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1.
PLoS One ; 14(5): e0217245, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31150440

RESUMO

BACKGROUND: Chlamydia trachomatis causes the most prevalent bacterial Sexual Transmitted Infection. In pregnant women, untreated chlamydial infections are associated with abortions, premature rupture of membranes, postpartum endometritis, low birth weight and transmission to the newborn. In Córdoba, Argentina, there is little knowledge about the prevalence of Chlamydia trachomatis in women in their third trimester of pregnancy, so, the aim of this study was to evaluate Chlamydia trachomatis prevalence and genotypes present in Cordovan pregnant women with different age and socioeconomic status. METHODS AND FINDINGS: Design: prospective study. Settings: Women population from Cordoba city, Argentina. Population: Pregnant women having 35 to 37 weeks of gestation. Methods: Five hundred and nine cervical swabs were collected. Each sample was subjected to DNA extraction and PCR for Chlamydia trachomatis using primers NRO/NLO and CTP1/CTP2. Positives samples were sequenced to determine genotype. Main outcome measures: Demographic data of the patients were collected to detect a population at risk for this infection. RESULTS: A prevalence of 6.9% (35/509) for Chlamydia trachomatis infection was detected, with 32/295 and 3/214 from pregnant women with low or better economic resources respectively (p = 0,0001). Results showed a significantly increased rate of 11.6% (30/258) in women under 25 years compared with 2% (5/251) in patients over that age (p = 0,00003). Genotype E was the most prevalent. CONCLUSIONS: With these results, we can say that pregnant women under 25 years old and low economic resources are one of the populations in which the screening programs of Chlamydia trachomatis should focus.


Assuntos
Infecções por Chlamydia/epidemiologia , Infecções por Chlamydia/microbiologia , Chlamydia trachomatis/genética , Complicações Infecciosas na Gravidez/epidemiologia , Complicações Infecciosas na Gravidez/microbiologia , Aborto Induzido/métodos , Adolescente , Adulto , Argentina , Chlamydia trachomatis/patogenicidade , Feminino , Genótipo , Humanos , Recém-Nascido de Baixo Peso , Recém-Nascido , Gravidez , Prevalência , Estudos Prospectivos , Fatores de Risco , Comportamento Sexual , Adulto Jovem
2.
Sci Rep ; 7(1): 5757, 2017 07 18.
Artigo em Inglês | MEDLINE | ID: mdl-28720756

RESUMO

Pixuna virus (PIXV) is an enzootic member of the Venezuelan Equine Encephalitis Virus complex and belongs to the New World cluster of alphaviruses. Herein we explore the role of the cellular cytoskeleton during PIXV replication. We first identified that PIXV undergoes an eclipse phase consisting of 4 h followed by 20 h of an exponential phase in Vero cells. The infected cells showed morphological changes due to structural modifications in actin microfilaments (MFs) and microtubules (MTs). Cytoskeleton-binding agents, that alter the architecture and dynamics of MFs and MTs, were used to study the role of cytoskeleton on PIXV replication. The virus production was significantly affected (p < 0.05) after treatment with paclitaxel or nocodazole due to changes in the MTs network. Interestingly, disassembly of MFs with cytochalasin D, at early stage of PIXV replication cycle, significantly increased the virus yields in the extracellular medium (p < 0.005). Furthermore, the stabilization of actin network with jasplakinolide had no effect on virus yields. Our results demonstrate that PIXV relies not only on intact MTs for the efficient production of virus, but also on a dynamic actin network during the early steps of viral replication.


Assuntos
Alphavirus/fisiologia , Citoesqueleto/virologia , Microtúbulos/virologia , Replicação Viral , Alphavirus/efeitos dos fármacos , Animais , Citocalasina D/farmacologia , Citoesqueleto/efeitos dos fármacos , Depsipeptídeos/farmacologia , Interações Hospedeiro-Patógeno , Microtúbulos/efeitos dos fármacos , Nocodazol/farmacologia , Paclitaxel/farmacologia , Fatores de Tempo , Moduladores de Tubulina/farmacologia , Células Vero
3.
Infect Genet Evol ; 44: 43-45, 2016 10.
Artigo em Inglês | MEDLINE | ID: mdl-27328126

RESUMO

In this study, genetic diversity of Chlamydia pneumoniae was investigated and the relationships between sequences amplified of different sources, clinical conditions and geographical regions of central Argentina were established. Samples amplified were similar to human C. pneumoniae patterns and show the high clonality of the population.


