were observed between the two subgroups. Moreover, significantly higher IL-6 and TNF-α levels were detected in the T2DM group than in NCs after 12 months of treatment (P<0.05). Conclusion: Patients with newly diagnosed T2DM exhibited a marked chronic inflammatory state characterized by increased IL-6, TNF-α, IL-1ß, IL-2 and ferritin levels. After 1 year of treatment with acarbose or metformin, IL-6, TNF-α, IL-1ß and ferritin levels were significantly decreased compared with the baseline. The anti-inflammatory effects of acarbose and metformin were comparable and required a long-term treatment (1 year), but the characteristics were different. Further investigations are needed to determine whether this effect was independent of the hypoglycemic effects.

3.
Biomed Res Int ; 2019: 5897505, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31467900

RESUMO

Q192R and L55M polymorphism were considered to be associated with the development of multiple cancers. Nevertheless, the results of these researches were inconclusive and controversial. Therefore, we conducted a meta-analysis of all eligible case-control studies to assess the association between PON1 (Q192R and L55M) gene polymorphisms and risk of cancer. With the STATA 14.0 software, we evaluated the strength of the association by using the odds ratios (ORs) and 95% confidence intervals (CIs). A total of 43 case-control publications 19887 cases and 23842 controls were employed in our study. In all genetic models, a significant association between PON1-L55M polymorphisms and overall cancer risk was observed. Moreover, in the stratified analyses by cancer type, polymorphism of PON1-L55M played a risk factor in the occurrence of breast cancer, hematologic cancer, and prostate cancer. Similarly, an increased risk was observed in the Caucasian and Asian population as well as hospital-based group and population-based group. For PON1-Q192R polymorphisms, in the stratified analyses by cancer type, PON1-Q192R allele was associated with reduced cancer risks in breast cancer. Furthermore, for racial stratification, there was a reduced risk of cancer in recession model in Caucasian population. Similarly, in the stratification analysis of control source, the overall risk of cancer was reduced in the heterozygote comparison and dominant model in the population-based group. In conclusion, PON1-Q192R allele decreased the cancer risk especially breast cancer; there was an association between PON1-L55M allele and increased overall cancer risk. However, we need a larger sample size, well-designed in future and at protein levels to confirm these findings.

4.
BMJ Open ; 9(6): e027736, 2019 Jun 11.
Artigo em Inglês | MEDLINE | ID: mdl-31189679

RESUMO

OBJECTIVES: We aimed to gain a better understanding of patients' practice of hand hygiene (HH) and their knowledge and attitudes. DESIGN: A cross-sectional survey. SETTING: A 3500-bed university-affiliated medical hospital in China. PARTICIPANTS: Inpatients and their family members or caregivers. METHODS: An anonymous, self-reported questionnaire were used to collect data. RESULTS: A total of 376 questionnaires were issued, and 310 respondents completed it. Of the 310 respondents, 47.4% had received HH education, and 13.5% had a completing understanding of HH. A majority of patients believed that handwashing was important for disease recovery, and that it could prevent infection development. A total of 62.3% of patients washed their hands <5 times a day and 49.0% spent <1 min every time. With regards to the seven steps of handwashing, 96.45% of the respondents adhered to the first step (washing the palms), but only 20.6% adhered to the fifth step (thumbs) and 17.7% to the sixth step (fingertips). Most respondents washed their hands only when visibly dirty. Few patients washed their hands before drinking fluids, and before and after interacting with visitors. HH compliance was lower among intensive care unit patients than medical patients. CONCLUSIONS: In conclusion, this study demonstrated that patients had a positive attitude towards HH. However, their levels of knowledge and practice were unsatisfactory. A systematical education about patientHH is needed in future to correct this knowledge and behaviour.

5.
J Nanosci Nanotechnol ; 19(12): 7899-7905, 2019 Dec 01.
Artigo em Inglês | MEDLINE | ID: mdl-31196306

RESUMO

Using the embedded-atom method, the elastic moduli as a function of the size of Fe, Nb, Cu and RuAl nanoparticles were investigated. By decreasing particle size, a decrease in moduli was observed, and the softening of the modulus correlated with the inverse Hall-Petch relation. This softening mechanism of a nanomaterial might be attributable to easy movement of the internal/surface dislocations of a grain at a low shear modulus. The effect of size on the physical properties of the nanoparticles (>5.0 nm) was found to be smaller than those of the particles (<5.0 nm). It was concluded that nanograins larger than 5 nm have elastic moduli to be approximately equal to ones of their bulk counterpart.

