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Osteoporos Int ; 2020 Jan 30.
Artigo em Inglês | MEDLINE | ID: mdl-32002571


By Bayesian random effects network meta-analysis stratified by prevalent vertebral fracture (PVF), we conclude that different effective drugs should be used to prevent fragility fractures according to postmenopausal women with or without PVF and that there are two drugs (i.e., parathyroid hormone (1-84) and abaloparatide) less tolerated than placebo. INTRODUCTION: No studies have compared various osteoporosis drugs in postmenopausal women (PMW) either with or without prevalent vertebral fracture (PVF). We aimed to compare them in the two different subgroups. METHODS: We searched different databases to select relevant studies. We performed Bayesian random effects network meta-analysis to synthesize hazard ratio (HR) and 95% confidence interval (CI) for clinical fracture stratified by PVF and to synthesize risk ratio (RR) for tolerability and vertebral fracture. RESULTS: We included 33 trials involving 79,144 PMW. In the PVF ≥ 50% subgroup, teriparatide (HR 0.39, 95% CI 0.28-0.57), romosozumab (HR 0.49, 95% CI 0.29-0.75), risedronate (HR 0.62, 95% CI 0.50-0.79), zoledronate (HR 0.67, 95% CI 0.47-0.96), and alendronate (HR 0.69, 95% CI 0.47-0.97) reduced clinical fracture risk. In the other subgroup, abaloparatide (HR 0.56, 95% CI 0.33-0.92), romosozumab (HR 0.67, 95% CI 0.47-0.95), and denosumab (HR 0.68, 95% CI 0.50-0.85) reduced clinical fracture risk. Five drugs reduced vertebral fracture risk in the PVF ≥ 50% subgroup whereas seven did in the other subgroup. All drugs did not increase withdrawal risk except for parathyroid hormone (1-84) (PTH) (RR 1.9, 95% CI 1.4-2.6) and abaloparatide (RR 1.6, 95% CI 1.2-2.3). CONCLUSION: Different effective drugs should be used to prevent fragility fractures according to PMW with or without PVF, and romosozumab is the only one which can reduce clinical and vertebral fractures in both of the two populations. PTH and abaloparatide are less tolerated than placebo whereas the eight other drugs assessed in the study have the same tolerability as placebo.

Fa Yi Xue Za Zhi ; 35(5): 572-575, 2019 Oct.
Artigo em Inglês, Chinês | MEDLINE | ID: mdl-31833291


Abstract: Objective To study the mechanism of change of the electrical conductivity (EC) of rat skeletal muscle impregnating solution that occurs with the change of postmortem interval (PMI). Methods Healthy Sprague-Dawley rats were killed and kept at about 25 ℃. Skeletal muscles were extracted at different PMI--immediate (0 d), 1 d, 2 d, 3 d, 4 d, 5 d, 6 d, and 7 d, then mixed with deionized water to make impregnating solution with a mass concentration of 0.1 g/mL. The solution's EC and nine common chemicals in it, such as potassium ion, calcium ion, and chloride ion, were determined. Results EC increased gradually with the extending of PMI (P=0.024) during the 7 days after the rats' death. The content of uric acid (P=0.032), urea nitrogen (P=0.013) and phosphorus (P=0.022) also increased during the extension. However, the content of magnesium ions decreased with extending of PMI (P=0.047). The correlation between potassium ion, sodium ion, chlorine ion, calcium ion, creatinine and PMI were weak (P>0.05). Conclusion The molecular basis of skeletal muscle EC change in rats after their death is the changes of uric acid, urea nitrogen, inorganic phosphorus and other chemical components. Furthermore, combine use of various indicators can improve the accuracy of the EC method to infer PMI.

Condutividade Elétrica , Patologia Legal , Músculo Esquelético , Mudanças Depois da Morte , Animais , Ratos , Ratos Sprague-Dawley , Fatores de Tempo
Zhonghua Wei Chang Wai Ke Za Zhi ; 22(12): 1118-1123, 2019 Dec 25.
Artigo em Chinês | MEDLINE | ID: mdl-31874526


As the rapid development of minimally invasive techniques, anesthesia, and enhanced recovery after surgery (ERAS), anorectal day surgery receiving more and more attention by improving efficiency of medical care while reducing cost and hospitalized infection. However, day surgery also faces the challenge of completing the whole process from patient admission to discharge within 24 hours. Therefore, establishing a reasonable and detailed day surgery process is the cornerstone to guarantee safe medical practice and patients satisfaction. National Clinical Research Center for Geriatric Disorders (Xiangya), together with China Ambulatory Surgery Alliance formulates the clinical practice guideline for anorectal day surgery 2019 edition. Here we make some interpretations of the guidelines on the detailed process of anorectal day surgery, including indication, preoperative examination, preoperative risk evaluation, health education, assessment of day surgery anesthesia and before leaving postanesthesia care unit (PACU), postoperative management, assessment of discharge and follow-up, for the convenience of various medical centers.