Assuntos
Chlamydophila pneumoniae/genética , Animais , Argentina , Proteínas da Membrana Bacteriana Externa/genética , Proteínas de Bactérias/genética , Infecções por Chlamydia/microbiologia , Chlamydophila pneumoniae/isolamento & purificação , Chlamydophila pneumoniae/patogenicidade , Humanos , Filogenia
4.
Asian Pac J Cancer Prev ; 17(5): 2689-94, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-27268652

RESUMO

BACKGROUND: Most studies of human papilloma virus (HPV) are aimed at the natural history of the infection and its relation to cancer; however, there are few studies to assess knowledge of the general population. Our aim was analyze the degree of knowledge of Argentinians about HPV infection and its prevention. MATERIALS AND METHODS: We conducted a voluntary, anonymous and non-binding survey with 27 multiple-choice items, in twelve private and public establishments, selected to include a broad population in terms of education, age and gender. The survey consisted of three sections: individual characteristics of the volunteer, HPV infection basic knowledge, its prevention and the virus relationship with other cancers. RESULTS: One thousand two hundred ninety seven volunteers aged 18 to 80 participated. The total number of correct answers was 45.1%. The correct answers for relationship HPV and cervical cancer was 62.1%. Almost 55% did not know about types of HPV that the vaccines for protection. Statistical analysis showed that women, single people, workers, the better educated, those who have had a STDs or HPV and receiving information through medical or educational establishments had greater knowledge of the topic. Only 0.2% of participants answered all questions correctly. CONCLUSIONS: Knowledge plays an important role in health care and the deficiency found in our population could influence the success of the measures taken in the fight against cervical cancer. In this regard, we believe it would be appropriate, not only to emphasize early diagnosis and vaccine implementation, but also incorporate new communication strategies, facilitating reception of accurate and precise information by all strata of society.


Assuntos
Conhecimentos, Atitudes e Prática em Saúde , Papillomaviridae/patogenicidade , Infecções por Papillomavirus/prevenção & controle , Vacinas contra Papillomavirus/uso terapêutico , Neoplasias do Colo do Útero/prevenção & controle , Adolescente , Adulto , Argentina , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Papillomaviridae/isolamento & purificação , Infecções por Papillomavirus/virologia , Aceitação pelo Paciente de Cuidados de Saúde , Prognóstico , Inquéritos e Questionários , Neoplasias do Colo do Útero/virologia , Vacinação , Adulto Jovem
5.
Asian Pac J Cancer Prev ; 16(3): 1151-7, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-25735347

RESUMO

Human papillomavirus (HPV) is responsible for one of the most frequent sexually transmitted infections. The first phylogenetic analysis was based on a LCR region fragment. Nowadays, 4 variants are known: African (Af-1, Af-2), Asian-American (AA) and European (E). However the existence of sub-lineages of the European variant havs been proposed, specific mutations in the E6 and LCR sequences being possibly related to persistent viral infections. The aim of this study was a phylogenetic study of HPV16 sequences of endocervical samples from Cordoba, in order to detect the circulating lineages and analyze the presence of mutations that could be correlated with malignant disease. The phylogenetic analysis determined that 86% of the samples belonged to the E variant, 7% to AF-1 and the remaining 7% to AF-2. The most frequent mutation in LCR sequences was G7521A, in 80% of the analyzed samples; it affects the binding site of a transcription factor that could contribute to carcinogenesis. In the E6 sequences, the most common mutation was T350G (L83V), detected in 67% of the samples, associated with increased risk of persistent infection. The high detection rate of the European lineage correlated with patterns of human migration. This study emphasizes the importance of recognizing circulating lineages, as well as the detection of mutations associated with high-grade neoplastic lesions that could be correlated to the development of carcinogenic lesions.