6.
ACS Appl Mater Interfaces ; 11(16): 14960-14969, 2019 Apr 24.
Artigo em Inglês | MEDLINE | ID: mdl-30921512

RESUMO

Graphene oxide (GO) has become a promising 2D material in many areas, such as gas separation, seawater desalination, antibacterial materials, and so on because of its abundant oxygen-containing functional groups and excellent dispersibility in various solvents. The graphene oxide membrane (GOM), a laminar and channel-rich structure assembled by stacked GO nanosheets, served as a kind of precise and ultrafast separation material has attracted widespread attention in membrane separation field. To break the trade-off between ion permeability and ion selectivity of separation membrane based on GOM, GOM/conical nanopore system is obtained by spin-coating ultrathin GOM on PET conical nanopore, which possesses ion rectification property. Comparing to pure PET conical nanopore, the existence of GOM not only enhances the cation conductance but also makes the ion rectification ratio increase from 4.6 to 238.0 in KCl solution. Assisted by COMSOL simulation, it is proved that the GOM can absorb large amount of cations and act as cation source to improve the ion selectivity and rectification effect of GOM/conical nanopore system. Finally, the chemical stability of GOM/conical nanopore is also investigated and the corresponding results reveal that the GOM/conical nanopore system can perform the ion rectification behavior in a wider pH range than pure PET conical nanopore. The presented findings demonstrate the great potential applications of GOM/conical nanopore system in ionic logic circuits and sensor systems.

7.
Toxicol Appl Pharmacol ; 369: 60-72, 2019 Apr 15.
Artigo em Inglês | MEDLINE | ID: mdl-30831131

RESUMO

Hypoxic pulmonary vasoconstriction (HPV) can be modulated by Rho/Rho kinase signaling, which can alter HPV vascular function via regulating myosin light chain phosphorylation, in a manner generally believed to be Ca2+-independent. We hypothesized that the RhoA/ROCK signaling pathway also can regulate HPV vascular function via a Ca2+-dependent mechanism, signaling through the functional transient receptor potential canonical (TRPC) channels. In this study, male BALB/c mice were exposed to normoxic or 10% oxygen (hypoxic) conditions for six weeks, after which systolic pressure and right ventricular hypertrophy were assessed. Transient intracellular calcium was monitored using a fluorescence imaging system. Muscle tension was measured with a contractile force recording system, and protein expression was assessed by immunoblotting. We found that the expressions of RhoA and ROCK were increased in mouse pulmonary arteries (PAs) under conditions of chronic hypoxia. Inhibition of the RhoA/ROCK signaling pathway prevented the development of hypoxic pulmonary hypertension (HPH), as evidenced by significantly reduced PA remodeling and pulmonary vasoconstriction. Immunoblotting results revealed that inhibition of the RhoA/ROCK signaling pathway significantly decreased the expression of HIF-1α. Knockdown of HIF-1α down-regulated the expression and function of the TRPC1 and TRPC6 channels in PASMCs under conditions of hypoxia. Contraction of the PAs and a Ca2+ influx into PASMCs through either receptor- or store-operated Ca2+ channels were also increased after hypoxia. However, RhoA/ROCK inhibitors markedly attenuated these changes. These results indicate that inhibition of the RhoA/ROCK signaling pathway ameliorates HPH via HIF-1α-dependent functional TRPCs.