Procedimentos Cirúrgicos Ambulatórios/normas , Assistência ao Paciente/normas , Guias de Prática Clínica como Assunto/normas , Protectomia/normas , Idoso , Canal Anal/cirurgia , Humanos , Reto/cirurgia
Zhonghua Nei Ke Za Zhi ; 58(11): 814-818, 2019 Nov 01.
Artigo em Chinês | MEDLINE | ID: mdl-31665856


Objective: To investigate the clinical significance of transcranial Doppler (TCD) in early diagnosis of sepsis-associated encephalopathy(SAE). Methods: Septic patients admitted to the intensive care unit(ICU) were recruited at Xiangya Hospital, Central South University from July 2015 to March 2016. Clinical data and TCD parameters during 24 hours after admission were collected. All patients were screened for delirium using the confusion assessment method for the intensive care unit (CAM-ICU) twice a day. The gold standard of the diagnosis of SAE was positive CAM-ICU evaluation. Patients were divided into SAE group and the non-SAE group. TCD data including systolic velocity (Vs), diastolic velocity (Vd), mean velocity (Vm), pulsatility index (PI) and resistant index (RI) were analyzed to determine the optimal diagnostic cut-off value. Results: A total of 43 patients were enrolled including 12 in SAE group and 31 in non-SAE group. Vm and Vd were lower in SAE group [Vm: (53.50±12.22) cm/s vs. (61.68±9.63) cm/s, P<0.05; Vd: (33.42±10.87) cm/s vs. (43.16±7.84) cm/s, P<0.01] but PI and RI were significant higher in SAE group[PI:(1.16±0.2) vs. (0.90±0.15), P<0.01;RI:(0.65±0.08) vs. (0.56±0.06), P<0.01] than in non-SAE group. The cut-off values of Vs, Vm, Vd, PI and RI for the diagnosis of SAE were 112cm/s, 55.50cm/s, 34.50cm/s, 1.16, 0.65, respectively, with the relevant sensitivities of 19.4%, 83.9%, 93.5%, 58.3%, 58.3% and the specificities of 100.0%, 50.0%, 58.3%, 96.8%, 96.8%, respectively. The diagnostic AUC of Vd, PI and RI were 0.741, 0.808 and 0.808 respectively. Conclusions: The parameter changes of TCD suggest that the pathogenesis of SAE is related to cerebral hypoperfusion, TCD is a helpful method for the early diagnosis of SAE.

Circulação Cerebrovascular , Artéria Cerebral Média/diagnóstico por imagem , Encefalopatia Associada a Sepse/diagnóstico por imagem , Ultrassonografia Doppler Transcraniana/métodos , Velocidade do Fluxo Sanguíneo , Estudos de Casos e Controles , Diagnóstico Precoce , Humanos , Unidades de Terapia Intensiva
Zhonghua Nei Ke Za Zhi ; 58(10): 751-757, 2019 Oct 01.
Artigo em Chinês | MEDLINE | ID: mdl-31594173


Objective: To investigate the characteristics of body composition (BC) in gout patients and its clinical significance. Methods: Consecutive gout patients were recruited between August 2017 and December 2018. Demographic information, clinical characteristics and comorbidities were collected. BC was assessed by bioelectric impedance analysis including body fat percentage (BF%), trunk and limb BF%, appendicular skeletal muscle index. Overfat was defined by BF% ≥25% for male and ≥35% for female. The association between BC and serum uric acid (sUA) was evaluated by multiple linear regression. Results: A total of 362 gout patients were recruited with median age 38 (30, 52) years, 96.1% (348/362) were male. Mean sUA was (551±133) µmol/L. The mean BF% was (25.8±6.4)% with 53.6%(194/362) patients overfat. Male gout patients with overfat showed more affected joints [4(2, 6) vs. 2(2, 5)], higher sUA [(576±126)µmol/L vs. (523±134) µmol/L], higher prevalence of dyslipidemia [70.1%(131/187) vs. 54.0%(87/161)], metabolic syndrome [60.8%(118/187) vs. 28.0%(47/161)], fatty liver [58.2%(113/187) vs. 35.1%(59/161)] and hypertension [44.4%(83/187) vs. 25.5%(41/161)] than male patients with normal fat (all P<0.05). Their BF%, trunk BF% and limb BF% were positively correlated with the numbers of affected joints, sUA, metabolic syndrome, fatty liver, and hypertension, respectively (r=0.154-0.435, all P<0.05). Multivariable linear regression suggested that BF% (ß=4.29, P=0.020) and trunk BF% (ß=9.11, P=0.007), but not limb BF%, were positively correlated with sUA. Conclusion: Overfat is very common in gout patients. The proportion of trunk fat in male patients is positively correlated with sUA. When assessing obesity in gout patients clinically, body composition analysis should be performed simultaneously.