Assuntos
Carcinoma de Células Escamosas/genética , Papillomavirus Humano 16/genética , Região de Controle de Locus Gênico/genética , Mutação/genética , Proteínas Oncogênicas Virais/genética , Infecções por Papillomavirus/genética , Proteínas Repressoras/genética , Neoplasias do Colo do Útero/genética , Carcinogênese , Carcinoma de Células Escamosas/diagnóstico , Carcinoma de Células Escamosas/virologia , DNA Viral/genética , Feminino , Seguimentos , Humanos , Gradação de Tumores , Infecções por Papillomavirus/diagnóstico , Infecções por Papillomavirus/virologia , Filogenia , Reação em Cadeia da Polimerase , Polimorfismo Genético/genética , Prognóstico , Neoplasias do Colo do Útero/diagnóstico , Neoplasias do Colo do Útero/virologia
6.
Avian Pathol ; 44(1): 50-6, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-25469538

RESUMO

To study the occurrence of Chlamydia spp. and their genetic diversity, we analysed 793 cloacal swabs from 12 avian orders, including 76 genera, obtained from 80 species of asymptomatic wild and captive birds that were examined with conventional nested polymerase chain reaction and quantitative polymerase chain reaction. Chlamydia spp. were not detected in wild birds; however, four species (Chlamydia psittaci, Chlamydia pecorum, Chlamydia pneumoniae and Chlamydia gallinacea) were identified among captive birds (Passeriformes, n = 20; Psittaciformes, n = 15; Rheiformes, n = 8; Falconiformes n = 2; Piciformes n = 2; Anseriformes n = 1; Galliformes n = 1; Strigiformes n = 1). Two pathogens (C. pneumoniae and C. pecorum) were identified simultaneously in samples obtained from captive birds. Based on nucleotide-sequence variations of the ompA gene, three C. psittaci-positive samples detected were grouped into a cluster with the genotype WC derived from mammalian hosts. A single positive sample was phylogenetically related to a new strain of C. gallinacea. This report contributes to our increasing understanding of the abundance of Chlamydia in the animal kingdom.


Assuntos
Aves/microbiologia , Chlamydia/genética , Variação Genética , Animais , Argentina , Proteínas da Membrana Bacteriana Externa/genética , Sequência de Bases , Chlamydia/classificação , Análise por Conglomerados , Primers do DNA/genética , Dados de Sequência Molecular , Filogenia , Reação em Cadeia da Polimerase/veterinária , RNA Ribossômico 23S/genética , Reação em Cadeia da Polimerase em Tempo Real/veterinária , Análise de Sequência de DNA/veterinária , Especificidade da Espécie
7.
Rev Argent Microbiol ; 46(1): 45-8, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-24721274

RESUMO

In the central area of Argentina, the epidemiological and molecular characteristics of Chlamydophila pneumoniae infections in reptiles are still unknown. A nested polymerase chain reaction of the rpoB gene was used to detect C. pneumoniae in cloacal swab samples from 19 reptiles at a recreational area. Eleven (57.89%) reptiles were positive; the sequencing and phylogenetic analysis confirmed the presence of this bacterium. Neither C. pneumoniae DNA in the caregivers pharynges nor IgM antibodies anti-C. pneumoniae in their serum samples were detected; however, caregivers presented very high titers of IgG anti-C. pneumoniae. The detection of C. pneumoniae DNA in reptiles demonstrated the circulation of this agent in the recreational area and could be responsible for the exacerbated immune response of the personnel handling the reptiles, which suggests a potential zoonotic cycle. This is the first report of the detection of C. pneumoniae in reptiles in Argentina.


Assuntos
Infecções por Chlamydophila/veterinária , Chlamydophila pneumoniae/isolamento & purificação , Reservatórios de Doenças/microbiologia , Répteis/microbiologia , Criação de Animais Domésticos , Animais , Anticorpos Antibacterianos/sangue , Argentina/epidemiologia , Boidae/microbiologia , Bothrops/microbiologia , Infecções por Chlamydophila/epidemiologia , Infecções por Chlamydophila/microbiologia , Chlamydophila pneumoniae/genética , Chlamydophila pneumoniae/imunologia , Cloaca/microbiologia , DNA Bacteriano/análise , DNA Bacteriano/genética , Elapidae/microbiologia , Humanos , Dados de Sequência Molecular , Exposição Ocupacional , Faringe/microbiologia , Filogenia , Reação em Cadeia da Polimerase , Análise de Sequência de DNA , Tartarugas/microbiologia , Zoonoses
8.
Rev. argent. microbiol ; 46(1): 45-48, mar. 2014.
Artigo em Inglês | LILACS | ID: biblio-1009788