8.
Toxicol Appl Pharmacol ; 368: 26-36, 2019 04 01.
Artigo em Inglês | MEDLINE | ID: mdl-30776389

RESUMO

Cardiac dysfunction is a vital complication during endotoxemia (ETM). Accumulating evidence suggests that enhanced glycolytic metabolism promotes inflammatory and myocardial diseases. In this study, we performed deep mRNA sequencing analysis on the hearts of control and lipopolysaccharide (LPS)-challenged mice (40 mg/kg, i.p.) and identified that the glycolytic enzyme, 6-phosphofructo-2-kinase (PFK-2)/fructose-2,6-bisphosphatase 3 (PFKFB3) might play an indispensable role in ETM-induced cardiac damage. Quantitative real-time PCR validated the transcriptional upregulation of PFKFB3 in the myocardium of LPS-challenged mice and immunoblotting and immunostaining assays confirmed that LPS stimulation markedly increased the expression of PFKFB3 at the protein level both in vivo and in vitro. The potent antagonist 3-(3pyridinyl)-1-(4-pyridinyl)-2-propen-1-one (3PO) was used to block PFKFB3 activity in vivo (50 mg/kg, i.p.) and in vitro (10 µM). Echocardiographic analysis and TUNEL staining showed that 3PO significantly alleviated LPS-induced cardiac dysfunction and apoptotic injury in vivo. 3PO also suppressed the LPS-induced secretion of tumor necrosis factor-α, interleukin (IL)-1ß, IL-6 and lactate in the serum, in addition to lactate in the myocardium. PFKFB3 inhibition also diminished the nuclear translocation and phosphorylation of transcription factor nuclear factor-κB (NF-κB) in both adult cardiomyocytes and HL-1 cells. Furthermore, immunoblotting analysis showed that 3PO inhibited LPS-induced apoptotic induction in cardiomyocytes. Taken together, these findings demonstrate that PFKFB3 participates in LPS-induced cardiac dysfunction via mediating inflammatory and apoptotic signaling pathway.

9.
J Colloid Interface Sci ; 536: 17-29, 2019 Feb 15.
Artigo em Inglês | MEDLINE | ID: mdl-30342408

RESUMO

Metal-free g-C3N4 is always limited by low surface area, rapid charge recombination and limited visible light absorption. In this study, novel porous nitrogen self-doped g-C3N4 nanosheets were prepared by a combination of N self-doping and thermal exfoliation process. Compared to the bulk g-C3N4, N self-doped g-C3N4 nanosheets possessed a high specific surface area of 74.79 m2 g-1, enhanced visible light absorption, improved photogenerated electron-holes separation, and prolonged lifetime of photogenerated charge carriers. As a consequence, N self-doped g-C3N4 nanosheets exhibited higher photocatalytic activity for tetracycline (TC) degradation than that of bulk g-C3N4, N self-doped g-C3N4 and g-C3N4 nanosheets. It also exhibited remarkable stability and repeatability. The detailed photocatalytic mechanism was proposed. The midgap states created by N doping can significantly enlarge the visible light absorption, reduce the recombination and prolong the lifetime of photogenerated charge carries. The nanosheet construction can provide increased surface area, abundant active sites, short charge diffusion distance, fast separation and promoted redox abilities of photoexcited charge carries.


Assuntos
Nanocompostos/química , Nitrilos/química , Nitrogênio/química , Tetraciclina/química , Catálise , Luz , Estrutura Molecular , Tamanho da Partícula , Processos Fotoquímicos , Porosidade , Propriedades de Superfície
10.
Genes Genet Syst ; 93(6): 221-228, 2019 Jan 19.
Artigo em Inglês | MEDLINE | ID: mdl-30541985

RESUMO

Human lifespan is determined by genetic and environmental factors. Potential longevity genes are neither specific nor reproducible, and longevity-related genes are constantly confused with age-related genes. To distinguish specific age- and longevity-related genes, we analyzed a Gene Expression Omnibus (GEO) dataset established by the Leiden Longevity Study. The individuals were classified into longevity (mean age, 93.4 ± 3.0 years), longevity offspring (60.8 ± 6.1) and control (61.9 ± 6.9) groups. The series matrix files were downloaded, and average expression values were calculated. Differentially expressed genes (DEGs) between longevity and control groups and those between longevity and their offspring were identified by GEO2R online. A total of 507 longevity- and 755 age-related DEGs were visualized using a Venn diagram. Weighted gene co-expression network analysis (WGCNA) was performed on the longevity- and age-related DEGs. Age-related color modules and genes were identified. However, no longevity-related modules or genes were found. The green module, with 46 age-related DEGs, was the most biologically significant to age and aging. Gene Ontology, Kyoto Encyclopedia of Genes and Genomes, and protein-protein interaction pathway analyses were conducted on these 46 DEGs, which are mainly enriched in B cell activation and receptor signaling pathways. CR2, VPREB3, MS4A1 and CCR6 were considered the most crucial candidate genes for aging.