Composição Corporal/fisiologia , Gota/diagnóstico , Obesidade/epidemiologia , Ácido Úrico/sangue , Adulto , Dislipidemias/epidemiologia , Feminino , Gota/sangue , Gota/epidemiologia , Humanos , Hipertensão/sangue , Hipertensão/epidemiologia , Masculino , Pessoa de Meia-Idade , Hepatopatia Gordurosa não Alcoólica/sangue , Hepatopatia Gordurosa não Alcoólica/epidemiologia , Obesidade/sangue , Prevalência
Fa Yi Xue Za Zhi ; 35(4): 393-395, 2019 Aug.
Artigo em Inglês, Chinês | MEDLINE | ID: mdl-31532144


Abstract: Objective To explore the relationship between the electrical conductivity (EC) and biochemical indicators of rat cerebrum tissues and postmortem intervals (PMIs) and discuss the mechanism of applying EC to infer PMI. Methods Forty healthy Sprague-Dawley rats were sacrificed and stored in an environment of about 25 ℃. The whole cerebrum tissues of rats were removed respectively at different PMIs of 0, 1, 2, 3, 4, 5, 6, and 7 d, and then made into homogenized impregnation solution. The EC and related biochemical indicators (potassium, sodium, chloride, calcium, inorganic phosphorus, magnesium, uric acid, urea nitrogen and creatinine) in cerebrum tissue impregnation solution were determined, and the relationships among EC in impregnation solution, related biochemical indicators and PMI were analyzed. Results The EC in cerebrum tissues increased gradually with the extension of PMI, and the content of uric acid, urea nitrogen and inorganic phosphorus in its impregnation solution also increased gradually with the extension of PMI. The correlation of EC, uric acid, urea nitrogen, and inorganic phosphorus with PMI was relatively good (R2 was 0.95-0.99), and there was a linear correlation between the content change of uric acid, urea nitrogen, inorganic phosphorus and EC (R2 was 0.97-0.99). The changes of the other 6 kinds of biochemical indicators with the extension of PMI within 7 d after the rats' death were non-significant (P>0.05). Conclusion The correlation between EC in cerebrum tissues, uric acid, urea nitrogen, inorganic phosphorus and PMI were relatively good, and combining various indicators can also improve the accuracy of PMI estimation.

Cérebro/patologia , Condutividade Elétrica , Mudanças Depois da Morte , Animais , Patologia Legal , Ratos , Ratos Sprague-Dawley , Fatores de Tempo
Zhonghua Shao Shang Za Zhi ; 35(7): 557-559, 2019 Jul 20.
Artigo em Chinês | MEDLINE | ID: mdl-31357831


The 15th Syposium on Chinese Burn Medicine and the 2nd Congress of Burn Medicine Branch of China International Exchange and Promotion Association for Medical and Healthcare (CPAM) was successfully held in Suzhou, from June 20th to 22th in 2019. A total of 400 specialists and scholars across the country attended the meeting. Focusing on the theme of " Guide and consensus: exploration and consideration " , with form of one main meeting place and two branch meeting places, the related hot and difficult problems were discussed warmly. During the conference, Working Conference of Editorial Committee of Chinese Journal of Burns, Standing Committee of the Chinese Burn Association, and the Congress of Burn Medicine Branch of CPAM were held.

Queimaduras , China , Congressos como Assunto , Humanos
Zhonghua Shao Shang Za Zhi ; 35(5): 398-399, 2019 May 20.
Artigo em Chinês | MEDLINE | ID: mdl-31154742


The Working Conference of Editor-in-Chief, sponsored by the Editorial Committee of Chinese Journal of Burns, was successfully held in Guiyang, Guizhou Province, from April 10th to 12th 2019. Consultant for life, honorary editor-in-chief, editor-in-chief, deputy editor-in-chief, and members of the standing committee gave effective proposal involving construction and development of journal, planning scheme for 20th anniversary celebration of journal, and future work plan.

