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1.
Trials ; 22(1): 595, 2021 Sep 06.
Artigo em Inglês | MEDLINE | ID: mdl-34488845

RESUMO

BACKGROUND: Chronic lower limb ischemia develops earlier and more frequently in patients with type 2 diabetes mellitus. Diabetes remains the main cause of lower-extremity non-traumatic amputations. Current medical treatment, based on antiplatelet therapy and statins, has demonstrated deficient improvement of the disease. In recent years, research has shown that it is possible to improve tissue perfusion through therapeutic angiogenesis. Both in animal models and humans, it has been shown that cell therapy can induce therapeutic angiogenesis, making mesenchymal stromal cell-based therapy one of the most promising therapeutic alternatives. The aim of this study is to evaluate the feasibility, safety, and efficacy of cell therapy based on mesenchymal stromal cells derived from adipose tissue intramuscular administration to patients with type 2 diabetes mellitus with critical limb ischemia and without possibility of revascularization. METHODS: A multicenter, randomized double-blind, placebo-controlled trial has been designed. Ninety eligible patients will be randomly assigned at a ratio 1:1:1 to one of the following: control group (n = 30), low-cell dose treatment group (n = 30), and high-cell dose treatment group (n = 30). Treatment will be administered in a single-dose way and patients will be followed for 12 months. Primary outcome (safety) will be evaluated by measuring the rate of adverse events within the study period. Secondary outcomes (efficacy) will be measured by assessing clinical, analytical, and imaging-test parameters. Tertiary outcome (quality of life) will be evaluated with SF-12 and VascuQol-6 scales. DISCUSSION: Chronic lower limb ischemia has limited therapeutic options and constitutes a public health problem in both developed and underdeveloped countries. Given that the current treatment is not established in daily clinical practice, it is essential to provide evidence-based data that allow taking a step forward in its clinical development. Also, the multidisciplinary coordination exercise needed to develop this clinical trial protocol will undoubtfully be useful to conduct academic clinical trials in the field of cell therapy in the near future. TRIAL REGISTRATION: ClinicalTrials.gov NCT04466007 . Registered on January 07, 2020. All items from the World Health Organization Trial Registration Data Set are included within the body of the protocol.


Assuntos
COVID-19 , Diabetes Mellitus Tipo 2 , Transplante de Células-Tronco Hematopoéticas , Células-Tronco Mesenquimais , Noma , Tecido Adiposo , Animais , Ensaios Clínicos Fase II como Assunto , Diabetes Mellitus Tipo 2/complicações , Diabetes Mellitus Tipo 2/diagnóstico , Diabetes Mellitus Tipo 2/terapia , Método Duplo-Cego , Humanos , Isquemia/diagnóstico , Isquemia/terapia , Estudos Multicêntricos como Assunto , Qualidade de Vida , Ensaios Clínicos Controlados Aleatórios como Assunto , SARS-CoV-2 , Resultado do Tratamento
2.
Sensors (Basel) ; 21(1)2020 Dec 27.
Artigo em Inglês | MEDLINE | ID: mdl-33375441

RESUMO

Brain-computer interfaces (BCI) can extract information about the subject's intentions by registering and processing electroencephalographic (EEG) signals to generate actions on physical systems. Steady-state visual-evoked potentials (SSVEP) are produced when the subject stares at flashing visual stimuli. By means of spectral analysis and by measuring the signal-to-noise ratio (SNR) of its harmonic contents, the observed stimulus can be identified. Stimulus color matters, and some authors have proposed red because of its ability to capture attention, while others refuse it because it might induce epileptic seizures. Green has also been proposed and it is claimed that white may generate the best signals. Regarding frequency, middle frequencies are claimed to produce the best SNR, although high frequencies have not been thoroughly studied, and might be advantageous due to the lower spontaneous cerebral activity in this frequency band. Here, we show white, red, and green stimuli, at three frequencies: 5 (low), 12 (middle), and 30 (high) Hz to 42 subjects, and compare them in order to find which one can produce the best SNR. We aim to know if the response to white is as strong as the one to red, and also if the response to high frequency is as strong as the one triggered by lower frequencies. Attention has been measured with the Conner's Continuous Performance Task version 2 (CPT-II) task, in order to search for a potential relationship between attentional capacity and the SNR previously obtained. An analysis of variance (ANOVA) shows the best SNR with the middle frequency, followed by the low, and finally the high one. White gives as good an SNR as red at 12 Hz and so does green at 5 Hz, with no differences at 30 Hz. These results suggest that middle frequencies are preferable and that using the red color can be avoided. Correlation analysis also show a correlation between attention and the SNR at low frequency, so suggesting that for the low frequencies, more attentional capacity leads to better results.