Assuntos
Redes Reguladoras de Genes , Longevidade/genética , Transcriptoma , Idoso , Idoso de 80 Anos ou mais , Células Sanguíneas/metabolismo , Feminino , Perfilação da Expressão Gênica , Humanos , Masculino , Pessoa de Meia-Idade
11.
BMC Oral Health ; 18(1): 207, 2018 12 11.
Artigo em Inglês | MEDLINE | ID: mdl-30537963

RESUMO

BACKGROUND: With rapid urbanization in China, an increasing number of rural adults have migrated to cities to seek job opportunities, leaving their school-aged children behind. These left-behind children (LBC) without one or both parents usually receive less attention from their caregivers. Whether the parental migration affects the children's oral health is not well understood. This study aimed to explore the differences in dental caries status and oral health-related behaviors between children with different parental migration experiences in a rural area of Southern China. METHODS: A cross-sectional study was conducted in Luchuan County of Guangxi Province in 2015. A total of 1085 school children aged 8-12 participated in this study. Participants' demographic characteristics, parental migration information, and eating and oral hygiene habits were collected using a self-administered questionnaire. Dental caries of permanent teeth was examined using the decayed, missing, and filled tooth (DMFT) index recommended by the World Health Organization. Dental caries experience and oral health-related behaviors were compared between LBC and non-LBC, as well as children with different experiences of parental migrations. The impact of various parental migration attributes on LBC oral health outcomes was examined by univariate and multivariate analyses. RESULTS: Among the school-aged children examined, 60.9% of them were LBC. Only 29.7% of the children brushed their teeth regularly; 86.5% of them did not know what fluoride toothpaste was. Caries prevalence was 51.4% for LBC and 40.8% for non-LBC (p < 0.001). The LBC experienced a greater DMFT mean (1.20 ± 1.59) compared to the non-LBC (0.85 ± 1.30) (p < 0.001). Oral health-related behaviors were not significantly different between LBC and non-LBC. Dental caries experience and oral health-related behaviors were not related to the type or duration of parental migration. Multiple regression analyses showed that parental migration was one of significant predictors of children's caries outcome; LBC had a higher risk to caries than non-LBC (95% CI =1.26, 2.09). CONCLUSIONS: These findings indicate that parental migration could be a significant risk factor for caries development among 8- to 12-year-old school children in rural China.


Assuntos
Emigrantes e Imigrantes , Saúde Bucal/estatística & dados numéricos , Criança , China/epidemiologia , Estudos Transversais , Cárie Dentária/epidemiologia , Emigrantes e Imigrantes/estatística & dados numéricos , Feminino , Humanos , Masculino , Higiene Bucal/estatística & dados numéricos , Pais , Fatores de Risco , População Rural/estatística & dados numéricos , Inquéritos e Questionários
12.
PLoS One ; 13(9): e0202069, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30256805

RESUMO

BACKGROUND: In China, register nurses (RNs) have a high risk of occupational exposure to blood/body fluids. The adherence behavior related to self-reporting of occupational exposure needs to be evaluated to protect RNs from healthcare-related infections. OBJECTIVES: To assess adherence behaviors for self-reporting of occupational exposure to blood and body fluids among RNs and identify factors affecting self-reporting in Hunan Province, China for developing upgraded strategies. METHODS: Study participants, randomly selected from six tertiary hospitals in Changsha City, completed a structured questionnaire. Frequencies and percentages were used to describe basic demographic data. One-way analysis of variance was performed to assess whether adherence behaviors were correlated to each other; the multivariate logistic regression analysis was performed to identify factors associated with reporting exposure to blood/body fluids. RESULTS: In total, 548 RNs completed the questionnaire. All participants experienced sharp object injuries at least once during their career; 65.88% of participants were exposed to blood/body fluids thrice, and 31.2% experienced 1-5 occupational exposures in the past month. However, only 14.6% of participants submitted a blood/body fluid exposure report to a supervisor/official after every incident. Blood/body fluid exposure was associated with the non-usage of safety protocols. Only 10.2% of participants believed the employer paid more attention to needle-stick injuries (P<0.01) than to other injuries. Most participants (73.5%) reported the absence of psychological support after injuries (P<0.01). Nine personal and management factors were observed to be closely related to underreporting behavior. CONCLUSION: The prevalence of exposure to blood/body fluids among RNs was high, and the underreporting rate was likely substantially underestimated. Safety-engineered devices must be adopted to decrease the prevalence of sharp object injuries. To encourage employees to report occupational exposure events, a series of hospital-wide actions need to be adopted.