Queimaduras , Congressos como Assunto , Publicações Periódicas como Assunto/história , Editoração/história , Aniversários e Eventos Especiais , China , Políticas Editoriais , História do Século XX , História do Século XXI , Humanos
Zhonghua Er Ke Za Zhi ; 57(6): 465-470, 2019 Jun 02.
Artigo em Chinês | MEDLINE | ID: mdl-31216805


Objective: To investigate the echocardiographic features of fetal Ebstein's anomaly (EA) and to analyze its clinical outcome and prognosis. Methods: A retrospective case-control study was conducted to analyze the echocardiographic features in fetus with EA. Thirty-five EA fetuses (EA group) and 35 normal fetuses matched for gestational age (control group) were enrolled. The main echocardiographic parameters of the two groups were collected and compared. According to the direction of blood flow in the ductus arteriosus (DA),fetuses in EA group were divided into DA reverse perfusion subgroup (n=11) and normal DA blood flow subgroup (n=24). The echocardiographic parameters and GOSE scores were compared between the two subgroups. The echocardiographic features of EA and the difference of fetal hemodynamics were summarized,and the clinical outcome of EA fetus was evaluated by GOSE score. Chi-square test Rank sum test or t test were used for comparison between groups. Results: Nineteen (54%) of the 35 patients terminated the pregnancy and 16 (46%) continued pregnancy until delivery during follow-up. Compared with the normal fetus group,the cardiothoracic ratio was significantly higher (0.47±0.11 vs. 0.34±0.01, t=6.640, P<0.01) and the transverse diameter ratio of right atrium to left atrium was significantly greater (1.42±0.38 vs. 1.08±0.11, t=5.030, P<0.01) in the EA group, and the ratio of pulmonary artery diameter to aortic diameter was significantly lower in the EA group (1.04±0.21 vs. 1.20±0.15, t=-3.770, P<0.01). Compared with the normal DA blood flow subgroup,the GOSE scores ≥ 1.5 was more frequently seen (7/11 vs. 3/24, P=0.004) and the ratio of pulmonary artery diameter to aortic diameter was significantly lower (0.91±0.18 vs. 1.24±0.20, t=-4.696, P=0.002) in the DA reverse perfusion subgroup. Six of the 16 delivery cases underwent EA corrective surgery after birth with 100% successful rate of operation. Among the 6 cases,two had preoperative GOSE score of ≥1.5 who were considered as severe cases,and four had low GOSE score of<1.5. The remaining ten cases who had not undergone the corrective surgery were followed up routinely. Conclusion: Prenatal hemodynamics of EA combined with GOSE score can more accurately evaluate the severity and prognosis of fetal EA, reduce unnecessary labor induction, and improve postpartum cure rate and clinical outcomes.

Anomalia de Ebstein/diagnóstico por imagem , Diagnóstico Pré-Natal , Ultrassonografia Pré-Natal/métodos , Ultrassonografia/métodos , Estudos de Casos e Controles , Feminino , Humanos , Cuidado Pós-Natal , Gravidez , Cuidado Pré-Natal , Prognóstico , Estudos Retrospectivos
Fa Yi Xue Za Zhi ; 35(2): 181-186, 2019 Apr.
Artigo em Inglês, Chinês | MEDLINE | ID: mdl-31135112


Abstract: Objective To assess the feasibility of using 28S ribosomal RNA (28S rRNA) and mitochondrial cytochrome c oxidase subunit Ⅰ (COⅠ) gene sequences of nine necrophagous Calliphorid flies for the identification of common necrophagous Calliphorid flies, and to provide technical support for postmortem interval (PMI) estimation. Methods Twenty-three Calliphorid flies were collected and identified morphologically, and DNA were extracted from legs. The gene fragments of 28S rRNA and COⅠ were amplified and sequenced, then the sequence alignment was performed with BLAST. The composition of obtained sequences was analyzed and evolutionary divergence rate between species and intraspecies were established. The phylogeny tree was constructed with neighbor-joining method. Results The 23 necrophagous Calliphorid flies were identified to 9 species of 5 genera. The 715 bp from 28S rRNA and 637 bp from COⅠ gene were obtained and the online BLAST result showed more than 99% of similarity. The phylogeny tree showed that the necrophagous flies could cluster well into 9 groups, which was consistent with morphological identification results. The intraspecific difference in 28S rRNA was 0 and the interspecific difference was 0.001-0.033. The intraspecific difference in COⅠ was 0-0.008 and the interspecific difference was 0.006-0.101. Conclusion Combined use of 28S rRNA and COⅠ gene sequence fragments can effectively identify the nine Calliphorid flies in this study. However, for closely related blowfly species, more genetic markers should be explored and used in combination in future.