RESUMO

En la región central de Argentina, las características epidemiológicas y moleculares de las infecciones por Chlamydophila pneumoniae en reptiles son desconocidas. Para detectar C. pneumoniae, se usó la reacción en cadena de la polimerasa anidada que amplifica el gen rpoB en muestras de hisopado cloacal de 19 reptiles. Once (57,89 %) reptiles resultaron positivos. La secuenciación y el análisis filogenético corroboraron la presencia de esta bacteria. No se detectó ADN de C. pneumoniae en la faringe ni IgM anti-C. pneumoniae en el suero de los cuidadores; sin embargo, ellos presentaron títulos muy elevados de IgG anti-C. pneumoniae. La detección de ADN de C. pneumoniae en los reptiles demostró la circulación de este agente en el centro recreativo donde se realizó este estudio, lo que podría explicar la exacerbada respuesta inmunitaria en los cuidadores; este hallazgo sugiere la presencia de un potencial ciclo zoonótico. Se reporta aquí por primera vez la detección de C. pneumoniae en reptiles en Argentina


In the central area of Argentina, the epidemiological and molecular characteristics of Chlamydophila pneumoniae infections in reptiles are still unknown. A nested polymerase chain reaction of the rpoB gene was used to detect C. pneumoniae in cloacal swab samples from 19 reptiles at a recreational area. Eleven (57.89%) reptiles were positive; the sequencing and phylogenetic analysis confirmed the presence of this bacterium. Neither C. pneumoniae DNA in the caregivers'pharynges nor IgM antibodies anti-C. pneumoniae in their serum samples were detected; however, caregivers presented very high titers of IgG anti-C. pneumoniae. The detection of C. pneumoniae DNA in reptiles demonstrated the circulation of this agent in the recreational area and could be responsible for the exacerbated immune response of the personnel handling the reptiles, which suggests a potential zoonotic cycle. This is the first report of the detection of C. pneumoniae in reptiles in Argentina


Assuntos
Animais , Argentina/epidemiologia , Répteis/microbiologia , Infecções por Chlamydophila/diagnóstico , Filogenia , Análise Bacteriológica/métodos , Chlamydophila pneumoniae/isolamento & purificação
9.
Rev. argent. microbiol ; 46(1): 45-8, 2014 Jan-Mar.
Artigo em Espanhol | BINACIS | ID: bin-133713

RESUMO

In the central area of Argentina, the epidemiological and molecular characteristics of Chlamydophila pneumoniae infections in reptiles are still unknown. A nested polymerase chain reaction of the rpoB gene was used to detect C. pneumoniae in cloacal swab samples from 19 reptiles at a recreational area. Eleven (57.89


) reptiles were positive; the sequencing and phylogenetic analysis confirmed the presence of this bacterium. Neither C. pneumoniae DNA in the caregivers pharynges nor IgM antibodies anti-C. pneumoniae in their serum samples were detected; however, caregivers presented very high titers of IgG anti-C. pneumoniae. The detection of C. pneumoniae DNA in reptiles demonstrated the circulation of this agent in the recreational area and could be responsible for the exacerbated immune response of the personnel handling the reptiles, which suggests a potential zoonotic cycle. This is the first report of the detection of C. pneumoniae in reptiles in Argentina.


Assuntos
Infecções por Chlamydophila/veterinária , Chlamydophila pneumoniae/isolamento & purificação , Reservatórios de Doenças/microbiologia , Répteis/microbiologia , Criação de Animais Domésticos , Animais , Anticorpos Antibacterianos/sangue , Argentina/epidemiologia , Boidae/microbiologia , Bothrops/microbiologia , Infecções por Chlamydophila/epidemiologia , Infecções por Chlamydophila/microbiologia , Chlamydophila pneumoniae/genética , Chlamydophila pneumoniae/imunologia , Cloaca/microbiologia , DNA Bacteriano/análise , DNA Bacteriano/genética , Elapidae/microbiologia , Humanos , Dados de Sequência Molecular , Exposição Ocupacional , Faringe/microbiologia , Filogenia , Reação em Cadeia da Polimerase , Análise de Sequência de DNA , Tartarugas/microbiologia , Zoonoses
10.
Acta Odontol Latinoam ; 25(1): 82-8, 2012.
Artigo em Inglês | MEDLINE | ID: mdl-22928386