Assuntos
Sangue , Comportamentos Relacionados com a Saúde , Enfermeiras e Enfermeiros , Exposição Ocupacional/efeitos adversos , Autorrelato , Inquéritos e Questionários , Adulto , China , Estudos Transversais , Feminino , Humanos , Masculino , Prevalência
13.
Zhongguo Zhong Yao Za Zhi ; 43(13): 2648-2653, 2018 Jul.
Artigo em Chinês | MEDLINE | ID: mdl-30111012

RESUMO

In order to explore the correlation between the medicinal properties,efficacy and application in the same genetic relationship,explain the scientific connotation of the medicinal properties and effects of traditional Chinese medicines(TCM),promote the academic development of the theory of traditional Chinese medicines,and provide reference for the research and development of the traditional Chinese medicines of a same genus. In this paper, a literature study of ancient and modern works of Chinese herbal medicine was conducted to investigate the correlation between the properties, meridians tropism, efficacy and application of Alpinia officinarum, A. katsumadai, Galangae Fructus and Alpinae Oxyphyllae Fructus, four kinds of Alpinia Chinese medicines.The results showed that the similar properties of these four kinds of Alpinia Chinese medicines included that they were acrid, warm,and mainly getting into the spleen and stomach channels; the similar efficacies included that dispelling cold,relieving pain,warming stomach,anti-nausea,anti-diarrheal,reinforcing spleen to promote digestion and other effects; in application aspects, the similarities were that they were all mainly used in treatment of catching cold or spleen deficiency induced by abdominal pain,vomiting,diarrhea,diet indigestion, etc. indicating that phylogenetic relationship was closely related with the herbal properties, efficacy and application. It is an effective way to explore,collate and research traditional Chinese medicine by using plant phylogenetic relationships in exploring the internal relations and laws of TCM theories,material bases, pharmacological effects and clinical applications, also with a strong maneuverability to explain their scientific connotation.


Assuntos
Alpinia , Medicamentos de Ervas Chinesas , Meridianos , Medicina Tradicional Chinesa , Filogenia
14.
Medicine (Baltimore) ; 97(23): e10446, 2018 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-29879012

RESUMO

BACKGROUND: CD133 has been identified as a putative cancer stem cell marker in colorectal cancer (CRC). However, the clinicopathological and prognostic significance of CD133 in CRC patients remains controversial. Thus, we conducted a meta-analysis to quantitatively evaluate the above issues. METHODS: We collected a comprehensive literature search from PubMed, Web of Science, and Embase database up to September 20, 2016 examining CD133 and clinical features of colorectal cancer patients. We used the odds ratio (OR) with 95% confidence interval (CI) to estimate the effects by overall and stratified analysis. RESULTS: The overall result of our meta-analysis indicated that CD133 expression was positively correlated with T category, distant metastasis, lymphatic invasion, and vascular invasion. Moreover, patients with higher CD133 expression had a poorer overall survival (OS) (HR=2.01, P < .001) and a lower 5-year OS rate (OR = 3.26, P < .001) than those with lower expression. Disease-free survival (DFS) and 5-year DFS rate were similar with the above results. Though the correlation between CD133 expression with the clinical characteristic was not positive in some ways when we analyzed the different subgroup. The prognostic value of CD133 expression for 5-year OS rate of CRC patients was noticeable in spite of different patients' region, multiple antibodies used in studies, various cut-off values of CD133 expression, and adjuvant therapy situation of patients. CONCLUSION: CD133 is a useful predictive or prognostic biomarker for CRC in clinical assessment and may serve as a potential therapeutic target for CRC.