DNA Mitocondrial/genética , Dípteros/genética , RNA Ribossômico 28S/genética , Animais , Dípteros/classificação , Filogenia , Análise de Sequência de DNA , Especificidade da Espécie
Zhonghua Xin Xue Guan Bing Za Zhi ; 47(5): 374-380, 2019 May 24.
Artigo em Chinês | MEDLINE | ID: mdl-31142081


Objective: To evaluate the efficacy and safety of low dose sublingual nifedipine dripping pills (5 mg) in treating moderate and severe hypertension in comparison with normal dose (10 mg) of sublingual nifedipine dripping pills. Methods: This study was designed as a randomized, double-blind, positive drug parallel controlled, multi-center, non-inferiority clinical trial. Patients with moderate and severe hypertension were enrolled by 14 clinical trial centers, randomly divided into the trial group (sublingual 5 mg nifedipine dripping pills) and the control group (sublingual 10 mg nifedipine dripping pills). The changes in blood pressure were monitored continuously within 2 hours after the initial administration, repeated the dose in 20 minutes interval after the initial administration for up to additional 3 doses (maximum 4 doses) if the antihypertensive efficacy was not satisfactory. The efficacy of antihypertensive therapy between the two groups was evaluated by repeated administration rates and blood pressure changes at 60 minutes post the initial administration, and the safety of treatment was evaluated by recording adverse event rate of the two groups. Results: The anti-hypertensive effective rates at 60 minutes after sublingual administration were 83.5% (202/242) and 86.7% (208/240) respectively between the trial group and control group (χ(2)=1.307, P=0.253) . On the aspect of antihypertensive effectiveness at 60 minutes after single dose of sublingual administration, the anti-hypertension effective rates of the trial group and the control group were 85.6% (154/180) and 87.2% (164/188) respectively (χ(2)=0.221, P=0.639). Prevalence of the repeated administration was also similar between the two groups (25.6%(62/242) in the trial group and 21.7% (52/240) in the control group, χ(2)=1.043, P=0.307). On the safety aspect, there was no adverse events/reactions in the trial group, but there were 15 cases of adverse events/reactions occurred in control group (6.25%, χ(2)=15.611, P<0.001). Conclusions: In the treatment of moderate to severe hypertension, the antihypertensive efficacy of low dose nifedipine dripping pills is similar to that of conventional dosage, and the safety profile of low dose nifedipine dripping pills is better than that of the conventional dose.

Anti-Hipertensivos , Hipertensão , Nifedipino , Administração Sublingual , Anti-Hipertensivos/administração & dosagem , Pressão Sanguínea , Método Duplo-Cego , Humanos , Hipertensão/tratamento farmacológico , Nifedipino/administração & dosagem
Zhonghua Nei Ke Za Zhi ; 58(3): 215-217, 2019 Mar 01.
Artigo em Chinês | MEDLINE | ID: mdl-30803182
Transfusion ; 59(4): 1183-1189, 2019 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-30720868


BACKGROUND: Alloantibodies against more than 50 non-ABO blood group antigens have been implicated in hemolytic disease of the fetus and newborn (HDFN) and are expected to wane within weeks after delivery. Persistent anemia leads to the hypothesis of continued exposure to red blood cell (RBC) alloantibodies via breast milk, which has been shown in a murine model and suggested in rare case reports. CASE REPORT: We report three cases of prolonged HDFN in two neonates with anti-D HDFN and one with anti-Jka HDFN. Patient 1 demonstrated 4+ anti-D serologic testing beyond 2 months; therefore, antibody testing was performed on maternal breast milk. METHODS: Maternal serum samples were tested for the presence of unexpected antibodies using standard Ortho gel card and 37 °C 60 minutes with anti-human globulin (AHG) tube saline methods. Antibody titrations were performed using the standard 37 °C 60 minutes to AHG tube saline method. Fresh breast milk samples were tested using the standard 37 °C 60 minutes to AHG tube saline method for both unexpected antibodies and titration study. Fresh breast milk from an O-positive, antibody-negative donor was used as control for any reactivity that may have been due to milk solids or proteins alone. RESULTS: Using a known methodology applied in a novel way to test breast milk for RBC alloantibodies, antibodies against fetal RBCs were identified in the maternal breast milk of three patients. CONCLUSION: Maternal RBC alloantibodies are present in breast milk and may be clinically significant in patients with prolonged recovery from HDFN.

J Hosp Infect ; 102(4): 454-460, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-30171886


The burden of healthcare-associated infections (HCAIs) has traditionally been measured using clinical and economic outcomes. We conducted semi-structured interviews with 18 patients or their caregivers affected by HCAI caused by multidrug-resistant organisms to better understand the human impact of HCAI. Most patients had misconceptions about HCAI and antimicrobial resistance, leading to strong negative feelings towards HCAIs despite positive views of their healthcare providers. Communication issues across power imbalances need to be addressed to help deal with trauma of HCAIs. A holistic approach to HCAIs incorporating patient perspectives will likely help guide policymakers developing solutions to improve patient outcomes.