3.
Artigo em Inglês | MEDLINE | ID: mdl-33207680

RESUMO

Seaports' energy strategy should rely on the use of renewable energy. Presently, the share of renewable energy used by many of the ports worldwide is negligible. Some initiatives are in the process of implementation to produce some of the energy used by the Port of Valencia, one the largest ports in the Mediterranean Basin. Among these initiatives, a photovoltaic plant with an installed capacity of 5.5 MW is under a tendering process and the assessment studies for the deployment of three to five windmills are close to being finished. However, this is not enough to make it a "zero emissions port" as some of the energy demand would still be covered by fossil fuels. Therefore, we should consider clean alternative energy sources. This article analyses the wave energy resources in the surroundings of the Port of Valencia using a 7-year series of data obtained from numerical modelling (forecast). The spatial distribution of wave power is analysed using data from 3 SIMAR points at Valencia Bay and is compared to the data obtained by the Valencia Buoy I (removed in 2005). The obtained results are used to estimate the power matrices and the average energy output of two wave energy converters suitable to be integrated into the port's infrastructure. Finally, the wave energy converters' production is compared to the average amount of energy that is forecast to be obtained from other renewable sources such as solar and wind. Due to the nature of the Gulf's wave climate (mostly low waves), the main conclusion is that the energy obtainable from the waves in the Valencia Gulf will be in correlation with such climate. However, when dealing with great energy consumers every source of production is worthwhile and further research is needed to optimize the production of energy from renewable sources and its use in an industrial environment such as ports.


Assuntos
Fontes Geradoras de Energia , Energia Renovável , Ondas de Maré , Eletricidade , Fontes Geradoras de Energia/normas , Oceanos e Mares
4.
Sensors (Basel) ; 19(20)2019 Oct 16.
Artigo em Inglês | MEDLINE | ID: mdl-31623093

RESUMO

In this paper, an application for the management, supervision and failure forecast of a ship's energy storage system is developed through a National Marine Electronics Association (NMEA) 2000 smart sensor network. Here, the NMEA 2000 network sensor devices for the measurement and supervision of the parameters inherent to energy storage and energy supply are reviewed. The importance of energy storage systems in ships, the causes and models of battery aging, types of failures, and predictive diagnosis techniques for valve-regulated lead-acid (VRLA) batteries used for assisted and safe navigation are discussed. In ships, battery banks are installed in chambers that normally do not have temperature regulation and therefore are significantly conditioned by the outside temperature. A specific method based on the analysis of the time-series data of random and seasonal factors is proposed for the comparative trend analyses of both the battery internal temperature and the battery installation chamber temperature. The objective is to apply predictive fault diagnosis to detect any undesirable increase in battery temperature using prior indicators of heat dissipation process failure-to avoid the development of the most frequent and dangerous failure modes of VRLA batteries such as dry out and thermal runaway. It is concluded that these failure modes can be conveniently diagnosed by easily recognized patterns, obtained by performing comparative trend analyses to the variables measured onboard by NMEA sensors.

5.
Sensors (Basel) ; 18(4)2018 Mar 22.
Artigo em Inglês | MEDLINE | ID: mdl-29565823

RESUMO

In this paper we present a multi-sensor floating system designed to monitor marine energy parameters, in order to sample wind, wave, and marine current energy resources. For this purpose, a set of dedicated sensors to measure the height and period of the waves, wind, and marine current intensity and direction have been selected and installed in the system. The floating device incorporates wind and marine current turbines for renewable energy self-consumption and to carry out complementary studies on the stability of such a system. The feasibility, safety, sensor communications, and buoy stability of the floating device have been successfully checked in real operating conditions.

6.
ScientificWorldJournal ; 2014: 176463, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-25610897

RESUMO

This work proposes a new method for fault diagnosis in electric power systems based on neural modules. With this method the diagnosis is performed by assigning a neural module for each type of component comprising the electric power system, whether it is a transmission line, bus or transformer. The neural modules for buses and transformers comprise two diagnostic levels which take into consideration the logic states of switches and relays, both internal and back-up, with the exception of the neural module for transmission lines which also has a third diagnostic level which takes into account the oscillograms of fault voltages and currents as well as the frequency spectrums of these oscillograms, in order to verify if the transmission line had in fact been subjected to a fault. One important advantage of the diagnostic system proposed is that its implementation does not require the use of a network configurator for the system; it does not depend on the size of the power network nor does it require retraining of the neural modules if the power network increases in size, making its application possible to only one component, a specific area, or the whole context of the power system.


Assuntos
Fontes de Energia Elétrica , Eletricidade , Redes Neurais de Computação , Algoritmos , Simulação por Computador , Humanos
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