Assuntos
Antígeno AC133/metabolismo , Biomarcadores Tumorais/metabolismo , Neoplasias Colorretais/metabolismo , Neoplasias Colorretais/mortalidade , Neoplasias Colorretais/patologia , Humanos , Prognóstico , Taxa de Sobrevida
15.
Arch Osteoporos ; 13(1): 65, 2018 06 09.
Artigo em Inglês | MEDLINE | ID: mdl-29886557

RESUMO

OBJECTIVES: To explore the prevalence and ethnic differences of osteosarcopenic obesity (OSO) and dyslipidemia and their relationship among Maonan, Mulam, Hmong, and Yao minorities in China. METHODS: A total of 2315 Maonan, Mulam, Hmong, and Yao women aged 20-95 from Guangxi were included in this study. Questionnaire survey was carried out and their blood lipids were tested. Body compositions were measured by bioelectrical impedance analysis, and T-score was assessed by ultrasonic examination, respectively. RESULTS: Our study showed ethnic-specific prevalence of OSO. In older women, the incidence rates of OSO in Mulam were 4.9, 12.6, and 11.5% in Maonan, Mulam, and Hmong ethnicity, respectively. In younger group, the incidence rates of OSO were 0.4, 0.4, and 0.6%, respectively. However, there is no prevalence of OSO in Yao women in two groups. The prevalence of dyslipidemia in younger women was 22.86, 29.89, 43.35, and 80.00% in group numbering one, two, and three, respectively. In older women, it was 29.13, 39.02, 41.37, and 52.38%, respectively. Based on logistic regression analysis, after controlling for covariates, dyslipidemia in younger group was positively associated with a higher number of adverse body composition, especially for OSO (OR = 12.53, 95%CI 1.34-116.99). Compared with normal women, OSO women in older group were also more likely to have dyslipidemia (OR = 6.75, 95%CI 3.19-14.31). CONCLUSION: OSO may be a risk factor for dyslipidemia in the ethnic groups. Thus, efforts to promote healthy aging should be focused on preventing obesity and maintaining bone health and muscle mass.


Assuntos
Composição Corporal/fisiologia , Dislipidemias/etnologia , Grupos Étnicos , Obesidade/etnologia , Sarcopenia/etnologia , Adulto , Idoso , Idoso de 80 Anos ou mais , China/epidemiologia , Dislipidemias/sangue , Dislipidemias/complicações , Feminino , Humanos , Pessoa de Meia-Idade , Obesidade/sangue , Obesidade/etiologia , Prevalência , Fatores de Risco , Sarcopenia/sangue , Sarcopenia/complicações , Inquéritos e Questionários , Adulto Jovem
16.
Bioresour Technol ; 262: 294-301, 2018 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-29729607

RESUMO

In this study, zero valent iron (ZVI) activated peroxymonosulfate (PMS) as novel technique (i.e. ZVI-PMS technology) was employed to enhance sludge dewatering. In optimal sludge dewatering conditions of ZVI and KHSO5 dosages, the specific resistance to filtration (SRF) was reduced by 83.6%, which was further decreased to 90.6% after combination of ZVI-PMS with thermal treatment at 50 °C (i.e. ZVI-PMS-T technology). Subsequently, the ESR spectrum and quenching tests demonstrated that OH, rather than SO4-, was predominant radicals in ZVI-PMS conditioning. Thereafter, the variation of physicochemical properties and the distributions and compositions of extracellular polymeric substances (EPS) were further investigated to uncover the influence of these techniques on sludge bulk properties. The results indicated that sludge particles were disintegrated into smaller particles and surface charges were neutralized, sludge flowability were elevated obviously after treatments. In ZVI cycle experiment, the high dewatering efficiency was maintained by ZVI-PMS and ZVI-PMS-T pretreatment.