Infecções Bacterianas/economia , Infecções Bacterianas/psicologia , Infecção Hospitalar/economia , Infecção Hospitalar/psicologia , Resistência Microbiana a Medicamentos , Micoses/economia , Micoses/psicologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Comunicação em Saúde , Conhecimentos, Atitudes e Prática em Saúde , Humanos , Entrevistas como Assunto , Masculino , Pessoa de Meia-Idade
Rev. enferm. UERJ ; 26: e28921, jan.-dez. 2018.
Artigo em Português | LILACS, BDENF - Enfermagem | ID: biblio-1004056


Objetivos: identificar os conteúdos teórico-práticos relacionados à estomaterapia, no Curso de Graduação em Enfermagem, analisando seus conteúdos programáticos, estratégias e ementas; e discutir a abordagem dos conteúdos e das estratégias de ensino adotadas pelos docentes para o aprendizado de tais conteúdos. Método: estudo qualitativo, documental, cujo cenário foi a Faculdade de Enfermagem da Universidade do Estado do Rio de Janeiro. A pesquisa documental utilizou especificamente as ementas e os cronogramas do 1º ao 9° períodos da graduação. A coleta de dados ocorreu em novembro de 2016, sendo submetidos à análise de conteúdo modalidade temática. Resultados: evidenciou-se que os conteúdos abordados na graduação se referem às temáticas de feridas e estomias em sua predominância, e não se identificou conteúdo de incontinências. Conclusão:considera-se que há necessidade de inserir conteúdo relativo à incontinência anal e urinária haja vista a relevância epidemiológica e o sofrimento psicofísico da pessoa com tal problemática.

Objectives: to identify the theoretical and practical stomatherapy-related subjects in the undergraduate nursing program, analyzing their program content, strategies and outlines; and to discuss the approach to the content and the teaching strategies adopted by teachers for such content. Method: qualitative, documentary study, conducted at the nursing department of Rio de Janeiro State University. The documentary research used specifically the outlines and timetables from the 1st to 9th undergraduate terms. Data were collected in November 2016, and subjected to thematic content analysis. Results: the content addressed in the undergraduate course was found to refer predominantly to the themes of wounds and stomas, and no incontinence-related content was identified. Conclusion: there was considered to be a need to introduce content on anal and urinary incontinence, given the epidemiological relevance and psychophysical suffering of people with such problems.

Objetivos: identificar los contenidos teóricos y prácticos relativos a estomaterapia, en el curso de pregrado en enfermería, analizando sus contenidos programáticos, estrategias y registros; y discutir el enfoque de los contenidos y de las estrategias de enseñanza adoptadas por los profesores para el aprendizaje de dicho contenido. Método: estudio cualitativo, documental, cuyo escenario fue la Facultad de Enfermería de la Universidad del Estado de Río de Janeiro. La investigación documental utilizó específicamente los registros y los cronogramas del 1º al 9º períodos de pregrado. La recolección de datos se produjo en noviembre de 2016, siendo sometidos al análisis de contenido temático. Resultados: se evidenció que los contenidos abordados en el pregrado se refieren a temáticas de heridas y estomas en general y no se identificó contenido sobre incontinencias. Conclusión: se considera que existe una necesidad de insertar contenido relacionado a incontinencia anal y urinaria, dada la importancia epidemiológica y el sufrimiento psicofísico de la persona con dicho problema.

Ferimentos e Lesões , Estomia/educação , Estomia/enfermagem , Educação em Enfermagem , Pesquisa Qualitativa , Educação em Enfermagem/métodos
Rev. enferm. UERJ ; 26: e31170, jan.-dez. 2018. tab
Artigo em Português | LILACS-Express | ID: biblio-1004065


Objetivo: determinar as questões de saúde que levam os profissionais de enfermagem a licenciarem-se do trabalho por mais de 15 dias ou sofrerem readaptação funcional. Métodos: pesquisa documental, retrospectiva com abordagem quantitativa. Foram analisados 886 registros de afastamentos da equipe de enfermagem de um hospital universitário. Os dados foram apresentados por meio de estatística descritiva. Resultados: os afastamentos dos trabalhadores foram atribuídos, principalmente, transtornos mentais e comportamentais (22,6%), seguidos das doenças do sistema osteomuscular e do tecido conjuntivo (24,4%) dos casos. Em relação aos motivos que levaram os profissionais a sofrerem readaptação funcional, captou-se como principal causa as doenças osteomusculares (56,3%), registrando-se em seguida os transtornos mentais (18,8%). Conclusão: os trabalhadores possuem elevado índice de adoecimento por doenças osteomusculares, no entanto, preocupa o crescente adoecimento mental. Portanto, é necessário intensificar medidas protetoras para prevenção do adoecimento e melhoradas condições laborais.