RESUMO

The purpose of this study was to investigate the relationship between P gingivalis, T forsythia, T denticola, P intermedia, and A. actinomycetemcomitans in the sulci or pockets of patients with gingivitis (G), mild chronic periodontitis (MiCP), moderate chronic periodontitis (MoCP) and severe periodontitis (SP), and the expression of TNF-alpha in gingival tissue associated with clinical parameters. Six patients with G, 7 with MiCP, 23 with MoCP and 7 with SP were recruited. Pathogens obtained from the sulci or pockets were identified by PCR, and expression of TNF-alpha from gingival tissue was analysed Probing depth (PD), clinical attachment level (CAL) and loss of bone were recorded. P gingivalis was detected at the following rates: 16.6% in subjects with G 57.1% in MiCP 57.8 % in MoCP and 58.1% in SP (p < 0.05). P intermedia was not identified in subjects with G A. actinomycetemcomitans was only identified in subjects with MoCP (31.5%) and SP (42.8%). T denticola and T forsythia were identified in all subject groups. Bacterial combinations were identified as follows: P denticola + P intermedia and PR intermedia + T forsythia were associated (p = 0.04, p = 0.02) with the presence of TNF-alpha mRNA in 20% and 25% of subjects, respectively. P gingivalis + A. Actinomycetemcomitans andA. actinomycetemcomitans + T forsythia were associated with severe PD and CAL, respectively. The association between the presence of P intermedia and expression levels of TNF-alpha was significant (p = 0.05). These results indicate that the proportion of patients with P gingivalis increases with the progression of disease. We observed that the presence of P intermedia may trigger the expression of TNF-alpha and cause a worsening of the patient's clinical status.


Assuntos
Doenças Periodontais/metabolismo , Doenças Periodontais/microbiologia , Fator de Necrose Tumoral alfa/biossíntese , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Periodontite/metabolismo , Periodontite/microbiologia
11.
Diagn Microbiol Infect Dis ; 74(3): 320-2, 2012 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-22917583

RESUMO

In central area of Argentina, the epidemiologic and molecular characteristics of Chlamydophila psittaci infections are still unknown. Nested polymerase chain reaction of domains II, III, and IV of the omp A gene was used to detect Chlamydophila in 43 pharyngeal swab samples from patients with suspected human psittacosis (2010-2011); 9 (21%) of them yielded positive results. Molecular typing was performed by direct sequencing demonstrating the presence of C. psittaci genotypes A, E/B, and WC.


Assuntos
Chlamydophila psittaci/classificação , Chlamydophila psittaci/genética , DNA Bacteriano/genética , Psitacose/microbiologia , Adolescente , Adulto , Idoso , Animais , Argentina/epidemiologia , Criança , Chlamydophila psittaci/isolamento & purificação , DNA Bacteriano/química , Feminino , Genótipo , Humanos , Masculino , Pessoa de Meia-Idade , Epidemiologia Molecular , Dados de Sequência Molecular , Tipagem Molecular , Nasofaringe/microbiologia , Reação em Cadeia da Polimerase , Psitacose/epidemiologia , Análise de Sequência de DNA , Adulto Jovem
12.
Acta odontol. latinoam ; 25(1): 82-88, 2012. tab
Artigo em Inglês | LILACS | ID: lil-679770