Assuntos
Ferro/química , Peróxidos , Oxirredução , Esgotos , Eliminação de Resíduos Líquidos
17.
Cell Physiol Biochem ; 46(4): 1716-1726, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-29730663

RESUMO

BACKGROUND/AIMS: Relevant markers of cancer stem cells (CSCs) may serve as commonly used biomarkers of ovarian cancer (OC). However, their actual clinicopathological and prognostic significance remains inconclusive. Thus, we conducted a meta-analysis to quantitatively evaluate the association between the expression of CSC-relevant markers (ALDH1, CD117, CD133, and CD44) and OC. METHODS: We used an odds ratio (OR) and a hazard ratio (HR) with a 95% confidence interval (CI) to estimate the effects by analyzing 52 studies from a literature search. Heterogeneity and sensitivity were evaluated, as well. Publication bias was assessed using funnel plots and Egger tests. RESULTS: ALDH1 expression was statistically associated with FIGO stage (OR=1.872, 95%CI=1.14-3.076, P=0.013) and lymph invasion (OR=2.78, 95%CI=1.08-7.152, P=0.034). CD117 expression was significantly associated with FIGO stage (OR=2.01, 95%CI=1.35-2.98, P=0.001). CD133 expression was correlated with FIGO stage (OR=3.410, 95%CI=2.196-5.294, P< 0.001) and differentiation grade (OR=2.672, 95%CI=1.354-5.272, P=0.005). CD44s was related to chemotherapy resistance (OR=3.218, 95%CI=1.148-9.016, P=0.026). Furthermore, overexpression of ALDH1 (HR=1.494, 95%CI=1.207-1.849, P< 0.001), CD117 (HR=1.395, 95%CI=1.025-1.898, P=0.034) or CD44s (HR=1.725, 95%CI=1.135-2.623, P=0.011) was associated with poor OS. Further, overexpression of both ALDH1 (HR=1.524, 95%CI=1.158-2.007, P=0.003) and CD44s (HR=2.12, 95%CI=1.692-2.657, P< 0.001) was correlated with worse DFS. CONCLUSION: CSC markers are useful predictive or prognostic biomarkers for OC in clinical assessments. Combined detection of CSC marker expression may be a powerful tool for prognostic predictions in clinical practice for patients with OC.


Assuntos
Biomarcadores Tumorais/metabolismo , Células-Tronco Neoplásicas/metabolismo , Neoplasias Ovarianas/patologia , Antígeno AC133/genética , Antígeno AC133/metabolismo , Biomarcadores Tumorais/genética , Bases de Dados Factuais , Intervalo Livre de Doença , Resistencia a Medicamentos Antineoplásicos , Feminino , Humanos , Receptores de Hialuronatos/genética , Receptores de Hialuronatos/metabolismo , Isoenzimas/genética , Isoenzimas/metabolismo , Razão de Chances , Neoplasias Ovarianas/metabolismo , Neoplasias Ovarianas/mortalidade , Prognóstico , Modelos de Riscos Proporcionais , Proteínas Proto-Oncogênicas c-kit/genética , Proteínas Proto-Oncogênicas c-kit/metabolismo , Retinal Desidrogenase/genética , Retinal Desidrogenase/metabolismo , Taxa de Sobrevida
18.
Cell Physiol Biochem ; 47(1): 414-427, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-29794444

RESUMO

BACKGROUND/AIMS: CTLA-4 polymorphisms are associated with susceptibility to various cancers, but the results are often conflicting. Hence, we performed a comprehensive meta-analysis to quantitatively investigate the association between CTLA-4 polymorphisms (rs231775, rs4553808,rs5742909, rs3087243 or rs733618) and cancer risk. METHODS: Data were collected from PubMed and Web of Science. A total of 67 case-control studies were selected for quantitative analysis. Stata (Version 12) software was used to calculate the odds ratio (OR) and 95% confidence interval (CI) to evaluate the strength of the associations. Subgroup meta-analysis was conducted based on ethnicity and cancer type. Heterogeneity tests, sensitivity analysis, and publication bias assessments were also performed. RESULTS: rs231775, rs4553808 and rs5742909 but not rs3087243 and rs733618 were significantly related to cancer risk. In analyses stratified by ethnicity, both rs231775 and rs4553808 were significant susceptibility polymorphisms in an Asian population but not in a Caucasian population. Moreover, there were stronger associations between the rs231775 polymorphism and increased risk of bone, breast, liver, head and neck and pancreatic cancers. Additionally, rs4553808 was associated with significantly increased susceptibility to breast cancer and head and neck cancer. CONCLUSION: rs231775, rs4553808 and rs5742909 may be used as predictive genetic biomarkers for cancer predisposition. Combined detection of CTLA-4 SNPs could be a useful tool for prediction of cancer susceptibility in clinical practice.