Objective: to determine the health problems that lead nursing professionals to leave work for more than 15 days or to undergo functional readjustment. Methods: in this quantitative, retrospective, documentary study, 886 records of absence of the nursing staff at an university hospital were examined. Data were presented using descriptive statistics. Results: workers' absences were attributed mainly to mental and behavioral disorders (22.6%), followed by musculoskeletal system and connective tissue diseases (24.4%). The main causes that led nursing staff to undergo functional rehabilitation, were musculoskeletal diseases (56.3%), followed by mental disorders (18.8%). Conclusion:nursing workers display high rates of illness from musculoskeletal diseases; however, growing mental illness is worrisome. Therefore, it is necessary to intensify protective measures to prevent illness and improve working conditions.

Objetivo: determinar los problemas de salud que llevan a los profesionales de enfermería al alejamiento del trabajo por más de 15 días o a una readaptación funcional. Métodos: investigación documental, retrospectiva con enfoque cuantitativo. Se analizaron 886 registros de alejamientos del equipo de enfermería en un hospital universitario. Los datos se presentaron a través de estadística descriptiva. Resultados: los alejamientos de los trabajadores se atribuyeron principalmente a trastornos mentales y comportamentales (22,6%), y a las enfermedades del sistema músculo esquelético y del tejido conjuntivo (24,4%). Respecto a los motivos que llevaron a los profesionales a pasar por readaptación funcional, las principales causas fueron las enfermedades músculo esqueléticas (56,3%) y, después, trastornos mentales (18,8%). Conclusión: los trabajadores tienen una elevada tasa de enfermedades musculo esqueléticas, sin embargo, es preocupante el creciente número de enfermedades mentales. Por lo tanto, es necesario intensificar las medidas de protección para prevenir enfermedades y mejorar las condiciones de trabajo.

Rev. enferm. UERJ ; 26: e30716, jan.-dez. 2018.
Artigo em Português | LILACS, BDENF - Enfermagem | ID: biblio-991135


Objetivos: discutir e analisar os micropoderes existentes no cotidiano do trabalho de enfermagem hospitalar, de acordo com o pensamento de Foucault. Conteúdo: o ponto de partida é a análise histórica da divisão do trabalho, na área hospitalar e da enfermagem, em que se evidenciam características comuns aos conceitos de micropoderes discutidos por Foucault. Constata-se a existência de padrões de comportamento e disciplina na atuação da enfermagem hospitalar que são compatíveis com os pressupostos teóricos foucaultianos. Conclusão: é necessário aprofundamento das discussões sobre esta temática com intuito de ampliar o entendimento acerca da prática profissional da enfermagem hospitalar, bem como estabelecer mecanismos que possibilitem a análise pelos trabalhadores de seu cotidiano visando à transformação de posturas e comportamentos. São necessários mobilização e envolvimento coletivo para que processos de mudança aconteçam nas relações de poder que permeiam a profissão de enfermagem.

Objectives: to examine and discuss micro-powers in the daily work of hospital nursing, in the light of the thinking of Foucault. Content: the point of departure was a historical analysis of the division of labor at hospitals and in nursing, which evidenced features in common with the concepts of micro-powers discussed by Foucault. Patterns of behavior and discipline were found to exist in the practice of nursing that are compatible with Foucault's theoretical assumptions. Conclusion: this issue needs to be discussed in greater depth for a broader understanding of the professional practice of hospital nursing, as well as to establish mechanisms that enable workers to examine their daily activities with a view to modifying postures and behavior. Mobilization and collective involvement are also necessary for processes of change to take place in the power relations that permeate the nursing profession.

Objetivos: discutir y analizar los micropoderes existentes en el cotidiano del trabajo de enfermería hospitalaria, de acuerdo con el pensamiento de Foucault. Contenido: el punto de partida es el análisis histórico de la división del trabajo, en el área hospitalaria y de la enfermería, en que quedan evidentes las características comunes a los conceptos de micropoderes discutidos por Foucault. Se constata la existencia de patrones de comportamiento y disciplina en la actuación de la enfermería hospitalaria que son compatibles con los presupuestos teóricos foucaultianos. Conclusión: es necesario profundizar las discusiones sobre esta temática con el propósito de ampliar el entendimiento acerca de la práctica profesional de la enfermería hospitalaria, así como establecer mecanismos que posibiliten que los trabajadores hagan el análisis de su cotidiano con vistas a la transformación de posturas y comportamientos. Se apunta, además, la necesidad de movilización e implicación colectiva para que procesos de cambio ocurran en las relaciones de poder que impregnan la profesión de enfermería.