RESUMO

El propósito de este trabajo fue fue investigar la relación entreP. gingivalis, T. forsythia, T. denticola, P.intermedia, y A. actinomycetemcomitanspresentes en surcos y/o bolsas de pacientes con gingivitis (G), periodontitis crónica leve (MiCP), periodontitis crónica moderada (MoCP) y periodontitis severa (PS) y la expresi¨®n de TNF-¦Á en tejido gingival segun el estado clínico periodontal. Para ello se seleccionaron seis pacientes con G, 7 con MiCP, 23 con MoCP y 7 con PS. Los patogenos extraidos de los surcos y/o bolsas se identificaron mediante PCR con cebadores especificos para cada especie, Se detectó la expresión de TNF-¦Á en tejido gingival. Se registraron los siguientes parametros clinicos: profundidad al sondaje (PD), perdida de inserción clónica (CAL) y perdida de hueso. Se detectó P. gingivalis con la siguiente frecuencia: 16,6 por ciento en sujetos con G, 57,1 por ciento en MiCP, 57.8 por ciento en MoCP y 58.1 por ciento en PS (p < 0,05). P. intermedia no fue detectada en pacientes con G y A. actinomycetemcomitans fue solamenteidentificado en MoCP (31,5 por ciento) y PS (42.8 por ciento) T denticola y T. forsythia se identificaron en todos los grupos. Las combinaciones bacterianas P. denticola + P. intermedia y P. intermedia + T. forsythia se identificaron asociadas significativamente (p = 0,04, p =0,02) con la presencia de mRNA TNF-¦Á en 20 por ciento y 25 por ciento de los sujetos, respectivamente. P. gingivalis + A. actinomycetemcomitans y A. actinomycetemcomitans + T. forsythia se asociaron con valores de PD y CAL de gravedad. La asociación entre la presencia de P. intermedia y los niveles de expresi¨®n de TNF-¦Á fue significativa(p = 0,05). Estos resultados indican que la proporción de pacientes con P. gingivalis aumenta con la progresión de la enfermedad. Observamos que la presencia de P.intermedia desencadenaria la expresión de TNF-¦Á y provocaria un empeoramiento del estado clinico del paciente.


Assuntos
Humanos , Masculino , Adulto , Feminino , Pessoa de Meia-Idade , Doenças Periodontais/metabolismo , Doenças Periodontais/microbiologia , Fator de Necrose Tumoral alfa , Periodontite/metabolismo , Periodontite/microbiologia
13.
Acta odontol. latinoam ; 25(1): 82-88, 2012. tab
Artigo em Inglês | BINACIS | ID: bin-128710

RESUMO

El propósito de este trabajo fue fue investigar la relación entreP. gingivalis, T. forsythia, T. denticola, P.intermedia, y A. actinomycetemcomitanspresentes en surcos y/o bolsas de pacientes con gingivitis (G), periodontitis crónica leve (MiCP), periodontitis crónica moderada (MoCP) y periodontitis severa (PS) y la expresi¿«n de TNF-ªA en tejido gingival segun el estado clínico periodontal. Para ello se seleccionaron seis pacientes con G, 7 con MiCP, 23 con MoCP y 7 con PS. Los patogenos extraidos de los surcos y/o bolsas se identificaron mediante PCR con cebadores especificos para cada especie, Se detectó la expresión de TNF-ªA en tejido gingival. Se registraron los siguientes parametros clinicos: profundidad al sondaje (PD), perdida de inserción clónica (CAL) y perdida de hueso. Se detectó P. gingivalis con la siguiente frecuencia: 16,6 por ciento en sujetos con G, 57,1 por ciento en MiCP, 57.8 por ciento en MoCP y 58.1 por ciento en PS (p < 0,05). P. intermedia no fue detectada en pacientes con G y A. actinomycetemcomitans fue solamenteidentificado en MoCP (31,5 por ciento) y PS (42.8 por ciento) T denticola y T. forsythia se identificaron en todos los grupos. Las combinaciones bacterianas P. denticola + P. intermedia y P. intermedia + T. forsythia se identificaron asociadas significativamente (p = 0,04, p =0,02) con la presencia de mRNA TNF-ªA en 20 por ciento y 25 por ciento de los sujetos, respectivamente. P. gingivalis + A. actinomycetemcomitans y A. actinomycetemcomitans + T. forsythia se asociaron con valores de PD y CAL de gravedad. La asociación entre la presencia de P. intermedia y los niveles de expresi¿«n de TNF-ªA fue significativa(p = 0,05). Estos resultados indican que la proporción de pacientes con P. gingivalis aumenta con la progresión de la enfermedad. Observamos que la presencia de P.intermedia desencadenaria la expresión de TNF-ªA y provocaria un empeoramiento del estado clinico del paciente.(AU)


Assuntos
Humanos , Masculino , Adulto , Feminino , Pessoa de Meia-Idade , Doenças Periodontais/metabolismo , Doenças Periodontais/microbiologia , Fator de Necrose Tumoral alfa , Periodontite/metabolismo , Periodontite/microbiologia
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