Assuntos
Antígeno CTLA-4/genética , Neoplasias/genética , Polimorfismo de Nucleotídeo Único , Grupo com Ancestrais do Continente Asiático/genética , Estudos de Casos e Controles , Grupo com Ancestrais do Continente Europeu/genética , Predisposição Genética para Doença , Genótipo , Humanos , Neoplasias/epidemiologia , Viés de Publicação
19.
Bioresour Technol ; 260: 115-123, 2018 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-29625282

RESUMO

Effect of hydrothermal carbonization (HTC) on the hydrochar pelletization and the aldehydes/ketones emission from pellets during storage was investigated. Pellets made from the hydrochar were stored in sealed apparatuses for sampling. The energy consumption during pelletization and the pellets' properties before/after storage, including dimension, density, moisture content, hardness, aldehyde/ketones emission amount/rate and unsaturated fatty acid amount, were analyzed. Compared with untreated-sawdust-pellets, the hydrochar-pellets required more energy consumption for pelletization, and achieved the improved qualities, resulting in the higher stability degree during storage. The species and amount of unsaturated fatty acids in the hydrochar-pellets were higher than those in the untreated-sawdust-pellets. The unsaturated fatty acids content in the hydrochar-pellets was decreased with increasing HTC temperature. Higher aldehydes/ketones emission amount and rates with a longer emission period were found for the hydrochar-pellets, associated with variations of structure and unsaturated fatty acid composition in pellets.


Assuntos
Aldeídos , Cetonas , Carbono , Meio Ambiente , Madeira
20.
Hepatobiliary Pancreat Dis Int ; 17(2): 101-112, 2018 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-29567047

RESUMO

BACKGROUND: Augmented reality (AR) technology is used to reconstruct three-dimensional (3D) images of hepatic and biliary structures from computed tomography and magnetic resonance imaging data, and to superimpose the virtual images onto a view of the surgical field. In liver surgery, these superimposed virtual images help the surgeon to visualize intrahepatic structures and therefore, to operate precisely and to improve clinical outcomes. DATA SOURCES: The keywords "augmented reality", "liver", "laparoscopic" and "hepatectomy" were used for searching publications in the PubMed database. The primary source of literatures was from peer-reviewed journals up to December 2016. Additional articles were identified by manual search of references found in the key articles. RESULTS: In general, AR technology mainly includes 3D reconstruction, display, registration as well as tracking techniques and has recently been adopted gradually for liver surgeries including laparoscopy and laparotomy with video-based AR assisted laparoscopic resection as the main technical application. By applying AR technology, blood vessels and tumor structures in the liver can be displayed during surgery, which permits precise navigation during complex surgical procedures. Liver transformation and registration errors during surgery were the main factors that limit the application of AR technology. CONCLUSIONS: With recent advances, AR technologies have the potential to improve hepatobiliary surgical procedures. However, additional clinical studies will be required to evaluate AR as a tool for reducing postoperative morbidity and mortality and for the improvement of long-term clinical outcomes. Future research is needed in the fusion of multiple imaging modalities, improving biomechanical liver modeling, and enhancing image data processing and tracking technologies to increase the accuracy of current AR methods.


Assuntos
Doenças Biliares/cirurgia , Procedimentos Cirúrgicos do Sistema Biliar/métodos , Hepatectomia/métodos , Laparoscopia/métodos , Hepatopatias/cirurgia , Modelagem Computacional Específica para o Paciente , Procedimentos Cirúrgicos Robóticos/métodos , Doenças Biliares/diagnóstico por imagem , Procedimentos Cirúrgicos do Sistema Biliar/efeitos adversos , Hepatectomia/efeitos adversos , Humanos , Imagem Tridimensional , Laparoscopia/efeitos adversos , Hepatopatias/diagnóstico por imagem , Imagem por Ressonância Magnética , Interpretação de Imagem Radiográfica Assistida por Computador , Procedimentos Cirúrgicos Robóticos/efeitos adversos , Tomografia Computadorizada por Raios X
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