Humanos , Condições de Trabalho , Poder (Psicologia) , Capitalismo , Relações Interprofissionais , Serviço Hospitalar de Enfermagem , Teoria de Enfermagem , Brasil
Fa Yi Xue Za Zhi ; 34(5): 492-494, 2018 Oct.
Artigo em Inglês, Chinês | MEDLINE | ID: mdl-30468051


OBJECTIVES: To determine the electrical conductivity (EC) of the liver, spleen and kidney of rats at different postmortem intervals (PMIs) within 24 hours for investigating the relationship between EC of different organs and early PMI. METHODS: Totally 45 SD rats were sacrificed by cervical dislocation and kept at a constant temperature of 25 ℃. Tissues were taken from the liver, spleen, and kidney of rats at 0, 3, 6, 9, 12, 15, 18, 21 and 24 h. Impregnating solution with a mass concentration 0.1 g/mL was prepared using deionized water. The EC value of impregnating solution with different organs was separately determined. The regression equations of EC and PMI for different organs were established, respectively. The relationship between EC of different organs and early PMI was analysed in deceased rats. RESULTS: The relationship between PMI and EC of the liver and spleen was well fitted with the linear equation. The liver showed the best fitting degree followed by the spleen, while the EC of the kidney showed no significant changes within 24 h. There was a good linear relationship between early PMI and the EC of the liver and spleen. CONCLUSIONS: A good linear relationship between early PMI and the EC of the liver and spleen can be found in rats after death, which can be used for the early PMI estimation.

Condutividade Elétrica , Mudanças Depois da Morte , Baço , Animais , Patologia Legal , Fígado , Ratos , Ratos Sprague-Dawley , Fatores de Tempo
Eur Rev Med Pharmacol Sci ; 22(17): 5531-5538, 2018 09.
Artigo em Inglês | MEDLINE | ID: mdl-30229825


OBJECTIVE: To investigate the biological role of micro-ribonucleic acid (miR)-29a in non-small-cell lung cancer (NSCLC). PATIENTS AND METHODS: 55 cases of NSCLC tissue specimens and paired normal lung tissue specimens collected in the Department II of Oncology, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine from July 2012 to April 2015 were randomly included. The fluorescent quantitative polymerase chain reaction, Western blotting, and immunohistochemistry were performed to detect the expression levels of miR-29a and metastasis suppressor 1 (MTSS1). Pearson correlation analysis was utilized to investigate the relationship between miR-29a expression and MTSS1 expression in NSCLC tissues, and the Kaplan-Meier survival curves were constructed to analyze the association of miR-29a expression with the survival time of NSCLC patients. A54 proliferation and invasion abilities were measured by means of plate clone formation assay, and transwell assay after the miR-29a was suppressed by miRNA inhibitor. Luciferase assay was used to detect the target gene of miR-29a. RESULTS: In NSCLC tissues, the miR-29a expression level was higher than that in normal lung tissues (p<0.05), while the expression level of MTSS1 protein was remarkably lower than that in normal lung tissues (p<0.05). The median survival time of the patients was 15.1 months in high miR-29a expression group and 18.3 months in low miR-29a expression group (p<0.05). The miR-29a expression was negatively correlated with the expression level of MTSS1 protein in NSCLC tissues (r=-0.762, p<0.05). Luciferase results suggest that miR-29a binds to the promoter region of MTSS1 and inhibits its transcription level. The expression of MTSS1 protein was up-regulated notably after miR-29a knockdown by an inhibitor. It was revealed in the results of transwell assay and plate clone formation assay that the proliferative and invasive capacity of A549 cells was significantly decreased after knockdown of miR-29a. CONCLUSIONS: The transcribed miR-29a down-regulates the protein level of MTSS1, suppressor of tumor proliferation and invasion, thereby promoting the proliferative and invasive capacity of NSCLC cells. Both miR-29a and MTSS1 are expected to become potential therapeutic targets for NSCLC.

Carcinoma Pulmonar de Células não Pequenas/metabolismo , Proliferação de Células/fisiologia , Neoplasias Pulmonares/metabolismo , MicroRNAs/biossíntese , Proteínas dos Microfilamentos/biossíntese , Proteínas de Neoplasias/biossíntese , Células A549 , Adulto , Idoso , Carcinoma Pulmonar de Células não Pequenas/genética , Carcinoma Pulmonar de Células não Pequenas/patologia , Movimento Celular/fisiologia , Feminino , Humanos , Neoplasias Pulmonares/genética , Neoplasias Pulmonares/patologia , Masculino , MicroRNAs/genética , Proteínas dos Microfilamentos/antagonistas & inibidores , Proteínas dos Microfilamentos/genética , Pessoa de Meia-Idade , Invasividade Neoplásica/genética , Invasividade Neoplásica/patologia , Proteínas de Neoplasias/antagonistas & inibidores , Proteínas de Neoplasias/genética